DNA/RNA合成
阻害剤の選択性比較
カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
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水 | DMSO | アルコール | ||
S1166 | Cisplatin | <1 mg/mL | 60 mg/mL | '<1 mg/mL |
S1149 | Gemcitabine HCl | 19 mg/mL | <1 mg/mL | <1 mg/mL |
S1135 | Pemetrexed | 94 mg/mL | <1 mg/mL | <1 mg/mL |
S1215 | Carboplatin | 14 mg/mL | <1 mg/mL | <1 mg/mL |
S3360 | Bis(2-ethylhexyl) phthalate | ' mg/mL | ||
S3356 | Phosphonoacetic acid | 28 mg/mL | 28 mg/mL | '''28 mg/mL |
S3009 | Menthone | ' mg/mL | ||
S9718 | TK216 | <1 mg/mL | 75 mg/mL | 50 mg/mL |
S9649 | Acelarin (NUC-1031) | <1 mg/mL | 100 mg/mL | '20 mg/mL |
S8977 | BCH001 | <1 mg/mL | 84 mg/mL | 5 mg/mL |
S8850 | JH-RE-06 | <1 mg/mL | 12 mg/mL | <1 mg/mL |
S7418 | Cycloheximide | 15 mg/mL | 56 mg/mL | ''56 mg/mL |
S6848 | 3'-Fluoro-3'-deoxythymidine (Alovudine) | 20 mg/mL | 49 mg/mL | '40 mg/mL |
S0816 | Brr2 Inhibitor C9 | <1 mg/mL | 89 mg/mL | ''2 mg/mL |
S0780 | Oncrasin-1 | ' mg/mL | ||
S0469 | ML216 | ˂1 mg/mL | 38 mg/mL | ˂1 mg/mL |
S0280 | Madrasin | <1 mg/mL | 1 mg/mL | 3 mg/mL |
S0102 | L 189 | ˂1 mg/mL | 49 mg/mL | ˂1 mg/mL |
S0063 | RG3039 | <1 mg/mL | 3 mg/mL | '''<1 mg/mL |
S0054 | D-I03 | <1 mg/mL | 86 mg/mL | 10 mg/mL |
S2600 | Fexinidazole | <1 mg/mL | 56 mg/mL | <1 mg/mL |
S8932 | Remdesivir (GS-5734) | <1 mg/mL | 100 mg/mL | '''16 mg/mL |
S1491 | Fludarabine | <1 mg/mL | 57 mg/mL | <1 mg/mL |
S1224 | Oxaliplatin | 3 mg/mL | -1 mg/mL | 0.01 mg/mL |
S2684 | CX-5461 | <1 mg/mL | 0.02 mg/mL | <1 mg/mL |
S1209 | Fluorouracil (5-Fluorouracil, 5-FU) | <1 mg/mL | 26 mg/mL | <1 mg/mL |
S1156 | Capecitabine | 6 mg/mL | 72 mg/mL | 72 mg/mL |
S1229 | Fludarabine Phosphate | 2 mg/mL | 73 mg/mL | <1 mg/mL |
S1117 | Triciribine | <1 mg/mL | 64 mg/mL | <1 mg/mL |
S1516 | Cidofovir | 12 mg/mL | 2 mg/mL | <1 mg/mL |
S1648 | Cytarabine | 48 mg/mL | 1 mg/mL | <1 mg/mL |
S1714 | Gemcitabine | 52 mg/mL | 52 mg/mL | <1 mg/mL |
S1213 | Nelarabine | 3 mg/mL | 60 mg/mL | <1 mg/mL |
S1373 | Daptomycin | 100 mg/mL | 100 mg/mL | <1 mg/mL |
S3035 | Daunorubicin HCl | 100 mg/mL | 100 mg/mL | <1 mg/mL |
S1199 | Cladribine | <1 mg/mL | 57 mg/mL | <1 mg/mL |
S1192 | Raltitrexed | <1 mg/mL | 91 mg/mL | <1 mg/mL |
S1218 | Clofarabine | <1 mg/mL | 60 mg/mL | <1 mg/mL |
S1302 | Ifosfamide | 52 mg/mL | 52 mg/mL | 52 mg/mL |
S2678 | NSC 207895 | <1 mg/mL | 0.4 mg/mL | <1 mg/mL |
S1221 | Dacarbazine | 2 mg/mL | 12 mg/mL | 1 mg/mL |
S1896 | Hydroxyurea | 15 mg/mL | 15 mg/mL | <1 mg/mL |
S1807 | Aciclovir | <1 mg/mL | 45 mg/mL | <1 mg/mL |
S1299 | Floxuridine | 49 mg/mL | 49 mg/mL | 10 mg/mL |
S1305 | Mercaptopurine (6-MP) | <1 mg/mL | 30 mg/mL | <1 mg/mL |
S1384 | Mizoribine | 51 mg/mL | 1 mg/mL | <1 mg/mL |
S1949 | Menadione | <1 mg/mL | 34 mg/mL | 34 mg/mL |
S2239 | Tubacin | <1 mg/mL | 100 mg/mL | <1 mg/mL |
S1289 | Carmofur | <1 mg/mL | 52 mg/mL | 10 mg/mL |
S4227 | Fidaxomicin | <1 mg/mL | 100 mg/mL | <1 mg/mL |
S1907 | Metronidazole | <1 mg/mL | 34 mg/mL | <1 mg/mL |
S1760 | Rifapentine | <1 mg/mL | 100 mg/mL | 17 mg/mL |
S1778 | Trifluridine | 59 mg/mL | 59 mg/mL | '59 mg/mL |
S1790 | Rifaximin | <1 mg/mL | 47 mg/mL | 3 mg/mL |
S1995 | Procarbazine HCl | 52 mg/mL | <1 mg/mL | 52 mg/mL |
S1784 | Vidarabine | 3 mg/mL | 53 mg/mL | <1 mg/mL |
S1764 | Rifampin | <1 mg/mL | 100 mg/mL | <1 mg/mL |
S3001 | Clevudine | 52 mg/mL | 52 mg/mL | 4 mg/mL |
S1300 | Tegafur (FT-207) | 8 mg/mL | 40 mg/mL | 7 mg/mL |
S1826 | Nedaplatin | 18 mg/mL | <1 mg/mL | <1 mg/mL |
S7470 | Triapine | <1 mg/mL | 20 mg/mL | <1 mg/mL |
S7757 | 6-Thio-dG | <1 mg/mL | 56 mg/mL | <1 mg/mL |
S4297 | Mupirocin | 46 mg/mL | 100 mg/mL | 100 mg/mL |
S8376 | Rbin-1 | <1 mg/mL | 23 mg/mL | '1 mg/mL |
S9521 | Pentostatin | 54 mg/mL | 54 mg/mL | <1 mg/mL |
S5552 | Amenamevir | ' mg/mL | ||
S8095 | Tubercidin | <1 mg/mL | 53 mg/mL | <1 mg/mL |
S4035 | Vitamin D2 | <1 mg/mL | 20 mg/mL | 80 mg/mL |
S7975 | Favipiravir (T-705) | 5 mg/mL | 31 mg/mL | 22 mg/mL |
S8328 | CeMMEC1 HCl | <1 mg/mL | 23 mg/mL | 1 mg/mL |
S5484 | Rimantadine Hydrochloride | -1 mg/mL | 43 mg/mL | -1 mg/mL |
S4504 | 6-Mercaptopurine (6-MP) Monohydrate | <1 mg/mL | 34 mg/mL | '<1 mg/mL |
S7742 | SCR7 | <1 mg/mL | 66 mg/mL | 3 mg/mL |
S4737 | Psoralen | <1 mg/mL | 37 mg/mL | '<1 mg/mL |
S8146 | Mitomycin C | <1 mg/mL | 66 mg/mL | <1 mg/mL |
S1973 | Cyclocytidine HCl | 44 mg/mL | 10 mg/mL | <1 mg/mL |
S3641 | Osalmid | <1 mg/mL | 45 mg/mL | 45 mg/mL |
S7449 | CRT0044876 | <1 mg/mL | 41 mg/mL | 1 mg/mL |
S7445 | E3330 | <1 mg/mL | 75 mg/mL | 75 mg/mL |
S5293 | Nimustine Hydrochloride | -1 mg/mL | 61 mg/mL | -1 mg/mL |
S5297 | Vidarabine monohydrate | -1 mg/mL | 57 mg/mL | ''-1 mg/mL |
S2794 | Sofosbuvir (GS-7977) | 11 mg/mL | 100 mg/mL | 100 mg/mL |
S8434 | B02 | <1 mg/mL | 67 mg/mL | 20 mg/mL |
S8539 | TAS-102 | 15 mg/mL | 100 mg/mL | 100 mg/mL |
S7637 | DTP3 | 100 mg/mL | 100 mg/mL | 100 mg/mL |
S8144 | Halofuginone | <1 mg/mL | 20 mg/mL | <1 mg/mL |
S7679 | YK-4-279 | <1 mg/mL | 73 mg/mL | 51 mg/mL |
S4236 | Proflavine Hemisulfate | 22 mg/mL | <1 mg/mL | <1 mg/mL |
S7718 | BMH-21 | <1 mg/mL | 5 mg/mL | 2 mg/mL |
S4239 | Bergapten | <1 mg/mL | 5 mg/mL | <1 mg/mL |
S4782 | 5-methoxyflavone | -1 mg/mL | 50 mg/mL | -1 mg/mL |
S4537 | Oxolinic acid | <1 mg/mL | 0.5 mg/mL | ''<1 mg/mL |
S7546 | Pritelivir (BAY 57-1293) | <1 mg/mL | 80 mg/mL | '<1 mg/mL |
S8329 | CeMMEC13 | <1 mg/mL | 67 mg/mL | 6 mg/mL |
S5582 | Cytarabine hydrochloride | -1 mg/mL | 55 mg/mL | -1 mg/mL |
S7419 | Blasticidin S HCl | 91 mg/mL | <1 mg/mL | <1 mg/mL |
S4288 | Chloroambucil | <1 mg/mL | 60 mg/mL | '60 mg/mL |
S8246 | RK-33 | <1 mg/mL | 85 mg/mL | <1 mg/mL |
S3168 | cis-Resveratrol | <1 mg/mL | 46 mg/mL | '''46 mg/mL |
S6893 | PIN1 inhibitor API-1 | <1 mg/mL | 73 mg/mL | 2 mg/mL |
S2427 | Triglycidyl Isocyanurate (Teroxirone) | <1 mg/mL | 59 mg/mL | '<1 mg/mL |
S8326 | Saccharin 1-methylimidazole (SMI) | 53 mg/mL | 53 mg/mL | 53 mg/mL |
S1334 | Flupirtine maleate | <1 mg/mL | 84 mg/mL | 2 mg/mL |
S1214 | Bleomycin Sulfate | 100 mg/mL | 100 mg/mL | '''<1 mg/mL |
S6854 | Triazavirin | 20 mg/mL | 57 mg/mL | <1 mg/mL |
S1237 | Temozolomide | <1 mg/mL | 38 mg/mL | <1 mg/mL |
S1212 | Bendamustine HCl | 2 mg/mL | 78 mg/mL | 17 mg/mL |
S1840 | Lomustine | <1 mg/mL | 46 mg/mL | <1 mg/mL |
S7918 | Bromodeoxyuridine (BrdU) | <1 mg/mL | 61 mg/mL | 2 mg/mL |
S4888 | Guanine | <1 mg/mL | 0.1 mg/mL | <1 mg/mL |
S5505 | 2’-deoxyuridine | -1 mg/mL | 45 mg/mL | -1 mg/mL |
S6359 | Purine | -1 mg/mL | 24 mg/mL | -1 mg/mL |
S4194 | Azaguanine-8 | <1 mg/mL | 6 mg/mL | <1 mg/mL |
S4803 | Thymidine | -1 mg/mL | 48 mg/mL | -1 mg/mL |
S1981 | Adenine | <1 mg/mL | <1 mg/mL | '<1 mg/mL |
S1983 | Adenine HCl | 4 mg/mL | 8 mg/mL | <1 mg/mL |
S1982 | Adenine sulfate | 2 mg/mL | <1 mg/mL | <1 mg/mL |
S6077 | Cytidine 5′-triphosphate (disodium salt) | -1 mg/mL | 18 mg/mL | -1 mg/mL |
S5374 | 5'-Cytidylic acid | 64 mg/mL | <1 mg/mL | -1 mg/mL |
S5384 | UTP Trisodium Salt | 100 mg/mL | <1 mg/mL | -1 mg/mL |
S3190 | N6-methyladenosine (m6A) | 14 mg/mL | 47 mg/mL | 2 mg/mL |
S2029 | Uridine | 49 mg/mL | 49 mg/mL | <1 mg/mL |
S9382 | Thymine | -1 mg/mL | 25 mg/mL | -1 mg/mL |
DNA/RNA Synthesis製品
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
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S1166 |
CisplatinCisplatin (cisplatinum, cis-diamminedichloroplatinum II, CDDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. Cisplatin activates ferroptosis and induces autophagy. Solutions are best fresh-prepared. |
![]() ![]() Cell viabilities with increasing concentrations of cisplatin (CP) and doxorubicin (DOXO) under normoxic and hypoxic condition for 48 hours were determined by MTT assay. IC50 values are presented as the means ?SDs (n=4) and * denotes p<0.05. |
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S1149 |
Gemcitabine HClGemcitabine HCl (LY188011) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. |
![]() ![]() RNA incorporating drugs induce SG assembly. HeLa cells were treated with the RNA incorporating agents 5-azacytidine (50 uM) and 6-thioguanine (10 uM), or the DNA incorporating agents trifluorothymidine (10 uM) and gemcitabine (100 nM) for 72 h. Subsequently, the cellular localization of the SG marker protein TIAR (green) and the P-body marker protein DCP1 (red) was analyzed. Nuclei were stained with Hoechst. Scale bars represent 20 um. |
