Fluorouracil (5-Fluorouracil, 5-FU)

For research use only. Not for use in humans.

製品コードS1209 別名:NSC 19893

Fluorouracil (5-Fluorouracil, 5-FU)化学構造

CAS No. 51-21-8

Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.

サイズ 価格(税別)  
10mM (1mL in DMSO) JPY 24200
JPY 26400
JPY 38500
最寄りの販売代理店を探す

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バルク問合せ

文献中Selleckの製品使用例(122)

製品安全説明書

DNA/RNA Synthesis阻害剤の選択性比較

生物活性

製品説明 Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.
ターゲット
Thymidylate synthase [1]
(Tumor cells)
体外試験

Adrucil is an analogue of uracil with a fluorine atom at the C-5 position in place of hydrogen. It rapidly enters the cell using the same facilitated transport mechanism as uracil. Adrucil is converted intracellularly to several active metabolites: fluorodeoxyuridine monophosphate (FdUMP), fluorodeoxyuridine triphosphate (FdUTP) and fluorouridine triphosphate (FUTP). The Adrucil metabolite FdUMP binds to the nucleotide-binding site of TS, forming a stable ternary complex with the enzyme and CH2THF, thereby blocking binding of the normal substrate dUMP and inhibiting dTMP synthesis. Metabolite of Adrucil also can be misincorporated into DNA, leading to DNA strand breaks and cell death. The pro-apoptosis effects of Adrucil may be related to its activation of tumor suppressor p53. Loss of p53 function reduces cellular sensitivity to Adrucil. [1] Adrucil is able to inhibit the survival and induce apoptosis of a board range of cancer cells. Adrucil suppresses viabilities of the nasopharyngeal carcinoma cell line CNE2 and HONE1 [2], pancreatic cancer cell lines Capan-1 [3], and human colon carcinoma cell line HT-29 [4] with IC50 of 9 μg/mL, 3 μg/mL, 0.22 μM, 2.5 μM, respectively.

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H292 NEXPWo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzEO|LDqGkEoB?= NXm5R3NOUUN3ME6gNlUh|rypL33M NGHHO2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC5OVE4Pid-MkSwPVUyPzZ:L3G+
HL-60 MoL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUK3NuKhcMLi MnvkTWM2OD16Lk[wNUDPxGdxbVy= NYPTW4VDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwPVUyPzZpPkK0NFk2OTd4PD;hQi=>
HT-29 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4CzUlczyqCqwrC= MonuTWM2OD5iMkWg{txoN22O NFvM[5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC5OVE4Pid-MkSwPVUyPzZ:L3G+
MCF-7 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDhRpM4PzMEoHlCpC=> MYPJR|UxRTJyIN88[{9uVA>? NHuxZlU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC5OVE4Pid-MkSwPVUyPzZ:L3G+
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MDA-MB-435S M{jycmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MXq3NkBpenN? NFvyV5FCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi12M{XTJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgcYV1cG:mLDDJR|UxKD1iMUSuOUDPxE1w NH7tfnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{WyOFY2PSd-MUe1NlQ3PTV:L3G+
HCCLM7 Mlm1RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MVy3NkBpenN? MU\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFQ1zNO{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJI1mfGixZDygTWM2OCB;IEG4MlYh|ryPLh?= NYrkWY5mRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1NlQ3PTVpPkG3OVI1PjV3PD;hQi=>
Caco-2 MXrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3PSOWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGNi[29vMjDj[YxteyxiSVO1NEA:KDFwNTFOwG0v M{jSWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUS4NVI6Lz5zN{W0PFEzQTxxYU6=
MCF7 NXrpfXo6SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MU[3NkBpenN? M4mwNWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB5MjDodpMtKEmFNUCgQUAxNjNizszNMi=> MlzSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NEixPVgoRjF5NUS4NVk5RC:jPh?=
