||Selective / Pan
||IC50 / Ki
||LY411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch clevage with IC50 of 0.39 nM.
||γ secretase (cell-based), IC50: 0.082 nM; γ secretase (membrane-based), IC50: 0.078 nM
||YO-01027 (Dibenzazepine) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM for APPL and Notch cleavage, respectively.
||γ secretase(APPL), IC50: 2.6 nM
||RO4929097 is a γ secretase inhibitor with IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. Phase 2.
||γ secretase, IC50: 4 nM
Tags: γ-Secretase mutation | γ-Secretase cancer | γ-Secretase signaling pathway | γ-Secretase inhibitor | Gamma secretase inhibitor | γ-Secretase phosphorylation