Fluorouracil (5-Fluorouracil, 5-FU)

For research use only. Not for use in humans.

製品コードS1209 別名:NSC 19893

Fluorouracil (5-Fluorouracil, 5-FU)化学構造

CAS No. 51-21-8

Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.

サイズ 価格(税別)  
10mM (1mL in DMSO) JPY 24200
JPY 26400
JPY 38500
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バルク問合せ

文献中Selleckの製品使用例(137)

製品安全説明書

DNA/RNA Synthesis阻害剤の選択性比較

生物活性

製品説明 Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.
ターゲット
Thymidylate synthase [1]
(Tumor cells)
体外試験

Adrucil is an analogue of uracil with a fluorine atom at the C-5 position in place of hydrogen. It rapidly enters the cell using the same facilitated transport mechanism as uracil. Adrucil is converted intracellularly to several active metabolites: fluorodeoxyuridine monophosphate (FdUMP), fluorodeoxyuridine triphosphate (FdUTP) and fluorouridine triphosphate (FUTP). The Adrucil metabolite FdUMP binds to the nucleotide-binding site of TS, forming a stable ternary complex with the enzyme and CH2THF, thereby blocking binding of the normal substrate dUMP and inhibiting dTMP synthesis. Metabolite of Adrucil also can be misincorporated into DNA, leading to DNA strand breaks and cell death. The pro-apoptosis effects of Adrucil may be related to its activation of tumor suppressor p53. Loss of p53 function reduces cellular sensitivity to Adrucil. [1] Adrucil is able to inhibit the survival and induce apoptosis of a board range of cancer cells. Adrucil suppresses viabilities of the nasopharyngeal carcinoma cell line CNE2 and HONE1 [2], pancreatic cancer cell lines Capan-1 [3], and human colon carcinoma cell line HT-29 [4] with IC50 of 9 μg/mL, 3 μg/mL, 0.22 μM, 2.5 μM, respectively.

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H292 NWHhdJFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXzO|LDqGkEoB?= M1zRXWlEPTB-IEK1JO69\y:vTB?= MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB7NUG3Okc,OjRyOUWxO|Y9N2F-
HL-60 NYmwSHVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nINlczyqCqwrC= NEXsTYlKSzVyPUiuOlAyKM7:Zz;tUC=> NX\3[W9kRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwPVUyPzZpPkK0NFk2OTd4PD;hQi=>
HT-29 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGixUmM4OsLiaNMg M1fKcWlEPTB-IEK1JO69\y:vTB?= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB7NUG3Okc,OjRyOUWxO|Y9N2F-
MCF-7 NXHEZlFDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTqOZlDPzMEoHlCpC=> MmnPTWM2OD1{MDFOwIcwdUx? M4P6UFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEm1NVc3Lz5{NEC5OVE4PjxxYU6=
L1210/0 NY[x[nBpTnWwY4Tpc44h[XO|YYm= MnjRSYZn\WO2IH;uJGwyOjFyL{CgZ4VtdHNiaX6gZ5VtfHW{ZTygTWM2OCB;IECuN{DPxE1w M2TJUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkKyO|goRjJ|NkKyO|g9N2F-
CCRF-CEM NYjLdYRGTnWwY4Tpc44h[XO|YYm= M{X1WGVn\mWldDDvckBES1KILVPFUUBk\WyuczDpckBkfWy2dYLlMEBKSzVyIE2gNkDPxE1w MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ{Mke4K|4zOzZ{Mke4QE9iRg>?
P388 NGXFOmpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M1rvPFQ5KGi{cx?= M1;sRWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViUEO4PEBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD62NFkh|ryPLh?= NUT2SVBURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3PFQ1QSd-Mke3PFQ1QTxxYU6=
HT-29 M3LqZ2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MlrRPVYhcHK| M1TRVGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSGStNlkh[2WubIOgZYZ1\XJiOU[gbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuOlkh|ryPLh?= MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd6NES5K|4zPzd6NES5QE9iRg>?
