Allopurinol

製品コードS1630 バッチS163002

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C5H4N4O
分子量 136.11 CAS No. 315-30-0
Solubility (25°C)* 体外 DMSO 27 mg/mL (198.36 mM)
Ethanol 3 mg/mL (22.04 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Allopurinol is a purine analog inhibitor of the enzyme xanthine oxidase, used to treat gout or kidney stones, and to decrease levels of uric acid.
in vitro Allopurinol reverses the increased xanthine oxidase activity in ischemia-reperfusion injury of neonatal rat hearts. This compound (10 mM) treatment suppresses xanthine oxidase activity induced by hypoxia-reoxygenation injury and the production of reactive oxygen species. It also decreases the concentration of intracellular Ca2+ increased by enhanced xanthine oxidase activity. [1]
in vivo Allopurinol shows abnormal pyrimidine metabolism together with renal toxicity which could be ameliorated by uridine, indicating that this compound essentially causes pyrimidine metabolism abnormality leading to renal impairment in normal mice. It increases urinary OD excretion to an extent similar to that in normal mice administered the same dose of this chemical in DNFB-sensitized mice. [2] This compound promotes a clinical improvement which is accompanied by a reduction in the parasitic load in the blood, skin and lymph nodes but, even after long period of allopurinol administration alone, Leishmania may persist in dog tissues in Leishmania-infected dogs. [3] It prevents early alcohol-induced liver injury in rats, most likely by preventing oxidant-dependent activation of NF-kappaB. [4] This chemical protects dose-dependently against acetaminophen-induced cell injury, the loss of ATP and the increase of the GSSG content in the total liver and in the mitochondrial compartment without inhibiting reactive metabolite formation in mice. It almost completely inhibits hepatic xanthine oxidase and dehydrogenase activity, but only high doses prevents the increase of the mitochondrial GSSG content. [5]

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/16516885/
  • https://pubmed.ncbi.nlm.nih.gov/10823345/
  • https://pubmed.ncbi.nlm.nih.gov/17553711/
  • https://pubmed.ncbi.nlm.nih.gov/10734182/
  • https://pubmed.ncbi.nlm.nih.gov/2262912/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Intervertebral disk regeneration in a rat model by allopurinol–loaded chitosan/alginate hydrogel [ Biomaterials, 2023, 23(4)] PubMed: None
Hypoxia-induced TMTC3 expression in esophageal squamous cell carcinoma potentiates tumor angiogenesis through Rho GTPase/STAT3/VEGFA pathway [ J Exp Clin Cancer Res, 2023, 42(1):249] PubMed: 37752569
Hypoxia-induced TMTC3 expression in esophageal squamous cell carcinoma potentiates tumor angiogenesis through Rho GTPase/STAT3/VEGFA pathway [ J Exp Clin Cancer Res, 2023, 42(1):249] PubMed: 37752569
Spatiotemporal Regulation of De Novo and Salvage Purine Synthesis during Brain Development [ eNeuro, 2023, 10(10)ENEURO.0159-23.2023] PubMed: 37770184
Intervertebral disk regeneration in a rat model by allopurinol-loaded chitosan/alginate hydrogel [ Biomol Biomed, 2023, 23(4):661-670] PubMed: 36786280
Establishment and Characterization of NCC-PMP1-C1: A Novel Patient-Derived Cell Line of Metastatic Pseudomyxoma Peritonei [ J Pers Med, 2022, 12(2)258] PubMed: 35207746
Establishment and characterization of NCC-UPS4-C1: a novel cell line of undifferentiated pleomorphic sarcoma from a patient with Li-Fraumeni syndrome [ Hum Cell, 2022, 10.1007/s13577-022-00671-y] PubMed: 35118583
ELUCIDATING THE BIOLOGICAL ROLES OF ADP-RIBOSYLATION WITH CHEMICAL TOOLS [ Johns Hopkins University, 2022, ] PubMed: None
Metabolic Changes Are Associated with Melphalan Resistance in Multiple Myeloma [ J Proteome Res, 2021, 20(6):3134-3149] PubMed: 34014671
Establishment and characterization of NCC-MFS4-C1: a novel patient-derived cell line of myxofibrosarcoma [ Hum Cell, 2021, 34(6):1911-1918] PubMed: 34383271

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。