DNA/RNA合成

シグナル伝達経路

研究分野

阻害剤の選択性比較
溶解度

カタログ番号	製品カタログ	溶解度(25°C)
カタログ番号	製品カタログ	水	DMSO	アルコール
S1149	Gemcitabine HCl	19 mg/mL	<1 mg/mL	<1 mg/mL
S1135	Pemetrexed	94 mg/mL	<1 mg/mL	<1 mg/mL
S1215	Carboplatin	14 mg/mL	<1 mg/mL	<1 mg/mL
S5582	Cytarabine hydrochloride	-1 mg/mL	55 mg/mL	-1 mg/mL
S5293	Nimustine Hydrochloride	-1 mg/mL	61 mg/mL	-1 mg/mL
S5297	Vidarabine monohydrate	-1 mg/mL	57 mg/mL	-1 mg/mL
S5484	Rimantadine Hydrochloride	-1 mg/mL	43 mg/mL	-1 mg/mL
S4782	5-methoxyflavone	-1 mg/mL	50 mg/mL	-1 mg/mL
S1491	Fludarabine	<1 mg/mL	57 mg/mL	<1 mg/mL
S2684	CX-5461	<1 mg/mL	0.02 mg/mL	<1 mg/mL
S1209	Fluorouracil (5-Fluoracil, 5-FU)	<1 mg/mL	26 mg/mL	<1 mg/mL
S1156	Capecitabine	6 mg/mL	72 mg/mL	72 mg/mL
S1229	Fludarabine Phosphate	2 mg/mL	73 mg/mL	<1 mg/mL
S1516	Cidofovir	12 mg/mL	2 mg/mL	<1 mg/mL
S1648	Cytarabine	48 mg/mL	1 mg/mL	<1 mg/mL
S1714	Gemcitabine	52 mg/mL	52 mg/mL	<1 mg/mL
S1213	Nelarabine	3 mg/mL	60 mg/mL	<1 mg/mL
S1373	Daptomycin	100 mg/mL	100 mg/mL	<1 mg/mL
S1199	Cladribine	<1 mg/mL	57 mg/mL	<1 mg/mL
S1192	Raltitrexed	<1 mg/mL	91 mg/mL	<1 mg/mL
S1218	Clofarabine	<1 mg/mL	60 mg/mL	<1 mg/mL
S1302	Ifosfamide	52 mg/mL	52 mg/mL	52 mg/mL
S2678	NSC 207895	<1 mg/mL	0.4 mg/mL	<1 mg/mL
S1221	Dacarbazine	2 mg/mL	12 mg/mL	1 mg/mL
S1896	Hydroxyurea	15 mg/mL	15 mg/mL	<1 mg/mL
S1299	Floxuridine	49 mg/mL	49 mg/mL	10 mg/mL
S1305	Mercaptopurine (6-MP)	<1 mg/mL	30 mg/mL	<1 mg/mL
S1384	Mizoribine	51 mg/mL	1 mg/mL	<1 mg/mL
S1949	Menadione	<1 mg/mL	34 mg/mL	34 mg/mL
S1289	Carmofur	<1 mg/mL	52 mg/mL	10 mg/mL
S4227	Fidaxomicin	<1 mg/mL	100 mg/mL	<1 mg/mL
S1907	Metronidazole	<1 mg/mL	34 mg/mL	<1 mg/mL
S1760	Rifapentine	<1 mg/mL	100 mg/mL	17 mg/mL
S1778	Trifluridine	59 mg/mL	59 mg/mL	59 mg/mL
S1790	Rifaximin	<1 mg/mL	47 mg/mL	3 mg/mL
S1995	Procarbazine HCl	52 mg/mL	<1 mg/mL	52 mg/mL
S1784	Vidarabine	3 mg/mL	53 mg/mL	<1 mg/mL
S1764	Rifampin	<1 mg/mL	100 mg/mL	<1 mg/mL
S3001	Clevudine	52 mg/mL	52 mg/mL	4 mg/mL
S4252	Mechlorethamine HCl	39 mg/mL	39 mg/mL	39 mg/mL
S1300	Tegafur (FT-207, NSC 148958)	8 mg/mL	40 mg/mL	7 mg/mL
S1826	Nedaplatin	18 mg/mL	<1 mg/mL	<1 mg/mL
S7470	Triapine	<1 mg/mL	20 mg/mL	<1 mg/mL
S7757	6-Thio-dG	<1 mg/mL	56 mg/mL	<1 mg/mL
S4297	Mupirocin	46 mg/mL	100 mg/mL	100 mg/mL
S8376	Rbin-1	<1 mg/mL	23 mg/mL	1 mg/mL
S8095	Tubercidin	<1 mg/mL	53 mg/mL	<1 mg/mL