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SW480 M3\CeGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NF7Tfnk4OiCqcoO= MlXjRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVV{S4NEBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJI1mfGixZDygTWM2OCB;IEiuNUDPxE1w NHz2NZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{WyOFY2PSd-MUe1NlQ3PTV:L3G+
MDA-MB-435S M1LMUWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 Ml\DO|IhcHK| NIP5PXpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi12M{XTJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgcYV1cG:mLDDJR|UxKD1iMUSuOUDPxE1w M1r0[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUK0OlU2Lz5zN{WyOFY2PTxxYU6=
HCCLM7 M33LcWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 Mly1O|IhcHK| MUDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFQ1zNO{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJI1mfGixZDygTWM2OCB;IEG4MlYh|ryPLh?= MlrUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3MkS2OVUoRjF5NUK0OlU2RC:jPh?=
Caco-2 M3jye2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWOyblFCT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hS2Glbz2yJINmdGy|LDDJR|UxKD1iMT61JO69VS5? MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV2OEGyPUc,OTd3NEixNlk9N2F-
MCF7 NVjqcY9QSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MlzZO|IhcHK| M1rTbWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB5MjDodpMtKEmFNUCgQUAxNjNizszNMi=> MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV2OEG5PEc,OTd3NEixPVg9N2F-
HCT116 MYrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M2HtfFczKGi{cx?= NUTMXYVkSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgO|IhcHK|LDDJR|UxKD1iMj64JO69VS5? M{\IOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUS4NVk5Lz5zN{W0PFE6QDxxYU6=
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DLD1 MmnwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MY\Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDEUGQyKGOnbHzzMEBKSzVyIE2gOE42KM7:TT6= Mn;mQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NUO2PFUoRjF5NUWzOlg2RC:jPh?=
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A549 M4DLT2N6fG:2b4jpZ4l1gSCjc4PhfS=> MVu0PEBpenN? MYrDfZRwfG:6aXPpeJkh[WejaX7zeEBCPTR7IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA6NjJizszNMi=> NFrVN|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[wOFM6PCd-MUe2NFQ{QTR:L3G+
L1210 Ml60R5l1d3O2YYTpZ{Bi[3Srdnn0fUBie3OjeR?= M{WwRmN6fG:|dHH0bYMh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDMNVIyOCClZXzsd{whUUN3MDC9JFAvOjhizszNMi=> M1HiflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OUOxPFYzLz5zN{mzNVg3OjxxYU6=
CEM NYTQZ2ZWS3m2b4P0ZZRq[yCjY4Tpeol1gSCjc4PhfS=> M4[wWGN6fG:|dHH0bYMh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDDSW0h[2WubIOsJGlEPTBiPTC5JO69VS5? MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzl|MUi2Nkc,OTd7M{G4OlI9N2F-
Molt4/C8 M1zMZWN6fG:|dHH0bYMh[WO2aY\peJkh[XO|YYm= MW\DfZRwe3SjdHnjJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTX;seFQwSzhiY3XscJMtKEmFNUCgQUAzOyEQvF2u M2L0NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OUOxPFYzLz5zN{mzNVg3OjxxYU6=
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embryonic cell NYL3cI9QTnWwY4Tpc44h[XO|YYm= NEL0WHJKdmS3Y4Tpc44hd2ZiY3zlZZZi\2ViYYLy[ZN1KGmwIHXtZpJ6d26rYzDj[YxteyCxZjDzeIFo\SB6IGjlco9xfXNibHHleol{KGKuYYP0eYxi\SxiSVO1NEA:KDJ4Lkig{txONg>? MnvyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh{N{G1OVgoRjF6MkexOVU5RC:jPh?=
HepG2 MmLYR5l1d3SxeHnjbZR6KGG|c3H5 NX2xW3c3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNuIFnDOVAhRSBzOD63JO69VS5? NH;aNFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEOwNlM{Pid-MUizNFI{OzZ:L3G+
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HepG2 NYPUVY5lSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MW[zJIRigXN? MUTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEincFeyJINmdGy|IHHmeIVzKDNiZHH5d{BjgSCPVGSgZZN{[XluIFnDOVAhRSB7LkKg{txONg>? Mkj6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2MkSxOVUoRjF6NEK0NVU2RC:jPh?=
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HeLa NGDYSpNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MVKzJIRigXN? Mn25RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZVzhJINmdGy|IHHmeIVzKDNiZHH5d{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzNjFOwG0v MmTnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2MkSxOVUoRjF6NEK0NVU2RC:jPh?=
Molt4/C8 NWf5[nJySW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M1;rSlMh\GG7cx?= M1LjZ2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTX;seFQwSzhiY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFIxKM7:TT6= NVHrPWNvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0NlQyPTVpPkG4OFI1OTV3PD;hQi=>
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A549 M3TPfmN6fG:2b4jpZ4l1gSCjc4PhfS=> NXHJbHl2PzJiaILz NEftdHBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA6NjF7IN88UU4> NWm1R5lMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0OFAzOzNpPkG4OFQxOjN|PD;hQi=>
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Patu-02 MnvMR5l1d3SxeHnjbZR6KGG|c3H5 NIPteXFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBR[XS3LUCyJINmdGy|IHL5JINzgXO2YXygeolwdGW2IIP0ZYlvcW6pLDDJR|UxKD1iMz65OUDPxE1w MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODl|MEGyN{c,OjB7M{CxNlM9N2F-
