AMPK

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S7306 Dorsomorphin (Compound C) 2HCl 94 mg/mL <1 mg/mL <1 mg/mL
S7317 WZ4003 <1 mg/mL 7 mg/mL <1 mg/mL
S7318 HTH-01-015 <1 mg/mL 58 mg/mL 30 mg/mL
S7840 Dorsomorphin (Compound C, BML-275) <1 mg/mL 1 mg/mL 2 mg/mL
S1802 AICAR (Acadesine) <1 mg/mL 51 mg/mL <1 mg/mL
S2542 Phenformin HCl 48 mg/mL 48 mg/mL 12 mg/mL
S5284 Adenosine 5'-monophosphate monohydrate -1 mg/mL 9 mg/mL -1 mg/mL
S8803 MK-3903 <1 mg/mL 91 mg/mL <1 mg/mL
S8654 ex229 (compound 991) <1 mg/mL 12 mg/mL <1 mg/mL
S8335 PF-06409577 <1 mg/mL 68 mg/mL 68 mg/mL
S7898 GSK621 <1 mg/mL 97 mg/mL <1 mg/mL
S9096 ligustroflavone -1 mg/mL 100 mg/mL -1 mg/mL
S7953 ETC-1002 <1 mg/mL 68 mg/mL <1 mg/mL

AMPK製品

新AMPK製品
製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S7306

Dorsomorphin (Compound C) 2HCl

Dorsomorphin 2HCl is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Also inhibits type Ⅰ BMP receptor activity.

S7317

WZ4003

WZ4003 is a highly specific NUAK kinase inhibitor with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2 in cell-base assays, respectively, without significant inhibition on 139 other kinases.

S7318

HTH-01-015

HTH-01-015 is a potent and selective NUAK1 inhibitor with IC50 of 100 nM, >100-fold selectivity over NUAK2.

S7840

Dorsomorphin (Compound C, BML-275)

Dorsomorphin is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Also inhibits type I BMP receptor activity.

S1802

AICAR (Acadesine)

AICAR (Acadesine), an AMPK activator, results in accumulation of ZMP, which mimics the stimulating effect of AMP on AMPK and AMPK kinase. Phase 3.

S2542

Phenformin HCl

Phenformin HCl is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class. It activates AMPK, increasing activity and phosphorylation.

S5284

Adenosine 5'-monophosphate monohydrate

Adenosine 5'-monophosphate monohydrate (5'-AMP) is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK).

S8803

MK-3903

MK-3903 is a potent and selective AMPK activator with an EC50 of 8 nM for α1 β1 γ1 subunit. It activates 10 of the 12 pAMPK complexes with EC50 values in the range of 8-40 nM and maximal activation >50%.

S8654

ex229 (compound 991)

EX229 (compound 991) is a potent AMPK activator that is 5-10-fold more potent than A769662 in activating AMPK.

S8335

PF-06409577

PF-06409577 is orally bioavailable AMPK activator with EC50 of 7 nM for α1β1γ1 in the TR-FRET assay and it shows no detectable inhibition of hERG in a patch-clamp assay (100 μM) and was not an inhibitor (IC50 > 100 μM) of the microsomal activities of major human cytochrome P450 isoforms.

S7898

GSK621

GSK621 is a specific and potent AMPK activator.

S9096

ligustroflavone

Ligustroflavone, isolated from the leaves of Turpinia montana, shows high antioxidant capacity and is reported to be an AMPK activator.

S7953

ETC-1002

ETC-1002,also known as Bempedoic acid, is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies.ETC-1002 is an activator of hepatic AMP-activated protein kinase (AMPK). It has potent inhibitory activity against hepatic ATP-citrate lyase(IC50=29 uM).

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S7306

Dorsomorphin (Compound C) 2HCl

Dorsomorphin 2HCl is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Also inhibits type Ⅰ BMP receptor activity.

S7317

WZ4003

WZ4003 is a highly specific NUAK kinase inhibitor with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2 in cell-base assays, respectively, without significant inhibition on 139 other kinases.

S7318

HTH-01-015

HTH-01-015 is a potent and selective NUAK1 inhibitor with IC50 of 100 nM, >100-fold selectivity over NUAK2.

S7840

Dorsomorphin (Compound C, BML-275)

Dorsomorphin is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Also inhibits type I BMP receptor activity.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1802

AICAR (Acadesine)

AICAR (Acadesine), an AMPK activator, results in accumulation of ZMP, which mimics the stimulating effect of AMP on AMPK and AMPK kinase. Phase 3.

2019, 27(12):3413-3421

2019, 38(1):192

2019, 1865(6):1701-1712

S2542

Phenformin HCl

Phenformin HCl is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class. It activates AMPK, increasing activity and phosphorylation.

2019, 178(5):1102-1114

2019, 10(1):3856

2017, 292(7):2830-2841

S5284

Adenosine 5'-monophosphate monohydrate

Adenosine 5'-monophosphate monohydrate (5'-AMP) is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK).

S8803

MK-3903

MK-3903 is a potent and selective AMPK activator with an EC50 of 8 nM for α1 β1 γ1 subunit. It activates 10 of the 12 pAMPK complexes with EC50 values in the range of 8-40 nM and maximal activation >50%.

S8654

ex229 (compound 991)

EX229 (compound 991) is a potent AMPK activator that is 5-10-fold more potent than A769662 in activating AMPK.

S8335

PF-06409577

PF-06409577 is orally bioavailable AMPK activator with EC50 of 7 nM for α1β1γ1 in the TR-FRET assay and it shows no detectable inhibition of hERG in a patch-clamp assay (100 μM) and was not an inhibitor (IC50 > 100 μM) of the microsomal activities of major human cytochrome P450 isoforms.

S7898

GSK621

GSK621 is a specific and potent AMPK activator.

2019, 10(3):221

2019, 26(13):3613-3628

2018, 17(1):1998-2004

S9096

ligustroflavone

Ligustroflavone, isolated from the leaves of Turpinia montana, shows high antioxidant capacity and is reported to be an AMPK activator.

S7953

ETC-1002

ETC-1002,also known as Bempedoic acid, is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies.ETC-1002 is an activator of hepatic AMP-activated protein kinase (AMPK). It has potent inhibitory activity against hepatic ATP-citrate lyase(IC50=29 uM).

Tags: AMPK inhibition | AMPK activation | AMPK phosphorylation | AMPK activity | AMP-activated protein kinase pathway | AMPK activity assay | AMPK activators review | AMPK activity assay | AMPK inhibitor cancer | AMPK agonists | AMPK antagonist | AMPK inhibitor review