(20S)-Protopanaxatriol

製品コードS3617 バッチS361701

化学情報

	Synonyms	g-PPT, 20(S)-APPT	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₃₀H₅₂O₄
	分子量	476.73	CAS No.	34080-08-5
Solubility (25°C)*	体外	DMSO	95 mg/mL (199.27 mM)
		Ethanol	95 mg/mL (199.27 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	(20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER).
in vitro	Protopanaxtriol (Ppt) is a neuroprotective ginseng extract. Ppt exerts its antioxidative activity via several mechanisms, such as direct scavenging of free radicals and restoration of succinate dehydrogenase activity. These mechanisms may contribute to its potent antioxidative and putative neuroprotective activities^[1]. Ppt exhibited strong noncompetitive inhibition towards UGT1A1 and competitive inhibition towards UGT2B7. The inhibition kinetic parameters (Ki) were calculated to be 8.8 and 2.2 μM for UGT1A1 and UGT2B7, respectively^[2]. PPT could repress the viability and invasiveness, and promote the apoptosis in A549 and SK-MES-1 cells.
in vivo	Protopanaxtriol (Ppt) is shown to reduce learning and memory impairment associated with Alzheimer's diseases and protect against 3-NP-induced oxidative stressin the rat model of Huntington's disease, which is associated with its anti-oxidant activity. Ppt prevents short- and long-term memory impairments induced by chronic sleep deprivation probably through antagonizing oxidative stress in the cortex and hippocampus^[1].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	A549 cells or SK-MES-1 cells
	濃度	0, 0.4, 4 or 40 uM
	反応時間	48 h
	実験の流れ	A549 cells or SK-MES-1 cells are seeded in 96-well plates (3×10³ cells/well), and then treated with different concentration of PPD, PPT, G-Rg3 or G-Rh2 (0, 0.4, 4 or 40 μM) for 48 h, with cisplatin (2 ug/ml) as a positive control and 0.1% DMSO as a blank control. Then these cells are collected and detected the viability by the cell-counting Kit-8 (CCK-8) assay.
動物実験	動物モデル	ICR male mice
	投薬量	20μmol/kg, 40μmol/kg
	投与方法	i.p.

参考

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。