S4035	Vitamin D2	<1 mg/mL	20 mg/mL	80 mg/mL
S7975	Favipiravir (T-705)	5 mg/mL	31 mg/mL	22 mg/mL
S8328	CeMMEC1 HCl	<1 mg/mL	23 mg/mL	1 mg/mL
S4504	6-Mercaptopurine (6-MP) Monohydrate	<1 mg/mL	34 mg/mL	<1 mg/mL
S7742	SCR7	<1 mg/mL	66 mg/mL	3 mg/mL
S4737	Psoralen	<1 mg/mL	37 mg/mL	<1 mg/mL
S8146	Mitomycin C	<1 mg/mL	66 mg/mL	<1 mg/mL
S1973	Cyclocytidine HCl	44 mg/mL	10 mg/mL	<1 mg/mL
S7449	CRT0044876	<1 mg/mL	41 mg/mL	1 mg/mL
S7445	E3330	<1 mg/mL	75 mg/mL	75 mg/mL
S2794	Sofosbuvir (PSI-7977, GS-7977)	11 mg/mL	100 mg/mL	100 mg/mL
S8434	B02	<1 mg/mL	67 mg/mL	20 mg/mL
S8539	TAS-102	15 mg/mL	100 mg/mL	100 mg/mL
S7679	YK-4-279	<1 mg/mL	73 mg/mL	51 mg/mL
S7718	BMH-21	<1 mg/mL	5 mg/mL	2 mg/mL
S4239	Bergapten	<1 mg/mL	5 mg/mL	<1 mg/mL
S4537	Oxolinic acid	<1 mg/mL	0.5 mg/mL	<1 mg/mL
S7546	Pritelivir (BAY 57-1293)	<1 mg/mL	80 mg/mL	<1 mg/mL
S8329	CeMMEC13	<1 mg/mL	67 mg/mL	6 mg/mL
S4288	Chloroambucil	<1 mg/mL	60 mg/mL	60 mg/mL
S8246	RK-33	<1 mg/mL	85 mg/mL	<1 mg/mL
S8326	Saccharin 1-methylimidazole	53 mg/mL	53 mg/mL	53 mg/mL
S1334	Flupirtine maleate	<1 mg/mL	84 mg/mL	2 mg/mL
S7444	Pyridostatin Trifluoroacetate Salt	100 mg/mL	100 mg/mL	30 mg/mL
S1214	Bleomycin Sulfate	100 mg/mL	100 mg/mL	<1 mg/mL
S9382	Thymine	-1 mg/mL	25 mg/mL	-1 mg/mL
S4888	Guanine	<1 mg/mL	0.1 mg/mL	<1 mg/mL
S5505	2’-deoxyuridine	-1 mg/mL	45 mg/mL	-1 mg/mL
S5374	5'-Cytidylic acid	64 mg/mL	<1 mg/mL	-1 mg/mL
S1237	Temozolomide	<1 mg/mL	38 mg/mL	<1 mg/mL
S1212	Bendamustine HCl	2 mg/mL	78 mg/mL	17 mg/mL
S1840	Lomustine	<1 mg/mL	46 mg/mL	<1 mg/mL
S7918	Bromodeoxyuridine (BrdU)	<1 mg/mL	61 mg/mL	2 mg/mL
S1981	Adenine	<1 mg/mL	<1 mg/mL	<1 mg/mL
S1983	Adenine HCl	4 mg/mL	8 mg/mL	<1 mg/mL
S1982	Adenine sulfate	2 mg/mL	<1 mg/mL	<1 mg/mL
S2029	Uridine	49 mg/mL	49 mg/mL	<1 mg/mL

DNA/RNA Synthesis阻害剤(87)
新DNA/RNA Synthesis製品

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1166	Cisplatin Cisplatin is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells.	Nature, 2017, 546(7656):168-172 Nature, 2017, 552(7683):116-120 Nature, 2017, 545(7654):365-369	Cell viabilities with increasing concentrations of cisplatin (CP) and doxorubicin (DOXO) under normoxic and hypoxic condition for 48 hours were determined by MTT assay. IC50 values are presented as the means ?SDs (n=4) and * denotes p<0.05.
