BMS-833923

製品コードS7138 バッチS713802

印刷

化学情報

Chemical Structure Synonyms XL139 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C30H27N5O
分子量 473.57 CAS No. 1059734-66-5
Solubility (25°C)* 体外 DMSO 95 mg/mL (200.6 mM)
Water Insoluble
Ethanol Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 BMS-833923 (XL139) is an orally bioavailable Smoothened antagonist. Phase 2.
in vitro BMS-833923 reduces hedgehog pathway activity, decreases cell proliferation and induces apoptosis via the intrinsic pathway in esophageal adenocarcinoma (EAC) cell lines. [2] This compound dose-dependently affects canonical and prostate hedgehog signature gene transcription in vitro. [3]

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/22177102/
  • https://pubmed.ncbi.nlm.nih.gov/23915072/
  • https://pubmed.ncbi.nlm.nih.gov/24105601/

カスタマーフィードバック

Data from [Data independently produced by , , Neoplasia, 2015, 17(7):538-51.]

Data from [Data independently produced by , , Sci Rep, 2017, 7(1):1899]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Establishment and characterization of immortalized sweat gland myoepithelial cells [ Sci Rep, 2022, 12(1):7] PubMed: 34997030
Quantitative longitudinal imaging reveals that inhibiting Hedgehog activity alleviates the hypoxic tumor landscape [ Mol Cancer Res, 2021, molcanres.MCR-21-0257-A.2021] PubMed: 34593607
A novel human colon signet-ring cell carcinoma organoid line: establishment, characterization and application [ Carcinogenesis, 2020, 41(7):993-1004] PubMed: 31740922
Hedgehog Signaling Inhibition by Smoothened Antagonist BMS-833923 Reduces Osteoblast Differentiation and Ectopic Bone Formation of Human Skeletal (Mesenchymal) Stem Cells. [ Stem Cells Int, 2019, 2019:3435901] PubMed: 31871467
Inhibition of Gli leads to antitumor growth and enhancement of cisplatin-induced cytotoxicity in large cell neuroendocrine carcinoma of the lung [Ishiwata T Oncol Rep, 2018, 1148-1154] PubMed: 29328464
Disruption of SHH signaling cascade by SBE attenuates lung cancer progression and sensitizes DDP treatment. [Du J, et al. Sci Rep, 2017, 7(1):1899] PubMed: 28507311
Gli1-Mediated Regulation of Sox2 Facilitates Self-Renewal of Stem-Like Cells and Confers Resistance to EGFR Inhibitors in Non-Small Cell Lung Cancer [Bora-Singhal N, et al. Neoplasia, 2015, 17(7):538-51] PubMed: 26297432

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。