DAN-G MU\DfZRwfG:6aXPpeJkh[XO|YYm= NIH1cGxEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBFSU5vRzDj[YxteyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yxiSVO1NEA:KDRwM{ig{txONg>? NGTJS4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEmzNFEzOyd-MkC5N|AyOjN:L3G+
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Hep2 NHe0dppCdnSrY3HuZ4VzKGG|c3H5 NYr2dIdbPDhiaILz NWTvbmV6SW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJGhmeDJiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFAvOyEQvF2u M4XmflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMEe0OFQ1Lz5{MUC3OFQ1PDxxYU6=
A549 NEfaXFlCdnSrY3HuZ4VzKGG|c3H5 NXrVVFJsPDhiaILz Mle4RY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygTWM2OCB;IEKuOEDPxE1w MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB5NES0OEc,OjFyN{S0OFQ9N2F-
HCT15 NWD0[JRtSW62aXPhcoNmeiCjc4PhfS=> M3rISVQ5KGi{cx?= MnfWRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFE2KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCzMlYh|ryPLh?= MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB5NES0OEc,OjFyN{S0OFQ9N2F-
502713 M4HG[mFvfGmlYX7j[ZIh[XO|YYm= NHnJNmc1QCCqcoO= MnK0RY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIEWwNlcyOyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gOE43KM7:TT6= NW\kZ3dORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwO|Q1PDRpPkKxNFc1PDR2PD;hQi=>
DU145 NUDDbG0ySW62aXPhcoNmeiCjc4PhfS=> NGLJflI1QCCqcoO= NH;VZYtCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gSHUyPDViY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFQvQCEQvF2u NV7tblk5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwO|Q1PDRpPkKxNFc1PDR2PD;hQi=>
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CEM M2LJcGN6fG:|dHH0bYMh[WO2aY\peJkh[XO|YYm= MnHMR5l1d3O2YYTpZ{Bi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFPFUUBk\WyuczygTWM2OCB;IEG4JO69VS5? MkG4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7MUezOlMoRjJzOUG3N|Y{RC:jPh?=
A549 MVnDfZRwfG:6aXPpeJkh[XO|YYm= MorQN{Bl[Xm| Mm\vR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjCzJIRigXNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNE41OiEQvF2u NHnNPWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkCwNFkzPSd-MkKwNFA6OjV:L3G+
HepG2 NVq1XolES3m2b4TvfIlkcXS7IHHzd4F6 NInZUmM{KGSjeYO= MVvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjCzJIRigXNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNk44KM7:TT6= MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjByMEmyOUc,OjJyMEC5NlU9N2F-
BCG823 NX\Rd|J5S3m2b4TvfIlkcXS7IHHzd4F6 M1j3U|Mh\GG7cx?= MXPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCR2c5OjNiY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFYvOTVizszNMi=> MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjByMEmyOUc,OjJyMEC5NlU9N2F-
colon cancer cell MYPDfZRwfG:6aXPpeJkh[XO|YYm= NX\qW2xZPDhiaILz MVrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDjc4xwdiClYX7j[ZIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IHPveYx1\XJiY3;1cpRqdmduIFfJOVAhRSB6LkSg{txONg>? Mlf4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyNU[yO|coRjJ{MEW2Nlc4RC:jPh?=
leukemia cell NX2zeYZTS3m2b4TvfIlkcXS7IHHzd4F6 MXy0PEBpenN? NYLuRpdMS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hdGW3a3XtbYEh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IHPveYx1\XJiY3;1cpRqdmduIFfJOVAhRSBzNT6xJO69VS5? MlrvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyNU[yO|coRjJ{MEW2Nlc4RC:jPh?=
prostate cancer cell NETLWHdEgXSxdH;4bYNqfHliYYPzZZk> NYTROphPPDhiaILz NEfjTotEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBxem:|dHH0[UBk[W6lZYKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KGOxdXz0[ZIh[2:3boTpcoctKEeLNUCgQUAzOi55IN88UU4> NHT4[249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkC1OlI4Pyd-MkKwOVYzPzd:L3G+
renal cancer cell MnjSR5l1d3SxeHnjbZR6KGG|c3H5 MlrKOFghcHK| NHj1PFFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBz\W6jbDDjZY5k\XJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JINwfWy2ZYKgZ492dnSrbnesJGdKPTBiPTC0OU43KM7:TT6= NHXxe449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkC1OlI4Pyd-MkKwOVYzPzd:L3G+
MCF7 NHnTd2dCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NGHhToY4OiCqcoO= Mnm5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB7Lk[3JO69VS5? NV3QW3BTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwO|k{PzhpPkKyNFc6Ozd6PD;hQi=>
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GLC82 NX;XfnFESW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NUjzfG9HPzJiaILz NVnkbWpESW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDHUGM5OiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVUvPSEQvF2u MofFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyN{mzO|goRjJ{MEe5N|c5RC:jPh?=
MGC803 M3G0O2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MYS3NkBpenN? MXLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2JQ{iwN{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMU[uOkDPxE1w MkTDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyN{mzO|goRjJ{MEe5N|c5RC:jPh?=
