FDA-approved & Passed Phase I Drug Library

目录号 L3800

A unique collection of 2879 drugs that are marketed around the world or that have passed phase 1 clinical trials for high throughput screening (HTS) and high content screening (HCS).

サイズ

価格(税別)

予めDMSOまたは水に溶解しています
100uL/well (2mM or 10mM solution)	3190300
2x100uL/well (2mM or 10mM solution)	5103200

最寄りの販売代理店を探す

東京
北海道
東北
北関東
南関東
東海
北信越
近畿
中国
四国
九州

お探しのディーラーが見当たらない場合は直接こちらのメールアドレスまでお問い合わせください：[email protected]

具体的な在庫状況を確認してください。代表番号: 03-5615-9297 | 電子メール：[email protected]

セレックの化合物ライブラリーはCOVID19研究に貢献しています

(日本)国立感染症研究所はセレックのFDA承認化合物を用いてスクリニーング実験を行い、研究から僅か3ヶ月以内にCOVID19
の治療薬候補を見出しました。本研究成果はBioRxivにて発表されました。doi: 10.1101/2020.04.14.039925。

本研究成果はテレビニュース等での報道も行われました

お気に入りの分子或いは調達サービスにより、分子ライブラリーをカスタマイズします。
お客様自身のニーズを満たすために、弊社の製品を数量、状態（乾燥状態/固体或いはDMSO）等で選択できます。

FDA-approved & Passed Phase I Drug Library内容

Download theFDA-approved & Passed Phase I Drug Library - SDF

Download theFDA-approved & Passed Phase I Drug Library - XLSX

Download the Compound Library Usage Instructions- PDF

Selleckの分子ライブラリーが使用されている文献(73)

Cell Metab,2019,7;29(5):1166-1181.e6.

PubMed: 30799286 ( click the link to review the publication )

Nat Med,2014,20(8):954-60

PubMed: 24997607 ( click the link to review the publication )

Nat Commun,2020,14;11(1):1792.

PubMed: 32286289 ( click the link to review the publication )

Cancer Res,2020,15;80(4):832-842.

PubMed: 31888889 ( click the link to review the publication )

Stem Cell Reports,2020,14(3):478-492

PubMed: 32084387 ( click the link to review the publication )

Cancer Lett,2020,469:195-206

PubMed: 31672491 ( click the link to review the publication )

Cell Death Dis,2020,2;11(3):158.

PubMed: 32123161 ( click the link to review the publication )

Signal Transduct Target Ther,2020,4;5:20.

PubMed: 32195002 ( click the link to review the publication )

Mol Ther Oncolytics,2020,30;17:169-179.

PubMed: 32346607 ( click the link to review the publication )

Cell Chem Biol,2020,20;27(2):197-205.e6.

PubMed: 31734178 ( click the link to review the publication )

Cell Chem Biol,2020,16;27(1):94-104.e5.

PubMed: 31902676 ( click the link to review the publication )

Antimicrob Agents Chemother,2020,4;AAC.02523-19.

PubMed: 32366713 ( click the link to review the publication )

Toxicol Sci,2020,1;174(2):218-240.

PubMed: 32040181 ( click the link to review the publication )

Int J Mol Sci,2020,18;21(8):2825.

PubMed: 32325639 ( click the link to review the publication )

Sci Rep,2020,24;10(1):5318.

PubMed: 32210281 ( click the link to review the publication )

J Biol Chem,2020,27;jbc.RA120.012981.

PubMed: 32461254 ( click the link to review the publication )

Breast Cancer Res Treat,2020,179(2):337-347.

PubMed: 31655920 ( click the link to review the publication )

PLoS One,2020,15(1):e0228189

PubMed: 31999754 ( click the link to review the publication )

J Allergy Clin Immunol,2020,21;S0091-6749(20)30259-1.

PubMed: 32088305 ( click the link to review the publication )

bioRxiv,2020,doi:10.1101/2020.05.26.117770

PubMed: No ( click the link to review the publication )

blood,2019,10.1182/blood-2019-130910

PubMed: no ( click the link to review the publication )

Genome Biol,2019,20(1):253

PubMed: 31771620 ( click the link to review the publication )

Sci Adv,2019,5(6):eaav9784

PubMed: 31249867 ( click the link to review the publication )

Cell Rep,2019,5;26(6):1544-1556.e8.

