Doxorubicin (Adriamycin) HCl

Licensed by Pfizer 製品コードS1208 別名:NSC 123127

Doxorubicin (Adriamycin) HCl化学構造

分子量(MW):579.98

Doxorubicin (Adriamycin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.

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JPY 19422.00
JPY 14940.00
JPY 34860.00
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文献中Selleckの製品使用例(33)

カスタマーフィードバック(9)

  • Enhancement of apoptotic response by addition of targeted agents lapatinib and sunitinib to doxorubicin in the same device reservoir at 24 hours. P values were determined using Student’s t test for all graphs.

    Sci Transl Med, 2015, 7(284): 284ra57 . Doxorubicin (Adriamycin) HCl purchased from Selleck.

    (F) Kaplan-Meier curves are shown for all groups described: no hydrogel, a hydrogel loaded with paclitaxel, or a hydrogel loaded with doxorubicin. The number of mice per group (n) and median survival (ms) are listed. The experiment was performed at least three times.

    Science, 2018, 10(433), doi: 10.1126/scitranslmed.aar1916. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • Cell viabilities with increasing concentrations of cisplatin (CP) and doxorubicin (DOXO) under normoxic and hypoxic condition for 48 hours were determined by MTT assay. IC50 values are presented as the means ?SDs (n=4) and * denotes p<0.05.

    Cancer Res 2014 74, 298-308. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    Cleavage of caspase-3, -9 and the expression of PARP were measured by western blot using b-actin as a loading control.

    Cell Cycle, 2017, 16(5):468-476. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • (C) & (D) Treatments with doxorubicin, cisplatin or AZD6244 further decreased the cell viability in RH30 cloned cells in which STAT3 or GP130 was knockdown by shRNA. (*P<.05, ** P <.01, *** P <.001).

    Curr Cancer Drug Targets, 2016, 16(7):631-8. Doxorubicin (Adriamycin) HCl purchased from Selleck.

     

    Doxorubicin release of P(MAA-g-EG) and P(MAA-g-EG) containing nanoparticles in two-step pH conditions. Doxorubicinloaded P(MAA-g-EG) ,P(MAA-g-EG)-1.0NP ,P(MAA-g-EG)-2.5NP, and P(MAA-g-EG)-5.0NP crushed particles (75–150 um) were released in 1 PBS (pH 2.0) for 90 min. Then the pH was increased to 7.0 by adding 5N NaOH and release continued for 6 h.

    J Biomed Mater Res Part A 2012 10.1002/jbm.a.34064. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • Temporal uptake of free DOX or DOX-PCL63-b-PNVP90 micelles into K-562 (I) and DL (J) cells were studied by incubating in 24-well plates at a concentration of 50,000 cells per well. Representative images shown were obtained using a fluorescence microscope Eclipse 80i (Nikon, Japan) (Plan Fluor, 40X, NA 0.75 objective) equipped with blue and red filters for, Hoechst and Doxorubicin respectively (n = 3).

    PLoS One 2014 9, e94309. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    PLoS One 2013 8(1), e54595. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • CON+ -positive control (with FBS as chemoattractant); CON- - negative control (without chemoattractant); DOX -doxorubicin; WZ -WZ811; PF- PF-573228; * -significant difference compared to positive control: p<0.05; ** -significant difference compared to positive control: p<0.01; # -significant difference between combination and inhibitor only: p<0.05. Cancer cell invasion was analyzed using Transwell membranes assembled in 24-well plates and covered with a layer of Matrigel. COR-L23 cells were treated for 24 h with 50 nM DOX, 10 uM WZ811, 5 uM PF-573228 and combinations of inhibitors with 50 nM DOX. Similarly, RH460 cells were treated for 24 h with 1 uM DOX, 10 uM WZ811, 2.5 uM PF-573228 and combinations of inhibitors with 1 uM DOX. Applied doses were the ones that exerted the most pronounced synergistic effect on cytotoxicity level. After the incubation period, cells that invaded through matrigel and membranes were fixed in 4% paraformaldehyde-PBS and stained with Hoechst 33342 nuclear stain. Cells were visualized and counted under a fluorescent microscope at 10x magnification.

