Paclitaxel (NSC 125973)

For research use only. Not for use in humans.

製品コードS1150 別名:PTX, Taxol, Onxal, Abraxane

Paclitaxel (NSC 125973)化学構造

CAS No. 33069-62-4

Paclitaxel (NSC 125973, PTX, Taxol, Onxal, Abraxane) is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.

サイズ 価格(税別)  
10mM (1mL in DMSO) JPY 17100
JPY 13600
JPY 46800
JPY 69700
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バルク問合せ

文献中Selleckの製品使用例(336)

製品安全説明書

Antineoplastic and Immunosuppressive Antibiotics阻害剤の選択性比較

生物活性

製品説明 Paclitaxel (NSC 125973, PTX, Taxol, Onxal, Abraxane) is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.
ターゲット
Microtubule (human endothelial cells) [1]
0.1 pM
体外試験

Paclitaxel inhibits non-endothelial type human cells at 104 - to 105 -fold higher concentrations, with IC50 of 1 nM-10 nM. The selectivity of Paclitaxel inhibition of cell proliferation is also species specific, as mouse ECs are not sensitive to Paclitaxel at ultra low concentrations. Inhibition of human ECs by Paclitaxel at ultra low concentrations does not affect the cellular microtubule structure, and the treated cells do not show G2/M cell cycle arrest and apoptosis, suggesting a novel but as yet unidentified mechanism of action. In an in vitro angiogenesis assay, Paclitaxel at ultra low concentrations blocks human ECs from forming sprouts and tubes in the three-dimensional fibrin matrix. [1] In the presence of SMF, the efficient concentration of Paclitaxel on K562 cells is decreased from 50 to 10 ng/mL. The cell cycle arrest effect of Paclitaxel with or without SMF on K562 cells is correlated with DNA damage. [2] Paclitaxel alone causes a time-dependent inhibition of CDK1 in four cell lines including A549 cells, H358, H1395 cells and H1666 cells. [3]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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NB14 M2DnV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzCR5JKSzVyIE2gO{45OTN7IN88US=> M{LVTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQzQDZ2Nz:nQnNCVkeHUkyvZV4>
ES5 NILwN4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4H0eWlEPTBiPTC3Mlg3PjZ{IN88US=> M17Rc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQzQDZ2Nz:nQnNCVkeHUkyvZV4>
SK-MEL-2 NH;ROlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxKD1iOD60OVk4PiEQvF2= Mm\RQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI5PjR5Lze+V2FPT0WUPD;hQi=>
COLO-800 NXLJeYFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jQd2lEPTBiPTC4MlQ4QDdizszN NUfiUJFORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDJ6NkS3M{c,W0GQR1XSQE9iRg>?
EB2 NHvGbWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxKD1iOT6xPVg{PSEQvF2= MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0Nlg3PDdxJ{7TRW5ITVJ:L3G+
ES3 NWrNSJg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxKD1iOT6zNFY3PSEQvF2= M4jwTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQzQDZ2Nz:nQnNCVkeHUkyvZV4>
SKM-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2S3U2lEPTBiPTC5MlM6PDV7IN88US=> MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0Nlg3PDdxJ{7TRW5ITVJ:L3G+
MFM-223 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPKbpFKSzVyIE2gPU42ODF{NzFOwG0> Mn\XQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI5PjR5Lze+V2FPT0WUPD;hQi=>
LB2241-RCC NVXBfZlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jkR2lEPTBiPTCxNE4xOzh4IN88US=> MorkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI5PjR5Lze+V2FPT0WUPD;hQi=>
EW-13 NHLjboxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LPV2lEPTBiPTCxNE4{OzN|IN88US=> Mk\VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI5PjR5Lze+V2FPT0WUPD;hQi=>
D-283MED MkDpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDT[GpYUUN3MDC9JFExNjR7NUmg{txO MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0Nlg3PDdxJ{7TRW5ITVJ:L3G+
EW-11 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDFWZpKSzVyIE2gNVEvPjZ7NDFOwG0> NXHjSYxVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDJ6NkS3M{c,W0GQR1XSQE9iRg>?
NCI-H128 NUHRcWJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxKD1iMUKuNVM{PCEQvF2= MoHHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI5PjR5Lze+V2FPT0WUPD;hQi=>
ES7 NGHqUnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnHPWxKSzVyIE2gNVUvOjR7NDFOwG0> Mn\TQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI5PjR5Lze+V2FPT0WUPD;hQi=>
AM-38 M1XwZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vYcWlEPTBiPTCxOU41OTZ4IN88US=> MlnSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI5PjR5Lze+V2FPT0WUPD;hQi=>
NCI-H716 MkfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jKN2lEPTBiPTCxO{46Ojl7IN88US=> MnLEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI5PjR5Lze+V2FPT0WUPD;hQi=>
NCI-H1770 NHzFNFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYGyS3diUUN3MDC9JFE5NjN6NUGg{txO M3XBblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQzQDZ2Nz:nQnNCVkeHUkyvZV4>
JVM-3 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrzdYxKSzVyIE2gNlAvQDl6NTFOwG0> Moi5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI5PjR5Lze+V2FPT0WUPD;hQi=>
CW-2 NVvMR3hlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fHU2lEPTBiPTCyNU4yOzR7IN88US=> NXXsUW8xRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDJ6NkS3M{c,W0GQR1XSQE9iRg>?