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HEK293 MnG0R5l1d3SxeHnjbZR6KGG|c3H5 MYGyJIRigXN? M1fBT2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhGUzJ7MzDj[YxteyCjZoTldkAzKGSjeYOgZpkh[WyjbXHyJIJtfWViYYPzZZktKEmFNUCgQUA1Oi57IN88UU4> NFPyO|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkC5N|c3OSd-MkKwPVM4PjF:L3G+
colon cancer cell NXPnNW1bT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{DTPFQ5KGi{cx?= MYTHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDjc4xwdiClYX7j[ZIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IHPveYx1\XJiY3;1cpRmeiCvZYToc4QtKEeLNUCgQUA5NjRizszNMi=> MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjFzOUG1NUc,OjJzMUmxOVE9N2F-
leukemia cell NIW4Z|dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mn[4OFghcHK| M1\tSWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJIxmfWunbXnhJINmdGy|IHHmeIVzKDR6IHjyd{BjgSClb4XseIVzKGOxdX70[ZIhdWW2aH;kMEBIUTVyIE2gNVUvOSEQvF2u MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjFzOUG1NUc,OjJzMUmxOVE9N2F-
prostate cancer cell NIX1PWlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4m5NlQ5KGi{cx?= NWfOOJRyT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4heHKxc4TheIUh[2GwY3XyJINmdGy|IHHmeIVzKDR6IHjyd{BjgSClb4XseIVzKGOxdX70[ZIhdWW2aH;kMEBIUTVyIE2gNlIvPyEQvF2u NULMR4JwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxNVkyPTFpPkKyNVE6OTVzPD;hQi=>
renal cancer cell NVnNVJlkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3rxNVQ5KGi{cx?= Mor2S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gdoVv[WxiY3HuZ4VzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDjc5VtfGW{IHPveY51\XJibXX0bI9lNCCJSUWwJF0hPDVwNjFOwG0v NGTqO4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGxPVE2OSd-MkKxNVkyPTF:L3G+
H460 M4HCWGN6fG:2b4jpZ4l1gSCjc4PhfS=> NYXzcINGPzJiaILz NUW5[GFuS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUDR4MDDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOyEQvF2u NUTMZ5FQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxN|AyOzJpPkKyNVMxOTN{PD;hQi=>
HCT116 MWXDfZRwfG:6aXPpeJkh[XO|YYm= NFywdIM4OiCqcoO= MkjyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTF4IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA1KM7:TT6= MnThQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzM{CxN|IoRjJ{MUOwNVMzRC:jPh?=
MCF7 NInaUW5EgXSxdH;4bYNqfHliYYPzZZk> NE[4RXQ4OiCqcoO= NF3YPY5EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyPCEQvF2u NGj5R489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGzNFE{Oid-MkKxN|AyOzJ:L3G+
A549 NYHlXFJrS3m2b4TvfIlkcXS7IHHzd4F6 NV7rT5gxOjRiaILz M3vye2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFUvPjRizszNMi=> M4HabVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUiyPVI3Lz5{MkG4NlkzPjxxYU6=
QGY7701 MXzDfZRwfG:6aXPpeJkh[XO|YYm= NHrJXYIzPCCqcoO= MXrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDRS3k4PzBzIHPlcIx{KGGodHXyJFI1KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyPC5|IN88UU4> MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF6MkmyOkc,OjJzOEK5NlY9N2F-
SW480 NYrDXpVbS3m2b4TvfIlkcXS7IHHzd4F6 M{DYcVI1KGi{cx?= NUDVeVNtS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW1d2OECgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF3LkexJO69VS5? NVjvPFVtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxPFI6OjZpPkKyNVgzQTJ4PD;hQi=>
HeLa NVG5Xm9XS3m2b4TvfIlkcXS7IHHzd4F6 MmrPNlQhcHK| MnTTR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{Bi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVYvOzJizszNMi=> MnTsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzOEK5NlYoRjJ{MUiyPVI3RC:jPh?=
KB M3rvcWN6fG:2b4jpZ4l1gSCjc4PhfS=> NIjlUoo4OiCqcoO= M4e5T2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGtDKGOnbHzzJIFnfGW{IEeyJIhzeyCweTDNWHQh[XO|YYmsJGlEPTBiPTC5JO69VS5? MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJyMESwOEc,OjJ{MEC0NFQ9N2F-
CNE2 M3P2W2N6fG:2b4jpZ4l1gSCjc4PhfS=> NYXWTW1GPzJiaILz M4q3[GN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNPTTJiY3XscJMh[W[2ZYKgO|IhcHK|IH75JG1VXCCjc4PhfUwhUUN3MDC9JFE{NjVizszNMi=> M1Xh[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkCwOFA1Lz5{MkKwNFQxPDxxYU6=
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NCI-H460 MlvwR5l1d3SxeHnjbZR6KGG|c3H5 NXvpUVdCS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVkOLLVi0OlAh[2WubIOsJGlEPTBiPTC4JO69VS5? NYfiOo9FRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyPFM1PTFpPkKyNlg{PDVzPD;hQi=>
SMMC7721 M2\UXmN6fG:2b4jpZ4l1gSCjc4PhfS=> M1vPN2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNOVUN5N{KxJINmdGy|LDDJR|UxKD1iMUWg{txONg>? NGjlcpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkK4N|Q2OSd-MkKyPFM1PTF:L3G+
MCF7 M{nR[mN6fG:2b4jpZ4l1gSCjc4PhfS=> M3fm[GN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMtKEmFNUCgQUA{OSEQvF2u MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ6M{S1NUc,OjJ{OEO0OVE9N2F-
NCI-H460 NHq3XppEgXSxdH;4bYNqfHliYYPzZZk> NX\lVll4PDhiaILz NGmze25EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvSES2NEBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkmg{txONg>? M{DPNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{C0N|Q1Lz5{MkOwOFM1PDxxYU6=