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S1135 |
PemetrexedPemetrexed (LY-231514) is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis. |
![]() ![]() Role of PARP and BER in the synergy between PTX and GMX in A549 cells. Cells were pretreated ±1 umol/L olaparib (2 hours) then sequentially ±150 nmol/L PTX (24 hours), then ± GMX 12 nmol/L (48 hours). PAR modification of proteins and γ-H2AX levels were measured in extracts treated as in A by Western blotting.
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S1215 |
CarboplatinCarboplatin (JM-8, CBDCA, NSC 241240) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. Solutions are best fresh-prepared. |
![]() ![]() Detection of apoptotic responses was found to increase in epimorphin-treated A1847 with increasing concentrations of carboplatin compared to those of the untreated controls. Data were normalized to the controls and are represented as means ± S.D. [*p<0.05 compared with control]. Images of apoptotic cells were captured at 10X magnification, with at least 3 images per well, using an upright phase-contrast microscope (T3.15A; Fisher Scientific). |
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S3360新 |
Bis(2-ethylhexyl) phthalateBis(2-ethylhexyl) phthalate (Dioctyl phthalate, DOP, Diplast O, ESBO-D 82, Ergoplast FDO, Ergoplast FDO-S, Etalon) induces DNA strand breaks and gene expression alterations in larval zebrafish Danio rerio. |
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S3356新 |
Phosphonoacetic acidPhosphonoacetic acid (PAA) is an active endogenous metabolite that possesses a restricted potential to block DNA biosynthesis. Phosphonoacetic acid exhibits anti-viral activities. |
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S3009新 |
MenthoneMenthone is one of the main volatile components of the essential oil of peppermint (Mentha piperita L.). Menthone is used as antioxidant agent and has a good compensatory effect with significant reduction in DNA damages in sperm cells. |
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S9718新 |
TK216TK216 is a potent inhibitor targeting E26 transformation specific (ETS) factors via blocking the protein-protein interaction with RNA helicases. TK216 exhibits antilymphoma activity. |
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S9649新 |
Acelarin (NUC-1031)Acelarin (NUC-1031, Fosgemcitabine palabenamide, CPF-31, MTL-007, GTPL7389), a prodrug based on an aryloxy phosphoramidate derivative of gemcitabine, is a DNA synthesis inhibitor with EC50 of 0.2 nM. |
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S8977新 |
BCH001BCH001 is a specific PAPD5 inhibitor that restores telomerase activity and telomere length in dyskeratosis congenita (DC) patient induced pluripotent stem cells. PAPD5 is a noncanonical poly(A) polymerase with an unusual RNA-binding motif. |
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S8850新 |
JH-RE-06JH-RE-06 is a potent REV1-REV7 interface inhibitor with an IC50 of 0.78 μM and Kd value of 0.42 μM, disrupting REV1-POL ζ-mediated mutagenic translesion synthesis (TLS). |
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S7418新 |
CycloheximideCycloheximide (Actidione, Naramycin A, CHX), an antifungal antibiotic, is an eukaryote protein synthesis inhibitor with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively. Cycloheximide suppresses ferroptosis and inhibits autophagy. |
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S6848新 |
3'-Fluoro-3'-deoxythymidine (Alovudine)3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer. |
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S0816新 |
Brr2 Inhibitor C9Brr2 inhibitor C9 (Brr2 Inhibitor 9) is an allosteric inhibitor of the spliceosomal RNA helicase Brr2. Brr2 is implicated in autosomal-dominant retinitis pigmentosa a group of progressive retinal degenerative disorders. |
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S0780新 |
Oncrasin-1Oncrasin-1 (Onc-1) is a potent RNA polymerase II inhibitor with antitumor activity that kills various human lung cancer cells with K-Ras mutations. Oncrasin-1 drives abnormal aggregation of protein kinase C iota (PKCι) in nucleus of sensitive cells but not in resistant cells. |
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S0469新 |
ML216ML216 (CID-49852229) is a potent and selective inhibitor of the DNA unwinding activity of BLM(Bloom’s syndrome protein) with antitumor activity. ML216 inhibits helicases with IC50 of 0.97 μM and 2.98 μM for BLM636-1298 and BLMfull-length, respectively. |
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S0280新 |
MadrasinMadrasin (DDD00107587) is a potent and cell-penetrant pre-mRNA splicing inhibitor. Madrasin interferes with the early stages of spliceosome assembly and stalls spliceosome assembly at the A complex. |
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S0102新 |
L 189L 189 is a novel human DNA ligase inhibitor with IC50 of 5 μM, 9 μM and 5 μM for hLigI, hLigIII and hLigIV, respectively. L 189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L 189 specifically sensitizes cancer cells to DNA damage. |
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S0063新 |
RG3039RG3039 (PF-06687859, PF 6687859, Quinazoline 495) is an orally bioavailable and brain-penetrant inhibitor of the mRNA decapping enzyme DcpS with IC50 of 4.2 nM and IC90 of 40 nM, respectively. |
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S0054新 |
D-I03D-I03 is a selective inhibitor of RAD52 with Kd of 25.8 µM. D-I03 inhibits ssDNA annealing by RAD52 and D-loop formation with IC50 of 5 µM and 8 µM, respectively. |
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S2600新 |
FexinidazoleFexinidazole (HOE-239, Fexinidazole Winthrop) is a 5-nitroimidazole derivative. Fexinidazole is a DNA synthesis inhibitor and the only, all-oral agent for Human African Trypanosomiasis(HAT or sleeping sickness). |
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S8932新 |
Remdesivir (GS-5734)Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV. |
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S1491 |
FludarabineFludarabine (FaraA, Fludarabinum) is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis. |
![]() ![]() Normal human KC pretreated with STAT1 inhibitor (fludarabine [10 uM]) or STAT3 inhibitor (STA-21 [2 uM]) for 24 h. The mRNA levels of hBD2 and hBD3 were assessed by qRT-PCR.
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S1224 |
OxaliplatinOxaliplatin (L-OHP) is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells. DMF is recommended for dissolution. Solutions are best fresh-prepared. |
![]() ![]() Immunocytochemical staining of SW620 (metastatic) cells after treatment with 10 uM oxaliplatin (F) or 10 uM ginsenosides 20(S)-Rg 3 (G) and negative staining (H). Cells demonstrated differential expression of histone H4. |
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S2684 |
CX-5461CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116, A375, and MIA PaCa-2 cells, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation. |
![]() ![]() The specific Pol I inhibitor CX-5461 causes nucleolar disruption, blocks LTP maintenance and Fsk-induced synthesis of new rRNA. DAPI staining (blue; A, B,C) shows the area of the nucleus. Nomarski images (grey; G, H,I) show the area of the nuclei and nucleoli (arrowheads). Application of Pol I specific inhibitor CX-5461 (200 nM) causes nucleolar disruption as indicated by the distribution of fibrillarin (green); compare A, D to B, E and C, F.
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S1209 |
Fluorouracil (5-Fluorouracil, 5-FU)Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV. |
![]() ![]() DNA-PKcs suppression mediated ROS production and GSH content in HepG2 cells exposed to CDDP and 5-Fu. a DNA-PKcs inhibition promoted ROS production in HepG2 cells treated with indicated concentrations of CDDP and 5-Fu. DCFH-DA fluorescent analysis was performed to assess the ROS level. Data presented were mean ?SD of three independent experiments.