YT NHfJN4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXriSo5qUUN3MDC9JFIyNjR4OUGg{txO Ml;QQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI5PjR5Lze+V2FPT0WUPD;hQi=>
C8166 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxKD1iMkKuNlc1PiEQvF2= MmTFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI5PjR5Lze+V2FPT0WUPD;hQi=>
SUP-T1 NETpXodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnPVWxKSzVyIE2gNlMvOjVzMjFOwG0> MkXzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI5PjR5Lze+V2FPT0WUPD;hQi=>
KASUMI-1 NH\RRnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV2xcGZFUUN3MDC9JFI{NjVzMUmg{txO NEWxVY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1Ojh4NEevK|5USU6JRWK8M4E,
IM-9 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYraN3dMUUN3MDC9JFI{NjZ7N{mg{txO MnHlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI5PjR5Lze+V2FPT0WUPD;hQi=>
NH-12 NIDwTpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfHZ4RKSzVyIE2gNlQvOTZ3NDFOwG0> MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0Nlg3PDdxJ{7TRW5ITVJ:L3G+
WSU-NHL NE\K[JRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfPV5psUUN3MDC9JFI2Njd{NkGg{txO M3G5UFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQzQDZ2Nz:nQnNCVkeHUkyvZV4>
TUR MonqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2qzUWlEPTBiPTCyOk43PTN|IN88US=> MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0Nlg3PDdxJ{7TRW5ITVJ:L3G+
RL NXfRdYNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjlUY03UUN3MDC9JFI4NjJ{NEKg{txO M4Kx[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQzQDZ2Nz:nQnNCVkeHUkyvZV4>
EW-12 NFLremdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;QTWM2OCB;IEK4MlA4ODJizszN M2\YRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQzQDZ2Nz:nQnNCVkeHUkyvZV4>
KG-1 NVHjOYxqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rkNGlEPTBiPTCyPE4zQDZ3IN88US=> Ml33QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI5PjR5Lze+V2FPT0WUPD;hQi=>
P31-FUJ MmDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1SycmlEPTBiPTCyPU4xPDh7IN88US=> M33J[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQzQDZ2Nz:nQnNCVkeHUkyvZV4>
NB10 NVzSdpV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvROYpKSzVyIE2gN|EvPTB7IN88US=> NVvB[nNvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDJ6NkS3M{c,W0GQR1XSQE9iRg>?
COLO205 MUnDfZRwfG:6aXPpeJkh[XO|YYm= MWnHTVUxKD1iMD6wNFE4PiEQvF2= NIfxVmI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi95OUC4PVUxLz55OUC4PVUxRC:jPh?=
SF539 MWnDfZRwfG:6aXPpeJkh[XO|YYm= MYXHTVUxKD1iMD6wNFM3PiEQvF2= NH3ZTVM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi95OUC4PVUxLz55OUC4PVUxRC:jPh?=
SNB75 NYXVU4VVS3m2b4TvfIlkcXS7IHHzd4F6 M{PrTmdKPTBiPTCwMlAxQDB6IN88US=> NH\USoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi95OUC4PVUxLz55OUC4PVUxRC:jPh?=
DMS114 NHf5dFNEgXSxdH;4bYNqfHliYYPzZZk> NELIWpBIUTVyIE2gNE4xOTJ|IN88US=> NIDSOlQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi95OUC4PVUxLz55OUC4PVUxRC:jPh?=
OVCAR-3 NFfqU|NEgXSxdH;4bYNqfHliYYPzZZk> MWnHTVUxKD1iMD6wNVk4KM7:TR?= MoTLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwPzlyOEm1NEc,PzlyOEm1NFww[T5?
NCI-H460 NHfuOpVEgXSxdH;4bYNqfHliYYPzZZk> MVTHTVUxKD1iMD6wNlE6KM7:TR?= MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84QTB6OUWwK|44QTB6OUWwQE9iRg>?
HOP62 M{nJPGN6fG:2b4jpZ4l1gSCjc4PhfS=> NXTnPHJMT0l3MDC9JFAvODZ5MTFOwG0> NHLxRWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi95OUC4PVUxLz55OUC4PVUxRC:jPh?=
mammary carcinoma MYXDfZRwfG:6aXPpeJkh[XO|YYm= MUPJR|UxKD1iMD6yPVkh|ryP MmPMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQDF6Mk[5PEc,QDF6Mk[5PFww[T5?
NCI60 NWLYNFlsS3m2b4TvfIlkcXS7IHHzd4F6 NEH4[IVIUTVyIE2gNE4xODB4NTFOwG0> MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86PDZzNkWzK|46PDZzNkWzQE9iRg>?
MCF-7 MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mm\0S2k2OCB;IECuNFAyOSEQvF2= MmPYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTh5M{W5O{c,QTh5M{W5O|ww[T5?
murine leukemic P388 NYf3enV7T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnzYS2k2OCB;IECuNFE3KM7:TR?= NIj1PXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi97OEezOVk4Lz57OEezOVk4RC:jPh?=
KB M{jlPWN6fG:2b4jpZ4l1gSCjc4PhfS=> NY\wV|NSUUN3MDC9JFAvODB4IN88US=> Mlf6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB7N{iyNFAoRjFyOUe4NlAxRC:jPh?=
MCF7 M37MSGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MkLRO|IhcA>? NFnQdZlKSzVyIE2gNE4xODJizszN Mn\OQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF|MkWyNlYoRjFzM{K1NlI3RC:jPh?=
MCF-7 NWDGO2pTS3m2b4TvfIlkcXS7IHHzd4F6 Ml\4SWQ2OCB;IECuNFA1KM7:TR?= NI\aR2Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUOzOFU3Pyd-MUGzN|Q2Pjd:L3G+
