Favipiravir (T-705)

For research use only. Not for use in humans.

製品コードS7975

Favipiravir (T-705)化学構造

CAS No. 259793-96-9

Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections.

サイズ 価格(税別)  
JPY 19700
JPY 67900
JPY 167500
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バルク問合せ

カスタマーフィードバック(2)

  • (A) BoDV-1 infection was measured by IFA. BoDV-1 P40 was detected with a primary monoclonal antibody (red), nuclei were stained with DAPI (blue), merged image (scale bars: 50 μm). Favipiravir: T-705

    Cell Physiol Biochem, 2018, 49(1):381-394. Favipiravir (T-705) purchased from Selleck.

  • (B) IFA of Vero-rBoDV-1-Gluc cells treated with T-705. Vero-rBoDV-1-Gluc cells were treated as indicated and the cells were stained with an anti-P antibody (shown in green) and DAPI (shown in blue). Bars, 50 μm.

    Antiviral Res, 2017, 143:237-245. Favipiravir (T-705) purchased from Selleck.

製品安全説明書

DNA/RNA Synthesis阻害剤の選択性比較

生物活性

製品説明 Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections.
ターゲット
RNA-dependent RNA polymerase [1]
体外試験

Favipiravir shows anti-influenza virus activities with IC50 ranged from 0.013 to 0.48 μg/ml for the influenza A viruses, from 0.039 to 0.089 μg/ml for the influenza B viruses, and from 0.030 to 0.057 μg/ml for the influenza C viruses. In mammalian cell lines (MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells), Favipiravir shows no cytotoxicity at concentrations up to 1,000 μg/ml. [1] In MDCK cells inoculated with seasonal influenza A (H1N1) viruses, Favipiravir induces lethal mutagenesis. [2]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDCK NUfp[mk2SW62aY\pdoFtKGG|c3H5 MUWzJIRigXN? NVXmSJdUSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WSjbXHueIFv\S2{ZYPpd5RidnRienHuZY1qfmm{LTzvd4VtfGGvaY\pdk1{fXOlZYD0bYJt\SCLbn\seYVvgmFiQTD2bZJ2eyBqQT;O[ZchYW:{az:zOE8zODB6KFixUlEqMSCqYYLic5JqdmdiTUKgUFI3USCvdYThcpQhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wIHHmeIVzKDNiZHH5d{BjgSCvaXPyc5Nkd3CrYzDhcoFtgXOrLDDFR|UxKD1iMD6xPUDPxE1w NVvOVXFXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
MDCK MXnBcpRqfmm{YXygZZN{[Xl? MlL5N{Bl[Xm| MWjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDh[IFu[W62YX7lMUwhd3OnbIThcYl3cXJvLDD6ZY5idWm4aYKtd5V{[2WydHnicIUhUW6obIXlcppiKEFidnnyeZMhMEFxQX7uJGFz[m:{L{[vNVk3OCiKMl6yLUkhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wIHHmeIVzKDNiZHH5d{BjgSCvaXPyc5Nkd3CrYzDhcoFtgXOrczD1d4lv\yClconzeIFtKH[rb3zleEB{fGGrbjygSWM2OCB;IECuN|gh|ryPLh?= M1ywTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{WwPVQ6Lz5{MEO1NFk1QTxxYU6=
