Fluorouracil (5-Fluorouracil, 5-FU)

For research use only. Not for use in humans.

製品コードS1209 別名:NSC 19893

Fluorouracil (5-Fluorouracil, 5-FU)化学構造

CAS No. 51-21-8

Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.

サイズ 価格(税別)  
10mM (1mL in DMSO) JPY 24200
JPY 26400
JPY 38500
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バルク問合せ

文献中Selleckの製品使用例(159)

製品安全説明書

DNA/RNA Synthesis阻害剤の選択性比較

生物活性

製品説明 Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.
ターゲット
Thymidylate synthase [1]
(Tumor cells)
体外試験

Adrucil is an analogue of uracil with a fluorine atom at the C-5 position in place of hydrogen. It rapidly enters the cell using the same facilitated transport mechanism as uracil. Adrucil is converted intracellularly to several active metabolites: fluorodeoxyuridine monophosphate (FdUMP), fluorodeoxyuridine triphosphate (FdUTP) and fluorouridine triphosphate (FUTP). The Adrucil metabolite FdUMP binds to the nucleotide-binding site of TS, forming a stable ternary complex with the enzyme and CH2THF, thereby blocking binding of the normal substrate dUMP and inhibiting dTMP synthesis. Metabolite of Adrucil also can be misincorporated into DNA, leading to DNA strand breaks and cell death. The pro-apoptosis effects of Adrucil may be related to its activation of tumor suppressor p53. Loss of p53 function reduces cellular sensitivity to Adrucil. [1] Adrucil is able to inhibit the survival and induce apoptosis of a board range of cancer cells. Adrucil suppresses viabilities of the nasopharyngeal carcinoma cell line CNE2 and HONE1 [2], pancreatic cancer cell lines Capan-1 [3], and human colon carcinoma cell line HT-29 [4] with IC50 of 9 μg/mL, 3 μg/mL, 0.22 μM, 2.5 μM, respectively.

