Daunorubicin (RP 13057) HCl

For research use only. Not for use in humans.

製品コードS3035 別名:Daunomycin HCl, Rubidomycin HCl

Daunorubicin (RP 13057) HCl化学構造

CAS No. 23541-50-6

Daunorubicin HCl (Daunomycin, RP 13057, Rubidomycin) inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay. Daunorubicin is a topoisomerase II inhibitor that induces apoptosis.

サイズ 価格(税別)  
10mM (1mL in DMSO) JPY 16900
JPY 13600
JPY 46800
最寄りの販売代理店を探す

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バルク問合せ

文献中Selleckの製品使用例(48)

製品安全説明書

Antineoplastic and Immunosuppressive Antibiotics阻害剤の選択性比較

生物活性

製品説明 Daunorubicin HCl (Daunomycin, RP 13057, Rubidomycin) inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay. Daunorubicin is a topoisomerase II inhibitor that induces apoptosis.
ターゲット
DNA synthesis [1]
(Cell-free assay)
20 nM(Ki)
体外試験

At drug concentrations that reflect the peak plasma concentration after Daunorubicin administration, the primary mechanism is likely to be through interaction with topoisomerase II, which may be a primary triggering event for growth arrest and/or cell killing through a signalling pathway leading to apoptosis, at least in leukemic cells and thymocytes. The quinone structure permits daunorubicin to act as electron acceptors in reactions mediated by oxoreductive enzymes including cytochrome P450 reductase, NADH dehydrogenase, and xanthine oxidase. At Daunorubicin concentrations exceeding approximately 2–4 μM, free radical mediated toxicity and DNA cross-linking may become evident. Daunorubicin inhibits both DNA and RNA syntheses in HeLa cells over a concentration range of 0.2 through 2 μM. Daunorubicin inhibits both DNA syntheses in Ehrlich ascites tumor cells over a concentration range of 4 μM. Daunorubic triggers apoptosis at concentrations of 0.5 and 1 μM in either HL-60 or U-937 human leukemic cells. [1] Daunorubicin stimulates ceramide elevation and apoptosis in P388 and U937 cells through de novo synthesis via activation of the enzyme ceramide synthase. [2] Daunorubicin dose-dependently increases the phosphatidylserine exposure and consequent procoagulant activity of human umbilical vein endothelial cells. Daunorubicin (0.2 mM) significantly enhances the release of endothelial microparticles which are highly procoagulant in human umbilical vein endothelial cells. [3]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDA MB 361(mammary carcinoma cell line) NYfOPIRIS3m2b4TvfIlkyqCjc4PhfS=> M2jqeXRp\SClb33wc5Vv\CC5YYOgeIV{fGWmIH\vdkBqdnS{YXPlcIx2dGG{IHP5eI91d3irY3n0fUBi\2GrboP0JG1FSSCPQjCzOlEpdWGvbXHyfUBk[XKlaX7vcYEh[2WubDDsbY5mMSCneIDy[ZN{cW6pIFzhZ3ohMGKndHGt[4Ft[WO2b4Pp[IF{\SluIFnDOVA:OTdibl2= M1fSTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyM{m1OFkxLz5zMEO5OVQ6ODxxYU6=
