Pemetrexed (LY-231514) disodium

For research use only. Not for use in humans.

製品コードS1135

Pemetrexed (LY-231514) disodium化学構造

CAS No. 150399-23-8

Pemetrexed (LY-231514) disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.

サイズ 価格(税別)  
JPY 21900
JPY 80000
JPY 163000
最寄りの販売代理店を探す

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バルク問合せ

文献中Selleckの製品使用例(39)

製品安全説明書

DHFR阻害剤の選択性比較

生物活性

製品説明 Pemetrexed (LY-231514) disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.
ターゲット
TS [1]
(Cell-free assay)
DHFR [1]
(Cell-free assay)
GARFT [1]
(Cell-free assay)
1.3 nM(Ki) 7.2 nM(Ki) 65 nM(Ki)
体外試験

Pemetrexed disodium shows the antiproliferative activity in CCRF-CEM leukemia, GC3/C1 colon carcinoma, and HCT-8 ileocecal carcinoma cells with IC50 of 25 nM, 34 nM and 220 nM, respectively. [1] A recent study shows that cisplatin plus Pemetrexed combined with SOCS-1 gene delivery shows the antitumor effect by inhibition of cell proliferation, invasiveness, and induction of apoptosis in MPM cells infected with adenovirus-expressing SOCS-1 vector. [2]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PANC-1 MUHGeY5kfGmxbjDBd5NigQ>? M3zHOlg1KM7:TR?= M4e0T|I1KGh? NY\tRXlJ\W6qYX7j[ZMhTUeIUjygTGVTOyCjbnSgRWtVKHCqb4PwbI9zgWyjdHnvckBt\X[nbIO= MnzSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7N{e2NFcoRjJ{OUe3OlA4RC:jPh?=
BXPC-3 NV\tS|Y1TnWwY4Tpc44hSXO|YYm= NXLlV5dyOzlwOE[gJO69VQ>? NHHPPFYzPCCq NFf5NXdmdmijbnPld{BGT0[ULDDISXI{KGGwZDDBT3QheGixc4Doc5J6dGG2aX;uJIxmfmWucx?= MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl5N{[wO{c,OjJ7N{e2NFc9N2F-
PANC-1 MkThSpVv[3Srb36gRZN{[Xl? NHvIT2I5PCEQvF2= M1T3[FI1KGh? Mn3w[Y5p[W6lZYOgSWdHWiCyaH;zdIhwenmuYYTl[EBt\X[nbIOsJIFv\CC2aHWgdJJwfGWrbjDs[ZZmdHQEoB?= NUf0fGN6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5O|c3ODdpPkKyPVc4PjB5PD;hQi=>
BXPC-3 MVTGeY5kfGmxbjDBd5NigQ>? M2ryUFM6Njh4IDFOwG0> Moi1NlQhcA>? NEjJTI1mdmijbnPld{BGT0[UIIDoc5NxcG:{eXzheIVlKGyndnXsd{wh[W6mIITo[UBxem:2ZXnuJIxmfmWuc9Mg NEm0UmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mkm3O|YxPyd-MkK5O|c3ODd:L3G+
BXPC-3 MkC1SpVv[3Srb36gRZN{[Xl? MmLJN|kvQDZiIN88US=> M4jXTFI1KGh? NWq4cY5GcW6mdXPld{BUKGG{cnXzeEApWDxyLkC1LUBidmRiZHXjdoVie2W|IITo[UBvfW2kZYKgc4Yh[2WubIOgbY4hfGinIFeyM20heGijc3ZCpC=> MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl5N{[wO{c,OjJ7N{e2NFc9N2F-
PANC-1 NXLBWpM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fjSGlEPTB;OEOuO|bDuTBwMUmg{txO Ml;UQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7N{e2NFcoRjJ{OUe3OlA4RC:jPh?=
BXPC-3 Mmr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTN7Lki2xtEyNjZ6IN88US=> MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl5N{[wO{c,OjJ7N{e2NFc9N2F-
Jurkat MlrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHTOFghcA>? MYHwdo9xd3K2aX;uJI9nKGyrdnWgZ4VtdHN;N{[uO:KyPC5|IDW= MoXYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6NECzO|YoRjJ|OESwN|c3RC:jPh?=
DM-3 NHzXRmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7mOFghcA>? Mn\EdJJweG:{dHnvckBw\iCuaY\lJINmdGy|PUGwNU4{yrF{LkigKS=> M2HsUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OESwN|c3Lz5{M{i0NFM4PjxxYU6=