    2014 Dr Milica Pesic from Institute for Biological Research. Doxorubicin (Adriamycin) HCl purchased from Selleck.

製品安全説明書

Topoisomerase阻害剤の選択性比較

生物活性

製品説明 Doxorubicin (Adriamycin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.
ターゲット
Topo II [1]
(Tumor cells)
体外試験

Doxorubicin, an antibiotic anthracycline, is commonly considered to exert its anti-tumor activity at two fundamental levels, altering DNA and producing free radicals to trigger apoptosis of cancer cells through DNA damage. Doxorubicin can block the synthesis of DNA by intercalating into the DNA strand, and inhibits DNA topoisomerase II (TOP2). Doxorubicin is most effective when cells are rapidly proliferating and expressing high levels of TOP2. Additionally, Doxorubicin can trigger apoptosis by producing ceramide (which prompts apoptosis by activating p53 or other downstream pathways such as JNK), the degradation of Akt by serine threonine proteases, the mitochondrial release of cytochrome c, increased FasL (death receptor Fas/CD95 ligand) mRNA production, and a greater production of free radicals. [2] Pre-treatment with GSNO (nitrosoglutathione) suppresses the resistance in the doxorubicin-resistant breast cancer cell line MCF7/Dx, accompanied by enhanced protein glutathionylation and accumulation of doxorubicin in the nucleus. [3] Doxorubicin induced G2/M checkpoint arrest are attributed to elevated cyclin G2 (CycG2) expression and phospho-modification of proteins in the ataxia telangiectasia mutated (ATM) and ATM and Rad3-related (ATR) signaling pathways. [5] Doxorubicin inhibits AMP-activated protein kinase (AMPK), resulting in SIRT1 dysfunction, p53 accumulation, and increased cell death in mouse embryonic fibroblasts (MEFs) and cardiomyocytes, which can be further sensitized by pre-inhibition of AMPK. [6] Doxorubicin elicits a marked heat shock response, and that either inhibition or silencing of heat shock proteins enhance the Doxorubicin apoptotic effect in neuroblastoma cells. Nanomolar Doxorubicin treatment of neuroblastoma cells causes dose-dependent over-ubiquitination of a specific set of proteins in the absence of measurable inhibition of proteasome, and loss of activity of ubiquitinated enzymes such as lactate dehydrogenase and α-enolase, the protein ubiquination patterns of which is similar to those with proteasome inhibitor Bortezomib, indicating that Doxorubicin may also exert its effect by damaging proteins. [8]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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CHO NIDZOZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwME[g{txO NIDkWGUyOzV2N{Ww
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T-C8166 MnzaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHyemNKTDVyPUCuNFEh|ryP M{PwOVE2PDh4OEG=
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T-MT4 NFuydYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3LTWQ2OD1yLkCxJO69VQ>? MoPDNVU1QDZ6MR?=
SKMEL-5 NYCxWVJzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mki2SWQ2OD1|LkKg{txO MYCxOlE{PzV|
MLM NI\HUpREgXSxdH;4bYMhSXO|YYm= MV7FSFUxRTBwMUOg{txO M3;jNlE5PzV|NUC=
KBM-3 MljQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWThbmh7UUN3ME2wMlAzPiEQvF2= NFexOIwyQTl3OEe3
HT-29 M2\zOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\zd4QxNjBzIN88[y=> MWO0PEBp NV\aZ3BDSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJk> MYWyO|c5PDR7
EMT6 Mom1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUKwMlUh|ryP MmK1NUBp MVjJcohq[mm2aX;uJI9nKHC{b3zp[oVz[XSrb36gZpkhdWWjc4XybY5oKG[xcjDzeZJ3cX[rbneg[pJi[3Srb37zJJdqfGhiRVS1NEBw\iByLkCwNFEh|ryP NGrIdGc4PDV{Nke0
H2981 NUPOVHpZS3m2b4TvfIlkKEG|c3H5 MnOxTWM2OD1yLkWg{txO M1S2[Fc4OzFyMkO=
LOX NWrL[2liS3m2b4TvfIlkKEG|c3H5 NXjkbpN3UUN3ME2wMlA1OiEQvF2= MoTKO|g2OzN|MR?=
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MCF MUXGeY5kfGmxbjDBd5NigQ>? MlvBVoV3\XK|YXygc4YhWC2pcD3t[YRq[XSnZDDteYx1cWS{dXegdoV{cXO2YX7j[UBie3Onc4Pl[EBieyCnbnjhcoNmdWWwdDDpckBkgXSxdH;4bYNqfHlib3[gZYRzcWGveXPpci=> MljkPFk5PDF3MR?=
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C6 M4HkWGZ2dmO2aX;uJGF{e2G7 NVrHSYRyOi53IH3nM41N M2\MdlQhcA>? MlTUSG1UVw>? M3q5WWlvcGmkaYTpc44hd2ZidIXieYxqdiCyb3z5cYVzcXqjdHnvci=> NVfMTnN6QDl6OE[wOC=>
C6 NVr1ZmkxS3m2b4TvfIlkKEG|c3H5 NF7UbHUzNjVibXevcWw> NF3HVYY2KGh? MXHEUXNQ MXfDfZRwfG:6aXPpeJkh[XO|ZYPz[YQh[XNiY3XscEBz\WynYYPl MUS4PVg5PjB2
SKVLB MkDLR5l1d3SxeHnjJGF{e2G7 M2q4RlczKGh? MmHiTWM2OD14LkW0JO69VQ>? MX65NFA{PTJy
MCF7/VP16 M3\NdGN6fG:2b4jpZ{BCe3OjeR?= MVG1NEDPxGdxbVy= MXi3NkBp NI\VWlBKSzVyPUG0MlIh|ryP NXHTfmE3QTB{Mke5Ni=>
CA755 M{nMSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TUSVExKM7:TR?= M{nWflYh\A>? NH;GUlZKSzVyPUCuNFE1KM7:TR?= NUHidG1LQTV{NkW3NC=>
CHO NIfTSoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXUNVAh|ryP MkHJOkBl NFfCUHVKSzVyPUCuNFYh|ryP NX\EeFhlQTV{NkW3NC=>
Panc02 NWnkdohPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\RTHEyOCEQvF2= NFfaSo43KGR? M2XV[mlEPTB;MD6wOlUh|ryP MWi5OVI3PTdy
PC14 M33xUGN6fG:2b4jpZ{BCe3OjeR?= M2\4dVQh\A>? M2Dz[mROW09? NF3IZ3dKSzVyPUCuNlkh|ryP M3HPcVk5OjJ3NEK=
HOP62 M{G3ZWN6fG:2b4jpZ{BCe3OjeR?= MlTQO|IhcA>? MWrJR|UxRTBwMEC0JO69VQ>? NX\sW4tpQTh5M{[2NS=>
SF-295 M33kbWN6fG:2b4jpZ{BCe3OjeR?= M4r2SVczKGh? MXXJR|UxRTBwMEO1JO69VQ>? Mnr2PVg4OzZ4MR?=
MDA-MB-361 MlXOR5l1d3SxeHnjJGF{e2G7 MYqxJIg> M1\IO2ROW09? MnrHR5l1d3SxeHnjbZR6KGGpYXnud5QhVUSDLV3CMVM3OSCneIDy[ZN{cW6pIFzhZ3ohf2m2aDDJR|UxKG:oIECuNFEzKM7:TR?= MnjzNVA{QTV2OUC=
MDA-MB-361 NWPnN|FyS3m2b4TvfIlkKEG|c3H5 NU[xNoR6OSCq MV\EUXNQ Ml\XR5l1d3SxeHnjbZR6KGGpYXnud5QhVUSDIF3CJFM3OSCneIDy[ZN{cW6pIHPhdoJwgHmyZYD0bYRie2Vic4TDVGczKHerdHigTWM2OCCxZjCwMlAyQCEQvF2= Mle5NVA{QTV2OUC=
CCRF-SB MnraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUi0JIQ> MULEUXNQ NIPm[mNKSzVyPUCuNFEh|ryP NHW5XYEyODRzMUS3Oi=>
CHO-K1 NWHi[YtPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPBO|k1KGR? Mo\ySG1UVw>? NUDvZZF6UUN3ME2wMlQh|ryP MXGxNFQyOTR5Nh?=
KB Mmr0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3j5SlQh\A>? MYDEUXNQ NGrmSW5CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIRzfWdvcnXzbZN1[W62IFvCO2Qhf2m2aDDJR|UxKG:oIECuOlUh|ryP MV[xNFQyOTR5Nh?=
KB M1TVXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1G3UFQh\A>? NELiPWpFVVOR NWX6eZJ3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBlenWpLYLld4l{fGGwdDDLRmNidXC5aYToJGlEPTBib3[gNE4xPiEQvF2= NXzRPG9jOTB2MUG0O|Y>
KB MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFH3WHc1KGR? NUXNNGlYTE2VTx?= MYnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHTyeYcuemW|aYP0ZY51KEuETVTSJJdqfGhiSVO1NEBw\iByLkWg{txO MmHMNVA1OTF2N{[=
KB NXvmR2ROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDDOEBl NEfEVo1FVVOR MlTORY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDkdpVoNXKnc3nzeIFvfCCNQm[yNGMhf2m2aDDJR|UxKG:oIECuOEDPxE1? NEPHeGoyODRzMUS3Oi=>
HTB-54 M{fzO2N6fG:2b4jpZ{BCe3OjeR?= M3f6N|ExOCEQvF2= NHz3NHdKSzVyPUGuNUDPxE1? NWDh[WxXOTB2N{[4OlE>
MEL-AC NVTWemw{S3m2b4TvfIlkKEG|c3H5 M3PsO|ExOCEQvF2= M37PWWlEPTB;MT6yJO69VQ>? M3HWWVExPDd4OE[x
DU145 NVPpcJNtS3m2b4TvfIlkKEG|c3H5 NHPNS5U4OiCq MXnJR|UxRTBwMEWyPEDPxE1? NHjjNnoyODR5OUK4Ni=>
K562R MkSxR5l1d3SxeHnjJGF{e2G7 Mm\TO|IhcA>? NGHx[2hKSzVyPUCuNFE2PiEQvF2= MUmxNFQ4QTJ6Mh?=
PACA-2 NYPsc2E6S3m2b4TvfIlkKEG|c3H5 M3\qOFYh\A>? NG\uW2hGTDVyPUCuNFA3OyEQvF2= NV6wd|ZoOTB2OUiyNVQ>
3Y1 M1XJOGN6fG:2b4jpZ{BCe3OjeR?= MY[3NkBp NH7sfmhIUTVyPUCuNFA{QCEQvF2= NXTPb3AzOTB4OUG3NVA>
P388 MnfIR5l1d3SxeHnjJGF{e2G7 MUS3NkBp M4G0e2dKPTB;MD6wNVIh|ryP MoS2NVA3QTF5MUC=
HMV-1 M{TlT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2q2WmlEPTB;MD6yPEDPxE1? MWOxNFY6QDR|Nh?=
MKN-1 NFLHZoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\tXWR3UUN3ME2wMlY1KM7:TR?= NH\TW2cyODZ7OESzOi=>
PC14 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PI[WlEPTB;MT65JO69VQ>? Mn;BNVA3QTh2M{[=
T24 NFnqUYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\rTWM2OD1yLk[0JO69VQ>? M1PhU|ExPjl6NEO2
U937 NUj0VHI6TnWwY4Tpc44hSXO|YYm= NELGZYMzPCCq NXzEfW9{TE2VTx?= NYniXmxDUW6qaXLpeJMhcW6lb4Lwc5JifGmxbjDv[kBcO0ifdHj5cYllcW6nIIfpeIghUUN3MDDv[kAxNjFizszN MmG4NVA4QDB7MUG=
H460pv8/eto M4PGUGN6fG:2b4jpZ{BCe3OjeR?= M3G0RVExOCEQvF2= MkDEOFghcA>? Ml34V4FtcW6n NYnyVJNZUUN3ME2wMlAzKM7:TR?= MnHNNVA4QDB7MUO=
H460pv8 MUjDfZRwfG:6aXOgRZN{[Xl? M2POclExOCEQvF2= NULlbpJ{PDhiaB?= MVXTZYxqdmV? NFnLdnBKSzVyPUCuNFA1KM7:TR?= MljCNVA4QDB7MUO=
MDA-231 NUnaV5drS3m2b4TvfIlkKEG|c3H5 MmPaNVAxKM7:TR?= MmXKOFghcA>? NGq4WWpU[WyrbnW= M{DmW2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2GQT2yN|Eh[2WubDCoSXIuNEWJRmKrMI12fGGwdDDwOVMqKHerdHigTWM2OCCxZjCwMlAxPiEQvF2= NGHCboEyODd6MEmxNy=>
MDA-468 M1rCZmN6fG:2b4jpZ{BCe3OjeR?= MYixNFAh|ryP M2XkcVQ5KGh? MkDCV4FtcW6n MXfDfZRwfG:6aXPpeJkh[WejaX7zeEBOTEFvNE[4JINmdGxiKFXSMUwh[W2ybHnmbYVlKEWJRmKsJI12fGGwdDDwOVMqKHerdHigTWM2OCCxZjCwMlAxPSEQvF2= NEG0UIEyODd6MEmxNy=>
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NCI-H720 NUDOdFZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXvTWM2OD12MT65O|I3KM7:TR?= M{X1NnNCVkeHUh?=
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NCI-H524 M1jB[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fRemlEPTB;NEiuPFI1QCEQvF2= NX[wfpBzW0GQR1XS

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

体内試験 In vivo, Doxorubicin in combination with adenoviral MnSOD (AdMnSOD) plus 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) has the greatest effect in decreasing the volumes of MB231 tumors and prolonging survival of mice. [1] Although its use is limited by the chronic and acute toxic side effects it produces, Doxorubicin is essential in treating breast and oesophageal carcinomas, solid tumours in childhood, osteosarcomas, Kaposi's sarcoma, soft tissue sarcomas, and Hodgkin and non-Hodgkin lymphomas. [2]

お薦めの試験操作(参考用のみ)

動物試験:[1]
+ 展開
  • 動物モデル: Female athymic nude mice injected s.c. with MB231 cells
  • 製剤: Dissolved in DMSO, and diluted in saline
  • 投薬量: 3 mg/kg/day
  • 投与方法: Delivered intratumorly
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 100 mg/mL (172.41 mM) warming
Water 20 mg/mL (34.48 mM)
Ethanol Insoluble

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 579.98
化学式

C27H29NO11.HCl

CAS No. 25316-40-9
保管
in solvent
別名 NSC 123127

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01489371 Active not recruiting Ovarian Clear Cell Cystadenocarcinoma|Ovarian Endometrioid Adenocarcinoma|Ovarian Seromucinous Carcinoma|Ovarian Serous Cystadenocarcinoma|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma|Undifferentiated Ovarian Carcinoma Gynecologic Oncology Group|National Cancer Institute (NCI) July 9 2012 Phase 1
NCT02751918 Recruiting Ovarian Neoplasms Bayer June 8 2016 Phase 1
NCT00722293 Completed Neoplasms Breast GlaxoSmithKline July 8 2008 Phase 1
NCT03301350 Suspended Breast Cancer|Triple Negative Breast Cancer University of Wisconsin Madison|National Cancer Institute (NCI) November 7 2017 Phase 2
NCT02979522 Recruiting Hodgkin Disease Millennium Pharmaceuticals Inc.|Takeda September 7 2017 Phase 1|Phase 2
NCT03399747 Enrolling by invitation Diffuse Large B-cell Lymphoma Asan Medical Center December 7 2016 Phase 2

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    Why the IC50 of the compound varied over time in our measurement?

  • 回答:

    Sometimes the IC50 value might vary between different batch of compounds due to the slight differences in purity. If different IC50 was seen in the same batch of compound, the problem may lies in the process of dissolvement. Make sure that you see no particles and the solution is clear with your stock solution.

Topoisomeraseシグナル伝達経路

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