P388 leukemia cell line NXzkR2NjS3m2b4TvfIlkyqCjc4PhfS=> MWLDc41xd3WwZDD3ZZMh\X[jbIXheIVlKG[xcjDjfZRwfG:6aXPpeJkh[WejaX7zeEBROzh6IHzleYtmdWmjIHPlcIwhdGmwZTygTWM2OD1|IH7N NWPKV2pMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC0O|kzQTdpPkGwOFc6Ojl5PD;hQi=>
Dx5 w/PSC cell lines MnXGS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmHaWIhmKGOxbYDveY5lKHejczDleoFtfWG2ZXSg[o9zKHSqZTDndo94fGhiaX7obYJqfGmxbjDv[kBFgDVidz;QV2Mh[2WubDDsbY5meyC3c3nu[{BOXFRiYYPzZZktKEmFNUC9NVQhdk1? NVi2TIVYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC2PVg1PDlpPkGwOlk5PDR7PD;hQi=>
MES-SA uterine tumor cell lines MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXXDXY4{XGinIHPvcZBwfW6mIIfhd{BmfmGudXH0[YQh\m:{IITo[UBoem:5dHigbY5pcWKrdHnvckBw\iCPRWOtV2EhfXSncnnu[UB1fW2xcjDj[YxtKGyrbnXzJJV{cW6pIF3UWEBie3OjeTygTWM2OD1yLkCyNUDPxE1? M174SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyNkm4OFQ6Lz5zME[5PFQ1QTxxYU6=
Dx5 cell lines MnnnS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVHUbIUh[2:vcH;1coQhf2G|IHX2ZYx2[XSnZDDmc5IhfGinIHfyc5d1cCCrbnjpZol1cW:wIH;mJGR5PSClZXzsJIxqdmW|IIXzbY5oKE2WVDDhd5NigSxiaXO1NF0zKM7:TR?= NWfRS3UzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC2PVg1PDlpPkGwOlk5PDR7PD;hQi=>
human epidermoid carcinoma cell line KB-3-1 M2X6VGN6fG:2b4jpZ:Kh[XO|YYm= NULFdJRDUW5idnn0do8h[3m2b4TvfIlkKGGldHn2bZR6KHejczDleoFtfWG2ZXSgeZNqdmdidHjlJIh2dWGwIHXwbYRmem2xaXSgZ4Fz[2mwb33hJINmdGxibHnu[UBMSi1|LUGsJGlEPTB;NzDuUS=> NVzKSoFyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK0OFM4PjNpPkGyOFQ{PzZ|PD;hQi=>
human uterine sarcoma cell line MES-SA M3PnNWN6fG:2b4jpZ:Kh[XO|YYm= NFjheZZKdiC4aYTyc{BkgXSxdH;4bYMh[WO2aY\peJkhf2G|IHX2ZYx2[XSnZDD1d4lv\yC2aHWgbJVu[W5idYTldolv\SC|YYLjc41iKGOnbHygcIlv\SCPRWOtV2EtKEmFNUC9NE4xPyEQvF2= NGXrZYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkS0N|c3Oyd-MUK0OFM4PjN:L3G+
Jurkat T lymphocytes MmLBR5l1d3SxeHnjxsBie3OjeR?= NIjVVJhEgXSxdH;4bYNqfHliYXfhbY5{fCCMdYLrZZQhXCCueX3wbI9kgXSnczDifUBOXFRiYYPzZZktKEmFNUC9NE4xQDJ4IN88US=> MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjN4Nk[wNkc,OTZ|Nk[2NFI9N2F-
human HeLa3 cell line NUTicXVyS3m2b4TvfIlkyqCjc4PhfS=> MnvKR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[TNiY3XscEBtcW6nIHL5JG1VXCCjc4PhfUwhUUN3ME2yMlk3KM7:TR?= NGPqZYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkm0NlA{Pyd-MU[5OFIxOzd:L3G+
NCI-H69 cell line NF;ocG9Rem:uaX\ldoF1cW:wIHHzd4F6 MVTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHTyeYche2Wwc3n0bZZmKE6FST3IOlkh[2WubDDsbY5mKGK7IFHsZY1ieiCEbIXlJIF{e2G7LDDJR|UxRTBwMTFOwG0> M2TPbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Mki2N|k{Lz5zN{K4OlM6OzxxYU6=