S1149	Gemcitabine HCl Gemcitabine HCl is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.	Sci Transl Med, 2015, 7(284):284ra57 Nucleic Acids Res, 2014, 42(10):6436-47 Clin Cancer Res, 2014, 20(12):3187-97	RNA incorporating drugs induce SG assembly. HeLa cells were treated with the RNA incorporating agents 5-azacytidine (50 uM) and 6-thioguanine (10 uM), or the DNA incorporating agents trifluorothymidine (10 uM) and gemcitabine (100 nM) for 72 h. Subsequently, the cellular localization of the SG marker protein TIAR (green) and the P-body marker protein DCP1 (red) was analyzed. Nuclei were stained with Hoechst. Scale bars represent 20 um.
S1135	Pemetrexed Pemetrexed is a novel antifolate and antimetabolite for TS, DHFR and GARFT with K_i of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively.	Cancer Res, 2014, 74(21):5948-54 Mol Cancer Ther, 2012, 11(12):2633-43 Mol Cancer Res, 2013, 12(12):2675-84	Role of PARP and BER in the synergy between PTX and GMX in A549 cells. Cells were pretreated ±1 umol/L olaparib (2 hours) then sequentially ±150 nmol/L PTX (24 hours), then ± GMX 12 nmol/L (48 hours). PAR modification of proteins and γ-H2AX levels were measured in extracts treated as in A by Western blotting.
S1215	Carboplatin Carboplatin is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells.	Cancer Cell, 2013, 24(5):617-30 Nat Commun, 2016, 7:12351 Clin Cancer Res, 2014, 20(14):3849-61	(A) The BRCA1-mutated TNBC cell lines MDA-MB-436 and HCC1937 were treated with CBP (10 μM) plus GEM (100 nM) combined with or without olaparib (10 μM) for the indicated times, and then, the cell viability was determined with an MTT assay. The results show data from six independent experiments expressed as the mean ± SD. p < 0.05.
S5582^新	Cytarabine hydrochloride Cytarabine is a pyrimidine nucleoside analog that is used mainly in the treatment of leukemia. It is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA.
S5552^新	Amenamevir Amenamevir is a potent helicase-primase inhibitor and a novel class of antiviral agent.
S5293^新	Nimustine Hydrochloride Nimustine Hydrochloride is the hydrochloride salt of nimustine, a nitrosourea with antineoplastic activity that alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death.
S5297^新	Vidarabine monohydrate Vidarabine is a nucleoside antibiotic with antiviral acitivity that interferes with the synthesis of viral DNA. It is used to treat herpes simplex and varicella zoster viruses.
S5484^新	Rimantadine Hydrochloride Rimantadine is an RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza. It works by inhibiting a viral protein called M2, which normally mediates the transport of acid ions across the influenza virion shell.
S4782^新	5-methoxyflavone 5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity.
S1491	Fludarabine Fludarabine is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells.	Hepatology, 2018, 10.1002/hep.30317 EMBO Mol Med, 2015, 10.15252/emmm.201404580 Brain Behav Immun, 2017, 60:161-173
S2684	CX-5461 CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116, A375, and MIA PaCa-2 cells, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.	Cell, 2018, 174(2):338-349 Cell, 2018, 174(2):391-405 Nucleic Acids Res, 2018, 10.1093/nar/gky1107	Representative western blot evaluation and densitormetric analysis of p53 expression in control and CX-5461 (CX)-treated HCT116, HepG2, MCF7 and LoVo cells. Cells were exposed to 1 μM CX-5461 for 12 h.