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H292 MnHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjoVWw4OsLiaNMg MU\JR|UxRiB{NTFOwIcwdUx? MnPJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyOUWxO|YoRjJ2MEm1NVc3RC:jPh?=
HL-60 Ml;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFezcmM4OsLiaNMg NHHVT21KSzVyPUiuOlAyKM7:Zz;tUC=> MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB7NUG3Okc,OjRyOUWxO|Y9N2F-
HT-29 MnTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUe3NuKhcMLi MWrJR|UxRiB{NTFOwIcwdUx? NIPaUYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC5OVE4Pid-MkSwPVUyPzZ:L3G+
MCF-7 NGDW[WpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrFdHJsPzMEoHlCpC=> MUHJR|UxRTJyIN88[{9uVA>? MmrzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyOUWxO|YoRjJ2MEm1NVc3RC:jPh?=
L1210/0 NELKNYtHfW6ldHnvckBie3OjeR?= M{DNNmVn\mWldDDvckBNOTJzMD:wJINmdGy|IHnuJIN2dHS3cnWsJGlEPTBiPTCwMlMh|ryPLh?= MoDLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MkK3PEc,OjN4MkK3PFww[T5?
CCRF-CEM MnrNSpVv[3Srb36gZZN{[Xl? MUTF[oZm[3Rib36gR2NTTi2FRV2gZ4VtdHNiaX6gZ5VtfHW{ZTygTWM2OCB;IEKg{txONg>? NIrXUpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[yNlc5Lz5{M{[yNlc5RC:jPh?=
P388 M3HjbGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NFLGTGg1QCCqcoO= M3zNPGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViUEO4PEBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD62NFkh|ryPLh?= M1z0ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{i0OFkoRjJ5N{i0OFk9N2F-
HT-29 MVzBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MVO5OkBpenN? MmXSRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKVD2yPUBk\WyuczDh[pRmeiB7NjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD62PUDPxE1w NXvrXIRGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3PFQ1QSd-Mke3PFQ1QTxxYU6=
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colon cancer cell NU\Eb2NuS3m2b4TvfIlkcXS7IHHzd4F6 NUXBeohNS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4h[2:ub36gZ4Fv[2W{IHPlcIx{NCCJSUWwJF0hPS55NTFOwG0v MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV4MkO2OUc,OTd3NkKzOlU9N2F-
A549 Mk\JR5l1d3SxeHnjbZR6KGG|c3H5 MWK0PEBpenN? M1ThR2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KEF3NEmgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDlwMjFOwG0v MkG3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4MESzPVQoRjF5NkC0N|k1RC:jPh?=
L1210 NFTpNHBEgXSxc4TheIlkKGGldHn2bZR6KGG|c3H5 NHTNWpVEgXSxc4TheIlkKGGldHn2bZR6KGGpYXnud5QhdW:3c3WgUFEzOTBiY3XscJMtKEmFNUCgQUAxNjJ6IN88UU4> NHrycYE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{mzNVg3Oid-MUe5N|E5PjJ:L3G+
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Molt4/C8 MmPKR5l1d3O2YYTpZ{Bi[3Srdnn0fUBie3OjeR?= MkPlR5l1d3O2YYTpZ{Bi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3vcJQ1N0N6IHPlcIx{NCCLQ{WwJF0hOjNizszNMi=> NVHPTXlORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5N|E5PjJpPkG3PVMyQDZ{PD;hQi=>
Caco-2 M1nSVGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NELHN|cyOCCmYYnz M3jJUWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGNi[29vMjDj[YxteyCjZoTldkAyOCCmYYnzMEBKSzVyIE2gNU42KM7:TT6= NFTlUpg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOECzO|E6PSd-MUiwN|cyQTV:L3G+
MCF7 MlvkRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MnLRN{Bl[Xm| NWDRd5lvSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDTVmIh[XO|YYmsJGlEPTBiPTC0MlMzKM7:TT6= NXzvOVBORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUiwOlkxQTNpPkG4NFY6ODl|PD;hQi=>
MCF7 MnTQRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MY\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNuIFnDOVAhRSB2LkOyJO69VS5? NWjlVJNpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUixPVQ5PjZpPkG4NVk1QDZ4PD;hQi=>
embryonic cell NG[4fpVHfW6ldHnvckBie3OjeR?= MX3JcoR2[3Srb36gc4Yh[2ynYY\h[4Uh[XK{ZYP0JIlvKGWvYoL5c45q[yClZXzsd{Bw\iC|dHHn[UA5KFinbn;weZMhdGGndnnzJIJt[XO2dXzh[UwhUUN3MDC9JFI3NjhizszNMi=> MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDJ5MUW1PEc,OTh{N{G1OVg9N2F-
HepG2 MlvhR5l1d3SxeHnjbZR6KGG|c3H5 M13SXmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{NCCLQ{WwJF0hOThwNzFOwG0v NVq1cpVvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNFI{OzZpPkG4N|AzOzN4PD;hQi=>
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HepG2 NETpenFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NGn5bFM{KGSjeYO= MXnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEincFeyJINmdGy|IHHmeIVzKDNiZHH5d{BjgSCPVGSgZZN{[XluIFnDOVAhRSB7LkKg{txONg>? MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDR{NEG1OUc,OTh2MkSxOVU9N2F-