MDCK MUnBcpRqfmm{YXygZZN{[Xl? NFPJWWY{KGSjeYO= MlHsRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYRidWGwdHHu[U1z\XOrc4ThcpQhgmGwYX3peolzNSyxc3XseIFucX[rcj3zeZNk\XC2aXLs[UBKdm[udXXufoEhSSC4aYL1d{ApSS:IbH;ybYRiNzBzL{KwNFkpUDOQMjmpJIhiemKxcnnu[{BOOiCVM{HOJI12fGGwdDDpcoZm[3SnZDDpckBOTEONIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXygdoVxdGmlYYTpc44h[W[2ZYKgN{Bl[Xm|IHL5JI1q[3Kxc3PvdIlkKGGwYXz5d4l{NCCHQ{WwJF0hOC52NTFOwG0v MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN3MEm0PUc,OjB|NUC5OFk9N2F-
MDCK NEfSVVdCdnSrdnnyZYwh[XO|YYm= MVWzJIRigXN? MUPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDvd4VtfGGvaY\pdk1{fXOlZYD0bYJt\SC8YX7hcYl3cXJvLDDh[IFu[W62YX7lMZJme2m|dHHueEBKdm[udXXufoEhSiC4aYL1d{BDN02nbYDobZMwOjBxMUm5OkBp[XKkb4LpcochdmW3cnHtbY5q\GG|ZTDSNVUzUyCvdYThcpQhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wIHHmeIVzKDNiZHH5d{BjgSCvaXPyc5Nkd3CrYzDhcoEtKEWFNUCgQUAxNjV5IN88UU4> NH;2fYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO1NFk1QSd-MkCzOVA6PDl:L3G+
MDCK NI\6TVhCdnSrdnnyZYwh[XO|YYm= MW[zJIRigXN? NETEVZVCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBi\GGvYX70ZY5mNSxib4PlcJRidWm4aYKtMEB7[W6jbXn2bZIue3W|Y3XweIljdGViSX7mcJVmdnqjIFGgeolzfXNiKFGvV5dqdmVxU3;1eIghTGGtb4ThM|A{NzJyMEioTFFPOSlrIHnu[oVkfGWmIHnuJG1FS0tiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXKjbDDy[ZBtcWOjdHnvckBi\nSncjCzJIRigXNiYomgcYlkem:|Y3;wbYMh[W6jbInzbZMhfXOrbnegZ5J6e3SjbDD2bY9t\XRuIFXDOVAhRSByLkizJO69VS5? M4jlfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{WwPVQ6Lz5{MEO1NFk1QTxxYU6=
MDCK M13DXmFvfGm4aYLhcEBie3OjeR?= M3n1VFMh\GG7cx?= M{PNbWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl[W2jboThcoUue3W|Y3XweIljdGVienHuZY1qfmm{LTygc5NmdHSjbXn2bZIuemW|aYP0ZY51KEmwZnz1[Y57[SCDII\pdpV{KCiDL1LyZZpqdC9zNkOzM|IxODhqSEHONUkqKGijcnLvdolv\yCwZYXyZY1qdmmmYYPlJHEyOz[NIH31eIFvfCCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiMzDkZZl{KGK7IH3pZ5JweyxiRVO1NEA:KDBwOEOg{txONg>? M4HkcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{WwPVQ6Lz5{MEO1NFk1QTxxYU6=
MDCK Mn\yRY51cX[rcnHsJIF{e2G7 M{P2UVMh\GG7cx?= NXPxd|dOSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WSjbXHueIFv\S2{ZYPpd5RidnRienHuZY1qfmm{LTzvd4VtfGGvaY\pdk1{fXOlZYD0bYJt\SCLbn\seYVvgmFiQTD2bZJ2eyBqQT;w[I0wS2GuaX\vdo5q[S9yNT:yNFA6KCiKMV6xLUkhcGG{Yn;ybY5oKE1{IG[yPGktKFN|MV6gcZV1[W62IHnu[oVkfGWmIHnuJG1FS0tiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXKjbDDy[ZBtcWOjdHnvckBi\nSncjCzJIRigXNiYomgcYlkem:|LDDFR|UxKD1iMD64N{DPxE1w NULVVYpGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
