Autophagy

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1013 Bortezomib (PS-341) <1 mg/mL 76 mg/mL '<1 mg/mL
S3239 Emetine Dihydrochloride -1 mg/mL 100 mg/mL '''-1 mg/mL
S3233 Emetine hydrochloride -1 mg/mL 100 mg/mL '''-1 mg/mL
S6847 ML-9 HCl 10 mg/mL 72 mg/mL '''6 mg/mL
S6851 RA-190 <1 mg/mL 100 mg/mL '''20 mg/mL
S8943 VLX600 ˂1 mg/mL 13 mg/mL ˂1 mg/mL
S0709 Tubastatin A TFA 5 mg/mL 40 mg/mL ''<1 mg/mL
S6716 NSC 185058 <1 mg/mL 43 mg/mL 21 mg/mL
S1109 BI 2536 <1 mg/mL 21 mg/mL '100 mg/mL
S1105 LY294002 <1 mg/mL 36 mg/mL '21 mg/mL
S1092 KU-55933 (ATM Kinase Inhibitor) <1 mg/mL 33 mg/mL ''<1 mg/mL
S1102 U0126-EtOH <1 mg/mL 85 mg/mL ''<1 mg/mL
S1150 Paclitaxel <1 mg/mL 171 mg/mL ''18 mg/mL
S1460 SP600125 <1 mg/mL 44 mg/mL '''<1 mg/mL
S1490 Ponatinib (AP24534) <1 mg/mL 30 mg/mL '<1 mg/mL
S1113 GSK690693 <1 mg/mL 39 mg/mL ''<1 mg/mL
S2758 Wortmannin <1 mg/mL 85 mg/mL '<1 mg/mL
S2704 LY2109761 <1 mg/mL 2 mg/mL '<1 mg/mL
S2767 3-Methyladenine (3-MA) 10 mg/mL 3 mg/mL ''4 mg/mL
S2243 Degrasyn (WP1130) <1 mg/mL 77 mg/mL '18 mg/mL
S1786 Verteporfin <1 mg/mL 100 mg/mL ''''<1 mg/mL
S7046 Brefeldin A <1 mg/mL 4 mg/mL '<1 mg/mL
S8037 Necrostatin-1 <1 mg/mL 51 mg/mL ''''<1 mg/mL
S2775 Nocodazole <1 mg/mL 7 mg/mL '''<1 mg/mL
S3042 Purmorphamine <1 mg/mL 4 mg/mL '<1 mg/mL
S1346 Heparin sodium 100 mg/mL <1 mg/mL ''<1 mg/mL
S4157 Chloroquine diphosphate 100 mg/mL <1 mg/mL '''<1 mg/mL
S7033 GSK2656157 <1 mg/mL 32 mg/mL '<1 mg/mL
S1733 Methylprednisolone <1 mg/mL 75 mg/mL '''''2 mg/mL
S1413 Bafilomycin A1(Baf-A1) <1 mg/mL 6 mg/mL '<1 mg/mL
S1835 Azithromycin <1 mg/mL 100 mg/mL '100 mg/mL
S2930 Pifithrin-μ <1 mg/mL 36 mg/mL ''36 mg/mL
S8808 DC661 <1 mg/mL 62 mg/mL '49 mg/mL
S7289 PFK15 <1 mg/mL 19 mg/mL ''2 mg/mL
S7885 SBI-0206965 <1 mg/mL 97 mg/mL ''10 mg/mL
S8576 EAD1 100 mg/mL 100 mg/mL 100 mg/mL
S8274 STO-609 <1 mg/mL 8 mg/mL '<1 mg/mL
S8764 IITZ-01 <1 mg/mL 100 mg/mL <1 mg/mL
S7888 Spautin-1 <1 mg/mL 54 mg/mL ''7 mg/mL
S8317 3BDO <1 mg/mL 65 mg/mL ''49 mg/mL
S7811 MHY1485 <1 mg/mL 4 mg/mL <1 mg/mL
S8596 Autophinib <1 mg/mL 69 mg/mL <1 mg/mL
S7423 KN-93 Phosphate 92 mg/mL 100 mg/mL '<1 mg/mL
S8807 PFK158 ˂1 mg/mL 14 mg/mL '4 mg/mL
S3758 Sinomenine hydrochloride -1 mg/mL 73 mg/mL -1 mg/mL
S7948 MRT67307 HCl 92 mg/mL 92 mg/mL '''92 mg/mL
S8369 Lys05 3 mg/mL 9 mg/mL <1 mg/mL
S7455 Resatorvid (TAK-242) <1 mg/mL 72 mg/mL '''72 mg/mL
S7660 Obeticholic Acid <1 mg/mL 84 mg/mL '84 mg/mL
S7146 DMH1 <1 mg/mL 22 mg/mL '<1 mg/mL
S4430 Hydroxychloroquine Sulfate 67 mg/mL <1 mg/mL ''<1 mg/mL
S7949 MRT68921 HCl <1 mg/mL <1 mg/mL '<1 mg/mL
S8744 PHY34 <1 mg/mL 100 mg/mL 42 mg/mL
