Sodium oxamate

製品コードS6871 バッチS687105

化学情報

	Synonyms	SO, oxamate sodium, Aminooxoacetic acid sodium salt, Oxamic acid sodium salt	Storage (From the date of receipt)	3 years -20°C powder
	化学式	C₂H₂NNaO₃
	分子量	111.03	CAS No.	565-73-1
Solubility (25°C)*	体外	Water	22 mg/mL (198.14 mM)
		DMSO	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH‑A. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.
in vitro	Sodium oxamate, a specific inhibitor of LDH-A, enhances the suppressive effects of PARP inhibitors on ovarian cancer without BRCA mutations, remarkably promoting the inhibitory effects of PARP inhibitors on wild-type BRCA ovarian cancer cells.^[3]
in vivo	Sodium oxamate reduces the growth of colorectal cancer in CRC mice, by restoring the down-regulated MMR functional proteins.^[4]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	wild-type BRCA ovarian cancer cells (A2780 and SKOV3)
	濃度	50 nM
	反応時間	24 h
	実験の流れ	Cell proliferation is evaluated using a Cell Counting Kit-8 (CCK-8). SKOV3 cells and A2780 cells are seeded in a 96-well culture plates at a density of 2×10⁵ cells/well and incubated with different concentrations of the drugs (this compound, AG14361) for different times. Detection reagent is added to the cells, and the luminescence signals are determined.
動物実験	動物モデル	four-week-old male BALB/c nude mice of CRC xenograft
	投薬量	500 mg/kg
	投与方法	i.p.

参考

https://pubmed.ncbi.nlm.nih.gov/31180564/
https://pubmed.ncbi.nlm.nih.gov/24064966/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751605/

https://pubmed.ncbi.nlm.nih.gov/34345205/

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Aldehyde Dehydrogenase 2 Lactylation Aggravates Mitochondrial Dysfunction by Disrupting PHB2 Mediated Mitophagy in Acute Kidney Injury [ Adv Sci (Weinh), 2025, 12(8):e2411943]	PubMed: 39737891
A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma [ Cell Rep Med, 2025, 6(8):102292]	PubMed: 40834852
Glycolysis Induces Abnormal Transcription Through Histone Lactylation in T-lineage Acute Lymphoblastic Leukemia [ Genomics Proteomics Bioinformatics, 2025, qzaf029]	PubMed: 40193528
H3K14 lactylation exacerbates neuronal ferroptosis by inhibiting calcium efflux following intracerebral hemorrhagic stroke [ Cell Death Dis, 2025, 16(1):553]	PubMed: 40701963
GDH1-dependent α-ketoglutarate promotes HBV transcription by modulating histone methylations on the cccDNA minichromosome [ Clin Mol Hepatol, 2025, 10.3350/cmh.2024.0694]	PubMed: 39905842
Lactate-HIF-1a axis promotes PINK1-dependent mitophagy to protect porcine granulosa cells against hypoxic stress [ Int J Biol Macromol, 2025, 332(Pt 1):148503]	PubMed: 41138862
Triptolide targets PPP2CA/ITGA5 axis to suppress lactate-driven ovarian cancer progression [ Chin Med, 2025, 20(1):122]	PubMed: 40770810
Protein lactylation within the nucleus independently predicts the prognosis of non‑specific triple‑negative breast cancer [ Oncol Lett, 2025, 29(2):72]	PubMed: 39628828
Class I histone deacetylases catalyze lysine lactylation [ bioRxiv, 2025, 2025.02.25.640220]	PubMed: 40060688
Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization [ Cancer Cell, 2024, S1535-6108(24)00119-3]	PubMed: 38640932

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。