MDCK M2m3RmFvfGm4aYLhcEBie3OjeR?= MYWzJIRigXN? NY\sPWltSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WSjbXHueIFv\S2{ZYPpd5RidnRienHuZY1qfmm{LTzvd4VtfGGvaY\pdk1{fXOlZYD0bYJt\SCLbn\seYVvgmFiQTD2bZJ2eyBqQT;w[I0wVmW5IGnvdoswOThxMkCwPUApUDGQMTmpJIhiemKxcnnu[{BOOiCYMkjJMEBUOzGQIH31eIFvfCCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiMzDkZZl{KGK7IH3pZ5Jwe2OxLDDFR|UxKD1iMD64PUDPxE1w M3[1b|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{WwPVQ6Lz5{MEO1NFk1QTxxYU6=
MDCK NGr1ToVCdnSrdnnyZYwh[XO|YYm= Mn[4N{Bl[Xm| NWH5UJNISW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WSjbXHueIFv\S1uIIrhcoFucX[rcj3zeZNk\XC2aXLs[UBwe2WudHHtbZZqei2{ZYPpd5RidnRiSX7mcJVmdnqjIFGgeolzfXNiKFGveJVzc2W7L13pco5me2:2YT:4N|MwOTl6MDjIOG4zMSliaHHyZo9zcW6pIH7leZJidWmwaXThd4UhTTFzOVegcZV1[W62IHnu[oVkfGWmIHnuJG1FS0tiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXKjbDDy[ZBtcWOjdHnvckBi\nSncjCzJIRigXNiLDDFR|UxKD1iMD64PUDPxE1w Mmn1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|NUC5OFkoRjJyM{WwPVQ6RC:jPh?=
MDCK MoPRRY51cX[rcnHsJIF{e2G7 M3vzNlMh\GG7cx?= M2nhPWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl[W2jboThcoUuNCCxc3XseIFucX[rcj2sJJpidmGvaY\pdk1{fXOlZYD0bYJt\SCLbn\seYVvgmFiQTD2bZJ2eyBqQT;0eZJs\XlxTXnucoV{d3SjL{izN{8yQThyKFi0UlIqMSCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiMzDkZZl{KGK7IH3pZ5Jwe2OxcHnjJIFv[Wy7c3nzJJV{cW6pIHPyfZN1[WxidnnvcIV1KCxiRVO1NEA:KDBwOU[g{txONg>? MlPFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|NUC5OFkoRjJyM{WwPVQ6RC:jPh?=
MDCK NELpb|VCdnSrdnnyZYwh[XO|YYm= MYXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDvd4VtfGGvaY\pdk1{fXOlZYD0bYJt\SC8YX7hcYl3cXJvLDDh[IFu[W62YX7lMZJme2m|dHHueEBKdm[udXXufoEhSSC4aYL1d{ApSS:EZYTo[ZNl[S97NU[vNlAxPiiKM16yLUkhcGG{Yn;ybY5oKG6ndYLhcYlvcWSjc3WgVlI6OktibYX0ZY51KGGwZDDNNkBUOzGQIH31eIFvfCCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYYtKEWFNUCgQUAyNjJzIN88UU4> NVn5TnA4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
MDCK NYPRWnQ2SW62aY\pdoFtKGG|c3H5 NV3v[VNTOyCmYYnz MV3BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDh[IFu[W62YX7lMZJme2m|dHHueEB7[W6jbXn2bZIuNG:|ZXz0ZY1qfmm{LYP1d4NmeHSrYnzlJGlv\my3ZX76ZUBCKH[rcoXzJEhCN3CmbT;N[Zhq[29xNE[wOE8zODB7IDjINW4yMSliaHHyZo9zcW6pIF2yJHYzQEluIGOzNW4hdXW2YX70JIlv\mWldHXkJIlvKE2GQ1ugZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBz\XCuaXPheIlwdiCjZoTldkA{KGSjeYOgZpkhdWmlcn;zZ48tKEWFNUCgQUAyNjJzIN88UU4> NVHGRolKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
MDCK MYXBcpRqfmm{YXygZZN{[Xl? NHXGNIk{KGSjeYO= M2PVV2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl[W2jboThcoUuemW|aYP0ZY51KHqjbnHtbZZqei1ub4PlcJRidWm4aYKtd5V{[2WydHnicIUhUW6obIXlcppiKEJidnnyeZMhSi:PZX3wbIl{NzJyL{G5PVYhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wIHHmeIVzKDNiZHH5d{BjgSCvaXPyc5Nkd3CrYzDhcoFtgXOrczD1d4lv\yClconzeIFtKH[rb3zleEB{fGGrbjygSWM2OCB;IEGuNlEh|ryPLh?= MoHJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|NUC5OFkoRjJyM{WwPVQ6RC:jPh?=