uterine sarcoma (MES-SA) MX\DfZRwfG:6aXPpeJkh[XO|YYm= Mn\2TWM2OCB;IECuNFAxODRizszN NYnSTYZERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG3NlgyQTFpPkGxO|I5OTlzPD;hQi=>
nonsmall cell lung carcinoma (NCI-H460) NWL0d2hDS3m2b4TvfIlkcXS7IHHzd4F6 NXPib|lXUUN3MDC9JFAvODByMUSg{txO NGrHRW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUeyPFE6OSd-MUG3NlgyQTF:L3G+
colon adenocarcinoma (HT-29) M2\IOmN6fG:2b4jpZ4l1gSCjc4PhfS=> MYDJR|UxKD1iMD6wNFAyPiEQvF2= MlzvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF5MkixPVEoRjFzN{K4NVkyRC:jPh?=
prostate carcinoma (DU-145) MkHKR5l1d3SxeHnjbZR6KGG|c3H5 NILjVIpKSzVyIE2gNE4xODR6OTFOwG0> M{\SelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzN{K4NVkyLz5zMUeyPFE6OTxxYU6=
SW626 MoLrR5l1d3SxeHnjbZR6KGG|c3H5 NGnu[2k4OiCq NUnobnIyUUN3MDC9JFAvODByMEGg{txO Mm\pQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJyOEi0NlUoRjF{MEi4OFI2RC:jPh?=
Lu1 NYXLSIFjS3m2b4TvfIlkcXS7IHHzd4F6 MYC3NkBp MmrxTWM2OCB;IECuNFEh|ryP NXjvb2RWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUKwPFg1OjVpPkGyNFg5PDJ3PD;hQi=>
MCF7 M1XtPWN6fG:2b4jpZ4l1gSCjc4PhfS=> NVfFT3dlPzJiaB?= MkLtTWM2OCB;IECuNFIh|ryP MkjDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJyOEi0NlUoRjF{MEi4OFI2RC:jPh?=
P388 MVrDfZRwfG:6aXPpeJkh[XO|YYm= Mn;0O|IhcA>? MXfJR|UxKD1iMD6wNkDPxE1? MkS4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJyOEi0NlUoRjF{MEi4OFI2RC:jPh?=
LNCAP MmLJR5l1d3SxeHnjbZR6KGG|c3H5 Mly1O|IhcA>? M2HnSGlEPTBiPTCwMlAzKM7:TR?= Mn[5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJyOEi0NlUoRjF{MEi4OFI2RC:jPh?=
KB M372PWN6fG:2b4jpZ4l1gSCjc4PhfS=> NUjjNmpsPzJiaB?= NYrY[HNNUUN3MDC9JFAvODJizszN M1e0b|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{MEi4OFI2Lz5zMkC4PFQzPTxxYU6=
Col2 Mk[2R5l1d3SxeHnjbZR6KGG|c3H5 NFP5eHE4OiCq NU\ZO|ZtUUN3MDC9JFAvODJizszN MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjB6OESyOUc,OTJyOEi0NlU9N2F-
BC1 MV3DfZRwfG:6aXPpeJkh[XO|YYm= Mme5O|IhcA>? M{XNWWlEPTBiPTCwMlAzKM7:TR?= MnPDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJyOEi0NlUoRjF{MEi4OFI2RC:jPh?=
SK-MEL-2 M4XxRWN6fG:2b4jpZ4l1gSCjc4PhfS=> NYHlWnFCPzJiaB?= MmnvTWM2OCB;IECuNFch|ryP NHnZOXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkC4PFQzPSd-MUKwPFg1OjV:L3G+
L2987 MUDDfZRwfG:6aXPpeJkh[XO|YYm= M3jybmlEPTBiPTCwMlIh|ryP M3fXdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{NESzO|g{Lz5zMkS0N|c5OzxxYU6=
colon adenocarcinoma RKO NYjucIF4S3m2b4TvfIlkcXS7IHHzd4F6 NYn0PXo2UUN3MDC9JFAvODFizszN M1S3V|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{OEWyO|Y5Lz5zMki1Nlc3QDxxYU6=
NCI-H460 MXzDfZRwfG:6aXPpeJkh[XO|YYm= NETJSWU1QCCq NF23UnlKSzVyIE2gNE4xODl3IN88US=> M1LsRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF2Nkm1O|k5Lz5zNE[5OVc6QDxxYU6=
MCF7 MnnSR5l1d3SxeHnjbZR6KGG|c3H5 NVvIeIF2PDhiaB?= MnfCTWM2OCB;IECuNFEyOiEQvF2= NHTYcnA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNE[5OVc6QCd-MUS2PVU4QTh:L3G+
SF268 MV;DfZRwfG:6aXPpeJkh[XO|YYm= M{PTSFQ5KGh? NUDIbppDUUN3MDC9JFAvODJzNzFOwG0> NW\XZ5RJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUS2PVU4QThpPkG0Olk2Pzl6PD;hQi=>
MDA-MB-231 MnvYR5l1d3SxeHnjbZR6KGG|c3H5 Ml;NOFghcA>? NXrGO2N{UUN3MDC9JFAvODB2NTFOwG0> Mny1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTR7OEewOVEoRjF2OUi3NFUyRC:jPh?=
MCF7 NX3xdZBJS3m2b4TvfIlkcXS7IHHzd4F6 NVfpW4o{PDhiaB?= MXLJR|UxKD1iMD6wNFQ6KM7:TR?= M3rifVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF2OUi3NFUyLz5zNEm4O|A2OTxxYU6=
A2780 MljoR5l1d3SxeHnjbZR6KGG|c3H5 MVS0PEBp NIDR[XJKSzVyIE2gNE4xOjVizszN MoS5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTR7OEewOVEoRjF2OUi3NFUyRC:jPh?=
PC3 NF\zNHpEgXSxdH;4bYNqfHliYYPzZZk> MWe0PEBp NWXUXW9OUUN3MDC9JFAvODd5IN88US=> Mn3rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTR7OEewOVEoRjF2OUi3NFUyRC:jPh?=
MCF7 M4POfmN6fG:2b4jpZ4l1gSCjc4PhfS=> M1foSVczKGh? MXPJR|UxKD1iMD6wNFE1KM7:TR?= NXvXb|U3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUS5PFcxPTZpPkG0PVg4ODV4PD;hQi=>
multidrug-resistant MCF7 MUXDfZRwfG:6aXPpeJkh[XO|YYm= NEPhSGM4OiCq M1nmb2lEPTBiPTCwMlM2PCEQvF2= MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDl6N{C1Okc,OTR7OEewOVY9N2F-
PC3 NXTDdVI4S3m2b4TvfIlkcXS7IHHzd4F6 NYj0RYJSPDhiaB?= MkO1TWM2OCB;IECuNFE3KM7:TR?= NG[ybWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUC0N|QxOid-MUWwOFM1ODJ:L3G+
Hep3B Mm\ER5l1d3SxeHnjbZR6KGG|c3H5 NVf0SWlCPDhiaB?= MWrJR|UxKD1iMD6wN|Eh|ryP MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTB2M{SwNkc,OTVyNEO0NFI9N2F-
NCI-H460 Mn;LR5l1d3SxeHnjbZR6KGG|c3H5 MWS0PEBp MmnDTWM2OCB;IECuNFA6PSEQvF2= NIfyVms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUC0N|QxPCd-MUWwOFM1ODR:L3G+
MCF7 NXvlPI1TS3m2b4TvfIlkcXS7IHHzd4F6 MlLsOFghcA>? NEXCeWZKSzVyIE2gNE4xOTF{IN88US=> NFPiXYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUC0N|QxPCd-MUWwOFM1ODR:L3G+
SF268 NVvyNnFCS3m2b4TvfIlkcXS7IHHzd4F6 NXnMO|dXPDhiaB?= M3TqWWlEPTBiPTCwMlAzOTdizszN M4fzZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MESzOFA1Lz5zNUC0N|QxPDxxYU6=
KB MUDDfZRwfG:6aXPpeJkh[XO|YYm= MmroSWQ2OCB;IECuNFAxPCEQvF2= NV7ERXpoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWwOFM1ODdpPkG1NFQ{PDB5PD;hQi=>
Lu1 MV7DfZRwfG:6aXPpeJkh[XO|YYm= MWLFSFUxKD1iMD6wNFIh|ryP NV62NFZtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWwOFM1ODdpPkG1NFQ{PDB5PD;hQi=>
LNCAP NY[zOnJCS3m2b4TvfIlkcXS7IHHzd4F6 NYruVppuTUR3MDC9JFAvODB3IN88US=> MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTB2M{SwO{c,OTVyNEO0NFc9N2F-
RPE1 Mlf5R5l1d3SxeHnjbZR6KGG|c3H5 Mk[2SWQ2OCB;IECuNFI{KM7:TR?= MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTB2M{SwO{c,OTVyNEO0NFc9N2F-
Col2 MlTqR5l1d3SxeHnjbZR6KGG|c3H5 MUfFSFUxKD1iMD6wOFYh|ryP MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTB2M{SwO{c,OTVyNEO0NFc9N2F-
T47D M2LFWGFxd3C2b4Ppd{Bie3OjeR?= M3X1clI1KGh? MkL0SWM2OCB;IECuNFMh|ryP MoCzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV3Nk[zNFAoRjF3NU[2N|AxRC:jPh?=
DLD1 MmLVRZBweHSxc3nzJIF{e2G7 NUTCVpdiOjRiaB?= M4rQPGVEPTBiPTCwMlA4PSEQvF2= M{\HflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NU[2N|AxLz5zNUW2OlMxODxxYU6=
H1299 NVjJfolOSXCxcITvd4l{KGG|c3H5 NUDiRXdOOjRiaB?= M2fEeGVEPTBiPTCwMlE3OyEQvF2= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTV4NkOwNEc,OTV3Nk[zNFA9N2F-
VA13 NIX5SVVEgXSxdH;4bYNqfHliYYPzZZk> M1e0dVQ5KGh? NWjHPWpUUUN3MDC9JFAvODB3IN88US=> M4S0OFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3N{OwNlQ{Lz5zNUezNFI1OzxxYU6=
WI 38 NXHSVWxHS3m2b4TvfIlkcXS7IHHzd4F6 M{jiblQ5KGh? MlO4TWM2OCB;IECuNFQh|ryP NH3KUWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUezNFI1Oyd-MUW3N|AzPDN:L3G+
Hep G2 NFu1WXdEgXSxdH;4bYNqfHliYYPzZZk> NYPPS|Q4PDhiaB?= MnzOTWM2OCB;IEiuNUDPxE1? MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTd|MEK0N{c,OTV5M{CyOFM9N2F-
A549 NXrh[IQ{S3m2b4TvfIlkcXS7IHHzd4F6 MXS0PEBp NXXPR5pOUUN3MDC9JFEvOjVizszN MlzGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV5OEe0OlAoRjF3N{i3OFYxRC:jPh?=
SKOV3 Mo[3R5l1d3SxeHnjbZR6KGG|c3H5 MVO0PEBp NVPHPII4UUN3MDC9JFEvOzVizszN M{nVb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3N{i3OFYxLz5zNUe4O|Q3ODxxYU6=
KB MmXqR5l1d3SxeHnjbZR6KGG|c3H5 MkP0N{Bl[Xm| M2DXb2lEPTBiPTCwMlAxOSEQvF2= M{fqcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4MEO4OVQ2Lz5zNkCzPFU1PTxxYU6=
1A9 NV;0bZY{S3m2b4TvfIlkcXS7IHHzd4F6 NXPYU4h5OyCmYYnz NGDYN5ZKSzVyIE2gNE4xODJizszN MonPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZyM{i1OFUoRjF4MEO4OVQ2RC:jPh?=
HCT8 MkjCR5l1d3SxeHnjbZR6KGG|c3H5 NHPWXlE{KGSjeYO= MYDJR|UxKD1iMD6wNVMh|ryP MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjB|OEW0OUc,OTZyM{i1OFU9N2F-
A431 NIm3cmVE\WyuIHP5Z4xmKGG{cnXzeEBie3OjeR?= NF3ncZhGSzVyIE2gNE4xODlizszN NV;FdZNFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[zO|cyQDdpPkG2N|c4OTh5PD;hQi=>
VA13 MnXvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkW1OFghcA>? NEPmdmZKSzVyIE2gNE4xODR|IN88US=> M1Tq[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEm5N|IzLz5zNkS5PVMzOjxxYU6=
WI38 NHK2XoVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGK5U4M1QCCq MWLJR|UxKD1iMD6wN|Qh|ryP MoPQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2OUmzNlIoRjF4NEm5N|IzRC:jPh?=
HepG2 NUT3eHRDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Moi4OFghcA>? NGjQOoFKSzVyIE2gOk46KM7:TR?= MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjR7OUOyNkc,OTZ2OUmzNlI9N2F-
Aro M3\ifGN6fG:2b4jpZ4l1gSCjc4PhfS=> MV3JR|UxKD1iMD6wNFAzKM7:TR?= MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjV|OUO3O{c,OTZ3M{mzO|c9N2F-
PT45 MYLDfZRwfG:6aXPpeJkh[XO|YYm= M3O3XGlEPTBiPTCwMlAxPSEQvF2= NHrVV|Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkWzPVM4Pyd-MU[1N|k{Pzd:L3G+
A549 NYTnSm1RS3m2b4TvfIlkcXS7IHHzd4F6 MVTJR|UxKD1iMD6wNFYh|ryP MlvVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ3M{mzO|coRjF4NUO5N|c4RC:jPh?=
MCF7 M{PTb2N6fG:2b4jpZ4l1gSCjc4PhfS=> M1z0TWlEPTBiPTCwMlAxPyEQvF2= MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjV|OUO3O{c,OTZ3M{mzO|c9N2F-
HeLa NGnSS21EgXSxdH;4bYNqfHliYYPzZZk> NXfqUVlDUUN3MDC9JFAvODB6IN88US=> MmGyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ3M{mzO|coRjF4NUO5N|c4RC:jPh?=
Ovcar3 Mk\TR5l1d3SxeHnjbZR6KGG|c3H5 NEPwdm9KSzVyIE2gNE4xOSEQvF2= MnK2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ3M{mzO|coRjF4NUO5N|c4RC:jPh?=
HT29 NYGxVWc4S3m2b4TvfIlkcXS7IHHzd4F6 MVnJR|UxKD1iMD6wOUDPxE1? MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjV|OUO3O{c,OTZ3M{mzO|c9N2F-
H295R NUG1VGJ6S3m2b4TvfIlkcXS7IHHzd4F6 MkLXTWM2OCB;IECuNFgh|ryP Mn7RQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ3M{mzO|coRjF4NUO5N|c4RC:jPh?=
BNL MlL6R5l1d3SxeHnjbZR6KGG|c3H5 NGX0boZKSzVyIE2gNE4zKM7:TR?= MoHpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ3M{mzO|coRjF4NUO5N|c4RC:jPh?=
4T1 MXvDfZRwfG:6aXPpeJkh[XO|YYm= Mnz3TWM2OCB;IECuNkDPxE1? Mn\4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ3M{mzO|coRjF4NUO5N|c4RC:jPh?=
HepG2 MnjOR5l1d3SxeHnjbZR6KGG|c3H5 M1vWXmlEPTBiPTCwMlMh|ryP MmLvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ3M{mzO|coRjF4NUO5N|c4RC:jPh?=
U937 GTB M4PXPWN6fG:2b4jpZ4l1gSCjc4PhfS=> MXK3NkBp NUC3bXJXUUN3MDC9JFAvODB3OTFOwG0> NELHUHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkW2Nlg1OCd-MU[1OlI5PDB:L3G+
RPMI 8226/s Mn\XR5l1d3SxeHnjbZR6KGG|c3H5 MnzKO|IhcA>? Mn3RTWM2OCB;IECuNFA4KM7:TR?= NHLBZWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkW2Nlg1OCd-MU[1OlI5PDB:L3G+
CEM/s NY\UZXA1S3m2b4TvfIlkcXS7IHHzd4F6 NF\yPY04OiCq NXjlbGZWUUN3MDC9JFAvODB5IN88US=> MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjV4Mki0NEc,OTZ3NkK4OFA9N2F-
VA13 MoH4R5l1d3SxeHnjbZR6KGG|c3H5 MVzJR|UxKD1iMD6wNFU6KM7:TR?= MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjd{NEi0Nkc,OTZ5MkS4OFI9N2F-
WI38 M1nEOWN6fG:2b4jpZ4l1gSCjc4PhfS=> MX\JR|UxKD1iMD6wOFY5KM7:TR?= M3v6OlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4N{K0PFQzLz5zNkeyOFg1OjxxYU6=
HepG2 MULDfZRwfG:6aXPpeJkh[XO|YYm= M3ywVGlEPTBiPTC5MlQ6KM7:TR?= NF7Fboc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkeyOFg1Oid-MU[3NlQ5PDJ:L3G+
HT29 NU\HTXNPS3m2b4TvfIlkcXS7IHHzd4F6 M3fl[GVEPTBiPTCwMlAxPiEQvF2= NGXxcHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNki3NFQzQCd-MU[4O|A1Ojh:L3G+
K562 NUDjPVhLS3m2b4TvfIlkcXS7IHHzd4F6 NFvZfGVGSzVyIE2gNE4xOTRizszN MofDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ6N{C0NlgoRjF4OEewOFI5RC:jPh?=
MCF7 NGDXSZNEgXSxdH;4bYNqfHliYYPzZZk> M{LwbmVEPTBiPTCwMlA{PiEQvF2= MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjh5MESyPEc,OTZ6N{C0Nlg9N2F-
VA-13 M4LxXWN6fG:2b4jpZ4l1gSCjc4PhfS=> NFG1cY9KSzVyIE2gNE4xODVizszN NX;DVYdxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[5N|M5PjhpPkG2PVM{QDZ6PD;hQi=>
WI38 NFe2[ZlEgXSxdH;4bYNqfHliYYPzZZk> MlrITWM2OCB;IECuNFQh|ryP M{[3[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4OUOzPFY5Lz5zNkmzN|g3QDxxYU6=
VA13 M4DhT2N6fG:2b4jpZ4l1gSCjc4PhfS=> NWH2NoJYUUN3MDC9JFAvODB3IN88US=> Mo\vQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyNkexOVUoRjF5ME[3NVU2RC:jPh?=
WI38 MlTuR5l1d3SxeHnjbZR6KGG|c3H5 MmSzTWM2OCB;IECuNFQh|ryP MlL2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyNkexOVUoRjF5ME[3NVU2RC:jPh?=
Hep G2 MXjDfZRwfG:6aXPpeJkh[XO|YYm= MnvxTWM2OCB;IEiuNUDPxE1? MnqwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyNkexOVUoRjF5ME[3NVU2RC:jPh?=
TW01 M{Djc2N6fG:2b4jpZ4l1gSCjc4PhfS=> NFv6fnFKSzVyIE2gNE4xODB|IN88US=> M1zQOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUGzNlg5Lz5zN{GxN|I5QDxxYU6=
MCF7 NFHWcGhEgXSxdH;4bYNqfHliYYPzZZk> MVHJR|UxKD1iMD6wNFA2KM7:TR?= MkT6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzMUOyPFgoRjF5MUGzNlg5RC:jPh?=
MKN45 MY\DfZRwfG:6aXPpeJkh[XO|YYm= NUnFRYs1UUN3MDC9JFAvODByNTFOwG0> M33DeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUGzNlg5Lz5zN{GxN|I5QDxxYU6=
MES-SA NH\yNHREgXSxdH;4bYNqfHliYYPzZZk> Ml64TWM2OCB;IECuNFAxPSEQvF2= M1vHc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUGzNlg5Lz5zN{GxN|I5QDxxYU6=
HCT116 MWnDfZRwfG:6aXPpeJkh[XO|YYm= NWO2W|V1UUN3MDC9JFAvODByNjFOwG0> NYPBUXM5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexNVMzQDhpPkG3NVE{Ojh6PD;hQi=>
RPTEC MlXGR5l1d3SxeHnjbZR6KGG|c3H5 M2\RZWlEPTBiPTCwMlAxODlizszN M2fidlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUGzNlg5Lz5zN{GxN|I5QDxxYU6=
Hep3B MofIR5l1d3SxeHnjbZR6KGG|c3H5 Mk\RTWM2OCB;IECuNFA2PCEQvF2= MkSxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzMUOyPFgoRjF5MUGzNlg5RC:jPh?=
NCI-H226 NXeydYM5S3m2b4TvfIlkcXS7IHHzd4F6 MUXJR|UxKD1iMD6wNFY5KM7:TR?= MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzFzM{K4PEc,OTdzMUOyPFg9N2F-
A498 NVrvemxtS3m2b4TvfIlkcXS7IHHzd4F6 NV35XW05UUN3MDC9JFAvODZzIN88US=> M3zRb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUGzNlg5Lz5zN{GxN|I5QDxxYU6=
MDA435/LCC6 M4rjcWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MmrtTWM2OCB;IECuNFAzQSEQvF2= NH\XR|Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G1OFUxPSd-MUexOVQ2ODV:L3G+
multidrug resistant MDA435/LCC6 NH65[VRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MYLJR|UxKD1iMD6wNFQ5KM7:TR?= MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF3NEWwOUc,OTdzNUS1NFU9N2F-
P388 MnrMRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MVjJR|UxKD1iMD6wNlIh|ryP NH[yNVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G1OFUxPSd-MUexOVQ2ODV:L3G+
adriamycin resistant P388 NHG4bm9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MmT4TWM2OCB;IECuNFMh|ryP NIDTd4o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G1OFUxPSd-MUexOVQ2ODV:L3G+
LT12 NV3WVmU5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MnPHOFghcA>? NEfMTnBKSzVyIE2gNE4xODZizszN NGezelM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G4NVE3PCd-MUexPFEyPjR:L3G+
SKOV3 M{\HTGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MmLIOFghcA>? MXLJR|UxKD1iMD6wNUDPxE1? NWTERVBFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPjRpPkG3NVgyOTZ2PD;hQi=>
NCI-H460 MXTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MXi0PEBp M1XU[WlEPTBiPTCwMlAyKM7:TR?= MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG2OEc,OTdzOEGxOlQ9N2F-
SF268 MlrwRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MmPSOFghcA>? NHfheJZKSzVyIE2gNE4xOSEQvF2= M3jQR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVY1Lz5zN{G4NVE3PDxxYU6=
RKO MUTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MlnJOFghcA>? M{\XfmlEPTBiPTCwMlAyKM7:TR?= NFLud4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G4NVE3PCd-MUexPFEyPjR:L3G+
KB/HeLa M4HEVmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MXG0PEBp M3zPfmlEPTBiPTCwMlAyKM7:TR?= NWjZT3BxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPjRpPkG3NVgyOTZ2PD;hQi=>
P388 MYTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M1nRN|Q5KGh? MkXpTWM2OCB;IECuNFQh|ryP M{DpbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVY1Lz5zN{G4NVE3PDxxYU6=
L1210 M1zK[2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NWHCO5I4PDhiaB?= NWfWdHFFUUN3MDC9JFAvODZizszN MlXqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOEGxOlQoRjF5MUixNVY1RC:jPh?=
LT12 MDR NF70PHdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NHnMSXk1QCCq MWHJR|UxKD1iMD60JO69VQ>? MlTRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOEGxOlQoRjF5MUixNVY1RC:jPh?=
A2780 NEDycItEgXSxdH;4bYNqfHliYYPzZZk> MWjJR|UxKD1iMD6wNFEh|ryP MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzJyNkGzPUc,OTd{ME[xN|k9N2F-
A2780-1A9 NH33UGFEgXSxdH;4bYNqfHliYYPzZZk> MnPNTWM2OCB;IECuNFAyOSEQvF2= MnPNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd{ME[xN|koRjF5MkC2NVM6RC:jPh?=
A549 MkHyR5l1d3SxeHnjbZR6KGG|c3H5 MYHJR|UxKD1iMD6wNFM3KM7:TR?= M4\OZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MkC2NVM6Lz5zN{KwOlE{QTxxYU6=
1A9PTX22 MlLKR5l1d3SxeHnjbZR6KGG|c3H5 M{H4ZmlEPTBiPTCwMlAyQSEQvF2= MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzJyNkGzPUc,OTd{ME[xN|k9N2F-
1A9PTX10 MX\DfZRwfG:6aXPpeJkh[XO|YYm= NGPoUpdKSzVyIE2gNE4xOyEQvF2= M{jYOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MkC2NVM6Lz5zN{KwOlE{QTxxYU6=
A2780AD Mk\KR5l1d3SxeHnjbZR6KGG|c3H5 Mk\vTWM2OCB;IECuPUDPxE1? M3v6V|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MkC2NVM6Lz5zN{KwOlE{QTxxYU6=
KB Ml71RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MlrlTWM2OCB;IECuNFAzPDVizszN MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzJ{OEi3N{c,OTd{Mki4O|M9N2F-
COLO205 NX;wfmlZS3m2b4TvfIlkcXS7IHHzd4F6 NFS2O3lKSzVyIE2gNE4xODN|IN88US=> NUHGVZAzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUeyNlg5PzNpPkG3NlI5QDd|PD;hQi=>
KB8.5 MW\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NYfqbVEzUUN3MDC9JFAvODJ4IN88US=> MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzJ{OEi3N{c,OTd{Mki4O|M9N2F-
KBV1 MlnjRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NUToWY9yUUN3MDC9JFIvODF|IN88US=> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzJ{OEi3N{c,OTd{Mki4O|M9N2F-
A2780 MX7DfZRwfG:6aXPpeJkh[XO|YYm= NIjBV2FKSzVyIE2gNE4xODB5IN88US=> Ml\oQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd{M{m1PVcoRjF5MkO5OVk4RC:jPh?=
2780AD M3vtOmN6fG:2b4jpZ4l1gSCjc4PhfS=> MUDJR|UxKD1iMD61N|Uh|ryP MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzJ|OUW5O{c,OTd{M{m1PVc9N2F-
1A9 NEHFVZZEgXSxdH;4bYNqfHliYYPzZZk> Mnr1SWQ2OCB;IECuNFAyKM7:TR?= MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzN3MEizOEc,OTd|NUC4N|Q9N2F-
MCF7 M2XVPGN6fG:2b4jpZ4l1gSCjc4PhfS=> NUOz[VN1TUR3MDC9JFAvODBzMTFOwG0> MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzN3MEizOEc,OTd|NUC4N|Q9N2F-
DU145 Moq0R5l1d3SxeHnjbZR6KGG|c3H5 MUHFSFUxKD1iMD6wNFE{KM7:TR?= NEj5V3I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{O1NFg{PCd-MUezOVA5OzR:L3G+
KB MVTDfZRwfG:6aXPpeJkh[XO|YYm= NXPwPYQyTUR3MDC9JFAvODBzODFOwG0> M3;NUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5M{WwPFM1Lz5zN{O1NFg{PDxxYU6=
A549 MXvDfZRwfG:6aXPpeJkh[XO|YYm= MX3FSFUxKD1iMD6wNFI{KM7:TR?= NEjBUY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{O1NFg{PCd-MUezOVA5OzR:L3G+
LNCAP M2Hr[GN6fG:2b4jpZ4l1gSCjc4PhfS=> NVq0ZY9kTUR3MDC9JFAvODB{NjFOwG0> MlKzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd|NUC4N|QoRjF5M{WwPFM1RC:jPh?=
PC3 Ml7RR5l1d3SxeHnjbZR6KGG|c3H5 NYPJV2V6TUR3MDC9JFAvODV3NTFOwG0> MnHUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd|NUC4N|QoRjF5M{WwPFM1RC:jPh?=
KBVIN M4j6fWN6fG:2b4jpZ4l1gSCjc4PhfS=> MW\FSFUxKD1iMD6zNVEh|ryP Mn7ZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd|NUC4N|QoRjF5M{WwPFM1RC:jPh?=
A2780 MXzDfZRwfG:6aXPpeJkh[XO|YYm= MnLYTWM2OCB;IECuNFAyPiEQvF2= NXrMWndsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUezPVU1PjVpPkG3N|k2PDZ3PD;hQi=>
A2780/AD NIn5SpREgXSxdH;4bYNqfHliYYPzZZk> NEnvSJVKSzVyIE2gNE46OiEQvF2= NWLEb4Z1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUezPVU1PjVpPkG3N|k2PDZ3PD;hQi=>
KB NUTybZMzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M{LkTWlEPTBiPTCwMlAxOjR3IN88US=> M3XqWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEG2OVI1Lz5zN{SxOlUzPDxxYU6=
COLO205 MVHDfZRwfG:6aXPpeJkh[XO|YYm= NYHLVIx{UUN3MDC9JFAvODB|MzFOwG0> NHPufWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{SxOlUzPCd-MUe0NVY2OjR:L3G+
KB8.5 NVvBe3p5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MXvJR|UxKD1iMD6wNlYh|ryP MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRzNkWyOEc,OTd2MU[1NlQ9N2F-
KBV1 MUDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M3HoXWlEPTBiPTCyMlAyOyEQvF2= NY\SS|ZORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0NVY2OjRpPkG3OFE3PTJ2PD;hQi=>
neural precursor MlPZRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MXrFR|UxKD1iMD6wNUDPxE1? MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRzN{[zNUc,OTd2MUe2N|E9N2F-
OVCAR-3 NIXFNWFEgXSxdH;4bYNqfHliYYPzZZk> M1nFb2lEPTBiPTCwMlAxODJizszN NF3QVpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{SxPVA3PSd-MUe0NVkxPjV:L3G+
MDA-MB-231 MnvGR5l1d3SxeHnjbZR6KGG|c3H5 NEPRc4VKSzVyIE2gNE4xODR3IN88US=> NXjsRndORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0NVkxPjVpPkG3OFE6ODZ3PD;hQi=>
MCF7 M{P2fmN6fG:2b4jpZ4l1gSCjc4PhfS=> NW\mdYNPUUN3MDC9JFAvODB2OTFOwG0> MmXjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2MUmwOlUoRjF5NEG5NFY2RC:jPh?=
NCI-H1299 NVK1ZW9WS3m2b4TvfIlkcXS7IHHzd4F6 MYW5OkBp NFLZZYVKSzVyIE2gNE4xOTVizszN NWT5eZdvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0NVkxPjVpPkG3OFE6ODZ3PD;hQi=>
A2780 NH20TYtEgXSxdH;4bYNqfHliYYPzZZk> NX;te4FLUUN3MDC9JFAvODJ3IN88US=> NHPvUmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{SxPVA3PSd-MUe0NVkxPjV:L3G+
PC3 MlzQR5l1d3SxeHnjbZR6KGG|c3H5 NX7GRXJjUUN3MDC9JFAvODd5IN88US=> NGP6V5Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{SxPVA3PSd-MUe0NVkxPjV:L3G+
LoVo M1HFWmN6fG:2b4jpZ4l1gSCjc4PhfS=> MUDJR|UxKD1iMD6wPUDPxE1? NWLwVmhNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0NVkxPjVpPkG3OFE6ODZ3PD;hQi=>
L2987 MVjDfZRwfG:6aXPpeJkh[XO|YYm= M3uwcWlEPTBiPTCwMlIh|ryP NX;QXYZmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0NVkxPjVpPkG3OFE6ODZ3PD;hQi=>
cells MlzQR5l1d3SxeHnjbZR6KGG|c3H5 NUPsNodLUUN3MDC9JFAvODB3OTFOwG0> NWLlcnhiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0OFI2PzdpPkG3OFQzPTd5PD;hQi=>
cells NWLqR3c4S3m2b4TvfIlkcXS7IHHzd4F6 NW[4cHRmUUN3MDC9JFAvODFizszN NUHT[VVORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0PFUzODdpPkG3OFg2OjB5PD;hQi=>
A2780 NWG5OVZbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3zJdmlEPTBiPTCwMlAxOjhizszN NXTobmFlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0PVA5PzhpPkG3OFkxQDd6PD;hQi=>
VA13 NFrIVHVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4[y[GlEPTBiPTCwMlAxPSEQvF2= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR7MEi3PEc,OTd2OUC4O|g9N2F-
WI38 MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXPJR|UxKD1iMD6wOEDPxE1? NHv6dXg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S5NFg4QCd-MUe0PVA5Pzh:L3G+
2780AD MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{nRO2lEPTBiPTCwMlE5OyEQvF2= NXP2WoltRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0PVA5PzhpPkG3OFkxQDd6PD;hQi=>
HepG2 MnuzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4rDXGlEPTBiPTC4MlEh|ryP MlrpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2OUC4O|goRjF5NEmwPFc5RC:jPh?=
HT29 M{TzWGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUL5fJFDPDhiaB?= M13QfmdKPTBiPTCwMlAyPSEQvF2= NH;KU|c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S5PFk3OCd-MUe0PVg6PjB:L3G+
M21 M2LHRmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFvkXGE1QCCq MXnHTVUxKD1iMD6wN|ch|ryP MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR7OEm2NEc,OTd2OUi5OlA9N2F-
