抗体薬物複合体(ADC)
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抗体薬物複合体(ADC)

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S0328 MMAF MMAF (Monomethylauristatin F) is a synthetic antineoplastic agent and a potent inhibitor of tubulin polymerization. MMAF (Monomethylauristatin F) is applied as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin, ABT-414 and SGN-CD19A.
S0346 NAcM-OPT NAcM-OPT is a specific, reversible and orally bioavailable inhibitor of cullin neddylation 1 (DCN1) that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM.
S0556 ACT-389949 ACT-389949 is a potent, selective agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX) with EC50 of 3 nM for FPR2/ALX internalization into monocytes. ACT-389949 has potential for inflammatory disorders.
S0557 PNU-159682 PNU-159682 is a highly potent metabolite of the anthracycline nemorubicin (DNA topoisomerase II inhibitor) with outstanding cytotoxicity. PNU-159682 is a potent ADCs cytotoxin.
S0559 Maytansinol Maytansinol (Ansamitocin P-0) is an inhibitor of microtubule assembly that induces microtubule disassembly in vitro.
S0561 Auristatin E Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity. Auristatin E is an MMAE analog and cytotoxin in Antibody-drug conjugates (ADCs). Auristatin E inhibits cell division by blocking the polymerisation of tubulin.
S0562 Ansamitocin P 3' Ansamitocin P 3' (Antibiotic C 15003P3', Maytansinol butyrate) is an antibody drug conjugate (ADC) cytotoxin, exhibiting antitumour activity.
S0563New 10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyl paclitaxel (10-Deacetyl-7-xylosyltaxol, 7-xylosyl-10-deacetylpaclitaxel), a derivative of paclitaxel and naturally occurring xyloside isolated from Taxus chinensis, causes significant mitotic arrest in PC-3 cells followed by up-regulating expression of pro-apoptotic Bax and Bad protein, as well as down-regulating expression of anti-apoptotic Bcl-2 and Bcl-XL , which leads to a disturbance of the mitochondrial membrane permeability and to the activation of caspase-9.
S0564 SPDP SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable disulfide bonds with cysteine sulfhydryls. SPDP is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs).
S0565 DBCO-NHS ester DBCO-NHS ester is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0566 Sulfo-SMCC sodium Sulfo-SMCC sodium is a commonly-used hetero-bifunctional, noncleavable ADC crosslinker with N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.
S0567 Amino-PEG4-alcohol Amino-PEG4-alcohol is a PEG-based PROTAC linker used in the synthesis of PROTACs. Amino-PEG4-alcohol is a non-cleavable 4-unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
S0701 Conantokin G Conantokin G (Con-G, CGX-1007, Conotoxin GV, Sleeper peptide) is a selective and competitive antagonist of GluN2B receptor.
S0702New α-Conotoxin GI α-Conotoxin GI, a 13-residue peptide originally isolated from the venom of the fish-hunting cone snail Conus geographus, acts as a competitive antagonist for the muscle-type nicotinic acetylcholine receptor (nAChR) with excellent selectivity for α/δ receptor subunit binding over α/γ.
S0704 Delsoline Delsoline, a major alkaloid of Delphinium anthriscifolium Hance, has both a curare-like effect and a ganglion-blocking effect. Delsoline is used to relieve muscle tension or hyperkinesia. Delphinium anthriscifolium Hance has effects of dispelling wind and dampness, activating collaterals, and relieving pains and is used to treat rheumatism, hemiplegia, indigestion, and cough.
S1150 Paclitaxel (NSC 125973) Paclitaxel (NSC 125973, PTX, Taxol, Onxal, Abraxane) is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.
S1208 Doxorubicin (Adriamycin) HCl Doxorubicin (Adriamycin, NSC 123127, DOX, Hydroxydaunorubicin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage, mitophagy and apoptosis in tumor cells. Doxorubicin reduces basal phosphorylation of AMPK. Doxorubicin is used in the concomitant treatment of HIV-infected patients but is found to be at high risk of HBV reactivation.
S1210 Methotrexate (CL-14377) Methotrexate (CL14377, MTX, NCI-C04671, Amethopterin, WR19039, abitrexate), analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis.