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L1210 MofKSpVv[3Srb36gZZN{[Xl? NF;He5FKdmirYnn0bY9vKG:oIFTORUB{gW62aHXzbZMhcW5ibX;1d4UhVDF{MUCgZ4VtdHNuIFXEOVAhRSBzIN88UU4> MnLjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwPDJ|MUixK|41OjNzOEG8M4E,
L1210 NWLpXot1TnWwY4Tpc44h[XO|YYm= M1v2UmlvcGmkaYTpc44hd2ZiUl7BJJN6dnSqZYPpd{BqdiCvb4Xz[UBNOTJzMDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKFt|SG31dollcW6nIHnuZ49zeG:{YYTpc44tKEWGNUCgQUAxNjNizszNMi=> NUOzdVhyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxNEmwOVM4Lz52OUC1N|c9N2F-
L1210 NIXXTZdHfW6ldHnvckBie3OjeR?= NGT5S4pKdmirYnn0bY9vKG:oIFTORUB{gW62aHXzbZMhcW5ibX;1d4UhVDF{MUCgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCdM1jdeIh6dWmmaX7lJIlv[2:{cH;yZZRqd25uIFXEOVAhRSByLkSg{txONg>? NWDUOpYzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxNEmwOVM4Lz52OUC1N|c9N2F-
L1210 NFv2UGRHfW6ldHnvckBie3OjeR?= MlnQTY5pcWKrdHnvckBw\iCdM1jdeZJq\GmwZTDpcoNwenCxcnH0bY9vKGmwdH:gdJJwdGmoZYLheIlv\yCOMUKxNEBk\WyuczygSWQ2OCB;IECuN|Mh|ryPLh?= NHHHO5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi94N{G2OFAyLz54N{G2OFAyRC:jPh?=
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L1210 MYHGeY5kfGmxbjDhd5NigQ>? MWrEc5NmKHKncYXpdoVlKHSxIHnubIljcXRidHjlJHJPSSC|eX70bIV{cXNiaX6gcIV2c2WvaXGgUFEzOTBiY3XscJMtKEWGNUCgQUAxNjNizszNMi=> NGCzbng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi95MkWyPVc3Lz55MkWyPVc3RC:jPh?=
L1210 MlTxSpVv[3Srb36gZZN{[Xl? M3vUbmRwe2VicnXxeYlz\WRidH:gbY5pcWKrdDD0bIUhTE6DIIP5cpRp\XOrczDpckBt\XWtZX3pZUBNOTJzMDDj[YxteyxiRVS1NEA:KDFizszNMi=> MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84OjV{OUe2K|44OjV{OUe2QE9iRg>?
MCF7 MUjDfZRwfG:6aXPpeJkh[XO|YYm= NUHMS2JCPDhiaILz MU\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlIzKM7:TT6= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF7MES0O{c,OTdzOUC0OFc9N2F-
MDA-MB-231 M{TPW2N6fG:2b4jpZ4l1gSCjc4PhfS=> MV:0PEBpenN? M3S2SWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuNlUh|ryPLh?= M4\SS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUmwOFQ4Lz5zN{G5NFQ1PzxxYU6=
HeLa NWLVdIdzS3m2b4TvfIlkcXS7IHHzd4F6 NFfTS2U1QCCqcoO= MonMR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNE4{OiEQvF2u NXfpVG8xRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPVA1PDdpPkG3NVkxPDR5PD;hQi=>
PC-3 MV\DfZRwfG:6aXPpeJkh[XO|YYm= M4fhU|Q5KGi{cx?= M3LBUWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBENTNiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvPDRizszNMi=> MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF7MES0O{c,OTdzOUC0OFc9N2F-
Yoshida sarcoma tumor cells NUKy[lJVTnWwY4Tpc44h[XO|YYm= NWPZd3Q2S2:wY3XueJJifGmxbjDpcohq[mm2aX7nJHs{UF2WZGKgbY5kd3Kyb4LheIlwdiCrbjDZc5NpcWSjIIPhdoNwdWFidIXtc5Ih[2WubIOgbY4hfmm2cn:gbY4hemG2czygTWM2OCB;IECuNFIh|ryPLh?= NWnsSHl[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUOyNlk5Pid-MUOyNlk5PjxxYU6=