MDCK M4niSGFvfGm4aYLhcEBie3OjeR?= M{nG[GFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl[W2jboThcoUuNCCxc3XseIFucX[rcj2sJJpidmGvaY\pdk1{fXOlZYD0bYJt\SCLbn\seYVvgmFiQTD2bZJ2eyBqQT;jbIlkc2WwL2\p[ZRv[W1xTlPWSFExOy9{MEC3JINt[WSnIEKuN{41KCiKNV6xLUkhcGG{Yn;ybY5oKG6ndYLhcYlvcWSjc3WgTVIzOlRibYX0ZY51KGmwZnXjeIVlKGmwIF3ER2sh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCC{ZYDsbYNifGmxbjDh[pRmeixiRVO1NEA:KDFwMkeg{txONg>? NYKyOIhURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
MDCK NWmxfY04SW62aY\pdoFtKGG|c3H5 M3P3eGlvcGmkaYTpc44hd2ZidnnyZYwhemWybHnjZZRqd25ib3[gbY5ndHWnborhJGEhfmm{dYOgLGEwUG:wZzDLc45oNzJzMz:wN{hJPU5zKTmgZY5lKGmwZnz1[Y57[SCDII\pdpV{KCiDL1HuckBCemKxcj:2M|YxMEh{TkKpLUBpgWK{aXSgeolzfXNiaX6gUWREUyClZXzsd{BjgSC4aYL1d{B6cWWuZDDy[YR2[3Srb36gZZN{[XluIFXDPVAhRSBzLkOg{txONg>? MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF7NEizNkc,OTdzOUS4N|I9N2F-
MDCK MYHBcpRqfmm{YXygZZN{[Xl? MYqxJIhz NXLpU|IxSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUW6obIXlcppiKEJidnnyeZMhMEJxQoLpd4JidmVxNkCvNlAxQCliaX7m[YN1\WRiaX6gUWREUyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHliYYSgNUBpeiCyb4P0MYlv\mWldHnvckBu\WG|dYLl[EBi\nSncjCzJIRigXNiYomg[ox2d3Knc3PlbY4u\GmjY3X0ZZRmKGKjc3XkJIZtfW:{aX3leJJq[yCjbnHsfZNqeyxiRVO1NEA:KDFwM{Kg{txONg>? MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzRzOUezPEc,OjN2MUm3N|g9N2F-
MDCK Mk\XRY51cX[rcnHsJIF{e2G7 Mn:1RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYRidWGwdHHu[U0tKG:|ZXz0ZY1qfmm{LTygfoFv[W2rdnnyMZJme2m|dHHueEBKdm[udXXufoEhSSC4aYL1d{ApSS:YaXX0coFuN0iQM{C0NFgwOjByNTDONlk1WyClbHHk[UAyKCiKNV6xLUkhcGG{Yn;ybY5oKE1{IFyyOmktKFN|MV6gcZV1[W62IHHu[EBv\XW{YX3pcoll[XOnIF6yPVRUKG23dHHueEBqdm[nY4Tl[EBqdiCPRFPLJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhNCCHQ{WwJF0hOS5|NEGg{txONg>? M1q3WVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{WwPVQ6Lz5{MEO1NFk1QTxxYU6=
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MDCK MXrBcpRqfmm{YXygZZN{[Xl? MmrkRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgNE4xODFiTV;JJIFl[W2jboThcoUuemW|aYP0ZY51KHqjbnHtbZZqei1ub4PlcJRidWm4aYKtd5V{[2WydHnicIUhUW6obIXlcppiKEFidnnyeZMhMEFxcHTtM21mgGmlbz:0OlA1NzJyMEmoTFFPOSlrIHjhdoJwemmwZzDNNkBXOjiLLDDTN|FPKG23dHHueEBqdm[nY4Tl[EBqdiCPRFPLJINmdGy|IHHzd4V{e2WmIHHzJIRmfGW{bXnuZZRqd25ib3[geolz[WxidHn0[ZIhcW5iY3XscEBkfWy2dYLlJIF1NCCQVVzMJF0hVlWOTDFOwG0v M3PaOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{WwPVQ6Lz5{MEO1NFk1QTxxYU6=