S1282 Artemisinin Artemisinin (Qinghaosu, Artemisinine) is a sesquiterpene endoperoxide which is a potent antimalarial agent.
S1288 Camptothecin (NSC-100880) Camptothecin (NSC-100880, CPT, Campathecin, (S)-(+)-Camptothecin) is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM in a cell-free assay. Camptothecin induces apoptosis in cancer cells via microRNA-125b-mediated mitochondrial pathways. Phase 2.
S1339 Galanthamine HBr Galanthamine is an AChE inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase.
S1421 Staurosporine (AM-2282) Staurosporine (AM-2282, Antibiotic AM-2282, STS) is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM) in cell-free assays. Also shows inhibitory activities on other kinases, such as PKA, PKG, S6K, CaMKII, etc. Phase 3.
S1640 Albendazole (SKF-62979) Albendazole (SKF-62979) is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.
S2130 Atropine sulfate monohydrate Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery.
S2264 Artemether Artemether (SM-224, CGP 56696) is an antimalarial for the treatment of resistant strains of falciparum malaria.
S2265 Artesunate (WR-256283) Artesunate (WR-256283) is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. It is a potential inhibitor of STAT-3 and exhibits selective cytotoxicity of cancer cells over normal cells in vitro; A potent inhibitor of EXP1.
S2304 Gramine Gramine (Donaxine) is a natural indole alkaloid isolated from giant reed, acts as an active adiponectin receptor (AdipoR) agonist, with IC50 of 3.2 µM and 4.2 µM for AdipoR2 and AdipoR1, respectively. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist.
S2320 Luteolin Luteolin (Luteoline, Luteolol, Digitoflavone) is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Phase 2.
S2350 Rutin Rutin (Rutoside), a flavonol glycoside found in many plants including buckwheat; tobacco; forsythia; hydrangea; viola, etc., which possesses healthy effects for human.
S2372 Xanthone Xanthone (Genicide) is an organic compound, which can be prepared by the heating of phenyl salicylate.
S2387 Lappaconite HBr Lappaconite Hydrobromide is a kind of alkaloid extracted from Aconitum sinomontanum Nakai and has anti-inflammatory effects.
S2417 20-Hydroxyecdysone 20-Hydroxyecdysone (Ecdysterone, 20E, B-ecdysone, Commisterone, Crustecdysone) is a naturally occurring ecdysteroid hormone which controls the ecdysis (moulting) and metamorphosis of arthropods.20-Hydroxyecdysone (Ecdysterone, 20E) inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP.
S2447 Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222) Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222, Antibiotic C 15003P3) is a potent inhibitor of tubulin polymerization with IC50 of 3.4 μM.
S3035 Daunorubicin (RP 13057) HCl Daunorubicin HCl (Daunomycin, RP 13057, Rubidomycin) inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay. Daunorubicin is a topoisomerase II inhibitor that induces apoptosis.
S3604 Triptolide (PG490) Triptolide (PG490, NSC 163062) is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii. It functions as a NF-κB inhibitor with dual actions by disruption of p65/CBP interaction and by reduction of p65 protein. Triptolide (PG490) abrogates the transactivation function of heat shock transcription factor 1 (HSF1). Triptolide inhibits MDM2 and induces apoptosis through a p53-independent pathway.
S3628 BHQ BHQ (2,5-di-t-butyl-1,4-benzohydroquinone) is a potent and selective inhibitor of the sarco-endoplasmic reticulum Ca2+-ATPase (SERCA).
S3800 Lycorine hydrochloride Lycorine (Galanthidine, Amarylline, Narcissine, Licorine), a natural alkaloid extracted from the Amaryllidaceae plant family, has been reported to exhibit a wide range of physiological effects, including the potential effect against cancer. It is an HCV inhibitor with strong activity.
S3817 Harmine hydrochloride Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs) and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM.
S3854 Tetrahydropalmatine hydrochloride Tetrahydropalmatine (THP, Gindarine, 1-Tetrahydropalmitine) is an isoquinoline alkaloid found in several different plant species, mainly in the Corydalis genus (Yan Hu Suo), but also in other plants such as Stephania rotunda. It is a potent muscle relaxant.
