Selleck製品は、NatureやScience等の権威ある科学雑誌に掲載された論文中で数多く使用されています。

新製品

製品コード 製品名 Target Pathway 製品説明
S8795 FDL169 CFTR Transmembrane Transporters FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein.
S8341 TAK-243 (MLN7243) E1 Activating Ubiquitin TAK-243 (MLN7243) is a potent, mechanism-based small-molecule inhibitor of the ubiquitin activating enzyme (UAE) with an IC50 of 1 ± 0.2 nM in the UBCH10 E2 thioester assay. It has minimal inhibitory activity in a panel of kinase and receptor assays, as well as on human carbonic anhydrase type I and type II.
S8821 GSK3179106 c-RET Apoptosis GSK3179106 is a potent, selective, and gut-restricted pyridone hinge binder small molecule RET kinase inhibitor with a RET IC50 of 0.3 nM and is efficacious in vivo.
S8793 ULK-101 Autophagy Autophagy ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively.
S8804 PF-06700841 JAK JAK/STAT PF-06700841 is a potent inhibitor of Tyk2 and Jak1 with IC50s of 23 nM, 17 nM, 77 nM for Tyk2, Jak1 and Jak2 respectively. It has appropriate in-family selectivity against JAK2 and JAK3.
S8788 CH7057288 Trk receptor Protein Tyrosine Kinase CH7057288 is a potent and selective TRK inhibitor with IC50 values of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB, and TRKC respectively.
S8636 Selitrectinib(LOXO-195) Trk receptor Protein Tyrosine Kinase Selitrectinib(LOXO-195) is an orally available, highly potent, and selective TRK kinase inhibitor with low nanomolar inhibitory activity against TRKA G595R, TRKC G623R, and TRKA G667C, IC50s ranging from 2.0 to 9.8 nmol/L. It is more than 1,000-fold selective for 98% of non-TRK kinases tested.
S8739 PLX51107 Epigenetic Reader Domain Epigenetics PLX51107 is as a novel BET inhibitor with modest preference for bromodomain-1 (BD1) versus bromodomain-2 (BD2) within each BET protein (Kd = 1.6, 2.1, 1.7, and 5 nM for BD1 and 5.9, 6.2, 6.1 and 120 nM for BD2 of BRD2, BRD3, BRD4, and BRDT, respectively. Among non-BET proteins, PLX51107 shows significant interactions only with the bromodomains of CBP and EP300 (p300) (Kd in the 100 nM range).