Dibutyryl cAMP (Bucladesine) sodium

製品コードS7858 バッチS785810

印刷

化学情報

Chemical Structure Synonyms DBcAMP sodium salt Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C18H23N5NaO8P
分子量 491.37 CAS No. 16980-89-5
Solubility (25°C)* 体外 DMSO (warmed with 50ºC water bath) 98 mg/mL (199.44 mM)
Water (warmed with 50ºC water bath) 98 mg/mL (199.44 mM)
Ethanol (warmed with 50ºC water bath) 25 mg/mL (50.87 mM)
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Bucladesine sodium is a cell-permeable PKA activator by mimicing the action of endogenous cAMP. Dibutyryl-cAMP (Bucladesine) is also a phosphodiesterase (PDE) inhibitor.
in vitro

Dibutyryl-cAMP inhibits neuronal glucose uptake via PKA activation. [1]

In cultured rat hepatocytes, Dibutyryl-cAMP inhibits inducible nitric oxide synthase expression and NF-kappaB-binding activity. [2]

Dibutyryl-cAMP also suppress TNFalpha-induced hepatocyte apoptosis by inhibiting FADD up-regulation. [3]
in vivo

In a mouse model, bucladesine (600 nM/mouse, i.p.) reverses zinc chloride- and lead acetate-induced avoidance memory retention impairments. [4]

プロトコル(参考用のみ)

細胞アッセイ 細胞株 PC12 cells
濃度 1 mM
反応時間 24 h
実験の流れ

Cells were incubated with 1 mM of db-cAMP.
動物実験 動物モデル Mice
投薬量 600 nM/mouse
投与方法 i.p.

参考

  • https://pubmed.ncbi.nlm.nih.gov/11161593/
  • https://pubmed.ncbi.nlm.nih.gov/11469895/
  • https://pubmed.ncbi.nlm.nih.gov/16538385/
  • https://pubmed.ncbi.nlm.nih.gov/26066527/
  • https://pubmed.ncbi.nlm.nih.gov/22302126/
  • https://pubmed.ncbi.nlm.nih.gov/9721736/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Regulation of inflammatory responses by pH-dependent transcriptional condensates [ Cell, 2025, S0092-8674(25)00735-4] PubMed: 40680734
Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress [ Nat Neurosci, 2025, 28(6):1174-1184] PubMed: 40456907
Adipocyte CLDN5 promotes thermogenesis and energy expenditure through regulation of IL10 expression [ Nat Commun, 2025, 16(1):6151] PubMed: 40610440
α-synuclein fibrils per se but not α-synuclein seeded aggregation causes mitochondrial dysfunction and cell death in human neurons [ Redox Biol, 2025, 86:103817] PubMed: 40812158
Evaluating endometrial response to human chorionic gonadotropin: alterations in epigenetic regulation and extracellular vesicle cargo of endometrial stromal cells [ Hum Reprod Open, 2025, 2025(3):hoaf051] PubMed: 40919059
Repression of varicella zoster virus gene expression during quiescent infection in the absence of detectable histone deposition [ PLoS Pathog, 2025, 21(2):e1012367] PubMed: 39928684
Establishment of reproducible method for production of cultured epidermal sheets with controlled melanocyte density [ Regen Ther, 2025, 29:499-505] PubMed: 40395371
RNA triggers chronic stress during neuronal aging [ bioRxiv, 2025, 2025.08.04.668575] PubMed: 40799579
Control of Inflammatory Response by Tissue Microenvironment [ bioRxiv, 2025, 2024.05.10.592432] PubMed: 38798655
Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation [ Cell Rep Med, 2024, 5(3):101477] PubMed: 38508143

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。