Doxorubicin (Adriamycin) HCl

Licensed by Pfizer 製品コードS1208 別名:NSC 123127

Doxorubicin (Adriamycin) HCl化学構造

分子量(MW):579.98

Doxorubicin (Adriamycin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.

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JPY 14940.00
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文献中Selleckの製品使用例(36)

カスタマーフィードバック(10)

  • Enhancement of apoptotic response by addition of targeted agents lapatinib and sunitinib to doxorubicin in the same device reservoir at 24 hours. P values were determined using Student’s t test for all graphs.

    Sci Transl Med, 2015, 7(284): 284ra57 . Doxorubicin (Adriamycin) HCl purchased from Selleck.

    (F) Kaplan-Meier curves are shown for all groups described: no hydrogel, a hydrogel loaded with paclitaxel, or a hydrogel loaded with doxorubicin. The number of mice per group (n) and median survival (ms) are listed. The experiment was performed at least three times.

    Science, 2018, 10(433), doi: 10.1126/scitranslmed.aar1916. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • MM.1S cells inducibly expressing shRNA targeting SIRT6 were grown with or without doxycycline, and then treated with vehicle, doxorubicin (Doxo; 1 μM) or melphalan (mel; 100 μM) for 1 hour prior to the preparation of lysates and analyzed by western blotting. Representative immunoblots (n = 3) for the indicated proteins in MM cells are shown.

    Blood, 2016, 127(9):1138-50. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    Cell viabilities with increasing concentrations of cisplatin (CP) and doxorubicin (DOXO) under normoxic and hypoxic condition for 48 hours were determined by MTT assay. IC50 values are presented as the means ?SDs (n=4) and * denotes p<0.05.

    Cancer Res 2014 74, 298-308. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • Cleavage of caspase-3, -9 and the expression of PARP were measured by western blot using b-actin as a loading control.

    Cell Cycle, 2017, 16(5):468-476. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    (C) & (D) Treatments with doxorubicin, cisplatin or AZD6244 further decreased the cell viability in RH30 cloned cells in which STAT3 or GP130 was knockdown by shRNA. (*P<.05, ** P <.01, *** P <.001).

    Curr Cancer Drug Targets, 2016, 16(7):631-8. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  •  

    Doxorubicin release of P(MAA-g-EG) and P(MAA-g-EG) containing nanoparticles in two-step pH conditions. Doxorubicinloaded P(MAA-g-EG) ,P(MAA-g-EG)-1.0NP ,P(MAA-g-EG)-2.5NP, and P(MAA-g-EG)-5.0NP crushed particles (75–150 um) were released in 1 PBS (pH 2.0) for 90 min. Then the pH was increased to 7.0 by adding 5N NaOH and release continued for 6 h.

    J Biomed Mater Res Part A 2012 10.1002/jbm.a.34064. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    Temporal uptake of free DOX or DOX-PCL63-b-PNVP90 micelles into K-562 (I) and DL (J) cells were studied by incubating in 24-well plates at a concentration of 50,000 cells per well. Representative images shown were obtained using a fluorescence microscope Eclipse 80i (Nikon, Japan) (Plan Fluor, 40X, NA 0.75 objective) equipped with blue and red filters for, Hoechst and Doxorubicin respectively (n = 3).

    PLoS One 2014 9, e94309. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • PLoS One 2013 8(1), e54595. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    CON+ -positive control (with FBS as chemoattractant); CON- - negative control (without chemoattractant); DOX -doxorubicin; WZ -WZ811; PF- PF-573228; * -significant difference compared to positive control: p<0.05; ** -significant difference compared to positive control: p<0.01; # -significant difference between combination and inhibitor only: p<0.05. Cancer cell invasion was analyzed using Transwell membranes assembled in 24-well plates and covered with a layer of Matrigel. COR-L23 cells were treated for 24 h with 50 nM DOX, 10 uM WZ811, 5 uM PF-573228 and combinations of inhibitors with 50 nM DOX. Similarly, RH460 cells were treated for 24 h with 1 uM DOX, 10 uM WZ811, 2.5 uM PF-573228 and combinations of inhibitors with 1 uM DOX. Applied doses were the ones that exerted the most pronounced synergistic effect on cytotoxicity level. After the incubation period, cells that invaded through matrigel and membranes were fixed in 4% paraformaldehyde-PBS and stained with Hoechst 33342 nuclear stain. Cells were visualized and counted under a fluorescent microscope at 10x magnification.