MCF7 NXLFT2hwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mnf6OFghcA>? Moi1S2k2OCB;IECuNFU1KM7:TR?= NVm3UJA4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0PVg6PjBpPkG3OFk5QTZyPD;hQi=>
1A9 NX3XTZNpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXHEZmlxPzJiaB?= NHi2XoJIUTVyIE2gNE4xODB5MTFOwG0> M3vNSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUSyOVczLz5zN{W0NlU4OjxxYU6=
1A9/Ptx22 NWHHWlhLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHe1RYk4OiCq Mn6xS2k2OCB;IECuNFUyKM7:TR?= Mlq5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NEK1O|IoRjF5NUSyOVczRC:jPh?=
1A9/Ptx10 MYHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoTjO|IhcA>? MYDHTVUxKD1iMD6wOlQh|ryP NV7Uc2o6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OFI2PzJpPkG3OVQzPTd{PD;hQi=>
cells expressing MRP1 Mnj3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXXO[ZQxUUN3MDC9JFAvODB{NTFOwG0> MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV4N{GyNUc,OTd3NkexNlE9N2F-
cells expressing Pgp/MRP1 MoH3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1rFe2lEPTBiPTCyMlch|ryP MmHJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NkexNlEoRjF5NU[3NVIyRC:jPh?=
VA13 NXnvW5NmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVLJR|UxKD1iNTFOwG0> MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV7NUGzOEc,OTd3OUWxN|Q9N2F-
MCF7 M3LTSmZ2dmO2aX;uJIF{e2G7 NWPtSJE3UUN3MDC9JFAvODBzODFOwG0> M1m0dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NkCxO|M6Lz5zN{[wNVc{QTxxYU6=
adriamycin-resistant MCF7 NWfYUFFKTnWwY4Tpc44h[XO|YYm= NH7VTlhKSzVyIE2gPE4zKM7:TR?= NYX5eodURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2NFE4OzlpPkG3OlAyPzN7PD;hQi=>
RPMI8226 MVzDfZRwfG:6aXPpeJkh[XO|YYm= NVn1UmJWT0l3MDC9JFAvODB{IN88US=> NVqxVI41RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2PVY{OzJpPkG3Olk3OzN{PD;hQi=>
HT29 MYfDfZRwfG:6aXPpeJkh[XO|YYm= MkHtS2k2OCB;IECuNFAzKM7:TR?= MnHMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4OU[zN|IoRjF5Nkm2N|MzRC:jPh?=
COLO205 M{j4NmN6fG:2b4jpZ4l1gSCjc4PhfS=> NIL5TY5IUTVyIE2gNE4xODNizszN M2PYVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Nkm2N|MzLz5zN{[5OlM{OjxxYU6=
HCC2998 M3;kfGN6fG:2b4jpZ4l1gSCjc4PhfS=> M13wNWdKPTBiPTCwMlAxOyEQvF2= MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ7NkOzNkc,OTd4OU[zN|I9N2F-
HS578T MWXDfZRwfG:6aXPpeJkh[XO|YYm= NYTNPXlrT0l3MDC9JFAvODB|IN88US=> MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ7NkOzNkc,OTd4OU[zN|I9N2F-
PC3 M37UcmN6fG:2b4jpZ4l1gSCjc4PhfS=> MoP2S2k2OCB;IECuNFA1KM7:TR?= NH3mcW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[5OlM{Oid-MUe2PVY{OzJ:L3G+
SNB75 MWDDfZRwfG:6aXPpeJkh[XO|YYm= NXGwboZMT0l3MDC9JFAvODB2IN88US=> Mn3OQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4OU[zN|IoRjF5Nkm2N|MzRC:jPh?=
A549 NWDifIdTS3m2b4TvfIlkcXS7IHHzd4F6 MXPHTVUxKD1iMD6wNFQh|ryP MoDmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4OU[zN|IoRjF5Nkm2N|MzRC:jPh?=
KM12 NUSwXFFXS3m2b4TvfIlkcXS7IHHzd4F6 MoHLS2k2OCB;IECuNFA1KM7:TR?= MkiwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4OU[zN|IoRjF5Nkm2N|MzRC:jPh?=
DU145 NHnTeZhEgXSxdH;4bYNqfHliYYPzZZk> M2TobmdKPTBiPTCwMlAxPSEQvF2= MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ7NkOzNkc,OTd4OU[zN|I9N2F-
SK-OV3 Mn7SR5l1d3SxeHnjbZR6KGG|c3H5 NYHJcIEyT0l3MDC9JFAvODB6IN88US=> NWTFbZo5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2PVY{OzJpPkG3Olk3OzN{PD;hQi=>
NCI-H322M MXzDfZRwfG:6aXPpeJkh[XO|YYm= NEDhRnBIUTVyIE2gNE4xOTNizszN MmOzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4OU[zN|IoRjF5Nkm2N|MzRC:jPh?=
UACC257 NEDITndEgXSxdH;4bYNqfHliYYPzZZk> NWLOclZKT0l3MDC9JFAvODRizszN NF32bm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[5OlM{Oid-MUe2PVY{OzJ:L3G+
HCT15 M2X2fmN6fG:2b4jpZ4l1gSCjc4PhfS=> MoDOS2k2OCB;IECuNVU5KM7:TR?= M3jDRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Nkm2N|MzLz5zN{[5OlM{OjxxYU6=
ACHN MVvDfZRwfG:6aXPpeJkh[XO|YYm= MorWS2k2OCB;IECuN|k5KM7:TR?= MmPrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4OU[zN|IoRjF5Nkm2N|MzRC:jPh?=
HeLa Mm\kR5l1d3SxeHnjbZR6KGG|c3H5 NITQZ5RKSzVyIE2gNE4xODV4IN88US=> NXz4[|N3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe3OlQyPDhpPkG3O|Y1OTR6PD;hQi=>
MCF7 MUTDfZRwfG:6aXPpeJkh[XO|YYm= MXnJR|UxKD1iMD6wNVI1KM7:TR?= Mm[wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd5NkSxOFgoRjF5N{[0NVQ5RC:jPh?=
A549 MXXDfZRwfG:6aXPpeJkh[XO|YYm= NWrQ[|VYUUN3MDC9JFAvODF{NjFOwG0> M1TvZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5N{[0NVQ5Lz5zN{e2OFE1QDxxYU6=
HGC27 MnL1R5l1d3SxeHnjbZR6KGG|c3H5 NY\KXJo3UUN3MDC9JFAvPzd5ODFOwG0> MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzd4NEG0PEc,OTd5NkSxOFg9N2F-
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