HSP90β Selective 阻害剤

製品コード 製品名 製品説明 Selective / Pan IC50 / Ki
S7459 VER-50589 VER-50589 is a potent HSP90 inhibitor with IC50 of 21 nM for HSP90β. Selective HSP90β, IC50: 21 nM
S7458 VER-49009 VER-49009 is a potent HSP90 inhibitor with IC50 of 47 nM for HSP90β. Selective HSP90β, IC50: 47 nM
S1498 NVP-BEP800 NVP-BEP800 is a novel, fully synthetic HSP90β inhibitor with IC50 of 58 nM, exhibits>70-fold selectivity against Hsp90 family members Grp94 and Trap-1. Selective HSP90β, IC50: 58 nM
S7097 HSP990 (NVP-HSP990) NVP-HSP990 (HSP990) is a novel, potent and selective HSP90 inhibitor for HSP90α/β with IC50 of 0.6 nM/0.8 nM. Pan HSP90β, IC50: 0.8 nM
S1069 Luminespib (AUY-922, NVP-AUY922) Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2. Pan HSP90β, IC50: 21 nM
S2639 SNX-2112 (PF-04928473) SNX-2112 (PF-04928473) selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG. Pan HSP90β, Ka: 30 nM
Tags: HSP90β inhibitor | HSP90β cancer | HSP90β activity | HSP90β phosphorylation | HSP90β mutation
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