    2014 Dr Milica Pesic from Institute for Biological Research. Doxorubicin (Adriamycin) HCl purchased from Selleck.

製品安全説明書

Topoisomerase阻害剤の選択性比較

生物活性

製品説明 Doxorubicin (Adriamycin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.
ターゲット
Topo II [1]
(Tumor cells)
体外試験

Doxorubicin, an antibiotic anthracycline, is commonly considered to exert its anti-tumor activity at two fundamental levels, altering DNA and producing free radicals to trigger apoptosis of cancer cells through DNA damage. Doxorubicin can block the synthesis of DNA by intercalating into the DNA strand, and inhibits DNA topoisomerase II (TOP2). Doxorubicin is most effective when cells are rapidly proliferating and expressing high levels of TOP2. Additionally, Doxorubicin can trigger apoptosis by producing ceramide (which prompts apoptosis by activating p53 or other downstream pathways such as JNK), the degradation of Akt by serine threonine proteases, the mitochondrial release of cytochrome c, increased FasL (death receptor Fas/CD95 ligand) mRNA production, and a greater production of free radicals. [2] Pre-treatment with GSNO (nitrosoglutathione) suppresses the resistance in the doxorubicin-resistant breast cancer cell line MCF7/Dx, accompanied by enhanced protein glutathionylation and accumulation of doxorubicin in the nucleus. [3] Doxorubicin induced G2/M checkpoint arrest are attributed to elevated cyclin G2 (CycG2) expression and phospho-modification of proteins in the ataxia telangiectasia mutated (ATM) and ATM and Rad3-related (ATR) signaling pathways. [5] Doxorubicin inhibits AMP-activated protein kinase (AMPK), resulting in SIRT1 dysfunction, p53 accumulation, and increased cell death in mouse embryonic fibroblasts (MEFs) and cardiomyocytes, which can be further sensitized by pre-inhibition of AMPK. [6] Doxorubicin elicits a marked heat shock response, and that either inhibition or silencing of heat shock proteins enhance the Doxorubicin apoptotic effect in neuroblastoma cells. Nanomolar Doxorubicin treatment of neuroblastoma cells causes dose-dependent over-ubiquitination of a specific set of proteins in the absence of measurable inhibition of proteasome, and loss of activity of ubiquitinated enzymes such as lactate dehydrogenase and α-enolase, the protein ubiquination patterns of which is similar to those with proteasome inhibitor Bortezomib, indicating that Doxorubicin may also exert its effect by damaging proteins. [8]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
L1210 M4m4OmZ2dmO2aX;uJGF{e2G7 M1nBWmlvcGmkaYTpc44hd2ZiUl7BJJN6dnSqZYPpd{B4cXSqIFXEOVAhd2ZiMD61PEDPxE1? NV30c5B5PDlyNUO2
Yoshida sarcoma NFnCfVhHfW6ldHnvckBCe3OjeR?= NEPXTI5KdmirYnn0bY9vKG:oIGuzTH1V\FJiaX7jc5Jxd3KjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNkDPxE1? NGrsVmEyOzJ{OUi2
CHO MoCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rLOGlEPTB;MD6wOkDPxE1? NG\xUG0yOzV2N{Ww
8226 NF;ZN4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwMEOzJO69VQ>? NX:xOVRHOTR2N{ezNC=>
8226/ADR NWPWSVV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fzb2lEPTB;MD61OkDPxE1? M4\5WFE1PDd5M{C=
MCF7/ADR NH[xTI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4ixdGlEPTB;Mz6xJO69VQ>? MmHXNVQ1Pzd|MB?=
H69 NYPvcpk{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TlNWlEPTB;MD64O{DPxE1? NX;1[JdDOTR5OUW4OS=>
N417 Mn3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoL3TWM2OD1yLkKzJO69VQ>? M3\sO|E1Pzl3OEW=
H9 NX35V3B3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJcohq[mm2aX;uJI9nKEh7IHPlcIx{KGOqcn;ubYNidGy7IHnu[oVkfGWmIIfpeIghfGinIFjJWk0yKCiKOT;JTWlDMSC5aYToJGlFPTBib3[gNE4xOSEQvF2= NV6zbZY5OTV2OE[4NS=>
T-C8166 NFn0RYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJSFUxRTBwMEGg{txO MmKxNVU1QDZ6MR?=
T-H9 M2rOdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofJTWQ2OD1yLkCxJO69VQ>? NYq2ZXVpOTV2OE[4NS=>
T-MT4 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvCTWQ2OD1yLkCxJO69VQ>? MlnDNVU1QDZ6MR?=
SKMEL-5 NHPFWppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{ToZWVFPTB;Mz6yJO69VQ>? MlP1NVYyOzd3Mx?=
MLM MV3DfZRwfG:6aXOgRZN{[Xl? Ml7FSWQ2OD1yLkGzJO69VQ>? M2HkOlE5PzV|NUC=
KBM-3 MkT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHkTWM2OD1yLkCyOkDPxE1? MY[xPVk2QDd5
HT-29 M2rVNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEmxXYkxNjBzIN88[y=> MX60PEBp MW\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eR?= MVKyO|c5PDR7
EMT6 M4LlRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYCwMlUh|ryP NWPLN3lEOSCq NHO2PYxKdmirYnn0bY9vKG:oIIDyc4xq\mW{YYTpc44h[nlibXXhd5VzcW6pIH\vdkB{fXK4aY\pcoch\nKjY4Tpc45{KHerdHigSWQ2OCCxZjCwMlAxODFizszN MnjmO|Q2OjZ5NB?=
H2981 M1TXTmN6fG:2b4jpZ{BCe3OjeR?= NH36[YJKSzVyPUCuOUDPxE1? M363[|c4OzFyMkO=
LOX MXPDfZRwfG:6aXOgRZN{[Xl? MmDLTWM2OD1yLkC0NkDPxE1? M2Ky[Fc5PTN|M{G=
C38 NEnTSWtEgXSxdH;4bYMhSXO|YYm= M2O0SWlEPTB;MD6wNUDPxE1? M4DqXlgxPTd{OUG=
EAC MnPpR5l1d3SxeHnjJGF{e2G7 NV2yRohYPzJiaB?= M1P4d2lEPTB;MD6zOUDPxE1? NIizVlE5OzVyMEi3
SKVLB NFr3enBEgXSxdH;4bYMhSXO|YYm= MmnxTWM2OD13Lk[g{txO NWi1cHlPQDV5NkmxOC=>
AUC375 NIf3UWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHWxVYZKSzVyPUCuNVEzKM7:TR?= NHvkRlk5PjR6NkCw
A2780-C25 NYfR[GFyS3m2b4TvfIlkKEG|c3H5 NXn2U5V7S3m2b4TvfIlkcXS7IHHnZYlve3Rib4jhcIlxdGG2aX6tdoV{cXO2YX70JGEzPzhyLVOyOUB4cXSqIFnDOVAhd2ZiMD6wOlMh|ryP M2fMXFg5OzF5NUW=
A2780-CP3 NHfrXopEgXSxdH;4bYMhSXO|YYm= MoXIR5l1d3SxeHnjbZR6KGGpYXnud5Qh[2m|cHzheIlvNXKnc3nzeIFvfCCDMke4NE1EWDNid3n0bEBKSzVyIH;mJFAvODV4IN88US=> MkfuPFg{OTd3NR?=
A2780-DX5 NWDLbIR5S3m2b4TvfIlkKEG|c3H5 MVjDfZRwfG:6aXPpeJkh[WejaX7zeEBld3ixcoXibYNqdi2{ZYPpd5RidnRiQUK3PFAuTFh3IIfpeIghUUN3MDDv[kAxNjN3NzFOwG0> NXHNN4p3QDh|MUe1OS=>
MXF7 NFTXbndEgXSxdH;4bYMhSXO|YYm= MXPBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDz[Y5{cXSrdnWgUXhHPyC5aYToJGlEPTBib3[gNE4xOjhizszN NUXWT5dkQDl4MEW1PC=>
MXF7 M3Hm[mN6fG:2b4jpZ{BCe3OjeR?= M{fCV2FvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JI1qfG:6YX70do9v\S2{ZYPpd5RidnRiTWjGO{B4cXSqIFnDOVAhd2ZiMD6wNlgh|ryP Mn\xPFk3ODV3OB?=
MXF7 M{HBTWN6fG:2b4jpZ{BCe3OjeR?= M1K2dWFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIRwgG:{dXLpZ4lvNXKnc3nzeIFvfCCPWF[3JJdqfGhiSVO1NEBw\iBzLkG3NkDPxE1? MXq4PVYxPTV6
WiDr MmTXR5l1d3SxeHnjJGF{e2G7 MoPRRYN1cX[rdImgZYdicW6|dDDz[Y5{cXSrdnWgW4lFeiClZXzsJJdqfGhiSVO1NEBw\iByLkC1N{DPxE1? MXO4PVYxPTV6
MCF MVjGeY5kfGmxbjDBd5NigQ>? M2nxbXJmfmW{c3HsJI9nKFBvZ4CtcYVlcWG2ZXSgcZVtfGmmcoXnJJJme2m|dHHuZ4Uh[XO|ZYPz[YQh[XNiZX7oZY5k\W2nboSgbY4h[3m2b4TvfIlkcXS7IH;mJIFlemmjbYnjbY4> Ml7nPFk5PDF3MR?=
C6 NHTnWJNEgXSxdH;4bYMhSXO|YYm= NGPSdmEzNjVibXevcWw> NX7FfG9VPzJiaB?= NHnpXWFFVVOR M2P3OWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KHKjdDDDOkBk\WyuczDheEA2OCC3Zz;tUEB1dyB{LkWgcYcwdUx? NV3CXHhuQDl6OE[wOC=>
C6 MULGeY5kfGmxbjDBd5NigQ>? MlvZNk42KG2pL33M M4LnNVQhcA>? NVLsXnVjTE2VTx?= NFXBe3ZKdmirYnn0bY9vKG:oIIT1ZpVtcW5icH;sfY1memm8YYTpc44> MonBPFk5QDZyNB?=
C6 NV3ycndyS3m2b4TvfIlkKEG|c3H5 NV;jTZhXOi53IH3nM41N M4fNOlUhcA>? M13wOmROW09? MnPsR5l1d3SxeHnjbZR6KGG|c3Xzd4VlKGG|IHPlcIwhemWuZXHz[S=> NI\tbII5QTh6NkC0
SKVLB M3\HdWN6fG:2b4jpZ{BCe3OjeR?= NFnXOnQ4OiCq NFSwc|RKSzVyPU[uOVQh|ryP M4exUlkxODN3MkC=
MCF7/VP16 MoPTR5l1d3SxeHnjJGF{e2G7 MYq1NEDPxGdxbVy= M3rkO|czKGh? MVfJR|UxRTF2LkKg{txO M3TGPFkxOjJ5OUK=
CA755 MoH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYL3R2xkOTBizszN MYO2JIQ> NGHG[FZKSzVyPUCuNFE1KM7:TR?= NIL0U|I6PTJ4NUew
CHO NH;mV4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnEdnkyOCEQvF2= NXn6cYl3PiCm NWnYbpRnUUN3ME2wMlA3KM7:TR?= M3z2elk2OjZ3N{C=
Panc02 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV2zTldDOTBizszN NF;5b283KGR? MXXJR|UxRTBwME[1JO69VQ>? MUm5OVI3PTdy
PC14 MnXVR5l1d3SxeHnjJGF{e2G7 M{jKR|Qh\A>? M4DadGROW09? NXmzZW5vUUN3ME2wMlI6KM7:TR?= NXuzeoRIQTh{MkW0Ni=>
HOP62 MVXDfZRwfG:6aXOgRZN{[Xl? NWX6OYdDPzJiaB?= NF25dnFKSzVyPUCuNFA1KM7:TR?= NFPY[4w6QDd|Nk[x
SF-295 MoHuR5l1d3SxeHnjJGF{e2G7 MUm3NkBp NI\NUXhKSzVyPUCuNFM2KM7:TR?= MUS5PFc{PjZz
MDA-MB-361 M{G5W2N6fG:2b4jpZ{BCe3OjeR?= M1i4e|EhcA>? M{jyTmROW09? MUPDfZRwfG:6aXPpeJkh[WejaX7zeEBOTEFvTVKtN|YyKGW6cILld5NqdmdiTHHjXkB4cXSqIFnDOVAhd2ZiMD6wNVIh|ryP MU[xNFM6PTR7MB?=
MDA-MB-361 M2TtXGN6fG:2b4jpZ{BCe3OjeR?= M{fOdVEhcA>? NWjCOJNRTE2VTx?= MWjDfZRwfG:6aXPpeJkh[WejaX7zeEBOTEFiTVKgN|YyKGW6cILld5NqdmdiY3HyZo95gXCncITp[IF{\SC|dFPQS|Ihf2m2aDDJR|UxKG:oIECuNFE5KM7:TR?= NHSwR20yODN7NUS5NC=>
CCRF-SB MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnH1OEBl MWjEUXNQ NFjHOZRKSzVyPUCuNFEh|ryP NGLBU4kyODRzMUS3Oi=>
CHO-K1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDkOEBl NI\OTYtFVVOR MVLJR|UxRTBwNDFOwG0> NWfl[XhwOTB2MUG0O|Y>
KB MkHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTpU|hzPCCm Ml;HSG1UVw>? MUjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHTyeYcuemW|aYP0ZY51KEuEN1Sge4l1cCCLQ{WwJI9nKDBwNkWg{txO MYOxNFQyOTR5Nh?=
KB NV7nc5oxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zRW|Qh\A>? MWnEUXNQ NYrke5JxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBlenWpLYLld4l{fGGwdDDLRmNidXC5aYToJGlEPTBib3[gNE4xPiEQvF2= NX:0XHM{OTB2MUG0O|Y>
KB M{\l[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;xNHA1KGR? MUTEUXNQ NH3wZ4JCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIRzfWdvcnXzbZN1[W62IFvCUWRTKHerdHigTWM2OCCxZjCwMlUh|ryP Mo\ONVA1OTF2N{[=
KB M{TBXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETtOHE1KGR? NI\zT3hFVVOR MXfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHTyeYcuemW|aYP0ZY51KEuEVkKwR{B4cXSqIFnDOVAhd2ZiMD60JO69VQ>? M2L2eFExPDFzNEe2
HTB-54 NIXs[5REgXSxdH;4bYMhSXO|YYm= M37JVFExOCEQvF2= MXnJR|UxRTFwMTFOwG0> Mn7uNVA1PzZ6NkG=
MEL-AC NWDjdoxLS3m2b4TvfIlkKEG|c3H5 MX2xNFAh|ryP NGP6bJBKSzVyPUGuNkDPxE1? M1\uVVExPDd4OE[x
DU145 NETud3dEgXSxdH;4bYMhSXO|YYm= MmTLO|IhcA>? NHj3bJFKSzVyPUCuNFUzQCEQvF2= NVzoSJRjOTB2N{myPFI>
K562R MXvDfZRwfG:6aXOgRZN{[Xl? NF3DUHY4OiCq MkLLTWM2OD1yLkCxOVYh|ryP NV3abG5JOTB2N{myPFI>
PACA-2 M{TzOmN6fG:2b4jpZ{BCe3OjeR?= NEfreG43KGR? M1fNbWVFPTB;MD6wNFY{KM7:TR?= NUG3[5dPOTB2OUiyNVQ>
3Y1 MkjpR5l1d3SxeHnjJGF{e2G7 NVX6RWVUPzJiaB?= NXzXTZNwT0l3ME2wMlAxOzhizszN NXvnd5J2OTB4OUG3NVA>
P388 MnfDR5l1d3SxeHnjJGF{e2G7 MnOwO|IhcA>? MVfHTVUxRTBwMEGyJO69VQ>? M3T1fFExPjlzN{Gw
HMV-1 M3PBeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV6yNWVzUUN3ME2wMlI5KM7:TR?= M17LNVExPjl6NEO2
MKN-1 M1L5d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPiTWM2OD1yLk[0JO69VQ>? MkLpNVA3QTh2M{[=
PC14 M3GxdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrqXFJ2UUN3ME2xMlkh|ryP MYWxNFY6QDR|Nh?=
T24 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLpTWM2OD1yLk[0JO69VQ>? M17u[|ExPjl6NEO2
U937 NFf2fXJHfW6ldHnvckBCe3OjeR?= NU[5[ndSOjRiaB?= NH7KTGJFVVOR M1fi[2lvcGmkaYTzJIlv[2:{cH;yZZRqd25ib3[gX|NJZXSqeX3p[Ilv\SC5aYToJGlEPTBib3[gNE4yKM7:TR?= NHnzT5EyODd6MEmxNS=>
H460pv8/eto NH;POZhEgXSxdH;4bYMhSXO|YYm= M3KzT|ExOCEQvF2= M1naOlQ5KGh? M1nUUHNidGmwZR?= MWPJR|UxRTBwMEKg{txO NYP4SFdQOTB5OEC5NVM>
H460pv8 M2XvT2N6fG:2b4jpZ{BCe3OjeR?= MkXVNVAxKM7:TR?= NETHUJU1QCCq M3\uPXNidGmwZR?= NXjsc4NRUUN3ME2wMlAxPCEQvF2= NEG3T24yODd6MEmxNy=>
MDA-231 M37RO2N6fG:2b4jpZ{BCe3OjeR?= NXHmNlFwOTByIN88US=> MWC0PEBp NYWzXI1xW2GuaX7l M3r0fGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2GQT2yN|Eh[2WubDCoSXIuNEWJRmKrMI12fGGwdDDwOVMqKHerdHigTWM2OCCxZjCwMlAxPiEQvF2= MVyxNFc5ODlzMx?=
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RPMI-8402 M2nOUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;aSmlEPTB;NUOuPFYhdk1? MYTTRW5ITVJ?
Calu-3 NI\6VohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33DbWlEPTB;NUWuPVghdk1? M4fBS3NCVkeHUh?=
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NCI-H1694 NG\hc5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHe4[XRKSzVyPUKwNE4zPiCwTR?= NF3RcVdUSU6JRWK=
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LB831-BLC NWDGWZNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDGTWM2OD1{ME[uNlUhdk1? MWLTRW5ITVJ?
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GB-1 MmXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTJzMj63N{BvVQ>? M{\IUnNCVkeHUh?=
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NCI-H1882 NILoVY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjQ[5ZuUUN3ME2yNVUhdk1? MojlV2FPT0WU
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HO-1-N-1 NVLBbI4{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;6TWM2OD1{MkKuPFMhdk1? NGDqcFdUSU6JRWK=
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NCI-H838 MmXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTJ{ND63N{BvVQ>? MmexV2FPT0WU
NY NGjST5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XQcWlEPTB;MkK4MlQ6KG6P MnW5V2FPT0WU
NCI-H2196 NFjo[3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\j[mFKSzVyPUKyPU4yPSCwTR?= NITYcnBUSU6JRWK=
FTC-133 Mm[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTJ{OT6zO{BvVQ>? MkmzV2FPT0WU
MHH-PREB-1 NEXEcZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHPemtKSzVyPUKyPU45OiCwTR?= NUTW[ot7W0GQR1XS
SK-MEL-2 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moe3TWM2OD1{M{CuN{BvVQ>? NVjVTlVsW0GQR1XS
Detroit562 Mn\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M175eGlEPTB;MkOwMlczKG6P NVHJW2ZrW0GQR1XS
NCI-H2405 NEO4fIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\0TYFKSzVyPUKzOE4yKG6P MXfTRW5ITVJ?
NCI-H2081 MkfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;4TWM2OD1{M{SuNlchdk1? M17RSHNCVkeHUh?=
LB2241-RCC MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXS2Xm5tUUN3ME2yN|UvOTFibl2= M1nS[XNCVkeHUh?=
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PC-14 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjnfHl7UUN3ME2yN|YvOTJibl2= MnrwV2FPT0WU
CAS-1 M{fzcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnL0TWM2OD1{M{iuN|Ehdk1? MnvlV2FPT0WU
TE-11 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPUTWM2OD1{NECuPFghdk1? NWPYbmtsW0GQR1XS
LC4-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTJ2MD64PUBvVQ>? NGTEfIVUSU6JRWK=
HH Mon4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTJ2MT60OkBvVQ>? MWPTRW5ITVJ?
JVM-2 MmLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjUbplyUUN3ME2yOFIvOTdibl2= NWKzfIhvW0GQR1XS
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T-24 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnuTWM2OD1{NEWuOFghdk1? NFLwZnpUSU6JRWK=
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KOSC-2 MlTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;NO2lEPTB;MkS4MlcyKG6P NXy1WGtYW0GQR1XS
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BV-173 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTJ3MD63O{BvVQ>? M3vCdXNCVkeHUh?=
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KYSE-520 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTJ4MD63O{BvVQ>? M4PmT3NCVkeHUh?=
NCI-H520 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTJ4Nj62NUBvVQ>? NITTfolUSU6JRWK=
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AM-38 NFPzZnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\T[2lEPTB;MkixMlUzKG6P MU\TRW5ITVJ?
NCI-H23 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTJ6Mz65NkBvVQ>? M1K4[nNCVkeHUh?=
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SKG-IIIa MmrPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\yTWM2OD1|MUGuNVQhdk1? MWjTRW5ITVJ?
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NCI-H1304 M1r3emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3i4WmlEPTB;M{KxMlE4KG6P NFzPbHRUSU6JRWK=
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L-363 MnvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTN{ND60N{BvVQ>? MYfTRW5ITVJ?
EM-2 NIDYc2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml6zTWM2OD1|MkWuOFEhdk1? M2XmZ3NCVkeHUh?=
DV-90 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzLTWM2OD1|MkmuOFUhdk1? NV7BUZVGW0GQR1XS
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KY821 NXLQVWozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fLemlEPTB;MT60PVQzQSEQvF2= MU\TRW5ITVJ?
MDA-MB-231 Mkn6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37PdWlEPTB;MT61N|A2PSEQvF2= Mki5V2FPT0WU
NCI-H82 MmPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4q5ZmlEPTB;MT61O|AzPiEQvF2= MWnTRW5ITVJ?
MDA-MB-134-VI NW\SOJVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTFwNkG3NVEh|ryP NFLSdHdUSU6JRWK=
PANC-08-13 NVToeGU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fXTWlEPTB;MT62N|A5PCEQvF2= NWnlcVdmW0GQR1XS
D-542MG NFTa[HpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml:0TWM2OD1zLk[1N|A2KM7:TR?= NGri[WRUSU6JRWK=
LC-1F MnHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTFwNk[yNFMh|ryP M4Dpe3NCVkeHUh?=
KP-N-YN NXu5R|NTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTFwNk[zOFMh|ryP NW\0SYx6W0GQR1XS
MFE-280 NUm5d5ZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3m1emlEPTB;MT62OlgyOiEQvF2= MVTTRW5ITVJ?
S-117 M3Ly[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTFwN{C1NFQh|ryP NHHWVolUSU6JRWK=
NCI-H1573 NVrBd|RuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4r4eGlEPTB;MT63NVc{OyEQvF2= Mmn5V2FPT0WU
BT-20 M2rrdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfxd29KSzVyPUGuO|QxPjhizszN NEfn[WZUSU6JRWK=
NCI-H28 Moe4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;NTWM2OD1zLke0NFc5KM7:TR?= M4rGdnNCVkeHUh?=
CaR-1 M4i5OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTFwN{izNlQh|ryP NVO4ZVV1W0GQR1XS
LN-405 NGTqWodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPpZopKSzVyPUGuPFAyPDNizszN NHfnU49USU6JRWK=
RT4 Mm\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHu3VYZKSzVyPUGuPFQ1OTdizszN NXTGbpJYW0GQR1XS
NCI-H889 NXXV[3RbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzhd4I5UUN3ME2xMlk{QDh4IN88US=> MkmxV2FPT0WU
SW1463 NGjXRplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXftVWV1UUN3ME2xMlk2PzBzIN88US=> NYe4b5dmW0GQR1XS
SCLC-21H MkXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHidnlPUUN3ME2yMlAxPjJ2IN88US=> MVfTRW5ITVJ?
CP66-MEL NHO3foNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljsTWM2OD1{LkCxO|Y4KM7:TR?= NVzOPZFPW0GQR1XS
Hs-578-T NHvVRmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTJwMEG3PFIh|ryP NHXIWHRUSU6JRWK=
HCC70 NE\LVoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEi4ZW9KSzVyPUKuNFU1PjNizszN M3rLVHNCVkeHUh?=
SW1088 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLIZYRqUUN3ME2yMlA3QTNzIN88US=> M3PvbnNCVkeHUh?=
NB6 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXadmp{UUN3ME2yMlE5PSEQvF2= MWPTRW5ITVJ?
KU-19-19 M{WzOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrKV5Z6UUN3ME2yMlI3QTF5IN88US=> NWj4b4VtW0GQR1XS
A704 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHBTWM2OD1{LkK5NVM2KM7:TR?= MYjTRW5ITVJ?
EVSA-T M37US2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3O[3AxUUN3ME2yMlMxODh7IN88US=> NF\kcYpUSU6JRWK=
HCT-15 Mmq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\nTWM2OD1{LkO1OFY3KM7:TR?= NGixb3dUSU6JRWK=
HuO-3N1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTJwM{[1PFMh|ryP Mo\QV2FPT0WU
GMS-10 MlvLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\2TWM2OD1{LkO5O|M5KM7:TR?= NWq5PHZRW0GQR1XS
TGBC24TKB MlO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDrTWM2OD1{LkSxOFI6KM7:TR?= Mm\hV2FPT0WU
C2BBe1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHyVHJKSzVyPUKuOVE{OjhizszN M3KySHNCVkeHUh?=
SK-N-DZ M4fTVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLwcXFKSzVyPUKuOVY2QTJizszN MXzTRW5ITVJ?
SK-N-AS MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDrR3FDUUN3ME2yMlc{ODF3IN88US=> NYH0OYpLW0GQR1XS
T98G NHTUUZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml74TWM2OD1{LkiwOFAyKM7:TR?= MXrTRW5ITVJ?
DMS-79 M4nIUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HlVGlEPTB;Mj65NFk5QCEQvF2= M1nPeXNCVkeHUh?=
SNU-475 MoPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mon0TWM2OD1{LkmyOVczKM7:TR?= MVvTRW5ITVJ?
COLO-792 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfBOWhKSzVyPUOuNFI5PyEQvF2= M4H1U3NCVkeHUh?=
YAPC MoPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{KwfWlEPTB;Mz6zNlg{OiEQvF2= NHi4V2dUSU6JRWK=
UACC-812 MljTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7Kc|FKSzVyPUOuN|M4OzhizszN MUjTRW5ITVJ?
Mewo MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzISphKSzVyPUOuOFYxQDZizszN MkTBV2FPT0WU
COLO-824 M{LVXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXW0UYxPUUN3ME2zMlU4Ozd6IN88US=> MlPkV2FPT0WU
SCC-9 NX7scFZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLCZ3JlUUN3ME2zMlkyOzB7IN88US=> NYH0N5lRW0GQR1XS
CP50-MEL-B MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHe5UpdKSzVyPUOuPVg4ODNizszN NXnNWVB[W0GQR1XS
NCI-H345 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTRwMEGxO|Qh|ryP MnSxV2FPT0WU
COR-L88 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\wTWM2OD12LkO5OVgh|ryP MlHqV2FPT0WU
RCM-1 MonNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFv2[XlKSzVyPUSuOFkzPzJizszN NGPiZZpUSU6JRWK=
JVM-3 M2LUT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7KfWdWUUN3ME20MlYxPjF6IN88US=> M1TqcXNCVkeHUh?=
ECC4 M1S1XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmmxTWM2OD12Lke2OVQyKM7:TR?= MYLTRW5ITVJ?
MDA-MB-453 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF[2dmRKSzVyPUSuPFUyOzRizszN NFX4Z|JUSU6JRWK=
SK-N-FI MoCzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjSTWM2OD13LkKyPFc4KM7:TR?= MVHTRW5ITVJ?
D-502MG MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{L3NmlEPTB;NT6yOFI3OiEQvF2= NGrle|BUSU6JRWK=
NCI-H2227 NXXlcpFFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEL6T2VKSzVyPUWuN|YzOzFizszN NX;vfoNpW0GQR1XS
DMS-53 MnPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTZwMUexNFYh|ryP Mnu0V2FPT0WU
LB771-HNC NETyPVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DiZmlEPTB;Nj60OlgxPiEQvF2= NXnrRZgyW0GQR1XS
BB49-HNC M1jMUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfNW2RKSzVyPUeuOFE4QTFizszN MYTTRW5ITVJ?
MDA-MB-415 NWHEbWJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTdwNUezNFMh|ryP MnG3V2FPT0WU
TALL-1 NID3eIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7LNWlKSzVyPUeuPVY5QCEQvF2= NFT5eo1USU6JRWK=
HCC1395 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml20TWM2OD16LkG1NVIzKM7:TR?= NIjCZ4NUSU6JRWK=
EFE-184 MmTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXrZWNqUUN3ME24MlM4OjF4IN88US=> M4nSN3NCVkeHUh?=
EC-GI-10 NFTMdWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TDO2lEPTB;OD62PFY5PiEQvF2= Ml\ZV2FPT0WU
TT NF6yRoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4qxbmlEPTB;OT6wOlk3PiEQvF2= NHXFTmJUSU6JRWK=
U-2-OS NIjTco9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTlwOEGzPVMh|ryP M4LsT3NCVkeHUh?=
SHP-77 NVvwfFY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2niXWlEPTB;OT65NFI6KM7:TR?= NVvwdYJSW0GQR1XS
HCC1143 Mli4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3JVJhMUUN3ME2xNE41Pzl5IN88US=> MV;TRW5ITVJ?
A498 Mn[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknHTWM2OD1zOD6yPVc3KM7:TR?= MWfTRW5ITVJ?
LS-513 NVL2PWxYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFm0W2NKSzVyPUG4MlYxQTNizszN MVLTRW5ITVJ?
K052 M2i0Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETGdodKSzVyPUKxMlQ1OThizszN MVHTRW5ITVJ?
SiHa NXqwRVBTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTGPGxKSzVyPUKzMlM{PzFizszN MoDtV2FPT0WU
RCC10RGB NHHKNm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTNyLkC2NVEh|ryP M4rpRXNCVkeHUh?=
NCI-SNU-16 Mn7GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrZTWM2OD1|MT6xPFM3KM7:TR?= MWTTRW5ITVJ?
SNU-C1 M4Dibmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vjOmlEPTB;M{KuOFE4PSEQvF2= M1HtU3NCVkeHUh?=
C32 NFfPPJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTN{Lki3NkDPxE1? NIPtWllUSU6JRWK=
SW684 NGrRV4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo[5TWM2OD1|ND6xOVYyKM7:TR?= M3LCfnNCVkeHUh?=
SK-MEL-28 MmfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfpTWM2OD1|NT61N|c4KM7:TR?= NW\0OXY4W0GQR1XS
SK-MEL-1 MmrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnHTWM2OD1|Nj63OVQ4KM7:TR?= M2jtUXNCVkeHUh?=
NCI-H720 MlXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfmVWpzUUN3ME20NU46PzJ4IN88US=> MV;TRW5ITVJ?
P31-FUJ M16yS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jmSGlEPTB;NESuN|I5PCEQvF2= MV7TRW5ITVJ?
NCI-H524 NIPXVlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnu3TWM2OD12OD64NlQ5KM7:TR?= MULTRW5ITVJ?

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

体内試験 In vivo, Doxorubicin in combination with adenoviral MnSOD (AdMnSOD) plus 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) has the greatest effect in decreasing the volumes of MB231 tumors and prolonging survival of mice. [1] Although its use is limited by the chronic and acute toxic side effects it produces, Doxorubicin is essential in treating breast and oesophageal carcinomas, solid tumours in childhood, osteosarcomas, Kaposi's sarcoma, soft tissue sarcomas, and Hodgkin and non-Hodgkin lymphomas. [2]

お薦めの試験操作(参考用のみ)

動物試験:[1]
+ 展開
  • 動物モデル: Female athymic nude mice injected s.c. with MB231 cells
  • 製剤: Dissolved in DMSO, and diluted in saline
  • 投薬量: 3 mg/kg/day
  • 投与方法: Delivered intratumorly
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 100 mg/mL (172.41 mM) warming
Water 20 mg/mL (34.48 mM)
Ethanol Insoluble

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 579.98
化学式

C27H29NO11.HCl

CAS No. 25316-40-9
保管
in solvent
別名 NSC 123127

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03571321 Not yet recruiting Acute Lymphoblastic Leukemia|ALL Childhood|ALL Univers