S1209	Fluorouracil (5-Fluoracil, 5-FU) Fluorouracil (5-Fluoracil, 5-FU) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells.	Cancer Res, 2017, 77(18):5039-5053 J Invest Dermatol, 2018, 138(8):1716-1725 J Exp Clin Cancer Res, 2018, 37(1):151	DNA-PKcs suppression mediated ROS production and GSH content in HepG2 cells exposed to CDDP and 5-Fu. a DNA-PKcs inhibition promoted ROS production in HepG2 cells treated with indicated concentrations of CDDP and 5-Fu. DCFH-DA fluorescent analysis was performed to assess the ROS level. Data presented were mean ?SD of three independent experiments.
S1156	Capecitabine Capecitabine is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU.	Cancer Res, 2017, canres.1406.2017	Growth curve of human colon cancer xenografts in nude mice treated with orally administered vehicle or capecitabine at 360 mg/kg (n = 10–12 per cell line).
S1229	Fludarabine Phosphate Fludarabine Phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.	EMBO Mol Med, 2015, 10.15252/emmm.201404580 Basic Res Cardiol, 2014, 109(4):419 Cell Death Dis, 2014, 5:e1512	Imatinib mesylate (IM) in combination of F-AMP significantly inhibits Ki67 and c-KIT expression in GIST-T1 tumor xenografts. Tumors were collected on the day after the last treatment and were then subjected to H&E staining and immunohistochemical detection of Ki67, c-KIT, and cleaved caspase-3 expression. Representative images of H&E staining and immunohistochemical staining of Ki67, c-KIT, and cleaved caspase-3 in mice tumors. Arrows indicate the decrease in cellularity and the increase in stromal fibrosis. Magnification, x 400.
S1516	Cidofovir Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis.	Int J Oncol, 2016, 48(4):1519-30 Viruses, 2015, 7(5):2268-87	The copy numbers of the intracellular viral DNA were directly extracted from cells and were quantified by qPCR using primers specific for the KSHV ORF73 gene. Then each sample was normalized to the amount of the GAPDH gene (C), CDV (20 µM) was used as a positive control. CDV:Cidofovir.
S1648	Cytarabine Cytarabine is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells.	Leukemia, 2015, 10.1038/leu.2015.99 Cell Death Differ, 2014, 10.1038/cdd.2014.158 J Exp Clin Cancer Res, 2017, 36(1):22	Viability and CI vs Fa after 24-h exposure to cytarabine alone or in combination with ABT-199 in Riva, U2932 and VavP-Bcl2/c-MYC murine tumor cells. Viability shown at 500 nM (500 ng/ml for cytarabine; quadruplicates±s.e.m.).
S1714	Gemcitabine Gemcitabine, a nucleic acid synthesis inhibitor, is a very potent and specific deoxycytidine analogue, used as chemotherapy.	Nature, 2017, 552(7683):116-120 Cancer Discov, 2011, 1(4):352-65 Sci Transl Med, 2015, 7(284):284ra57	RNA incorporating drugs induce SG assembly. HeLa cells were treated with the RNA incorporating agents 5-azacytidine (50 uM) and 6-thioguanine (10 uM), or the DNA incorporating agents trifluorothymidine (10 uM) and gemcitabine (100 nM) for 72 h. Subsequently, the cellular localization of the SG marker protein TIAR (green) and the P-body marker protein DCP1 (red) was analyzed. Nuclei were stained with Hoechst. Scale bars represent 20 um.
S1213	Nelarabine Nelarabine is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.	J Hematol Oncol, 2016, 9(1):114	b) Western blot analysis documenting cleavage of caspase-8, caspase-9, caspase-3, and PARP by nelarabine. Cells were treated with nelarabine (5 μM for JURKAT, P12-ICHIKAWA, and DND-41 cells, 2 μM MOLT-4 cells) for the indicated times, collected, and then lysed. Fifty micrograms of each lysate were electrophoresed on SDS-PAGE gels followed by transfer onto a nitrocellulose membrane. c) Nelarabine induces a decrease in the phosphorylation status of critical components of the PI3K/AKT/mTOR signaling pathway, as well as p-ERK (Thr202) levels in T-ALL sensitive cell lines. Western blot analysis documenting the reduction of p-AKT (Ser473), p-S6RP, p-GSK3β (Ser9), and p-ERK (Thr202). Antibody to β-actin served as a loading control. Molecular weights are indicated on the right
S1373	Daptomycin Daptomycin is a novel antibiotic with rapid in vitro bactericidal activity against gram-positive organisms.	Biochim Biophys Acta, 2017, 1859(3):331-339 Biochemistry, 2014, 53(33):5384-92 PLoS One, 2016, 11(10):e0164227	Same experiment as in Figure 2 with fluorescent daptomycin shown as confocal images. A 7/3 DOPC/DOPG GUV (including 1% Rh-PE) was introduced at time zero into a solution containing 1 uM daptomycin with 0.5 uM BODIPY-daptomycin and 1 mM Ca2+. To show colocalization of lipid and peptide in aggregates, confocal images were taken: red for RH-PE and green for BODIPY-daptomycin. As the protrusion length decreased, aggregates appeared on the GUV surface containing both lipid and peptide. The scale bar is 10 um.
S1199	Cladribine Cladribine is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.	Cancer Chemoth Pharm, 2015, 10.1007/s00280-015-2713-z
S1192	Raltitrexed Raltitrexed is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.	Biochem Pharmacol, 2015, 93(3):305-17 PLoS One, 2015, 10(12):e0143947	Fig. 1. Raltitrexed dose-response curve. HEK293 parental and MRP5 transfected cells were plated in a 96-well plate at a density of 4000 cells/well in complete DMEM (10% FBS, 1% Pencillin/streptomycin) and allowed to incubate for 24h at 37°C, 5% CO2. Raltirexed was added and the cells allowed to incubate for 72h. Total DNA present in each well was then quantified using Cyquant® cell proliferation assay. Results show Total DNA as % of the DMSO-only control wells. Experiment was done in triplicate.
S1218	Clofarabine Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.	Clin Cancer Res, 2017, 10.1158/1078-0432.CCR-17-0263 Cancer Chemoth Pharm, 2015, 10.1007/s00280-015-2713-z	Immunoblot analysis of cell lysates of NCI-H929 cells treated with CLO (5 μM, 3-48 h) GAPDH served as the loading control for each membrane, and data are representative of at least two independent experiments
S1302	Ifosfamide Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.	Tumour Biol, 2016, 37(2):2341-51	Chemotherapeutic response. Ifosfamide was applied at different concentrations on Lipo-DUE1, Lipo246, and PLS-1 for 72 h. Subsequently, cell viability was determined by MTS assay at a wavelength of 490 nm. Values represent the mean±S.D. of triplicates
S2678	NSC 207895 NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.		Median overall survival of mice (n = 5 mice in vehicle and PYR-41; n = 4 mice in NSC group) inoculated with IOWA-1T xenografts were increased to 43 ± 0.5 and 39 ± 2 days with PYR-41 (PYR) and NSC-207895 (NSC), respectively, compared with a vehicle-treated control group 33 ± 1 days (*p < 0.05).
S1221	Dacarbazine Dacarbazine is a triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis; used in the treatment of various cancers.
S1896	Hydroxyurea Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.	Blood, 2017, 130(26):2848-2859 Oncogene, 2017, 36(45):6282-6292 BMC Cancer, 2018, 18(1):426
S1299	Floxuridine Floxuridine is an antineoplastic antimetabolite, used in the treatment of colon carcinoma and colorectal cancer that has metastasized to the liver.
S1305	Mercaptopurine (6-MP) Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.
S1384	Mizoribine Mizoribine is an imidazole nucleoside, selectively inhibits inosine monophosphate synthetase and guanosine monophosphate synthetase.
S1949	Menadione Menadione(Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.
S1289	Carmofur Carmofur is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer.
S4227	Fidaxomicin Fidaxomicin is a narrow spectrum macrocyclic antibiotic that inhibits RNA polymerase sigma subunit.
S1907	Metronidazole Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa.
S1760	Rifapentine Rifapentine is an antibiotic, which inhibits DNA-dependent RNA polymerase activity, used to treat tuberculosis.
S1778	Trifluridine Trifluridine is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.
S1790	Rifaximin Rifaximin is a RNA synthesis inhibitor by binding the β subunit of the bacterial DNA-dependent RNA polymerase, used to treat traveler's diarrhea caused by certain bacteria.
S1995	Procarbazine HCl Procarbazine HCl is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound, used for the treatment of Hodgkin's lymphoma.
S1784	Vidarabine Vidarabine is an antiviral drug by interfering with the synthesis of viral DNA, used to treat herpes simplex and varicella zoster viruses.
S1764	Rifampin Rifampin is a DNA-dependent RNA polymerase inhibitor, used to treat a number of bacterial infections.
S3001	Clevudine Clevudine is an antiviral drug for the treatment of hepatitis B.
S4252	Mechlorethamine HCl Mechlorethamine is the prototype of alkylating agents, it works by binding to DNA, crosslinking two strands and preventing cell duplication.
S1300	Tegafur (FT-207, NSC 148958) Tegafur (FT-207, NSC 148958) is a substance being used in the treatment of some types of cancer.
S1826	Nedaplatin Nedaplatin is a derivative of cisplatin and DNA damage agent for tumor colony forming units with IC50 of 94 μM.
S7470	Triapine Triapine is a potent ribonucleotide reductase inhibitor with broad spectrum antitumor activity by inhibiting DNA synthesis. Phase 2.	Nat Commun, 2016, 7:13398	(a) Quantification of p-RPA/ Rad51, 53BP1 and γH2AX in GBM01 cells treated with DMSO or triapine. (b) Quantification of p-RPA/Rad51, 53BP1 and γH2AX in GBM02 cells treated with DMSO or triapine.
S7757	6-Thio-dG 6-thio-dG is a nucleoside analog and telomerase substrate.
S4297	Mupirocin Mupirocin is an isoleucyl t-RNA synthetase inhibitor, used in the treatment of bacterial skin infections.
S8376	Rbin-1 Rbin-1(ribozinoindole-1) is a potent chemical inhibitor of eukaryotic ribosome assembly. It inhibits recombinant full-length Mdn1's ATPase activity in vitro.
S8095	Tubercidin Tubercidin, an adenosine analogue, is a nucleoside antibiotic. It is incorporated into DNA and inhibits polymerases, thereby inhibiting DNA replication and RNA and protein synthesis. This agent also exhibits antifungal and antiviral activities.
S4035	Vitamin D2 Vitamin D2 is a selective inhibitor of mammalian DNA polymerase A (pol A) with IC50 of 123 mM.
S7975	Favipiravir (T-705) Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections.	Cell Physiol Biochem, 2018, 49(1):381-394 Antiviral Res, 2017, 143:237-245
S8328	CeMMEC1 HCl CeMMEC1 is an N-methylisoquinolinone derivative that inhibits the second bromodomain of TAF1 (IC50=0.9 μM).
S4504	6-Mercaptopurine (6-MP) Monohydrate 6-Mercaptopurine Monohydrate is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.
S7742	SCR7 SCR7 is a specific DNA Ligase IV inhibitor, which blocks nonhomologous end-joining (NHEJ).	Mutat Res, 2017, 800-802:1-7	Knock-in efficiencies of mCherry knock-in at Actb locus by four strategies in mouse ES cells (A) were measured by FACS and compared with the group treated with NHEJ inhibitor (Scr7 or Nu7026), HR inhibitor (caffeine) or both. Results were presented as mean ± SD. P < 0.05, P < 0.01, **P < 0.001, unpaired Student’s t-test
S4737	Psoralen Psoralen is a naturally occurring furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division.