JL-1 Mn;JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrHNo81QCCq M{fhWZBzd3CxcoTpc44hd2ZibHn2[UBk\Wyuc{25PE4zyrF{LkKgKS=> MofpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6NECzO|YoRjJ|OESwN|c3RC:jPh?=
ZL-34 NGX0cHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTsfodvPDhiaB?= Mne1dJJweG:{dHnvckBw\iCuaY\lJINmdGy|PUm1MlfDuTZwNTCl NX3yN5F{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4OFA{PzZpPkKzPFQxOzd4PD;hQi=>
STAV-FCS NFXIU2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHHRlY1QCCq MkHWdJJweG:{dHnvckBw\iCuaY\lJINmdGy|PUi4MlHDuThwOTCl NFfCfFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i0NFM4Pid-MkO4OFA{PzZ:L3G+
M-14-K NXG1R4s{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfxSmhpPDhiaB?= Mmf2dJJweG:{dHnvckBw\iCuaY\lJINmdGy|PUixMljDuTF{LkmgKS=> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh2MEO3Okc,OjN6NECzO|Y9N2F-
STAV-AB M4DSO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LkNlQ5KGh? NH3Ub4xxem:yb4L0bY9vKG:oIHzpeoUh[2WubIO9OlQvPMLzMkGuPEAm M3TKeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OESwN|c3Lz5{M{i0NFM4PjxxYU6=
LoVo NUG2W3RzTnWwY4Tpc44hSXO|YYm= M1LLOFAvODYEoN88US=> NEjmXYU4OsLiaB?= NV[4bpYyTE2VT9Mg M4rm[olv[3KnYYPld{B1cGVicHXyZ4VvfGGpZTDv[kBk\WyuczDpckB1cGViUzDwbIF{\cLi M12ze|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUW5OFYxLz5{M{m1PVQ3ODxxYU6=
HT-29 MVLGeY5kfGmxbjDBd5NigQ>? MoHINE4xPcLizszN NFK2d2k4OsLiaB?= M1XJVmROW00EoB?= Ml;MbY5kemWjc3XzJJRp\SCyZYLj[Y51[WenIH;mJINmdGy|IHnuJJRp\SCVIIDoZZNmyqB? M2\xRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUW5OFYxLz5{M{m1PVQ3ODxxYU6=
WiDr MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYq3NuKhcMLi NYLue4o2TE2VT9Mg MkLjTWM2OD1yLkCxPUDDuSByLkCwNkDPxE1? MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl3OUS2NEc,OjN7NUm0OlA9N2F-
SW1116 M1naZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVe3NuKhcMLi NGDUR|dFVVORwrC= M2H1OGlEPTB;MT63NEDDuSByLkCzJO69VQ>? MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl3OUS2NEc,OjN7NUm0OlA9N2F-
HCT116 NGTJb5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml63O|LDqGkEoB?= MYHEUXNQyqB? NU\0RW5vUUN3ME2wMlA1QSEEsTCwMlAyOyEQvF2= NUXPRXFXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OVk1PjBpPkKzPVU6PDZyPD;hQi=>
SW620 Mnn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYKwWYVSPzMEoHlCpC=> NVjMVHlETE2VT9Mg MU\JR|UxRTFwMEmgxtEhOC5yMTFOwG0> MknLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NUm0OlAoRjJ|OUW5OFYxRC:jPh?=
LoVo NUHFbWFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;3[FczyqCqwrC= NYjGe4I4TE2VT9Mg NX7XTmo2UUN3ME2wMlA{OiEEsTCwMlAxOiEQvF2= NIDKOGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m1PVQ3OCd-MkO5OVk1PjB:L3G+
HT-29 NH\XfWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\BV|czyqCqwrC= M3f0[WROW00EoB?= NHrq[nFKSzVyPUGwMlA4KMLzIECuPVQh|ryP MmfsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NUm0OlAoRjJ|OUW5OFYxRC:jPh?=
A549/PEM-16 MnrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3JPVYhcA>? MofSTWM2OD13MT60OUDPxE1? NITJfIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO0PFg2PCd-MkSzOFg5PTR:L3G+
A549/PEM-6.4 NHi0NoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HHXVk3KGh? MnHyTWM2OD1{Mz6zPUDPxE1? NWnSNmN6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzOFg5PTRpPkK0N|Q5QDV2PD;hQi=>