HCT116 MnL3RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MW[3NkBpenN? MVrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDh[pRmeiB5MjDodpMtKEmFNUCgQUAzNjhizszNMi=> MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV2OEG5PEc,OTd3NEixPVg9N2F-
SW480 MYDBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NWXaOoZ3PzJiaILz M37qZWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU2e0PFAh[2WubIOgZYZ1\XJiN{KgbJJ{NCCLQ{WwJF0hOy53IN88UU4> NXzTeo1yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OFgyQThpPkG3OVQ5OTl6PD;hQi=>
SW48 NF;WVJJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NFHFTFU4OiCqcoO= NVnHWFNzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTW|Q5KGOnbHzzJIFnfGW{IEeyJIhzeyxiSVO1NEA:KDVwMzFOwG0v NH:0b2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W0PFE6QCd-MUe1OFgyQTh:L3G+
DLD1 Mlu5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3T5S2dzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGRNTDFiY3XscJMtKEmFNUCgQUA1NjVizszNMi=> NHG0W5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W1N|Y5PSd-MUe1OVM3QDV:L3G+
Caco-2 M17wc2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIfnU|YyOCCmYYnz MVrHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDDZYNwNTJiY3XscJMh[W[2ZYKgNVAh\GG7czygTWM2OCB;IEGuOUDPxE1w NWDHbm5LRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OVU6PjlpPkG3OVU2QTZ7PD;hQi=>
colon cancer cell NYfDepZYS3m2b4TvfIlkcXS7IHHzd4F6 MnvCR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gZ49td25iY3HuZ4VzKGOnbHzzMEBIUTVyIE2gOU44PSEQvF2u NYjWXYtkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OlI{PjVpPkG3OVYzOzZ3PD;hQi=>
A549 NHTxR21EgXSxdH;4bYNqfHliYYPzZZk> NX\BZXRRPDhiaILz NH7GXW9EgXSxdH;4bYNqfHliYXfhbY5{fCCDNUS5JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB7LkKg{txONg>? MmDUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4MESzPVQoRjF5NkC0N|k1RC:jPh?=
L1210 NFTVZ4xEgXSxc4TheIlkKGGldHn2bZR6KGG|c3H5 M1XyfGN6fG:|dHH0bYMh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDMNVIyOCClZXzsd{whUUN3MDC9JFAvOjhizszNMi=> NH35[og9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{mzNVg3Oid-MUe5N|E5PjJ:L3G+
CEM NWTNcJBJS3m2b4P0ZZRq[yCjY4Tpeol1gSCjc4PhfS=> NFG0[HREgXSxc4TheIlkKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gR2VOKGOnbHzzMEBKSzVyIE2gPUDPxE1w NWfwSnlQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5N|E5PjJpPkG3PVMyQDZ{PD;hQi=>
Molt4/C8 MnOwR5l1d3O2YYTpZ{Bi[3Srdnn0fUBie3OjeR?= MUXDfZRwe3SjdHnjJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTX;seFQwSzhiY3XscJMtKEmFNUCgQUAzOyEQvF2u MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzl|MUi2Nkc,OTd7M{G4OlI9N2F-
Caco-2 NUHReGRsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUGxNEBl[Xm| M13DSmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGNi[29vMjDj[YxteyCjZoTldkAyOCCmYYnzMEBKSzVyIE2gNU42KM7:TT6= M2\OOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6MEO3NVk2Lz5zOECzO|E6PTxxYU6=
MCF7 MofjRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MUWzJIRigXN? NF\OVWhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiMzDkZZl{KGK7IGPSRkBie3OjeTygTWM2OCB;IESuN|Ih|ryPLh?= MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDB4OUC5N{c,OThyNkmwPVM9N2F-
MCF7 MkXIRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MYTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNuIFnDOVAhRSB2LkOyJO69VS5? NWPoe4ljRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUixPVQ5PjZpPkG4NVk1QDZ4PD;hQi=>
embryonic cell MWPGeY5kfGmxbjDhd5NigQ>? NWnYRmJYUW6mdXP0bY9vKG:oIHPs[YF3[WenIHHydoV{fCCrbjDlcYJzgW:waXOgZ4VtdHNib3[gd5Ri\2ViODDY[Y5weHW|IHzh[ZZqeyCkbHHzeJVt[WVuIFnDOVAhRSB{Nj64JO69VS5? M2rzVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6MkexOVU5Lz5zOEK3NVU2QDxxYU6=
HepG2 NVXRXmtnS3m2b4TvfIlkcXS7IHHzd4F6 MnfHR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMtKEmFNUCgQUAyQC55IN88UU4> NGrobZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEOwNlM{Pid-MUizNFI{OzZ:L3G+
L1210 NVnqWWRqSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= Ml7sNkBl[Xm| NHfBTJNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFyxNlExKGOnbHzzJIFnfGW{IEKg[IF6eyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlY6KM7:TT6= M4PXVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NEK0NVU2Lz5zOESyOFE2PTxxYU6=
MCF7 M4r0T2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 M1zTRVMh\GG7cx?= M{myN2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB|IHThfZMh[nliTWTUJIF{e2G7LDDJR|UxKD1iND61JO69VS5? NX3BXo9DRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0NlQyPTVpPkG4OFI1OTV3PD;hQi=>
MiaPaCa2 NXTueVJoSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NXvSfFhUOyCmYYnz NV;STXExSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNbYFR[UOjMjDj[YxteyCjZoTldkA{KGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPi53IN88UU4> NVvHWVFyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0NlQyPTVpPkG4OFI1OTV3PD;hQi=>
SW620 M37k[mFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MlmwN{Bl[Xm| NIDSTFZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPXOlIxKGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC4Mlch|ryPLh?= MlrSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2MkSxOVUoRjF6NEK0NVU2RC:jPh?=
HepG2 MWnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? Mk\CN{Bl[Xm| MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEincFeyJINmdGy|IHHmeIVzKDNiZHH5d{BjgSCPVGSgZZN{[XluIFnDOVAhRSB7LkKg{txONg>? NVXDVmhrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0NlQyPTVpPkG4OFI1OTV3PD;hQi=>
CEM MmjIRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NW\aRZUxOyCmYYnz M3vz[GFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQ1XNJINmdGy|IHHmeIVzKDNiZHH5d{BjgSCPVGSgZZN{[XluIFnDOVAhRSB7LkKzJO69VS5? NEC2cm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOESyOFE2PSd-MUi0NlQyPTV:L3G+
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HeLa MVHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MUezJIRigXN? NFzTXlhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjlUIEh[2WubIOgZYZ1\XJiMzDkZZl{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG2JO69VS5? Ml3UQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2MkSxOVUoRjF6NEK0NVU2RC:jPh?=
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A549 MXfDfZRwfG:6aXPpeJkh[XO|YYm= NH25Xm44OiCqcoO= NUTEbGl3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hQS5zOTFOwG0v NVHH[3ZWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0OFAzOzNpPkG4OFQxOjN|PD;hQi=>
HT1080 M4X3OWN6fG:2b4jpZ4l1gSCjc4PhfS=> NVzG[WxTPzJiaILz MV7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIWFExQDBiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFkvPDVizszNMi=> NVK3cJg4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0OFAzOzNpPkG4OFQxOjN|PD;hQi=>
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COLO205 MVzBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NUfhRW9iPzJiaILz Mo\iRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDwOVMh\GWoaXPp[Y51KGi3bXHuJGNQVE9{MEWgZ4VtdHNiYX\0[ZIhPzJiaILzMEBKSzVyIE2gNVEvPjNizszNMi=> MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDR4OUiwPUc,OTh2Nkm4NFk9N2F-
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HCT15 NGrzPWdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MofQO|IhcHK| NVjPWHpnSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyPSClZXzsd{BmgHC{ZYPzbY5oKHB3MzDn[Y5mKGGodHXyJFczKGi{czDifUBxem:uaX\ldoF1cX[nIHHzd4F6NCCLQ{WwJF0hOThwMkSg{txONg>? MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDR4OUiwPUc,OTh2Nkm4NFk9N2F-
SW480 NYO4R2RjSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MnGyO|IhcHK| MmDkRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDwOVMh\GWoaXPp[Y51KGi3bXHuJHNYPDhyIHPlcIx{KGGodHXyJFczKGi{czDifUBxem:uaX\ldoF1cX[nIHHzd4F6NCCLQ{WwJF0hOjZwMk[g{txONg>? NVHXT2NQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0Olk5ODlpPkG4OFY6QDB7PD;hQi=>
MCF7 NVX5NmdTSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NXvJ[GJrPzJiaILz NWHtfm03SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIV5eHKnc4PpcocheDV|IHflcoUh[W[2ZYKgO|IhcHK|IHL5JJBzd2yrZnXyZZRqfmViYYPzZZktKEmFNUCgQUAzPi54NzFOwG0v NWPORodMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0Olk5ODlpPkG4OFY6QDB7PD;hQi=>
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Hep3B M13CdGN6fG:2b4jpZ4l1gSCjc4PhfS=> M1Hz[WN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeDOEIHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuOkDPxE1w MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDZyNkW0Okc,OTh4ME[1OFY9N2F-
MCF7 M3nZd2N6fG:2b4jpZ4l1gSCjc4PhfS=> NVLyZ5R1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxMlUh|ryPLh?= NXf2S21yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi2NFY2PDZpPkG4OlA3PTR4PD;hQi=>
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HaCaT NIrlc5hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFTIWVE4OiCqcoO= NYqwXWpVT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUGGFYWSgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwNDFOwG0v MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDZ2MEe0Okc,OTh4NEC3OFY9N2F-
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SW620 NE\RSJRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4X5ZlczKGi{cx?= NY\4bmdqT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hW1d4MkCgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDlizszNMi=> M4PVOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NkSwO|Q3Lz5zOE[0NFc1PjxxYU6=
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MCF7 MmC3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MU[3NkBpenN? NHHmVIZIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyPSEQvF2u M33DNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NkSwO|Q3Lz5zOE[0NFc1PjxxYU6=
B16 NGn4Zm5EgXSxdH;4bYNqfHliYYPzZZk> NHfW[JBEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBDOTZiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iOD63N{DPxE1w MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDZ2NEexPEc,OTh4NES3NVg9N2F-
A549 MnL0R5l1d3SxeHnjbZR6KGG|c3H5 NGC2OJJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGwMlg2KM7:TT6= MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDZ2NEexPEc,OTh4NES3NVg9N2F-
SW480 MmfFR5l1d3SxeHnjbZR6KGG|c3H5 NEjsVYdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUXzR6MDDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxN{4yPiEQvF2u MkTpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh4NES3NVgoRjF6NkS0O|E5RC:jPh?=
BEL-7402 Mo\ZR5l1d3SxeHnjbZR6KGG|c3H5 Mk\CR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRmVNNTd2MEKgZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVQvPDFizszNMi=> MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDZ2NEexPEc,OTh4NES3NVg9N2F-
BGC-7901 M3LIWGN6fG:2b4jpZ4l1gSCjc4PhfS=> NH3xWmREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBDT0NvN{mwNUBk\WyuczDifUBOXFRiYYPzZZktKEmFNUCgQUAyPi5|NTFOwG0v Mo\MQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh4NES3NVgoRjF6NkS0O|E5RC:jPh?=
HL60 NEHsS2NEgXSxdH;4bYNqfHliYYPzZZk> M4LsWWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhNPjBiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkGuN|gh|ryPLh?= MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDZ2NEexPEc,OTh4NES3NVg9N2F-
3T3 M1TUOWN6fG:2b4jpZ4l1gSCjc4PhfS=> M4DKW|Q5KGi{cx?= NEO2XXFEgXSxdH;4bYNqfHliYXfhbY5{fCCEQVzCJI1wfXOnIEPUN{Bk\WyuczDh[pRmeiB2ODDodpMtKEeLNUCgQUAyNjV2IN88UU4> NUWyelhqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi3PVg3ODlpPkG4O|k5PjB7PD;hQi=>
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MCF7 NGfieoREgXSxdH;4bYNqfHliYYPzZZk> M1jCWlQ5KGi{cx?= MkHKR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC0PEBpenNuIFfJOVAhRSB4LkWg{txONg>? NWT4RpFpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi3PVg3ODlpPkG4O|k5PjB7PD;hQi=>
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K562 M4DWOGN6fG:2b4jpZ4l1gSCjc4PhfS=> NEm0Tm01QCCqcoO= NV3ldotoS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkA1QCCqcoOsJGdKPTBiPTCxOk44KM7:TT6= NFL2UXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEe5PFYxQSd-MUi3PVg3ODl:L3G+
M14 M{HIcmN6fG:2b4jpZ4l1gSCjc4PhfS=> NULVTJRwPDhiaILz NF\LU41EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOOTRiY3XscJMh[W[2ZYKgOFghcHK|LDDHTVUxKD1iMkKuOEDPxE1w NHfMWIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEe5PFYxQSd-MUi3PVg3ODl:L3G+
colon cancer cell MoTUS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3HNVlQ5KGi{cx?= NHPsPWFIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBEd2yxbjDjZY5k\XJiY3XscJMh[W[2ZYKgOFghcHK|LDDHTVUxKD1iOD6zO{DPxE1w NXH6T4JnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi5OVA6ODRpPkG4PVUxQTB2PD;hQi=>
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Colo-357 M{LsZ2N6fG:2b4jpZ4l1gSCjc4PhfS=> MYHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDc4xwNTN3NzDj[YxteyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yxiSVO1NEA:KDJwMEWg{txONg>? NXK5OW1mRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC5N|AyOjNpPkKwPVMxOTJ|PD;hQi=>
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Hep2 NH:0U|hCdnSrY3HuZ4VzKGG|c3H5 NVOyOoMzPDhiaILz Mon4RY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldFIh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygTWM2OCB;IECuN{DPxE1w Ml72QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyN{S0OFQoRjJzMEe0OFQ1RC:jPh?=
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DU145 MYLBcpRq[2GwY3XyJIF{e2G7 MXy0PEBpenN? NFm3[JNCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gSHUyPDViY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFQvQCEQvF2u MoXNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyN{S0OFQoRjJzMEe0OFQ1RC:jPh?=
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colon cancer cell M1n1dGN6fG:2b4jpZ4l1gSCjc4PhfS=> MXW0PEBpenN? MoD6R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gZ49td25iY3HuZ4VzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDjc5VtfGW{IHPveY51cW6pLDDHTVUxKD1iOD60JO69VS5? NXnuepZrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwOVYzPzdpPkKyNFU3Ojd5PD;hQi=>
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colon cancer cell NUftTWc1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MorMOFghcHK| NF7lVZZIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBkd2yxbjDjZY5k\XJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JINwfWy2ZYKgZ492dnSncjDt[ZRpd2RuIFfJOVAhRSB6LkSg{txONg>? MofRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzMUmxOVEoRjJ{MUG5NVUyRC:jPh?=
leukemia cell M{nTbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{PSc|Q5KGi{cx?= NU[1enNmT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hdGW3a3XtbYEh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IHPveYx1\XJiY3;1cpRmeiCvZYToc4QtKEeLNUCgQUAyPS5zIN88UU4> MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjFzOUG1NUc,OjJzMUmxOVE9N2F-
prostate cancer cell M1PWd2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2TnOFQ5KGi{cx?= MWTHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDwdo9{fGG2ZTDjZY5k\XJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JINwfWy2ZYKgZ492dnSncjDt[ZRpd2RuIFfJOVAhRSB{Mj63JO69VS5? NXjrNINFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxNVkyPTFpPkKyNVE6OTVzPD;hQi=>
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HepG2 MoW2R5l1d3SxeHnjbZR6KGG|c3H5 MVS3NkBpenN? MWTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|IvOjJizszNMi=> NVjlXnFERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2PFc4PDVpPkKyOlg4PzR3PD;hQi=>
NCI-H460 NH\p[mpEgXSxdH;4bYNqfHliYYPzZZk> M37Rb|czKGi{cx?= NFf1cI5EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvSES2NEBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMj60JO69VS5? M1nOSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{K3OFQ2Lz5{MkeyO|Q1PTxxYU6=