S3883 Protopine Protopine (Corydinine, Fumarine, Biflorine, Macleyine), an alkaloid present in different plants, has been shown to exhibit a number of activities, such as inhibition of calcium influx through both voltage and receptor-operated channels and inhibition of rabbit blood platelet aggregation. It also possesses anti-cholinergic and anti-histaminic as well as anti-bacterial activities.
S3892 Isopsoralen Isopsoralen (Angelicin), also known as angelicin, is a constituent of roots and leaves of angelica with anti-inflammatory activity and regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. It also shows antiviral activity against gammaherpesviruses.
S3941 Pinocembrin Pinocembrin (Dihydrochrysin, Galangin flavanone, 5,7-Dihydroxyflavanone) is a major flavonoid molecule incorporated as multifunctional in the pharmaceutical industry. Its vast range of pharmacological activities has been well researched including antimicrobial, anti-inflammatory, antioxidant, and anticancer activities.
S4181 Nicardipine HCl Nicardipine HCl (RS-69216) is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders.
S4630 Diazoxide Diazoxide (Sch-6783, SRG-95213, Proglycem) is a well-known small molecule that activates KATP channels in the smooth muscle of blood vessels and pancreatic beta-cells by increasing membrane permeability to potassium ions.
S4737 Psoralen Psoralen (Psoralene, Ficusin, Furocoumarin) is a naturally occurring furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division.
S4776 Harmaline Harmaline, a natural occurrence β-carboline alkaloid, is a central nervous system stimulant and an acetylcholinesterase (AChR) inhibitor; also inhibits histamine N-methyltransferase.
S4859 TriacetonaMine TriacetonaMine (Tempidon, Tmpone, Odoratine, Vincubine), a member of the class of compounds known as piperidinones, is an extremely weak acidic compound found in green vegetables and tea.
S4908 SN-38 SN-38 (NK012) is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. SN-38 induces autophagy.
S5018 Mebhydrolin napadisylate Mebhydrolin Napadisylate (Diazoline, Diazolin, Incidal, Omeril) is classified as an antihistamine drug classes used to treat allergies.
S5153 Tetrahydroberberine Tetrahydroberberine (Canadine) is an isoquinoline alkaloid with micromolar affinity for dopamine D2 (antagonist, pKi = 6.08) and 5-HT1A (agonist, pKi = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors.
S5478 Dantrolene sodium Dantrolene sodium acts as a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.
S6773 Mertansine Mertansine (DM1, Maytansinoid DM1), an antibody-conjugatable maytansinoid, is a selective microtubule inhibitor that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC). Solutions are best fresh-prepared.
S7071 (+)-Bicuculline (+)-Bicuculline (d-Bicuculline) is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.
S7721 Monomethyl auristatin E (MMAE) Monomethyl auristatin E (MMAE, SGD-1010) is a synthetic antineoplastic agent, which is linked to a monoclonal antibody (MAB). It is also a microtubule-disrupting agent .
S8146 Mitomycin C Mitomycin C (Ametycine) is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.
S9018 Luteoloside Luteoloside (Cynaroside, Luteolin 7-β-D-Glucopyranoside) is a member of the flavonoids family that exhibits several bioactivities including anti-microbial and anti-cancer activities. It is an inhibitor of 3C Protease of Enterovirus 71 with an IC50 value of 0.36 mM.
S9065 Songorine Songorine, a ubiquitous alkaloid in the genus Aconitum, is a novel antagonist of the GABAA receptor in rat brain and has antiarrhythmic, antinociceptive, anti-inflammatory, regenerative and CNS-modulating properties.
S9223 Talatisamine Talatisamine, a delphinine type alkaloid extracted from Aconitum talassicum, is a newly identified K+ channel blocker with hypotensive and antiarrhythmic activities.
S9233 Imperialine Imperialine (Sipeimine, Kashmirine) is an alkaloid found in the bulbs of species of the genus Fritillaria.