MDCK NETmZVRCdnSrdnnyZYwh[XO|YYm= MUfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDCwMlAxOSCPT1mgZYRidWGwdHHu[U1z\XOrc4ThcpQhgmGwYX3peolzNSyxc3XseIFucX[rcj3zeZNk\XC2aXLs[UBKdm[udXXufoEhSSC4aYL1d{ApSS:yZH2vR4FtcW[xcn7pZU8xPC9{MEC5LGgyVjFrKTDoZZJjd3KrbnegUVIhXjJ6STygV|MyViCvdYThcpQhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{Bl\XSncn3pcoF1cW:wIH;mJJZqemGuIITpeIVzKGmwIHPlcIwh[3WudIXy[UAtKE6XTFygQUBPXUyOIN88UU4> MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN3MEm0PUc,OjB|NUC5OFk9N2F-
MDCK MYfBcpRqfmm{YXygZZN{[Xl? MlPONVI5KHWP MkLWRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYRidWGwdHHu[U1z\XOrc4ThcpQhgmGwYX3peolzNSyxc3XseIFucX[rcj3zeZNk\XC2aXLs[UBKdm[udXXufoEhSSC4aYL1d{ApSS:yZH2vUYV5cWOxL{S2NFQwOjByOTjINW4yMSliaHHyZo9zcW6pIF2yJHYzQEluIGOzNW4hdXW2YX70JIlv\mWldHXkJIlvKE2GQ1ugZ4VtdHNiYYPz[ZN{\WRiYYOg[IV1\XKvaX7heIlwdiCxZjD2bZJidCC2aYTldkBqdiClZXzsJIN2dHS3cnWgZZQhOTJ6IIXNJIFnNCCQVVzMJF0hVlWOTDFOwG0v NUnOPFhHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
MDCK MljqRY51cX[rcnHsJIF{e2G7 M3znXFEzQCC3TR?= NWP1cJo{SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WSjbXHueIFv\S2{ZYPpd5RidnRienHuZY1qfmm{LTzvd4VtfGGvaY\pdk1{fXOlZYD0bYJt\SCLbn\seYVvgmFiQTD2bZJ2eyBqQT;w[I0wS2GuaX\vdo5q[S9yND:yNFA6MEhzTkGpLUBp[XKkb4LpcochVTJiVkK4TUwhWzNzTjDteZRidnRiaX7m[YN1\WRiaX6gUWREUyClZXzsd{Bie3Onc4Pl[EBieyCmZYTldo1qdmG2aX;uJI9nKH[rcnHsJJRqfGW{IHnuJINmdGxiY4XseJVz\SCjdDCxNlghfU1iLDDOWWxNKD1iTmXMUEDPxE1w Mn3tQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|NUC5OFkoRjJyM{WwPVQ6RC:jPh?=
Vero MXPBcpRqfmm{YXygZZN{[Xl? NVjIeWV4PjRyMDD1US=> M2i4SpVxKHSxIEGyJIhzew>? MoDRRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgXYVtdG:5IH\leoVzKH[rcoXzJFE4TCCrbn\lZ5Rm\CCrbjDB[pJq[2GwIHfy[YVvKG2xbnvlfUBX\XKxIHPlcIx{KGG|c3Xzd4VlKGG|IITpcYUhemWzdXny[YQh\m:{IHnubIljcXSrb36gc4Yhfmm{YXygdoVxdGmlYYTpc44h[XRiNkSwNEB2VSC3cDD0c{AyOiCqcoOgdI9{fC24aYLhcEBqdm[nY4Tpc44tKE6XTFygQUBPXUyOIN88UU4> NHqxdVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEm1OVU{Pid-MUi5OVU2OzZ:L3G+
MDCK M37kTGFvfGm4aYLhcEBie3OjeR?= NHPub|cxKHSxIEKgbJJ{ MnzGTY5pcWKrdHnvckBw\iCrbn\seYVvgmFiQTD2bZJ2eyCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxibH;h[EB1emWjdHXkJJdqfGhiY3;tdI92dmRiYYSgNEB1dyB{IHjyd{Bxd3O2LXnu[oVkfGmxbjDifUBTXC2zUFPSJI1mfGixZDDiZZNm\CC2aX3lJI9nKGGmZHn0bY9vKGG|c3H5MEBPXUyOIE2gUnVNVCEQvF2u NIXQdlI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEG5NlU1PCd-M{CxPVI2PDR:L3G+
MDCK NGLETGpCdnSrdnnyZYwh[XO|YYm= MVq1JJRwKDhiaILz MlK4TY5pcWKrdHnvckBw\iCrbn\seYVvgmFiQTD2bZJ2eyCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxibH;h[EB1emWjdHXkJJdqfGhiY3;tdI92dmRiYYSgOUB1dyB6IHjyd{Bxd3O2LXnu[oVkfGmxbjDifUBTXC2zUFPSJI1mfGixZDDiZZNm\CC2aX3lJI9nKGGmZHn0bY9vKGG|c3H5MEBPXUyOIE2gUnVNVCEQvF2u M4LvT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUmyOVQ1Lz5|MEG5NlU1PDxxYU6=
