NDI-091143

製品コードS8878 バッチS887802

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
化学式

C20H14ClF2NO5S
分子量 453.84 CAS No. 2375840-87-0
Solubility (25°C)* 体外 Ethanol 5 mg/mL (11.01 mM)
DMSO 3 mg/mL (6.61 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 NDI-091143 is a potent inhibitor of human ATP-citrate lyase(ACLY) with a Ki of 7.0 nM and an IC50 of 2.1 nM in the ADP-Glo assay.
in vitro

ACLY inhibitor NDI091143 exerts dose-dependent inhibition of T24 and T24T clonogenic survival. [1]

プロトコル(参考用のみ)

細胞アッセイ 細胞株 BCa cell lines (UMUC3, T24, T24T)
濃度 5-100 μM
反応時間 10–14 days
実験の流れ

BCa cells are plated in wells of 6-well plates at a density of 500 cells/ well, and allowed to attach for 16 h, before being treated with NDI091143 for further 10–14 days. Formation of cell colonies > 50 cells/colony is confirmed by examination under inverted microscope. Plates are then fixed with 4% paraformaldehyde and are stained with crystal violet.

参考

  • https://pubmed.ncbi.nlm.nih.gov/34764423/
  • https://pubmed.ncbi.nlm.nih.gov/30944472/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Oncogene-induced senescence mitochondrial metabolism and bioenergetics drive the secretory phenotype: further characterization and comparison with other senescence-inducing stimuli [ Redox Biol, 2025, 82:103606] PubMed: 40158257
ATP-Citrate Lyase Supports Cardiac Function and NAD+/NADH Balance and Is Depressed in Human Failing Myocardium [ JACC Basic Transl Sci, 2025, 10(7):101301] PubMed: 40499285
Glycerol Kinase Drives Hepatic de novo Lipogenesis and Triglyceride Synthesis in Nonalcoholic Fatty Liver by Activating SREBP-1c Transcription, Upregulating DGAT1/2 Expression, and Promoting Glycerol Metabolism [ Adv Sci (Weinh), 2024, 11(46):e2401311] PubMed: 39418169
Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells [ Cancer Commun (Lond), 2022, 42(8):716-749] PubMed: 35838183
Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells [ Cancer Commun (Lond), 2022, 10.1002/cac2.12332] PubMed: 35838183
ACLY inhibitors induce apoptosis and potentiate cytotoxic effects of sorafenib in thyroid cancer cells [ Endocrine, 2022, 10.1007/s12020-022-03124-6] PubMed: 35761130
Metabolomic credentialing of murine carcinogen-induced urothelial cancer [ Sci Rep, 2021, 11(1):22085] PubMed: 34764423

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。