S0564 SPDP SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable disulfide bonds with cysteine sulfhydryls. SPDP is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs).
S0565 DBCO-NHS ester DBCO-NHS ester is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0566 Sulfo-SMCC sodium Sulfo-SMCC sodium is a commonly-used hetero-bifunctional, noncleavable ADC crosslinker with N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.
S0567 Amino-PEG4-alcohol Amino-PEG4-alcohol is a PEG-based PROTAC linker used in the synthesis of PROTACs. Amino-PEG4-alcohol is a non-cleavable 4-unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
S0568 DBCO-acid DBCO-acid is a cleavable ADC linker applied into the synthesis of ADC linker DBCO-NHS ester and drug-linker conjugates DBCO-PEG-MMAE.
S0569 Fmoc-8-amino-3,6-dioxaoctanoic acid Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0570 Boc-NH-C6-Br Boc-NH-C6-Br is a cleavable linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0571 SPDB SPDB is a glutathione cleavable ADC linker applied into the synthesis of antibody-drug conjugate (ADCs).
S0572New SMCC SMCC (Succinimidyl-4-(N-maleimidomethyl cyclohexane)-1-carboxylate) is a hetero-bifunctional crosslinker that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. SMCC-conjugated antigen couples spleen cells to induce antigen-specific immune responses.
S0573 N-Hydroxysulfosuccinimide sodium N-Hydroxysulfosuccinimide sodium is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0574 Fmoc-NH-PEG4-CH2CH2COOH Fmoc-NH-PEG4-CH2CH2COOH (Fmoc-15-amino-4,7,10,13-tetraoxapentadecanoic acid) is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0575 Boc-NH-PEG4-CH2CH2NH2 Boc-NH-PEG4-CH2CH2NH2 a cleavable 5-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0576 NH2-PEG2-C2-Boc NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. NH2-PEG2-C2-Boc is a non-cleavable 2-unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
S0577 6-Maleimidohexanoic acid N-hydroxysuccinimide ester 6-Maleimidohexanoic acid N-hydroxysuccinimide ester (ECMS) is a useful protective group in antibody drug conjugates (ADCs).
S0578 Hydroxy-PEG4-(CH2)2-Boc Hydroxy-PEG4-(CH2)2-Boc is a uncleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0579 Boc-Gly-Gly-Phe-Gly-OH Boc-Gly-Gly-Phe-Gly-OH (GGFG) is a self-assembly of N- and C-protected tetrapeptide, a protease cleavable linker used for the antibody-drug conjugates (ADCs).
S0580 N-Boc-diethanolamine N-Boc-diethanolamine is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0582 BMPS BMPS is a noncleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0583 Hydroxy-PEG3-(CH2)2-Boc Hydroxy-PEG2-(CH2)2-Boc is an uncleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0584 Fmoc-NH-PEG1-CH2COOH Fmoc-NH-PEG1-CH2COOH is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0585 Boc-Val-Cit-OH Boc-Val-Cit-OH is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0586 Succinic anhydride Succinic anhydride (SA, Succinyl Oxide, Butanedioic Anhydride) is a cyclic anhydride that can be used in the homogeneous chemical modification of cellulose and as a noncleavable ADC linker that reacts with other compound to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide.
S0587 Mal-amido-PEG8-C2-acid Mal-amido-PEG8-C2-acid is a noncleavable ADC linker.
S0588 Propargyl-PEG6-acid Propargyl-PEG6-acid is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0589 Mal-PEG3-NHS ester Mal-PEG3-NHS ester is a noncleavable ADC linker with a Maleimide group that is used for making antibody-drug conjugates (ADCs).
S0590 Propargyl-PEG5-amine Propargyl-PEG5-amine is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs) and a PEG-based PROTAC linker applied into the synthesis of PROTACs.
S0591 Propargyl-PEG1-NHS ester Propargyl-PEG1-NHS ester is a noncleavable 1-unit PEG linker that can be used in antibody-drug-conjugation (ADC).
S0592 NH-bis(C1-Boc) NH-bis(C1-Boc) is an uncleavable linker that can be used for antibody-drug conjugates (ADCs).
