4-PBA (Sodium Phenylbutyrate)

別名:4-Phenylbutyric acid, NaPB

4-PBA (Sodium Phenylbutyrate) is a salt of 4-phenylbutyrate (4-PBA) or 4-phenylbutyric acid.Sodium phenylbutyrate is a histone deacetylase inhibitor, used to treat urea cycle disorders.

4-PBA (Sodium Phenylbutyrate)化学構造

CAS No. 1716-12-7

サイズ 価格(税別) 在庫状況
10mM (1mL in DMSO) JPY 23500 国内在庫あり
JPY 13300 国内在庫あり
JPY 80000 国内在庫なし(納期7~10日)

代表番号: 045-509-1970|電子メール:[email protected]
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文献中Selleckの製品使用例(18)

カスタマーフィードバック1个实验数据

製品安全説明書

現在のバッチを見る: 純度: 99.99%
99.99

4-PBA (Sodium Phenylbutyrate)関連製品

シグナル伝達経路

HDAC阻害剤の選択性比較

Cell Data

Cell Lines Assay Type Concentration Incubation Time 活性情報 PMID
HT-29 Function assay 4 mM 8 to 48 hrs Induction of CAMP mRNA expression in human HT-29 cells at 4 mM after 8 to 48 hrs by RT-PCR analysis 19770273
VA10 Function assay 4 mM 24 hrs Induction of CAMP mRNA expression in human VA10 cells at 4 mM after 24 hrs by RT-PCR analysis 19770273
U937 Function assay 4 mM 8 to 48 hrs Induction of CAMP mRNA expression in human U937 cells at 4 mM after 8 to 48 hrs by RT-PCR analysis 19770273
A498 Function assay 4 mM 8 to 48 hrs Induction of CAMP mRNA expression in human A498 cells at 4 mM after 8 to 48 hrs by RT-PCR analysis 19770273
VA10 Function assay 4 mM 24 hrs Induction of DEFB1 mRNA expression in human VA10 cells at 4 mM after 24 hrs by RT-PCR analysis 19770273
VA10 Function assay 4 mM 24 hrs Induction of LL-37 protein expression in human VA10 cells at 4 mM after 24 hrs by Western blotting 19770273
VA10 Function assay 20 nM 24 hrs Induction of LL-37 protein expression in human VA10 cells at 20 nM after 24 hrs by Western blotting 19770273
Hela Function assay Inhibition of HDAC in human Hela cells nuclear extracts by fluorimetric assay, Ki=6.34μM 19520580
他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

生物活性

製品説明 4-PBA (Sodium Phenylbutyrate) is a salt of 4-phenylbutyrate (4-PBA) or 4-phenylbutyric acid.Sodium phenylbutyrate is a histone deacetylase inhibitor, used to treat urea cycle disorders.
Targets
HDAC [1]
In Vitro
In vitro

Phenylbutyrate is a well-known HDAC inhibitor, which increases gene transcription of a number of genes, and also exerts neuroprotective effects. Phenylbutyrate significantly attenuates MPTP-induced depletion of striatal dopamine and loss of tyrosine hydroxylase-positive neurons in the substantia nigra. [1]

Phenylbutyrate attenuates the expression of the apoptosis antagonist Bcl-X(L), the double-strand break repair protein DNA-dependent protein kinase, the prostate progression marker caveolin-1, and the pro-angiogenic vascular endothelial growth factor in prostate cancer cells. Phenylbutyrate is found to act in synergy with ionizing radiation to induce apoptosis in prostate cancer cells. [2]

細胞実験 細胞株 HK-2 cells
濃度 1 mM
反応時間 24 h
実験の流れ

Cells were treated with indicated concentration of drug for 24 h.