HL60 MmG0RZBweHSxc3nzJIF{e2G7 NHTY[IlKdiC4aYTyc{Bkd26lZX70doF1cW:wIILldZVqemWmIITvJIlv\HWlZTDhdI9xfG:|aYOgbY4hUEx4MDDj[YxteyxiQVO1NEA:KDBwMESg{txONg>? MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjh5N{W5N{c,OTJ6N{e1PVM9N2F-
HL60R NEnBe2hCeG:ydH;zbZMh[XO|YYm= Ml7FTY4hfmm2cn:gZ49v[2WwdILheIlwdiC{ZYH1bZJm\CC2bzDpcoR2[2ViYYDvdJRwe2m|IHnuJGhNPjCUIHPlcIx{NCCDQ{WwJF0hOTBizszNMi=> NYj6e2RvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK4O|c2QTNpPkGyPFc4PTl|PD;hQi=>
HL60 NW\LTJJpS3m2b4TvfIlkcXS7IHHzd4F6 NWX2TIxZS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEx4MDDj[YxteyCjZoTldkA1QCCqcoOgZpkhfHK7cHHuJIJtfWViZYjjcJV{cW:wIH3leIhw\CxiQVO1NEA:KDBwMTFOwG0v NXTHN2t5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizN|k1PTVpPkG4N|M6PDV3PD;hQi=>
HL60 MnfWRZBweHSxc3nzJIF{e2G7 Mn65TY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDteYx1cWS{dXegdoV{cXO2YX70JIh2dWGwIFjMOlAh[2WubIOgZYZ1\XJiNEigbJJ{NCCDQ{WwJF0hOzhizszNMi=> M4fFNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6M{O5OFU2Lz5zOEOzPVQ2PTxxYU6=
HTB-81 NEnLZVFEgXSxdH;4bYNqfHliYYPzZZk> MofkR5l1d3SxeHnjbZR6KHSqYYSgZ4F2e2WmIHGgOVAmKHKnZIXjeIlwdiCrbjDhZpNwemKjbnPlJIF1KDR7MDDucUBqdiCqdX3hckBxem:|dHH0[UBk[W6lZYKgTHRDNThzIHPlcIx{KHW|aX7nJG1VWyCjc4PhfUwhTUN3MDC9JFAvODV6IN88UU4> M1jmZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzMEKwNlg2Lz5zMUCyNFI5PTxxYU6=
B16 Ml:0R5l1d3SxeHnjbZR6KGG|c3H5 NXzhS5RlS3m2b4TvfIlkcXS7IIToZZQh[2G3c3XkJIEhPTBnIILl[JVkfGmxbjDpckBi[nOxcnLhcoNmKGG2IES5NEBvdSCrbjDCNVYhdW:3c3WgcYVt[W6xbXGgZ4VtdHNidYPpcochVVSVIHHzd4F6NCCHQ{WwJF0hOC5zNjFOwG0v NGXkWno9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUCyNFI5PSd-MUGwNlAzQDV:L3G+
fibroblast (NHF) cells NIP0W5pEgXSxdH;4bYNqfHliYYPzZZk> MlLDR5l1d3SxeHnjbZR6KHSqYYSgZ4F2e2WmIHGgOVAmKHKnZIXjeIlwdiCrbjDhZpNwemKjbnPlJIF1KDR7MDDucUBqdiCwb4LtZYwhcHWvYX6g[oljem:kbHHzeEApVkiIKTDj[YxteyC3c3nu[{BOXFNiYYPzZZktKEWFNUCgQUAxNjJ{IN88UU4> NU\1OZRFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUGwNlAzQDVpPkGxNFIxOjh3PD;hQi=>
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MG 63 (6-TG R) MlzndWhVWyCjc4PhfS=> MUXxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVUdiNkOgLFYuXEdiUjmgZ4VtdHN? MmjVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
fibroblast cells NEDUN|FyUFSVIHHzd4F6 MnHydWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKGOxboTyc4whUGhid3ns[EB1gXCnIH\pZpJw[myjc4SgZ4VtdHN? Ml;6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
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他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