BGC823 MVLDfZRwfG:6aXPpeJkh[XO|YYm= M1L3bVczKGi{cx?= M4HycGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJISzh{MzDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPC53IN88UU4> M2fGelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{K3OFQ2Lz5{MkeyO|Q1PTxxYU6=
HepG2 MnXoR5l1d3SxeHnjbZR6KGG|c3H5 MWS3NkBpenN? Mn\OR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFQvQCEQvF2u MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjd{N{S0OUc,OjJ5Mke0OFU9N2F-
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MCF7 MUTDfZRwfG:6aXPpeJkh[XO|YYm= NXLHO2c3PzJiaILz NFOx[XJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyOi53IN88UU4> MnvpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5Mke0OFUoRjJ{N{K3OFQ2RC:jPh?=
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MCF7 MnXnR5l1d3SxeHnjbZR6KGG|c3H5 NVu5eWZOPzJiaILz M3XjNmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE1NjJizszNMi=> NECyZYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mke0PVE6Oid-MkK3OFkyQTJ:L3G+
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MGC803 NVPUXlhMS3m2b4TvfIlkcXS7IHHzd4F6 MlO0O|IhcHK| NULae|U5S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUeFOECzJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzOD61JO69VS5? Ml7OQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5NEmxPVIoRjJ{N{S5NVkzRC:jPh?=
MCF7 MkjYRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MYW3NkBpenN? M33GN2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB5MjDodpMh[nliY4L5d5RidCC4aX;s[ZQhe3SjaX7pcochdWW2aH;kMEBKSzVyIE2gOE44KM7:TT6= MmLOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5NkW4PVcoRjJ{N{[1PFk4RC:jPh?=
HT-29 MV3BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NYnyc2N6PzJiaILz M4fTSWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSGStNlkh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IHPyfZN1[WxidnnvcIV1KHO2YXnubY5oKG2ndHjv[EwhUUN3MDC9JFcvOyEQvF2u NHHCbGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mke2OVg6Pyd-MkK3OlU5QTd:L3G+
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HT1080 NGfKc3REgXSxdH;4bYNqfHliYYPzZZk> NGjNWpJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJXDFyOECgZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN{4xPiEQvF2u M{D4ZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OECxOlQ1Lz5{MkiwNVY1PDxxYU6=
A375-S2 NFHFbGFEgXSxdH;4bYNqfHliYYPzZZk> NV\PTpVZS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTN5NT3TNkBk\WyuczDifUBOXFRiYYPzZZktKEmFNUCgQUA6Njl{IN88UU4> NEHic2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwNVY1PCd-MkK4NFE3PDR:L3G+
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HepG2 MV7DfZRwfG:6aXPpeJkh[XO|YYm= NEfQUGpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxNE41PSEQvF2u NF3IOY49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwNVY1PCd-MkK4NFE3PDR:L3G+
BGC823 NUWwW2pkS3m2b4TvfIlkcXS7IHHzd4F6 Mn7LR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRmdEQDJ|IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG1MlY2KM7:TT6= NY\HTGJERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4NFE3PDRpPkKyPFAyPjR2PD;hQi=>
Hep2 NUH3TJF[S3m2b4TvfIlkcXS7IHHzd4F6 NEH2S|REgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XB{IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEK0MlU5KM7:TT6= NHfKWZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwNVY1PCd-MkK4NFE3PDR:L3G+
MCF7 MlHlR5l1d3SxeHnjbZR6KGG|c3H5 NVvHWHJjS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyOE42QCEQvF2u NFvhc|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwNVY1PCd-MkK4NFE3PDR:L3G+
A549 NX60[IMxS3m2b4TvfIlkcXS7IHHzd4F6 MmnxR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB|MT61NkDPxE1w NHL6[ng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwNVY1PCd-MkK4NFE3PDR:L3G+
MDA231 NV\4N4dMS3m2b4TvfIlkcXS7IHHzd4F6 M2jsRWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSTJ|MTDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzNU42PyEQvF2u MkLZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6MEG2OFQoRjJ{OECxOlQ1RC:jPh?=
PC3 MlvnR5l1d3SxeHnjbZR6KGG|c3H5 NVLYT|FNS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEN|IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEO1Mlc2KM7:TT6= NEDy[YE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwNVY1PCd-MkK4NFE3PDR:L3G+
PC3M MU\DfZRwfG:6aXPpeJkh[XO|YYm= Ml;5OFghcHK| MX7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQR|NOKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyNk43OyEQvF2u MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjhyOUW1PEc,OjJ6MEm1OVg9N2F-
A549 M4L5OmN6fG:2b4jpZ4l1gSCjc4PhfS=> MUi0PEBpenN? MlPER5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|UvPDFizszNMi=> NF7kclI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwPVU2QCd-MkK4NFk2PTh:L3G+
MKN45 NGTmT25EgXSxdH;4bYNqfHliYYPzZZk> NIDCbnA1QCCqcoO= NFfXUpVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOU052NTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPDFwN{Og{txONg>? MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjhyOUW1PEc,OjJ6MEm1OVg9N2F-
HepG2 MWHDfZRwfG:6aXPpeJkh[XO|YYm= NU\mUIJlPDhiaILz NI\uOGdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPDZwOEOg{txONg>? M4[0OlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEC5OVU5Lz5{MkiwPVU2QDxxYU6=
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A549 MoHGRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NX25TGkyPDhiaILz MWrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF{Lkig{txONg>? NVTlWW9RRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4OFA1QTNpPkKyPFQxPDl|PD;hQi=>
MCF7 MlHHRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MVu0PEBpenN? MVXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF4LkKg{txONg>? NH;pdmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mki0NFQ6Oyd-MkK4OFA1QTN:L3G+
IOSE-144 Mn\ORY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MlvCOFghcHK| MoiyRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCLT2PFMVE1PCClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlUvPiEQvF2u NWG1PI9SRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4OFA1QTNpPkKyPFQxPDl|PD;hQi=>
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HuH7 NVezOmVJS3m2b4TvfIlkcXS7IHHzd4F6 MmTpO|IhcHK| NHLaXoNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJfUh5IHPlcIx{KGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFMxNjdizszNMi=> Ml;QQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6Nke3NFcoRjJ{OE[3O|A4RC:jPh?=
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leukemia NV74TYl7SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M4nEdFQ5KGi{cx?= MoWzRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCuZYXr[Y1q[SClZXzsd{Bi\nSncjC0PEBpenNiYomgZ4VtdCClb4XueIlv\yCjbnHsfZNqeyxiR1m1NEA:KDF3LkGg{txONg>? MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl7NU[yNUc,OjJ7OUW2NlE9N2F-
prostate cancer NITPWG9CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NEPtUJI1QCCqcoO= M{DvU2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5icILvd5RifGViY3HuZ4VzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDj[YxtKGOxdX70bY5oKGGwYXz5d4l{NCCJSUWwJF0hOjJwNzFOwG0v MkTqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7OUW2NlEoRjJ{OUm1OlIyRC:jPh?=
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HeLa Ml\VR5l1d3SxeHnjbZR6KGG|c3H5 MWm0PEBpenN? M1jwb2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmVGFiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFkvPSEQvF2u NFTyepo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CwNlkzPCd-MkOwNFI6OjR:L3G+
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SW1116 NUHadZJ6SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MVW0PEBpenN? NVeye21JSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTW|EyOTZiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCvZYToc4QtKEmFNUCgQUAzNjRzIN88UU4> MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzBzOEC5Okc,OjNyMUiwPVY9N2F-
HeLa Mm\5RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NULX[GlMPDhiaILz M3vBN2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXMZUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJI1mfGixZDygTWM2OCB;IEOuNlUh|ryPLh?= MoD6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyMUiwPVYoRjJ|MEG4NFk3RC:jPh?=
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HT1080 NXrhVpBxS3m2b4TvfIlkcXS7IHHzd4F6 MmWzOFghcHK| NWK0UphuS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUFRzMEiwJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzNT6yJO69VS5? NH71T|c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C2O|U1QSd-MkOwOlc2PDl:L3G+
HCT116 NWX3PXpRS3m2b4TvfIlkcXS7IHHzd4F6 MoXsOFghcHK| MX\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFM3NjRizszNMi=> MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB4N{W0PUc,OjNyNke1OFk9N2F-
2008 M3:3cGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWXHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjCyNFA5KGOnbHzzJIJ6KGO{eYP0ZYwhfmmxbHX0JIF{e2G7LDDJR|UxKD1iND6yJO69VS5? NYrwbJVwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwO|U1OTRpPkKzNFc2PDF2PD;hQi=>
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C13 M1z0WWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmfmS5Jwf3SqIHnubIljcXSrb36gc4Yh[0SGUD3y[ZNqe3SjboSgbJVu[W5iQ{GzJINmdGy|IHL5JINzgXO2YXygeolwdGW2IHHzd4F6NCCLQ{WwJF0hQC53IN88UU4> Ml7vQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyN{W0NVQoRjJ|MEe1OFE1RC:jPh?=
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HCT116 Mly1R5l1d3SxeHnjbZR6KGG|c3H5 NYrTTWRmPDhiaILz M1\tWGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjdwN{[g{txONg>? MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV3OEKzPEc,OjN3NUiyN|g9N2F-
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HepG2 M4nPXGN6fG:2b4jpZ4l1gSCjc4PhfS=> MX60PEBpenN? NFvSZo5EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPDBwM{Sg{txONg>? NVW5c3JMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1OVgzOzhpPkKzOVU5OjN6PD;hQi=>
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EC9706 M2HvcWN6fG:2b4jpZ4l1gSCjc4PhfS=> NIfoTmY4OiCqcoO= M1jHR2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGVEQTdyNjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5|MjFOwG0v MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ2NEG5N{c,OjN4NESxPVM9N2F-
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leukemia NYf2OZFMS3m2b4TvfIlkcXS7IHHzd4F6 NX64VWM{PDhiaILz Mm[4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gcIV2c2WvaXGgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KGOxdXz0[ZIh[2:3boTldkBidmGueYPpd{whT0l3MDC9JFE2NjFizszNMi=> NGjaW2Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[4N|U6Oid-MkO2PFM2QTJ:L3G+
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renal cancer MUXDfZRwfG:6aXPpeJkh[XO|YYm= M2ni[|Q5KGi{cx?= NVf0dINDS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hemWwYXygZ4Fv[2W{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBkd3WudHXyJINwfW62ZYKgZY5idHm|aYOsJGdKPTBiPTC0OU43KM7:TT6= M1fTTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkizOVkzLz5{M{[4N|U6OjxxYU6=
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A549 MV3DfZRwfG:6aXPpeJkh[XO|YYm= NHvKdlc4OiCqcoO= M1q3b2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFgvPzFizszNMi=> NVj4W49NRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2PFU2PzFpPkKzOlg2PTdzPD;hQi=>
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PC3 M122cmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M13hVlczKGi{cx?= NWHxU4dWSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOg[ZhxemW|c3nu[{BUU1B{IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{Nz6wO{DPxE1w NVfZWmNNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3N|UzQDFpPkKzO|M2OjhzPD;hQi=>
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