B16 Mn\PR5l1d3SxeHnjbZR6KGG|c3H5 MV20PEBpenN? NID5dGtEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBDOTZiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFM{KM7:TT6= NIXDbpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOwOFM1PCd-MkKzNFQ{PDR:L3G+
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HepG2 NIPlNYVEgXSxdH;4bYNqfHliYYPzZZk> M13vXlczKGi{cx?= NEP0PJlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOzJwMkKg{txONg>? MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjZ6N{e0OUc,OjJ4OEe3OFU9N2F-
NCI-H460 M{[3XGN6fG:2b4jpZ4l1gSCjc4PhfS=> NUCzZXRzPzJiaILz M{fnRWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KNE[wJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{LkSg{txONg>? M{fCZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{K3OFQ2Lz5{MkeyO|Q1PTxxYU6=
BGC823 MmfsR5l1d3SxeHnjbZR6KGG|c3H5 MWq3NkBpenN? M17KXWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJISzh{MzDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPC53IN88UU4> M2nTfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{K3OFQ2Lz5{MkeyO|Q1PTxxYU6=
HepG2 MoTzR5l1d3SxeHnjbZR6KGG|c3H5 M3j3[|czKGi{cx?= MX\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOE45KM7:TT6= M4rr[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{K3OFQ2Lz5{MkeyO|Q1PTxxYU6=
SGC7901 Ml7HR5l1d3SxeHnjbZR6KGG|c3H5 MmDBO|IhcHK| NV\WSnozS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0eFN{mwNUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNj6zJO69VS5? MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjd{N{S0OUc,OjJ5Mke0OFU9N2F-
MCF7 MlnMR5l1d3SxeHnjbZR6KGG|c3H5 MXW3NkBpenN? M4W1cGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEzNjVizszNMi=> NFnWVI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkeyO|Q1PSd-MkK3Nlc1PDV:L3G+
KB NYHOfnlIS3m2b4TvfIlkcXS7IHHzd4F6 NYLOdHhmPzJiaILz MorVR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT2Ih[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEiuNlgh|ryPLh?= Mnf0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5NEmxPVIoRjJ{N{S5NVkzRC:jPh?=
MCF7 M1HZPGN6fG:2b4jpZ4l1gSCjc4PhfS=> M3r5clczKGi{cx?= NGHwZ4VEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyPC5{IN88UU4> NGPxNmQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mke0PVE6Oid-MkK3OFkyQTJ:L3G+
CNE2 NV;6NmN3S3m2b4TvfIlkcXS7IHHzd4F6 Ml7sO|IhcHK| MYXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDUmUzKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxOU4yKM7:TT6= M1;M[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{S5NVkzLz5{Mke0PVE6OjxxYU6=
GLC82 M4\xPWN6fG:2b4jpZ4l1gSCjc4PhfS=> MkThO|IhcHK| Mn\MR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gS2xEQDJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE4NjRizszNMi=> MoD4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5NEmxPVIoRjJ{N{S5NVkzRC:jPh?=
MGC803 NH;Fe5lEgXSxdH;4bYNqfHliYYPzZZk> NFrneWI4OiCqcoO= NGC5fIlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOT0N6MEOgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF6LkWg{txONg>? MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjd2OUG5Nkc,OjJ5NEmxPVI9N2F-
MCF7 MnvGRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NWHSOGxNPzJiaILz NGXDPGtCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IHPyfZN1[WxidnnvcIV1KHO2YXnubY5oKG2ndHjv[EwhUUN3MDC9JFQvPyEQvF2u NFvBUGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mke2OVg6Pyd-MkK3OlU5QTd:L3G+
HT-29 NYG3ZnY{SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NG\ZRpQ4OiCqcoO= MkCwRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKVD2yPUBk\WyuczDh[pRmeiB5MjDodpMh[nliY4L5d5RidCC4aX;s[ZQhe3SjaX7pcochdWW2aH;kMEBKSzVyIE2gO{4{KM7:TT6= NHzwXJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mke2OVg6Pyd-MkK3OlU5QTd:L3G+
MDA-MB-231 NGDpZnBCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NYjoXVl7PzJiaILz NVm5TJRUSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDd{IHjyd{BjgSClconzeIFtKH[rb3zleEB{fGGrbnnu[{Bu\XSqb3SsJGlEPTBiPTC5MlYh|ryPLh?= M{KycFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{[1PFk4Lz5{Mke2OVg6PzxxYU6=
HT1080 MkD6R5l1d3SxeHnjbZR6KGG|c3H5 M{fEdGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhVOTB6MDDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzMlA3KM7:TT6= MkLiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6MEG2OFQoRjJ{OECxOlQ1RC:jPh?=
A375-S2 MV7DfZRwfG:6aXPpeJkh[XO|YYm= NF7tb3lEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCOzd3LWOyJINmdGy|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFkvQTJizszNMi=> M4HLNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OECxOlQ1Lz5{MkiwNVY1PDxxYU6=
HeLa NWHzb5BGS3m2b4TvfIlkcXS7IHHzd4F6 NVPWT5hHS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxNE4{PiEQvF2u NGDBO3g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwNVY1PCd-MkK4NFE3PDR:L3G+
HepG2 M2XFd2N6fG:2b4jpZ4l1gSCjc4PhfS=> M3XHZWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGwMlQ2KM7:TT6= NXPSXJZXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4NFE3PDRpPkKyPFAyPjR2PD;hQi=>
BGC823 MX\DfZRwfG:6aXPpeJkh[XO|YYm= Mk\YR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRmdEQDJ|IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG1MlY2KM7:TT6= M{DpcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OECxOlQ1Lz5{MkiwNVY1PDxxYU6=
