Doxorubicin (Adriamycin) HCl

For research use only. Not for use in humans.

Licensed by Pfizer 製品コードS1208 別名:NSC 123127

Doxorubicin (Adriamycin) HCl化学構造

分子量(MW):579.98

Doxorubicin (Adriamycin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.

サイズ 価格(税別) 在庫  
10mM (1mL in DMSO) JPY 21400 あり
JPY 16900 あり
JPY 36800 あり
JPY 113200 あり
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製品安全説明書

Topoisomerase阻害剤の選択性比較

生物活性

製品説明 Doxorubicin (Adriamycin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.
ターゲット
Topo II [1]
(Tumor cells)
体外試験

Doxorubicin, an antibiotic anthracycline, is commonly considered to exert its anti-tumor activity at two fundamental levels, altering DNA and producing free radicals to trigger apoptosis of cancer cells through DNA damage. Doxorubicin can block the synthesis of DNA by intercalating into the DNA strand, and inhibits DNA topoisomerase II (TOP2). Doxorubicin is most effective when cells are rapidly proliferating and expressing high levels of TOP2. Additionally, Doxorubicin can trigger apoptosis by producing ceramide (which prompts apoptosis by activating p53 or other downstream pathways such as JNK), the degradation of Akt by serine threonine proteases, the mitochondrial release of cytochrome c, increased FasL (death receptor Fas/CD95 ligand) mRNA production, and a greater production of free radicals. [2] Pre-treatment with GSNO (nitrosoglutathione) suppresses the resistance in the doxorubicin-resistant breast cancer cell line MCF7/Dx, accompanied by enhanced protein glutathionylation and accumulation of doxorubicin in the nucleus. [3] Doxorubicin induced G2/M checkpoint arrest are attributed to elevated cyclin G2 (CycG2) expression and phospho-modification of proteins in the ataxia telangiectasia mutated (ATM) and ATM and Rad3-related (ATR) signaling pathways. [5] Doxorubicin inhibits AMP-activated protein kinase (AMPK), resulting in SIRT1 dysfunction, p53 accumulation, and increased cell death in mouse embryonic fibroblasts (MEFs) and cardiomyocytes, which can be further sensitized by pre-inhibition of AMPK. [6] Doxorubicin elicits a marked heat shock response, and that either inhibition or silencing of heat shock proteins enhance the Doxorubicin apoptotic effect in neuroblastoma cells. Nanomolar Doxorubicin treatment of neuroblastoma cells causes dose-dependent over-ubiquitination of a specific set of proteins in the absence of measurable inhibition of proteasome, and loss of activity of ubiquitinated enzymes such as lactate dehydrogenase and α-enolase, the protein ubiquination patterns of which is similar to those with proteasome inhibitor Bortezomib, indicating that Doxorubicin may also exert its effect by damaging proteins. [8]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
L1210 M{TiN2Z2dmO2aX;uJGF{e2G7 M{T4fGlvcGmkaYTpc44hd2ZiUl7BJJN6dnSqZYPpd{B4cXSqIFXEOVAhd2ZiMD61PEDPxE1? MoPEOFkxPTN4
Yoshida sarcoma NFPpfpVHfW6ldHnvckBCe3OjeR?= NX3IVpVrUW6qaXLpeIlwdiCxZjDbN2heXGSUIHnuZ49zeG:{YYTpc44hf2m2aDDJR|UxKG:oIECuNFIh|ryP NXS3UGNUOTN{Mkm4Oi=>
CHO NFPyUIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHHSVhJUUN3ME2wMlA3KM7:TR?= M1XsfVE{PTR5NUC=
8226 M1S5cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTXTWM2OD1yLkCzN{DPxE1? Mn;QNVQ1Pzd|MB?=
8226/ADR MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;BfWlEPTB;MD61OkDPxE1? Ml36NVQ1Pzd|MB?=
MCF7/ADR M2\LWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFL4S|RKSzVyPUOuNUDPxE1? MmLzNVQ1Pzd|MB?=
H69 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXPXnNLUUN3ME2wMlg4KM7:TR?= M3HlbVE1Pzl3OEW=
N417 Mmn3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjRSVRKSzVyPUCuNlMh|ryP MkPhNVQ4QTV6NR?=
H9 NYKx[XRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJcohq[mm2aX;uJI9nKEh7IHPlcIx{KGOqcn;ubYNidGy7IHnu[oVkfGWmIIfpeIghfGinIFjJWk0yKCiKOT;JTWlDMSC5aYToJGlFPTBib3[gNE4xOSEQvF2= M3HzdFE2PDh4OEG=
T-C8166 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDGSJZKTDVyPUCuNFEh|ryP MnL2NVU1QDZ6MR?=
T-H9 M{Hremdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLpTWQ2OD1yLkCxJO69VQ>? MlPRNVU1QDZ6MR?=
T-MT4 NHzNWlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofSTWQ2OD1yLkCxJO69VQ>? NVfxV5pnOTV2OE[4NS=>
SKMEL-5 NETP[IZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37FPWVFPTB;Mz6yJO69VQ>? MV6xOlE{PzV|
MLM MV;DfZRwfG:6aXOgRZN{[Xl? NYPlWIF2TUR3ME2wMlE{KM7:TR?= MXyxPFc2OzVy
KBM-3 NYXjNVR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnyTodKSzVyPUCuNFI3KM7:TR?= MkC5NVk6PTh5Nx?=
HT-29 NXvxO2xZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2H3PVAvODFizszn Ml;nOFghcA>? NInVXJRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fS=> Mon5Nlc4QDR2OR?=
EMT6 NYH1bVNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHpepcxNjVizszN MlX3NUBp MXzJcohq[mm2aX;uJI9nKHC{b3zp[oVz[XSrb36gZpkhdWWjc4XybY5oKG[xcjDzeZJ3cX[rbneg[pJi[3Srb37zJJdqfGhiRVS1NEBw\iByLkCwNFEh|ryP NVzX[ZA3PzR3Mk[3OC=>
H2981 MYfDfZRwfG:6aXOgRZN{[Xl? M4C3WWlEPTB;MD61JO69VQ>? MlLSO|c{OTB{Mx?=
LOX Mo\zR5l1d3SxeHnjJGF{e2G7 MkXuTWM2OD1yLkC0NkDPxE1? M2PBcVc5PTN|M{G=
C38 MVTDfZRwfG:6aXOgRZN{[Xl? MVPJR|UxRTBwMEGg{txO M{DUVVgxPTd{OUG=
EAC MUTDfZRwfG:6aXOgRZN{[Xl? MnzRO|IhcA>? NGHMZ|lKSzVyPUCuN|Uh|ryP NGftZ4U5OzVyMEi3
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AUC375 NI\SdYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LRfmlEPTB;MD6xNVIh|ryP MoG0PFY1QDZyMB?=
A2780-C25 MoCzR5l1d3SxeHnjJGF{e2G7 MljiR5l1d3SxeHnjbZR6KGGpYXnud5Qhd3ijbHnwcIF1cW5vcnXzbZN1[W62IFGyO|gxNUN{NTD3bZRpKEmFNUCgc4YhOC5yNkOg{txO MnG3PFg{OTd3NR?=
A2780-CP3 NVnMcJZES3m2b4TvfIlkKEG|c3H5 MknqR5l1d3SxeHnjbZR6KGGpYXnud5Qh[2m|cHzheIlvNXKnc3nzeIFvfCCDMke4NE1EWDNid3n0bEBKSzVyIH;mJFAvODV4IN88US=> NWLwUXJ7QDh|MUe1OS=>
A2780-DX5 NUHGT212S3m2b4TvfIlkKEG|c3H5 MY\DfZRwfG:6aXPpeJkh[WejaX7zeEBld3ixcoXibYNqdi2{ZYPpd5RidnRiQUK3PFAuTFh3IIfpeIghUUN3MDDv[kAxNjN3NzFOwG0> NHi3fpI5QDNzN{W1
MXF7 NInZW29EgXSxdH;4bYMhSXO|YYm= M2nRR2FvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JJNmdnOrdHn2[UBOYEZ5IIfpeIghUUN3MDDv[kAxNjB{ODFOwG0> MkjwPFk3ODV3OB?=
MXF7 MoG1R5l1d3SxeHnjJGF{e2G7 M3PJbmFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JI1qfG:6YX70do9v\S2{ZYPpd5RidnRiTWjGO{B4cXSqIFnDOVAhd2ZiMD6wNlgh|ryP NYTGblI4QDl4MEW1PC=>
MXF7 M2f0cWN6fG:2b4jpZ{BCe3OjeR?= M3jmRmFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIRwgG:{dXLpZ4lvNXKnc3nzeIFvfCCPWF[3JJdqfGhiSVO1NEBw\iBzLkG3NkDPxE1? MojVPFk3ODV3OB?=
WiDr Mn;tR5l1d3SxeHnjJGF{e2G7 NX\NWnhqSWO2aY\peJkh[WejaX7zeEB{\W6|aYTpeoUhX2mGcjDj[YxtKHerdHigTWM2OCCxZjCwMlA2OyEQvF2= M2\UOVg6PjB3NUi=
MCF MlfhSpVv[3Srb36gRZN{[Xl? NIrYbVJT\X[ncoPhcEBw\iCSLXfwMY1m\GmjdHXkJI12dHSrZIL1[{Bz\XOrc4ThcoNmKGG|c3Xzd4VlKGG|IHXubIFv[2WvZX70JIlvKGO7dH;0c5hq[2m2eTDv[kBi\HKrYX35Z4lv MX[4PVg1OTVz
C6 MYPDfZRwfG:6aXOgRZN{[Xl? M1niSVIvPSCvZz;tUC=> MlfKO|IhcA>? MVjEUXNQ MX;DfZRwfG:6aXPpeJkh[WejaX7zeEBz[XRiQ{[gZ4VtdHNiYYSgOVAhfWdxbVygeI8hOi53IH3nM41N MWG4PVg5PjB2
C6 M1zsR2Z2dmO2aX;uJGF{e2G7 MWWyMlUhdWdxbVy= MVS0JIg> MnfWSG1UVw>? NVfjS5dnUW6qaXLpeIlwdiCxZjD0eYJ2dGmwIIDvcJlu\XKrenH0bY9v MYK4PVg5PjB2
C6 M1nCRWN6fG:2b4jpZ{BCe3OjeR?= MV:yMlUhdWdxbVy= MUS1JIg> MX\EUXNQ Ml[xR5l1d3SxeHnjbZR6KGG|c3Xzd4VlKGG|IHPlcIwhemWuZXHz[S=> NG\NXW85QTh6NkC0
SKVLB Mn;hR5l1d3SxeHnjJGF{e2G7 MVi3NkBp M2fIWmlEPTB;Nj61OEDPxE1? NVfoe5RLQTByM{WyNC=>
MCF7/VP16 NXnocYlPS3m2b4TvfIlkKEG|c3H5 NVnsOnlpPTBizsznM41N MV:3NkBp NVrIZoFPUUN3ME2xOE4zKM7:TR?= M2PvbFkxOjJ5OUK=
CA755 NWL3cIJCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TnZ|ExKM7:TR?= NUfS[YNLPiCm NILyUZdKSzVyPUCuNFE1KM7:TR?= MYS5OVI3PTdy
CHO NXPsPFlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zYZ|ExKM7:TR?= MYO2JIQ> NVXST3A3UUN3ME2wMlA3KM7:TR?= M2nVOFk2OjZ3N{C=
Panc02 NVi0fopuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PEfFExKM7:TR?= Ml\GOkBl M1fzbmlEPTB;MD6wOlUh|ryP MVu5OVI3PTdy
PC14 M3\1dWN6fG:2b4jpZ{BCe3OjeR?= MlzWOEBl NWPsfWI{TE2VTx?= M3K0S2lEPTB;MD6yPUDPxE1? MlfhPVgzOjV2Mh?=
HOP62 MXLDfZRwfG:6aXOgRZN{[Xl? MWS3NkBp M2fIcmlEPTB;MD6wNFQh|ryP MmrlPVg4OzZ4MR?=
SF-295 NYezPJdpS3m2b4TvfIlkKEG|c3H5 MXW3NkBp NHmzT3hKSzVyPUCuNFM2KM7:TR?= NH24NVc6QDd|Nk[x
MDA-MB-361 MknTR5l1d3SxeHnjJGF{e2G7 NFS3UGkyKGh? MnjOSG1UVw>? M{K3SGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2GQT3NRk0{PjFiZYjwdoV{e2mwZzDMZYNbKHerdHigTWM2OCCxZjCwMlAyOiEQvF2= MWOxNFM6PTR7MB?=
MDA-MB-361 M{jaXmN6fG:2b4jpZ{BCe3OjeR?= NYPDWpVKOSCq Mn64SG1UVw>? M1PkUWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2GQTDNRkA{PjFiZYjwdoV{e2mwZzDjZZJjd3i7cHXweIll[XOnIIP0R3BIOiC5aYToJGlEPTBib3[gNE4xOThizszN MnvuNVA{QTV2OUC=
CCRF-SB NF;LVXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXe0JIQ> MWLEUXNQ M3XUOWlEPTB;MD6wNUDPxE1? NWfSdmZxOTB2MUG0O|Y>
CHO-K1 Mn3aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYC0JIQ> M1jzVGROW09? NH;v[GNKSzVyPUCuOEDPxE1? NFLNeXgyODRzMUS3Oi=>
KB MnXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljlOEBl M4DSS2ROW09? MkjlRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDkdpVoNXKnc3nzeIFvfCCNQkfEJJdqfGhiSVO1NEBw\iByLk[1JO69VQ>? MojONVA1OTF2N{[=
KB M3n3cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{X0W|Qh\A>? MlPzSG1UVw>? MVnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHTyeYcuemW|aYP0ZY51KEuEQ3HtdJdqfGhiSVO1NEBw\iByLkC2JO69VQ>? NHjlOIMyODRzMUS3Oi=>
KB NYnVZ|ZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWW0JIQ> NGjLUpRFVVOR MXfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHTyeYcuemW|aYP0ZY51KEuETVTSJJdqfGhiSVO1NEBw\iByLkWg{txO NIDvUXcyODRzMUS3Oi=>
KB NF3HOJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLLOEBl NEK5[4xFVVOR M2DUVGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4Sg[JJ2\y2{ZYPpd5RidnRiS1LWNlBEKHerdHigTWM2OCCxZjCwMlQh|ryP MVOxNFQyOTR5Nh?=
HTB-54 M2LHUWN6fG:2b4jpZ{BCe3OjeR?= NU\rSWRoOTByIN88US=> NYLUfppOUUN3ME2xMlEh|ryP MXSxNFQ4Pjh4MR?=
MEL-AC NFfNVIlEgXSxdH;4bYMhSXO|YYm= M1G4cVExOCEQvF2= MV;JR|UxRTFwMjFOwG0> M1rjeFExPDd4OE[x
DU145 M1O0NGN6fG:2b4jpZ{BCe3OjeR?= NXnjcZBbPzJiaB?= MYHJR|UxRTBwMEWyPEDPxE1? NI\TTGoyODR5OUK4Ni=>
K562R NEnoT2tEgXSxdH;4bYMhSXO|YYm= NVr3WJlZPzJiaB?= M{H6RWlEPTB;MD6wNVU3KM7:TR?= M2rZTlExPDd7Mkiy
PACA-2 Ml\ER5l1d3SxeHnjJGF{e2G7 NE\rXIM3KGR? MVLFSFUxRTBwMEC2N{DPxE1? NYK2NJQ4OTB2OUiyNVQ>
3Y1 MXTDfZRwfG:6aXOgRZN{[Xl? M4XZPFczKGh? NV;lWHJQT0l3ME2wMlAxOzhizszN NFi5UHIyODZ7MUexNC=>
P388 MYDDfZRwfG:6aXOgRZN{[Xl? MW[3NkBp NE[4XnRIUTVyPUCuNFEzKM7:TR?= M3fDdVExPjlzN{Gw
HMV-1 NH3wS21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfWVmtKSzVyPUCuNlgh|ryP MnXkNVA3QTh2M{[=
MKN-1 NIHvWXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moj4TWM2OD1yLk[0JO69VQ>? MWCxNFY6QDR|Nh?=
PC14 NHvUe2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHz0OXJKSzVyPUGuPUDPxE1? NVPLRm9WOTB4OUi0N|Y>
T24 MlLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLhW2dKSzVyPUCuOlQh|ryP NX7HSlNsOTB4OUi0N|Y>
U937 MWXGeY5kfGmxbjDBd5NigQ>? NYT0R2NpOjRiaB?= NF6ydZJFVVOR MV\Jcohq[mm2czDpcoNwenCxcnH0bY9vKG:oIGuzTH11cHmvaXTpcoUhf2m2aDDJR|UxKG:oIECuNUDPxE1? MXKxNFc5ODlzMR?=
H460pv8/eto NEnKXVlEgXSxdH;4bYMhSXO|YYm= NHnCVFMyODBizszN NEXL[pI1QCCq MXXTZYxqdmV? NHy4Wm5KSzVyPUCuNFIh|ryP NXj0[486OTB5OEC5NVM>
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MDA-231 M3TzVmN6fG:2b4jpZ{BCe3OjeR?= NVS4UG5YOTByIN88US=> MkP6OFghcA>? NEHZS5RU[WyrbnW= MnTsR5l1d3SxeHnjbZR6KGGpYXnud5QhVUSDLUKzNUBk\WyuIDjFVk0tTUeIUjuscZV1[W62IIC1N{khf2m2aDDJR|UxKG:oIECuNFA3KM7:TR?= M2S2blExPzhyOUGz
MDA-468 NYPmWXFPS3m2b4TvfIlkKEG|c3H5 NIXLcnYyODBizszN MmXIOFghcA>? MWLTZYxqdmV? NHvrdopEgXSxdH;4bYNqfHliYXfhbY5{fCCPRFGtOFY5KGOnbHygLGVTNSxiYX3wcIlncWWmIFXHSnItKG23dHHueEBxPTNrIIfpeIghUUN3MDDv[kAxNjByNTFOwG0> NVr5OpdbOTB5OEC5NVM>
NCI-H226 M{\EfmN6fG:2b4jpZ{BCe3OjeR?= MofkNVAxKM7:TR?= NYK5OG5bPDhiaB?= MkDkV4FtcW6n MXXDfZRwfG:6aXPpeJkh[WejaX7zeEBPS0lvSEKyOkBk\WyuIDjteZRidnRicEWzLUB4cXSqIFnDOVAhd2ZiMD6wNFgh|ryP NIq4VogyODd6MEmxNy=>
NCI-H322 Mn7tR5l1d3SxeHnjJGF{e2G7 M1fZXFExOCEQvF2= MXu0PEBp M2X4WnNidGmwZR?= NGXtdWZEgXSxdH;4bYNqfHliYXfhbY5{fCCQQ1mtTFMzOiClZXzsJEhufXSjboSgdFU{MSC5aYToJGlEPTBib3[gNE4xOyEQvF2= NXP5SoRuOTB5OEC5NVM>
NCI-H358 MWDDfZRwfG:6aXOgRZN{[Xl? NXPTbYUzOTByIN88US=> MVe0PEBp MVnTZYxqdmV? NFHyS5FEgXSxdH;4bYNqfHliYXfhbY5{fCCQQ1mtTFM2QCClZXzsJEhufXSjboSgdFU{MSC5aYToJGlEPTBib3[gNE4yOyEQvF2= MmnBNVA4QDB7MUO=
NCI-H647 MkXuR5l1d3SxeHnjJGF{e2G7 M1jFRVExOCEQvF2= Ml3vOFghcA>? NGWwVYhU[WyrbnW= M{\He2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KE6FST3IOlQ4KGOnbHygLI12fGGwdDDwOVMqKHerdHigTWM2OCCxZjCwMlAxOSEQvF2= NHrFOGIyODd6MEmxNy=>
SKBR-3 M{XVW2N6fG:2b4jpZ{BCe3OjeR?= NVno[2FwOTByIN88US=> MmTJOFghcA>? MYDTZYxqdmV? MkDrR5l1d3SxeHnjbZR6KGGpYXnud5QhW0uEUj2zJINmdGxiKFXSMYFueGyrZnnl[EBmekJ{LH31eIFvfCCyNUOpJJdqfGhiSVO1NEBw\iByLkCyJO69VQ>? NFztWI4yODd6MEmxNy=>
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L1210 M4TONWN6fG:2b4jpZ{BCe3OjeR?= M{PHZ2lEPTB;MD6wNlUh|ryP MoKwNVA5QTBzNke=
D40 MmLIR5l1d3SxeHnjJGF{e2G7 NEizTVkzPCCq MkHZSG1UVw>? NVq0S2VEUUN3ME2xMlE4OiEQvF2= MXixNFk2PjJzNB?=
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