DNA/RNA合成

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1166 Cisplatin <1 mg/mL 60 mg/mL '''''<1 mg/mL
S1149 Gemcitabine HCl 19 mg/mL <1 mg/mL '''<1 mg/mL
S1135 Pemetrexed 94 mg/mL <1 mg/mL '<1 mg/mL
S1215 Carboplatin 14 mg/mL <1 mg/mL '''''<1 mg/mL
S9649 Acelarin (NUC-1031) <1 mg/mL 100 mg/mL '''20 mg/mL
S8977 BCH001 <1 mg/mL 84 mg/mL '''5 mg/mL
S8850 JH-RE-06 <1 mg/mL 12 mg/mL '<1 mg/mL
S6848 3'-Fluoro-3'-deoxythymidine (Alovudine) 20 mg/mL 49 mg/mL '40 mg/mL
S0469 ML216 ˂1 mg/mL 38 mg/mL ˂1 mg/mL
S0280 Madrasin <1 mg/mL 1 mg/mL '''3 mg/mL
S0102 L 189 ˂1 mg/mL 49 mg/mL '''˂1 mg/mL
S0054 D-I03 <1 mg/mL 86 mg/mL ''''10 mg/mL
S2600 Fexinidazole <1 mg/mL 56 mg/mL <1 mg/mL
S8932 Remdesivir (GS-5734) <1 mg/mL 100 mg/mL '16 mg/mL
S9521 Pentostatin 54 mg/mL 54 mg/mL <1 mg/mL
S1491 Fludarabine <1 mg/mL 57 mg/mL ''<1 mg/mL
S1224 Oxaliplatin 3 mg/mL -1 mg/mL ''''0.01 mg/mL
S2684 CX-5461 <1 mg/mL 0.02 mg/mL <1 mg/mL
S1209 Fluorouracil (5-Fluorouracil, 5-FU) <1 mg/mL 26 mg/mL ''<1 mg/mL
S1156 Capecitabine 6 mg/mL 72 mg/mL ''''72 mg/mL
S1229 Fludarabine Phosphate 2 mg/mL 73 mg/mL '<1 mg/mL
S1117 Triciribine <1 mg/mL 64 mg/mL ''<1 mg/mL
S1516 Cidofovir 12 mg/mL 2 mg/mL ''<1 mg/mL
S1648 Cytarabine 48 mg/mL 1 mg/mL '''''<1 mg/mL
S1714 Gemcitabine 52 mg/mL 52 mg/mL ''<1 mg/mL
S1213 Nelarabine 3 mg/mL 60 mg/mL '<1 mg/mL
S1373 Daptomycin 100 mg/mL 100 mg/mL '<1 mg/mL
S3035 Daunorubicin HCl 100 mg/mL 100 mg/mL ''<1 mg/mL
S1199 Cladribine <1 mg/mL 57 mg/mL ''<1 mg/mL
S1192 Raltitrexed <1 mg/mL 91 mg/mL '<1 mg/mL
S1218 Clofarabine <1 mg/mL 60 mg/mL ''<1 mg/mL
S1302 Ifosfamide 52 mg/mL 52 mg/mL ''52 mg/mL
S2678 NSC 207895 <1 mg/mL 0.4 mg/mL '<1 mg/mL
S1221 Dacarbazine 2 mg/mL 12 mg/mL '1 mg/mL
S1896 Hydroxyurea 15 mg/mL 15 mg/mL ''<1 mg/mL
S1807 Aciclovir <1 mg/mL 45 mg/mL ''''<1 mg/mL
S1299 Floxuridine 49 mg/mL 49 mg/mL ''10 mg/mL
S1305 Mercaptopurine (6-MP) <1 mg/mL 30 mg/mL <1 mg/mL
S1384 Mizoribine 51 mg/mL 1 mg/mL ''<1 mg/mL
S1949 Menadione <1 mg/mL 34 mg/mL '34 mg/mL
S2239 Tubacin <1 mg/mL 100 mg/mL ''<1 mg/mL
S1289 Carmofur <1 mg/mL 52 mg/mL ''10 mg/mL
S4227 Fidaxomicin <1 mg/mL 100 mg/mL <1 mg/mL
S1907 Metronidazole <1 mg/mL 34 mg/mL <1 mg/mL
S1760 Rifapentine <1 mg/mL 100 mg/mL '17 mg/mL
S1778 Trifluridine 59 mg/mL 59 mg/mL '59 mg/mL
S1790 Rifaximin <1 mg/mL 47 mg/mL 3 mg/mL
S1995 Procarbazine HCl 52 mg/mL <1 mg/mL '52 mg/mL
S1784 Vidarabine 3 mg/mL 53 mg/mL <1 mg/mL
S1764 Rifampin <1 mg/mL 100 mg/mL '<1 mg/mL
S3001 Clevudine 52 mg/mL 52 mg/mL 4 mg/mL
S1300 Tegafur (FT-207) 8 mg/mL 40 mg/mL 7 mg/mL
S1826 Nedaplatin 18 mg/mL <1 mg/mL <1 mg/mL
S7470 Triapine <1 mg/mL 20 mg/mL '''<1 mg/mL
S7757 6-Thio-dG <1 mg/mL 56 mg/mL <1 mg/mL
S4297 Mupirocin 46 mg/mL 100 mg/mL 100 mg/mL
S8376 Rbin-1 <1 mg/mL 23 mg/mL 1 mg/mL
S8095 Tubercidin <1 mg/mL 53 mg/mL '<1 mg/mL
S4035 Vitamin D2 <1 mg/mL 20 mg/mL ''80 mg/mL
S7975 Favipiravir (T-705) 5 mg/mL 31 mg/mL '22 mg/mL
S8328 CeMMEC1 HCl <1 mg/mL 23 mg/mL 1 mg/mL
S5484 Rimantadine Hydrochloride -1 mg/mL 43 mg/mL -1 mg/mL
S4504 6-Mercaptopurine (6-MP) Monohydrate <1 mg/mL 34 mg/mL <1 mg/mL
S7742 SCR7 <1 mg/mL 66 mg/mL 3 mg/mL
S4737 Psoralen <1 mg/mL 37 mg/mL <1 mg/mL
S8146 Mitomycin C <1 mg/mL 66 mg/mL '<1 mg/mL
S1973 Cyclocytidine HCl 44 mg/mL 10 mg/mL <1 mg/mL
S3641 Osalmid <1 mg/mL 45 mg/mL '45 mg/mL
S7449 CRT0044876 <1 mg/mL 41 mg/mL '1 mg/mL
S7445 E3330 <1 mg/mL 75 mg/mL '75 mg/mL
S5293 Nimustine Hydrochloride -1 mg/mL 61 mg/mL '-1 mg/mL
S5297 Vidarabine monohydrate -1 mg/mL 57 mg/mL -1 mg/mL
S2794 Sofosbuvir (GS-7977) 11 mg/mL 100 mg/mL '''100 mg/mL
S8434 B02 <1 mg/mL 67 mg/mL 20 mg/mL
S8539 TAS-102 15 mg/mL 100 mg/mL 100 mg/mL
S7637 DTP3 100 mg/mL 100 mg/mL ''100 mg/mL
S8144 Halofuginone <1 mg/mL 20 mg/mL '<1 mg/mL
S3669 Carmustine ' mg/mL
S7679 YK-4-279 <1 mg/mL 73 mg/mL 51 mg/mL
S4236 Proflavine Hemisulfate 22 mg/mL <1 mg/mL <1 mg/mL
S7718 BMH-21 <1 mg/mL 5 mg/mL 2 mg/mL
S4239 Bergapten <1 mg/mL 5 mg/mL <1 mg/mL
S4782 5-methoxyflavone -1 mg/mL 50 mg/mL -1 mg/mL
S4537 Oxolinic acid <1 mg/mL 0.5 mg/mL <1 mg/mL
S7546 Pritelivir (BAY 57-1293) <1 mg/mL 80 mg/mL <1 mg/mL
S8329 CeMMEC13 <1 mg/mL 67 mg/mL 6 mg/mL
S5582 Cytarabine hydrochloride -1 mg/mL 55 mg/mL -1 mg/mL
S7419 Blasticidin S HCl 91 mg/mL <1 mg/mL '<1 mg/mL
S4288 Chloroambucil <1 mg/mL 60 mg/mL 60 mg/mL
S8246 RK-33 <1 mg/mL 85 mg/mL '<1 mg/mL
S6893 PIN1 inhibitor API-1 <1 mg/mL 73 mg/mL ''2 mg/mL
S2427 Triglycidyl Isocyanurate (Teroxirone) <1 mg/mL 59 mg/mL <1 mg/mL
S8326 Saccharin 1-methylimidazole (SMI) 53 mg/mL 53 mg/mL '53 mg/mL
S1334 Flupirtine maleate <1 mg/mL 84 mg/mL 2 mg/mL
S7444 Pyridostatin Trifluoroacetate Salt 100 mg/mL 100 mg/mL ''30 mg/mL
S1214 Bleomycin Sulfate 100 mg/mL 100 mg/mL '''<1 mg/mL
S6854 Triazavirin 20 mg/mL 57 mg/mL '''<1 mg/mL
S1237 Temozolomide <1 mg/mL 38 mg/mL ''<1 mg/mL
S1212 Bendamustine HCl 2 mg/mL 78 mg/mL '17 mg/mL
S1840 Lomustine <1 mg/mL 46 mg/mL ''<1 mg/mL
S7918 Bromodeoxyuridine (BrdU) <1 mg/mL 61 mg/mL 2 mg/mL
S4888 Guanine <1 mg/mL 0.1 mg/mL <1 mg/mL
S5505 2’-deoxyuridine -1 mg/mL 45 mg/mL -1 mg/mL
S6359 Purine -1 mg/mL 24 mg/mL -1 mg/mL
S4194 Azaguanine-8 <1 mg/mL 6 mg/mL <1 mg/mL
S4803 Thymidine -1 mg/mL 48 mg/mL '-1 mg/mL
S1981 Adenine <1 mg/mL <1 mg/mL '<1 mg/mL
S1983 Adenine HCl 4 mg/mL 8 mg/mL <1 mg/mL
S1982 Adenine sulfate 2 mg/mL <1 mg/mL <1 mg/mL
S6077 Cytidine 5′-triphosphate (disodium salt) -1 mg/mL 18 mg/mL -1 mg/mL
S5374 5'-Cytidylic acid 64 mg/mL <1 mg/mL '-1 mg/mL
S5384 UTP, Trisodium Salt 100 mg/mL <1 mg/mL -1 mg/mL
S3190 N6-methyladenosine (m6A) 14 mg/mL 47 mg/mL 2 mg/mL
S2029 Uridine 49 mg/mL 49 mg/mL '<1 mg/mL
S9382 Thymine -1 mg/mL 25 mg/mL -1 mg/mL

DNA/RNA Synthesis製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1166

Cisplatin

Cisplatin (cisplatinum, cis-diamminedichloroplatinum II, CDDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. Cisplatin activates ferroptosis and induces autophagy. Solutions are best fresh-prepared.

S1149

Gemcitabine HCl

Gemcitabine HCl (LY188011) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.

S1135

Pemetrexed

Pemetrexed (LY-231514) is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.

S1215

Carboplatin

Carboplatin (JM-8, CBDCA, NSC 241240) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. Solutions are best fresh-prepared.

S9649

Acelarin (NUC-1031)

Acelarin (NUC-1031), a prodrug based on an aryloxy phosphoramidate derivative of gemcitabine, is a DNA synthesis inhibitor with EC50 of 0.2 nM.

S8977

BCH001

BCH001 is a specific PAPD5 inhibitor that restores telomerase activity and telomere length in dyskeratosis congenita (DC) patient induced pluripotent stem cells. PAPD5 is a noncanonical poly(A) polymerase with an unusual RNA-binding motif.

S8850

JH-RE-06

JH-RE-06 is a potent REV1-REV7 interface inhibitor with an IC50 of 0.78 μM and Kd value of 0.42 μM, disrupting REV1-POL ζ-mediated mutagenic translesion synthesis (TLS).

S6848

3'-Fluoro-3'-deoxythymidine (Alovudine)

3'-Fluoro-3'-deoxythymidine (Alovudine) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer.

S0469

ML216

ML216 is a potent and selective inhibitor of the DNA unwinding activity of BLM(Bloom’s syndrome protein) with antitumor activity. ML216 inhibits helicases with IC50 of 0.97 μM and 2.98 μM for BLM636-1298 and BLMfull-length, respectively.

S0280

Madrasin

Madrasin (DDD00107587) is a potent and cell-penetrant pre-mRNA splicing inhibitor. Madrasin interferes with the early stages of spliceosome assembly and stalls spliceosome assembly at the A complex.

S0102

L 189

L 189 is a novel human DNA ligase inhibitor with IC50 of 5 μM, 9 μM and 5 μM for hLigI, hLigIII and hLigIV, respectively. L 189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L 189 specifically sensitizes cancer cells to DNA damage.

S0054

D-I03

D-I03 is a selective inhibitor of RAD52 with Kd of 25.8 µM. D-I03 inhibits ssDNA annealing by RAD52 and D-loop formation with IC50 of 5 µM and 8 µM, respectively.

S2600

Fexinidazole

Fexinidazole is a 5-nitroimidazole derivative. Fexinidazole is a DNA synthesis inhibitor and the only, all-oral agent for Human African Trypanosomiasis(HAT or sleeping sickness).

S8932

Remdesivir (GS-5734)

Remdesivir,a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV.

S9521

Pentostatin

Pentostatin is a potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.

S1491

Fludarabine

Fludarabine (FaraA, Fludarabinum) is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis.

S1224

Oxaliplatin

Oxaliplatin (L-OHP) is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells. DMF is recommended for dissolution. Solutions are best fresh-prepared.

S2684

CX-5461

CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116, A375, and MIA PaCa-2 cells, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.

S1209

Fluorouracil (5-Fluorouracil, 5-FU)

Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.

S1156

Capecitabine

Capecitabine (RO 09-1978) is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU. Capecitabine treatment of HCT-15 cells causes condensation of DNA and induces apoptosis.

S1229

Fludarabine Phosphate

Fludarabine Phosphate (F-ara-A, NSC 312887) is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.

S1117

Triciribine

Triciribine (NSC 154020, VD-0002, vqd-002, API-2) is a DNA synthesis inhibitor, also inhibits Akt in PC3 cell line and HIV-1 in CEM-SS, H9, H9IIIB, U1 cells with IC50 of 130 nM and 20 nM, respectively; does not inhibit PI3K/PDK1; 5000-fold less active in cells lacking adenosine kinase. Phase 1/2.

S1516

Cidofovir

Cidofovir (HPMPC) suppresses virus replication by selective inhibition of viral DNA synthesis.

S1648

Cytarabine

Cytarabine (Cytarabin, Ara-C, Arabinofuranosyl Cytidine) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. Cytarabine induces autophagy and apoptosis.

S1714

Gemcitabine

Gemcitabine (LY-188011, NSC 613327), a nucleic acid synthesis inhibitor, is a very potent and specific deoxycytidine analogue, used as chemotherapy. Gemcitabine induces a potent p53-dependent apoptosis.

S1213

Nelarabine

Nelarabine (506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.

S1373

Daptomycin

Daptomycin (LY146032) is a novel antibiotic with rapid in vitro bactericidal activity against gram-positive organisms.

S3035

Daunorubicin HCl

Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay. Daunorubicin is a topoisomerase II inhibitor that induces apoptosis.

S1199

Cladribine

Cladribine (2-CdA, 2-chlorodeoxyadenosine) is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.

S1192

Raltitrexed

Raltitrexed (ZD-1694) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.

S1218

Clofarabine

Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (RNR) (IC50 = 65 nM) and DNA polymerase. Clofarabine induces autophagy and apoptosis.

S1302

Ifosfamide

Ifosfamide (NSC109724, Isophosphamide) is a nitrogen mustard alkylating agent used in the treatment of cancer.

S2678

NSC 207895

NSC 207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.

S1221

Dacarbazine

Dacarbazine (DTIC-Dome) is a triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis; used in the treatment of various cancers.

S1896

Hydroxyurea

Hydroxyurea (nci-c04831, nsc32065) is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. Hydroxyurea activates apoptosis and autophagy. Hydroxyurea is used to treat HIV infection.

S1807

Aciclovir

Acyclovir (Acyclovir, Acycloguanosine, Zovirax) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells.

S1299

Floxuridine

Floxuridine (Deoxyfluorouridine, FUDR, NSC 27640) is an antineoplastic antimetabolite, used in the treatment of colon carcinoma and colorectal cancer that has metastasized to the liver.

S1305

Mercaptopurine (6-MP)

Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.

S1384

Mizoribine

Mizoribine (Bredinin, NSC 289637) is an imidazole nucleoside and an immunosuppressant that inhibits HCV RNA replication with IC50 of ~ 100 μM for anti-HCV activity. Mizoribine is a selective inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH) and guanosine monophosphate synthetase. Mizoribine also inhibits SARS-CoV.

S1949

Menadione

Menadione(Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.

S2239

Tubacin

Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1. Tubacin reduces the replication of the Japanese Encephalitis Virus via the decrease of viral RNA synthesis.