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S1156 |
CapecitabineCapecitabine (RO 09-1978) is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU. Capecitabine treatment of HCT-15 cells causes condensation of DNA and induces apoptosis. |
![]() ![]() Growth curve of human colon cancer xenografts in nude mice treated with orally administered vehicle or capecitabine at 360 mg/kg (n = 10–12 per cell line). |
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S1229 |
Fludarabine PhosphateFludarabine Phosphate (F-ara-A, NSC 312887) is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis. |
![]() ![]() Imatinib mesylate (IM) in combination of F-AMP significantly inhibits Ki67 and c-KIT expression in GIST-T1 tumor xenografts. Tumors were collected on the day after the last treatment and were then subjected to H&E staining and immunohistochemical detection of Ki67, c-KIT, and cleaved caspase-3 expression. Representative images of H&E staining and immunohistochemical staining of Ki67, c-KIT, and cleaved caspase-3 in mice tumors. Arrows indicate the decrease in cellularity and the increase in stromal fibrosis. Magnification, x 400.
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S1117 |
TriciribineTriciribine (NSC 154020, VD-0002, vqd-002, API-2) is a DNA synthesis inhibitor, also inhibits Akt in PC3 cell line and HIV-1 in CEM-SS, H9, H9IIIB, U1 cells with IC50 of 130 nM and 20 nM, respectively; does not inhibit PI3K/PDK1; 5000-fold less active in cells lacking adenosine kinase. Phase 1/2. |
![]() ![]() Effect of triciribine on the migration of (A) FaDu and (B) Hep2 cells. The cells were treated with 5 µM triciribine for different periods of time. *P<0.05 vs. control. Hpf, high-power field. |
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S1516 |
CidofovirCidofovir (HPMPC) suppresses virus replication by selective inhibition of viral DNA synthesis. |
![]() ![]() The copy numbers of the intracellular viral DNA were directly extracted from cells and were quantified by qPCR using primers specific for the KSHV ORF73 gene. Then each sample was normalized to the amount of the GAPDH gene (C), CDV (20 µM) was used as a positive control. CDV:Cidofovir. |
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S1648 |
CytarabineCytarabine (Cytarabin, Ara-C, Arabinofuranosyl Cytidine) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. Cytarabine induces autophagy and apoptosis. |
![]() ![]() Viability and CI vs Fa after 24-h exposure to cytarabine alone or in combination with ABT-199 in Riva, U2932 and VavP-Bcl2/c-MYC murine tumor cells. Viability shown at 500 nM (500 ng/ml for cytarabine; quadruplicates±s.e.m.).
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S1714 |
GemcitabineGemcitabine (LY-188011, NSC 613327), a nucleic acid synthesis inhibitor, is a very potent and specific deoxycytidine analogue, used as chemotherapy. Gemcitabine induces a potent p53-dependent apoptosis. |
![]() ![]() RNA incorporating drugs induce SG assembly. HeLa cells were treated with the RNA incorporating agents 5-azacytidine (50 uM) and 6-thioguanine (10 uM), or the DNA incorporating agents trifluorothymidine (10 uM) and gemcitabine (100 nM) for 72 h. Subsequently, the cellular localization of the SG marker protein TIAR (green) and the P-body marker protein DCP1 (red) was analyzed. Nuclei were stained with Hoechst. Scale bars represent 20 um. |
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S1213 |
NelarabineNelarabine (506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells. |
![]() ![]() b) Western blot analysis documenting cleavage of caspase-8, caspase-9, caspase-3, and PARP by nelarabine. Cells were treated with nelarabine (5 μM for JURKAT, P12-ICHIKAWA, and DND-41 cells, 2 μM MOLT-4 cells) for the indicated times, collected, and then lysed. Fifty micrograms of each lysate were electrophoresed on SDS-PAGE gels followed by transfer onto a nitrocellulose membrane. c) Nelarabine induces a decrease in the phosphorylation status of critical components of the PI3K/AKT/mTOR signaling pathway, as well as p-ERK (Thr202) levels in T-ALL sensitive cell lines. Western blot analysis documenting the reduction of p-AKT (Ser473), p-S6RP, p-GSK3β (Ser9), and p-ERK (Thr202). Antibody to β-actin served as a loading control. Molecular weights are indicated on the right
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S1373 |
DaptomycinDaptomycin (LY146032) is a novel antibiotic with rapid in vitro bactericidal activity against gram-positive organisms. |
![]() ![]() Same experiment as in Figure 2 with fluorescent daptomycin shown as confocal images. A 7/3 DOPC/DOPG GUV (including 1% Rh-PE) was introduced at time zero into a solution containing 1 uM daptomycin with 0.5 uM BODIPY-daptomycin and 1 mM Ca2+. To show colocalization of lipid and peptide in aggregates, confocal images were taken: red for RH-PE and green for BODIPY-daptomycin. As the protrusion length decreased, aggregates appeared on the GUV surface containing both lipid and peptide. The scale bar is 10 um.
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S3035 |
Daunorubicin HClDaunorubicin HCl (Daunomycin) inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay. Daunorubicin is a topoisomerase II inhibitor that induces apoptosis. |
![]() ![]() A) MV411 or B) Kasumi 1 cells were incubated with YM155 (0.25 x IC50) in the presence or absence of i) 0.5 x IC50 or ii) 1 x IC50 of Daunorubicin or iii) 0.5 x IC50 or iv) 1 x IC50 of Cytarabine for 72h. Following 72h treatment, cells were subject to a resazurin reduction assay. Percentages were normalised to DMSO controls. Column, mean of 3 independent experiments; Bars, SEM. *p<0.05, **p<0.01, ***p<0.005. Students t-test. Similar trends were observed with 0.5 x and 1 x IC50 of YM155 in combination with Daunorubicin or Cytarabine (data not shown). |
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S1199 |
CladribineCladribine (2-CdA, 2-chlorodeoxyadenosine) is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively. |
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S1192 |
RaltitrexedRaltitrexed (ZD-1694) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth. |
![]() ![]() Fig. 1. Raltitrexed dose-response curve. HEK293 parental and MRP5 transfected cells were plated in a 96-well plate at a density of 4000 cells/well in complete DMEM (10% FBS, 1% Pencillin/streptomycin) and allowed to incubate for 24h at 37°C, 5% CO2. Raltirexed was added and the cells allowed to incubate for 72h. Total DNA present in each well was then quantified using Cyquant® cell proliferation assay. Results show Total DNA as % of the DMSO-only control wells. Experiment was done in triplicate. |
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S1218 |
ClofarabineClofarabine inhibits the enzymatic activities of ribonucleotide reductase (RNR) (IC50 = 65 nM) and DNA polymerase. Clofarabine induces autophagy and apoptosis. |
![]() ![]() Immunoblot analysis of cell lysates of NCI-H929 cells treated with CLO (5 μM, 3-48 h) GAPDH served as the loading control for each membrane, and data are representative of at least two independent experiments |
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S1302 |
IfosfamideIfosfamide (NSC109724, Isophosphamide) is a nitrogen mustard alkylating agent used in the treatment of cancer. |
![]() ![]() Chemotherapeutic response. Ifosfamide was applied at different concentrations on Lipo-DUE1, Lipo246, and PLS-1 for 72 h. Subsequently, cell viability was determined by MTS assay at a wavelength of 490 nm. Values represent the mean±S.D. of triplicates
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S2678 |
NSC 207895NSC 207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase. |
![]() ![]() Median overall survival of mice (n = 5 mice in vehicle and PYR-41; n = 4 mice in NSC group) inoculated with IOWA-1T xenografts were increased to 43 ± 0.5 and 39 ± 2 days with PYR-41 (PYR) and NSC-207895 (NSC), respectively, compared with a vehicle-treated control group 33 ± 1 days (*p < 0.05).
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S1221 |
DacarbazineDacarbazine (DTIC-Dome) is a triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis; used in the treatment of various cancers. |
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S1896 |
HydroxyureaHydroxyurea (nci-c04831, nsc32065) is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. Hydroxyurea activates apoptosis and autophagy. Hydroxyurea is used to treat HIV infection. |
![]() ![]() Lethally irradiated C57BL/6 recipient mice were injected with a 1:1 mixture of GFP+JAK2(V671F) and wild-type bone marrow cells. Five weeks later, mice were treated with vehicle (C), hydroxyurea (H; 30 mg/kg twice daily IP), ruxolitinib (R; 30 mg/kg twice daily oral gavage), BMN673 (B; 0.33 mg/kg IV), H+R, H+B, R+B, and H+R+B for 3 weeks. Percentage of GFP+JAK2(V617F) was measured in (panel B) bone marrow cells, (panel C) splenocytes, and (panel D) peripheral blood leukocytes; (panel E) number of GFP+JAK2(V617F) Lin−Sca1+c-Kit+ (LSK) cells per 106 bone marrow cells was calculated, too. *P < .05, **P < .05, and ***P < .05 when compared with control, single treatment, and double treatment, respectively, from 6 to 7 mice using the Student t test.
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S1807 |
AciclovirAcyclovir (Acyclovir, Acycloguanosine, Zovirax) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells. |
![]() ![]() (A) HONE1 and (B) HK1-EBV cells were treated with TPA (40 ng/ml) and SB (3 mM) for EBV induction. After 3 h, uninduced and induced HONE1 and HK1-EBV cells were treated with the vehicle control (0.006% DMSO) or indicated concentrations of berberine for 48 h. Subsequently, the culture medium was harvested for quantitative-PCR analysis with EBNA1 primers. Each sample was normalized to the amount of the GAPDH gene; *p<0.05, compared with the control group.
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S1299 |
FloxuridineFloxuridine (Deoxyfluorouridine, FUDR, NSC 27640) is an antineoplastic antimetabolite, used in the treatment of colon carcinoma and colorectal cancer that has metastasized to the liver. |
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S1305 |
Mercaptopurine (6-MP)Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. |
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S1384 |
MizoribineMizoribine (Bredinin, NSC 289637) is an imidazole nucleoside and an immunosuppressant that inhibits HCV RNA replication with IC50 of ~ 100 μM for anti-HCV activity. Mizoribine is a selective inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH) and guanosine monophosphate synthetase. Mizoribine also inhibits SARS-CoV. |
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S1949 |
MenadioneMenadione(Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement. |
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S2239 |
TubacinTubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1. Tubacin reduces the replication of the Japanese Encephalitis Virus via the decrease of viral RNA synthesis. |
![]() ![]() Verification of Hdac6 deletion in knockout MEFs. Expression of HDAC6 and acetylation of tubulin were analyzed by immunoblotting.
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S1289 |
CarmofurCarmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. |
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S4227 |
FidaxomicinFidaxomicin (OPT-80, PAR-101) is a narrow spectrum macrocyclic antibiotic that inhibits RNA polymerase sigma subunit. |
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S1907 |
MetronidazoleMetronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa. |
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S1760 |
RifapentineRifapentine (MDL473) is an antibiotic, which inhibits DNA-dependent RNA polymerase activity, used to treat tuberculosis. |
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S1778 |
TrifluridineTrifluridine (NSC 529182, NSC 75520) is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye. |
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S1790 |
RifaximinRifaximin is a RNA synthesis inhibitor by binding the β subunit of the bacterial DNA-dependent RNA polymerase, used to treat traveler's diarrhea caused by certain bacteria. |
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S1995 |
Procarbazine HClProcarbazine HCl (NSC-77213) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound, used for the treatment of Hodgkin's lymphoma. |
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S1784 |
VidarabineVidarabine is an antiviral drug by interfering with the synthesis of viral DNA, used to treat herpes simplex and varicella zoster viruses. |
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S1764 |
RifampinRifampin (Rimactane, Rifampicin) is a DNA-dependent RNA polymerase inhibitor, used to treat a number of bacterial infections. |
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S3001 |
ClevudineClevudine is an antiviral drug for the treatment of hepatitis B. |
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S1300 |
Tegafur (FT-207)Tegafur (FT-207, NSC 148958) is a substance being used in the treatment of some types of cancer. |
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S1826 |
NedaplatinNedaplatin is a derivative of cisplatin and DNA damage agent for tumor colony forming units with IC50 of 94 μM. |
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S7470 |
TriapineTriapine (3-AP) is a potent ribonucleotide reductase (RNR) inhibitor with broad spectrum antitumor activity by inhibiting DNA synthesis. Phase 2. |
![]() ![]() (a) Quantification of p-RPA/ Rad51, 53BP1 and γH2AX in GBM01 cells treated with DMSO or triapine. (b) Quantification of p-RPA/Rad51, 53BP1 and γH2AX in GBM02 cells treated with DMSO or triapine.
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S7757 |
6-Thio-dG6-thio-dG is a nucleoside analog and telomerase substrate. |
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S4297 |
MupirocinMupirocin is an isoleucyl t-RNA synthetase inhibitor, used in the treatment of bacterial skin infections. |
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S8376 |
Rbin-1Rbin-1 (Ribozinoindole-1) is a potent chemical inhibitor of eukaryotic ribosome assembly. It inhibits recombinant full-length Mdn1's ATPase activity in vitro. |
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S9521 |
PentostatinPentostatin is a potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. |
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S5552 |
AmenamevirAmenamevir (ASP2151) is a potent helicase-primase inhibitor and a novel class of antiviral agent. |
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S8095 |
TubercidinTubercidin (7-deaza-adenosine), an adenosine analogue, is a nucleoside antibiotic. It is incorporated into DNA and inhibits polymerases, thereby inhibiting DNA replication and RNA and protein synthesis. This agent also exhibits antifungal and antiviral activities. |
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S4035 |
Vitamin D2Vitamin D2 (Ergocalciferol) is a selective inhibitor of mammalian DNA polymerase A (pol A) with IC50 of 123 μM. |
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S7975 |
Favipiravir (T-705)Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections. |
![]() ![]() (A) BoDV-1 infection was measured by IFA. BoDV-1 P40 was detected with a primary monoclonal antibody (red), nuclei were stained with DAPI (blue), merged image (scale bars: 50 μm). Favipiravir: T-705
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S8328 |
CeMMEC1 HClCeMMEC1 is an N-methylisoquinolinone derivative that inhibits the second bromodomain of TAF1 (IC50=0.9 μM). |
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S5484 |
Rimantadine HydrochlorideRimantadine is an RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza. It works by inhibiting a viral protein called M2, which normally mediates the transport of acid ions across the influenza virion shell. |
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S4504 |
6-Mercaptopurine (6-MP) Monohydrate6-Mercaptopurine (6-MP) Monohydrate is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. |
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S7742 |
SCR7SCR7 is a specific DNA Ligase IV inhibitor, which blocks nonhomologous end-joining (NHEJ). |
![]() ![]() The start codon CUG of PTEN-long was mutated to AUG and PTENlong expression is significantly increased. gRNA1 and gRNA2 have similar efficiency in driving PTEN-long expression (lanes 1 and 2). Combined gRNA1 and gRNA2 (lane 3) did not enhance PTEN-long expression compared to lane 1 and 2. The ssODN is required for mutation of CTG to ATG through HDR and without which PTEN-long is not expressed (lane 4). PTEN-long cDNA cloned into pcDNA3.1 with CTG to ATG mutation was highly expressed in transfected HEK293T cells (lane 5). Lane 6 is protein ladder. Lanes 7–10 indicate that the combination of gRNA and ssODN is required to facilitate HDR occurrence and double-strand DNA break. |
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S4737 |
PsoralenPsoralen (Psoralene, Ficusin, Furocoumarin) is a naturally occurring furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division. |
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S8146 |
Mitomycin CMitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner. |
![]() ![]() MTT results of three HCC cell lines at 72 h after indicated treatments. Three independent experiments were carried out.
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S1973 |
Cyclocytidine HClCyclocytidine (NSC 145668) is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia. |
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S3641 |
OsalmidOsalmid suppresses ribonucleotide reductase (RR) activity in a concentration-dependent manner, with a 50% RR activity-inhibitory concentration (IC50) of 8.23 μM. |
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S7449 |
CRT0044876CRT0044876 (NSC 69877, 7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM. |
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S7445 |
E3330E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity. |
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S5293 |
Nimustine HydrochlorideNimustine Hydrochloride (Nidran) is the hydrochloride salt of nimustine, a nitrosourea with antineoplastic activity that alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death. |
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S5297 |
Vidarabine monohydrateVidarabine (Spongoadenosine, Vira-A) is a nucleoside antibiotic with antiviral acitivity that interferes with the synthesis of viral DNA. It is used to treat herpes simplex and varicella zoster viruses. |
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S2794 |
Sofosbuvir (GS-7977)Sofosbuvir (PSI-7977, GS-7977) is a HCV NS5B polymerase inhibitor for the treatment of chronic hepatitis C virus (HCV) infection. |
![]() ![]() Representative confocal microscope image showing phosphorylated Drp1 translocation to mitochondria and mitochondrial fission in the presence of Sofosbuvir. At 24 hours after treatment with Sofosbuvir (100 nM), Huh7 cells were immunostained with antibodies against TOM20 (red) and p-Drp1 (S616) (green). Nuclei are demarcated with white dotted circles. Treated (+) and untreated (–) cells are marked. In the zoomed images, the arrows indicate the colocalization of TOM20 and p-Drp1 (S616) in Sofosbuvir-treated cells (yellow spots).
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S6115 |
Pyridoxal 5′-phosphate hydratePyridoxal 5′-phosphate (pyridoxal phosphate, Vitamin B6 phosphate, PAL-P, PLP), a vitamin B6 phosphate, is a coenzyme in a variety of enzymatic reactions. |
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S8434 |
B02B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM). |
![]() ![]() HEK 293T cells were transfected with a total of 6 μg of plasmid DNA (2 μg pSG-I-SceI-HA, 2 μg pcDNA-HBZ-Myc-His or empty vector, and 2 μg the pDR-GFP reporter) and treated with 20 μM B02 for 48 h where indicated. Data shown are averages of results from three independent experiments, and error bars represent SEM (*, P ≤ 0.05 by Student's t test).
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S8539 |
TAS-102TAS-102 is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride. |
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S7637 |
DTP3DTP3 is a selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor and is able to restore MKK7/JNK activation. DTP3 inhibits cancer-selective NF-κB survival pathway. |
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S8144 |
HalofuginoneHalofuginone is the competitively inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in mammal. |
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S3669 |
CarmustineCarmustine (bis-chloroethylnitrosourea, BCNU, BiCNU) is a cell-cycle phase nonspecific alkylating antineoplastic agent and used in the treatment of brain tumors and various other malignant neoplasms. |
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S7679 |
YK-4-279YK-4-279 is a potent inhibitor of EWS-FLI1 binding to RNA helicase A (RHA). |
![]() ![]() YK-4-279-induced cell apoptosis of NB cells by Western blot assay. SH-SY5Y cells were treated with YK-4-279 (0, 0.1 μM, 0.3 μM, 1 μM, 3 μM) for 24 h. Whole cell lysates were subjected to SDS-PAGE and immunoblotted with antibodies against PARP and Caspase 3 to detect apoptosis. β-actin was detected as loading control. YK-4-279-induced apoptosis of NB cell line SH-SY5Y by FACS. Cells were treated with YK-4-279 (0, 1 μM, 3 μM) for 24 h, and then stained by PI and analyzed by FACS.
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S4236 |
Proflavine HemisulfateProflavine Hemisulfate is a topical antiseptic by interchelating DNA, thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands. |
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S7718 |
BMH-21BMH-21 is a DNA intercalator, which binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription. |
![]() ![]() Pharmacological and siRNA perturbations in HEK293 cells suggest that mTORC1 also modulates cytoplasmic rheology through ribosome crowding in mammals.