MDCK NI\McVFCdnSrdnnyZYwh[XO|YYm= MojuNEB1dyBzMDDodpM> NX7kZYtkUW6qaXLpeIlwdiCxZjDpcoZtfWWwenGgRUB3cXK3czDpcoZm[3SnZDDpckBOTEONIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXygcI9i\CC2cnXheIVlKHerdHigZ49ueG:3bnSgZZQhOCC2bzCxNEBpenNicH;zeE1qdm[nY4Tpc44h[nliUmStdXBEWiCvZYToc4Qh[mG|ZXSgeIlu\SCxZjDh[IRqfGmxbjDhd5NigSxiTmXMUEA:KE6XTFyg{txONg>? M1jtclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUmyOVQ1Lz5|MEG5NlU1PDxxYU6=
MDCK MXXBcpRqfmm{YXygZZN{[Xl? M3fiZlIhfG9iNTDodpM> MoTiTY5pcWKrdHnvckBw\iCrbn\seYVvgmFiQTD2bZJ2eyCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxibH;h[EB1emWjdHXkJJdqfGhiY3;tdI92dmRiYYSgNkB1dyB3IHjyd{Bxd3O2LXnu[oVkfGmxbjDifUBTXC2zUFPSJI1mfGixZDDiZZNm\CC2aX3lJI9nKGGmZHn0bY9vKGG|c3H5MEBPXUyOIE2gUnVNVCEQvF2u NXf3dVE1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxPVI2PDRpPkOwNVkzPTR2PD;hQi=>
MDCK MUjBcpRqfmm{YXygZZN{[Xl? NW\hdVhvOTBidV2= NFfjOGJ2eCC2bzC4JIhzew>? M1:4b2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGlv\my3ZX76ZUBCKH[rcoXzJEhCN2OqaXPr[Y4wUHWkZXmvN|I4NzJyMESoTFVPOSlrIHnu[oVkfGWmIHnuJG1FS0tiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBm[XKueTDzeIFo\XNib3[geolz[WxicnXwcIlk[XSrb36gZZQhOTBidV2geZAhfG9iODDodpMh[nliY4L5d5RidCC4aX;s[ZQhe3SjaX7pcoch[mG|ZXSgdIxieXWnIILl[JVkfGmxbjDhd5NigSCmZYDlcoRmdnRidHnt[U1w\ixiTmXMUEA:KE6XTFyg{txONg>? NHe5eWw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEK5Nlg6Pyd-M{CyPVI5QTd:L3G+
MDCK NW[zdIxGSW62aY\pdoFtKGG|c3H5 NITVT2syODBidV2= NIfyXZIyOiCqcoO= MWXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDJcoZtfWWwenGgeolzfXNiQT;YMVMyKGmwZnXjeIVlKGmwIF3ER2sh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDvcoUh[3mlbHWgeolz[WxiUl7BJJN6dnSqZYPpd{BifCBzMECgeW0heHKnaX7jeYJifGWmIIfpeIgh[2WubIOg[o9zKDF{IHjyd{Bnd2yub4fl[EBjgSC4aYLhcEBqdm[nY4Tpc44hdWWjc4Xy[YQh[W[2ZYKgNVAhcHK|IIDvd5QhcW6oZXP0bY9vKGK7IGLUMZFRS1JibXX0bI8tKE6XTFygQUBPXUyOIN88UU4> M2nYcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OUC2N|kzLz5{OUmwOlM6OjxxYU6=
MDCK NWCybpNjSW62aY\pdoFtKGG|c3H5 M{XCXVI2OCC3TR?= MXexNEBpenN? MkS5RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTY5ndHWnborhJJZqenW|IFGvXE0{OSCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gc45mKGO7Y3zlJJZqemGuIGLORUB{gXSqZXnzJIF1KDJ3MDD1UUBi\GSnZDD0c4dmfGincjD3bZRpKH[rcoXzJIFv\CCvZXHzeZJm\CCjdDCxNEBpenNicH;zeEBqdm[nY4Tpc44h[nliUmStdXBEWiCvZYToc4QtKE6XTFygQUBPXUyOIN88UU4> NULoWFhHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm5NFY{QTJpPkK5PVA3Ozl{PD;hQi=>