S1289

Carmofur

Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer.

S4227

Fidaxomicin

Fidaxomicin is a narrow spectrum macrocyclic antibiotic that inhibits RNA polymerase sigma subunit.

S1907

Metronidazole

Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa.

S1760

Rifapentine

Rifapentine (MDL473) is an antibiotic, which inhibits DNA-dependent RNA polymerase activity, used to treat tuberculosis.

S1778

Trifluridine

Trifluridine (NSC 529182, NSC 75520) is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.

S1790

Rifaximin

Rifaximin is a RNA synthesis inhibitor by binding the β subunit of the bacterial DNA-dependent RNA polymerase, used to treat traveler's diarrhea caused by certain bacteria.

S1995

Procarbazine HCl

Procarbazine HCl (NSC-77213) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound, used for the treatment of Hodgkin's lymphoma.

S1784

Vidarabine

Vidarabine is an antiviral drug by interfering with the synthesis of viral DNA, used to treat herpes simplex and varicella zoster viruses.

S1764

Rifampin

Rifampin (Rimactane, Rifampicin) is a DNA-dependent RNA polymerase inhibitor, used to treat a number of bacterial infections.

S3001

Clevudine

Clevudine is an antiviral drug for the treatment of hepatitis B.

S1300

Tegafur (FT-207)

Tegafur (FT-207, NSC 148958) is a substance being used in the treatment of some types of cancer.

S1826

Nedaplatin

Nedaplatin is a derivative of cisplatin and DNA damage agent for tumor colony forming units with IC50 of 94 μM.

S7470

Triapine

Triapine (3-AP) is a potent ribonucleotide reductase (RNR) inhibitor with broad spectrum antitumor activity by inhibiting DNA synthesis. Phase 2.

S7757

6-Thio-dG

6-thio-dG is a nucleoside analog and telomerase substrate.

S4297

Mupirocin

Mupirocin is an isoleucyl t-RNA synthetase inhibitor, used in the treatment of bacterial skin infections.

S8376

Rbin-1

Rbin-1(ribozinoindole-1) is a potent chemical inhibitor of eukaryotic ribosome assembly. It inhibits recombinant full-length Mdn1's ATPase activity in vitro.

S5552

Amenamevir

Amenamevir is a potent helicase-primase inhibitor and a novel class of antiviral agent.

S8095

Tubercidin

Tubercidin (7-deaza-adenosine), an adenosine analogue, is a nucleoside antibiotic. It is incorporated into DNA and inhibits polymerases, thereby inhibiting DNA replication and RNA and protein synthesis. This agent also exhibits antifungal and antiviral activities.

S4035

Vitamin D2

Vitamin D2 is a selective inhibitor of mammalian DNA polymerase A (pol A) with IC50 of 123 μM.

S7975

Favipiravir (T-705)

Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections.

S8328

CeMMEC1 HCl

CeMMEC1 is an N-methylisoquinolinone derivative that inhibits the second bromodomain of TAF1 (IC50=0.9 μM).

S5484

Rimantadine Hydrochloride

Rimantadine is an RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza. It works by inhibiting a viral protein called M2, which normally mediates the transport of acid ions across the influenza virion shell.

S4504

6-Mercaptopurine (6-MP) Monohydrate

6-Mercaptopurine Monohydrate is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.

S7742

SCR7

SCR7 is a specific DNA Ligase IV inhibitor, which blocks nonhomologous end-joining (NHEJ).

S4737

Psoralen

Psoralen is a naturally occurring furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division.

S8146

Mitomycin C

Mitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.

S1973

Cyclocytidine HCl

Cyclocytidine (NSC 145668) is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia.

S3641

Osalmid

Osalmid suppresses ribonucleotide reductase (RR) activity in a concentration-dependent manner, with a 50% RR activity-inhibitory concentration (IC50) of 8.23 μM.

S7449

CRT0044876

CRT0044876 (NSC 69877, 7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM.

S7445

E3330

E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.

S5293

Nimustine Hydrochloride

Nimustine Hydrochloride (Nidran) is the hydrochloride salt of nimustine, a nitrosourea with antineoplastic activity that alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death.

S5297

Vidarabine monohydrate

Vidarabine is a nucleoside antibiotic with antiviral acitivity that interferes with the synthesis of viral DNA. It is used to treat herpes simplex and varicella zoster viruses.

S2794

Sofosbuvir (GS-7977)

Sofosbuvir (PSI-7977, GS-7977) is a HCV NS5B polymerase inhibitor for the treatment of chronic hepatitis C virus (HCV) infection.

S6115

Pyridoxal 5′-phosphate hydrate

Pyridoxal 5′-phosphate, a vitamin B6 phosphate, is a coenzyme in a variety of enzymatic reactions.

S8434

B02

B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM).

S8539

TAS-102

TAS-102 is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride.

S7637

DTP3

DTP3 is a selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor and is able to restore MKK7/JNK activation. DTP3 inhibits cancer-selective NF-κB survival pathway.

S8144

Halofuginone

Halofuginone is the competitively inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in mammal.

S3669

Carmustine

Carmustine (bis-chloroethylnitrosourea, BCNU, BiCNU) is a cell-cycle phase nonspecific alkylating antineoplastic agent and used in the treatment of brain tumors and various other malignant neoplasms.

S7679

YK-4-279

YK-4-279 is a potent inhibitor of EWS-FLI1 binding to RNA helicase A (RHA).

S4236

Proflavine Hemisulfate

Proflavine Hemisulfate is a topical antiseptic by interchelating DNA, thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands.

S7718

BMH-21

BMH-21 is a DNA intercalator, which binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription.

S4239

Bergapten

Bergapten is a psoralen that can be photoactivated and is capable of crossing-linking DNA, covalently modifying proteins and lipids, and consequently inhibiting cell replication.

S4782

5-methoxyflavone

5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity.

S4537

Oxolinic acid

Oxolinic acid is a quinolone antibiotic, inhibiting the enzyme DNA gyrase and DNA synthesis.It also acts as a dopamine reuptake inhibitor.

S7546

Pritelivir (BAY 57-1293)

Pritelivir (BAY 57-1293) is a potent helicase primase inhibitor, exhibiting antiviral effect on herpes simplex virus (HSV) with IC50 of 20 nM for both HSV-1 and HSV-2.

S8329

CeMMEC13

CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 µM).

S5582

Cytarabine hydrochloride

Cytarabine is a pyrimidine nucleoside analog that is used mainly in the treatment of leukemia. It is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA.

S7419

Blasticidin S HCl

Blasticidin S HCl is a nucleoside antibiotic isolated from Stretomyces girseochromogenes, and acts as a DNA and protein synthesis inhibitor, used to select transfected cells carrying bsr or BSD resistance genes.

S4288

Chloroambucil

Chlorambucil is a nitrogen mustard alkylating agent, used in the treatment of chronic lymphocytic leukemia.

S8246

RK-33

RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.

S6893

PIN1 inhibitor API-1

PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor with IC50 of 72.3 nM. PIN1 inhibitor API-1 targets Pin1 peptidyl-prolyl isomerase domain and inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 up-regulates miRNA biogenesis by retaining active XPO5 conformation and suppresses HCC development.

S2427

Triglycidyl Isocyanurate (Teroxirone)

Triglycidyl Isocyanurate, also known as Teroxirone, is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry.

S8326

Saccharin 1-methylimidazole (SMI)

Saccharin 1-methylimidazole (SMI) is considered a general-purpose activator for DNA and RNA synthesis.

S1334

Flupirtine maleate

Flupirtine maleate is the salt form of Flupirtine, which is a centrally acting non-opioid analgesia, is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.

S7444

Pyridostatin Trifluoroacetate Salt

Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes.

S1214

Bleomycin Sulfate

Bleomycin Sulfate (NSC125066) is a glycopeptide antibiotic and an anticancer agent for squamous cell carcinomas (SCC) with IC50 of 4 nM in UT-SCC-19A cells.

S6854

Triazavirin

Triazavirin is a novel antiviral drug, a nucleoside analogue of nucleic acid that inhibits the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin is active against influenza and a number of other viruses. Triazavirin is an effective protective agent on the transmission stage of influenza.

S1237

Temozolomide

Temozolomide (CCRG81045, NSC 362856, TMZ) is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. A DNA damage inducer in L-1210 and L-1210/BCNU cells. Temozolomide induces apoptosis and exhibits antitumor activity.

S1212

Bendamustine HCl

Bendamustine (SDX-105, Cytostasane) HCl is a DNA-damaging agent with IC50 of 50 μM in cell-free assay.

S1840

Lomustine

Lomustine (nsc79037, Gleostine, CeeNU, CCNU) inhibits cancer cells by damaging the DNA and stops cells from dividing.

S7918

Bromodeoxyuridine (BrdU)

Bromodeoxyuridine (BrdU) is a nucleoside analog that competes with thymidine for incorporation into DNA, and used in the detection of proliferating cells.

S4888

Guanine

Guanine is one of the four main nucleobases found in the nucleic acids DNA and RNA.

S5505

2’-deoxyuridine

2'-deoxyuridine is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms.

S6359

Purine

Purine is a heterocyclic aromatic organic compound which plays crucial roles in DNA and RNA. It is also significant components in a number of other important biomolecules, such as ATP, GTP, cyclic AMP, NADH, and coenzyme A.

S4194

Azaguanine-8

Azaguanine-8 is a purine analogs showing antineoplastic activity by competing with guanine in the metabolism.

S4803

Thymidine

Thymidine (Deoxythymidine, 2'-Deoxythymidine, 5-Methyldeoxyuridine) is a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose. As a constituent of DNA, thymidine pairs with adenine in the DNA double helix.

S1981

Adenine

Adenine is a purine derivative and a nucleobase with a variety of roles in biochemistry.

S1983

Adenine HCl

Adenine HCl is a hydrochloride salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.

S1982

Adenine sulfate

Adenine sulfate is a sulfate salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.

S6077

Cytidine 5′-triphosphate (disodium salt)

Cytidine 5'-triphosphate is a pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions. It is used in the synthesis of RNA by RNA polymerases.

S5374

5'-Cytidylic acid

5'-Cytidylic acid (Cytidine monophosphate, Cytidine 5'-phosphate) is a nucleotide that is used as a monomer in RNA.

S5384

UTP, Trisodium Salt

Uridine-5'-triphosphate (UTP) is a pyrimidine nucleoside triphosphate and a substrate for the synthesis of RNA during transcription.

S3190

N6-methyladenosine (m6A)

N6-methyladenosine (m6A, NSC-29409) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs.

S2029

Uridine

Uridine (NSC 20256) is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond.

S9382

Thymine

Thymine is one of the four nucleobases in the nucleic acid of DNA.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1166

Cisplatin

Cisplatin (cisplatinum, cis-diamminedichloroplatinum II, CDDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. Cisplatin activates ferroptosis and induces autophagy. Solutions are best fresh-prepared.

S1149

Gemcitabine HCl

Gemcitabine HCl (LY188011) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.

S1135

Pemetrexed

Pemetrexed (LY-231514) is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.

S1215

Carboplatin

Carboplatin (JM-8, CBDCA, NSC 241240) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. Solutions are best fresh-prepared.

S9649

Acelarin (NUC-1031)

Acelarin (NUC-1031), a prodrug based on an aryloxy phosphoramidate derivative of gemcitabine, is a DNA synthesis inhibitor with EC50 of 0.2 nM.

