DHFR
シグナル伝達経路
研究分野
- 阻害剤の選択性比較
- 溶解度
| カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | アルコール | ||
| S1135 | Pemetrexed | 94 mg/mL | <1 mg/mL | <1 mg/mL |
| S1210 | Methotrexate | <1 mg/mL | 90 mg/mL | <1 mg/mL |
| S1497 | Pralatrexate | <1 mg/mL | 28 mg/mL | <1 mg/mL |
| S2006 | Pyrimethamine | <1 mg/mL | 10 mg/mL | <1 mg/mL |
| S1618 | Sulfameter | <1 mg/mL | 56 mg/mL | <1 mg/mL |
| S5097 | Methotrexate disodium | 99 mg/mL | <1 mg/mL | -1 mg/mL |
| S5200 | Diaveridine | -1 mg/mL | 25 mg/mL | -1 mg/mL |
| S7785 | Pemetrexed Disodium Hydrate | 100 mg/mL | <1 mg/mL | <1 mg/mL |
- DHFR阻害剤(8)
- 新DHFR製品
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S1135 |
PemetrexedPemetrexed is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. |
Role of PARP and BER in the synergy between PTX and GMX in A549 cells. Cells were pretreated ±1 umol/L olaparib (2 hours) then sequentially ±150 nmol/L PTX (24 hours), then ± GMX 12 nmol/L (48 hours). PAR modification of proteins and γ-H2AX levels were measured in extracts treated as in A by Western blotting.
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| S1210 |
MethotrexateMethotrexate (MTX), analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. |
A. Viability comparison of REH vector control, BCL6 overexpression, or BCL6 overexpression cells pre-treated with 79-6 (125μM) following exposure to three chemotherapy drugs (Ara-C [1 μM], MTX [50 μM], VCR [25 μM]). (* = p < 0.05 BCL6 OX to vector control and # = p < 0.05 BCL6 OX to BCL6 + 79-6).
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| S1497 |
PralatrexatePralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines. |
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| S2006 |
PyrimethaminePyrimethamine is a dihydrofolate reductase (DHFR) inhibitor, used as an antimalarial drug. |
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| S1618 |
SulfameterSulfameter is a long-acting sulfonamide antibacterial. |
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| S5097新 |
Methotrexate disodiumMethotrexate sodium, an inhibitor of tetrahydrofolate dehydrogenase, is an antineoplastic antimetabolite with immunosuppressant properties. |
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| S5200新 |
DiaveridineDiaveridine is coccidiostat with anti-parasitic activity and also a dihydrofolate reductase (DHFR) inhibitor preventing folic acid synthesis in species of Pneumocystis. |
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| S7785 |
Pemetrexed Disodium HydratePemetrexed Disodium Hydrate is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. |
Role of PARP and BER in the synergy between PTX and GMX in A549 cells. Cells were pretreated ±1 umol/L olaparib (2 hours) then sequentially ±150 nmol/L PTX (24 hours), then ± GMX 12 nmol/L (48 hours). PAR modification of proteins and γ-H2AX levels were measured in extracts treated as in A by Western blotting.
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