PubMed: 30726737 ( click the link to review the publication )
Neuropsychopharmacology,2019,10.1038/s41386-018-0266-7

PubMed: 30518933 ( click the link to review the publication )

Cancers (Basel),2019,30;11(2):156.

PubMed: 30704052 ( click the link to review the publication )

Breast Cancer Res,2019,21(1):37

PubMed: 30845991 ( click the link to review the publication )

Cell Chem Biol,2019,21;26(2):235-243.e5.

PubMed: 30527999 ( click the link to review the publication )

Neurobiol Aging,2019,76:24-34

PubMed: 30640040 ( click the link to review the publication )

Cancer Gene Ther,2019,10.1038/s41417-019-0127-5

PubMed: 31383953 ( click the link to review the publication )

Stem Cells Int,2019,2019:3435901

PubMed: 31871467 ( click the link to review the publication )

Cancer Manag Res,2019,11:8391-8405

PubMed: 31571995 ( click the link to review the publication )

Breast Cancer Res Treat,2019,10.1007/s10549-019-05504-5

PubMed: 31784862 ( click the link to review the publication )

Acta Pharmacol Sin,2019,10.1038/s41401-019-0246-4

PubMed: 31197246 ( click the link to review the publication )

Cell Signal,2019,67:109508

PubMed: 31866490 ( click the link to review the publication )

Virology,2019,541:41-51

PubMed: 31826845 ( click the link to review the publication )

Int J Parasitol Drugs Drug Resist,2019,10:28-37.

PubMed: 31015150 ( click the link to review the publication )

J Med Virol,2019,91(8):1440-1447.

PubMed: 30900754 ( click the link to review the publication )

Bioengineered,2019,10(1):98-107

PubMed: 31023186 ( click the link to review the publication )

Kaohsiung J Med Sci,2019,10.1002/kjm2.12051

PubMed: 30896891 ( click the link to review the publication )

Nat Commun,2018,9(1):1655

PubMed: 29695808 ( click the link to review the publication )

Cell Rep,2018,22(5):1185-1199

PubMed: 29386107 ( click the link to review the publication )

EBioMedicine,2018,28:80-89.

PubMed: 29396295 ( click the link to review the publication )

Cancer Sci,2018,109(4):1220-1229

PubMed: 29453896 ( click the link to review the publication )

Sci Rep,2018,8(1):13106

PubMed: 30166612 ( click the link to review the publication )

Sci Rep,2018,21;8(1):14178.

PubMed: 30242186 ( click the link to review the publication )

J Cell Physiol,2018,233(1):422-433

PubMed: 28294327 ( click the link to review the publication )

Oncotarget,2018,9(57):31018-31031

PubMed: 30123424 ( click the link to review the publication )
Methods Mol Biol,2018,1795:203-221.

PubMed: 29846930 ( click the link to review the publication )

Nat Commun,2017,17;8:16078.

PubMed: 28714472 ( click the link to review the publication )

Lab Chip,2017,31;17(3):511-520.

PubMed: 28092382 ( click the link to review the publication )

Anal Chem,2017,89(12):6678-6685

PubMed: 28520400 ( click the link to review the publication )

Antimicrob Agents Chemother,2017,62(1)

PubMed: 29061736 ( click the link to review the publication )

PLoS One,2017,5;12(1):e0169407.

PubMed: 28056055 ( click the link to review the publication )

Parasitol Res,2017,116(10):2619-2626.

PubMed: 28776226 ( click the link to review the publication )

Biol Pharm Bull,2017,40(8):1289-1298.

PubMed: 28769010 ( click the link to review the publication )

Pharmacol Res,2016,113(Pt A):216-227

PubMed: 27543462 ( click the link to review the publication )

Biogerontology,2016,17(5-6):907-920.

PubMed: 27484416 ( click the link to review the publication )

PLoS One,2016,11(2):e0149848

PubMed: 26919709 ( click the link to review the publication )

Sensors (Basel),2016,16(3)

PubMed: 26999137 ( click the link to review the publication )

Database (Oxford),2016,7;2016:baw041.

PubMed: 27055828 ( click the link to review the publication )

Genome Biol,2015,19;16(1):127.

PubMed: 26084335 ( click the link to review the publication )

Clin Cancer Res,2015,21(5):1172-82

PubMed: 25549722 ( click the link to review the publication )

Biosens Bioelectron,2015,68:699-704

PubMed: 25668591 ( click the link to review the publication )

Cancer Discov,2015,5(2):154-67.

PubMed: 25501949 ( click the link to review the publication )

Mol Cancer Ther,2015,14(5):1213-23

PubMed: 25777964 ( click the link to review the publication )

Cell Cycle,2015,14(1):109-22

PubMed: 25602521 ( click the link to review the publication )

PLoS One,2015,10(11):e0142655

PubMed: 26569102 ( click the link to review the publication )

Oncotarget,2015,6(3):1531-43

PubMed: 25605238 ( click the link to review the publication )

Head Neck,2015,37(12):1722-32

PubMed: 24986420 ( click the link to review the publication )

Mol Cancer Res,2014,12(5):703-13

PubMed: 24554781 ( click the link to review the publication )

Oncotarget,2014,5(15):6512-25

PubMed: 25156567 ( click the link to review the publication )
Curr Protoc Chem Biol,2014,4:177-191

PubMed: 26705509 ( click the link to review the publication )

Selleck化合物ライブラリー使用例

肝癌研究におけるGPCR Compound Libraryの使用例（当文献はNature (IF=43)に掲載され、研究期間は約15ヶ月です）：
Nature.2019;574(7777):268-272
大腸癌研究におけるKinase Inhibitor Library の使用例（当文献はNature Communications (IF=11)に掲載され、研究期間は約8ヶ月です）：
Nat Commun. 2019 16;10(1):2197
抗ウイルス研究におけるFDA-approved Drug Libraryの使用例（当文献はCell Research (IF=17)に掲載され、研究期間は約13ヶ月です）：
Cell Res. 2019;29(9):739-753
代謝研究におけるFDA-approved Drug Library使用例（当文献はMovement Disorders (IF=8)に掲載され、研究期間は約10ヶ月です）：
Mov Disord. 2019;34(3):323-334
白血病研究におけるEpigenetics Compound Libraryの使用例（当文献は Blood (IF=16)に掲載され、研究期間は約16ヶ月です）：
Blood. 2019 17;134(16):1323-1336
癌免疫研究におけるInhibitor Libraryの使用例（当文献はCancer Immunol Res (IF=8.6)に掲載され、研究期間は約12ヶ月です）：
Cancer Immunol Res.2017;5(9):790-803

製品特性＆メリット

・世界中で販売されている薬剤と、第1相臨床試験を通過した2879種類の薬剤ライブラリー。HTS（High Throughput Screening）およびHCS（High Content Screening）に使用できます。

・既存の薬剤を用いて新たな適応症への効果を模索します。新薬開発よりも低コストで迅速な臨床効果が期待できます。

・第1相臨床試験で安全性が確認されました。

・腫瘍、心臓病、抗炎症、免疫、神経精神病、鎮痛などに関連しています。

・構造的に多様で、薬効および細胞透過性が確認されています。

・構造、IC50、お客様からのレビューなど豊富な情報があります

・NMRとHPLC検査で製品の高純度を保証しています。

製品詳細情報

調合：	2549 compounds pre-dissolved in 10mM DMSO, 230 compounds pre-dissolved in 10mM water, 83 compounds pre-dissolved in 2mM DMSO and 17 compounds pre-dissolved in 2mM water
ケース：	96/384 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
安定性：	12 months -20°Cin DMSO
安定性：	24 months -80°Cin DMSO
出荷方式：	ブルーアイス物流
包装：	不活性ガス（Inert gas）

FDA-approved & Passed Phase I Drug Library组成

HTS パートナ

他のライブラリー

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A unique collection of 2655 FDA approved drugs for high throughput screening (HTS) and high content screening (HCS).
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Kinase Inhibitor Library

A unique collection of 1525 kinase inhibitors for high throughput screening (HTS) and high content screening (HCS).
Express-Pick Library

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Alkaloid Compound Library

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Angiogenesis Related compound Library

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Anti-Aging Compound Library

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Anti-alzheimer Disease Compound Library

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Antibiotics compound Library

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Anti-cancer Compound Library

A unique collection of 3403 anti-cancer small molecules for 12 types of cancers: Breast Cancer, Leukemia, Lung Cancer, Lymphoma, etc.
Anti-cancer Compound Library (Verified by Broad Institute)

A unique collection of 881 compounds with anticancer activity which has been verified by broad institute,half of the compounds are non-oncology drugs.
Anti-cancer Metabolism Compound Library

A unique collection of 185 small molecules for cancer metabolism research.
Anti-Cardiovascular Disease Compound Library

A unique collection of 683 anti-cardiovascular disease related compounds used for high throughput screening(HTS) and high content screening(HCS).
Anti-diabetic Compound Library

A unique collection of 138 small molecules affecting the development of diabetes.
Anti-infection Compound Library

A unique collection of 900 anti-infective small molecules with biological activity of antibiotics,antifungal drugs,anti-HIV,etc.
Antioxidant Compound Library

A unique collection of 421 compounds used for exploring the relationship between anti-oxidation and some diseases such as aging,cancer,alzheimer's disease,parkinson's disease,diabetes,etc.
Anti-parasitic Compound Library

A unique collection of 162 anti-parasitic compounds used for high throughput screening(HTS) and high content screening(HCS).
Antiviral Compound Library

A unique collection of 335 antiviral compounds used for exploring novel antiviral drug.
Apoptosis Compound Library

A unique collection of 1052 small molecules used for apoptosis research targeting Bcl-2,Caspase,p53,TNF-alpha,Mdm2,survivin, etc.
Autophagy Compound Library

A unique collection of 956 small molecules with autophagy-inducing or autophagy-inhibiting activity.
Cambridge Cancer Compound Library

A unique collection of 230 anti-cancer compounds for high throughput screening (HTS) and high content screening (HCS).
Cell Cycle compound library

A unique collection of 115 small molecule compounds used for cell cycle and related diseases research
CNS-Penetrant Compound Library

A unique collection of 302 CNS-Penetrant compounds with biological activity for neurologic research.
Covalent Inhibitor Library

A unique collection of 74 covalent Inhibitors for high throughput screening (HTS) and high content screening (HCS).
Cytoskeletal Signaling Pathway Compound Library

A unique collection of 179 compounds used for research in cytoskeleton and cytoskeletal interactions.
DNA Damage/DNA Repair compound Library

A unique collection of 493 small molecules used for DNA Damage and Repair research targeting PARP,ATM/ATR,Topoisomerase,DNA/RNA Synthesis etc.
Drug-like Compound Library

A unique collection of 2000 drug-like compounds used for high throughput screening(HTS) and high content screening(HCS).
Endoplasmic Reticulum Stress Compound Library

A unique collection of 89 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening(HTS) and high content screening(HCS).
Epigenetics Compound Library

Selleck Epigenetic inhibitor Library contains various small molecule modulators (inhibitors and activators) with biological activity used for epigenetic research and associated assays.
FDA-approved Anticancer Drug Library

A unique collection of 1518 approved drugs with anticancer activity used for high throughput screening(HTS) and high content screening(HCS).
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A unique collection of 534 compounds used for exploring the mechanism of ferroptosis which is an iron-dependent form of non-apoptotic cell death.
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A unique collection of 184 flavonoid compounds used for high throughput screening(HTS) and high content screening(HCS).
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A unique collection of 939 Fragment compounds for Fragment-Based Drug Discovery (FBDD).
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A unique collection of 228 glutamine metabolism related compounds used for high throughput screening (HTS) and high content screening (HCS).
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A unique collection of 86 gut microbial metabolites used for high throughput screening(HTS) and high content screening(HCS).
HIF-1 Signaling Pathway Compound Library

A unique collection of 425 HIF-1 signaling pathway compounds used for oxygen sensing related research.
Highly Selective Inhibitor Library

A unique collection of 312 validated bioactive compounds covering over 119 targets.
Histone modification compound library

A unique collection of 190 compounds with biological activity used for histone modification research and associated assays
HTS Library for Drug Discovery

A unique collection of 99040 compounds features numerous structurally diverse compounds and several alternate compositions.
Immunology/Inflammation Compound Library

A unique collection of 1779 small molecules modulators (inhibitors and activators) with biological activity used for Immunology/Inflammation research and associated assays.
Inhibitor Library

A unique collection of 3291 inhibitors for high throughput screening (HTS) and high content screening (HCS).
Ion Channel Ligand Library

A unique collection of 226 small molecule modulators used for Ion channel research.
JAK/STAT compound library

A unique collection of 39 small molecules used for research in JAK-STAT signaling pathway.
Macrocyclic Compound Library

A unique collection of 104 macrocyclic compounds used for high throughput screening(HTS) and high content screening(HCS).
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A unique collection of 166 small molecule inhibitors used for MAPK signaling research.
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A unique collection of 129 nucleoside analogues used for high throughput screening(HTS) and high content screening(HCS).
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研究分野別

製品類型