S5920 CA-5f <1 mg/mL 78 mg/mL <1 mg/mL
S8222 AS1842856 <1 mg/mL 23 mg/mL '''<1 mg/mL
S7682 SAR405 <1 mg/mL 88 mg/mL ''88 mg/mL
S7683 PIK-III <1 mg/mL 63 mg/mL ''63 mg/mL
S8793 ULK-101 <1 mg/mL 92 mg/mL '''<1 mg/mL
S8527 ROC-325 <1 mg/mL 4 mg/mL 4 mg/mL
S9424 Liensinine diperchlorate -1 mg/mL 50 mg/mL -1 mg/mL
S6471 Lucanthone <1 mg/mL 33 mg/mL 68 mg/mL
S7751 VER155008 <1 mg/mL 100 mg/mL '<1 mg/mL
S9150 Daurisoline -1 mg/mL 64 mg/mL -1 mg/mL
S7381 Pepstatin A <1 mg/mL 57 mg/mL ''1 mg/mL
S1078 MK-2206 2HCl <1 mg/mL 14 mg/mL <1 mg/mL
S1060 Olaparib (AZD2281) 0.002 mg/mL 86 mg/mL <1 mg/mL
S1267 Vemurafenib (PLX4032) <1 mg/mL 97 mg/mL <1 mg/mL
S1047 Vorinostat (SAHA) <1 mg/mL 52 mg/mL ''3 mg/mL
S6797 QX77 <1 mg/mL 60 mg/mL <1 mg/mL
S6650 EN6 <1 mg/mL 74 mg/mL <1 mg/mL
S1002 ABT-737 <1 mg/mL 100 mg/mL '<1 mg/mL
S1049 Y-27632 2HCl 14 mg/mL 64 mg/mL '<1 mg/mL
S2619 MG-132 <1 mg/mL 90 mg/mL ''25 mg/mL
S1009 Dactolisib (BEZ235) <1 mg/mL 0.01 mg/mL '<1 mg/mL
S1040 Sorafenib Tosylate 0.01 mg/mL 127 mg/mL ''''<1 mg/mL
S1021 Dasatinib <1 mg/mL 98 mg/mL '<1 mg/mL
S1039 Rapamycin (Sirolimus) <1 mg/mL 20 mg/mL ''<1 mg/mL
S1068 Crizotinib (PF-02341066) <1 mg/mL 9 mg/mL '<1 mg/mL
S1023 Erlotinib HCl (OSI-744) <1 mg/mL 4 mg/mL '''<1 mg/mL
S1120 Everolimus (RAD001) <1 mg/mL 100 mg/mL 7 mg/mL
S1025 Gefitinib (ZD1839) <1 mg/mL 89 mg/mL '''4 mg/mL
S1004 Veliparib (ABT-888) <1 mg/mL 17 mg/mL '''<1 mg/mL
S1053 Entinostat (MS-275) <1 mg/mL 75 mg/mL '''<1 mg/mL
S1065 Pictilisib (GDC-0941) <1 mg/mL 44 mg/mL ''<1 mg/mL
S1378 Ruxolitinib (INCB018424) <1 mg/mL 61 mg/mL 61 mg/mL
S1030 Panobinostat (LBH589) <1 mg/mL 69 mg/mL ''<1 mg/mL
S1026 Imatinib Mesylate (STI571) 118 mg/mL 118 mg/mL '''<1 mg/mL
S1250 Enzalutamide (MDV3100) <1 mg/mL 92 mg/mL '<1 mg/mL
S1133 Alisertib (MLN8237) <1 mg/mL 27 mg/mL <1 mg/mL
S1011 Afatinib (BIBW2992) <1 mg/mL 97 mg/mL ''15 mg/mL
S2226 Idelalisib (CAL-101, GS-1101) <1 mg/mL 83 mg/mL '23 mg/mL
S1048 Tozasertib (VX-680, MK-0457) <1 mg/mL 93 mg/mL '<1 mg/mL
S1555 AZD8055 <1 mg/mL 50 mg/mL '3 mg/mL
S1006 Saracatinib (AZD0530) <1 mg/mL 35 mg/mL '31 mg/mL
S1057 Obatoclax Mesylate (GX15-070) <1 mg/mL 83 mg/mL <1 mg/mL
S1141 Tanespimycin (17-AAG) <1 mg/mL 100 mg/mL '''5 mg/mL
S1130 YM155 (Sepantronium Bromide) 89 mg/mL 55 mg/mL '6 mg/mL
S1166 Cisplatin <1 mg/mL 60 mg/mL '''''<1 mg/mL
S2475 Imatinib (STI571) <1 mg/mL 33 mg/mL ''<1 mg/mL
S1033 Nilotinib (AMN-107) <1 mg/mL 27 mg/mL '<1 mg/mL
S1044 Temsirolimus (CCI-779) <1 mg/mL 67 mg/mL '75 mg/mL
S1038 PI-103 <1 mg/mL 24 mg/mL '<1 mg/mL
S1069 Luminespib (NVP-AUY922) <1 mg/mL 93 mg/mL ''31 mg/mL
