Luteolin

製品コードS2320 バッチS232005

印刷

化学情報

Synonyms

Luteoline, Luteolol, Digitoflavone

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₅H₁₀O₆

分子量

286.24

CAS No.

491-70-3

Solubility (25°C)*

体外

DMSO

57 mg/mL (199.13 mM)

Ethanol (warmed with 50ºC water bath)

20 mg/mL (69.87 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	2.850mg/ml (9.96mM)	Taking the 1 mL working solution as an example, add 50 μL of 57 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	0.350mg/ml (1.22mM)	Taking the 1 mL working solution as an example, add 50 μL of 7 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Luteolin (Luteoline, Luteolol, Digitoflavone) is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively.
in vitro	Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. ^[1] This compound inhibits LPS-stimulated TNF-alpha production with an IC50 of less than 1 μM. It inhibites LPS-induced phosphorylation of Akt as well as IkappaBalpha. ^[2]
in vivo	LD50: Mice >2500mg/kg (i.g.) ^[3]

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/19853596/
https://pubmed.ncbi.nlm.nih.gov/11123379/

カスタマーフィードバック

: , , Mol Nutr Food Res, 2017, doi: 10.1002/mnfr.201600744

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Luteolin ameliorates periodontitis by modulating mitochondrial dynamics and macrophage polarization via the JAK2/STAT3 pathway [ Int Immunopharmacol, 2025, 144:113612]	PubMed: 39579538
Luteolin attenuates LPS-induced damage in IPEC-J2 cells by enhancing mitophagy via AMPK signaling pathway activation [ Front Nutr, 2025, 12:1552890]	PubMed: 40206944
Luteolin as an adjuvant effectively enhanced the efficacy of adoptive tumor-specific CTLs therapy [ BMC Cancer, 2025, 25(1):411]	PubMed: 40050776
CB-5083 and luteolin synergistically induce the apoptosis of bladder cancer cells via multiple mechanisms [ Toxicol Appl Pharmacol, 2025, 499:117333]	PubMed: 40194745
Luteolin alleviated calcium oxalate crystal induced kidney injury by inhibiting Nr4a1-mediated ferroptosis [ Phytomedicine, 2024, 136:156302]	PubMed: 39662099
Mutant p53 protects triple-negative breast adenocarcinomas from ferroptosis in vivo [ Sci Adv, 2024, 10(7):eadk1835]	PubMed: 38354236
Differential regulation of H3K9/H3K14 acetylation by small molecules drives neuron-fate-induction of glioma cell [ Cell Death Dis, 2023, 14(2):142]	PubMed: 36805688
Luteolin inhibits herpes simplex virus 1 infection by activating cyclic guanosine monophosphate-adenosine monophosphate synthase-mediated antiviral innate immunity [ Phytomedicine, 2023, 120:155020]	PubMed: 37632997
Niaoduqing alleviates podocyte injury in high glucose model via regulating multiple targets and AGE/RAGE pathway: Network pharmacology and experimental validation [ Front Pharmacol, 2023, 14:1047184]	PubMed: 36923354
Niaoduqing alleviates podocyte injury in high glucose model via regulating multiple targets and AGE/RAGE pathway: Network pharmacology and experimental validation [ Front Pharmacol, 2023, 14:1047184]	PubMed: 36923354

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。