Hep2 NIPYbFJEgXSxdH;4bYNqfHliYYPzZZk> M{SxemN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeDJiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkSuOVgh|ryPLh?= NXnZWGloRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4NFE3PDRpPkKyPFAyPjR2PD;hQi=>
MCF7 MUfDfZRwfG:6aXPpeJkh[XO|YYm= MW\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ2LkW4JO69VS5? MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjhyMU[0OEc,OjJ6MEG2OFQ9N2F-
A549 Ml7CR5l1d3SxeHnjbZR6KGG|c3H5 M4[1RmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{GuOVIh|ryPLh?= M3vyRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OECxOlQ1Lz5{MkiwNVY1PDxxYU6=
MDA231 MW\DfZRwfG:6aXPpeJkh[XO|YYm= M4fUOWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSTJ|MTDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzNU42PyEQvF2u M4i4RVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OECxOlQ1Lz5{MkiwNVY1PDxxYU6=
PC3 MmrWR5l1d3SxeHnjbZR6KGG|c3H5 MYjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOzVwN{Wg{txONg>? MmfyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6MEG2OFQoRjJ{OECxOlQ1RC:jPh?=
PC3M NUfpVGZ1S3m2b4TvfIlkcXS7IHHzd4F6 NVraXGdsPDhiaILz MWDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQR|NOKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyNk43OyEQvF2u MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjhyOUW1PEc,OjJ6MEm1OVg9N2F-
A549 NFnrSIhEgXSxdH;4bYNqfHliYYPzZZk> NUX6RlQ2PDhiaILz NXyxZmxbS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOzVwNEGg{txONg>? MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjhyOUW1PEc,OjJ6MEm1OVg9N2F-
MKN45 NH7QelREgXSxdH;4bYNqfHliYYPzZZk> NGfxTYk1QCCqcoO= NFjIeGZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOU052NTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPDFwN{Og{txONg>? MlW1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6MEm1OVgoRjJ{OEC5OVU5RC:jPh?=
HepG2 M1XCVmN6fG:2b4jpZ4l1gSCjc4PhfS=> NYTxWpBLPDhiaILz NUj3VHZZS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDR4LkizJO69VS5? MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjhyOUW1PEc,OjJ6MEm1OVg9N2F-
LoVo NYK1cIltSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NITTToo1QCCqcoO= NV\sOolbSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDMc3ZwKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzMlMh|ryPLh?= MkHhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6NEC0PVMoRjJ{OESwOFk{RC:jPh?=
A549 M2HuPWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MX60PEBpenN? MV7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF{Lkig{txONg>? NWqyVol7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4OFA1QTNpPkKyPFQxPDl|PD;hQi=>
MCF7 NEnpdoxCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M1PxbFQ5KGi{cx?= NHHSOoRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG2MlIh|ryPLh?= MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh2MES5N{c,OjJ6NEC0PVM9N2F-
IOSE-144 MUPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MWC0PEBpenN? MXvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEmRU1WtNVQ1KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyOU43KM7:TT6= MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh2MES5N{c,OjJ6NEC0PVM9N2F-
CAMA1 Ml3GR5l1d3SxeHnjbZR6KGG|c3H5 MX:3NkBpenN? MXHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDRW1COSClZXzsd{BqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCxMlI5KM7:TT6= NEXYV3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mki2O|cxPyd-MkK4Olc4ODd:L3G+
MCF7 NIrWU|lEgXSxdH;4bYNqfHliYYPzZZk> MlO2O|IhcHK| MkDRR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{BqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCzMlUh|ryPLh?= NH\kW3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mki2O|cxPyd-MkK4Olc4ODd:L3G+
HepG2 NHv1WI5EgXSxdH;4bYNqfHliYYPzZZk> M37q[|czKGi{cx?= Mo\RR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMhcW6ldXLheIVlKG[xcjC3NkBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gOU44KM7:TT6= MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh4N{ewO{c,OjJ6Nke3NFc9N2F-
FOCUS NH3POItEgXSxdH;4bYNqfHliYYPzZZk> MYO3NkBpenN? MmnWR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gSm9EXVNiY3XscJMhcW6ldXLheIVlKG[xcjC3NkBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gO{43QSEQvF2u M2LoNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OE[3O|A4Lz5{Mki2O|cxPzxxYU6=
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MNK45 M3HDfmN6fG:2b4jpZ4l1gSCjc4PhfS=> NED4cZg1QCCqcoO= MkXRR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUW5MPDViY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEzKM7:TT6= NWfVcVdWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwNFI6OjRpPkKzNFAzQTJ2PD;hQi=>
HepG2 NX6yVJF5SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NX31NJRwPDhiaILz M17qSGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBu\XSqb3SsJGlEPTBiPTCxMlMh|ryPLh?= Mlf5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyMUiwPVYoRjJ|MEG4NFk3RC:jPh?=
BGC823 M3rzUWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NFzqNWo1QCCqcoO= M4qwT2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQlfDPFI{KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQhdWW2aH;kMEBKSzVyIE2gNU42OiEQvF2u MoeyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyMUiwPVYoRjJ|MEG4NFk3RC:jPh?=