アッセイ
Methods Test Index PMID
Western blot
p-Chk1 / Chk1 / p-ATR / ATR ; 

PubMed: 26727128     


After Caco-2 cells were treated with or without 1 μ M daunorubicin, whole cell extracts were collected at 1, 3, 6, 12, 24, and 48 h and immunoblotted for Chk1, p-Chk1, ATR, and p-ATR. β-actin served as the loading control.

26727128
Immunofluorescence
p-Chk1; 

PubMed: 26727128     


Caco-2 cells were treated with or without 1 μ M daunorubicin for 48 h, and then fixed and stained with anti-p-Chk1 antibody and DAPI. Images were collected under a fluorescence microscope. Scale bar = 10 μm. 

26727128
Growth inhibition assay
Cell viability; 

PubMed: 30745844     


(A) Viability of AML cell lines under different concentrations of Dnr according to the CCK-8 assay. (B) IC50 of AML cell lines calculated according to the result of the CCK-8 assay.

30745844

お薦めの試験操作(参考用のみ)

溶解度 (25°C)

体外 DMSO 100 mg/mL (177.31 mM)
Water 100 mg/mL (177.31 mM)
Ethanol Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
Saline
混合させたのち直ちに使用することを推奨します。
30 mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 563.98
化学式

C27H29NO10 . HCl

CAS No. 23541-50-6
Storage powder
in solvent
別名 Daunomycin HCl, Rubidomycin HCl
Smiles CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)C)O)N)O.Cl

投与溶媒組成計算器(クリア溶液)

ステップ1:実験データを入力してください。(実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します)
投与量 mg/kg 動物平均体重 g 投与体積(動物毎) ul 動物数
ステップ2:投与溶媒の組成を入力してください。(ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください)
% DMSO % % Tween 80 % ddH2O
計算リセット

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (mg) = 濃度 (mM) x 体積 (mL) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04562792 Recruiting Drug: Daunorubicin Relapsed Pediatric ALL|Relapsed Pediatric AML|Refractory Acute Myeloid Leukemia|Refractory Acute Lymphoblastic Leukemia Children''s Mercy Hospital Kansas City May 8 2020 Phase 2
NCT03878927 Recruiting Drug: CPX-351|Drug: Gemtuzumab Ozogamicin Acute Myeloid Leukemia Weill Medical College of Cornell University|Jazz Pharmaceuticals|Pfizer August 23 2019 Phase 1
NCT03896269 Recruiting Drug: Liposome-encapsulated Daunorubicin-Cytarabine Blasts 10-19 Percent of Bone Marrow Nucleated Cells|Blasts More Than 5 Percent of Bone Marrow Nucleated Cells|High Risk Chronic Myelomonocytic Leukemia|Recurrent Chronic Myelomonocytic Leukemia|Recurrent High Risk Myelodysplastic Syndrome|Refractory Chronic Myelomonocytic Leukemia|Refractory High Risk Myelodysplastic Syndrome M.D. Anderson Cancer Center|National Cancer Institute (NCI) May 14 2019 Phase 1

技術サポート

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Handling Instructions

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Tags: Daunorubicin (RP 13057) HClを買う | Daunorubicin (RP 13057) HCl ic50 | Daunorubicin (RP 13057) HCl供給者 | Daunorubicin (RP 13057) HClを購入する | Daunorubicin (RP 13057) HCl費用 | Daunorubicin (RP 13057) HCl生産者 | オーダーDaunorubicin (RP 13057) HCl | Daunorubicin (RP 13057) HCl化学構造 | Daunorubicin (RP 13057) HCl分子量 | Daunorubicin (RP 13057) HCl代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID