Nature, 2016, 537(7620):422-427.
Nature, 2015,520(7547):368-72.

FRA1 downregulation during RAFi treatment drives the reactive secretome.
c, In A375 cells treated in vitro with vehicle or vemurafenib for 6 or 48 h. Relative mRNA levels of FRA1 during vemurafenib exposure [0.1-1 uM]. d, Representative immunofluorescence staining of A375/A375R tumours for GFP (A375R, green) and FRA1 (red) after vehicle or vemurafenib treatment (5 days). DAPI, 4',6-diamidino-2-phenylindole. Scale bars, 50 um.

Signaling Pathway