S8977

BCH001

BCH001 is a specific PAPD5 inhibitor that restores telomerase activity and telomere length in dyskeratosis congenita (DC) patient induced pluripotent stem cells. PAPD5 is a noncanonical poly(A) polymerase with an unusual RNA-binding motif.

S8850

JH-RE-06

JH-RE-06 is a potent REV1-REV7 interface inhibitor with an IC50 of 0.78 μM and Kd value of 0.42 μM, disrupting REV1-POL ζ-mediated mutagenic translesion synthesis (TLS).

S6848

3'-Fluoro-3'-deoxythymidine (Alovudine)

3'-Fluoro-3'-deoxythymidine (Alovudine) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer.

S0469

ML216

ML216 is a potent and selective inhibitor of the DNA unwinding activity of BLM(Bloom’s syndrome protein) with antitumor activity. ML216 inhibits helicases with IC50 of 0.97 μM and 2.98 μM for BLM636-1298 and BLMfull-length, respectively.

S0280

Madrasin

Madrasin (DDD00107587) is a potent and cell-penetrant pre-mRNA splicing inhibitor. Madrasin interferes with the early stages of spliceosome assembly and stalls spliceosome assembly at the A complex.

S0102

L 189

L 189 is a novel human DNA ligase inhibitor with IC50 of 5 μM, 9 μM and 5 μM for hLigI, hLigIII and hLigIV, respectively. L 189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L 189 specifically sensitizes cancer cells to DNA damage.

S0054

D-I03

D-I03 is a selective inhibitor of RAD52 with Kd of 25.8 µM. D-I03 inhibits ssDNA annealing by RAD52 and D-loop formation with IC50 of 5 µM and 8 µM, respectively.

S2600

Fexinidazole

Fexinidazole is a 5-nitroimidazole derivative. Fexinidazole is a DNA synthesis inhibitor and the only, all-oral agent for Human African Trypanosomiasis(HAT or sleeping sickness).

S8932

Remdesivir (GS-5734)

Remdesivir,a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV.

S9521

Pentostatin

Pentostatin is a potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.

S1491

Fludarabine

Fludarabine (FaraA, Fludarabinum) is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis.

S1224

Oxaliplatin

Oxaliplatin (L-OHP) is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells. DMF is recommended for dissolution. Solutions are best fresh-prepared.

S2684

CX-5461

CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116, A375, and MIA PaCa-2 cells, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.

S1209

Fluorouracil (5-Fluorouracil, 5-FU)

Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.

S1156

Capecitabine

Capecitabine (RO 09-1978) is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU. Capecitabine treatment of HCT-15 cells causes condensation of DNA and induces apoptosis.

S1229

Fludarabine Phosphate

Fludarabine Phosphate (F-ara-A, NSC 312887) is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.

S1117

Triciribine

Triciribine (NSC 154020, VD-0002, vqd-002, API-2) is a DNA synthesis inhibitor, also inhibits Akt in PC3 cell line and HIV-1 in CEM-SS, H9, H9IIIB, U1 cells with IC50 of 130 nM and 20 nM, respectively; does not inhibit PI3K/PDK1; 5000-fold less active in cells lacking adenosine kinase. Phase 1/2.

S1516

Cidofovir

Cidofovir (HPMPC) suppresses virus replication by selective inhibition of viral DNA synthesis.

S1648

Cytarabine

Cytarabine (Cytarabin, Ara-C, Arabinofuranosyl Cytidine) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. Cytarabine induces autophagy and apoptosis.

S1714

Gemcitabine

Gemcitabine (LY-188011, NSC 613327), a nucleic acid synthesis inhibitor, is a very potent and specific deoxycytidine analogue, used as chemotherapy. Gemcitabine induces a potent p53-dependent apoptosis.

S1213

Nelarabine

Nelarabine (506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.

S1373

Daptomycin

Daptomycin (LY146032) is a novel antibiotic with rapid in vitro bactericidal activity against gram-positive organisms.

S3035

Daunorubicin HCl

Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay. Daunorubicin is a topoisomerase II inhibitor that induces apoptosis.

S1199

Cladribine

Cladribine (2-CdA, 2-chlorodeoxyadenosine) is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.

S1192

Raltitrexed

Raltitrexed (ZD-1694) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.

S1218

Clofarabine

Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (RNR) (IC50 = 65 nM) and DNA polymerase. Clofarabine induces autophagy and apoptosis.

S1302

Ifosfamide

Ifosfamide (NSC109724, Isophosphamide) is a nitrogen mustard alkylating agent used in the treatment of cancer.

S2678

NSC 207895

NSC 207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.

S1221

Dacarbazine

Dacarbazine (DTIC-Dome) is a triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis; used in the treatment of various cancers.

S1896

Hydroxyurea

Hydroxyurea (nci-c04831, nsc32065) is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. Hydroxyurea activates apoptosis and autophagy. Hydroxyurea is used to treat HIV infection.

S1807

Aciclovir

Acyclovir (Acyclovir, Acycloguanosine, Zovirax) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells.

S1299

Floxuridine

Floxuridine (Deoxyfluorouridine, FUDR, NSC 27640) is an antineoplastic antimetabolite, used in the treatment of colon carcinoma and colorectal cancer that has metastasized to the liver.

S1305

Mercaptopurine (6-MP)

Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.

S1384

Mizoribine

Mizoribine (Bredinin, NSC 289637) is an imidazole nucleoside and an immunosuppressant that inhibits HCV RNA replication with IC50 of ~ 100 μM for anti-HCV activity. Mizoribine is a selective inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH) and guanosine monophosphate synthetase. Mizoribine also inhibits SARS-CoV.

S1949

Menadione

Menadione(Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.

S2239

Tubacin

Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1. Tubacin reduces the replication of the Japanese Encephalitis Virus via the decrease of viral RNA synthesis.

S1289

Carmofur

Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer.

S4227

Fidaxomicin

Fidaxomicin is a narrow spectrum macrocyclic antibiotic that inhibits RNA polymerase sigma subunit.

S1907

Metronidazole

Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa.

S1760

Rifapentine

Rifapentine (MDL473) is an antibiotic, which inhibits DNA-dependent RNA polymerase activity, used to treat tuberculosis.

S1778

Trifluridine

Trifluridine (NSC 529182, NSC 75520) is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.

S1790

Rifaximin

Rifaximin is a RNA synthesis inhibitor by binding the β subunit of the bacterial DNA-dependent RNA polymerase, used to treat traveler's diarrhea caused by certain bacteria.

S1995

Procarbazine HCl

Procarbazine HCl (NSC-77213) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound, used for the treatment of Hodgkin's lymphoma.

S1784

Vidarabine

Vidarabine is an antiviral drug by interfering with the synthesis of viral DNA, used to treat herpes simplex and varicella zoster viruses.

S1764

Rifampin

Rifampin (Rimactane, Rifampicin) is a DNA-dependent RNA polymerase inhibitor, used to treat a number of bacterial infections.

S3001

Clevudine

Clevudine is an antiviral drug for the treatment of hepatitis B.

S1300

Tegafur (FT-207)

Tegafur (FT-207, NSC 148958) is a substance being used in the treatment of some types of cancer.

S1826

Nedaplatin

Nedaplatin is a derivative of cisplatin and DNA damage agent for tumor colony forming units with IC50 of 94 μM.

S7470

Triapine

Triapine (3-AP) is a potent ribonucleotide reductase (RNR) inhibitor with broad spectrum antitumor activity by inhibiting DNA synthesis. Phase 2.

S7757

6-Thio-dG

6-thio-dG is a nucleoside analog and telomerase substrate.

S4297

Mupirocin

Mupirocin is an isoleucyl t-RNA synthetase inhibitor, used in the treatment of bacterial skin infections.

S8376

Rbin-1

Rbin-1(ribozinoindole-1) is a potent chemical inhibitor of eukaryotic ribosome assembly. It inhibits recombinant full-length Mdn1's ATPase activity in vitro.

S5552

Amenamevir

Amenamevir is a potent helicase-primase inhibitor and a novel class of antiviral agent.

S8095

Tubercidin

Tubercidin (7-deaza-adenosine), an adenosine analogue, is a nucleoside antibiotic. It is incorporated into DNA and inhibits polymerases, thereby inhibiting DNA replication and RNA and protein synthesis. This agent also exhibits antifungal and antiviral activities.

S4035

Vitamin D2

Vitamin D2 is a selective inhibitor of mammalian DNA polymerase A (pol A) with IC50 of 123 μM.

S7975

Favipiravir (T-705)

Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections.

S8328

CeMMEC1 HCl

CeMMEC1 is an N-methylisoquinolinone derivative that inhibits the second bromodomain of TAF1 (IC50=0.9 μM).

S5484

Rimantadine Hydrochloride

Rimantadine is an RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza. It works by inhibiting a viral protein called M2, which normally mediates the transport of acid ions across the influenza virion shell.

S4504

6-Mercaptopurine (6-MP) Monohydrate

6-Mercaptopurine Monohydrate is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.

S7742

SCR7

SCR7 is a specific DNA Ligase IV inhibitor, which blocks nonhomologous end-joining (NHEJ).

S4737

Psoralen

Psoralen is a naturally occurring furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division.

S8146

Mitomycin C

Mitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.

S1973

Cyclocytidine HCl

Cyclocytidine (NSC 145668) is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia.

S3641

Osalmid

Osalmid suppresses ribonucleotide reductase (RR) activity in a concentration-dependent manner, with a 50% RR activity-inhibitory concentration (IC50) of 8.23 μM.

S7449

CRT0044876

CRT0044876 (NSC 69877, 7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM.

S7445

E3330

E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.

S5293

Nimustine Hydrochloride

Nimustine Hydrochloride (Nidran) is the hydrochloride salt of nimustine, a nitrosourea with antineoplastic activity that alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death.

S5297

Vidarabine monohydrate

Vidarabine is a nucleoside antibiotic with antiviral acitivity that interferes with the synthesis of viral DNA. It is used to treat herpes simplex and varicella zoster viruses.

S2794

Sofosbuvir (GS-7977)

Sofosbuvir (PSI-7977, GS-7977) is a HCV NS5B polymerase inhibitor for the treatment of chronic hepatitis C virus (HCV) infection.

S6115

Pyridoxal 5′-phosphate hydrate

Pyridoxal 5′-phosphate, a vitamin B6 phosphate, is a coenzyme in a variety of enzymatic reactions.

S8434

B02

B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM).

S8539

TAS-102

TAS-102 is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride.

S7637

DTP3

DTP3 is a selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor and is able to restore MKK7/JNK activation. DTP3 inhibits cancer-selective NF-κB survival pathway.

S8144

Halofuginone

Halofuginone is the competitively inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in mammal.

S3669

Carmustine

Carmustine (bis-chloroethylnitrosourea, BCNU, BiCNU) is a cell-cycle phase nonspecific alkylating antineoplastic agent and used in the treatment of brain tumors and various other malignant neoplasms.

S7679

YK-4-279

YK-4-279 is a potent inhibitor of EWS-FLI1 binding to RNA helicase A (RHA).

S4236

Proflavine Hemisulfate

Proflavine Hemisulfate is a topical antiseptic by interchelating DNA, thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands.

S7718

BMH-21

BMH-21 is a DNA intercalator, which binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription.

S4239

Bergapten

Bergapten is a psoralen that can be photoactivated and is capable of crossing-linking DNA, covalently modifying proteins and lipids, and consequently inhibiting cell replication.

S4782

5-methoxyflavone

5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity.

S4537

Oxolinic acid

Oxolinic acid is a quinolone antibiotic, inhibiting the enzyme DNA gyrase and DNA synthesis.It also acts as a dopamine reuptake inhibitor.

S7546

Pritelivir (BAY 57-1293)

Pritelivir (BAY 57-1293) is a potent helicase primase inhibitor, exhibiting antiviral effect on herpes simplex virus (HSV) with IC50 of 20 nM for both HSV-1 and HSV-2.

S8329

CeMMEC13

CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 µM).

S5582

Cytarabine hydrochloride

Cytarabine is a pyrimidine nucleoside analog that is used mainly in the treatment of leukemia. It is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA.

S7419

Blasticidin S HCl

Blasticidin S HCl is a nucleoside antibiotic isolated from Stretomyces girseochromogenes, and acts as a DNA and protein synthesis inhibitor, used to select transfected cells carrying bsr or BSD resistance genes.

S4288

Chloroambucil

Chlorambucil is a nitrogen mustard alkylating agent, used in the treatment of chronic lymphocytic leukemia.

S8246

RK-33

RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.

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S6893

PIN1 inhibitor API-1

PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor with IC50 of 72.3 nM. PIN1 inhibitor API-1 targets Pin1 peptidyl-prolyl isomerase domain and inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 up-regulates miRNA biogenesis by retaining active XPO5 conformation and suppresses HCC development.

S2427

Triglycidyl Isocyanurate (Teroxirone)

Triglycidyl Isocyanurate, also known as Teroxirone, is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry.

S8326

Saccharin 1-methylimidazole (SMI)

Saccharin 1-methylimidazole (SMI) is considered a general-purpose activator for DNA and RNA synthesis.

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S1334

Flupirtine maleate

Flupirtine maleate is the salt form of Flupirtine, which is a centrally acting non-opioid analgesia, is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.

2019, 17(7):310-321

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S7444

Pyridostatin Trifluoroacetate Salt

Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes.

2020, 22 pii: S1097-2765(20)30231-8

2020, 27;11(1):2661

2020, 18

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S1214

Bleomycin Sulfate

Bleomycin Sulfate (NSC125066) is a glycopeptide antibiotic and an anticancer agent for squamous cell carcinomas (SCC) with IC50 of 4 nM in UT-SCC-19A cells.

2020, 12(530)

2020, 22 pii: S1097-2765(20)30231-8

2020, 29;11(1):2086

S6854

Triazavirin

Triazavirin is a novel antiviral drug, a nucleoside analogue of nucleic acid that inhibits the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin is active against influenza and a number of other viruses. Triazavirin is an effective protective agent on the transmission stage of influenza.

S1237

Temozolomide

Temozolomide (CCRG81045, NSC 362856, TMZ) is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. A DNA damage inducer in L-1210 and L-1210/BCNU cells. Temozolomide induces apoptosis and exhibits antitumor activity.

2020, 580(7804):517-523.

2020, 580(7804):517-523

2020, 11(1):550

S1212

Bendamustine HCl

Bendamustine (SDX-105, Cytostasane) HCl is a DNA-damaging agent with IC50 of 50 μM in cell-free assay.

2020, 30;9(1):1758011

2020, 19;20:58

2020, 39(1):142

S1840

Lomustine

Lomustine (nsc79037, Gleostine, CeeNU, CCNU) inhibits cancer cells by damaging the DNA and stops cells from dividing.

2020, 580(7804):517-523.

2020, 19;20:58

2017, 15(1):133-150

S7918

Bromodeoxyuridine (BrdU)

Bromodeoxyuridine (BrdU) is a nucleoside analog that competes with thymidine for incorporation into DNA, and used in the detection of proliferating cells.

2020, 28;e12818

2019, 109:1951-1959

2018, 10.1016/j.biopha.2018.11.029

S4888

Guanine

Guanine is one of the four main nucleobases found in the nucleic acids DNA and RNA.

S5505

2’-deoxyuridine

2'-deoxyuridine is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms.

S6359

Purine

Purine is a heterocyclic aromatic organic compound which plays crucial roles in DNA and RNA. It is also significant components in a number of other important biomolecules, such as ATP, GTP, cyclic AMP, NADH, and coenzyme A.

S4194

Azaguanine-8

Azaguanine-8 is a purine analogs showing antineoplastic activity by competing with guanine in the metabolism.

2020, 19;20:58

S4803

Thymidine

Thymidine (Deoxythymidine, 2'-Deoxythymidine, 5-Methyldeoxyuridine) is a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose. As a constituent of DNA, thymidine pairs with adenine in the DNA double helix.

S1981

Adenine

Adenine is a purine derivative and a nucleobase with a variety of roles in biochemistry.

2020, 16;16(3):e1008341

S1983

Adenine HCl

Adenine HCl is a hydrochloride salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.

2020, 19;20:58

S1982

Adenine sulfate

Adenine sulfate is a sulfate salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.

S6077

Cytidine 5′-triphosphate (disodium salt)

Cytidine 5'-triphosphate is a pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions. It is used in the synthesis of RNA by RNA polymerases.

S5374

5'-Cytidylic acid

5'-Cytidylic acid (Cytidine monophosphate, Cytidine 5'-phosphate) is a nucleotide that is used as a monomer in RNA.

S5384

UTP, Trisodium Salt

Uridine-5'-triphosphate (UTP) is a pyrimidine nucleoside triphosphate and a substrate for the synthesis of RNA during transcription.

S3190

N6-methyladenosine (m6A)

N6-methyladenosine (m6A, NSC-29409) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs.

2020, 10.1038/s41588-020-0677-3

2019, 21(5):651-661

2019, 10(1):5126

S2029

Uridine

Uridine (NSC 20256) is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond.

S9382

Thymine

Thymine is one of the four nucleobases in the nucleic acid of DNA.