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アッセイ
Methods Test Index PMID
Growth inhibition assay
Survival; 

PubMed: 26711718     


Initial dose-ranging study of ribavirin/favipiravir treatment of JUNV-infected guinea pigs. Animals in each group (n=6) were infected with 100 PFU of JUNV and treated i.p. with the indicated doses of favipiravir, ribavirin, a combination of both compounds, or placebo twice daily for 2 weeks starting 3 days p.i. Kaplan-Meier survival curves are shown. **P < 0.01, ***P < 0.001, compared to placebo-treated animals. Tx, treatment; p.i., postinfection.

Cell viability; 

PubMed: 28848019     


Reduction of WNV yield and cytotoxicity of favipiravir. (B) Percentage of viable Vero cells after favipiravir treatment. The 50% cytotoxic concentration was determined by measuring the cellular ATP content at 48 h posttreatment. Data are presented as the mean ± standard deviation (SD) from three independent determinations of both IC50 and CC50.

26711718 28848019
IHC
H&E Staining; 

PubMed: 29765101     


Histopathology and immunohistochemistry. (a) Formalin fixed tissues were embedded in paraffin and H&E stained. Images represent brains, lungs, and spleens of vehicle control animals, favipiravir p.o. and favipiravir s.c.

NiV nucleoprotein; 

PubMed: 29765101     


Histopathology and immunohistochemistry. (b) Formalin fixed tissues were embedded in paraffin and stained with anti-NiV nucleoprotein antibodies. Images represent brains, lungs, and spleens of vehicle control animals, favipiravir p.o. and favipiravir s.c. V, blood vessels; Br, bronchioles; Fo, follicles; Arrows, NiV nucleoprotein antigens.

LASV antigen; 

PubMed: 26456301     


Immunohistochemical analysis of tissues from animals infected with GPA-LASV and treated daily with favipiravir, ribavirin or placebo. Tissue samples from infected guinea pigs treated daily with favipiravir (150 or 300 mg/kg/d), ribavirin (50 mg/kg/d) or placebo were collected at 12 days post-infection and examined for the presence of LASV antigen (glycoprotein, GP) using a GP-specific monoclonal antibody according to standard immunohistochemistry techniques.