S0593 Amino-PEG4-CH2COOH Amino-PEG4-CH2COOH is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. Amino-PEG4-CH2COOH is also a non-cleavable 4-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0594 Azido-PEG7-amine Azido-PEG7-amine is a non-cleavable 7-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0595 Hydroxy-PEG2-(CH2)2-Boc Hydroxy-PEG2-(CH2)2-Boc is an uncleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0596 Amino-PEG8-Boc Amino-PEG8-Boc is a cleavable 8-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0597 m-PEG6-NHS ester m-PEG6-NHS ester is a non-cleavable 5-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0598 Mal-PEG2-acid Mal-PEG2-acid is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). Mal-PEG2-acid can be conjugated to Tubulysin and its derivative cytotoxic molecule.
S0599 m-PEG7-CH2COOH m-PEG7-CH2COOH is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0600 Phe-Lys(Trt)-PAB Phe-Lys(Trt)-PAB is a cathepsin cleavable ADC linker that can be used for the antibody-drug conjugates (ADCs).
S0601 N3-PEG2-C2-NHS ester N3-PEG2-C2-NHS ester is a noncleavable 2-unit PEG linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0602 Ald-Ph-NHS ester Ald-Ph-NHS ester is an uncleavable linker for antibody-drug-conjugation (ADC).
S0603 m-PEG12-amine m-PEG12-amine is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. m-PEG12-amine is also a non-cleavable 12-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0604 m-PEG11-Amine m-PEG11-Amino is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0605 Azido-PEG4-CH2-Boc Azido-PEG4-CH2-Boc is a cleavable 4-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be applied into the synthesis of PROTACs.
S0606 Fmoc-NH-PEG3-CH2CH2COOH Fmoc-NH-PEG3-CH2CH2COOH is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0607 Fmoc-NH-PEG2-CH2CH2COOH Fmoc-NH-PEG2-CH2CH2COOH is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0608 Fmoc-NH-PEG6-CH2CH2COOH Fmoc-NH-PEG6-CH2CH2COOH is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0609 SPDV SPDV is a cleavable ADC linker that can be applied into the diagnosis and treatment of cancer or B cell proliferative disease.
S0610 SPDB-sulfo SPDB-sulfo is a glutathione cleavable ADC linker applied into the synthesis the antibody-drug conjugates (ADCs).
S0612 Propargyl-PEG7-acid Propargyl-PEG7-acid is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0613 Bis-​PEG4-​NHS ester Bis-​PEG4-​NHS ester is a noncleavable 4-unit PEG linker for antibody-drug-conjugation (ADC).
S0616 Azido-PEG2-C2-amine Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. Azido-PEG2-C2-amine is a non-cleavable 2-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0618 N-Boc-PEG2-bromide N-Boc-PEG2-bromide is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0620 DBCO-​C6-​acid DBCO-C6-acid is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). DBCO-C6-acid can be applied into the synthesis of carmaphycin analogues.
S0621 Tr-PEG5-OH Tr-PEG5-OH is a non-cleavable 5-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0622 m-PEG4-Br m-PEG4-Br is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs) for Trastuzumab. m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in vitro potency.
S0623 Bis-PEG1-NHS ester Bis-PEG1-NHS ester is a non-cleavable 1-unit PEG linker for antibody-drug-conjugation (ADC).
S0625 m-PEG7-Amine m-PEG7-Amine is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0626 DSP Crosslinker DSP Crosslinker is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0627New PDEC-NB PDEC-NB is a disulfide cleavable linker that can be applied into the synthesis of antibody-drug conjugates (ADCs).
S0629 Ald-Ph-amido-PEG4-C2-NHS ester Ald-Ph-amido-PEG4-C2-NHS ester is a non-cleavable 4-unit PEG linker for antibody-drug-conjugation (ADC).
S0630 Mal-PEG6-NHS ester Mal-PEG6-NHS ester is a non-cleavable ADC linker containing a Maleimide group, 6-unit PEG and a NHS ester.
