Antifolate

Antifolate製品

All (18)
Antifolate阻害剤 (14)
Antifolate抗体(1)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S1210	Methotrexate	Methotrexate, analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis.	J Clin Invest, 2025, e190215 Theranostics, 2025, 15(10):4526-4549 Antimicrob Agents Chemother, 2025, e0047125.
S1135	Pemetrexed disodium	Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with K_i of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.	Nat Commun, 2025, 16(1):8932 Cell Death Dis, 2024, 15(8):555 Cell Commun Signal, 2024, 22(1):375
S7785	Pemetrexed Disodium Hydrate	Pemetrexed Disodium Hydrate (LY-231514) is a novel antifolate and antimetabolite for TS, DHFR and GARFT with K_i of 1.3 nM, 7.2 nM and 65 nM, respectively. Pemetrexed Disodium Hydrate stimulates autophagy and apoptosis.	iScience, 2024, 27(10):110862 Cell Rep, 2022, 38(9):110448 Front Pharmacol, 2022, 13:1032975
S5971	Pemetrexed	Pemetrexed (LY231514) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.	Nat Commun, 2025, 16(1):7853 Nat Commun, 2025, 16(1):8476 Sci Adv, 2025, 11(4):eadp4765
S5097	Methotrexate disodium	Methotrexate disodium, an analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis.	Chin Med J (Engl), 2023, 10.1097/CM9.0000000000002816 Pharmaceutics, 2023, 15(2)576 Pharmaceutics, 2023, 15(2)576
S1497	Pralatrexate	Pralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines. Pralatrexate induces tumor cell apoptosis.	Cell Rep Med, 2025, S2666-3791(25)00102-8 Br J Haematol, 2024, 10.1111/bjh.19658 Discov Oncol, 2024, 15(1):709
S2006	Pyrimethamine	Pyrimethamine(RP 4753) is a dihydrofolate reductase (DHFR) inhibitor, used as an antimalarial drug.	Antimicrob Agents Chemother, 2025, e0047125. Int J Parasitol Drugs Drug Resist, 2025, 29:100626 BMC Cancer, 2024, 24(1):116
S1236	Leucovorin (Folinic acid) Calcium Pentahydrate	Leucovorin (Folinic acid) Calcium Pentahydrate is a derivative of folic acid, which can be used to increase levels of folic acid under conditions favoring folic acid inhibition.Solutions are unstable and should be fresh-prepared.	J Exp Clin Cancer Res, 2025, 44(1):13 iScience, 2024, 27(10):110862 Cell Rep Med, 2023, 4(10):101200
S2588	Calcium Folinate	Calcium Folinate is a calcium salt of folinic acid that is an adjuvant used in cancer chemotherapy.Solutions are unstable and should be fresh-prepared.	Drug Resist Updat, 2023, 71:101005
S5790	Folinic acid (Leucovorin)	Folinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS).Solutions are unstable and should be fresh-prepared.	Nat Cell Biol, 2024, Nat Commun, 2022, 13(1):6308
S3129	Trimethoprim	Trimethoprim (BW 56-72, NIH 204, NSC-106568) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections.	Cell Rep, 2024, 43(7):114500 Sci Rep, 2024, 14(1):9167 Sci Rep, 2024, 14(1):9167
S5264	L-5-Methyltetrahydrofolate calcium	Calcium L-5-methyltetrahydrofolate (L-5-MTHF-Ca) is a synthetic derivative of folic acid, the predominant, naturally occurring form of folate.
E4837	Trimethoprim (lactate)	Trimethoprim (lactate) is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), an essential enzyme responsible for the production of tetrahydrofolic acid (THF). By blocking this enzyme, trimethoprim prevents the synthesis of bacterial DNA, hindering bacterial survival. It is a standard antibiotic for treating urinary tract infections (UTIs).
S3082	Proguanil HCl(Atovaquone)	Proguanil hydrochloride(Chloroguanil, Chlorguanide hydrochloride), an antimalarial proagent acts as an inhibitor of dihydrofolate reductase (DHFR). Proguanil acts as a biguanide to enhance the Atovaquone effect.
A2491	Mirvetuximab (Anti-FOLR1)	Mirvetuximab (Anti-FOLR1) is a monoclonal antibody targeting FOLR1 (folate receptor 1). Mirvetuximab is the antibody moiety of novel folate receptor alpha (FRα)-targeting ADC (Mirvetuximab soravtansine). MW: 145.2 KD
A2492	Farletuzumab (Anti-FOLR1)	Farletuzumab (Anti-FOLR1) is a humanized monoclonal antibody with high affinity for FRα. It is a potent folate receptor-alpha (FRα) inhibitor. Farletuzumab possesses growth-inhibitory functions on cells overexpressing FRα. Farletuzumab can be used in research of cancer. MW: 144.12 KD
E1003	Aminopterin	Aminopterin (4-amino Folic Acid, 4-amino PGA, 4-Aminofolic acid, 4-Aminopteroylglutamic acid, Aminopteroylglutamic acid, APGA, NSC 739), a folic acid antagonist, is a competitive inhibitor of dihydrofolate reductase (DHFR) with Ki of 3.7 pM.	Mol Cancer Res, 2024, 22(1):82-93
S5200	Diaveridine	Diaveridine (AI3-23935, CCRIS-3784) is coccidiostat with anti-parasitic activity and also a dihydrofolate reductase (DHFR) inhibitor preventing folic acid synthesis in species of Pneumocystis.
A2492	Farletuzumab (Anti-FOLR1)	Farletuzumab (Anti-FOLR1) is a humanized monoclonal antibody with high affinity for FRα. It is a potent folate receptor-alpha (FRα) inhibitor. Farletuzumab possesses growth-inhibitory functions on cells overexpressing FRα. Farletuzumab can be used in research of cancer. MW: 144.12 KD
S1210	Methotrexate	Methotrexate, analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis.	J Clin Invest, 2025, e190215 Theranostics, 2025, 15(10):4526-4549 Antimicrob Agents Chemother, 2025, e0047125.
S1135	Pemetrexed disodium	Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with K_i of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.	Nat Commun, 2025, 16(1):8932 Cell Death Dis, 2024, 15(8):555 Cell Commun Signal, 2024, 22(1):375
S7785	Pemetrexed Disodium Hydrate	Pemetrexed Disodium Hydrate (LY-231514) is a novel antifolate and antimetabolite for TS, DHFR and GARFT with K_i of 1.3 nM, 7.2 nM and 65 nM, respectively. Pemetrexed Disodium Hydrate stimulates autophagy and apoptosis.	iScience, 2024, 27(10):110862 Cell Rep, 2022, 38(9):110448 Front Pharmacol, 2022, 13:1032975
S5971	Pemetrexed	Pemetrexed (LY231514) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.	Nat Commun, 2025, 16(1):7853 Nat Commun, 2025, 16(1):8476 Sci Adv, 2025, 11(4):eadp4765
S5097	Methotrexate disodium	Methotrexate disodium, an analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis.	Chin Med J (Engl), 2023, 10.1097/CM9.0000000000002816 Pharmaceutics, 2023, 15(2)576 Pharmaceutics, 2023, 15(2)576
S1497	Pralatrexate	Pralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines. Pralatrexate induces tumor cell apoptosis.	Cell Rep Med, 2025, S2666-3791(25)00102-8 Br J Haematol, 2024, 10.1111/bjh.19658 Discov Oncol, 2024, 15(1):709
S2006	Pyrimethamine	Pyrimethamine(RP 4753) is a dihydrofolate reductase (DHFR) inhibitor, used as an antimalarial drug.	Antimicrob Agents Chemother, 2025, e0047125. Int J Parasitol Drugs Drug Resist, 2025, 29:100626 BMC Cancer, 2024, 24(1):116
S2588	Calcium Folinate	Calcium Folinate is a calcium salt of folinic acid that is an adjuvant used in cancer chemotherapy.Solutions are unstable and should be fresh-prepared.	Drug Resist Updat, 2023, 71:101005
S5790	Folinic acid (Leucovorin)	Folinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS).Solutions are unstable and should be fresh-prepared.	Nat Cell Biol, 2024, Nat Commun, 2022, 13(1):6308
E4837	Trimethoprim (lactate)	Trimethoprim (lactate) is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), an essential enzyme responsible for the production of tetrahydrofolic acid (THF). By blocking this enzyme, trimethoprim prevents the synthesis of bacterial DNA, hindering bacterial survival. It is a standard antibiotic for treating urinary tract infections (UTIs).
S3082	Proguanil HCl(Atovaquone)	Proguanil hydrochloride(Chloroguanil, Chlorguanide hydrochloride), an antimalarial proagent acts as an inhibitor of dihydrofolate reductase (DHFR). Proguanil acts as a biguanide to enhance the Atovaquone effect.
E1003	Aminopterin	Aminopterin (4-amino Folic Acid, 4-amino PGA, 4-Aminofolic acid, 4-Aminopteroylglutamic acid, Aminopteroylglutamic acid, APGA, NSC 739), a folic acid antagonist, is a competitive inhibitor of dihydrofolate reductase (DHFR) with Ki of 3.7 pM.	Mol Cancer Res, 2024, 22(1):82-93
S5200	Diaveridine	Diaveridine (AI3-23935, CCRIS-3784) is coccidiostat with anti-parasitic activity and also a dihydrofolate reductase (DHFR) inhibitor preventing folic acid synthesis in species of Pneumocystis.
A2491	Mirvetuximab (Anti-FOLR1)	Mirvetuximab (Anti-FOLR1) is a monoclonal antibody targeting FOLR1 (folate receptor 1). Mirvetuximab is the antibody moiety of novel folate receptor alpha (FRα)-targeting ADC (Mirvetuximab soravtansine). MW: 145.2 KD