H&E stain; 

PubMed: 33037151     


(F) Representative H&E images of lungs at day 4 pi of SARS-CoV-2−infected hamsters and treated with favipiravir. At day 4, lungs of untreated hamsters show significant inflammation in bronchial wall (blue arrows) with apoptotic bodies in respiratory epithelium and extension into adjacent alveoli (orange arrow) and inflammatory cells in arterial wall (red arrow). Lungs of infected hamsters treated with 600 mg⋅kg−1⋅d−1 favipiravir still show a few inflammatory cells in the bronchial wall (blue arrows) and a few focal perivascular lymphocytes (red arrow), whereas lungs of hamsters treated with 1,000 mg⋅kg−1⋅d−1 favipiravir contain even less inflammatory cells in the bronchial wall, but no perivascular inflammation. Apoptotic bodies (black circles) were present in bronchial walls of hamsters from all three groups (Scale bars, 100 µm.)

29765101 26456301 33037151
Immunofluorescence
rNiV-Gluc; 

PubMed: 29765101     


Delayed treatment in vitro efficacy of favipiravir against NiV infection. (a) Microscopic analysis of Vero cells infected with rNiV-Gluc-eGFP (MOI 0.01). Favipiravir (250 μM) was added at 1, 12, and 24 HPI; eGFP expression, development of syncytia, and cytopathic effect were monitored by microscopy at 24, 48 and 72 HPI.

29765101
体内試験 In influenza virus-infected mice, Favipiravir (200 mg/kg/day, p.o.) protects the mice from death from influenza virus infection. [1] In mice experimentally infected with Ebola virus, Favipiravir efficiently blocks viral production, reaching an antiviral effectiveness of 95% and 99.6% at 2 and 6days after initiation of treatment, respectively. [3]

お薦めの試験操作(参考用のみ)

細胞試験: [1]
- 合併
  • 細胞株: MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells
  • 濃度: 1000 μg/mL
  • 反応時間: 3 days
  • 実験の流れ: The cytotoxicity of T-705 is evaluated by an assay with XTT. XTT is converted to aqueous formazan by an enzyme in MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells. The compounds are diluted to the appropriate concentrations (volume, 100 μl) with test medium (EMEM containing 10% FCS) in 96-well culture plates in which each well contains a concentration of 2 × 103 cells/100 μL. The test plates are incubated for 3 days at 37°C in 100% humidity and 5% CO2. After 3 days, 50 μl of the XTT reagent (1 mg/ml in FCS-free EMEM containing 5 mM phenazine methosulfate) is added, and the reaction product is assayed by measurement of the absorbance at 450 nm with a microplate reader. Cytotoxicity is expressed as the 50% cell-inhibitory concentration (CC50).
    (参考用のみ)
動物試験:[1]
- 合併
  • 動物モデル: Mice infected with influenza virus A/PR/8/34
  • 投薬量: 200 mg/kg/day
  • 投与方法: p.o.
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 31 mg/mL (197.32 mM)
Water 5 mg/mL warmed (31.82 mM)
Ethanol ''22 mg/mL warmed ''22

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 157.1
化学式

C5H4FN3O2

CAS No. 259793-96-9
Storage powder
in solvent
別名 N/A
Smiles C1=C(N=C(C(=O)N1)C(=O)N)F

投与溶媒組成計算器(クリア溶液)

ステップ1:実験データを入力してください。(実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します)
投与量 mg/kg 動物平均体重 g 投与体積(動物毎) ul 動物数
ステップ2:投与溶媒の組成を入力してください。(ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください)
% DMSO % % Tween 80 % ddH2O
計算リセット

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (mg) = 濃度 (mM) x 体積 (mL) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04907682 Recruiting Drug: Ribavirin iv|Drug: Favipiravir Lassa Fever Bernhard Nocht Institute for Tropical Medicine|University of Hamburg-Eppendorf|Alliance for International Medical Action|Institut National de la Santé Et de la Recherche Médicale France|University of Bordeaux|Federal Medical Centre Owo|Irrua Specialist Teaching Hospital July 30 2021 Phase 2
NCT04464408 Completed Drug: Favipiravir|Drug: Placebo COVID-19 King Abdullah International Medical Research Center|Ministry of Health Saudi Arabia July 23 2020 Phase 2|Phase 3

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

DNA/RNA Synthesisシグナル伝達経路

相関DNA/RNA Synthesis製品

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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID