Paclitaxel (NSC 125973)

For research use only. Not for use in humans.

製品コードS1150 別名:PTX, Taxol, Onxal, Abraxane

Paclitaxel (NSC 125973)化学構造

CAS No. 33069-62-4

Paclitaxel (NSC 125973, PTX, Taxol, Onxal, Abraxane) is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.

サイズ 価格(税別)  
10mM (1mL in DMSO) JPY 17100
JPY 13600
JPY 46800
JPY 69700
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バルク問合せ

文献中Selleckの製品使用例(300)

製品安全説明書

Antineoplastic and Immunosuppressive Antibiotics阻害剤の選択性比較

生物活性

製品説明 Paclitaxel (NSC 125973, PTX, Taxol, Onxal, Abraxane) is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.
ターゲット
Microtubule (human endothelial cells) [1]
0.1 pM
体外試験

Paclitaxel inhibits non-endothelial type human cells at 104 - to 105 -fold higher concentrations, with IC50 of 1 nM-10 nM. The selectivity of Paclitaxel inhibition of cell proliferation is also species specific, as mouse ECs are not sensitive to Paclitaxel at ultra low concentrations. Inhibition of human ECs by Paclitaxel at ultra low concentrations does not affect the cellular microtubule structure, and the treated cells do not show G2/M cell cycle arrest and apoptosis, suggesting a novel but as yet unidentified mechanism of action. In an in vitro angiogenesis assay, Paclitaxel at ultra low concentrations blocks human ECs from forming sprouts and tubes in the three-dimensional fibrin matrix. [1] In the presence of SMF, the efficient concentration of Paclitaxel on K562 cells is decreased from 50 to 10 ng/mL. The cell cycle arrest effect of Paclitaxel with or without SMF on K562 cells is correlated with DNA damage. [2] Paclitaxel alone causes a time-dependent inhibition of CDK1 in four cell lines including A549 cells, H358, H1395 cells and H1666 cells. [3]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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NH-12 MlPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUT1NVdmUUN3MDC9JFI1NjF4NUSg{txO Ml\HQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI5PjR5Lze+V2FPT0WUPD;hQi=>
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NB10 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PXNGlEPTBiPTCzNU42ODlizszN MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0Nlg3PDdxJ{7TRW5ITVJ:L3G+
COLO205 MWfDfZRwfG:6aXPpeJkh[XO|YYm= M3W4NGdKPTBiPTCwMlAxOTd4IN88US=> MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84QTB6OUWwK|44QTB6OUWwQE9iRg>?
SF539 M3zIe2N6fG:2b4jpZ4l1gSCjc4PhfS=> MoTuS2k2OCB;IECuNFA{PjZizszN MnzyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwPzlyOEm1NEc,PzlyOEm1NFww[T5?
SNB75 NVuzcIpiS3m2b4TvfIlkcXS7IHHzd4F6 NGKwdJZIUTVyIE2gNE4xODhyODFOwG0> NUPS[4ZwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxN{mwPFk2OCd-N{mwPFk2ODxxYU6=
DMS114 MWPDfZRwfG:6aXPpeJkh[XO|YYm= NXLVO|lIT0l3MDC9JFAvODF{MzFOwG0> Ml;aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwPzlyOEm1NEc,PzlyOEm1NFww[T5?
OVCAR-3 M3LLWWN6fG:2b4jpZ4l1gSCjc4PhfS=> MkOxS2k2OCB;IECuNFE6PyEQvF2= MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84QTB6OUWwK|44QTB6OUWwQE9iRg>?
NCI-H460 MXnDfZRwfG:6aXPpeJkh[XO|YYm= M{XGSmdKPTBiPTCwMlAzOTlizszN NFTqZlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi95OUC4PVUxLz55OUC4PVUxRC:jPh?=
HOP62 MVjDfZRwfG:6aXPpeJkh[XO|YYm= NU\rUJhmT0l3MDC9JFAvODZ5MTFOwG0> M{i1NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzd7MEi5OVAoRjd7MEi5OVA9N2F-
mammary carcinoma MXXDfZRwfG:6aXPpeJkh[XO|YYm= MWjJR|UxKD1iMD6yPVkh|ryP NUjHUHNsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOEG4NlY6QCd-OEG4NlY6QDxxYU6=
NCI60 NUXQXGJbS3m2b4TvfIlkcXS7IHHzd4F6 NGDPRW1IUTVyIE2gNE4xODB4NTFOwG0> MlfyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTR4MU[1N{c,QTR4MU[1N|ww[T5?
MCF-7 MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUnHTVUxKD1iMD6wNFEyKM7:TR?= M{i2ZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl6N{O1PVcoRjl6N{O1PVc9N2F-
murine leukemic P388 M1q2emdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVziN5VMT0l3MDC9JFAvODF4IN88US=> MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86QDd|NUm3K|46QDd|NUm3QE9iRg>?
KB M4XoNmN6fG:2b4jpZ4l1gSCjc4PhfS=> MnPETWM2OCB;IECuNFA3KM7:TR?= MlSzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB7N{iyNFAoRjFyOUe4NlAxRC:jPh?=
MCF7 MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M4PLdFczKGh? NVLVe3ZnUUN3MDC9JFAvODB{IN88US=> M{KyOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzM{K1NlI3Lz5zMUOyOVIzPjxxYU6=
MCF-7 M2LrWGN6fG:2b4jpZ4l1gSCjc4PhfS=> NV3KVI9rTUR3MDC9JFAvODB2IN88US=> NVzGdYZ4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUGzN|Q2PjdpPkGxN|M1PTZ5PD;hQi=>
uterine sarcoma (MES-SA) MmTRR5l1d3SxeHnjbZR6KGG|c3H5 NUXMO5dbUUN3MDC9JFAvODByMESg{txO MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTd{OEG5NUc,OTF5MkixPVE9N2F-
nonsmall cell lung carcinoma (NCI-H460) NV;qNohbS3m2b4TvfIlkcXS7IHHzd4F6 NUW5N3A1UUN3MDC9JFAvODByMUSg{txO MlzhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF5MkixPVEoRjFzN{K4NVkyRC:jPh?=
colon adenocarcinoma (HT-29) NFX1VFBEgXSxdH;4bYNqfHliYYPzZZk> M1vT[mlEPTBiPTCwMlAxODF4IN88US=> Mn;sQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF5MkixPVEoRjFzN{K4NVkyRC:jPh?=
prostate carcinoma (DU-145) NG[yfVZEgXSxdH;4bYNqfHliYYPzZZk> NUDhdZc1UUN3MDC9JFAvODB2OEmg{txO NVO3XWd4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG3NlgyQTFpPkGxO|I5OTlzPD;hQi=>
SW626 M1;tU2N6fG:2b4jpZ4l1gSCjc4PhfS=> NEniU5M4OiCq NIjyVmlKSzVyIE2gNE4xODByMTFOwG0> MkC2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJyOEi0NlUoRjF{MEi4OFI2RC:jPh?=
Lu1 NUnCfZBXS3m2b4TvfIlkcXS7IHHzd4F6 NFS2fIk4OiCq NWr1bnRtUUN3MDC9JFAvODFizszN MnrkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJyOEi0NlUoRjF{MEi4OFI2RC:jPh?=
MCF7 MnPqR5l1d3SxeHnjbZR6KGG|c3H5 NHLjT2E4OiCq M1LUe2lEPTBiPTCwMlAzKM7:TR?= MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjB6OESyOUc,OTJyOEi0NlU9N2F-
P388 Ml\WR5l1d3SxeHnjbZR6KGG|c3H5 NF64VHU4OiCq NWSyVmNoUUN3MDC9JFAvODJizszN M3vWUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{MEi4OFI2Lz5zMkC4PFQzPTxxYU6=
LNCAP M2HvdGN6fG:2b4jpZ4l1gSCjc4PhfS=> MYG3NkBp Mlu4TWM2OCB;IECuNFIh|ryP MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjB6OESyOUc,OTJyOEi0NlU9N2F-
KB MYfDfZRwfG:6aXPpeJkh[XO|YYm= M4iyZ|czKGh? MoLYTWM2OCB;IECuNFIh|ryP NH7rO4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkC4PFQzPSd-MUKwPFg1OjV:L3G+
Col2 MWLDfZRwfG:6aXPpeJkh[XO|YYm= Ml;pO|IhcA>? NHzI[5JKSzVyIE2gNE4xOiEQvF2= NWf5TIRqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUKwPFg1OjVpPkGyNFg5PDJ3PD;hQi=>
BC1 NWL3SXpES3m2b4TvfIlkcXS7IHHzd4F6 MlrwO|IhcA>? MV3JR|UxKD1iMD6wNkDPxE1? Mn;KQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJyOEi0NlUoRjF{MEi4OFI2RC:jPh?=
SK-MEL-2 NUjVNoxbS3m2b4TvfIlkcXS7IHHzd4F6 Mm[2O|IhcA>? NFXCNlNKSzVyIE2gNE4xPyEQvF2= M4Dz[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{MEi4OFI2Lz5zMkC4PFQzPTxxYU6=
L2987 MULDfZRwfG:6aXPpeJkh[XO|YYm= NHz3WFNKSzVyIE2gNE4zKM7:TR?= MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjR2M{e4N{c,OTJ2NEO3PFM9N2F-
colon adenocarcinoma RKO NH;6cVJEgXSxdH;4bYNqfHliYYPzZZk> M1zTRmlEPTBiPTCwMlAyKM7:TR?= MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjh3Mke2PEc,OTJ6NUK3Olg9N2F-
NCI-H460 MkTGR5l1d3SxeHnjbZR6KGG|c3H5 NF6zWWI1QCCq MlXvTWM2OCB;IECuNFA6PSEQvF2= NX7SdppNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUS2PVU4QThpPkG0Olk2Pzl6PD;hQi=>
MCF7 NGDGRlBEgXSxdH;4bYNqfHliYYPzZZk> M1\uclQ5KGh? MVjJR|UxKD1iMD6wNVEzKM7:TR?= M{XIc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF2Nkm1O|k5Lz5zNE[5OVc6QDxxYU6=
SF268 MVXDfZRwfG:6aXPpeJkh[XO|YYm= M1nkN|Q5KGh? MUXJR|UxKD1iMD6wNlE4KM7:TR?= M4\rSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF2Nkm1O|k5Lz5zNE[5OVc6QDxxYU6=
MDA-MB-231 NWrJeHBDS3m2b4TvfIlkcXS7IHHzd4F6 NILEbW01QCCq MlraTWM2OCB;IECuNFA1PSEQvF2= NXrtUIRWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUS5PFcxPTFpPkG0PVg4ODVzPD;hQi=>
MCF7 M4TRSGN6fG:2b4jpZ4l1gSCjc4PhfS=> MVG0PEBp MUXJR|UxKD1iMD6wNFQ6KM7:TR?= MmPuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTR7OEewOVEoRjF2OUi3NFUyRC:jPh?=
A2780 MXXDfZRwfG:6aXPpeJkh[XO|YYm= NIjZRoQ1QCCq M{LzfmlEPTBiPTCwMlAzPSEQvF2= MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDl6N{C1NUc,OTR7OEewOVE9N2F-
PC3 Ml3SR5l1d3SxeHnjbZR6KGG|c3H5 NH;zfZg1QCCq MnfNTWM2OCB;IECuNFc4KM7:TR?= NETPWWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNEm4O|A2OSd-MUS5PFcxPTF:L3G+
MCF7 MVnDfZRwfG:6aXPpeJkh[XO|YYm= M2DCOVczKGh? NYDudpRzUUN3MDC9JFAvODBzNDFOwG0> M4XoTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF2OUi3NFU3Lz5zNEm4O|A2PjxxYU6=
multidrug-resistant MCF7 NF:3THNEgXSxdH;4bYNqfHliYYPzZZk> NFvZSmM4OiCq NWLpSoREUUN3MDC9JFAvOzV2IN88US=> MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDl6N{C1Okc,OTR7OEewOVY9N2F-
PC3 MYHDfZRwfG:6aXPpeJkh[XO|YYm= NUi2W29IPDhiaB?= M3rxV2lEPTBiPTCwMlAyPiEQvF2= M1nxO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MESzOFAzLz5zNUC0N|QxOjxxYU6=
Hep3B M3T0dGN6fG:2b4jpZ4l1gSCjc4PhfS=> NF3rOmc1QCCq MnrCTWM2OCB;IECuNFMyKM7:TR?= NYf6NlhXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWwOFM1ODJpPkG1NFQ{PDB{PD;hQi=>
NCI-H460 NY\nUVdwS3m2b4TvfIlkcXS7IHHzd4F6 NH7aNYE1QCCq MVnJR|UxKD1iMD6wNFk2KM7:TR?= NUDSenNkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWwOFM1ODRpPkG1NFQ{PDB2PD;hQi=>
MCF7 MUXDfZRwfG:6aXPpeJkh[XO|YYm= NF\QO2M1QCCq NULtUHpmUUN3MDC9JFAvODFzMjFOwG0> M4rrXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MESzOFA1Lz5zNUC0N|QxPDxxYU6=
SF268 NEXuVpdEgXSxdH;4bYNqfHliYYPzZZk> MV20PEBp NFfuUJdKSzVyIE2gNE4xOjF5IN88US=> NWWx[2NHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWwOFM1ODRpPkG1NFQ{PDB2PD;hQi=>
KB NFm1TYZEgXSxdH;4bYNqfHliYYPzZZk> MVPFSFUxKD1iMD6wNFA1KM7:TR?= M{nPcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MESzOFA4Lz5zNUC0N|QxPzxxYU6=
Lu1 NWrwV4NjS3m2b4TvfIlkcXS7IHHzd4F6 NH72V|lGTDVyIE2gNE4xODJizszN MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTB2M{SwO{c,OTVyNEO0NFc9N2F-
LNCAP M3jQcWN6fG:2b4jpZ4l1gSCjc4PhfS=> NIDh[WhGTDVyIE2gNE4xODVizszN NV;ZUYtxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWwOFM1ODdpPkG1NFQ{PDB5PD;hQi=>
RPE1 MYnDfZRwfG:6aXPpeJkh[XO|YYm= MVTFSFUxKD1iMD6wNlMh|ryP NFTveXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUC0N|QxPyd-MUWwOFM1ODd:L3G+
Col2 MVrDfZRwfG:6aXPpeJkh[XO|YYm= MkSySWQ2OCB;IECuNFQ3KM7:TR?= NVr2OG1oRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWwOFM1ODdpPkG1NFQ{PDB5PD;hQi=>
T47D MoL5RZBweHSxc3nzJIF{e2G7 MXWyOEBp MYPFR|UxKD1iMD6wN{DPxE1? NHHTR3I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUW2OlMxOCd-MUW1OlY{ODB:L3G+
DLD1 MYTBdI9xfG:|aYOgZZN{[Xl? M1XCTFI1KGh? NF;ySIVGSzVyIE2gNE4xPzVizszN NHm5TnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUW2OlMxOCd-MUW1OlY{ODB:L3G+
H1299 M{TLcmFxd3C2b4Ppd{Bie3OjeR?= NV22VY1sOjRiaB?= M3y1NWVEPTBiPTCwMlE3OyEQvF2= NVHQfmNjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW1OlY{ODBpPkG1OVY3OzByPD;hQi=>
VA13 NVfifnMyS3m2b4TvfIlkcXS7IHHzd4F6 NX3nTFlIPDhiaB?= MYnJR|UxKD1iMD6wNFUh|ryP MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTd|MEK0N{c,OTV5M{CyOFM9N2F-
WI 38 NW\Te5F5S3m2b4TvfIlkcXS7IHHzd4F6 MmDxOFghcA>? MYHJR|UxKD1iMD6wOEDPxE1? MoGwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV5M{CyOFMoRjF3N{OwNlQ{RC:jPh?=
Hep G2 NGDLVppEgXSxdH;4bYNqfHliYYPzZZk> M2q1dVQ5KGh? MVnJR|UxKD1iOD6xJO69VQ>? NYTpVIJtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW3N|AzPDNpPkG1O|MxOjR|PD;hQi=>
A549 NXTEd4J6S3m2b4TvfIlkcXS7IHHzd4F6 MXO0PEBp M4PofmlEPTBiPTCxMlI2KM7:TR?= NWfiTWJHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW3PFc1PjBpPkG1O|g4PDZyPD;hQi=>
SKOV3 M{HzemN6fG:2b4jpZ4l1gSCjc4PhfS=> MXO0PEBp NFTVRmJKSzVyIE2gNU4{PSEQvF2= NYO4UVRPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW3PFc1PjBpPkG1O|g4PDZyPD;hQi=>
KB NWXCd4FWS3m2b4TvfIlkcXS7IHHzd4F6 NX;PS|hrOyCmYYnz MmLXTWM2OCB;IECuNFAyKM7:TR?= M4jzfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4MEO4OVQ2Lz5zNkCzPFU1PTxxYU6=
1A9 MWPDfZRwfG:6aXPpeJkh[XO|YYm= NXXtVHVbOyCmYYnz NGDHS2xKSzVyIE2gNE4xODJizszN MmCyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZyM{i1OFUoRjF4MEO4OVQ2RC:jPh?=
HCT8 NVTofFdLS3m2b4TvfIlkcXS7IHHzd4F6 NWLPO4ppOyCmYYnz M4nkSmlEPTBiPTCwMlAyOyEQvF2= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjB|OEW0OUc,OTZyM{i1OFU9N2F-
A431 MVTD[YxtKGO7Y3zlJIFzemW|dDDhd5NigQ>? NHKxfG9GSzVyIE2gNE4xODlizszN NEXke|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkO3O|E5Pyd-MU[zO|cyQDd:L3G+
VA13 Mm\ZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{\xSlQ5KGh? MYLJR|UxKD1iMD6wNFQ{KM7:TR?= M2L3flxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEm5N|IzLz5zNkS5PVMzOjxxYU6=
WI38 NVXmcY1MT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mm\5OFghcA>? NU\GPYpsUUN3MDC9JFAvODN2IN88US=> Mlm0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2OUmzNlIoRjF4NEm5N|IzRC:jPh?=
HepG2 MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXzPVYFRPDhiaB?= NHvGSlJKSzVyIE2gOk46KM7:TR?= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjR7OUOyNkc,OTZ2OUmzNlI9N2F-
Aro NIrMZoJEgXSxdH;4bYNqfHliYYPzZZk> MnvaTWM2OCB;IECuNFAxOiEQvF2= MlTyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ3M{mzO|coRjF4NUO5N|c4RC:jPh?=
PT45 MkTKR5l1d3SxeHnjbZR6KGG|c3H5 NGTmbYdKSzVyIE2gNE4xODVizszN MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjV|OUO3O{c,OTZ3M{mzO|c9N2F-
A549 NV7UbGQ5S3m2b4TvfIlkcXS7IHHzd4F6 MYLJR|UxKD1iMD6wNFYh|ryP NXrOem9wRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[1N|k{PzdpPkG2OVM6Ozd5PD;hQi=>
MCF7 NHn3fVdEgXSxdH;4bYNqfHliYYPzZZk> MkfBTWM2OCB;IECuNFA4KM7:TR?= NIq5dI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkWzPVM4Pyd-MU[1N|k{Pzd:L3G+
HeLa MljER5l1d3SxeHnjbZR6KGG|c3H5 NGfHXWZKSzVyIE2gNE4xODhizszN MlnIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ3M{mzO|coRjF4NUO5N|c4RC:jPh?=
Ovcar3 MkLER5l1d3SxeHnjbZR6KGG|c3H5 MUjJR|UxKD1iMD6wNUDPxE1? MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjV|OUO3O{c,OTZ3M{mzO|c9N2F-
HT29 M131U2N6fG:2b4jpZ4l1gSCjc4PhfS=> M{PVXWlEPTBiPTCwMlA2KM7:TR?= M2TCU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NUO5N|c4Lz5zNkWzPVM4PzxxYU6=
H295R Ml\qR5l1d3SxeHnjbZR6KGG|c3H5 MojaTWM2OCB;IECuNFgh|ryP NYTFRphQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[1N|k{PzdpPkG2OVM6Ozd5PD;hQi=>
BNL MX;DfZRwfG:6aXPpeJkh[XO|YYm= MmLGTWM2OCB;IECuNkDPxE1? NXS4ZmtPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[1N|k{PzdpPkG2OVM6Ozd5PD;hQi=>
4T1 M{S5SGN6fG:2b4jpZ4l1gSCjc4PhfS=> MUTJR|UxKD1iMD6yJO69VQ>? M3:0SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NUO5N|c4Lz5zNkWzPVM4PzxxYU6=
HepG2 M{TYfWN6fG:2b4jpZ4l1gSCjc4PhfS=> M4S0VWlEPTBiPTCwMlMh|ryP M3z2TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NUO5N|c4Lz5zNkWzPVM4PzxxYU6=
U937 GTB MofYR5l1d3SxeHnjbZR6KGG|c3H5 MVq3NkBp Mnz1TWM2OCB;IECuNFA2QSEQvF2= MkTBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ3NkK4OFAoRjF4NU[yPFQxRC:jPh?=
RPMI 8226/s NV\MNXlOS3m2b4TvfIlkcXS7IHHzd4F6 MUS3NkBp NYDHV4JFUUN3MDC9JFAvODB5IN88US=> M2nqclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NU[yPFQxLz5zNkW2Nlg1ODxxYU6=
CEM/s NIewS5BEgXSxdH;4bYNqfHliYYPzZZk> M2fSWlczKGh? M2jo[2lEPTBiPTCwMlAxPyEQvF2= NXO1Z3RJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[1OlI5PDBpPkG2OVYzQDRyPD;hQi=>
VA13 MlS4R5l1d3SxeHnjbZR6KGG|c3H5 M3r2PGlEPTBiPTCwMlAxPTlizszN NEHpV4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkeyOFg1Oid-MU[3NlQ5PDJ:L3G+
WI38 MoXJR5l1d3SxeHnjbZR6KGG|c3H5 M3TH[GlEPTBiPTCwMlA1PjhizszN NEPSe3E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkeyOFg1Oid-MU[3NlQ5PDJ:L3G+
HepG2 NWjHO497S3m2b4TvfIlkcXS7IHHzd4F6 NIPzWGRKSzVyIE2gPU41QSEQvF2= MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjd{NEi0Nkc,OTZ5MkS4OFI9N2F-
HT29 MWfDfZRwfG:6aXPpeJkh[XO|YYm= MWXFR|UxKD1iMD6wNFYh|ryP NFu1VWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNki3NFQzQCd-MU[4O|A1Ojh:L3G+
K562 NWrZSIF1S3m2b4TvfIlkcXS7IHHzd4F6 MYXFR|UxKD1iMD6wNVQh|ryP NXftbmdFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[4O|A1OjhpPkG2PFcxPDJ6PD;hQi=>
MCF7 M3vaeGN6fG:2b4jpZ4l1gSCjc4PhfS=> MY\FR|UxKD1iMD6wN|Yh|ryP MkjvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ6N{C0NlgoRjF4OEewOFI5RC:jPh?=
VA-13 MYrDfZRwfG:6aXPpeJkh[XO|YYm= M{XSTWlEPTBiPTCwMlAxPSEQvF2= MlLSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ7M{O4OlgoRjF4OUOzPFY5RC:jPh?=
WI38 NH3DSnVEgXSxdH;4bYNqfHliYYPzZZk> M1zGemlEPTBiPTCwMlA1KM7:TR?= NHzCfG49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkmzN|g3QCd-MU[5N|M5Pjh:L3G+
VA13 MmryR5l1d3SxeHnjbZR6KGG|c3H5 NFu1[XNKSzVyIE2gNE4xODVizszN MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzB4N{G1OUc,OTdyNkexOVU9N2F-
WI38 MmrnR5l1d3SxeHnjbZR6KGG|c3H5 MYnJR|UxKD1iMD6wOEDPxE1? NVf0e4V7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUewOlcyPTVpPkG3NFY4OTV3PD;hQi=>
Hep G2 NF\hdZpEgXSxdH;4bYNqfHliYYPzZZk> Ml7ITWM2OCB;IEiuNUDPxE1? MlrNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyNkexOVUoRjF5ME[3NVU2RC:jPh?=
TW01 MX7DfZRwfG:6aXPpeJkh[XO|YYm= M1;qNWlEPTBiPTCwMlAxODNizszN NUDhZVV4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexNVMzQDhpPkG3NVE{Ojh6PD;hQi=>
MCF7 M4C1fGN6fG:2b4jpZ4l1gSCjc4PhfS=> NXK3c3N7UUN3MDC9JFAvODByNTFOwG0> M2fzdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUGzNlg5Lz5zN{GxN|I5QDxxYU6=
MKN45 M2LzS2N6fG:2b4jpZ4l1gSCjc4PhfS=> NHWwTJlKSzVyIE2gNE4xODB3IN88US=> NXjRW4F7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexNVMzQDhpPkG3NVE{Ojh6PD;hQi=>
MES-SA MoK2R5l1d3SxeHnjbZR6KGG|c3H5 MoHTTWM2OCB;IECuNFAxPSEQvF2= MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzFzM{K4PEc,OTdzMUOyPFg9N2F-
HCT116 NUT4RmZSS3m2b4TvfIlkcXS7IHHzd4F6 NVPXcZc3UUN3MDC9JFAvODByNjFOwG0> MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzFzM{K4PEc,OTdzMUOyPFg9N2F-
RPTEC NGjzWlNEgXSxdH;4bYNqfHliYYPzZZk> NWnucVIxUUN3MDC9JFAvODByOTFOwG0> MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzFzM{K4PEc,OTdzMUOyPFg9N2F-
Hep3B MYHDfZRwfG:6aXPpeJkh[XO|YYm= M{L5WGlEPTBiPTCwMlAxPTRizszN MkexQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzMUOyPFgoRjF5MUGzNlg5RC:jPh?=
NCI-H226 MoO2R5l1d3SxeHnjbZR6KGG|c3H5 NFzyR|VKSzVyIE2gNE4xODZ6IN88US=> NF\sUos9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{GxN|I5QCd-MUexNVMzQDh:L3G+
A498 NUTlXYJSS3m2b4TvfIlkcXS7IHHzd4F6 MoPTTWM2OCB;IECuNFYyKM7:TR?= NF33V5Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{GxN|I5QCd-MUexNVMzQDh:L3G+
MDA435/LCC6 MXvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M33mdGlEPTBiPTCwMlAxOjlizszN Mn\kQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzNUS1NFUoRjF5MUW0OVA2RC:jPh?=
multidrug resistant MDA435/LCC6 M1rXTGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M3e1S2lEPTBiPTCwMlAxPDhizszN MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF3NEWwOUc,OTdzNUS1NFU9N2F-
P388 NV;OcJdDSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M3XFRWlEPTBiPTCwMlAzOiEQvF2= M{HRUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUW0OVA2Lz5zN{G1OFUxPTxxYU6=
adriamycin resistant P388 NFLBb3lCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MX3JR|UxKD1iMD6wN{DPxE1? NEjGXo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G1OFUxPSd-MUexOVQ2ODV:L3G+
LT12 MVXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MorzOFghcA>? M3z0OGlEPTBiPTCwMlAxPiEQvF2= Ml;0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOEGxOlQoRjF5MUixNVY1RC:jPh?=
SKOV3 MVzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? Mlr3OFghcA>? M3jXXGlEPTBiPTCwMlAyKM7:TR?= MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG2OEc,OTdzOEGxOlQ9N2F-
NCI-H460 M4rEd2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MYW0PEBp NIPYWmlKSzVyIE2gNE4xOSEQvF2= MorqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOEGxOlQoRjF5MUixNVY1RC:jPh?=
SF268 NIjJcYlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MkmxOFghcA>? NE\jSJZKSzVyIE2gNE4xOSEQvF2= NIq4[3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G4NVE3PCd-MUexPFEyPjR:L3G+
RKO NH\ZelVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MVK0PEBp NF7VeYZKSzVyIE2gNE4xOSEQvF2= MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG2OEc,OTdzOEGxOlQ9N2F-
KB/HeLa MYfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M1rUeVQ5KGh? NGXxPXZKSzVyIE2gNE4xOSEQvF2= MofMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOEGxOlQoRjF5MUixNVY1RC:jPh?=
P388 MXTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NEPCSYo1QCCq M1zMWmlEPTBiPTCwMlA1KM7:TR?= NEfMcIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G4NVE3PCd-MUexPFEyPjR:L3G+
L1210 NH;5VopCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MX[0PEBp NXvZPXNKUUN3MDC9JFAvODZizszN NVWzbHh6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPjRpPkG3NVgyOTZ2PD;hQi=>
LT12 MDR Mnv5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NUTJcm9yPDhiaB?= M1LN[WlEPTBiPTCwMlQh|ryP M17YdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVY1Lz5zN{G4NVE3PDxxYU6=
A2780 NEP6fZlEgXSxdH;4bYNqfHliYYPzZZk> M1PpSWlEPTBiPTCwMlAxOSEQvF2= M3TMNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MkC2NVM6Lz5zN{KwOlE{QTxxYU6=
A2780-1A9 Ml\4R5l1d3SxeHnjbZR6KGG|c3H5 MXTJR|UxKD1iMD6wNFEyKM7:TR?= NHfLN3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{KwOlE{QSd-MUeyNFYyOzl:L3G+
A549 MorMR5l1d3SxeHnjbZR6KGG|c3H5 NVT1OGlJUUN3MDC9JFAvODB|NjFOwG0> NH;GcpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{KwOlE{QSd-MUeyNFYyOzl:L3G+
1A9PTX22 Mo\NR5l1d3SxeHnjbZR6KGG|c3H5 Mn;BTWM2OCB;IECuNFE6KM7:TR?= M3X2SFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MkC2NVM6Lz5zN{KwOlE{QTxxYU6=
1A9PTX10 MorwR5l1d3SxeHnjbZR6KGG|c3H5 NX73RXpVUUN3MDC9JFAvODNizszN Ml7wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd{ME[xN|koRjF5MkC2NVM6RC:jPh?=
A2780AD MXjDfZRwfG:6aXPpeJkh[XO|YYm= NWL5R5RnUUN3MDC9JFAvQSEQvF2= MkmzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd{ME[xN|koRjF5MkC2NVM6RC:jPh?=
KB M2DHZWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M2\HU2lEPTBiPTCwMlAxOjR3IN88US=> M3XZUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MkK4PFc{Lz5zN{KyPFg4OzxxYU6=
COLO205 NWfadolFS3m2b4TvfIlkcXS7IHHzd4F6 NUL1UWdlUUN3MDC9JFAvODB|MzFOwG0> NYCyZncyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUeyNlg5PzNpPkG3NlI5QDd|PD;hQi=>
KB8.5 MnHRRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MX7JR|UxKD1iMD6wNlYh|ryP NGLWdlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{KyPFg4Oyd-MUeyNlg5PzN:L3G+
KBV1 NIfRfJJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= Mln0TWM2OCB;IEKuNFE{KM7:TR?= NG[2[3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{KyPFg4Oyd-MUeyNlg5PzN:L3G+
A2780 MlzyR5l1d3SxeHnjbZR6KGG|c3H5 NGPCPGFKSzVyIE2gNE4xODB5IN88US=> MnfxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd{M{m1PVcoRjF5MkO5OVk4RC:jPh?=
2780AD NWjUWVhnS3m2b4TvfIlkcXS7IHHzd4F6 NVPNc4ptUUN3MDC9JFAvPTN3IN88US=> MmDnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd{M{m1PVcoRjF5MkO5OVk4RC:jPh?=
1A9 NY\iVZBYS3m2b4TvfIlkcXS7IHHzd4F6 Mnm4SWQ2OCB;IECuNFAyKM7:TR?= M{PBSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5M{WwPFM1Lz5zN{O1NFg{PDxxYU6=
MCF7 MXXDfZRwfG:6aXPpeJkh[XO|YYm= NEm3T5FGTDVyIE2gNE4xODFzIN88US=> NYX1elVjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUezOVA5OzRpPkG3N|UxQDN2PD;hQi=>
DU145 NUnsW2UyS3m2b4TvfIlkcXS7IHHzd4F6 NVXRSZhOTUR3MDC9JFAvODBzMzFOwG0> NFPpfXo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{O1NFg{PCd-MUezOVA5OzR:L3G+
KB NH;ZVpFEgXSxdH;4bYNqfHliYYPzZZk> NV;lV29rTUR3MDC9JFAvODBzODFOwG0> MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzN3MEizOEc,OTd|NUC4N|Q9N2F-
A549 MWrDfZRwfG:6aXPpeJkh[XO|YYm= NEj4e4ZGTDVyIE2gNE4xODJ|IN88US=> MnjiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd|NUC4N|QoRjF5M{WwPFM1RC:jPh?=
LNCAP NFTCV2JEgXSxdH;4bYNqfHliYYPzZZk> NGX3[5dGTDVyIE2gNE4xODJ4IN88US=> NY\OVHB2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUezOVA5OzRpPkG3N|UxQDN2PD;hQi=>
PC3 NV3NU|F[S3m2b4TvfIlkcXS7IHHzd4F6 NIrtcVRGTDVyIE2gNE4xPTV3IN88US=> Mn3CQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd|NUC4N|QoRjF5M{WwPFM1RC:jPh?=
KBVIN NXrac4xjS3m2b4TvfIlkcXS7IHHzd4F6 NF\iTIdGTDVyIE2gNE4{OTFizszN MlPIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd|NUC4N|QoRjF5M{WwPFM1RC:jPh?=
A2780 MlvnR5l1d3SxeHnjbZR6KGG|c3H5 NFnPfpNKSzVyIE2gNE4xODF4IN88US=> NGToO4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{O5OVQ3PSd-MUezPVU1PjV:L3G+
A2780/AD NEL2b3VEgXSxdH;4bYNqfHliYYPzZZk> M{noTGlEPTBiPTCwMlkzKM7:TR?= NG[4N5M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{O5OVQ3PSd-MUezPVU1PjV:L3G+
KB NXXKZXBVSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M4PW[WlEPTBiPTCwMlAxOjR3IN88US=> M4jRSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEG2OVI1Lz5zN{SxOlUzPDxxYU6=
COLO205 M{XqN2N6fG:2b4jpZ4l1gSCjc4PhfS=> MYHJR|UxKD1iMD6wNFM{KM7:TR?= MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRzNkWyOEc,OTd2MU[1NlQ9N2F-
KB8.5 NHvZV5BCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NIHHTHdKSzVyIE2gNE4xOjZizszN M3O2dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEG2OVI1Lz5zN{SxOlUzPDxxYU6=
KBV1 MWXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M1j2XGlEPTBiPTCyMlAyOyEQvF2= NGKyeXg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{SxOlUzPCd-MUe0NVY2OjR:L3G+
neural precursor MWjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NYLtUVRTTUN3MDC9JFAvODFizszN MnrEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2MUe2N|EoRjF5NEG3OlMyRC:jPh?=
OVCAR-3 MUjDfZRwfG:6aXPpeJkh[XO|YYm= MXPJR|UxKD1iMD6wNFAzKM7:TR?= M2ry[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEG5NFY2Lz5zN{SxPVA3PTxxYU6=
MDA-MB-231 MnTKR5l1d3SxeHnjbZR6KGG|c3H5 M2m1VmlEPTBiPTCwMlAxPDVizszN MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRzOUC2OUc,OTd2MUmwOlU9N2F-
MCF7 NISze3JEgXSxdH;4bYNqfHliYYPzZZk> M1fpW2lEPTBiPTCwMlAxPDlizszN MnjmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2MUmwOlUoRjF5NEG5NFY2RC:jPh?=
NCI-H1299 NFO4VFNEgXSxdH;4bYNqfHliYYPzZZk> MkjWPVYhcA>? NYfIdIxqUUN3MDC9JFAvODF3IN88US=> NXj6V2V1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0NVkxPjVpPkG3OFE6ODZ3PD;hQi=>
A2780 M2fndmN6fG:2b4jpZ4l1gSCjc4PhfS=> NUnkTJZ7UUN3MDC9JFAvODJ3IN88US=> NFfh[XE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{SxPVA3PSd-MUe0NVkxPjV:L3G+
PC3 M4S5bmN6fG:2b4jpZ4l1gSCjc4PhfS=> MlfJTWM2OCB;IECuNFc4KM7:TR?= NVKxXWJ7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0NVkxPjVpPkG3OFE6ODZ3PD;hQi=>
LoVo NWLuXHI2S3m2b4TvfIlkcXS7IHHzd4F6 MULJR|UxKD1iMD6wPUDPxE1? MkXaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2MUmwOlUoRjF5NEG5NFY2RC:jPh?=
L2987 NWXONmRXS3m2b4TvfIlkcXS7IHHzd4F6 NEPvWnJKSzVyIE2gNE4zKM7:TR?= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRzOUC2OUc,OTd2MUmwOlU9N2F-
cells NVPOUHJ{S3m2b4TvfIlkcXS7IHHzd4F6 NV3OcHBXUUN3MDC9JFAvODB3OTFOwG0> MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR2MkW3O{c,OTd2NEK1O|c9N2F-
cells MWjDfZRwfG:6aXPpeJkh[XO|YYm= NVfDXGVzUUN3MDC9JFAvODFizszN MkTwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2OEWyNFcoRjF5NEi1NlA4RC:jPh?=
A2780 MmW3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mkn1TWM2OCB;IECuNFAzQCEQvF2= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR7MEi3PEc,OTd2OUC4O|g9N2F-
VA13 NGHLO3FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mkj6TWM2OCB;IECuNFA2KM7:TR?= MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR7MEi3PEc,OTd2OUC4O|g9N2F-
WI38 MlTnS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXfhOm9mUUN3MDC9JFAvODRizszN MkixQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2OUC4O|goRjF5NEmwPFc5RC:jPh?=
2780AD NWPEUWdUT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWXJR|UxKD1iMD6xPFMh|ryP MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR7MEi3PEc,OTd2OUC4O|g9N2F-
HepG2 MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnH0TWM2OCB;IEiuNUDPxE1? MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR7MEi3PEc,OTd2OUC4O|g9N2F-
HT29 MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkHPOFghcA>? M{f2emdKPTBiPTCwMlAyPSEQvF2= NYfqW3JlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0PVg6PjBpPkG3OFk5QTZyPD;hQi=>
M21 MoXOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnzjOFghcA>? NWHGfG5mT0l3MDC9JFAvODN5IN88US=> M1rEPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEm4PVYxLz5zN{S5PFk3ODxxYU6=
MCF7 NWPEcHJsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXi0PEBp NELDRnhIUTVyIE2gNE4xPTRizszN M{TIdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEm4PVYxLz5zN{S5PFk3ODxxYU6=
1A9 NGLCd41Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVO3NkBp M1\GWWdKPTBiPTCwMlAxODdzIN88US=> MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV2MkW3Nkc,OTd3NEK1O|I9N2F-
1A9/Ptx22 M2LLTWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWHkTWc{PzJiaB?= NILvUHJIUTVyIE2gNE4xPTFizszN NFX4d|c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W0NlU4Oid-MUe1OFI2PzJ:L3G+
1A9/Ptx10 MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NILJfo84OiCq MVHHTVUxKD1iMD6wOlQh|ryP MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV2MkW3Nkc,OTd3NEK1O|I9N2F-
cells expressing MRP1 NVHqRm4yT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF\EeYxKSzVyIE2gNE4xODJ3IN88US=> MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV4N{GyNUc,OTd3NkexNlE9N2F-
cells expressing Pgp/MRP1 MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWDL[pV4UUN3MDC9JFIvPyEQvF2= NVHXbYRoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OlcyOjFpPkG3OVY4OTJzPD;hQi=>
VA13 NUjL[YF5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mo\4TWM2OCB;IEWg{txO MnS5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3OUWxN|QoRjF5NUm1NVM1RC:jPh?=
MCF7 MWDGeY5kfGmxbjDhd5NigQ>? MnHETWM2OCB;IECuNFAyQCEQvF2= NYS1clJ{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2NFE4OzlpPkG3OlAyPzN7PD;hQi=>
adriamycin-resistant MCF7 NIfONIlHfW6ldHnvckBie3OjeR?= NX3rNml3UUN3MDC9JFgvOiEQvF2= NX3YcVc6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2NFE4OzlpPkG3OlAyPzN7PD;hQi=>
RPMI8226 Ml;uR5l1d3SxeHnjbZR6KGG|c3H5 MYLHTVUxKD1iMD6wNFIh|ryP NYjXV4xzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2PVY{OzJpPkG3Olk3OzN{PD;hQi=>
HT29 NXvycWdtS3m2b4TvfIlkcXS7IHHzd4F6 MnWyS2k2OCB;IECuNFAzKM7:TR?= NVXoV5RRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2PVY{OzJpPkG3Olk3OzN{PD;hQi=>
COLO205 NXjIUHFtS3m2b4TvfIlkcXS7IHHzd4F6 MkPDS2k2OCB;IECuNFA{KM7:TR?= NIP4VpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[5OlM{Oid-MUe2PVY{OzJ:L3G+
HCC2998 NUfPXIVKS3m2b4TvfIlkcXS7IHHzd4F6 MYPHTVUxKD1iMD6wNFMh|ryP MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ7NkOzNkc,OTd4OU[zN|I9N2F-
HS578T NYDRd5V6S3m2b4TvfIlkcXS7IHHzd4F6 NX;3TXRyT0l3MDC9JFAvODB|IN88US=> Ml;HQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4OU[zN|IoRjF5Nkm2N|MzRC:jPh?=
PC3 M2fmcWN6fG:2b4jpZ4l1gSCjc4PhfS=> M3T4OmdKPTBiPTCwMlAxPCEQvF2= MlPkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4OU[zN|IoRjF5Nkm2N|MzRC:jPh?=
SNB75 NInJWY5EgXSxdH;4bYNqfHliYYPzZZk> MUDHTVUxKD1iMD6wNFQh|ryP M2r4N|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Nkm2N|MzLz5zN{[5OlM{OjxxYU6=
A549 MUfDfZRwfG:6aXPpeJkh[XO|YYm= NH7IeoxIUTVyIE2gNE4xODRizszN MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ7NkOzNkc,OTd4OU[zN|I9N2F-
KM12 NVK4UZg{S3m2b4TvfIlkcXS7IHHzd4F6 M4\6UWdKPTBiPTCwMlAxPCEQvF2= MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ7NkOzNkc,OTd4OU[zN|I9N2F-
DU145 NV36b2duS3m2b4TvfIlkcXS7IHHzd4F6 MVzHTVUxKD1iMD6wNFUh|ryP NVzaeWlbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2PVY{OzJpPkG3Olk3OzN{PD;hQi=>
SK-OV3 NUXOO5FqS3m2b4TvfIlkcXS7IHHzd4F6 NF\JSHlIUTVyIE2gNE4xODhizszN M1rDR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Nkm2N|MzLz5zN{[5OlM{OjxxYU6=
NCI-H322M Mo\3R5l1d3SxeHnjbZR6KGG|c3H5 MlyyS2k2OCB;IECuNFE{KM7:TR?= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ7NkOzNkc,OTd4OU[zN|I9N2F-
UACC257 Mm[1R5l1d3SxeHnjbZR6KGG|c3H5 M3z3e2dKPTBiPTCwMlA1KM7:TR?= NF:4N4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[5OlM{Oid-MUe2PVY{OzJ:L3G+
HCT15 Ml:0R5l1d3SxeHnjbZR6KGG|c3H5 NEDwTYpIUTVyIE2gNE4yPThizszN NYn6dnlSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2PVY{OzJpPkG3Olk3OzN{PD;hQi=>
ACHN MYTDfZRwfG:6aXPpeJkh[XO|YYm= M{P6O2dKPTBiPTCwMlM6QCEQvF2= MkPXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4OU[zN|IoRjF5Nkm2N|MzRC:jPh?=
HeLa NYDQWI5WS3m2b4TvfIlkcXS7IHHzd4F6 MljyTWM2OCB;IECuNFA2PiEQvF2= MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzd4NEG0PEc,OTd5NkSxOFg9N2F-
MCF7 MnK2R5l1d3SxeHnjbZR6KGG|c3H5 NYnHemFvUUN3MDC9JFAvODF{NDFOwG0> MnfQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd5NkSxOFgoRjF5N{[0NVQ5RC:jPh?=
A549 MXjDfZRwfG:6aXPpeJkh[XO|YYm= M2XYPWlEPTBiPTCwMlAyOjZizszN NE\nWpk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{e2OFE1QCd-MUe3OlQyPDh:L3G+
HGC27 NYPFdlg{S3m2b4TvfIlkcXS7IHHzd4F6 NX7FTmVtUUN3MDC9JFAvPzd5ODFOwG0> NYPtT2h2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe3OlQyPDhpPkG3O|Y1OTR6PD;hQi=>
HL60 MWLDfZRwfG:6aXPpeJkh[XO|YYm= MXm3NkBp NHTFN45KSzVyIE2gNE46OyEQvF2= Mm\sQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd6OU[4NVYoRjF5OEm2PFE3RC:jPh?=
P388 NXzOZXdUS3m2b4TvfIlkcXS7IHHzd4F6 M4[wNVczKGh? NUHtTlJNUUN3MDC9JFAvQTNizszN M4fZSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OEm2PFE3Lz5zN{i5OlgyPjxxYU6=
BEL-7402 NFjEdI9EgXSxdH;4bYNqfHliYYPzZZk> M2q3R|I1KGh? MUjJR|UxKD1iMD65N{DPxE1? NVLMc41NRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe4PVY5OTZpPkG3PFk3QDF4PD;hQi=>
