Meloxicam

製品コードS1734 バッチS173401

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C14H13N3O4S2
分子量 351.4 CAS No. 71125-38-7
Solubility (25°C)* 体外 DMSO 30 mg/mL (85.37 mM)
Water Insoluble
Ethanol Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O

この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。

 1.000mg/ml (2.85mM) Taking the 1 mL working solution as an example, add 50 μL of 20 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution
5% DMSO 95% Corn oil

この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。

 0.200mg/ml (0.57mM) Taking the 1 mL working solution as an example, add 50 μL of 4 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Meloxicam is a selective COX inhibitor, used to relieve pain and fever effects.
in vitro Meloxicam significantly reduces HCA-7 and Moser-S colony size. This compound significantly inhibits HCA-7 colony and tumor growth but has no effect on the growth of the COX-2 negative HCT-116 cells. [1] It inhibits PGE(2) production, proliferation and invasiveness especially in MG-63 cells, which express relatively high levels of COX-2. This chemical causes apoptosis and upregulates Bax mRNA and protein in MG-63 cell culture. [2]
in vivo Meloxicam suppresses LM-8 tumor growth and lung metastasis in vivo mouse model. [2] This compound causes a significant reduction in lameness at post injection hour (PIH) 8 and 24 and tends to reduce effusion in horse. It significantly suppresses synovial fluid (SF) prostaglandin E2 and substance P release at PIH 8 and bradykinin at PIH 24 compared to placebo treatment in horse. This agent reduces general MMP activity at PIH 8 and 24 in horse. [3] This compound- or flunixin-treated horses has improved postoperative pain scores and clinical variables, compared with SS-treated horses. It results in high numbers of neutrophils in ischemia-injured tissue of horse. [4] Its administration significantly suppresses PGE2 concentrations in blood and synovial fluid at days 7 and 21, but has no effect on concentrations of TXB2 in blood or PGE2 in gastric mucosa in dogs. [5]

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/9886578/
  • https://pubmed.ncbi.nlm.nih.gov/16219634/
  • https://pubmed.ncbi.nlm.nih.gov/19927589/
  • https://pubmed.ncbi.nlm.nih.gov/17542694/
  • https://pubmed.ncbi.nlm.nih.gov/12428662/

カスタマーフィードバック

Data from [Data independently produced by , , Oncology letters, 2017, 2198-2206]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Meloxicam inhibits STING phosphorylation and alleviates intracellular DNA-mediated autoimmune responses [ Cell Biosci, 2023, 13(1):76] PubMed: 37120570
Meloxicam Inhibits Hepatocellular Carcinoma Progression and Enhances the Sensitivity of Immunotherapy via the MicroRNA-200/PD-L1 Pathway [ J Oncol, 2022, 2022:4598573] PubMed: 35237322
Characterization of six canine prostate adenocarcinoma and three transitional cell carcinoma cell lines derived from primary tumor tissues as well as metastasis. [ PLoS One, 2020, 13;15(3):e0230272] PubMed: 32168360
Meloxicam decreases the migration and invasion of CF41.Mg canine mammary carcinoma cells. [Iturriaga MP, et al. Oncol Lett, 2017, 14(2):2198-2206] PubMed: 28781660

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。