SW1116 MY\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MlXGOFghcHK| NInudIFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPXNVEyPiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKG2ndHjv[EwhUUN3MDC9JFIvPDFizszNMi=> NHnPb|U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CxPFA6Pid-MkOwNVgxQTZ:L3G+
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HT1080 MV;DfZRwfG:6aXPpeJkh[XO|YYm= NE[wNYc1QCCqcoO= Mli2R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHQyODhyIHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyPS5{IN88UU4> NFjR[FY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C2O|U1QSd-MkOwOlc2PDl:L3G+
HCT116 NFLQWpBEgXSxdH;4bYNqfHliYYPzZZk> M2DHb|Q5KGi{cx?= Mlz4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTF4IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{Pi52IN88UU4> NIjhO4U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C2O|U1QSd-MkOwOlc2PDl:L3G+
2008 M3;k[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWrHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjCyNFA5KGOnbHzzJIJ6KGO{eYP0ZYwhfmmxbHX0JIF{e2G7LDDJR|UxKD1iND6yJO69VS5? NH\rTHM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C3OVQyPCd-MkOwO|U1OTR:L3G+
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K562 MkTGR5l1d3SxeHnjbZR6KGG|c3H5 MlfxOFghcHK| NHzJTppEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzOy53NTFOwG0v NUHkXnpNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1OVgzOzhpPkKzOVU5OjN6PD;hQi=>
U937 M33RTmN6fG:2b4jpZ4l1gSCjc4PhfS=> MYi0PEBpenN? MXLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDVPVM4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyN{46OyEQvF2u MofiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3NUiyN|goRjJ|NUW4NlM5RC:jPh?=
HCT116 MXnDfZRwfG:6aXPpeJkh[XO|YYm= Moq3OFghcHK| MWjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFI4Njd4IN88UU4> NF\6cVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W1PFI{QCd-MkO1OVgzOzh:L3G+
HT1080 NYLHU4VyS3m2b4TvfIlkcXS7IHHzd4F6 M4fxdlQ5KGi{cx?= NXzJV25iS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUFRzMEiwJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB|NT62NkDPxE1w NVfONmRyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1OVgzOzhpPkKzOVU5OjN6PD;hQi=>
HepG2 MWLDfZRwfG:6aXPpeJkh[XO|YYm= NGfhO|M1QCCqcoO= NWnjcZNES3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDRyLkO0JO69VS5? NF35Oo89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W1PFI{QCd-MkO1OVgzOzh:L3G+
A549 NUTEOXg3S3m2b4TvfIlkcXS7IHHzd4F6 NISwOWc1QCCqcoO= NFi4b3pEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA1PC5yNTFOwG0v NIe0R2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W1PFI{QCd-MkO1OVgzOzh:L3G+
EC9706 MUXDfZRwfG:6aXPpeJkh[XO|YYm= NH7PWWQ4OiCqcoO= NWrFbo86S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTUN7N{C2JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkOyJO69VS5? MmX4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4NESxPVMoRjJ|NkS0NVk{RC:jPh?=
MGC803 NV7NcGxsS3m2b4TvfIlkcXS7IHHzd4F6 NF3pUng4OiCqcoO= MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNS2M5ODNiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFcvOTRizszNMi=> MnvFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4NESxPVMoRjJ|NkS0NVk{RC:jPh?=
MCF7 M4\3SWN6fG:2b4jpZ4l1gSCjc4PhfS=> MUK3NkBpenN? MUPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC3MlM{KM7:TT6= MnHCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4NESxPVMoRjJ|NkS0NVk{RC:jPh?=
SMMC7721 MUnDfZRwfG:6aXPpeJkh[XO|YYm= MVq3NkBpenN? NEPzcG9EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUVU2FN{eyNUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMk[uO|Eh|ryPLh?= MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ2NEG5N{c,OjN4NESxPVM9N2F-
HCT116 NXPn[3gzS3m2b4TvfIlkcXS7IHHzd4F6 NUDtPItIPDhiaILz MVPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgOFghcHK|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XluIFnDOVAhRSB2LkWyJO69VS5? NUPnfXJJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2OFQzOTVpPkKzOlQ1OjF3PD;hQi=>
HT-29 NGrsOpZEgXSxdH;4bYNqfHliYYPzZZk> NHGz[JQ1QCCqcoO= NIHMTYNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJXC1{OTDj[YxteyCjZoTldkA1QCCqcoOgZpkhe3WuZn;ybI9l[W2rbnWgRkBie3OjeTygTWM2OCB;IE[uN|Uh|ryPLh?= NYjneWdPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2OFQzOTVpPkKzOlQ1OjF3PD;hQi=>
A549 MkHkRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MlvaO|IhcHK| NYfj[XNwSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzMlUzKM7:TT6= MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ4NUGwOkc,OjN4NkWxNFY9N2F-
HCT116 NInqdFlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NHLwOZU4OiCqcoO= M4XJTmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC1MlU{KM7:TT6= NIrZb|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[2OVExPid-MkO2OlUyODZ:L3G+
HT-29 MXHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M{\wXVczKGi{cx?= NFm1dplCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjUMVI6KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyOE42KM7:TT6= M33IRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|Nk[1NVA3Lz5{M{[2OVExPjxxYU6=
MCF7 MUnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NVHVXIxOPzJiaILz NXjJS5BuSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzNk4yQCEQvF2u MorOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4NkWxNFYoRjJ|Nk[1NVA3RC:jPh?=
HeLa NGf3SWdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NI\WWIE4OiCqcoO= MYPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEinTHGgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDR|LkexJO69VS5? MkPRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4NkWxNFYoRjJ|Nk[1NVA3RC:jPh?=
colon cancer MWjDfZRwfG:6aXPpeJkh[XO|YYm= M1n5dlQ5KGi{cx?= NGLOSlFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBkd2yxbjDjZY5k\XJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JINwfWy2ZYKgZ492dnSncjDhcoFtgXOrczygS2k2OCB;IEiuOEDPxE1w Moe0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4OEO1PVIoRjJ|NkizOVkzRC:jPh?=
leukemia NWS3WGhLS3m2b4TvfIlkcXS7IHHzd4F6 NWiy[YRqPDhiaILz MWLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDs[ZVs\W2rYTDj[YxteyCjZoTldkA1QCCqcoOgZpkh[2:3bITldkBkd3WwdHXyJIFv[Wy7c3nzMEBIUTVyIE2gNVUvOSEQvF2u M3G0ZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkizOVkzLz5{M{[4N|U6OjxxYU6=
prostate cancer MkmyR5l1d3SxeHnjbZR6KGG|c3H5 MXO0PEBpenN? NEL4foZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBxem:|dHH0[UBk[W6lZYKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KGOxdXz0[ZIh[2:3boTldkBidmGueYPpd{whT0l3MDC9JFIzNjdizszNMi=> NIPNUY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[4N|U6Oid-MkO2PFM2QTJ:L3G+
renal cancer MWLDfZRwfG:6aXPpeJkh[XO|YYm= NVflfGRCPDhiaILz MojrR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gdoVv[WxiY3HuZ4VzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDjc5VtfGW{IHPveY51\XJiYX7hcJl{cXNuIFfJOVAhRSB2NT62JO69VS5? MmnUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4OEO1PVIoRjJ|NkizOVkzRC:jPh?=
SH-SY5Y MUTDfZRwfG:6aXPpeJkh[XO|YYm= NXXXfWJoPzJiaILz NVzsNol2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0hvU2m1XUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD65O{DPxE1w NFWxWWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[4OVU4OSd-MkO2PFU2PzF:L3G+
HCT116 Mk\XR5l1d3SxeHnjbZR6KGG|c3H5 M{nIS|czKGi{cx?= M1XlfmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOy5{NDFOwG0v Mnr5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4OEW1O|EoRjJ|Nki1OVcyRC:jPh?=
A549 MnmyR5l1d3SxeHnjbZR6KGG|c3H5 NF\3WWE4OiCqcoO= M2mzbWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFgvPzFizszNMi=> MkDwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4OEW1O|EoRjJ|Nki1OVcyRC:jPh?=
Vero M4fvU2N6fG:2b4jpZ4l1gSCjc4PhfS=> NWizcmZqPzJiaILz Ml;lR5l1d3SxeHnjbZR6KGGpYXnud5QhSW[{aXPhckBoemWnbjDtc45s\XliVnXyc{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iOT63NUDPxE1w Mk\hQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4OEW1O|EoRjJ|Nki1OVcyRC:jPh?=
MCF7 NGfjc|FEgXSxdH;4bYNqfHliYYPzZZk> MYC3NkBpenN? MkjvR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVAvOTRizszNMi=> NEXDNGE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[4OVU4OSd-MkO2PFU2PzF:L3G+
HepG2 MVfDfZRwfG:6aXPpeJkh[XO|YYm= MlvOO|IhcHK| NYXRV5k5S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ2Lkm2JO69VS5? MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ6NUW3NUc,OjN4OEW1O|E9N2F-
PC3 NUW3T4t6SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NV33eG1vPzJiaILz M321NGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFOzJINmdGy|IHX4dJJme3OrbnegV2tROiCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjdwMEeg{txONg>? NES5c3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{ezOVI5OSd-MkO3N|UzQDF:L3G+
PC3 NFvndGZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= Mlq4O|IhcHK| M33zeGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFOzJINmdGy|IHX4dJJme3OrbnegVGNFVkFiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDNzLkS0JO69VS5? NYPle5RbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3N|UzQDFpPkKzO|M2OjhzPD;hQi=>
COLO320DM NXfkRoNiS3m2b4TvfIlkcXS7IHHzd4F6 MlrYOFghcHK| M33XZmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNQVE9|MkDEUUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMjFOwG0v MnH5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5OUKzOVIoRjJ|N{myN|UzRC:jPh?=
HeLa MV;DfZRwfG:6aXPpeJkh[XO|YYm= NYTqZ5drPzJiaILz MnvvR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN{41KM7:TT6= NX61e3lsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3PVI4PjNpPkKzO|kzPzZ|PD;hQi=>
MCF7 NHLr[|ZEgXSxdH;4bYNqfHliYYPzZZk> NITNe484OiCqcoO= NFLYSpREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{NjZizszNMi=> MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd7Mke2N{c,OjN5OUK3OlM9N2F-
SW480 NX63SHhXS3m2b4TvfIlkcXS7IHHzd4F6 NV\ZUWxtPzJiaILz NGjsWHdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUXzR6MDDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hQC5zIN88UU4> MnXWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5OUK3OlMoRjJ|N{myO|Y{RC:jPh?=
MDA-MB-435S NX:1eohIS3m2b4TvfIlkcXS7IHHzd4F6 MY[3NkBpenN? NXjKflV[S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVQ{PVNiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE1NjVizszNMi=> NYnUVIxURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3PVI4PjNpPkKzO|kzPzZ|PD;hQi=>
LM7 MlPPR5l1d3SxeHnjbZR6KGG|c3H5 NUe2NIZFPzJiaILz