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HepG2 NWeyWXdtS3m2b4TvfIlkcXS7IHHzd4F6 NELaW2ZKSzVyIE2gNE45OiEQvF2= NUnLTJlSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5NVExOTdpPkG3PVEyODF5PD;hQi=>
BGC823 MVfDfZRwfG:6aXPpeJkh[XO|YYm= M4\GUmlEPTBiPTCxMlE2KM7:TR?= MnnoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7MUGwNVcoRjF5OUGxNFE4RC:jPh?=
Aro MWXDfZRwfG:6aXPpeJkh[XO|YYm= MmDOO|IhcA>? NUnCT5FpUUN3MDC9JFAvODByMjFOwG0> M16xV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OUG1PFUyLz5zN{mxOVg2OTxxYU6=
PT45 MX;DfZRwfG:6aXPpeJkh[XO|YYm= NGG4c3Q4OiCq MkWzTWM2OCB;IECuNFA2KM7:TR?= MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzlzNUi1NUc,OTd7MUW4OVE9N2F-
A549 M1vFVWN6fG:2b4jpZ4l1gSCjc4PhfS=> MmrxO|IhcA>? M2LFSGlEPTBiPTCwMlAxPiEQvF2= NXzIeWpQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5NVU5PTFpPkG3PVE2QDVzPD;hQi=>
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Ovcar3 MmTZR5l1d3SxeHnjbZR6KGG|c3H5 NV7McJpZPzJiaB?= NWfWSXdJUUN3MDC9JFAvODFizszN NX7jSmJ{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5NVU5PTFpPkG3PVE2QDVzPD;hQi=>
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HepG2 NGnHTGhEgXSxdH;4bYNqfHliYYPzZZk> NFTJe2E4OiCq M1;CVGlEPTBiPTCwMlMh|ryP M4HyXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OUG1PFUyLz5zN{mxOVg2OTxxYU6=
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L12 M{PHXWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MnnzOFghcA>? M{WycGlEPTBiPTCwMlAxPiEQvF2= NGPPc4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{m3N|M3OSd-MUe5O|M{PjF:L3G+
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SF268 NIXCc4ZEgXSxdH;4bYNqfHliYYPzZZk> MUm0PEBp MoT4TWM2OCB;IECuNFEh|ryP MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzl5M{O2NUc,OTd7N{OzOlE9N2F-
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cells assessed as accumulation at G2/M phase after 24 hrs by flow cytometric analysis MYXD[YxtKGO7Y3zlJIFzemW|dDDhd5NigQ>? MlfDSWM2OCB;IECuNFQ6KM7:TR?= NVnvZpBQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5O|M{PjFpPkG3PVc{OzZzPD;hQi=>
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cells after 48 hrs by XTT assay M3vie2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MmSxTWM2OCB;IECuOEDPxE1? NFzwZXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{m3N|M3OSd-MUe5O|M{PjF:L3G+
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HCT8 NVH4cnJKS3m2b4TvfIlkcXS7IHHzd4F6 NV7NOWl2UUN3MDC9JFAvODN5IN88US=> MomyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOThyMEGwPFcoRjF6MECxNFg4RC:jPh?=
Bel7402 MoS5R5l1d3SxeHnjbZR6KGG|c3H5 MWPJR|UxKD1iMD6xJO69VQ>? Mn;yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOThyMEGwPFcoRjF6MECxNFg4RC:jPh?=
cells by alamar blue assay MUfGeY5kfGmxbjDhd5NigQ>? MlTxTWM2OCB;IECuNFQh|ryP M{XqbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6MEewPVY2Lz5zOEC3NFk3PTxxYU6=
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MDA435 Ml22R5l1d3SxeHnjbZR6KGG|c3H5 NF;3cm04OiCq M{fGOWlEPTBiPTCwMlAxPSEQvF2= MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDNyOEW2Okc,OTh|MEi1OlY9N2F-
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MESSA/DX5 Mn\vR5l1d3SxeHnjbZR6KGG|c3H5 NFLFN3U4OiCq MnPGTWM2OCB;IEWg{txO NYja[oRkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNFg2PjZpPkG4N|A5PTZ4PD;hQi=>
K562 NYO3SGJTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmLYO|IhcA>? MXfJR|UxKD1iMD6wNFA3KM7:TR?= NX7MR4dsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNVM{ODdpPkG4N|E{OzB5PD;hQi=>
KB3-1 NUiwbVdTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHf4SVg4OiCq NXPS[ms4UUN3MDC9JFAvODB{IN88US=> NYqyU|A2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNVM{ODdpPkG4N|E{OzB5PD;hQi=>
HepG2 NHfYUHdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGLs[2Q4OiCq Mn;ITWM2OCB;IECuNFA4KM7:TR?= Mk\vQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh|MUOzNFcoRjF6M{GzN|A4RC:jPh?=
KB V1 MkHtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXe1RZEyPzJiaB?= MXnJR|UxKD1iODFOwG0> MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDNzM{OwO{c,OTh|MUOzNFc9N2F-
A549 NGXpcIdEgXSxdH;4bYNqfHliYYPzZZk> M4XPU|Mh\GG7cx?= NIrIZm1KSzVyIE2gNE4xODdizszN NGLxPYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOESxPVE2PCd-MUi0NVkyPTR:L3G+
MCF7 MU\DfZRwfG:6aXPpeJkh[XO|YYm= M3\URlMh\GG7cx?= M17tVGlEPTBiPTCwMlAyOTdizszN NXmxSXN4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0NVkyPTRpPkG4OFE6OTV2PD;hQi=>
HepG2 MYXDfZRwfG:6aXPpeJkh[XO|YYm= MmPwN{Bl[Xm| NILqb2lKSzVyIE2gNE4xPDZ6IN88US=> MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDRzOUG1OEc,OTh2MUmxOVQ9N2F-
MDA-MB-231 MVfDfZRwfG:6aXPpeJkh[XO|YYm= NHvRSVM{KGSjeYO= MojHTWM2OCB;IECuNFcxOyEQvF2= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDRzOUG1OEc,OTh2MUmxOVQ9N2F-
Hep3B