S1210 |
Methotrexate
|
Methotrexate, analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis. |
-
Clin Transl Med, 2024, 14(2):e1586
-
iScience, 2024, 27(1):108667
-
EMBO Mol Med, 2023, 15(12):e18199
|
|
S1135 |
Pemetrexed disodium
|
Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis. |
-
Cancer Cell, 2022, 40(10):1128-1144.e8
-
Cell Rep, 2022, 38(9):110448
-
Front Pharmacol, 2022, 13:1032975
|
|
S7785 |
Pemetrexed Disodium Hydrate
|
Pemetrexed Disodium Hydrate (LY-231514) is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. Pemetrexed Disodium Hydrate stimulates autophagy and apoptosis. |
-
Cell Rep, 2022, 38(9):110448
-
Front Pharmacol, 2022, 13:1032975
-
J Pers Med, 2022, 12(2)258
|
|
S5971 |
Pemetrexed
|
Pemetrexed (LY231514) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis. |
-
Mol Cancer Res, 2024, 22(1):82-93
-
Amino Acids, 2024, 56(1):15
-
Cell Death Dis, 2023, 10.1038/s41419-023-06240-x
|
|
S5097 |
Methotrexate disodium
|
Methotrexate disodium, an analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis. |
-
Chin Med J (Engl), 2023, 10.1097/CM9.0000000000002816
-
Pharmaceutics, 2023, 15(2)576
-
Bioact Mater, 2022, 18:459-470
|
|
S1497 |
Pralatrexate
|
Pralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines. Pralatrexate induces tumor cell apoptosis. |
-
Cancer Cell, 2023, 41(4):660-677.e7
-
J Pers Med, 2022, 12(2)258
-
Hum Cell, 2022, 10.1007/s13577-022-00671-y
|
|
S2006 |
Pyrimethamine
|
Pyrimethamine(RP 4753) is a dihydrofolate reductase (DHFR) inhibitor, used as an antimalarial drug. |
-
BMC Cancer, 2024, 24(1):116
-
Pharmaceuticals (Basel), 2023, 16(3)447
-
Mol Biol Rep, 2022, 10.1007/s11033-022-07262-y
|
|
S1236 |
Leucovorin (Folinic acid) Calcium Pentahydrate
|
Leucovorin (Folinic acid) Calcium Pentahydrate is a derivative of folic acid, which can be used to increase levels of folic acid under conditions favoring folic acid inhibition.Solutions are unstable and should be fresh-prepared. |
-
Cell Rep Med, 2023, 4(10):101200
-
Cell Rep Med, 2023, S2666-3791(23)00367-1
-
J Hepatocell Carcinoma, 2023, 10:483-495
|
|
S5927 |
Proguanil
|
Proguanil (chlorguanide, chloroguanide) is a prophylactic antimalarial drug. It inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication. |
-
Int J Med Sci, 2022, 19(2):233-241
-
Sci Adv, 2021, 7(27)eabh3032
|
|
S2588 |
Calcium Levofolinate
|
Calcium Levofolinate (Calcium Folinate, Levoleucovorin calcium, CL307782,L-Leucovorin calcium) is a calcium salt of folinic acid that is an adjuvant used in cancer chemotherapy.Solutions are unstable and should be fresh-prepared. |
-
Drug Resist Updat, 2023, 71:101005
|
|
S3129 |
Trimethoprim
|
Trimethoprim (BW 56-72, NIH 204, NSC-106568) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections. |
|
|
E1003 |
Aminopterin
|
Aminopterin (4-amino Folic Acid, 4-amino PGA, 4-Aminofolic acid, 4-Aminopteroylglutamic acid, Aminopteroylglutamic acid, APGA, NSC 739), a folic acid antagonist, is a competitive inhibitor of dihydrofolate reductase (DHFR) with Ki of 3.7 pM.
|
-
Mol Cancer Res, 2024, 22(1):82-93
|
|
S5200 |
Diaveridine
|
Diaveridine (AI3-23935, CCRIS-3784) is coccidiostat with anti-parasitic activity and also a dihydrofolate reductase (DHFR) inhibitor preventing folic acid synthesis in species of Pneumocystis. |
|
|
S5136 |
Calcium folinate (Leucovorin calcium)
|
Calcium folinate (Leucovorin calcium) is a metabolically active, reduced form of folic acid that is rapidly absorbed and extensively metabolized in the liver to other folic acid derivatives.Solutions are unstable and should be fresh-prepared. |
|
|
S1210 |
Methotrexate
|
Methotrexate, analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis. |
- Clin Transl Med, 2024, 14(2):e1586
- iScience, 2024, 27(1):108667
- EMBO Mol Med, 2023, 15(12):e18199
|
|
S1135 |
Pemetrexed disodium
|
Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis. |
- Cancer Cell, 2022, 40(10):1128-1144.e8
- Cell Rep, 2022, 38(9):110448
- Front Pharmacol, 2022, 13:1032975
|
|
S7785 |
Pemetrexed Disodium Hydrate
|
Pemetrexed Disodium Hydrate (LY-231514) is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. Pemetrexed Disodium Hydrate stimulates autophagy and apoptosis. |
- Cell Rep, 2022, 38(9):110448
- Front Pharmacol, 2022, 13:1032975
- J Pers Med, 2022, 12(2)258
|
|
S5971 |
Pemetrexed
|
Pemetrexed (LY231514) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis. |
- Mol Cancer Res, 2024, 22(1):82-93
- Amino Acids, 2024, 56(1):15
- Cell Death Dis, 2023, 10.1038/s41419-023-06240-x
|
|
S5097 |
Methotrexate disodium
|
Methotrexate disodium, an analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis. |
- Chin Med J (Engl), 2023, 10.1097/CM9.0000000000002816
- Pharmaceutics, 2023, 15(2)576
- Bioact Mater, 2022, 18:459-470
|
|
S1497 |
Pralatrexate
|
Pralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines. Pralatrexate induces tumor cell apoptosis. |
- Cancer Cell, 2023, 41(4):660-677.e7
- J Pers Med, 2022, 12(2)258
- Hum Cell, 2022, 10.1007/s13577-022-00671-y
|
|
S2006 |
Pyrimethamine
|
Pyrimethamine(RP 4753) is a dihydrofolate reductase (DHFR) inhibitor, used as an antimalarial drug. |
- BMC Cancer, 2024, 24(1):116
- Pharmaceuticals (Basel), 2023, 16(3)447
- Mol Biol Rep, 2022, 10.1007/s11033-022-07262-y
|
|
S5927 |
Proguanil
|
Proguanil (chlorguanide, chloroguanide) is a prophylactic antimalarial drug. It inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication. |
- Int J Med Sci, 2022, 19(2):233-241
- Sci Adv, 2021, 7(27)eabh3032
|
|
S2588 |
Calcium Levofolinate
|
Calcium Levofolinate (Calcium Folinate, Levoleucovorin calcium, CL307782,L-Leucovorin calcium) is a calcium salt of folinic acid that is an adjuvant used in cancer chemotherapy.Solutions are unstable and should be fresh-prepared. |
- Drug Resist Updat, 2023, 71:101005
|
|
S3129 |
Trimethoprim
|
Trimethoprim (BW 56-72, NIH 204, NSC-106568) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections. |
|
|
E1003 |
Aminopterin
|
Aminopterin (4-amino Folic Acid, 4-amino PGA, 4-Aminofolic acid, 4-Aminopteroylglutamic acid, Aminopteroylglutamic acid, APGA, NSC 739), a folic acid antagonist, is a competitive inhibitor of dihydrofolate reductase (DHFR) with Ki of 3.7 pM.
|
- Mol Cancer Res, 2024, 22(1):82-93
|
|
S5200 |
Diaveridine
|
Diaveridine (AI3-23935, CCRIS-3784) is coccidiostat with anti-parasitic activity and also a dihydrofolate reductase (DHFR) inhibitor preventing folic acid synthesis in species of Pneumocystis. |
|
|
S5136 |
Calcium folinate (Leucovorin calcium)
|
Calcium folinate (Leucovorin calcium) is a metabolically active, reduced form of folic acid that is rapidly absorbed and extensively metabolized in the liver to other folic acid derivatives.Solutions are unstable and should be fresh-prepared. |
|
|