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S4239 |
BergaptenBergapten is a psoralen that can be photoactivated and is capable of crossing-linking DNA, covalently modifying proteins and lipids, and consequently inhibiting cell replication. |
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S4782 |
5-methoxyflavone5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. |
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S4537 |
Oxolinic acidOxolinic acid (Urinox, NSC 110364) is a quinolone antibiotic, inhibiting the enzyme DNA gyrase and DNA synthesis.It also acts as a dopamine reuptake inhibitor. |
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S7546 |
Pritelivir (BAY 57-1293)Pritelivir (BAY 57-1293, AIC316) is a potent helicase primase inhibitor, exhibiting antiviral effect on herpes simplex virus (HSV) with IC50 of 20 nM for both HSV-1 and HSV-2. |
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S8329 |
CeMMEC13CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 µM). |
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S5582 |
Cytarabine hydrochlorideCytarabine is a pyrimidine nucleoside analog that is used mainly in the treatment of leukemia. It is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. |
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S7419 |
Blasticidin S HClBlasticidin S HCl is a nucleoside antibiotic isolated from Stretomyces girseochromogenes, and acts as a DNA and protein synthesis inhibitor, used to select transfected cells carrying bsr or BSD resistance genes. |
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S4288 |
ChloroambucilChloroambucil (Chlorambucil) is a nitrogen mustard alkylating agent, used in the treatment of chronic lymphocytic leukemia. |
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S8246 |
RK-33RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells. |
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S3168新 |
cis-Resveratrolcis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. Resveratrol also inhibits a wide spectrum of targets including 5-lipoxygenase (LOX), cyclooxygenase (COX), IKKβ, DNA polymerases α and δ with IC50 of 2.7 μM, <1 μM, 1 μM, 3.3 μM and 5 μM, respectively. |
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S6893新 |
PIN1 inhibitor API-1PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor with IC50 of 72.3 nM. PIN1 inhibitor API-1 targets Pin1 peptidyl-prolyl isomerase domain and inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 up-regulates miRNA biogenesis by retaining active XPO5 conformation and suppresses HCC development. |
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S2427新 |
Triglycidyl Isocyanurate (Teroxirone)Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry. |
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S8326 |
Saccharin 1-methylimidazole (SMI)Saccharin 1-methylimidazole (SMI) is considered a general-purpose activator for DNA and RNA synthesis. |
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S1334 |
Flupirtine maleateFlupirtine maleate is the salt form of Flupirtine, which is a centrally acting non-opioid analgesia, is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties. |
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S9603新 |
LurbinectedinLurbinectedin (PM01183, PM-1183, LY-01017, Tryptamicidin, Zepsyre, ZEPZELCA), a DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity. Lurbinectedin inhibits RMG1 and RMG2 cell growth with IC50 of 1.25 nM and 1.16 nM, respectively. |
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S1214 |
Bleomycin SulfateBleomycin Sulfate (NSC125066) is a glycopeptide antibiotic and an anticancer agent for squamous cell carcinomas (SCC) with IC50 of 4 nM in UT-SCC-19A cells. |
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S6854新 |
TriazavirinTriazavirin (TZV, Riamilovir) is a novel antiviral drug, a nucleoside analogue of nucleic acid that inhibits the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin is active against influenza and a number of other viruses. Triazavirin is an effective protective agent on the transmission stage of influenza. |
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S1237 |
TemozolomideTemozolomide (CCRG81045, NSC 362856, TMZ) is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. A DNA damage inducer in L-1210 and L-1210/BCNU cells. Temozolomide induces apoptosis and exhibits antitumor activity. |
![]() ![]() C57BL/6 mice were implanted in the striatum with citrine-GL26-Cherry-HMGB1, which were stably transfected to express the YFP citrine and HMGB1 fused to red fluorescent protein cherry. Fourteen days later, they were treated with saline, Ad-TK+Ad-Flt3L, or Ad-TK+Ad-Flt3L+TMZ (temozolomide). Five days after treatment, the cellular location of cherry-HMGB1 in these cells was assessed by confocal microscopy. Arrows, tumor cells (green) with cytoplasmic HMGB1 (red).
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S1212 |
Bendamustine HClBendamustine (SDX-105, Cytostasane) HCl is a DNA-damaging agent with IC50 of 50 μM in cell-free assay. |
![]() ![]() Fractional Analysis of Combination Therapy of SGI-1776 With Bendamustine in B-Cell Lymphoma.
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S1840 |
LomustineLomustine (nsc79037, Gleostine, CeeNU, CCNU) inhibits cancer cells by damaging the DNA and stops cells from dividing. |
![]() ![]() Initial range finding concentration response analysis of the cytotoxic effects of (A) lomustine (IC50 = 12 μM) and (B) vincristine (IC50 = 1.5 nM) on D283 Med in a clonogenic assay of cell survival |
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S7918 |
Bromodeoxyuridine (BrdU)Bromodeoxyuridine (BrdU) is a nucleoside analog that competes with thymidine for incorporation into DNA, and used in the detection of proliferating cells. |
![]() ![]() Immunofluorescence microphotographs of proliferating ARPE-19 cell with BrdU (red) and DAPI (blue) staining after ARPE-19 cells were untreated or treated with AF (1.0 μM) in the absence or presence of EGF (100ng/ml) for 24 hours and then subjected to BrdU labeling for 4 hours, followed by immunostaining with anti-BrdU antibody and DAPI. Scale bar = 20μm.
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S4888 |
GuanineGuanine is one of the four main nucleobases found in the nucleic acids DNA and RNA. |
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S5505 |
2’-deoxyuridine2'-deoxyuridine (dU, 2'-dU) is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms. |
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S6359 |
PurinePurine is a heterocyclic aromatic organic compound which plays crucial roles in DNA and RNA. It is also significant components in a number of other important biomolecules, such as ATP, GTP, cyclic AMP, NADH, and coenzyme A. |
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S4194 |
Azaguanine-8Azaguanine-8 (NSC-749, SF-337, SK 1150) is a purine analogs showing antineoplastic activity by competing with guanine in the metabolism. |
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S4803 |
ThymidineThymidine (Deoxythymidine, 2'-Deoxythymidine, 5-Methyldeoxyuridine) is a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose. As a constituent of DNA, thymidine pairs with adenine in the DNA double helix. |
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S1981 |
AdenineAdenine is a purine derivative and a nucleobase with a variety of roles in biochemistry. |
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S1983 |
Adenine HClAdenine HCl is a hydrochloride salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry. |
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S1982 |
Adenine sulfateAdenine sulfate is a sulfate salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry. |
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S6077 |
Cytidine 5′-triphosphate (disodium salt)Cytidine 5'-triphosphate is a pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions. It is used in the synthesis of RNA by RNA polymerases. |
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S5374 |
5'-Cytidylic acid5'-Cytidylic acid (Cytidine monophosphate, Cytidine 5'-phosphate) is a nucleotide that is used as a monomer in RNA. |
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S5384 |
UTP Trisodium SaltUridine-5'-triphosphate (UTP) is a pyrimidine nucleoside triphosphate and a substrate for the synthesis of RNA during transcription. |
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S3190 |
N6-methyladenosine (m6A)N6-methyladenosine (m6A, NSC-29409) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs. |
![]() ![]() (A) Comparison of ribose modification across the RNA species. Modified nucleosides of MRC-5 cells were aligned in terms of modification type and then RNA species. Data are presented as means ± STD, n = 3. (B) tRNA modification profiles of cancer tissues. Data are presented as means ± STD, n = 5. |
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S2029 |
UridineUridine (NSC 20256) is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond. |
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S9382 |
ThymineThymine (5-methyluracil) is one of the four nucleobases in the nucleic acid of DNA. |
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
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S1166 |
CisplatinCisplatin (cisplatinum, cis-diamminedichloroplatinum II, CDDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. Cisplatin activates ferroptosis and induces autophagy. Solutions are best fresh-prepared. |
![]() ![]() Cell viabilities with increasing concentrations of cisplatin (CP) and doxorubicin (DOXO) under normoxic and hypoxic condition for 48 hours were determined by MTT assay. IC50 values are presented as the means ?SDs (n=4) and * denotes p<0.05. |
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S1149 |
Gemcitabine HClGemcitabine HCl (LY188011) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. |
![]() ![]() RNA incorporating drugs induce SG assembly. HeLa cells were treated with the RNA incorporating agents 5-azacytidine (50 uM) and 6-thioguanine (10 uM), or the DNA incorporating agents trifluorothymidine (10 uM) and gemcitabine (100 nM) for 72 h. Subsequently, the cellular localization of the SG marker protein TIAR (green) and the P-body marker protein DCP1 (red) was analyzed. Nuclei were stained with Hoechst. Scale bars represent 20 um. |
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S1135 |
PemetrexedPemetrexed (LY-231514) is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis. |
![]() ![]() Role of PARP and BER in the synergy between PTX and GMX in A549 cells. Cells were pretreated ±1 umol/L olaparib (2 hours) then sequentially ±150 nmol/L PTX (24 hours), then ± GMX 12 nmol/L (48 hours). PAR modification of proteins and γ-H2AX levels were measured in extracts treated as in A by Western blotting.
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S1215 |
CarboplatinCarboplatin (JM-8, CBDCA, NSC 241240) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. Solutions are best fresh-prepared. |
![]() ![]() Detection of apoptotic responses was found to increase in epimorphin-treated A1847 with increasing concentrations of carboplatin compared to those of the untreated controls. Data were normalized to the controls and are represented as means ± S.D. [*p<0.05 compared with control]. Images of apoptotic cells were captured at 10X magnification, with at least 3 images per well, using an upright phase-contrast microscope (T3.15A; Fisher Scientific). |
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S3360新 |
Bis(2-ethylhexyl) phthalateBis(2-ethylhexyl) phthalate (Dioctyl phthalate, DOP, Diplast O, ESBO-D 82, Ergoplast FDO, Ergoplast FDO-S, Etalon) induces DNA strand breaks and gene expression alterations in larval zebrafish Danio rerio. |
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S3356新 |
Phosphonoacetic acidPhosphonoacetic acid (PAA) is an active endogenous metabolite that possesses a restricted potential to block DNA biosynthesis. Phosphonoacetic acid exhibits anti-viral activities. |
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S3009新 |
MenthoneMenthone is one of the main volatile components of the essential oil of peppermint (Mentha piperita L.). Menthone is used as antioxidant agent and has a good compensatory effect with significant reduction in DNA damages in sperm cells. |
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S9718新 |
TK216TK216 is a potent inhibitor targeting E26 transformation specific (ETS) factors via blocking the protein-protein interaction with RNA helicases. TK216 exhibits antilymphoma activity. |
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S9649新 |
Acelarin (NUC-1031)Acelarin (NUC-1031, Fosgemcitabine palabenamide, CPF-31, MTL-007, GTPL7389), a prodrug based on an aryloxy phosphoramidate derivative of gemcitabine, is a DNA synthesis inhibitor with EC50 of 0.2 nM. |
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S8977新 |
BCH001BCH001 is a specific PAPD5 inhibitor that restores telomerase activity and telomere length in dyskeratosis congenita (DC) patient induced pluripotent stem cells. PAPD5 is a noncanonical poly(A) polymerase with an unusual RNA-binding motif. |
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S8850新 |
JH-RE-06JH-RE-06 is a potent REV1-REV7 interface inhibitor with an IC50 of 0.78 μM and Kd value of 0.42 μM, disrupting REV1-POL ζ-mediated mutagenic translesion synthesis (TLS). |
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S7418新 |
CycloheximideCycloheximide (Actidione, Naramycin A, CHX), an antifungal antibiotic, is an eukaryote protein synthesis inhibitor with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively. Cycloheximide suppresses ferroptosis and inhibits autophagy. |
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S6848新 |
3'-Fluoro-3'-deoxythymidine (Alovudine)3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer. |
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S0816新 |
Brr2 Inhibitor C9Brr2 inhibitor C9 (Brr2 Inhibitor 9) is an allosteric inhibitor of the spliceosomal RNA helicase Brr2. Brr2 is implicated in autosomal-dominant retinitis pigmentosa a group of progressive retinal degenerative disorders. |
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S0780新 |
Oncrasin-1Oncrasin-1 (Onc-1) is a potent RNA polymerase II inhibitor with antitumor activity that kills various human lung cancer cells with K-Ras mutations. Oncrasin-1 drives abnormal aggregation of protein kinase C iota (PKCι) in nucleus of sensitive cells but not in resistant cells. |
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S0469新 |
ML216ML216 (CID-49852229) is a potent and selective inhibitor of the DNA unwinding activity of BLM(Bloom’s syndrome protein) with antitumor activity. ML216 inhibits helicases with IC50 of 0.97 μM and 2.98 μM for BLM636-1298 and BLMfull-length, respectively. |
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S0280新 |
MadrasinMadrasin (DDD00107587) is a potent and cell-penetrant pre-mRNA splicing inhibitor. Madrasin interferes with the early stages of spliceosome assembly and stalls spliceosome assembly at the A complex. |
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S0102新 |
L 189L 189 is a novel human DNA ligase inhibitor with IC50 of 5 μM, 9 μM and 5 μM for hLigI, hLigIII and hLigIV, respectively. L 189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L 189 specifically sensitizes cancer cells to DNA damage. |
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S0063新 |
RG3039RG3039 (PF-06687859, PF 6687859, Quinazoline 495) is an orally bioavailable and brain-penetrant inhibitor of the mRNA decapping enzyme DcpS with IC50 of 4.2 nM and IC90 of 40 nM, respectively. |
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S0054新 |
D-I03D-I03 is a selective inhibitor of RAD52 with Kd of 25.8 µM. D-I03 inhibits ssDNA annealing by RAD52 and D-loop formation with IC50 of 5 µM and 8 µM, respectively. |
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S2600新 |
FexinidazoleFexinidazole (HOE-239, Fexinidazole Winthrop) is a 5-nitroimidazole derivative. Fexinidazole is a DNA synthesis inhibitor and the only, all-oral agent for Human African Trypanosomiasis(HAT or sleeping sickness). |
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S8932新 |
Remdesivir (GS-5734)Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV. |
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S1491 |
FludarabineFludarabine (FaraA, Fludarabinum) is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis. |
![]() ![]() Normal human KC pretreated with STAT1 inhibitor (fludarabine [10 uM]) or STAT3 inhibitor (STA-21 [2 uM]) for 24 h. The mRNA levels of hBD2 and hBD3 were assessed by qRT-PCR.
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S1224 |
OxaliplatinOxaliplatin (L-OHP) is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells. DMF is recommended for dissolution. Solutions are best fresh-prepared. |
![]() ![]() Immunocytochemical staining of SW620 (metastatic) cells after treatment with 10 uM oxaliplatin (F) or 10 uM ginsenosides 20(S)-Rg 3 (G) and negative staining (H). Cells demonstrated differential expression of histone H4. |
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S2684 |
CX-5461CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116, A375, and MIA PaCa-2 cells, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation. |
![]() ![]() The specific Pol I inhibitor CX-5461 causes nucleolar disruption, blocks LTP maintenance and Fsk-induced synthesis of new rRNA. DAPI staining (blue; A, B,C) shows the area of the nucleus. Nomarski images (grey; G, H,I) show the area of the nuclei and nucleoli (arrowheads). Application of Pol I specific inhibitor CX-5461 (200 nM) causes nucleolar disruption as indicated by the distribution of fibrillarin (green); compare A, D to B, E and C, F.
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S1209 |
Fluorouracil (5-Fluorouracil, 5-FU)Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV. |
![]() ![]() DNA-PKcs suppression mediated ROS production and GSH content in HepG2 cells exposed to CDDP and 5-Fu. a DNA-PKcs inhibition promoted ROS production in HepG2 cells treated with indicated concentrations of CDDP and 5-Fu. DCFH-DA fluorescent analysis was performed to assess the ROS level. Data presented were mean ?SD of three independent experiments.
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S1156 |
CapecitabineCapecitabine (RO 09-1978) is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU. Capecitabine treatment of HCT-15 cells causes condensation of DNA and induces apoptosis. |
![]() ![]() Growth curve of human colon cancer xenografts in nude mice treated with orally administered vehicle or capecitabine at 360 mg/kg (n = 10–12 per cell line). |
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S1229 |
Fludarabine PhosphateFludarabine Phosphate (F-ara-A, NSC 312887) is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis. |
![]() ![]() Imatinib mesylate (IM) in combination of F-AMP significantly inhibits Ki67 and c-KIT expression in GIST-T1 tumor xenografts. Tumors were collected on the day after the last treatment and were then subjected to H&E staining and immunohistochemical detection of Ki67, c-KIT, and cleaved caspase-3 expression. Representative images of H&E staining and immunohistochemical staining of Ki67, c-KIT, and cleaved caspase-3 in mice tumors. Arrows indicate the decrease in cellularity and the increase in stromal fibrosis. Magnification, x 400.
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S1117 |
TriciribineTriciribine (NSC 154020, VD-0002, vqd-002, API-2) is a DNA synthesis inhibitor, also inhibits Akt in PC3 cell line and HIV-1 in CEM-SS, H9, H9IIIB, U1 cells with IC50 of 130 nM and 20 nM, respectively; does not inhibit PI3K/PDK1; 5000-fold less active in cells lacking adenosine kinase. Phase 1/2. |
![]() ![]() Effect of triciribine on the migration of (A) FaDu and (B) Hep2 cells. The cells were treated with 5 µM triciribine for different periods of time. *P<0.05 vs. control. Hpf, high-power field. |
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S1516 |
CidofovirCidofovir (HPMPC) suppresses virus replication by selective inhibition of viral DNA synthesis. |
![]() ![]() The copy numbers of the intracellular viral DNA were directly extracted from cells and were quantified by qPCR using primers specific for the KSHV ORF73 gene. Then each sample was normalized to the amount of the GAPDH gene (C), CDV (20 µM) was used as a positive control. CDV:Cidofovir. |
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S1648 |
CytarabineCytarabine (Cytarabin, Ara-C, Arabinofuranosyl Cytidine) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. Cytarabine induces autophagy and apoptosis. |
![]() ![]() Viability and CI vs Fa after 24-h exposure to cytarabine alone or in combination with ABT-199 in Riva, U2932 and VavP-Bcl2/c-MYC murine tumor cells. Viability shown at 500 nM (500 ng/ml for cytarabine; quadruplicates±s.e.m.).
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S1714 |
GemcitabineGemcitabine (LY-188011, NSC 613327), a nucleic acid synthesis inhibitor, is a very potent and specific deoxycytidine analogue, used as chemotherapy. Gemcitabine induces a potent p53-dependent apoptosis. |
![]() ![]() RNA incorporating drugs induce SG assembly. HeLa cells were treated with the RNA incorporating agents 5-azacytidine (50 uM) and 6-thioguanine (10 uM), or the DNA incorporating agents trifluorothymidine (10 uM) and gemcitabine (100 nM) for 72 h. Subsequently, the cellular localization of the SG marker protein TIAR (green) and the P-body marker protein DCP1 (red) was analyzed. Nuclei were stained with Hoechst. Scale bars represent 20 um. |
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S1213 |
NelarabineNelarabine (506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells. |
![]() ![]() b) Western blot analysis documenting cleavage of caspase-8, caspase-9, caspase-3, and PARP by nelarabine. Cells were treated with nelarabine (5 μM for JURKAT, P12-ICHIKAWA, and DND-41 cells, 2 μM MOLT-4 cells) for the indicated times, collected, and then lysed. Fifty micrograms of each lysate were electrophoresed on SDS-PAGE gels followed by transfer onto a nitrocellulose membrane. c) Nelarabine induces a decrease in the phosphorylation status of critical components of the PI3K/AKT/mTOR signaling pathway, as well as p-ERK (Thr202) levels in T-ALL sensitive cell lines. Western blot analysis documenting the reduction of p-AKT (Ser473), p-S6RP, p-GSK3β (Ser9), and p-ERK (Thr202). Antibody to β-actin served as a loading control. Molecular weights are indicated on the right
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S1373 |
DaptomycinDaptomycin (LY146032) is a novel antibiotic with rapid in vitro bactericidal activity against gram-positive organisms. |
![]() ![]() Same experiment as in Figure 2 with fluorescent daptomycin shown as confocal images. A 7/3 DOPC/DOPG GUV (including 1% Rh-PE) was introduced at time zero into a solution containing 1 uM daptomycin with 0.5 uM BODIPY-daptomycin and 1 mM Ca2+. To show colocalization of lipid and peptide in aggregates, confocal images were taken: red for RH-PE and green for BODIPY-daptomycin. As the protrusion length decreased, aggregates appeared on the GUV surface containing both lipid and peptide. The scale bar is 10 um.
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S3035 |
Daunorubicin HClDaunorubicin HCl (Daunomycin) inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay. Daunorubicin is a topoisomerase II inhibitor that induces apoptosis. |
![]() ![]() A) MV411 or B) Kasumi 1 cells were incubated with YM155 (0.25 x IC50) in the presence or absence of i) 0.5 x IC50 or ii) 1 x IC50 of Daunorubicin or iii) 0.5 x IC50 or iv) 1 x IC50 of Cytarabine for 72h. Following 72h treatment, cells were subject to a resazurin reduction assay. Percentages were normalised to DMSO controls. Column, mean of 3 independent experiments; Bars, SEM. *p<0.05, **p<0.01, ***p<0.005. Students t-test. Similar trends were observed with 0.5 x and 1 x IC50 of YM155 in combination with Daunorubicin or Cytarabine (data not shown). |
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S1199 |
CladribineCladribine (2-CdA, 2-chlorodeoxyadenosine) is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively. |
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S1192 |
RaltitrexedRaltitrexed (ZD-1694) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth. |
![]() ![]() Fig. 1. Raltitrexed dose-response curve. HEK293 parental and MRP5 transfected cells were plated in a 96-well plate at a density of 4000 cells/well in complete DMEM (10% FBS, 1% Pencillin/streptomycin) and allowed to incubate for 24h at 37°C, 5% CO2. Raltirexed was added and the cells allowed to incubate for 72h. Total DNA present in each well was then quantified using Cyquant® cell proliferation assay. Results show Total DNA as % of the DMSO-only control wells. Experiment was done in triplicate. |
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S1218 |
ClofarabineClofarabine inhibits the enzymatic activities of ribonucleotide reductase (RNR) (IC50 = 65 nM) and DNA polymerase. Clofarabine induces autophagy and apoptosis. |
![]() ![]() Immunoblot analysis of cell lysates of NCI-H929 cells treated with CLO (5 μM, 3-48 h) GAPDH served as the loading control for each membrane, and data are representative of at least two independent experiments |
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S1302 |
IfosfamideIfosfamide (NSC109724, Isophosphamide) is a nitrogen mustard alkylating agent used in the treatment of cancer. |
![]() ![]() Chemotherapeutic response. Ifosfamide was applied at different concentrations on Lipo-DUE1, Lipo246, and PLS-1 for 72 h. Subsequently, cell viability was determined by MTS assay at a wavelength of 490 nm. Values represent the mean±S.D. of triplicates
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S2678 |
NSC 207895NSC 207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase. |
![]() ![]() Median overall survival of mice (n = 5 mice in vehicle and PYR-41; n = 4 mice in NSC group) inoculated with IOWA-1T xenografts were increased to 43 ± 0.5 and 39 ± 2 days with PYR-41 (PYR) and NSC-207895 (NSC), respectively, compared with a vehicle-treated control group 33 ± 1 days (*p < 0.05).
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S1221 |
DacarbazineDacarbazine (DTIC-Dome) is a triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis; used in the treatment of various cancers. |
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S1896 |
HydroxyureaHydroxyurea (nci-c04831, nsc32065) is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. Hydroxyurea activates apoptosis and autophagy. Hydroxyurea is used to treat HIV infection. |
![]() ![]() Lethally irradiated C57BL/6 recipient mice were injected with a 1:1 mixture of GFP+JAK2(V671F) and wild-type bone marrow cells. Five weeks later, mice were treated with vehicle (C), hydroxyurea (H; 30 mg/kg twice daily IP), ruxolitinib (R; 30 mg/kg twice daily oral gavage), BMN673 (B; 0.33 mg/kg IV), H+R, H+B, R+B, and H+R+B for 3 weeks. Percentage of GFP+JAK2(V617F) was measured in (panel B) bone marrow cells, (panel C) splenocytes, and (panel D) peripheral blood leukocytes; (panel E) number of GFP+JAK2(V617F) Lin−Sca1+c-Kit+ (LSK) cells per 106 bone marrow cells was calculated, too. *P < .05, **P < .05, and ***P < .05 when compared with control, single treatment, and double treatment, respectively, from 6 to 7 mice using the Student t test.
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S1807 |
AciclovirAcyclovir (Acyclovir, Acycloguanosine, Zovirax) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells. |
![]() ![]() (A) HONE1 and (B) HK1-EBV cells were treated with TPA (40 ng/ml) and SB (3 mM) for EBV induction. After 3 h, uninduced and induced HONE1 and HK1-EBV cells were treated with the vehicle control (0.006% DMSO) or indicated concentrations of berberine for 48 h. Subsequently, the culture medium was harvested for quantitative-PCR analysis with EBNA1 primers. Each sample was normalized to the amount of the GAPDH gene; *p<0.05, compared with the control group.
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S1299 |
FloxuridineFloxuridine (Deoxyfluorouridine, FUDR, NSC 27640) is an antineoplastic antimetabolite, used in the treatment of colon carcinoma and colorectal cancer that has metastasized to the liver. |
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S1305 |
Mercaptopurine (6-MP)Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. |
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S1384 |
MizoribineMizoribine (Bredinin, NSC 289637) is an imidazole nucleoside and an immunosuppressant that inhibits HCV RNA replication with IC50 of ~ 100 μM for anti-HCV activity. Mizoribine is a selective inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH) and guanosine monophosphate synthetase. Mizoribine also inhibits SARS-CoV. |
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S1949 |
MenadioneMenadione(Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement. |
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S2239 |
TubacinTubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1. Tubacin reduces the replication of the Japanese Encephalitis Virus via the decrease of viral RNA synthesis. |
![]() ![]() Verification of Hdac6 deletion in knockout MEFs. Expression of HDAC6 and acetylation of tubulin were analyzed by immunoblotting.
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S1289 |
CarmofurCarmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. |
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S4227 |
FidaxomicinFidaxomicin (OPT-80, PAR-101) is a narrow spectrum macrocyclic antibiotic that inhibits RNA polymerase sigma subunit. |
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S1907 |
MetronidazoleMetronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa. |
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S1760 |
RifapentineRifapentine (MDL473) is an antibiotic, which inhibits DNA-dependent RNA polymerase activity, used to treat tuberculosis. |
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S1778 |
TrifluridineTrifluridine (NSC 529182, NSC 75520) is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye. |
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S1790 |
RifaximinRifaximin is a RNA synthesis inhibitor by binding the β subunit of the bacterial DNA-dependent RNA polymerase, used to treat traveler's diarrhea caused by certain bacteria. |
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S1995 |
Procarbazine HClProcarbazine HCl (NSC-77213) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound, used for the treatment of Hodgkin's lymphoma. |
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S1784 |
VidarabineVidarabine is an antiviral drug by interfering with the synthesis of viral DNA, used to treat herpes simplex and varicella zoster viruses. |
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S1764 |
RifampinRifampin (Rimactane, Rifampicin) is a DNA-dependent RNA polymerase inhibitor, used to treat a number of bacterial infections. |
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S3001 |
ClevudineClevudine is an antiviral drug for the treatment of hepatitis B. |
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S1300 |
Tegafur (FT-207)Tegafur (FT-207, NSC 148958) is a substance being used in the treatment of some types of cancer. |
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S1826 |
NedaplatinNedaplatin is a derivative of cisplatin and DNA damage agent for tumor colony forming units with IC50 of 94 μM. |
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S7470 |
TriapineTriapine (3-AP) is a potent ribonucleotide reductase (RNR) inhibitor with broad spectrum antitumor activity by inhibiting DNA synthesis. Phase 2. |
![]() ![]() (a) Quantification of p-RPA/ Rad51, 53BP1 and γH2AX in GBM01 cells treated with DMSO or triapine. (b) Quantification of p-RPA/Rad51, 53BP1 and γH2AX in GBM02 cells treated with DMSO or triapine.
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S7757 |
6-Thio-dG6-thio-dG is a nucleoside analog and telomerase substrate. |
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S4297 |
MupirocinMupirocin is an isoleucyl t-RNA synthetase inhibitor, used in the treatment of bacterial skin infections. |
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S8376 |
Rbin-1Rbin-1 (Ribozinoindole-1) is a potent chemical inhibitor of eukaryotic ribosome assembly. It inhibits recombinant full-length Mdn1's ATPase activity in vitro. |
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S9521 |
PentostatinPentostatin is a potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. |
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S5552 |
AmenamevirAmenamevir (ASP2151) is a potent helicase-primase inhibitor and a novel class of antiviral agent. |
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S8095 |
TubercidinTubercidin (7-deaza-adenosine), an adenosine analogue, is a nucleoside antibiotic. It is incorporated into DNA and inhibits polymerases, thereby inhibiting DNA replication and RNA and protein synthesis. This agent also exhibits antifungal and antiviral activities. |
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S4035 |
Vitamin D2Vitamin D2 (Ergocalciferol) is a selective inhibitor of mammalian DNA polymerase A (pol A) with IC50 of 123 μM. |
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S7975 |
Favipiravir (T-705)Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections. |
![]() ![]() (A) BoDV-1 infection was measured by IFA. BoDV-1 P40 was detected with a primary monoclonal antibody (red), nuclei were stained with DAPI (blue), merged image (scale bars: 50 μm). Favipiravir: T-705
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S8328 |
CeMMEC1 HClCeMMEC1 is an N-methylisoquinolinone derivative that inhibits the second bromodomain of TAF1 (IC50=0.9 μM). |
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S5484 |
Rimantadine HydrochlorideRimantadine is an RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza. It works by inhibiting a viral protein called M2, which normally mediates the transport of acid ions across the influenza virion shell. |
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S4504 |
6-Mercaptopurine (6-MP) Monohydrate6-Mercaptopurine (6-MP) Monohydrate is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. |
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S7742 |
SCR7SCR7 is a specific DNA Ligase IV inhibitor, which blocks nonhomologous end-joining (NHEJ). |
![]() ![]() The start codon CUG of PTEN-long was mutated to AUG and PTENlong expression is significantly increased. gRNA1 and gRNA2 have similar efficiency in driving PTEN-long expression (lanes 1 and 2). Combined gRNA1 and gRNA2 (lane 3) did not enhance PTEN-long expression compared to lane 1 and 2. The ssODN is required for mutation of CTG to ATG through HDR and without which PTEN-long is not expressed (lane 4). PTEN-long cDNA cloned into pcDNA3.1 with CTG to ATG mutation was highly expressed in transfected HEK293T cells (lane 5). Lane 6 is protein ladder. Lanes 7–10 indicate that the combination of gRNA and ssODN is required to facilitate HDR occurrence and double-strand DNA break. |
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S4737 |
PsoralenPsoralen (Psoralene, Ficusin, Furocoumarin) is a naturally occurring furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division. |
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S8146 |
Mitomycin CMitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner. |
![]() ![]() MTT results of three HCC cell lines at 72 h after indicated treatments. Three independent experiments were carried out.
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S1973 |
Cyclocytidine HClCyclocytidine (NSC 145668) is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia. |
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S3641 |
OsalmidOsalmid suppresses ribonucleotide reductase (RR) activity in a concentration-dependent manner, with a 50% RR activity-inhibitory concentration (IC50) of 8.23 μM. |
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S7449 |
CRT0044876CRT0044876 (NSC 69877, 7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM. |
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S7445 |
E3330E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity. |
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S5293 |
Nimustine HydrochlorideNimustine Hydrochloride (Nidran) is the hydrochloride salt of nimustine, a nitrosourea with antineoplastic activity that alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death. |
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S5297 |
Vidarabine monohydrateVidarabine (Spongoadenosine, Vira-A) is a nucleoside antibiotic with antiviral acitivity that interferes with the synthesis of viral DNA. It is used to treat herpes simplex and varicella zoster viruses. |
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S2794 |
Sofosbuvir (GS-7977)Sofosbuvir (PSI-7977, GS-7977) is a HCV NS5B polymerase inhibitor for the treatment of chronic hepatitis C virus (HCV) infection. |
![]() ![]() Representative confocal microscope image showing phosphorylated Drp1 translocation to mitochondria and mitochondrial fission in the presence of Sofosbuvir. At 24 hours after treatment with Sofosbuvir (100 nM), Huh7 cells were immunostained with antibodies against TOM20 (red) and p-Drp1 (S616) (green). Nuclei are demarcated with white dotted circles. Treated (+) and untreated (–) cells are marked. In the zoomed images, the arrows indicate the colocalization of TOM20 and p-Drp1 (S616) in Sofosbuvir-treated cells (yellow spots).
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S6115 |
Pyridoxal 5′-phosphate hydratePyridoxal 5′-phosphate (pyridoxal phosphate, Vitamin B6 phosphate, PAL-P, PLP), a vitamin B6 phosphate, is a coenzyme in a variety of enzymatic reactions. |
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S8434 |
B02B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM). |
![]() ![]() HEK 293T cells were transfected with a total of 6 μg of plasmid DNA (2 μg pSG-I-SceI-HA, 2 μg pcDNA-HBZ-Myc-His or empty vector, and 2 μg the pDR-GFP reporter) and treated with 20 μM B02 for 48 h where indicated. Data shown are averages of results from three independent experiments, and error bars represent SEM (*, P ≤ 0.05 by Student's t test).
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S8539 |
TAS-102TAS-102 is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride. |
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S7637 |
DTP3DTP3 is a selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor and is able to restore MKK7/JNK activation. DTP3 inhibits cancer-selective NF-κB survival pathway. |
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S8144 |
HalofuginoneHalofuginone is the competitively inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in mammal. |
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S3669 |
CarmustineCarmustine (bis-chloroethylnitrosourea, BCNU, BiCNU) is a cell-cycle phase nonspecific alkylating antineoplastic agent and used in the treatment of brain tumors and various other malignant neoplasms. |
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S7679 |
YK-4-279YK-4-279 is a potent inhibitor of EWS-FLI1 binding to RNA helicase A (RHA). |
![]() ![]() YK-4-279-induced cell apoptosis of NB cells by Western blot assay. SH-SY5Y cells were treated with YK-4-279 (0, 0.1 μM, 0.3 μM, 1 μM, 3 μM) for 24 h. Whole cell lysates were subjected to SDS-PAGE and immunoblotted with antibodies against PARP and Caspase 3 to detect apoptosis. β-actin was detected as loading control. YK-4-279-induced apoptosis of NB cell line SH-SY5Y by FACS. Cells were treated with YK-4-279 (0, 1 μM, 3 μM) for 24 h, and then stained by PI and analyzed by FACS.
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S4236 |
Proflavine HemisulfateProflavine Hemisulfate is a topical antiseptic by interchelating DNA, thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands. |
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S7718 |
BMH-21BMH-21 is a DNA intercalator, which binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription. |
![]() ![]() Pharmacological and siRNA perturbations in HEK293 cells suggest that mTORC1 also modulates cytoplasmic rheology through ribosome crowding in mammals.
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S4239 |
BergaptenBergapten is a psoralen that can be photoactivated and is capable of crossing-linking DNA, covalently modifying proteins and lipids, and consequently inhibiting cell replication. |
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S4782 |
5-methoxyflavone5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. |
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S4537 |
Oxolinic acidOxolinic acid (Urinox, NSC 110364) is a quinolone antibiotic, inhibiting the enzyme DNA gyrase and DNA synthesis.It also acts as a dopamine reuptake inhibitor. |
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S7546 |
Pritelivir (BAY 57-1293)Pritelivir (BAY 57-1293, AIC316) is a potent helicase primase inhibitor, exhibiting antiviral effect on herpes simplex virus (HSV) with IC50 of 20 nM for both HSV-1 and HSV-2. |
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S8329 |
CeMMEC13CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 µM). |
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S5582 |
Cytarabine hydrochlorideCytarabine is a pyrimidine nucleoside analog that is used mainly in the treatment of leukemia. It is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. |
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S7419 |
Blasticidin S HClBlasticidin S HCl is a nucleoside antibiotic isolated from Stretomyces girseochromogenes, and acts as a DNA and protein synthesis inhibitor, used to select transfected cells carrying bsr or BSD resistance genes. |
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S4288 |
ChloroambucilChloroambucil (Chlorambucil) is a nitrogen mustard alkylating agent, used in the treatment of chronic lymphocytic leukemia. |
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S8246 |
RK-33RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells. |
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
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S3168新 |
cis-Resveratrolcis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. Resveratrol also inhibits a wide spectrum of targets including 5-lipoxygenase (LOX), cyclooxygenase (COX), IKKβ, DNA polymerases α and δ with IC50 of 2.7 μM, <1 μM, 1 μM, 3.3 μM and 5 μM, respectively. |
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S6893新 |
PIN1 inhibitor API-1PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor with IC50 of 72.3 nM. PIN1 inhibitor API-1 targets Pin1 peptidyl-prolyl isomerase domain and inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 up-regulates miRNA biogenesis by retaining active XPO5 conformation and suppresses HCC development. |
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S2427新 |
Triglycidyl Isocyanurate (Teroxirone)Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry. |
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S8326 |
Saccharin 1-methylimidazole (SMI)Saccharin 1-methylimidazole (SMI) is considered a general-purpose activator for DNA and RNA synthesis. |
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
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S1334 |
Flupirtine maleateFlupirtine maleate is the salt form of Flupirtine, which is a centrally acting non-opioid analgesia, is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties. |
2019, 17(7):310-321 |
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
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S9603新 |
LurbinectedinLurbinectedin (PM01183, PM-1183, LY-01017, Tryptamicidin, Zepsyre, ZEPZELCA), a DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity. Lurbinectedin inhibits RMG1 and RMG2 cell growth with IC50 of 1.25 nM and 1.16 nM, respectively. |
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
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S1214 |
Bleomycin SulfateBleomycin Sulfate (NSC125066) is a glycopeptide antibiotic and an anticancer agent for squamous cell carcinomas (SCC) with IC50 of 4 nM in UT-SCC-19A cells. |
2020, 12(530) 2020, 22 pii: S1097-2765(20)30231-8 2020, 29;11(1):2086 |
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S6854新 |
TriazavirinTriazavirin (TZV, Riamilovir) is a novel antiviral drug, a nucleoside analogue of nucleic acid that inhibits the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin is active against influenza and a number of other viruses. Triazavirin is an effective protective agent on the transmission stage of influenza. |
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S1237 |
TemozolomideTemozolomide (CCRG81045, NSC 362856, TMZ) is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. A DNA damage inducer in L-1210 and L-1210/BCNU cells. Temozolomide induces apoptosis and exhibits antitumor activity. |
2021, 11(4):1991-2005 2021, ddab009 2021, 21(2):175 |
![]() ![]() C57BL/6 mice were implanted in the striatum with citrine-GL26-Cherry-HMGB1, which were stably transfected to express the YFP citrine and HMGB1 fused to red fluorescent protein cherry. Fourteen days later, they were treated with saline, Ad-TK+Ad-Flt3L, or Ad-TK+Ad-Flt3L+TMZ (temozolomide). Five days after treatment, the cellular location of cherry-HMGB1 in these cells was assessed by confocal microscopy. Arrows, tumor cells (green) with cytoplasmic HMGB1 (red).
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S1212 |
Bendamustine HClBendamustine (SDX-105, Cytostasane) HCl is a DNA-damaging agent with IC50 of 50 μM in cell-free assay. |
2020, 30;9(1):1758011 2020, 19;20:58 2020, 10.1007/s13577-020-00420-z |
![]() ![]() Fractional Analysis of Combination Therapy of SGI-1776 With Bendamustine in B-Cell Lymphoma.
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S1840 |
LomustineLomustine (nsc79037, Gleostine, CeeNU, CCNU) inhibits cancer cells by damaging the DNA and stops cells from dividing. |
2020, 580(7804):517-523. 2020, 19;20:58 2020, 10.1111/vco.12656 |
![]() ![]() Initial range finding concentration response analysis of the cytotoxic effects of (A) lomustine (IC50 = 12 μM) and (B) vincristine (IC50 = 1.5 nM) on D283 Med in a clonogenic assay of cell survival |
S7918 |
Bromodeoxyuridine (BrdU)Bromodeoxyuridine (BrdU) is a nucleoside analog that competes with thymidine for incorporation into DNA, and used in the detection of proliferating cells. |
2020, 28;e12818 2019, 109:1951-1959 2018, 10.1016/j.biopha.2018.11.029 |
![]() ![]() Immunofluorescence microphotographs of proliferating ARPE-19 cell with BrdU (red) and DAPI (blue) staining after ARPE-19 cells were untreated or treated with AF (1.0 μM) in the absence or presence of EGF (100ng/ml) for 24 hours and then subjected to BrdU labeling for 4 hours, followed by immunostaining with anti-BrdU antibody and DAPI. Scale bar = 20μm.
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S4888 |
GuanineGuanine is one of the four main nucleobases found in the nucleic acids DNA and RNA. |
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S5505 |
2’-deoxyuridine2'-deoxyuridine (dU, 2'-dU) is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms. |
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S6359 |
PurinePurine is a heterocyclic aromatic organic compound which plays crucial roles in DNA and RNA. It is also significant components in a number of other important biomolecules, such as ATP, GTP, cyclic AMP, NADH, and coenzyme A. |
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S4194 |
Azaguanine-8Azaguanine-8 (NSC-749, SF-337, SK 1150) is a purine analogs showing antineoplastic activity by competing with guanine in the metabolism. |
2020, 19;20:58 2020, 10.1007/s13577-020-00420-z 2020, 10.1007/s13577-020-00425-8 |
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S4803 |
ThymidineThymidine (Deoxythymidine, 2'-Deoxythymidine, 5-Methyldeoxyuridine) is a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose. As a constituent of DNA, thymidine pairs with adenine in the DNA double helix. |
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S1981 |
AdenineAdenine is a purine derivative and a nucleobase with a variety of roles in biochemistry. |
2020, 16;16(3):e1008341 |
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S1983 |
Adenine HClAdenine HCl is a hydrochloride salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry. |
2020, 19;20:58 2020, 10.1007/s13577-020-00420-z 2020, 10.1007/s13577-020-00425-8 |
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S1982 |
Adenine sulfateAdenine sulfate is a sulfate salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry. |
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S6077 |
Cytidine 5′-triphosphate (disodium salt)Cytidine 5'-triphosphate is a pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions. It is used in the synthesis of RNA by RNA polymerases. |
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S5374 |
5'-Cytidylic acid5'-Cytidylic acid (Cytidine monophosphate, Cytidine 5'-phosphate) is a nucleotide that is used as a monomer in RNA. |
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S5384 |
UTP Trisodium SaltUridine-5'-triphosphate (UTP) is a pyrimidine nucleoside triphosphate and a substrate for the synthesis of RNA during transcription. |
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S3190 |
N6-methyladenosine (m6A)N6-methyladenosine (m6A, NSC-29409) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs. |
2020, 10.1038/s41588-020-0677-3 2019, 21(5):651-661 2019, 10(1):5126 |
![]() ![]() (A) Comparison of ribose modification across the RNA species. Modified nucleosides of MRC-5 cells were aligned in terms of modification type and then RNA species. Data are presented as means ± STD, n = 3. (B) tRNA modification profiles of cancer tissues. Data are presented as means ± STD, n = 5. |
S2029 |
UridineUridine (NSC 20256) is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond. |
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S9382 |
ThymineThymine (5-methyluracil) is one of the four nucleobases in the nucleic acid of DNA. |