A549/PEM-1.6 M3rFeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3r2d|k3KGh? MnzWTWM2OD13LkCzJO69VQ>? Mlu2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|NEi4OVQoRjJ2M{S4PFU1RC:jPh?=
A549 MornS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVy5OkBp M1\HZmlEPTB;MT6zOUDPxE1? NF\5VHE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO0PFg2PCd-MkSzOFg5PTR:L3G+
MSTO-211H MoX6R4VtdCCYaXHibYxqfHliQYPzZZk> MoDnNU0yOCEQvHevcYw> MXS3NkBp MVrJR|UxhjBwMESg{txoN22u NXnkdopzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzO|g2PzZpPkK0N|c5PTd4PD;hQi=>
Y-meso14 MYfD[YxtKF[rYXLpcIl1gSCDc4PhfS=> M{XxZlEuOTBizsznM41t MlnvO|IhcA>? MWjJR|UxRjFyIN88[{9udA>? NW\GfXpwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzO|g2PzZpPkK0N|c5PTd4PD;hQi=>
H290 MnjBR4VtdCCYaXHibYxqfHliQYPzZZk> NGnwTnUyNTFyIN88[{9udA>? MYG3NkBp M{\2c2lEPTB-MUCg{txoN22u M3PPUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{e4OVc3Lz5{NEO3PFU4PjxxYU6=
H226 MkTKR4VtdCCYaXHibYxqfHliQYPzZZk> MXKxMVExKM7:Zz;tcC=> Ml3mO|IhcA>? MmHaTWM2OD5zMDFOwIcwdWx? NY\Nbpc4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzO|g2PzZpPkK0N|c5PTd4PD;hQi=>
H1299 NXzpVY5MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPqR|hSUUN3ME2xMlg1KM7:TR?= M3T5[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEG4OVE6Lz5{NESxPFUyQTxxYU6=
H1993 NVn4eFU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\KRmhKSzVyPUCuNVch|ryP NXj3SmRoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0NVg2OTlpPkK0OFE5PTF7PD;hQi=>
A549 NULFdYN{TnWwY4Tpc44hSXO|YYm= Mn\NNE4yNzBwMz:wMlUwOSEQvF2= MUSyOE81QCCq MX;EUXNQ MXvwdo9lfWOnczD0bIUh\m:{bXH0bY9vKG:oIFHWU5MhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> Mmr3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4Mk[3NlIoRjJ2NkK2O|IzRC:jPh?=
A549 MYLD[YxtKF[rYXLpcIl1gSCDc4PhfS=> M1HRXlAvOS9yLkOvNE42NzFizszN NF3QRnozPC92ODDo NFvBd5hFVVOR MnKwbY5pcWKrdIOgZ4VtdCC4aXHibYxqfHliZH;z[UBidmRidHnt[UBl\XCnbnTlcpRtgQ>? MlzQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4Mk[3NlIoRjJ2NkK2O|IzRC:jPh?=
MES04 NI\jcHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEm4SpdKSzVy78{eNVAxKM7:TR?= M1nB[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{G0O|IzLz5{NEexOFczOjxxYU6=
MES01 NWf6VXRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPJT|EzUUN3MP-8olExOCEQvF2= NIT5cVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEexOFczOid-MkS3NVQ4OjJ:L3G+
H2452 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|Ux97zgMUCwJO69VQ>? NGPnTmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEexOFczOid-MkS3NVQ4OjJ:L3G+
H2052 NVi2TJV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmezTWM2OD1yLkW3xtExNjN2IN88US=> M{\SclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{G0O|IzLz5{NEexOFczOjxxYU6=
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PC9/GR M{n2bmZ2dmO2aX;uJGF{e2G7 MnzvOE46PCEQvF2= NEXkfIE4OiCq NIH4PGxqdmO{ZXHz[ZMheC2DS2SgcIV3\Wy| NELNdWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi0NFg6OSd-MkS4OFA5QTF:L3G+
PC9/GR MmPPSpVv[3Srb36gRZN{[Xl? M3XYflQvQTRizszN NXO1VHhXPzJiaB?= M2i4bolv[3KnYYPld{BxNUWUSzDs[ZZmdHN? NULCTHk3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4OFA5QTFpPkK0PFQxQDlzPD;hQi=>
