Retinoic acid (Tretinoin, Vitamin A acid)

製品コードS1653 バッチS165307

印刷

化学情報

Synonyms

All-trans Retinoic Acid, ATRA, Vitamin A acid,NSC 122758

Storage
(From the date of receipt)

3 years -20°C(in the dark) powder

化学式

C₂₀H₂₈O₂

分子量

300.4

CAS No.

302-79-4

Solubility (25°C)*

体外

DMSO

60 mg/mL (199.73 mM)

Ethanol

5 mg/mL (16.64 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Retinoic acid (Tretinoin), which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.Tretinoin (NSC 122758) can be used to induce animal models of Osteoporosis.
in vitro	Retinoic acid (Tretinoin, Vitamin A acid) prevents the cytotoxicity of H2O2 in cultured human mesangial cells by increasing both the catalase activity and the reduced glutathione content, which are dose- and time-dependent changes. It also leads to increased levels of catalase mRNA and gamma-glutamyl-cysteine synthetase (catalytic subunit) mRNA, the latter being the rate-limiting step in de novo reduced glutathione synthesis. ^[1] This compound upregulates matrix metalloproteinase-13 and matrix metalloproteinase-8 in human keloid-derived fibroblasts. ^[2]
in vivo	Retinoic acid (Tretinoin, Vitamin A acid) has the ability to prevent the major steroid-induced biomechanical changes in hairless mouse dermal connective tissue that contribute to atrophy. ^[3] It combined with imiquimod leads to faded tattoos and moderate clearance of pigment on histopathology in the guinea pig. ^[4] This compound increases fibroplastic proliferation in the Skin incisions were made in 45 CD-1 mice, but the production of collagen was diminished. ^[5] Tretinoin-treated old male Fischer 344 rats have 30% lower protein content in the renal cortex than control old rats, this effect may depend on the inhibition of the expression of tumor necrosis factor-beta1, a matrigenic cytokine, and osteopontin, a protein with cell adhesive and chemotactic properties. ^[1]

製品説明

Retinoic acid (Tretinoin), which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.Tretinoin (NSC 122758) can be used to induce animal models of Osteoporosis.

in vitro

Retinoic acid (Tretinoin, Vitamin A acid) prevents the cytotoxicity of H2O2 in cultured human mesangial cells by increasing both the catalase activity and the reduced glutathione content, which are dose- and time-dependent changes. It also leads to increased levels of catalase mRNA and gamma-glutamyl-cysteine synthetase (catalytic subunit) mRNA, the latter being the rate-limiting step in de novo reduced glutathione synthesis. ^[1]

This compound upregulates matrix metalloproteinase-13 and matrix metalloproteinase-8 in human keloid-derived fibroblasts. ^[2]

in vivo

Retinoic acid (Tretinoin, Vitamin A acid) has the ability to prevent the major steroid-induced biomechanical changes in hairless mouse dermal connective tissue that contribute to atrophy. ^[3]

It combined with imiquimod leads to faded tattoos and moderate clearance of pigment on histopathology in the guinea pig. ^[4]

This compound increases fibroplastic proliferation in the Skin incisions were made in 45 CD-1 mice, but the production of collagen was diminished. ^[5]

Tretinoin-treated old male Fischer 344 rats have 30% lower protein content in the renal cortex than control old rats, this effect may depend on the inhibition of the expression of tumor necrosis factor-beta1, a matrigenic cytokine, and osteopontin, a protein with cell adhesive and chemotactic properties. ^[1]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	BE2C cells
	濃度	5 μM
	反応時間	6 days
	実験の流れ	Retinoic acid (Tretinoin, Vitamin A acid) was used to treat cells at the indicated concentration for 6 days.
動物実験	動物モデル	Female Skh-hairless-1 albino mice
	投薬量	0.05%
	投与方法	Dorsal application

参考

https://pubmed.ncbi.nlm.nih.gov/10086995/
https://pubmed.ncbi.nlm.nih.gov/14756522/
https://pubmed.ncbi.nlm.nih.gov/8106754/

https://pubmed.ncbi.nlm.nih.gov/11998793/
https://pubmed.ncbi.nlm.nih.gov/15793506/
https://pubmed.ncbi.nlm.nih.gov/34669465/
https://pubmed.ncbi.nlm.nih.gov/7706770/
https://pubmed.ncbi.nlm.nih.gov/27078158/
https://pubmed.ncbi.nlm.nih.gov/12963727/
https://pubmed.ncbi.nlm.nih.gov/1323127/

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カスタマーフィードバック

: Data from [Data independently produced by , , Cell, 2018, 175(5):1244-1258]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

CPSF6-RARγ interacts with histone deacetylase 3 to promote myeloid transformation in RARG-fusion acute myeloid leukemia [ Nat Commun, 2025, 16(1):616]	PubMed: 39805830
Construction of human pluripotent stem cell-derived testicular organoids and their use as humanized testis models for evaluating the effects of semaglutide [ Theranostics, 2025, 15(6):2597-2623]	PubMed: 39990223
Extracellular lactate improves neurogenesis by modulating H3K9 lactylation and SnoN expression under hypoxic conditions [ Stem Cell Res Ther, 2025, 16(1):462]	PubMed: 40866997
Human epicardial organoids from pluripotent stem cells resemble fetal stage with potential cardiomyocyte- transdifferentiation [ Cell Biosci, 2025, 15(1):4]	PubMed: 39825425
Study of Retinoic Acid-Induced Osteoarthritis: Integrating RNA-Sequencing, Network Pharmacology, Molecular Docking, and Experimental Validation [ Int J Mol Sci, 2025, 26(12)5519]	PubMed: 40564983
Potassium Iodide Induces Apoptosis in Salivary Gland Cancer Cells [ Int J Mol Sci, 2025, 26(11)5199]	PubMed: 40508009
Modelling myocardial ischemia/reperfusion injury with inflammatory response in human ventricular cardiac organoids [ Cell Prolif, 2024, e13762.]	PubMed: 39377453
Patient-derived rhabdomyosarcoma cells recapitulate the genetic and transcriptomic landscapes of primary tumors [ iScience, 2024, 27(10):110862]	PubMed: 39319271
The Effect of Retinoic Acid on Arsenite-Transformed Malignant UROtsa Bladder Cancer Cells: In Vitro Model of Basal Muscle-Invasive Bladder Cancer [ Cancers (Basel), 2024, 16(6)1178]	PubMed: 38539513
IL15RA-STAT3-GPX4/ACSL3 signaling leads to ferroptosis resistance in pancreatic cancer [ Acta Biochim Biophys Sin (Shanghai), 2024, 57(3):389-402]	PubMed: 39396119

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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