ホームページinvivo抗体

invivo抗体

製品コード 製品名 Application Product Validations 製品説明
A2115 Anti-mouse PD-L1 (B7-H1)-InVivo [10F.9G2] in vivo PD-L1 blockade,IHC (frozen),FCM A2115-Anti-mouse-PD-L1(B7-H1)-InVivo.gif Anti-mouse PD-L1 (B7-H1)-InVivo [10F.9G2] monoclonal antibody reacts with mouse PD-L1 (also known as B7-H1, CD274). Anti-mouse PD-L1 (B7-H1)-InVivo [10F.9G2] has been shown to block the interaction between PD-L1 and PD-1 and between PD-L1 and B7-1 (CD80).
A2122 Anti-mouse PD-1 (CD279)-InVivo [RMP1-14] in vivo blocking of PD-1/PD-L signaling A2122-Anti-mouse PD-1 (CD279)-InVivo.gif Anti-mouse PD-1 (CD279)-InVivo [RMP1-14] reacts with mouse PD-1 (programmed death-1) also known as CD279. PD-1 is a 50-55 kDa cell surface receptor encoded by the Pdcd1 gene that belongs to the CD28 family of the Ig superfamily.
A2102 Anti-mouse CD8α-InVivo [2.43] In vivo CD8+ T cell depletion,WB A2102-Anti-mouse-CD8alpha-InVivo-6.gif Anti-mouse CD8α-InVivo [2.43] reacts with mouse CD8α. CD8 is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). It binds to class I MHC molecules displayed by antigen presenting cells (APC).
A2111 Anti-human CD3-InVivo [OKT-3] in vitro T cell stimulation/activation, FCM Anti-human CD3-InVivo [OKT-3] reacts with human CD3ε which is a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily.Anti-human CD3-InVivo [OKT-3] has immunosuppressive properties in vivo and has been shown to effectively treat renal, heart and liver allograft rejection.
A2101 Anti-mouse CD4-InVivo [GK1.5] In vivo CD4+ T cell depletion,FCM,WB A2101 Anti-mouse CD4-InVivo-1.gif Anti-mouse CD4-InVivo [GK1.5] reacts with mouse CD4, which is a 55 kDa cell surface type I membrane glycoprotein. CD4 is a co-receptor of the T cell receptor (TCR) and assists the latter in communicating with antigen-presenting cells.
A2116 Rat IgG2b isotype control-InVivo [LTF-2] A2116-Rat IgG2b isotype control-InVivo.gif Rat IgG2b isotype control-InVivo [LTF-2] reacts with keyhole limpet hemocyanin (KLH). Because KLH is not expressed by mammals this antibody is ideal for use as an isotype-matched control for rat IgG2b antibodies in most in vivo and in vitro applications.
A2110 Anti-mouse CD16/CD32-InVivo [2.4G2] in vitro/vivo Fc receptor blocking A2110 Anti-mouse CD16CD32-InVivo.gif Anti-mouse CD16/CD32-InVivo [2.4G2] reacts specifically with mouse CD16 (FcγRIII) and CD32 (FcγRII). It has also been reported to react non-specifically via its Fc domain to FcγRI. Anti-mouse CD16/CD32-InVivo [2.4G2] is commonly used in flow cytometry staining experiments to prevent non-specific binding of IgG to the FcγIII and FcγII, and possibly FcγI, receptors prior to staining with antigen specific primary antibodies. For Fc receptor blocking of mouse samples in flow cytometry experiments, add 0.25 μg of anti-mouse CD16/32 antibody per 10^6 cells in a total reaction volume of 100 μL.
A2103 Anti-mouse CTLA-4 (CD152)-InVivo [9H10] in vivo/vitro CTLA-4 neutralization, FCM,WB Anti-mouse CTLA-4 (CD152)-InVivo [9H10] reacts with mouse CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152. Anti-mouse CTLA-4 (CD152)-InVivo [9H10] has been shown to promote T cell co-stimulation by blocking CTLA-4 binding to the B7 co-receptors, allowing for CD28 binding.
A2120 Anti-mouse IL-17A-InVivo [17F3] in vivo IL-17A neutralization A2120-Anti-mouse IL-17A-InVivo-1.gif Anti-mouse IL-17A-InVivo [17F3] reacts with mouse IL-17A which is a 15-20 kDa cytokine expressed by Th17 cells, γδ T cells, iNKT cells, NK cells, LTi cells, neutrophils, and intestinal Paneth cells. Anti-mouse IL-17A-InVivo [17F3] has been shown to neutralize IL-17A in vivo.
A2113 Anti-human/mouse TGF-β-InVivo [1D11.16.8] in vivo/vitro TGFβ neutralization,WB Anti-human/mouse TGF-β-InVivo [1D11.16.8] reacts with mouse, human, rat, monkey, hamster, canine and bovine TGF-β (transforming growth factor beta) isoforms 1, 2 and 3.The 1D11.16.8 monoclonal antibody is a neutralizing antibody.
A2121 Anti-mouse IFNAR-1-InVivo [MAR1-5A3] in vivo IFNAR-1 blockade, in vitro IFNAR-1 blockade, WB A2121 Anti-mouse IFNAR-2-InVivo.gif Anti-mouse IFNAR-1-InVivo [MAR1-5A3] reacts with mouse IFNAR-1 (IFN alpha/beta receptor subunit 1). Anti-mouse IFNAR-1-InVivo [MAR1-5A3] has been shown to inhibit Type I IFN receptor signaling in vitro and in vivo.
A2117 Mouse IgG2a isotype control-InVivo [C1.18.4] Mouse IgG2a isotype control-InVivo [C1.18.4] is ideal for use as a non-reactive isotype-matched control for mouse IgG2a antibodies in most in vivo and in vitro applications.
A2104 Anti-mouse CD3ε-InVivo [145-2C11] in vitro T cell stimulation/activation, IF, FCM, WB Anti-mouse CD3ε-InVivo [145-2C11] reacts with mouse CD3ε which is a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily. Anti-mouse CD3ε-InVivo [145-2C11] has been shown to induce T lymphocyte activation, proliferation, and apoptosis in vitro via binding and stimulating the TCR. When used in vivo the antibody is reported to produce T cell activation, anergy, or death.
A2118 Anti-mouse IL-6-InVivo [MP5-20F3] in vivo IL-6 neutralization A2118 Anti-mouse IL-6-InVivo.gif Anti-mouse IL-6-InVivo [MP5-20F3] can reacts with mouse IL-6 (interleukin-6) which is a 21-28 kDa cytokine that is expressed by many cell types, including T lymphocytes, B lymphocytes, monocytes, fibroblasts, and endothelial cells. Anti-mouse IL-6-InVivo has been shown to neutralize the bioactivity of natural or recombinant IL-6.
A2108New Anti-mouse CD28-InVivo [PV-1] in vitro T cell stimulation/activation Anti-mouse CD28-InVivo [PV-1] reacts with mouse CD28.Anti-mouse CD28-InVivo [PV-1] has been shown to stimulate the proliferation and cytokine production by activated T and NK cells.
A2119 Rat IgG1 isotype control-InVivo [HRPN] A2119-Rat-IgG1-isotype-control.gif Rat IgG1 isotype control-InVivo [HRPN] reacts with horseradish peroxidase (HRP). Because HRP is not expressed by mammals this antibody is ideal for use as an isotype-matched control for rat IgG1 antibodies in most in vivo and in vitro applications.
A2105 Anti-mouse IFNγ-InVivo [R4-6A2] in vivo/vitro IFNγ neutralization A2105-Anti-mouse-IFN-Gamma-InVivo-1.gif Anti-mouse IFNγ-InVivo [R4-6A2] reacts with mouse IFNγ (interferon gamma) which is a 20 kDa soluble pleiotropic cytokine and the sole member of the type II class of interferons. Anti-mouse IFNγ-InVivo [R4-6A2] has been shown to neutralize both natural and recombinant IFNγ.
A2109 Anti-mouse IL-4-InVivo [11B11] in vivo/vitro IL-4 neutralization,FCM,WB Anti-mouse IL-4-InVivo [11B11] reacts with mouse IL-4 (interleukin-4) which is a multifunctional 14 kDa cytokine.Anti-mouse IL-4-InVivo [11B11] has been shown to neutralize the bioactivity of natural or recombinant IL-4.
A2149 Anti-mouse CD19-InVivo [1D3] Anti-mouse CD19-InVivo A2149-Anti-mouse-CD19-InVivo.gif Anti-mouse CD19-InVivo [1D3] reacts with mouse CD19, a B cell-specific 95 kDa transmembrane glycoprotein of the immunoglobulin superfamily.
A2159 Anti-mouse CSF1R (CD115)-InVivo [AFS98] A2159-Anti-mouse-CSF1R-CD115-InVivo-2.gif Anti-mouse CSF1R (CD115)-InVivo [AFS98] reacts with mouse colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115. CSF1R is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family.
A2114 Anti-mouse NK1.1-InVivo [PK136] in vivo NK cell depletion,FCM A2114-Anti-mouse-NK1-1-InVivo.gif Anti-mouse NK1.1-InVivo [PK136] reacts with mouse NK1.1 also known as CD161b/CD161c, KLRB1, NKR-P1A and Ly-55.
A2107 Anti-mouse CD25 (IL-2Rα)-InVivo [PC-61.5.3] in vivo regulatory T cell depletion,FCM A2107-anti-mouse CD25 (IL-2Ralpha)-InVivo.gif Anti-mouse CD25 (IL-2Rα)-InVivo [PC-61.5.3] reacts with mouse IL-2Rα also known as CD25, Ly-43, p55, or Tac.The PC-61.5.3 antibody has been shown to inhibit the binding of IL-2 to both the low and high affinity IL-2 receptor forms. Additionally, Anti-mouse CD25 (IL-2Rα)-InVivo [PC-61.5.3] is commonly used to deplete CD4+FoxP3+ T regulatory cells in vivo.
A2141 Anti-mouse Ter-119-InVivo [TER-119] Anti-mouse Ter-119-InVivo Anti-mouse Ter-119-InVivo [TER-119] reacts with mouse Ter-119, a 52 kDa glycophorin A-associated protein that is expressed by erythroid cells from the early proerythroblast stage to mature erythrocytes. Anti-mouse Ter-119-InVivo [TER-119] is commonly used for identifying erythrocytes and cells in the erythroid lineage.
A2168 Anti-human CD3 (UCHT1)-InVivo [UCHT1] Anti-human CD3 (UCHT1)-InVivo [UCHT1] reacts with human CD3ε a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily
A2180New Anti-Mouse δ-like protein 1 (DLL1)-Invivo [HMD1-5] in vivo DLL1 neutralization Anti-Mouse δ-like protein 1 (DLL1)-Invivo [HMD1-5] reacts with mouse δ-like protein 1 (DLL1) one of many Notch ligands. DLL1 is expressed by thymic and splenic stromal cells, macrophages, and dendritic cells.
A2142 Anti-mouse/rat IL-1β-InVivo [B122] Anti-mouse/rat IL-1β-InVivo Anti-mouse/rat IL-1β-InVivo [B122] reacts with precursor and mature secreted forms of mouse and rat IL-1β a 17 kDa pro-inflammatory cytokine produced primarily by monocytes.
A2181New Anti-mouse GITR-Invivo [DTA-1] in vivo GITR stimulation Anti-Mouse GITR-Invivo [DTA-1] reacts with mouse GITR (glucocorticoid-induced TNFR-related gene), a 66-70 kDa co-stimulatory immune checkpoint molecule belonging to the Tumor Necrosis Factor superfamily (TNFRSF18). Anti-Mouse GITR-Invivo [DTA-1] is an agonistic antibody that is commonly used to induce GITR signaling in vivo.
A2143 Anti-mouse 4-1BB (CD137)-InVivo [3H3] Anti-mouse 4-1BB (CD137)-InVivo Anti-mouse 4-1BB (CD137)-InVivo [3H3] reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137.
A2182New Anti-mouse/human CD11b-Invivo [M1/70] in vivo CD11b neutralization; ILC2 cell purification, Flow cytometry Anti-mouse/human CD11b-Invivo [M1/70] reacts with mouse and human CD11b, a 170 kDa membrane glycoprotein also known as integrin alpha M (ITGAM). CD11b belongs to the integrin alpha family and is primarily expressed on granulocytes and monocytes/macrophages but also expressed on dendritic cells, NK cells, and subsets of T and B cells.
A2144 Anti-mouse TIGIT-InVivo [1G9] Anti-mouse TIGIT-InVivo Anti-mouse TIGIT-InVivo [1G9] reacts with mouse TIGIT (T cell immunoreceptor with Ig and ITIM domains). TIGIT is a 26 kDa, type I transmembrane protein and a member of the poliovirus receptor (PVR) family.
A2183New Anti-mouse IL-7Rα (CD127)-Invivo [A7R34] in vivo blocking of IL-7Rα signaling, Flow cytometry Anti-mouse IL-7Rα (CD127)-Invivo [A7R34] reacts with mouse IL-7Rα also known as CD127. IL-7Rα is a 60-90 kDa type I transmembrane glycoprotein expressed on immature B cells, thymocytes, peripheral T cells, and bone marrow stromal cells.
A2145 Mouse IgG2b isotype control-InVivo [MPC-11] Mouse IgG2b isotype control-InVivo Mouse IgG2b isotype control-InVivo [MPC-11] is ideal for use as a non-reactive isotype-matched control for mouse IgG2b antibodies in most in vivo and in vitro applications.
A2165 Anti-mouse PD-1 (CD279)(29F.1A12)-InVivo [29F.1A12] in vivo blocking of PD-1/PD-L signaling in vitro PD-1 neutralization Anti-mouse PD-1 (CD279)(29F.1A12)-InVivo [29F.1A12] reacts with mouse PD-1 (programmed death-1) also known as CD279. PD-1 is a 50-55 kDa cell surface receptor encoded by the Pdcd1 gene that belongs to the CD28 family of the Ig superfamily.
A2146 Anti-LCMV nucleoprotein-InVivo [VL-4] Anti-LCMV nucleoprotein-InVivo Anti-LCMV nucleoprotein-InVivo [VL-4] reacts with lymphocytic choriomeningitis virus (LCMV) nucleoprotein (NP), a 63 kDa structural protein.
A2147 Anti-mouse CXCR3 (CD183)-InVivo [CXCR3-173] Anti-mouse CXCR3 (CD183)-InVivo Anti-mouse CXCR3 (CD183)-InVivo [CXCR3-173] reacts with mouse CXCR3 also known as CD183, a 38 kDa chemokine receptor for CXCL9 (MIG), CXCL10 (IP-10), and CXCL11 (ITAC).
A2148 Anti-mouse GM-CSF-InVivo [MP1-22E9] Anti-mouse GM-CSF-InVivo Anti-mouse GM-CSF-InVivo [MP1-22E9] reacts with mouse granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony stimulating factor 2 (CSF2).
A2150 Armenian hamster IgG isotype control-InVivo [PIP] Armenian hamster IgG-InVivo Armenian hamster IgG isotype control-InVivo [PIP] is ideal for use as an isotype control for Armenian hamster IgG antibodies in most in vivo and in vitro applications.
A2151 Anti-mouse IL-10R (CD210)-InVivo [1B1.3A] Anti-mouse IL-10R (CD210)-InVivo A2151-Anti-mouse-IL-10R.gif Anti-mouse IL-10R (CD210)-InVivo [1B1.3A] reacts with mouse IL-10R (IL-10 receptor) also known as CD210. The IL-10R is a class II cytokine receptor and is expressed by a variety of cell types including thymocytes, T lymphocytes, B lymphocytes, NK cells, monocytes, and macrophages.
A2184New Anti-mouse CD54 (ICAM-1)-Invivo [YN1/1.7.4] in vivo ICAM-1 neutralization, Immunohistochemistry (frozen), ELISA Anti-mouse CD54 (ICAM-1)-Invivo [YN1/1.7.4] reacts with mouse CD54 also known as Intercellular Adhesion Molecule-1 (ICAM-1). CD54 is a 90 kDa single-chain transmembrane glycoprotein and a member of the Ig superfamily.
A2152 Anti-mouse IFNγ (XMG1.2)-InVivo [XMG1.2] Anti-mouse IFNγ (XMG1.2)-InVivo Anti-mouse IFNγ (XMG1.2)-InVivo [XMG1.2] reacts with mouse IFNγ (interferon gamma) a 20 kDa soluble pleiotropic cytokine and the sole member of the type II class of interferons.
A2185New Anti-human/monkey CD28-Invivo [CD28.2] in vitro T cell stimulation/activation, Immunoprecipitation, Flow cytometry, Immunohistochemistry (frozen) Anti-human/monkey CD28-Invivo [CD28.2] reacts with human and monkey CD28, a 45 kDa costimulatory receptor and a member of the Ig superfamily. CD28 is expressed by thymocytes, most peripheral T cells, and NK cells.
A2153 Anti-mouse IL-2 (S4B6-1)-InVivo [S4B6-1] Anti-mouse IL-2 (S4B6-1)-InVivo Anti-mouse IL-2 (S4B6-1)-InVivo [S4B6-1] reacts with mouse IL-2, a 17 kDa cytokine that is mainly produced by T cells in response to antigenic or mitogenic stimulation.
A2154 Anti-mouse CD86 (B7-2)-InVivo [GL-1] Anti-mouse CD86 (B7-2)-InVivo Anti-mouse CD86 (B7-2)-InVivo [GL-1] reacts with mouse CD86 also known as B7-2. CD86 is an 80 kDa Ig superfamily member.
A2156 Anti-human PD-L1 (B7-H1)-InVivo [29E.2A3] Anti-human PD-L1 (B7-H1)-InVivo Anti-human PD-L1 (B7-H1)-InVivo [29E.2A3] reacts with human PD-L1 (programmed death ligand 1) also known as B7-H1 or CD274. PD-L1 is a 40 kDa type I transmembrane protein that belongs to the B7 family of the Ig superfamily.
A2157 Anti-mouse IL-6R-InVivo [15A7] Anti-mouse IL-6R-InVivo Anti-mouse IL-6R-InVivo [15A7] reacts with the mouse IL-6 receptor α chain also known as CD126. CD126 is an 80 kDa type I cytokine receptor and a member of the immunoglobulin superfamily.
A2186New Anti-mouse CD276 (B7-H3) [MJ18] in vivo B7-H3 blockade, Flow cytometry Anti-mouse CD276 (B7-H3) [MJ18] reacts with mouse CD276 also known as B7-H3. CD276 is a type I transmembrane protein and a member of the B7 family of co-stimulatory proteins.
A2187New Anti-mouse CD73 [TY/23] in vivo CD73 blockade, in vitro CD73 blockade Anti-mouse CD73 [TY/23] reacts with mouse CD73 also known as ecto-5′-nucleotidase (5′-NT), a 69 kDa GPI-anchored cell-surface protein. In mice, expression of CD73 is restricted to CD11b+ myeloid cells in the bone marrow and T cells in the spleen.
A2188New Anti-mouse IL-9 [9C1] in vivo IL-9 neutralization Anti-mouse IL-9 [9C1] reacts with mouse IL-9, a pleiotropic cytokine expressed by Th9 cells, Th2 cells, Th17 cells, regulatory T cells, NKT cells, ILC2s, and mast cells.
A2158 Anti-mouse Ly6G-InVivo [1A8] Anti-mouse Ly6G-InVivo A2158-Anti-mouse-Ly6G-InVivo.gif Anti-mouse Ly6G-InVivo [1A8] reacts with mouse Ly6G. Ly6G is a 21-25 kDa member of the Ly-6 superfamily of GPI-anchored cell surface proteins with roles in cell signaling and cell adhesion.
A2126 Anti-mouse VEGFR-2-InVivo [DC101] Anti-mouse VEGFR-2-InVivo Anti-mouse VEGFR-2-InVivo [DC101] reacts with mouse VEGFR-2 (vascular endothelial growth factor receptor 2) also known as CD309, KDR, and Flk-1 and inhibit VEGFR-2 signaling in vivo. VEGFR-2 plays a key role in vascular development and permeability.
A2127 Anti-human CD28-InVivo [9.3] Anti-human CD28-InVivo Anti-human CD28-InVivo [9.3] reacts with human CD28, a 45 kDa costimulatory receptor and a member of the Ig superfamily. It stimulate the proliferation of human T cells in vitro.
A2129 Anti-mouse Thy1.2 (CD90.2)-InVivo [30H12] Anti-mouse Thy1.2 (CD90.2)-InVivo Anti-mouse Thy1.2 (CD90.2)-InVivo [30H12] is a monoclonal antibody reacts with mouse Thy1.2 also known as CD90.2. It induces Ca2+ flux in thymocytes and is particularly useful for depleting T lymphocytes.
A2130 Anti-mouse LFA-1α (CD11a)-InVivo [M17/4] Anti-mouse LFA-1α (CD11a)-InVivo Anti-mouse LFA-1α (CD11a)-InVivo [M17/4] is a monoclonal antibody reacts with mouse LFA-1α (lymphocyte function-associated antigen 1 alpha) also known as integrin alpha L chain and CD11a. It plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50), and also functions in lymphocyte costimulatory signaling.
A2131 Anti-mouse TIM-3 (CD366)-InVivo [B8.2C12] Anti-mouse TIM-3 (CD366)-InVivo Anti-mouse TIM-3 (CD366)-InVivo [B8.2C12] reacts with mouse TIM-3 (T cell immunoglobulin and mucin domain-3) also known as CD366. TIM-3 is specifically expressed at high levels on the surface of Th1 lymphocytes. Anti-mouse TIM-3 (CD366)-InVivo [B8.2C12] binds to the BALB/c allele of TIM-3 while reactivity to the C57Bl/6 allele. Inhibition of TIM-3 signaling in mice exacerbates experimental autoimmune encephalomyelitis and promotes IFNγ production and Th1 cell proliferation.
A2132 Anti-mouse/human/rat CCL2 (MCP-1)-InVivo [2H5] in vivo CCL2 neutralization, Immunohistochemistry (frozen) Anti-mouse/human/rat CCL2 (MCP-1)-InVivo [2H5] reacts with mouse, human, and rat CCL2, also known as monocyte chemoattractant protein 1 (MCP-1). MCP-1 is a 13 kDa chemokine produced mainly by monocytes/macrophages and is a potent monocyte-attracting chemokine. Anti-mouse/human/rat CCL2 (MCP-1)-InVivo [2H5] has been shown to neutralize the biological effects of CCL2 in vivo.
A2133 Anti-mouse LAG-3-InVivo [C9B7W] in vitro &in vivo LAG-3 neutralization, Flow cytometry, Western blot A2133-Anti-mouse-LAG-3-InVivo.gif Anti-mouse LAG-3-InVivo [C9B7W] reacts with mouse LAG-3 also known as CD223. LAG-3 promotes immune responses by activating antigen-presenting cells. Anti-mouse LAG-3-InVivo [C9B7W] has been reported to block the function of murine LAG-3 in vivo and in vitro.
A2134 Anti-mouse IL-18-InVivo [YIGIF74-1G7] in vitro &in vivo IL-18 neutralization Anti-mouse IL-18-InVivo [YIGIF74-1G7] reacts with mouse IL-18. IL-18 an 18 kDa pro-inflammatory cytokine is expressed by activated macrophages, keratinocytes, Kupffer cells, intestinal epithelial cells, and osteoblasts.
A2135 Anti-mouse Ly6G/Ly6C (Gr-1)-InVivo [RB6-8C5] in vivo depletion of Gr-1+ myeloid cells, Flow cytometry, Immunohistochemistry (paraffin), Immunohistochemistry (frozen) Anti-mouse Ly6G/Ly6C (Gr-1)-InVivo [RB6-8C5] reacts strongly with mouse Ly6G and weakly with mouse Ly6C previously referred to as GR-1. Ly6G is a 21-25 kDa member of the Ly-6 superfamily of GPI-anchored cell surface proteins with roles in cell signaling and cell adhesion.
A2173 Anti-mouse L-Selectin (CD62L)-InVivo [Mel-14] in vivo CD62L neutralization. Anti-mouse L-Selectin (CD62L)-InVivo [Mel-14] reacts with mouse CD62L also known as L-selectin and MEL-14. CD62L is a 76 kDa glycoprotein and a member of the selectin family.
A2174 Anti-mouse/human CD44-InVivo [IM7] in vivo/vitro CD44 neutralization. Anti-mouse/human CD44-InVivo [IM7] reacts with human and mouse CD44 also known as Hermes, HCAM, and Pgp-1. CD44 is an 80-95 kDa glycoprotein that is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells.
A2160 Anti-rat Kappa Immunoglobulin Light Chain-InVivo [MAR 18.5] Anti-rat Kappa Immunoglobulin Light Chain-InVivo Anti-rat Kappa Immunoglobulin Light Chain-InVivo [MAR 18.5] reacts with the kappa chain of the rat immunoglobulin light chain. The κ chain is one of two types of polypeptide subunits which make up the immunoglobulin light chain.
A2161 Anti-mouse ICOSL (CD275)-InVivo [HK5.3] Anti-mouse ICOSL (CD275)-InVivo Anti-mouse ICOSL (CD275)-InVivo [HK5.3] reacts with mouse ICOSL (inducible T cell co-stimulator ligand) also known as CD275, B7RP-1, and B7-H2. ICOSL is a 40 kDa immune checkpoint protein belonging to the Ig receptor superfamily.
A2162 Anti-mouse/human VLA-4 (CD49d)-InVivo [PS/2] Anti-mouse/human VLA-4 (CD49d)-InVivo Anti-mouse/human VLA-4 (CD49d)-InVivo [PS/2] reacts with human and mouse VLA-4 α chain also known as CD49d and integrin alpha 4. VLA-4 is a 150 kDa glycoprotein belonging to the integrin family that is expressed by many cell types including T and B lymphocytes, monocytes, eosinophils, basophils, mast cells, thymocytes, NK cells, and dendritic cells.
A2166 Anti-mouse CD28(37.51)-InVivo [37.51] Anti-mouse CD28(37.51)-InVivo Anti-mouse CD28(37.51)-InVivo [37.51] reacts with mouse CD28, a 45 kDa costimulatory receptor and a member of the Ig superfamily. CD28 is expressed by thymocytes, most peripheral T cells, and NK cells.
A2172 Anti-human MHC Class I (HLA-A, HLA-B, HLA-C)-InVivo [W6/32] Anti-human MHC Class I (HLA-A, HLA-B, HLA-C)-InVivo Anti-human MHC Class I (HLA-A, HLA-B, HLA-C)-InVivo [W6/32] reacts with the human major histocompatibility complex (MHC) class I, HLA-A, B, and C. All human nucleated cell express MHC class I antigens associated with β2-microglobulin. MHC class I plays a central role in cell-mediated immune responses and tumor surveillance.
A2169 Anti-mouse MHC Class II (I-A/I-E)-InVivo [M5/114] Anti-mouse MHC Class II (I-A/I-E)-InVivo Anti-mouse MHC Class II (I-A/I-E)-InVivo [M5/114] reacts with mouse MHC Class II haplotypes I-Ab, I-Ad, I-Aq, I-Ed, and I-Ek. The antibody does not react with I-Af, I-Ak, or I-As haplotypes. The M5/114 antibody is reported to inhibit I-A-restricted T cell responses.
A2170 Anti-mouse CSF1-InVivo [5A1] Anti-mouse CSF1-InVivo Anti-mouse CSF1-InVivo [5A1] reacts with mouse colony stimulating factor 1 (CSF1) also known as macrophage colony-stimulating factor (M-CSF). CSF1 is a hematopoietic growth factor that is expressed by many different cell types including fibroblasts, stromal cells, osteoblasts, activated T cells, macrophages, and B cells.
A2106 Mouse IgG1 isotype control-InVivo [MOPC-21] Mouse IgG1 isotype control-InVivo FCM,IHC,IP,WB The monoclonal mouse IgG1 K immunoglobulin is ideal for use as a non-reactive isotype-matched control for mouse IgG1 antibodies in most in vivo and in vitro applications.
A2123 Rat IgG2a isotype control-InVivo [2A3] Rat IgG2a isotype control-InVivo [2A3] can be used as an isotype-matched control for rat IgG2a antibodies.
A2112 Anti-mouse CD40L (CD154)-InVivo [MR-1] in vivo/vitro blocking of CD40/CD40L,WB Anti-mouse CD40L (CD154)-InVivo [MR-1] reacts with mouse CD154 also known as CD40 ligand. The MR-1 monoclonal antibody has been reported to inhibit in vitro activation of B lymphocytes by blocking the binding of CD154 with CD40 on T helper cells as well as inhibit the formation of germinal centers and disrupt antigen-specific T cell responses. Additionally, the MR-1 antibody blocks interactions of T cells and antigen-presenting cells in vitro and blocks the development of experimental autoimmune disease in vivo.
A2167 Anti-mouse CD3-InVivo [17A2] Anti-mouse CD3-InVivo Anti-mouse CD3-InVivo [17A2] reacts with mouse CD3, a transmembrane cell-surface protein that belongs to the immunoglobulin superfamily.CD3 is expressed on T lymphocytes, NK-T cells, and to varying degrees on developing thymocytes.
A2163 Anti-mouse IL-12 p40-InVivo [C17.8] Anti-mouse IL-12 p40-InVivo Anti-mouse IL-12 p40-InVivo [C17.8] reacts with mouse p40 also known as IL-12β. p40 is a 40 kDa subunit of IL-12 and IL-23. IL-12 is a heterodimeric cytokine composed of subunits IL-12α p35 and IL-12β p40.
A2164 Anti-mouse B220-InVivo [RA3.3A1/6.1] Anti-mouse B220-InVivo Anti-mouse B220-InVivo [RA3.3A1/6.1] reacts with mouse B220 also known as CD45R. B220 is a 220 kDa transmembrane protein tyrosine phosphatase expressed on B cells and some subsets of T and NK cells.
A2179New Anti-Mouse CD41-Invivo [MWReg30] in vivo/vitro CD41 neutralization. Anti-Mouse CD41-Invivo [MWReg30] specifically binds to CD41, which is also known as glycoprotein IIb (gpIIb, GP IIb), Integrin α IIb chain, or Integrin alpha 2b. CD41 is a transmembrane glycoprotein that is encoded by Itga2b. CD41 associates with Integrin β3 chain (gpIIIa or CD61) to form the gpIIb/IIIa (CD41/CD61) complex.
A2124 Anti-mouse TNFα-InVivo [XT3.11] in vitro &in vivo TNFα neutralization, Western blot Anti-mouse TNFα-InVivo [XT3.11] reacts with mouse TNFα (tumor necrosis factor-alpha), a multifunctional proinflammatory cytokine. TNFα dysregulation is been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. TNFα knockout animals display defects in response to bacterial infection, characterized by defects in forming organized follicular dendritic cell networks and germinal centers with a lack of primary B cell follicles.
A2125 Anti-mouse OX40 (CD134)-InVivo [OX-86] in vitro &in vivo OX40 activation, Western blot Anti-mouse OX40 (CD134)-InVivo [OX-86] reacts with mouse OX-40 also known as CD134. OX-40 plays a major role in regulating both CD4 and CD8 T cell clonal expansion. Anti-mouse OX40 (CD134)-InVivo [OX-86] treatment strongly enhances the generation of antigen-specific effector T cells, prevents the induction of T cell tolerance, and delays tumor growth in vivo.
A2171 Anti-mouse PD-L1 (B7-H1) (10F.2H11)-InVivo [10F.2H11] Anti-mouse PD-L1 (B7-H1) (10F.2H11)-InVivo Anti-mouse PD-L1 (B7-H1) (10F.2H11)-InVivo [10F.2H11] reacts with mouse PD-L1 (programmed death ligand 1) also known as B7-H1 or CD274. The 10F.2H11 antibody has been shown to sterically and functionally block PD-L1/CD80 (B7-1) interactions and does not block PD-L1/PD-1 interactions.
A2176New Anti-mouse CD8α (53-6.7)-Invivo [53-6.7] in vivo CD8+ T cell depletion Anti-mouse CD8α (53-6.7)-Invivo [53-6.7] reacts with mouse CD8α. The CD8 antigen is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR).
A2136 Anti-mouse CD40-InVivo [FGK4.5/FGK45] Anti-mouse CD40-InVivo Anti-mouse CD40-InVivo [FGK4.5/FGK45] reacts with mouse CD40 also known as Bp50. CD40 is a type I transmembrane glycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily.
A2137 Anti-mouse CD8β (Lyt 3.2)-InVivo [53-5.8] Anti-mouse CD8β (Lyt 3.2)-InVivo Anti-mouse CD8β (Lyt 3.2)-InVivo [53-5.8] reacts with mouse CD8β also known as Lyt 3.2. The CD8 antigen is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR).
A2138 Anti-mouse IL-2-InVivo [JES6-1A12] Anti-mouse IL-2-InVivo Anti-mouse IL-2-InVivo [JES6-1A12] reacts with mouse IL-2, a cytokine that is mainly produced by T cells in response to antigenic or mitogenic stimulation
A2177New Anti-mouse IFNγR (CD119)-Invivo [GR-20] in vivo/vitro IFNγR neutralization Anti-mouse IFNγR (CD119)-Invivo [GR-20] reacts with the mouse IFNγR (interferon gamma receptor) α chain also known as CD119 and IFNγ receptor 1. CD119 heterodimerizes with IFNγ receptor 2 (AF-1) to form the IFNγR, a Class II cytokine receptor.
A2140 Anti-mouse/human/rat CD47 (IAP)-InVivo [MIAP410] Anti-mouse/human/rat CD47 (IAP)-InVivo Anti-mouse/human/rat CD47 (IAP)-InVivo [MIAP410] reacts with mouse CD47 otherwise known as integrin-associated protein (IAP). CD47 is an approximately 50 kDa glycosylated five transmembrane protein that is ubiquitously expressed by both hematopoietic cells such as T and B lymphocytes, monocytes, platelets and erythrocytes and non-hematopoietic cells.
A2178New Anti-mouse/human IL-5-Invivo [TRFK5] in vivo IL-5 neutralization, in vivo eosinophil depletion Anti-mouse/human IL-5-Invivo [TRFK5] reacts with mouse and human interleukin-5 (IL-5), a 26 kDa homodimeric cytokine. IL-5 stimulates B lymphocyte differentiation and proliferation and increases the secretion of IgM and IgA.
A2175New Anti-mouse CD11c-Invivo [N418] in vivo targeting of dendritic cells Anti-mouse CD11c-Invivo [N418] reacts with mouse CD11c, the most widely used defining marker for murine dendritic cells (DCs). CD11c is also known as integrin alpha-X (Itgax) and CD11 antigen-like family member C.