実験結果図 Methods Biomarkers 結果図 PMID
Western blot Survivin p38 / p-p38 / ERK / p-ERK / JNK / p-JNK 27274278
In Vivo
In Vivo

Phenylbutyrate significantly extends survival and improved both the clinical and neuropathological phenotypes in G93A transgenic ALS mice. Phenylbutyrate administration ameliorates histone hypoacetylation observed in G93A mice and induced expression of nuclear factor-kappaB (NF-kappaB) p50, the phosphorylated inhibitory subunit of NF-kappaB (pIkappaB) and beta cell lymphoma 2 (bcl-2), but reduced cytochrome c and caspase expression. Phenylbutyrate acts to phosphorylate IkappaB, translocating NF-kappaB p50 to the nucleus, or to directly acetylate NF-kappaB p50. [3]

Phenylbutyrate increases brain histone acetylation and decreased histone methylation levels as assessed by both immunocytochemistry and Western blots in a transgenic mousemodel of Huntington's disease (HD). Phenylbutyrate increases mRNA for components of the ubiquitin-proteosomal pathway and down-regulated caspases implicated in apoptotic cell death, and active caspase 3 immunoreactivity in the striatum. [4]

動物実験 動物モデル Male C57BL/6 mice
投与量 120 mg/kg
投与経路 i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05983588 Recruiting
Corticobasal Syndrome (CBS)
Technical University of Munich
December 12 2023 Phase 2
NCT05019417 Unknown status
Monocarboxylate Transporter 8 Deficiency
Kaplan Medical Center|Weizmann Institute of Science
June 30 2021 Phase 2|Phase 3
NCT04937062 Enrolling by invitation
STXBP1 Encephalopathy With Epilepsy SLC6A1 Neurodevelopmental Disorder|Developmental and Epileptic Encephalopathy
Weill Medical College of Cornell University|Children''s Hospital Colorado|SLC6A1 Connect|STXBP1 Foundation|Clara Inspired|University of Pennsylvania Orphan Disease Center|Horizon Therapeutics
March 1 2021 Early Phase 1
NCT04421677 Completed
Inclusion Body Myositis|Sporadic Inclusion Body Myositis
University of Kansas Medical Center
August 20 2020 Phase 1
NCT02246218 Completed
Urea Cycle Disorder
Horizon Therapeutics LLC|Horizon Pharma Ireland Ltd. Dublin Ireland
December 31 2014 Phase 4
NCT01096095 Withdrawn
Spinocerebellar Ataxia Type 3
Hospital de Clinicas de Porto Alegre|Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul Brazil
June 2010 Phase 2

化学情報

分子量 187.19 化学式

C10H11O2.Na

CAS No. 1716-12-7 SDF Download 4-PBA (Sodium Phenylbutyrate) SDFをダウンロードする
Smiles C1=CC=C(C=C1)CCCC(=O)[O-].[Na+]
保管

In vitro
Batch:

DMSO : 37 mg/mL ( (197.66 mM); 吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。)

Water : 37 mg/mL

Ethanol : Insoluble

モル濃度計算器

in vivo
Batch:

Add solvents to the product individually and in order.

投与溶液組成計算機

実験計算

モル濃度計算器

質量 濃度 体積 分子量

投与溶液組成計算機(クリア溶液)

ステップ1:実験データを入力してください。(実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します)

mg/kg g μL

ステップ2:投与溶媒の組成を入力してください。(ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください)

% DMSO % % Tween 80 % ddH2O
%DMSO %

計算結果:

投与溶媒濃度: mg/ml;

DMSOストック溶液調製方法: mg 試薬を μL DMSOに溶解する(濃度 mg/mL, 注:濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。 )

投与溶媒調製方法:Take μL DMSOストック溶液に μL PEG300,を加え、完全溶解後μL Tween 80,を加えて完全溶解させた後 μL ddH2O,を加え完全に溶解させます。

投与溶媒調製方法:μL DMSOストック溶液に μL Corn oil,を加え、完全溶解。

注意:1.ストック溶液に沈殿、混濁などがないことをご確認ください;
2.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。

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