Tocilizumab (anti-IL-6R)

製品コードA2012 別名: MRA

製品コード：A2012 純度：99%

Tocilizumab is a humanized monoclonal antibody that binds to the interleukin-6 receptor, MW: 148 KD.

サイズ	価格(税別)	在庫状況
1mg	JPY 44500	国内在庫あり
1mg*5	JPY 146500	お問い合わせ
1mg*25	JPY 445500	お問い合わせ

代表番号: 045-509-1970\|電子メール：[email protected] よく尋ねられる質問

文献中Selleckの製品使用例（41）

質量管理及び製品安全説明書

現在のバッチを見る：純度： 99% タンパク質濃度： 14.29mg/ml 内毒素：＜1EU/mg

IL Receptor阻害剤の選択性比較

生物活性

製品説明

Tocilizumab is a humanized monoclonal antibody that binds to the interleukin-6 receptor, MW: 148 KD.

同型

Human IgG1

Targets

IL-6R ^[1]

In Vitro
In Vitro	After adding tocilizumab at different concentrations into HMO6 and CHME5 cells stimulated by F3-CM or with IL6, the expression levels of anti-inflammatory M2 markers (CD206 and Arg1) are decreased, as well as the levels of both phosphorylated JAK2 and STAT3.^[1]
細胞実験	HMO6 and CHME5 cells with control media or F3-CM alone or F3-CM were treated with Tocilizumab (2.5 μg/ml for 24 h) or with IL6 (200 ng/ml for 24 h) alone or IL6-supplemented with Tocilizumab. Western blot analysis of p-JAK2, JAK2, p-STAT3, and STAT3 in HMO6 and CHME5 cells were conducted.

In Vivo
In Vivo	Tocilizumab can block JAK2/STAT3 activation and impede brain metastasis (BM) of A549-F3 cells in vivo.^[1]
動物試験	Animal Models: Nude mice of brain metastasis models Dosages: 5 mg/kg Administration: i.p. Reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864012/

参考
[1] Jin Y, et al. Signal Transduct Target Ther. 2022 Feb 23;7(1):52.

参考

[1] Jin Y, et al. Signal Transduct Target Ther. 2022 Feb 23;7(1):52.

製品説明

CAS No.	‎375823-41-9
Formulation	PBS buffer, pH 7.2
Isotype	Human IgG1
Source	CHO cells
Storage (From the date of receipt)	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles
Shipping	Shipped under low temperature conditions
Sterility	5 mg/ml

技術サポート

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Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

* 必須

よくある質問（FAQ）

質問：1：
How to store the antibody?

回答：
Store the undiluted solution at 4 °C in the dark. Freezing antibodies can result in a loss of activity caused by the freezing/thawing process. Diluting antibodies to working concentrations and storing at 4°C for more than a day should be avoided. Additionally, make sure to keep the antibody sterile. Under these storage conditions, your antibodies should remain active for up to one year and oftentimes longer.