S0631 Fmoc-NH-PEG4-CH2COOH Fmoc-NH-PEG4-CH2COOH is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0632 SIA Crosslinker SIA Crosslinker is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0633 Ald-Ph-amido-PEG4-C2-acid Ald-Ph-amido-PEG4-C2-acid is a non-cleavable linker used for the antibody-drug conjugates (ADCs).
S0634 Propargyl-PEG8-acid Propargyl-PEG8-acid is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). The ADCs can be applied into bacterial infections caused by Gram-negative bacteria.
S0635 DBCO-amine DBCO-amine is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0638 Bis-​PEG2-​NHS ester Bis-PEG2-NHS ester is a non-cleavable 2-unit PEG linker used for antibody-drug-conjugation (ADC).
S0639 m-PEG2-Amine m-PEG2-Amine is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0640 NH2-PEG5-OH NH2-PEG5-OH is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. NH2-PEG5-OH is also a non-cleavable 5-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0641 Mal-amido-PEG2-NHS ester Mal-amido-PEG2-NHS ester is a non-cleavable ADC linker containing a maleimide group and an NHS ester. The NHS ester can label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
S0642 Azido-PEG6-amine Azido-PEG6-amine is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. Azido-PEG6-amine is also a non-cleavable 6-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0643 4-N3Pfp-NHS ester 4-N3Pfp-NHS ester is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0644 Mal-C2-NHS ester Mal-C2-NHS ester is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0645 NHPI-PEG4-C2-NHS ester NHPI-PEG4-C2-NHS ester is used as a linker for antibody-drug conjugates (ADCs).
S0647 Propargyl-PEG8-NH2 Propargyl-PEG8-NH2 is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0648 Fmoc-Asp-NH2 Fmoc-Asp-NH2 is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0649 Fmoc-NH-PEG8-CH2CH2COOH Fmoc-NH-PEG8-CH2CH2COOH is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0650 m-PEG3-CH2CH2COOH m-PEG3-CH2CH2COOH is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0651New N-Butanoyl-L-homoserine lactone N-Butyryl-L-homoserine lactone (N-Butanoyl-L-homoserine lactone, N-Butyrylhomoserine lactone, C4-HSL) is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). N-Butyryl-L-homoserine lactone is a small diffusible signaling molecule involved in quorum sensing, controlling gene expression, and cellular metabolism.
S0652 Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0653 m-PEG9-Amine m-PEG9-Amine is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0654New Mal-​PEG4-​NHS ester Mal-PEG4-NHS ester is a non-cleavable ADC linker containing a Maleimide group, 4-unit PEG and an NHS ester.
S0655 Propargyl-PEG4-NHS ester Propargyl-PEG4-NHS ester is a non-cleavable 4-unit PEG linker used for antibody-drug-conjugations (ADCs).
S0656 Azido-PEG9-acid Azido-PEG9-acid is a non-cleavable 9-unit PEG ADC linker applied in the synthesis of antibody-drug conjugates (ADCs).
S0657 DSS Crosslinker DSS Crosslinker (Disuccinimidyl suberate) is a membrane permeable homobifunctional crosslinking agent and a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0658 LC-PEG8-SPDP LC-PEG8-SPDP is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0662 m-PEG8-Amine m-PEG8-Amine is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0664 m-PEG10-alcohol m-PEG10-alcohol (Decaethylene glycol monomethyl ether) is a non-cleavable 10-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). m-PEG10-alcohol is also a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs.
S0665 m-PEG2-Tos m-PEG2-Tos is an uncleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0667 m-PEG3-Amine m-PEG3-Amine is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0668 Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs.
S0669 Amino-PEG2-C2-acid Amino-PEG2-C2-acid is a cleavable 3-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0670 N3-PEG3-CH2CH2-Boc N3-PEG3-CH2CH2-Boc is a cleavable 3-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). N3-PEG3-CH2CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be applied into the synthesis of PROTACs.
S0671 Propargyl-PEG4-C2-acid Propargyl-PEG5-acid is a non-cleavable 5-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-acid can to used to synthesize ADC inhibitors of Galectin-3.
S0672 AMAS AMAS is a non-cleavable heterobifunctional crosslinker with an NHS ester and maleimide groups. AMAS allows covalent conjugation of amine- and sulfhydryl-containing molecules.
S0673 Propargyl-C2-NHS ester Propargyl-C2-NHS ester is a non-cleavable linker used for antibody-drug-conjugation (ADC).
S0674 Amino-PEG3-C2-acid Amino-PEG3-C2-acid is a cleavable PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0675 Azide-PEG5-Tos Azide-PEG5-Tos (Azido-PEG5-OTs) is a cleavable 5-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0676 m-PEG6-Amine m-PEG6-Amine is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0677 Fmoc-Phe-Lys(Trt)-PAB-PNP Fmoc-Phe-Lys(Trt)-PAB-PNP is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0678 BnO-PEG6-OH BnO-PEG6-OH is a non-cleavable 6-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0680 PDP-C1-Ph-Val-Cit PDP-C1-Ph-Val-Cit is a cleavable ADC linker that can be used for antibody-drug conjugates (ADCs).
S0681 Amino-PEG6-alcohol Amino-PEG6-OH is a non-cleavable 6-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0683 Aminoethyl-SS-ethylalcohol Aminoethyl-SS-ethylalcohol is an Alkyl-Chain-based PROTAC linker can be applied into the synthesis of PROTACs. Aminoethyl-SS-ethylalcohol is also a glutathione cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0684 Propargyl-PEG4-Tos Propargyl-PEG4-Tos is a PEG-based PROTAC linker can be applied into the synthesis of PROTACs. Propargyl-PEG4-Tos is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0685 Propargyl-PEG2-acid Propargyl-PEG2-acid is a non-cleavable 2-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0686 NH2-PEG4-CH2CH2COOH NH2-PEG4-CH2CH2COOH is a cleavable 4-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0687 NH2-PEG6-Boc NH2-PEG6-Boc is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. NH2-PEG6-Boc is also a non-cleavable 6-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0688 m-PEG8-NHS ester m-PEG8-NHS ester is a non-cleavable 8-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0689 Bis-PEG8-acid Bis-PEG8-acid is a PEG-based PROTAC linker can be applied into the synthesis of PROTACs. Bis-PEG8-acid is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0691 N-Boc-PEG4-bromide N-Boc-PEG4-bromide is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0692 N3-Ph-NHS ester N3-Ph-NHS ester is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0693 Bis-PEG3-NHS ester Bis-PEG3-NHS ester is a non-cleavable 3-unit PEG linker that can be used for antibody-drug-conjugation (ADC).
S0694 Bis-PEG5-NHS ester Bis-PEG5-NHS ester is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0695 5-Maleimidovaleric acid 5-Maleimidovaleric acid is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0696 Propargyl-PEG2-NHBoc Propargyl-PEG2-NHBoc is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be applied into the synthesis of PROTACs.
S0697 Mal-PEG2-NHS ester Mal-PEG2-NHS ester is a non-cleavable ADC linker consists of a Maleimide group, 2-unit PEG and an NHS ester.
S0698 Boc-NH-PEG4-CH2CH2COOH Boc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker can be applied into the synthesis of PROTAC. Boc-NH-PEG4-CH2CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC).
S0700 GMBS GMBS is a cross-linker with heterobifunction.
S6669 MC-Val-Cit-PAB MC-Val-Cit-PAB,also known as MC-Val-Cit-PAB-OH,is a cathepsin cleavable ADC peptide linker and is used for making ADC conjugate (antibody-drug conjugate).
S6688 Fmoc-Val-Cit-PAB Fmoc-Val-Cit-PAB (Fmoc-Val-Cit-PAB-OH) is a cleavable linker for antibody-drug conjugates (ADC).
S0699 MC-DOXHZN hydrochloride MC-DOXHZN hydrochloride is an albumin-binding prodrug of Doxorubicin with acid-sensitive properties. Doxorubicin is a DNA topoisomerase II inhibitor.
S8670 Vipivotide tetraxetan (PSMA-617) Vipivotide tetraxetan (PSMA-617) is a chemically modified PSMA(prostate-specific membrane antigen) inhibitor with a Ki of 0.37 nM.