S8146	Mitomycin C Mitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers.	Oncogene, 2017, 10.1038/onc.2017.6 BMC Cancer, 2018, 18(1):426 Oncol Lett, 2017, 14(6):8035-8041
S1973	Cyclocytidine HCl Cyclocytidine is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia.
S7449	CRT0044876 CRT0044876 is a potent and selective APE1 inhibitor with IC50 of ~3 μM.
S7445	E3330 E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.
S2794	Sofosbuvir (PSI-7977, GS-7977) Sofosbuvir (PSI-7977, GS-7977) is a HCV NS5B polymerase inhibitor for the treatment of chronic hepatitis C virus (HCV) infection.	J Hepatol, 2018, 10.1016/j.jhep.2018.11.012 Hepatology, 2017, 66(3):758-771 Hepatology, 2018, 10.1002/hep.29837	Inhibition of hepatitis C virus by sofosbuvir. (A) Determination of 50% cytotoxic concentration (CC50). Huh-7.5 reporter cells (1.3×10⁴) were incubated with the indicated concentration of sofosbuvir (SOF) during 72 h at 37°C, and the numbers of viable cells were counted using MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide]. (B) Determination of the drug concentration required for 50% inhibition (IC50) of infectious HCV yield. Huh-7.5 reporter cells (1.0×10⁵) were infected with 3 103 TCID50 of HCV p0 in the presence of the indicated concentrations of SOF. Virus titers were determined in the cell culture supernatants at 72 h postinfection. Viral titers are given as the percentages of the titers obtained in the infection in the absence of SOF. (C) Progeny production in the course of three serial passages of HCV p0 in the presence of increasing concentrations of SOF, as indicated. Infection conditions are those explained in the description of panel B. Procedures are detailed in Materials and Methods.
S8434	B02 B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM).	J Virol, 2018, 92(15) Sci Rep, 2018, 8(1):14421
S8539	TAS-102 TAS-102 is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride.
S3669	Carmustine Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agent and used in the treatment of brain tumors and various other malignant neoplasms.
S7679	YK-4-279 YK-4-279 is a potent inhibitor of EWS-FLI1 binding to RNA helicase A (RHA).		YK-4-279-induced cell apoptosis of NB cells by Western blot assay. SH-SY5Y cells were treated with YK-4-279 (0, 0.1 μM, 0.3 μM, 1 μM, 3 μM) for 24 h. Whole cell lysates were subjected to SDS-PAGE and immunoblotted with antibodies against PARP and Caspase 3 to detect apoptosis. β-actin was detected as loading control. YK-4-279-induced apoptosis of NB cell line SH-SY5Y by FACS. Cells were treated with YK-4-279 (0, 1 μM, 3 μM) for 24 h, and then stained by PI and analyzed by FACS.
S7718	BMH-21 BMH-21 is a DNA intercalator, which binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription.	Cell, 2018, 174(2):338-349
S4239	Bergapten Bergapten is a psoralen that can be photoactivated and is capable of crossing-linking DNA, covalently modifying proteins and lipids, and consequently inhibiting cell replication.
S4537	Oxolinic acid Oxolinic acid is a quinolone antibiotic, inhibiting the enzyme DNA gyrase and DNA synthesis.It also acts as a dopamine reuptake inhibitor.
S7546	Pritelivir (BAY 57-1293) Pritelivir (BAY 57-1293) is a potent helicase primase inhibitor, exhibiting antiviral effect on herpes simplex virus (HSV) with IC50 of 20 nM for both HSV-1 and HSV-2.
S8329	CeMMEC13 CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 µM).
S4288	Chloroambucil Chlorambucil is a nitrogen mustard alkylating agent, used in the treatment of chronic lymphocytic leukemia.
S8246	RK-33 RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.
S8326	Saccharin 1-methylimidazole SMI is considered a general-purpose activator for DNA and RNA synthesis.
S1334	Flupirtine maleate Flupirtine maleate is the salt form of Flupirtine, which is a centrally acting non-opioid analgesia, is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.
S7444	Pyridostatin Trifluoroacetate Salt Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with K_d of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2.
S1214	Bleomycin Sulfate Bleomycin Sulfate is a glycopeptide antibiotic and an anticancer agent for squamous cell carcinomas (SCC) with IC50 of 4 nM in UT-SCC-19A cells.	Am J Respir Crit Care Med, 2015, 10.1164/rccm.201411-2128OC Nucleic Acids Res, 2015, 10.1093/nar/gkv208 Plant J, 2014, 78(5):822-33
S9382^新	Thymine Thymine is one of the four nucleobases in the nucleic acid of DNA.
S4888^新	Guanine Guanine is one of the four main nucleobases found in the nucleic acids DNA and RNA.
S5505^新	2’-deoxyuridine 2'-deoxyuridine is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms.
S5374^新	5'-Cytidylic acid 5'-Cytidylic acid is a nucleotide that is used as a monomer in RNA.
S1237	Temozolomide Temozolomide is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. A DNA damage inducer in L-1210 and L-1210/BCNU cells.	Nat Med, 2015, 10.1038/nm.3855 Clin Cancer Res, 2014, 20(6):1555-65 Clin Cancer Res, 2017, 23(2):523-535	C57BL/6 mice were implanted in the striatum with citrine-GL26-Cherry-HMGB1, which were stably transfected to express the YFP citrine and HMGB1 fused to red fluorescent protein cherry. Fourteen days later, they were treated with saline, Ad-TK+Ad-Flt3L, or Ad-TK+Ad-Flt3L+TMZ (temozolomide). Five days after treatment, the cellular location of cherry-HMGB1 in these cells was assessed by confocal microscopy. Arrows, tumor cells (green) with cytoplasmic HMGB1 (red).
S1212	Bendamustine HCl Bendamustine HCL is a DNA-damaging agent with IC50 of 50 μM in cell-free assay.	EMBO Mol Med, 2015, 10.15252/emmm.201404580 PLoS One, 2015, 10(8):e0135314 Clin Lymphoma Myeloma Leuk, 2013, 13 Suppl 2:S355-62	Cells were grown for 6-8 days in presence of increasing concentrations of (I) bendamustine. Relative toxicity of the drugs was determined by the WST-8 cell proliferation assay, Dashed lines with open circles or triangles indicate cell proliferation in absence of an anti-lymphoma drug. Other curves represent the cells grown in increasing concentrations (indicated by the associated number) of the tested drug. Maximal absorbance (highest number of viable cells) of cells grown without an anti-lymphoma agent in each experiment was set as 100%. Standard deviations were < 5% for all measurements.
S1840	Lomustine Lomustine inhibits cancer cells by damaging the DNA and stops cells from dividing.		Initial range finding concentration response analysis of the cytotoxic effects of (A) lomustine (IC50 = 12 μM) and (B) vincristine (IC50 = 1.5 nM) on D283 Med in a clonogenic assay of cell survival
S7918	Bromodeoxyuridine (BrdU) Bromodeoxyuridine (BrdU) is a nucleoside analog that competes with thymidine for incorporation into DNA, and used in the detection of proliferating cells.	Biomedicine & Pharmacotherapy, 2018, 10.1016/j.biopha.2018.11.029 PLoS One, 2016, 11(11):e0166386 Int J Ophthalmol, 2017, 10(4):507-514	Immunofluorescence microphotographs of proliferating ARPE-19 cell with BrdU (red) and DAPI (blue) staining after ARPE-19 cells were untreated or treated with AF (1.0 μM) in the absence or presence of EGF (100ng/ml) for 24 hours and then subjected to BrdU labeling for 4 hours, followed by immunostaining with anti-BrdU antibody and DAPI. Scale bar = 20μm.
S1981	Adenine Adenine is a purine derivative and a nucleobase with a variety of roles in biochemistry.
S1983	Adenine HCl Adenine HCl is a hydrochloride salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.
S1982	Adenine sulfate Adenine sulfate is a sulfate salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.
S2029	Uridine Uridine is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond.

研究分野別

製品類型

DNA/RNA合成

シグナル伝達経路

研究分野