CEM NX3WNJhjSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NGjiOVQ{KGSjeYO= MY\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEOHTTDj[YxteyCjZoTldkA{KGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hQS5{MzFOwG0v MkXmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2MkSxOVUoRjF6NEK0NVU2RC:jPh?=
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A549 NU\aPWk{S3m2b4TvfIlkcXS7IHHzd4F6 M4HNVVczKGi{cx?= MWXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC4Mlg{KM7:TT6= MmrQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ4OEe3OFUoRjJ{Nki3O|Q2RC:jPh?=
DU145 MXXDfZRwfG:6aXPpeJkh[XO|YYm= NG\R[Xg4OiCqcoO= M3zxNmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGRWOTR3IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyOi5|MjFOwG0v NEW1OXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mk[4O|c1PSd-MkK2PFc4PDV:L3G+
SGC7901 MnfZR5l1d3SxeHnjbZR6KGG|c3H5 NV2zUHRxPzJiaILz NEnZdGtEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUT0N5OUCxJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzND60PUDPxE1w NXjtT24yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2PFc4PDVpPkKyOlg4PzR3PD;hQi=>
HeLa M4TuVGN6fG:2b4jpZ4l1gSCjc4PhfS=> M2LqXVczKGi{cx?= MmHMR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVUvQTlizszNMi=> MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjZ6N{e0OUc,OjJ4OEe3OFU9N2F-
HepG2 NIHiPFVEgXSxdH;4bYNqfHliYYPzZZk> Mn3KO|IhcHK| MWjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|IvOjJizszNMi=> MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjZ6N{e0OUc,OjJ4OEe3OFU9N2F-
NCI-H460 MVnDfZRwfG:6aXPpeJkh[XO|YYm= MUi3NkBpenN? M1K1VWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KNE[wJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{LkSg{txONg>? M1nGOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{K3OFQ2Lz5{MkeyO|Q1PTxxYU6=
BGC823 MYHDfZRwfG:6aXPpeJkh[XO|YYm= NG\TPWY4OiCqcoO= MmG5R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRmdEQDJ|IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA1NjVizszNMi=> NET5coM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkeyO|Q1PSd-MkK3Nlc1PDV:L3G+
HepG2 MlvGR5l1d3SxeHnjbZR6KGG|c3H5 MXq3NkBpenN? MX\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOE45KM7:TT6= MmHFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5Mke0OFUoRjJ{N{K3OFQ2RC:jPh?=
SGC7901 M2jQW2N6fG:2b4jpZ4l1gSCjc4PhfS=> MUG3NkBpenN? NE\OT4FEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUT0N5OUCxJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB4LkOg{txONg>? MorYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5Mke0OFUoRjJ{N{K3OFQ2RC:jPh?=
MCF7 NILvN2ZEgXSxdH;4bYNqfHliYYPzZZk> MnfMO|IhcHK| NXriN|FYS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTJwNTFOwG0v NV65TnE5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK3Nlc1PDVpPkKyO|I4PDR3PD;hQi=>
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MCF7 MnT6R5l1d3SxeHnjbZR6KGG|c3H5 NVG0WYpVPzJiaILz NVO0cXZ6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTRwMjFOwG0v MnH2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5NEmxPVIoRjJ{N{S5NVkzRC:jPh?=
CNE2 MliwR5l1d3SxeHnjbZR6KGG|c3H5 MmfRO|IhcHK| M{TYNWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNPTTJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE2NjFizszNMi=> NFm0UHc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mke0PVE6Oid-MkK3OFkyQTJ:L3G+
GLC82 NHvZV4tEgXSxdH;4bYNqfHliYYPzZZk> MUe3NkBpenN? MlPiR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gS2xEQDJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE4NjRizszNMi=> NGfwRYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mke0PVE6Oid-MkK3OFkyQTJ:L3G+
MGC803 NX7WZ5E2S3m2b4TvfIlkcXS7IHHzd4F6 NIPL[2Q4OiCqcoO= MVHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNS2M5ODNiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE5NjVizszNMi=> MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjd2OUG5Nkc,OjJ5NEmxPVI9N2F-
MCF7 MUTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M3;GeVczKGi{cx?= MXPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KGO{eYP0ZYwhfmmxbHX0JJN1[WmwaX7nJI1mfGixZDygTWM2OCB;IESuO{DPxE1w MoX6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5NkW4PVcoRjJ{N{[1PFk4RC:jPh?=
HT-29 MkjQRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MW[3NkBpenN? NHfrRpVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjUMVI6KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yCvZYToc4QtKEmFNUCgQUA4NjNizszNMi=> NF3Xe4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mke2OVg6Pyd-MkK3OlU5QTd:L3G+
MDA-MB-231 NITzW2RCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MmfFO|IhcHK| NH:zfoxCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KGO{eYP0ZYwhfmmxbHX0JJN1[WmwaX7nJI1mfGixZDygTWM2OCB;IEmuOkDPxE1w NGf5[lk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mke2OVg6Pyd-MkK3OlU5QTd:L3G+
HT1080 Mof4R5l1d3SxeHnjbZR6KGG|c3H5 NH\ES5FEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJXDFyOECgZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN{4xPiEQvF2u NXPnR|JtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4NFE3PDRpPkKyPFAyPjR2PD;hQi=>
A375-S2 NUPHXpduS3m2b4TvfIlkcXS7IHHzd4F6 MV7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBN|c2NVN{IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEmuPVIh|ryPLh?= NEeye449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwNVY1PCd-MkK4NFE3PDR:L3G+
HeLa MWTDfZRwfG:6aXPpeJkh[XO|YYm= MX\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFyLkO2JO69VS5? NH7yUIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwNVY1PCd-MkK4NFE3PDR:L3G+
HepG2 NWqyNmQyS3m2b4TvfIlkcXS7IHHzd4F6 MoL3R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUCuOFUh|ryPLh?= NGHnPZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwNVY1PCd-MkK4NFE3PDR:L3G+
BGC823 M{TtWGN6fG:2b4jpZ4l1gSCjc4PhfS=> NFrQTpZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBDT0N6MkOgZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVUvPjVizszNMi=> MmX1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6MEG2OFQoRjJ{OECxOlQ1RC:jPh?=
Hep2 MY\DfZRwfG:6aXPpeJkh[XO|YYm= M{LaUmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeDJiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkSuOVgh|ryPLh?= NEfxbFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwNVY1PCd-MkK4NFE3PDR:L3G+
MCF7 NFPPfldEgXSxdH;4bYNqfHliYYPzZZk> MmLNR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{ND61PEDPxE1w MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjhyMU[0OEc,OjJ6MEG2OFQ9N2F-
A549 M{TKU2N6fG:2b4jpZ4l1gSCjc4PhfS=> NULBe|BZS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzNU42OiEQvF2u NEPhSII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwNVY1PCd-MkK4NFE3PDR:L3G+
MDA231 NHjBdGxEgXSxdH;4bYNqfHliYYPzZZk> MnHuR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCOjNzIHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOxMlU4KM7:TT6= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjhyMU[0OEc,OjJ6MEG2OFQ9N2F-
PC3 NYnvZ4dUS3m2b4TvfIlkcXS7IHHzd4F6 M1PwW2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBEOyClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB|NT63OUDPxE1w MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjhyMU[0OEc,OjJ6MEG2OFQ9N2F-
PC3M NX\LNmNFS3m2b4TvfIlkcXS7IHHzd4F6 NH\Cd2c1QCCqcoO= NULVPYNzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEN|TTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjJwNkOg{txONg>? NUKzTotpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4NFk2PThpPkKyPFA6PTV6PD;hQi=>
A549 M{fmZmN6fG:2b4jpZ4l1gSCjc4PhfS=> Mm\yOFghcHK| MmLaR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|UvPDFizszNMi=> MorKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6MEm1OVgoRjJ{OEC5OVU5RC:jPh?=
MKN45 M1LyOmN6fG:2b4jpZ4l1gSCjc4PhfS=> NFy2[2I1QCCqcoO= MXPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNT241PSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOFEvPzNizszNMi=> MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjhyOUW1PEc,OjJ6MEm1OVg9N2F-
HepG2 MmSxR5l1d3SxeHnjbZR6KGG|c3H5 Ml;6OFghcHK| MXfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOFYvQDNizszNMi=> NUfwT2c1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4NFk2PThpPkKyPFA6PTV6PD;hQi=>
LoVo NV2xRXFFSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NYnmTXJoPDhiaILz NV;OelhLSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDMc3ZwKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzMlMh|ryPLh?= M1PRfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OESwOFk{Lz5{Mki0NFQ6OzxxYU6=
A549 NHXwW4lCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MWm0PEBpenN? NEfINZlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGyMlgh|ryPLh?= NIW3WVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mki0NFQ6Oyd-MkK4OFA1QTN:L3G+
MCF7 NFuyU|JCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MmDpOFghcHK| M1vvcmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMU[uNkDPxE1w MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh2MES5N{c,OjJ6NEC0PVM9N2F-
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2008 M2W2Rmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVzHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjCyNFA5KGOnbHzzJIJ6KGO{eYP0ZYwhfmmxbHX0JIF{e2G7LDDJR|UxKD1iND6yJO69VS5? NXLvNGtxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwO|U1OTRpPkKzNFc2PDF2PD;hQi=>
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MCF7 MXvDfZRwfG:6aXPpeJkh[XO|YYm= NGfURXY4OiCqcoO= NGK0eYREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyPy5{IN88UU4> NH\sZ5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K3PVg3PCd-MkOyO|k5PjR:L3G+
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HCT116 MVLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MYS0PEBpenN? MVHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKGOnbHygdJJwdGmoZYLheIlwdiCjZoTldkA1QCCqcoOgZpkhW3WuZn;ybI9l[W2rbnWgRkBie3OjeTygTWM2OCB;IEOuOVYh|ryPLh?= M2jNbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{C1PVE6Lz5{M{OwOVkyQTxxYU6=
B16F10 MkHBRY51cWOjbnPldkBie3OjeR?= MUS0PEBpenN? NFTxUJJCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhdW:3c3WgRlE3TjFyIHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwhe3W{dnn2ZYwhdWWjc4Xy[YQh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFIyNjRzIN88UU4> NVzHXpBSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVI6PDlpPkKzN|EzQTR7PD;hQi=>
SGC7901 NITDelBCdnSrY3HuZ4VzKGG|c3H5 MUm0PEBpenN? NH2zflZCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gV2dEPzlyMTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKHO3co\peoFtKG2nYYP1doVlKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA1Pi5|NTFOwG0v NULVZmNNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVI6PDlpPkKzN|EzQTR7PD;hQi=>
HeLa NXfzcYVxSW62aYT1cY9zKGG|c3H5 NGq3TXU1QCCqcoO= MV;BcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZVzhJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJI1m[XO3cnXkJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxOE44QCEQvF2u M{e0T|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM2Lz5{M{OxN|Y{PTxxYU6=
A549 NG\4eFhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVThd3NmPDhiaILz NX;LW215T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hSTV2OTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPS54NDFOwG0v MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzN3M{ezO{c,OjN|NUO3N|c9N2F-
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MCF7 MoGyR5l1d3SxeHnjbZR6KGG|c3H5 NIXGXI84OiCqcoO= NVu0WJhRS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNz61OEDPxE1w Mmf6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|NUO3OFMoRjJ|M{WzO|Q{RC:jPh?=
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leukemia M3myc2N6fG:2b4jpZ4l1gSCjc4PhfS=> NFr4SWE1QCCqcoO= NH;rbIlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBt\XWtZX3pZUBk\WyuczDh[pRmeiB2ODDodpMh[nlic4XsdIhwemixZHHtbY5mKEJiYYPzZZktKEeLNUCgQUAyPS5zIN88UU4> NFmydZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S3OFg6QSd-MkO0O|Q5QTl:L3G+
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renal cancer NXrFZ2F[S3m2b4TvfIlkcXS7IHHzd4F6 M3HucFQ5KGi{cx?= MV3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDy[Y5idCClYX7j[ZIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IIP1cJBpd3Kqb3ThcYlv\SCEIHHzd4F6NCCJSUWwJF0hPDVwNjFOwG0v NFTOPWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S3OFg6QSd-MkO0O|Q5QTl:L3G+
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HepG2 NWjseIc1S3m2b4TvfIlkcXS7IHHzd4F6 MV60PEBpenN? MojwR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFIzNjhizszNMi=> MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzR7MEG1PUc,OjN2OUCxOVk9N2F-
SGC7901 NUTNRWVsS3m2b4TvfIlkcXS7IHHzd4F6 MlPHOFghcHK| MVnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTS2M4QTBzIHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzQC57IN88UU4> NE\CRpk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S5NFE2QSd-MkO0PVAyPTl:L3G+
THP1 MmfiRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? Mo\5OFghcHK| M4nHfGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iVFjQNUBk\WyuczDh[pRmeiB2ODDodpMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhUUN3MDC9JFEh|ryPLh?= NH;LTIs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{WwNVEyOyd-MkO1NFEyOTN:L3G+
PC3 NYq2NoVXSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MYq0PEBpenN? MU\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFCFMzDj[YxteyCjZoTldkA1QCCqcoOgZpkhe3WuZn;ybI9l[W2rbnWgRkBie3OjeTygTWM2OCB;IEKuNkDPxE1w M{XpSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NUCxNVE{Lz5{M{WwNVEyOzxxYU6=
Hep2 MkH0RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MVi0PEBpenN? NFKyUldCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldFIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IIP1cIZwemixZHHtbY5mKEJiYYPzZZktKEmFNUCgQUA1NjVizszNMi=> MmPSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3MEGxNVMoRjJ|NUCxNVE{RC:jPh?=
A549 MWXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MUi0PEBpenN? NFjiTXhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IIP1cIZwemixZHHtbY5mKEJiYYPzZZktKEmFNUCgQUA1NjlizszNMi=> MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzVyMUGxN{c,OjN3MEGxNVM9N2F-
K562 NEju[W9EgXSxdH;4bYNqfHliYYPzZZk> M3jYOlczKGi{cx?= NF;ybW1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzQCEQvF2u M2Duc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NUO1N|IzLz5{M{WzOVMzOjxxYU6=
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