Stattic

Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1. Stattic induces apoptosis.

CAS No. 19983-44-9

サイズ	価格(税別)	在庫状況
10mM (1mL in DMSO)	JPY 29500	国内在庫あり
25mg	JPY 22000	国内在庫あり
100mg	JPY 55500	国内在庫あり
1g	JPY 145500	国内在庫なし(納期7~10日)

代表番号: 045-509-1970\|電子メール：[email protected] よく尋ねられる質問

文献中Selleckの製品使用例（238）

製品安全説明書

現在のバッチを見る：純度： 99.88%

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Stattic関連製品

関連ターゲット	STAT1 STAT3 STAT5 STAT6	もっと見る
関連化合物ライブラリー	Kinase Inhibitor Library FDA-approved Drug Library Natural Product Library Tyrosine Kinase Inhibitor Library JAK/STAT compound library	もっと見る

シグナル伝達経路

STATシグナル伝達経路

STAT阻害剤の選択性比較

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	活性情報	PMID
CNE2	Function Assay	0-20 μM	0-4 h	inhibits Stat3 activation in a dose- and time-dependent manner	23382914
CNE1	Function Assay	0-20 μM	0-4 h	inhibits Stat3 activation in a dose- and time-dependent manner	23382914
HONE1	Function Assay	20 µM	48 h	blocks the IL-6 increased phosphorylation of Stat3	23382914
CNE2	Function Assay	20 µM	48 h	blocks the IL-6 increased phosphorylation of Stat3	23382914
CNE1	Function Assay	20 µM	48 h	blocks the IL-6 increased phosphorylation of Stat3	23382914
T24	Function Assay	2/10/20 μM	24 h	causes dose-dependent inhibition of the CXCL12-induced increase of invading cells	23526079
SW837	Function Assay	2.5/10 μM	30 min	sensitizes cells to chemoradiotherapy in a dose-dependent manner	23934972
W480	Function Assay	2.5/10 μM	30 min	sensitizes cells to chemoradiotherapy in a dose-dependent manner	23934972
OV2008	Apoptosis Assay	0-10 μM	24/48 h	induces apoptosis in a dose and time dependent manner	23962558
C13*	Apoptosis Assay	0-10 μM	24/48 h	induces apoptosis in a dose and time dependent manner	23962558
HTR8/SVneo	Function Assay	1 μM	48 h	significantly increases migration by OSM	24060241
HTR8/SVneo	Function Assay	0.5/1 μM	48 h	restores the expression of E-cadherin suppressed by OSM	24060241
HTR8/SVneo	Function Assay	1 μM	1 h	suppressed OSM-induced STAT3 phosphorylation	24060241
HMECs	Function Assay	10 μM	2 h	inhibits IFNα mediated phosphorylation of STAT1, STAT2 and STAT3	24211327
MCF7-HER2	Growth Inhibition Assay	5 μM	24 h	enhances cell growth inhibition combined with Herceptin	24297508
MCF7-HER2	Function Assay	5 μM	24 h	decreases the expression levels of EMT markers, vimentin and slug	24297508
MCF7-HER2	Function Assay	5 μM	24 h	diminishes Sox-2, Oct-4, and slug expression	24297508
MCF7-HER2	Growth Inhibition Assay	0-10 μM	48 h	induces cell death dose dependently	24297508
SK-BR-3	Function Assay	10 µM	24 h	reduces P-STAT3 expression	24376586
SUM-159	Function Assay	10 µM	24 h	reduces P-STAT3 expression	24376586
MDA-MB-231	Function Assay	10 µM	24 h	reduces P-STAT3 expression	24376586
HaCaT	Apoptosis Assay	10 µM	20 min	enhances the apoptotic effects of everolimus	24423131
HaCaT	Growth Inhibition Assay	10 µM	20 min	enhances everolimus-induced cell growth inhibition	24423131
MCF-7/LCC9	Growth Inhibition Assay	0.469-3.75 μM	5 d	reduces cell number significantly	24728078
MCF-7/LCC1	Growth Inhibition Assay	0.469-3.75 μM	5 d	reduces cell number significantly	24728078
MCF-7	Growth Inhibition Assay	0.469-3.75 μM	5 d	reduces cell number significantly	24728078
CD4+	Apoptosis Assay	10 μm	24 h	induces apoptosis strongly	24756111
HuT-78	Cell Viability Assay	1-10 μM	72 h	causes a dose-dependent inhibition of the viability	24756111
SeAx	Cell Viability Assay	1-10 μM	72 h	causes a dose-dependent inhibition of the viability	24756111
SS	Cell Viability Assay	1-10 μM	72 h	causes a dose-dependent inhibition of the viability	24756111
ELL-primed hNSCs	Cell Viability Assay	0.02-5 μM	72 h	leads to the loss of cell viability at high concentration	24945434
FHL-primed hNSCs	Cell Viability Assay	0.02-5 μM	72 h	leads to the loss of cell viability at high concentration	24945434
HaCaT	Apoptosis Assay	10 µM	20 min	increases proportions of apoptotic cells due to treatment with sorafenib or sunitinib	25013907
Caki-1	Growth Inhibition Assay	10 µM	20 min	enhances sorafenib- and sunitinib-induced growth inhibition	25013907
HaCaT	Growth Inhibition Assay	10 µM	20 min	enhances sorafenib- and sunitinib-induced growth inhibition	25013907
H9c2	Function Assay	20 µM	30 min	abolishes propofol-induced AKT phosphorylation at both ser473 and thr308	25105067
MDA-MB-231	Function Assay	20 μM	2 h	exhibits Snail and E-cadherin expression	25153349
PC3M-1E8	Function Assay	10 μM	24 h	inhibits IL-6 induced STAT3 activation and the IL-6-induced STAT3 activation	25261365
PC3M-1E8	Function Assay	10 μM	24 h	downregulates Bcl-xL, survivin and c-Myc	25261365
PC3M-1E8	Function Assay	2.5/5/10 μM	0-4 h	inhibits the STAT3 activation in a dose- and time-dependent manner	25261365
ECA109	Function Assay	0.5 μM	24 h	enhances IR-induced generation of DSBs	25492480
KYSE150	Clonogenic Survival Assay	0.5 μM	24 h	suppresses the clonogenic formation	25492480
TE13	Clonogenic Survival Assay	0.5 μM	24 h	suppresses the clonogenic formation	25492480
ECA109	Clonogenic Survival Assay	0.5 μM	24 h	suppresses the clonogenic formation	25492480
KYSE150	Growth Inhibition Assay	0-20 μM	24 h	IC50=12.64 μM	25492480
TE13	Growth Inhibition Assay	0-20 μM	24 h	IC50=6.15 μM	25492480
ECA109	Growth Inhibition Assay	0-20 μM	24 h	IC50=5.50 μM	25492480
SiHa	Function Assay	5-75 nM	24 h	reduces the phosphorylation at the tyrosine residue 705	25539644
SiHa	Cell Viability Assay	5-75 nM	24 h	shows morphology of a typical apoptotic cell and dose-dependent loss of cell viability	25539644
A431	Growth Inhibition Assay	2 μM	2 h	increases in apoptosis induced by shikonin	25720435
A431	Growth Inhibition Assay	2 μM	2 h	blocks EGF-reversed decreases in cell viability	25720435
H9c2	Function Assay	2/10 μM	2 h	abrogates the cytoprotective effects of IL-27 against SH	25820907
HASMC	Function Assay	1.25-5 μM	20 min	inhibits p-(Y)-STAT-1,3,5 signals	25849622
H9c2	Function Assay	10 μM	4 h	reverses the effects of IL-27	26339633
HONE1	Function Assay	0-20 μM	0-4 h	inhibits Stat3 activation in a dose- and time-dependent manner	23382914
CNE1	Cell Viability Assay	0.5-64 μM	48 h	suppresses cell viability in a dose- and time-dependent manner	23382914
CNE2	Cell Viability Assay	0.5-64 μM	48 h	suppresses cell viability in a dose- and time-dependent manner	23382914
HONE1	Cell Viability Assay	0.5-64 μM	48 h	suppresses cell viability in a dose- and time-dependent manner	23382914
C666-1	Cell Viability Assay	0.5-64 μM	48 h	suppresses cell viability in a dose- and time-dependent manner	23382914
CNE1	Apoptosis Assay	10 µM	48 h	induces apoptosis	23382914
CNE2	Apoptosis Assay	10 µM	48 h	induces apoptosis	23382914
HONE1	Apoptosis Assay	10 µM	48 h	induces apoptosis	23382914
CNE2	Cell Viability Assay	1/2 μM	48 h	sensitize cells to radiotherapy	23382914
HONE1	Cell Viability Assay	1/2 μM	48 h	sensitize cells to radiotherapy	23382914
C666-1	Cell Viability Assay	1/2 μM	48 h	sensitize cells to radiotherapy	23382914
HEC-1A	Function Assay	1 μM	24 h	blocks the MUC20-enhanced invasion triggered by 10% FBS	23262208
RL95-2	Function Assay	1 μM	24 h	blocks the MUC20-enhanced invasion triggered by 10% FBS	23262208
HEC-1A	Function Assay	1 μM	24 h	blocks the MUC20-enhanced invasion triggered by EGF	23262208
RL95-2	Function Assay	1 μM	24 h	blocks the MUC20-enhanced invasion triggered by EGF	23262208
CT26	Function Assay	20 mM	1 h	suppresses HGF-induced VEGF expression	23233163
UM-SCC-17B	Function Assay	0-30 μM	0-24 h	inhibits STAT3 activation dose and time dependently	22770899
OSC-19	Function Assay	0-30 μM	0-24 h	inhibits STAT3 activation dose and time dependently	22770899
Cal33	Function Assay	0-30 μM	0-24 h	inhibits STAT3 activation dose and time dependently	22770899
UM-SCC-22B	Function Assay	0-30 μM	0-24 h	inhibits STAT3 activation dose and time dependently	22770899
U-87MG	Cell Viability Assay	0-10 μM	72 h	inhibits cell viability dose dependently	25436682
U-373MG	Cell Viability Assay	0-10 μM	72 h	inhibits cell viability dose dependently	25436682
SH-SY5Y	Cell Viability Assay	0-10 μM	72 h	inhibits cell viability dose dependently	25436682
Tu-9648	Cell Viability Assay	0-10 μM	72 h	inhibits cell viability dose dependently	25436682
Neuro-2a	Cell Viability Assay	0-10 μM	72 h	inhibits cell viability dose dependently	25436682
PCNs	Cell Viability Assay	0-10 μM	72 h	inhibits cell viability dose dependently	25436682
PGCs	Cell Viability Assay	0-10 μM	72 h	inhibits cell viability dose dependently	25436682
RAW264.7	Function Assay	10 μM	12 h	abrogates the mRNA expressions of JAK2, STAT1, STAT2, and STAT3 induced by DON and T-2 toxin	22454431
RAW264.7	Apoptosis Assay	5/10 μM	45 min	enhances toxins induced apoptosis and MMP loss	22454431
SW480	Cell Viability Assay	5/10/20 μM	72 h	inhibits cell viability of the ALDH+/CD133+ cells	21900397
HCT116	Cell Viability Assay	5/10/20 μM	72 h	inhibits cell viability of the ALDH+/CD133+ cells	21900397
DLD-1	Cell Viability Assay	5/10/20 μM	72 h	inhibits cell viability of the ALDH+/CD133+ cells	21900397
SNU387	Cell Viability Assay	20 μM	24 h	reduces cell viability	21311975
SNU398	Cell Viability Assay	20 μM	24 h	reduces cell viability	21311975
HepG2	Cell Viability Assay	20 μM	24 h	reduces cell viability	21311975
Huh-7	Cell Viability Assay	20 μM	24 h	reduces cell viability	21311975
VSMC	Growth Inhibition Assay	3/5/10 μM	30 min	prevents PDGF- and thrombin-mediated VSMC proliferation in a dose-dependent manner	20847306
MDA-MB-231	Apoptosis Assay	10 μM	24 h	induces apoptosis	17114005
MDA-MB-435S	Apoptosis Assay	10 μM	24 h	induces apoptosis	17114005
MDA-MB-231	Function assay	1 to 10 uM	12 hrs	Inhibition of STAT3 phosphorylation at Tyr705 in human MDA-MB-231 cells at 1 to 10 uM after 12 hrs by western blot analysis	24904966
MDA-MB-231	Anticancer assay	1 to 10 uM	48 hrs	Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition, apoptosis and cellular morphological changes at 1 to 10 uM after 48 hrs by light microscopy	24904966
MDA-MB-231	Function assay	1 to 10 uM	12 hrs	Decrease in STAT3 protein expression in human MDA-MB-231 cells at 1 to 10 uM after 12 hrs by western blot analysis	24904966
CNE1	Growth Inhibition Assay	4 μM		significantly reduces cell viability	23382914
PC3M-1E8	Clonogenic Survival Assay	2.5/5/10 μM		inhibits the colony formation significantly	25261365
NPC	Function Assay	0-7.5 µM		abolishes EMT-like molecular alterations, and cell migration and invasion induced by RKIP knockdown	25915430
OV2008	Apoptosis Assay		24/48 h	enhances cisplatin-induced apoptosis	23962558
C13*	Apoptosis Assay		24/48 h	enhances cisplatin-induced apoptosis	23962558
AsPC1	Antiproliferative assay		72 hrs	Antiproliferative activity against human AsPC1 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay, IC50 = 1.32 μM.	24904966
MDA-MB-231	Antiproliferative assay		72 hrs	Antiproliferative activity against ER-negative and triple-negative human MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay, IC50 = 2.89 μM.	24904966
MCF7	Antiproliferative assay		72 hrs	Antiproliferative activity against ER-positive human MCF7 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay, IC50 = 3.6 μM.	24904966
PANC1	Antiproliferative assay		72 hrs	Antiproliferative activity against human PANC1 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay, IC50 = 3.77 μM.	24904966
MDA-MB-231	Cytotoxicity assay		48 hrs	Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 1.56 μM.	26396689
MDA-MB-435S	Cytotoxicity assay		48 hrs	Cytotoxicity against human MDA-MB-435S cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 1.87 μM.	26396689
MCF7	Cytotoxicity assay		48 hrs	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 2.16 μM.	26396689
A549	Cytotoxicity assay		48 hrs	Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 2.5 μM.	26396689
DU145	Cytotoxicity assay		48 hrs	Cytotoxicity against human DU145 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 2.5 μM.	26396689
PANC1	Cytotoxicity assay		48 hrs	Cytotoxicity against human PANC1 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 2.9 μM.	26396689
HCT116	Antiproliferative assay		72 hrs	Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay, IC50 = 1.08 μM.	27718470
MDA-MB-231	Antiproliferative assay		72 hrs	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay, IC50 = 1.68 μM.	27718470
MCF7	Antiproliferative assay		72 hrs	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 2.36 μM.	27718470
A549	Antiproliferative assay		72 hrs	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay, IC50 = 4.4 μM.	27718470
AD293	Function assay		6 hrs	Inhibition of IFNgamma-stimulated GFP/FLAG-tagged STAT3 dimerization in human AD293 cells incubated for 6 hrs by Western blot analysis, IC50 = 5.1 μM.	30228000
MCF7	Function assay		12 hrs	Inhibition of STAT3 phosphorylation at Y705 in human MCF7 cells after 12 hrs by Western blot analysis	26396689
MDA-MB-435S	Function assay		12 hrs	Inhibition of STAT3 phosphorylation at Y705 in human MDA-MB-435S cells after 12 hrs by Western blot analysis	26396689
MDA-MB-231	Function assay		12 hrs	Inhibition of STAT3 phosphorylation at Y705 in human MDA-MB-231 cells after 12 hrs by Western blot analysis	26396689
UM-SCC-17B	Growth Inhibition Assay			IC50=2.562 ± 0.409 μM, GI50=1.279 ± 0.194 μM	22770899
OSC-19	Growth Inhibition Assay			IC50=3.481 ± 0.953 μM, GI50=1.366 ± 0.770 μM	22770899
Cal33	Growth Inhibition Assay			IC50=2.282 ± 0.423 μM, GI50=1.349 ± 0.363 μM	22770899
UM-SCC-22B	Growth Inhibition Assay			IC50=2.648 ± 0.542 μM, GI50=1.320 ± 0.204 μM	22770899
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生物活性

製品説明

Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1. Stattic induces apoptosis.

特性

Stattic is the first non-peptide small molecule with inhibitory activity against STAT3 SH2 domain regardless of the STAT3 phosphorylation state in vitro.

Targets

STAT3 ^[1]
(Cell-free assay)

5.1 μM

In Vitro
In vitro	Stattic inhibits binding of a phosphotyrosine-containing peptide derived from the gp130 receptor to the STAT3 SH2 domain in a strongly temperature-dependent manner. Stattic only has a very weak effect on binding of a tyrosinephosphorylated peptide to the SH2-domain of the tyrosine kinase Lck. And it doesn’t inhibit dimerization of two other dimeric transcription factors (c-Myc/Max and Jun/Jun). It also inhibits fluorescein-labeled phosphopeptides to the SH2 domains of STAT1 and STAT5b. Stattic selectively inhibits DNA binding of STAT3 homodimers at a concentration of 10 μM. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells). Stattic increases the apoptotic rate of STAT3-dependent breast cancer cell lines. ^[1]
Kinase Assay	High-Throughput Screening and FluorescencePolarization Assays
Kinase Assay	Screening is performed at approximately 30 °C. The specificity ofscreening hits is validated in analogous assays for binding of thetest compounds to the SH2 domains of STAT1, STAT5, and Lck. The final concentration of buffer components used for all FP assays is 10 mM HEPES (pH 7.5), 1 mM EDTA, 0.1% Nonidet P-40, 50 mM NaCl, and 10% DMSO. The absence of dithiothreitol is essential for inhibitory activity. The sequences of the peptides are: STAT3, 5-carboxyfluorescein-GY(PO₃H₂)LPQTV-NH₂; STAT1, 5-carboxyfluorescein-GY(PO₃H₂)DKPHVL; STAT5, 5-carboxyfluorescein-GY(PO₃H₂)LVLDKW; and Lck, 5-carboxyfluorescein-GY(PO₃H₂)EEIP. For specificity analysis at 30 °C, proteins are used at 150 nM (STAT1, STAT3, and STAT5). For specificity analysis at 37 °C, proteins are used at 370 nM (STAT3) or 100 nM (Lck). Proteins are incubated with test compounds in Eppendorf tubes at the indicated temperatures for 60 min prior addition of therespective 5-carboxyfluorescein labeled peptides (final concentration: 10 nM).Before measurement at room temperature, the mixtures are allowed to equilibrate for at least 30 min. Test compounds are used at the indicated concentrations diluted from a 20× stock in DMSO. Binding curves and inhibition curves are fitted with SigmaPlot. All competition curves are repeated three times in independent experiment
細胞実験	細胞株	Ly3 cells
	濃度	~2.5 μM
	反応時間	48 h
	実験の流れ	MTS
実験結果図	Methods	Biomarkers	結果図	PMID
	Western blot	PARP / C-PARP / Caspase-3 / C-Caspse-3 Survivin / c-Myc / Bcl-xl p-STAT3 / STAT3		23382914
	Immunofluorescence	p-STAT3 / STAT3 / Survivin		25261365
	Growth inhibition assay	Cell viability		23382914
	ELISA	BDNF		27456333

参考
[1] Schust J, et al. Chem Biol, 2006, 13(11), 1235-1242. [2] Scuto A, et al. Cancer Res, 2011, 71(9), 3182-3188.

参考

化学情報

分子量	211.19	化学式	C₈H₅NO₄S
CAS No.	19983-44-9	SDF	Download Stattic SDFをダウンロードする
Smiles	C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]
保管	3年-20°C粉	溶液の保管冷凍と解凍の繰り返しを避けるため小分けにしてください	1年-80°Cin solvent
保管	3年-20°C粉	溶液の保管冷凍と解凍の繰り返しを避けるため小分けにしてください	1个月-20°Cin solvent

In vitro
Batch:

DMSO : 42 mg/mL ( (198.87 mM)；吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。)

Water : Insoluble

Ethanol : Insoluble

モル濃度計算器

in vivo Batch: Add solvents to the product individually and in order.					投与溶液組成計算機
	Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O	1.0mg/ml	Taking the 1 mL working solution as an example, add 50 μL of 10.9 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to make it clear. Volume up to 1 mL. The mixed solution should be used immediately for optimal results.	投与溶液組成計算機
Clear solution	5% DMSO 1 95% Corn oil	0.8mg/ml	Taking the 1 mL working solution as an example, add 50 μL of 16 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Clear solution	10%DMSO 1 40%PEG300 2 5%Tween80 3 45%ddH2O	4.8mg/ml	Taking the 1 mL working solution as an example, add 100 μL of 48 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to make it clear; then continue to add 450 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

実験計算

モル濃度計算器

質量	濃度	体積	分子量
=	×	×

希釈計算器分子量計算器

投与溶液組成計算機(クリア溶液)

ステップ１：実験データを入力してください。（実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します）

投与量 mg/kg 動物平均体重 g 投与体積（動物毎）μL 動物数匹

ステップ２：投与溶媒の組成を入力してください。（ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください）

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

計算結果：

投与溶媒濃度： mg/ml;

DMSOストック溶液調製方法： mg 試薬を μL DMSOに溶解する（濃度 mg/mL, 注：濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。 )

投与溶媒調製方法：Take μL DMSOストック溶液に μL PEG300，を加え、完全溶解後μL Tween 80，を加えて完全溶解させた後 μL ddH₂O，を加え完全に溶解させます。

投与溶媒調製方法：μL DMSOストック溶液に μL Corn oil，を加え、完全溶解。

注意：１.ストック溶液に沈殿、混濁などがないことをご確認ください；
２.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):