HSP90α Selective 阻害剤

製品コード 製品名 製品説明 Selective / Pan IC50 / Ki
S7340 CH5138303 CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM. Selective HSP90α, Kd: 0.48 nM
S7097 HSP990 (NVP-HSP990) NVP-HSP990 (HSP990) is a novel, potent and selective HSP90 inhibitor for HSP90α/β with IC50 of 0.6 nM/0.8 nM. Pan HSP90α, IC50: 0.6 nM
S1069 Luminespib (AUY-922, NVP-AUY922) Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2. Pan HSP90α, IC50: 13 nM
S2639 SNX-2112 (PF-04928473) SNX-2112 (PF-04928473) selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG. Pan HSP90α, Ka: 30 nM
Tags: HSP90α inhibitor | HSP90α cancer | HSP90α activity | HSP90α phosphorylation | HSP90α mutation