PC9/GR M2PVO2Fxd3C2b4Ppd{BCe3OjeR?= MYO0Mlk1KM7:TR?= MUm3NkBp Mmr6bY5lfWOnczCxPU42PO,7qjDhdI9xfG:|aYO= NV3YXZQ2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4OFA5QTFpPkK0PFQxQDlzPD;hQi=>
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A549 MUfGeY5kfGmxbjDBd5NigQ>? NHiyV3YxNjFxMD6zM|Eh|ryP NXLQNHBiPDhiaB?= NU\TOoducW6lcnXhd4V{KHSqZTDyZZRqdyCxZjDTMZBp[XOnIIDvdJVt[XSrb36= NXrLOI1WRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4OFc5PjNpPkK0PFQ4QDZ|PD;hQi=>
A549 MWDBdI9xfG:|aYOgRZN{[Xl? NEPkbJExNjFxMD6zM|Eh|ryP NFvZPFQ1QCCq MlrhbY5lfWOnczDhdI9xfG:|aYOgbY4h[SCmb4PlJIRmeGWwZHXueEBu[W6wZYK= Mo\NQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6NEe4OlMoRjJ2OES3PFY{RC:jPh?=
A549 NGHqcYtHfW6ldHnvckBCe3OjeR?= MUewMlEwOC5|L{Gg{txO MkjhOFghcA>? MnjybY5kemWjc3XzJJRp\SCuZY\lcEBw\iCyaH;zdIhwenmuYYTl[EBCc3RiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? Ml21QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6NEe4OlMoRjJ2OES3PFY{RC:jPh?=
A549 MVvGeY5kfGmxbjDBd5NigQ>? Mli2NUDDvU1? MUC0M|gwOTJxMkSvOFghcA>? M3:2Tolv[3KnYYPld{B1cGVibHX2[Ywhd2ZicHjvd5Bpd3K7bHH0[YQhSWu2IHnuJIEhfGmvZTDk[ZBmdmSnboSgcYFvdmW{ MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh2N{i2N{c,OjR6NEe4OlM9N2F-
A549 NEPBNGxHfW6ldHnvckBCe3OjeR?= NETINoc2KM7:TR?= NUjUb3FIQCCq MWPpcoNz\WG|ZYOgUYNtNTFidXLpdZVqfGmwYYTpc44hdGW4ZXzz MmmwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7OUG3OlgoRjJ2OUmxO|Y5RC:jPh?=
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A549  Mln6SpVv[3Srb36gRZN{[Xl? M3rmXlIvPS93L{GwJO69VQ>? MmHBOFghcA>? M4rGN4Rwf26{ZXf1cIF1\XNiTXPsMVHDqA>? MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl7MUe2PEc,OjR7OUG3Olg9N2F-
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A549  M1TEUGZ2dmO2aX;uJGF{e2G7 NIHmTI4zNjVizszN M4\YOlQ5KGh? NFTDTFZqdmS3Y3XzJINie3Cjc3WtPUwh[2G|cHHz[U0{KGGwZDDwc4x6KCiDRGCtdoljd3OnKTDwc4x6dWW{YYPlJEhRSVKSKTDjcIVifmGpZR?= NGD3XWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm5NVc3QCd-MkS5PVE4Pjh:L3G+
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H1299 M1;MXWNmdGxiVnnhZoltcXS7IFHzd4F6 MlrENU0yODByIH7N NIex[JM4OiCq NYnme3k4UUN3ME2xO|ghdk1? MofvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVzNEW2OlkoRjJ3MUS1OlY6RC:jPh?=
A549 NVL5T2JWS2WubDDWbYFjcWyrdImgRZN{[Xl? NEWzb4UyNTFyMECgcm0> NWqy[2k5PzJiaB?= NXGxNHVYUUN3ME2xN|chdk1? NV:wN|lPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWxOFU3PjlpPkK1NVQ2PjZ7PD;hQi=>
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HepG3 MnHZSpVv[3Srb36gRZN{[Xl? Ml7zNVDDqM7:TR?= NVm5cHpVPDhiaB?= MWP1dJJm\3WuYYTld{BxcG:|cHjvdplt[XSnZDCodE0qKE2HS{GvNkApW2W{MkG3M|IzOSliYX7kJJAuTVKNMT:yJEhVcHJ{MEKvWJlzOjB2KR?= NIHzRYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS0OlExOid-MkW0OFYyODJ:L3G+
HepG3 M4SyUGZ2dmO2aX;uJGF{e2G7 NWTxN3JoOC5z4pETNVAxyqEQvF2= MXS0PEBp M2XDS4FkfGm4YYTld{BkgXSxLYDyc5Rm[3SrdnWgZZV1d3CqYXf5xsA> M17NTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NES2NVAzLz5{NUS0OlExOjxxYU6=
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アッセイ
Methods Test Index PMID
Western blot
p-Chk1 / Chk1 / Cyclin D / Cyclin E / p-Histone H3 / Histone H3 / Cyclin B1 / p-Cdc2 / Cdc2 ; 

PubMed: 22237209     


Protein alterations in the response to DNA damage, cell cycle progression, and cell death were detected in (c) UDG−/− cells and (d) UDG+/+ cells treated with pemetrexed. Cells were collected at 6 and 24 h after pemetrexed treatment. Results are representative of two independent experiments.

Topo IIα / Topo I / γH2AX / Cleaved PARP / Survivin; 

PubMed: 22237209     


Protein alterations involved in regulation of apoptotic cell death were detected in (c) UDG−/− cells and (d) UDG+/+ cells treated with pemetrexed. Cells were collected at 6 and 24 h after pemetrexed treatment. Results are representative of two independent experiments.

AKT / p-AKT / GSK3β / p-GSK3β ; 

PubMed: 24847863     


Akt activation in a time course dependent manner. Human lung adenocarcinoma A549 cells were treated without or with 1 µM pemetrexed for 0, 4, 8, 12, 24, and 48 h, and then cell lysates were isolated. After treatment, the levels of total Akt, phosphorylated Akt, total GSK3β, and phosphorylated GSK3β were examined by Western blot analysis. β-Actin was used as an internal loading control. 

EGFR / p-EGFR ; 

PubMed: 30953548     


After treatment with incremental exposure time of pemetrexed. The total and phosphorylated EGFR, AKT, and MAPK proteins in PC-9 cells were detected by Western blot. GAPDH served as the loading control. 

22237209 24847863 30953548
Immunofluorescence
p-AKT; 

PubMed: 24847863     


A549 cells were treated with 0, 0.1, 0.3, and 1 µM pemetrexed for 48 h. After treatment, the subcellular distribution of p-AktS473 was detected by confocal microscopy after immunostaining with anti-phospho-AktS473 and Rhodamine-conjugated secondary antibody. Hoechst 33342 was used to counter stain nuclei, and the images were overlaid to determine the Akt localization within the cell.

24847863
Growth inhibition assay
Cell viability; 

PubMed: 28719077     


Effects of metformin and (or) pemetrexed on the proliferation of human NSCLC cell lines. (A) Antiproliferative effects of metformin on NSCLC cells. (B) Effects of pemetrexed on the proliferation of the three tested cell lines. (C) Metformin in combination with pemetrexed inhibits the proliferation of the tested cells. (D–F) Effects of metformin and (or) pemetrexed on the proliferation of A549(D), HCC827(E), and H1975(F) cell lines. (G–I) Strengthening antiproliferative effects of metformin in combination with pemetrexed on A549(G), HCC827(H), H1975(I) cell lines,*P < 0.05. Metf represents metformin; Pem represents pemetrexed.

28719077
体内試験 In the human H460 non-small cell lung carcinoma xenograft, Pemetrexed disodium produces a duration-dependent tumor growth delay (TGD). [3]

お薦めの試験操作(参考用のみ)

キナーゼ試験:[1]
- 合併

Enzyme Assays and Methods. :

TS activity is assayed using a spectrophotometric method, which involved monitoring the increase in absorbance at 340 nm resulting from formation of the product, 7,8-dihydrofolate. The assay buffer contains 50 mM N-tris[hydroxymethyljmethyl-2-aminoethanesulfonic acid, 25 mM MgC12, 6.5 mM formaldehyde, 1 mM EDTA, and 75 mM 2-mercaptoethanol, pH 7.4. The concentrations of deoxyuridylate monophosphate, 6R-MTHF, and hIS are 100 μM, 30μM and 30 nM (1.7 milliunits/mL), respectively. At the 6R-MTHF concentration, an uninhibited reaction and six concentrations of inhibitor are assayed. Ki app values are determined by fitting the data to the Morrison equation using nonlinear regression analysis with the aid of the program ENZFITTER. Ki values are calculated using the equation: Ki app= Ki(1 + [S]/Km), where [S] is equal to 30 μM and Km is equal to 3 μM. DHFR activity is assayed spectrophotometrically by monitoring the dis appearance of the substrates NADPH and 7,8-dihydrofolate at 340 nm. The reaction takes place at 25°C in 0.5 mL of 50 mM potassium phosphate buffer, which contains 150 mM KC1 and 10 nM 2-mercaptoethanol, pH 7.5, and 14 nM (0.34 milliunitlmL) DHFR. The NADPH concentration is 10 μM and 7,8-dihydrofolate is varied at 5, 10, or 15 μM. At each 7,8-dihydrofolate concentration, an uninhibited reaction and seven concentrations of inhibitor are assayed. The ENZFITI'ER microcomputer program is used to obtain Ki app values by fitting the data to the Morrison equation by nonlinear regression analysis. Ki app= Ki(1 + [S]/Km), where [S] is equal to the concentration of 7,8-dihydrofolate used and Km of 7,8-dihydrofolate is equal to 0.15 μM. GARFT activity is assayed spectrophotometrically by monitoring the increase of absorbance resulting from formation of the product 5,8-dideazafolate at 295 nm. The reaction solvent contains 75 mM HEPES, 20% glycerol, and 50 mM a-thioglygerol, pH 7.5, at 25°C. The concentrations of substrates and enzyme used are 10 μM α,β-glycinamide ribonucleotide, 0-10 μM 10-formyl-5,8-dideazafolic acid, and 10 nM (1.9 milliunits/mL) GARFT. Ki values are calculated using the Enzyme Mechanism program of the Beckman DU640 spectrophotometer, which uses nonlinear regression analysis to fit data to the Michaelis-Menten equation for competitive inhibition.
細胞試験: [1]
- 合併
  • 細胞株: CCRF-CEM leukemia, GC3/C1 colon carcinoma, and HCT-8 ileocecal carcinoma cells.
  • 濃度: 0-30 μM
  • 反応時間: 72 hours
  • 実験の流れ: Dose-response curves are generated to determine the concentration required for 50% inhibition of growth (IC50). Pemetrexed disodium is dissolved initially in DMSO at a concentration of 4 mg/mL and further diluted with cell culture medium to the desired concentration. CCRF-CEM leukemia cells in complete medium are added to 24-well Cluster plates in a total volume of 2.0 mL. Pemetrexed disodium at various concentrations are added to duplicate wells so that the final volume of DMSO is 0.5%. The plates are incubated for 72 hour at 37 °C in an atmosphere of 5% CO2 in air. At the end of the incubation, cell numbers are determined on a ZBI Coulter counter. For several studies, IC50s are determined for each compound in the presence of either 300 μM AICA, 5 μM thymidine, 100 μM hypoxanthine, or combination of 5 μM hymidine plus 100 μM hypoxanthine. For adherent tumor cells, a modification of the original MTT colorimetric assay is used to measure cell cytotoxicity. The human tumor cells are seeded in 100 μL assay medium/well in 96-well flat-bottomed tissue culture plates. The assay medium contains folic acid-free RPMI 1640 supplemented with 10% FCS and either 2 nM folinic acid or 2.3 μM folic acid as the sole folate source. Well 1A is left blank. Stock solutions of antifolates are prepared in Dulbecco's PBS at 1 mg/mL, and a series of 2-fold dilutions are subsequently made in PBS. Ten-μL aliquots of each concentration are added to triplicate wells. Plates are incubated for 72 hours at 37 °C in a humidified atmosphere of 5% CO2-in-air. MTT is dissolved in PBS at 5 mg/mL, 10 μL of stock MTF solution are added to each well of an assay, and the plates are incubated at 37 °C for 2 additional hours. Following incubation, 100 μL of DMSO are added to each well. After thorough formazan solubilization, the plates are read on a Dynatech MR600 reader, using a test wavelength of 570 nm and a reference wavelength of 630 nm. The IC50 is determined as the concentration of drug required to inhibit cell growth by 50% compared to an untreated controls.
    (参考用のみ)
動物試験:[3]
- 合併
  • 動物モデル: EMT-6 mammary carcinoma, the human HCT 116 colon carcinoma, and the human H460 non-small cell lung carcinoma are injected s.c. into the nude mice.
  • 投薬量: 100 mg/kg or 150 mg/kg
  • 投与方法: Administered via i.p.
    (参考用のみ)

溶解度 (25°C)

体外 Water 94 mg/mL (199.41 mM)
DMSO Insoluble
Ethanol Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
Saline
混合させたのち直ちに使用することを推奨します。
30 mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 471.37
化学式

C20H19N5Na2O6

CAS No. 150399-23-8
Storage powder
in solvent
別名 N/A
Smiles C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]

投与溶媒組成計算器(クリア溶液)

ステップ1:実験データを入力してください。(実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します)
投与量 mg/kg 動物平均体重 g 投与体積(動物毎) ul 動物数
ステップ2:投与溶媒の組成を入力してください。(ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください)
% DMSO % % Tween 80 % ddH2O
計算リセット

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (mg) = 濃度 (mM) x 体積 (mL) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04173338 Recruiting Drug: Cabozantinib|Drug: Pemetrexed Non Small Cell Lung Cancer|Non-squamous Non-small-cell Lung Cancer|Urothelial Carcinoma|Malignant Mesothelioma Augusta University January 23 2020 Phase 1
NCT03023319 Recruiting Drug: Bosutinib|Drug: Pemetrexed Carcinoma Non-Small-Cell Lung|Mesothelioma|Bladder Cancer|Ovarian Cancer|Peritoneal Cancer|Thymoma|Thymus Cancer|Uterine Cervical Cancer Nagla Abdel Karim|Augusta University December 10 2019 Phase 1

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

DHFRシグナル伝達経路

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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID