CCR

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S2907 Pirfenidone <1 mg/mL 37 mg/mL '37 mg/mL
S2003 Maraviroc <1 mg/mL 100 mg/mL '100 mg/mL
S6555 AZD2098 <1 mg/mL 67 mg/mL 5 mg/mL
S0129 SB-297006 <1 mg/mL 68 mg/mL '''20 mg/mL
S8501 Adaptavir (DAPTA) 100 mg/mL -1 mg/mL -1 mg/mL
S8324 ZK756326 2HCl 78 mg/mL 39 mg/mL 4 mg/mL

CCR製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S2907

Pirfenidone

Pirfenidone is an inhibitor for TGF-β production and TGF-β stimulated collagen production, reduces production of TNF-α and IL-1β, and also has anti-fibrotic and anti-inflammatory properties. Pirfenidone attenuates chemokine (CC motif) ligand-2 (CCL2) and CCL12 production with anti-fibrotic activity. Phase 3.

S2003

Maraviroc

Maraviroc is a CCR5 antagonist for MIP-1α, MIP-1β and RANTES with IC50 of 3.3 nM, 7.2 nM and 5.2 nM in cell-free assays, respectively. Maraviroc is used in the treatment of HIV infection.

S6555

AZD2098

AZD2098 is a potent and bioavailable CCR4 receptor antagonist with pIC50 of 7.8.

S0129

SB-297006

SB-297006 is an antagonist of C-C chemokine receptor 3 (CCR3) that suppresses antigen-induced accumulation of T(h)2 as well as eosinophils in the lungs. SB-297006 suppressed CCL11-induced Th2 chemotaxis with IC50 of 2.5 μM.

S8501

Adaptavir (DAPTA)

DAPTA is a water soluble potent, selective CCR5 antagonist which potently inhibits specific CD4-dependent binding of gp120 Bal (IC50 = 0.06 nM) and CM235 (IC50 = 0.32 nM) to CCR5.

S8324

ZK756326 2HCl

ZK756326 is a full agonist of CCR8(Chemokine receptor 8) with an IC50 of 1.8 μM, dose-responsively eliciting an increase in intracellular calcium and cross-desensitizing the response of the receptor to CCL1.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S2907

Pirfenidone

Pirfenidone is an inhibitor for TGF-β production and TGF-β stimulated collagen production, reduces production of TNF-α and IL-1β, and also has anti-fibrotic and anti-inflammatory properties. Pirfenidone attenuates chemokine (CC motif) ligand-2 (CCL2) and CCL12 production with anti-fibrotic activity. Phase 3.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S2003

Maraviroc

Maraviroc is a CCR5 antagonist for MIP-1α, MIP-1β and RANTES with IC50 of 3.3 nM, 7.2 nM and 5.2 nM in cell-free assays, respectively. Maraviroc is used in the treatment of HIV infection.

2020, 22;6(21):eaaz8521

2020, 28

2020, 13;molcanther11722019

S6555

AZD2098

AZD2098 is a potent and bioavailable CCR4 receptor antagonist with pIC50 of 7.8.

S0129

SB-297006

SB-297006 is an antagonist of C-C chemokine receptor 3 (CCR3) that suppresses antigen-induced accumulation of T(h)2 as well as eosinophils in the lungs. SB-297006 suppressed CCL11-induced Th2 chemotaxis with IC50 of 2.5 μM.

S8501

Adaptavir (DAPTA)

DAPTA is a water soluble potent, selective CCR5 antagonist which potently inhibits specific CD4-dependent binding of gp120 Bal (IC50 = 0.06 nM) and CM235 (IC50 = 0.32 nM) to CCR5.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S8324

ZK756326 2HCl

ZK756326 is a full agonist of CCR8(Chemokine receptor 8) with an IC50 of 1.8 μM, dose-responsively eliciting an increase in intracellular calcium and cross-desensitizing the response of the receptor to CCL1.

2019, 216(12):2763-2777