- 阻害剤
- 研究分野別
- PI3K/Akt/mTOR
- Epigenetics
- Methylation
- Immunology & Inflammation
- Protein Tyrosine Kinase
- Angiogenesis
- Apoptosis
- Autophagy
- ER stress & UPR
- JAK/STAT
- MAPK
- Cytoskeletal Signaling
- Cell Cycle
- TGF-beta/Smad
- 化合物ライブラリー
- 抗体
- 新製品
- お問い合わせ
Betaine
別名：trimethylglycine, glycine betaine, lycine, oxyneurine
Betaine (trimethylglycine, glycine betaine, lycine, oxyneurine), a methyl derivative of glycine first isolated from sugar beets, has been shown to have potential benefits for fighting heart disease, improving body composition, and helping promote muscle gain and fat loss because of its abilities to promote protein synthesis in the body.
CAS No. 107-43-7
文献中Selleckの製品使用例（1）
製品安全説明書
現在のバッチを見る：
純度：
100.00%
100.00
Betaine関連製品
生物活性
| 製品説明 | Betaine (trimethylglycine, glycine betaine, lycine, oxyneurine), a methyl derivative of glycine first isolated from sugar beets, has been shown to have potential benefits for fighting heart disease, improving body composition, and helping promote muscle gain and fat loss because of its abilities to promote protein synthesis in the body. |
|---|
| In Vitro | ||||
| In vitro | Betaine shows negligible cytotoxicity even after long-term exposure of cells. It is rich in abundant microorganisms, plants, and animals. In human serum, the resting concentration of betaine ranges from ~2.3 to 8.2 mg/L. As a well-known osmoprotectant, betaine is able to protect cells against osmotically induced inactivation. Betaine could work as a nontoxic CPA (Cryoprotectants) and enable cells to survive ultrarapid cryopreservation to achieve superior cell survival efficiency. It is found that cellular uptake of betaine is ultra-rapid for intracellular protection during the freezing process[1]. Betaine stabilizes corneal epithelial cell volume under hyperosmotic stress and limits hyperosmotic stress-induced HCLE apoptosis[3]. | |||
|---|---|---|---|---|
| 細胞実験 | 細胞株 | Human corneal limbal epithelial (HCLE) cells | ||
| 濃度 | 5 or 10 mM | |||
| 反応時間 | 16 h | |||
| 実験の流れ | Human corneal limbal epithelial (HCLE) cells exposed to culture medium for 16 h at 300 mOsm (isotonic) or 500 mOsm (hyperosmotic) in the presence or absence of betaine (5 or 10 mM) are evaluated for cell volume changes; cell viability; and apoptosis. | |||
| In Vivo | ||
| In Vivo | Betaine (glycine betaine or trimethylglycine) plays important roles as an osmolyte and a methyl donor in animals. In humans, betaine is obtained from the diet or from its metabolic precursor choline. Betaine is utilized as a methyl donor in a reaction that converts homocysteine into methionine via betaine-homocysteine methyltransferase. Betaine also plays a role in osmotic regulation in the kidneys, which are routinely exposed to high extracellular osmolarity during normal operation of the urinary concentrating mechanism. Furthermore, dietary betaine suppresses the activation of nuclear factor-κB (NF-κB) with oxidative stress, and the protein expression of proinflammatory molecules such as cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and tumor necrosis factor (TNF)-α in aged rat kidneys. Betaine has protective effects against LPS-induced memory impairment that are mediated through unique mechanisms involving betaine actions on GAT2, which is involved in the development of memory impairment, without affecting proinflammatory molecules or glial markers[2]. | |
|---|---|---|
| 動物実験 | 動物モデル | Male ddY strain mice |
| 投与量 | 0.081, 0.163, or 0.326 mmol/kg | |
| 投与経路 | s.c. | |
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT05690724 | Recruiting | Mild Cognitive Impairment |
Mitocholine Ltd|Atlantia Food Clinical Trials |
January 9 2023 | Not Applicable |
| NCT05242224 | Recruiting | Growth Disorders|Malnutrition Fetal|Stunting|Development; Delayed Malnutrition|Nutrition Disorder Fetal|Maternal Nutritional Disorders Affecting Fetus or Newborn |
Washington University School of Medicine|St. Louis Children''s Hospital|St. Louis University|Children''s Discovery Institute|Universidad San Francisco de Quito |
January 5 2022 | Not Applicable |
| NCT05073523 | Completed | Healthy |
Chalmers University of Technology |
September 27 2021 | Not Applicable |
| NCT05790070 | Completed | Blood Flow Restriction Training|Betaine Supplementation |
Baylor University |
February 1 2021 | Not Applicable |
化学情報
| 分子量 | 117.15 | 化学式 | C5H11NO2 |
| CAS No. | 107-43-7 | SDF | Download Betaine SDFをダウンロードする Download Betaine SDFをダウンロードする |
| Smiles | C[N+](C)(C)CC(=O)[O-] | ||
| 保管 | |||
|
In vitro |
Water : 23 mg/mL Ethanol : 23 mg/mL DMSO : 6 mg/mL ( (51.21 mM)； 吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。) |
モル濃度計算器 |
|
in vivo Add solvents to the product individually and in order. |
投与溶液組成計算機 | ||||
実験計算
投与溶液組成計算機(クリア溶液)
ステップ１：実験データを入力してください。（実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します）
mg/kg
g
μL
匹
ステップ２：投与溶媒の組成を入力してください。（ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
計算結果：
投与溶媒濃度： mg/ml;
DMSOストック溶液調製方法： mg 試薬を μL DMSOに溶解する（濃度 mg/mL, 注：濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。 )
投与溶媒調製方法：Take μL DMSOストック溶液に μL PEG300，を加え、完全溶解後μL Tween 80，を加えて完全溶解させた後 μL ddH2O，を加え完全に溶解させます。
投与溶媒調製方法：μL DMSOストック溶液に μL Corn oil，を加え、完全溶解。
注意：１.ストック溶液に沈殿、混濁などがないことをご確認ください；
２.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。
技術サポート
ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。
他に質問がある場合は、お気軽にお問い合わせください。
* 必須
Tags: Betaineを買う | Betaine ic50 | Betaine供給者 | Betaineを購入する | Betaine費用 | Betaine生産者 | オーダーBetaine | Betaine化学構造 | Betaine分子量 | Betaine代理店
納期 国内在庫品：受注日の翌日（15時までの受注分） ＊北海道、九州、沖縄への配送は受注日より２日以上 を要する場合あり 海外在庫品：受注後１〜２週間