S1046 Vandetanib (ZD6474) <1 mg/mL 4 mg/mL '''''<1 mg/mL
S1149 Gemcitabine HCl 19 mg/mL <1 mg/mL '''<1 mg/mL
S1122 Mocetinostat (MGCD0103) <1 mg/mL 13 mg/mL ''<1 mg/mL
S1178 Regorafenib (BAY 73-4506) <1 mg/mL 97 mg/mL '''<1 mg/mL
S1129 SRT1720 HCl <1 mg/mL 38 mg/mL '<1 mg/mL
S1035 Pazopanib HCl (GW786034 HCl) <1 mg/mL 17 mg/mL '<1 mg/mL
S1014 Bosutinib (SKI-606) <1 mg/mL 100 mg/mL ''''2 mg/mL
S1017 Cediranib (AZD2171) <1 mg/mL 90 mg/mL ''<1 mg/mL
S1085 Belinostat (PXD101) <1 mg/mL 64 mg/mL '''<1 mg/mL
S1077 SB202190 (FHPI) <1 mg/mL 66 mg/mL '12 mg/mL
S2853 Carfilzomib (PR-171) <1 mg/mL 50 mg/mL ''<1 mg/mL
S1191 Fulvestrant <1 mg/mL 100 mg/mL ''100 mg/mL
S1075 SB216763 <1 mg/mL 23 mg/mL ''<1 mg/mL
S1080 SU11274 <1 mg/mL 92 mg/mL ''2 mg/mL
S1003 Linifanib (ABT-869) <1 mg/mL 75 mg/mL '''<1 mg/mL
S1135 Pemetrexed 94 mg/mL <1 mg/mL '<1 mg/mL
S2218 Torkinib (PP242) <1 mg/mL 61 mg/mL '18 mg/mL
S1225 Etoposide <1 mg/mL 100 mg/mL ''''<1 mg/mL
S1107 Danusertib (PHA-739358) <1 mg/mL 95 mg/mL '''<1 mg/mL
S2248 Silmitasertib (CX-4945) <1 mg/mL 16 mg/mL '<1 mg/mL
S8048 Venetoclax (ABT-199) <1 mg/mL 100 mg/mL <1 mg/mL
S1230 Flavopiridol (Alvocidib) <1 mg/mL 15 mg/mL '8 mg/mL
S2198 SGI-1776 free base <1 mg/mL 81 mg/mL '81 mg/mL
S2111 Lapatinib <1 mg/mL 100 mg/mL '<1 mg/mL
S1237 Temozolomide <1 mg/mL 38 mg/mL ''<1 mg/mL
S1190 Bicalutamide <1 mg/mL 86 mg/mL ''5 mg/mL
S5003 Tacrolimus (FK506) <1 mg/mL 94 mg/mL '''83 mg/mL
S1950 Metformin HCl 33 mg/mL <1 mg/mL '<1 mg/mL
S1573 Fasudil (HA-1077) HCl 65 mg/mL 5 mg/mL ''<1 mg/mL
S1224 Oxaliplatin 3 mg/mL -1 mg/mL ''''0.01 mg/mL
S2626 Rabusertib (LY2603618) <1 mg/mL 13 mg/mL '''<1 mg/mL
S2679 Flavopiridol HCl <1 mg/mL 88 mg/mL ''<1 mg/mL
S7110 (+)-JQ1 <1 mg/mL 91 mg/mL 91 mg/mL
S1314 Zoledronic Acid <1 mg/mL 0.004 mg/mL ''''<1 mg/mL
S2219 Momelotinib (CYT387) <1 mg/mL 74 mg/mL '<1 mg/mL
S2181 Ixazomib Citrate (MLN9708) <1 mg/mL 100 mg/mL '<1 mg/mL
S1972 Tamoxifen Citrate <1 mg/mL 100 mg/mL ''100 mg/mL
S1235 Letrozole <1 mg/mL 57 mg/mL '<1 mg/mL
S1231 Topotecan HCl 91 mg/mL 91 mg/mL '''<1 mg/mL
S2827 Torin 1 <1 mg/mL 2 mg/mL <1 mg/mL
S2658 Omipalisib (GSK2126458) <1 mg/mL 100 mg/mL '<1 mg/mL
S1233 2-Methoxyestradiol (2-MeOE2) <1 mg/mL 60 mg/mL '''<1 mg/mL
S1782 Azacitidine (5-Azacytidine) <1 mg/mL 48 mg/mL '''''<1 mg/mL
S2624 OSI-027 <1 mg/mL 18 mg/mL '<1 mg/mL
S2180 Ixazomib (MLN2238) <1 mg/mL 72 mg/mL ''9 mg/mL
S1590 TWS119 <1 mg/mL 64 mg/mL '<1 mg/mL
S2696 Apitolisib (GDC-0980) <1 mg/mL 20 mg/mL '<1 mg/mL
S2843 BI-D1870 <1 mg/mL 78 mg/mL ''<1 mg/mL
S1396 Resveratrol <1 mg/mL 45 mg/mL ''<1 mg/mL
S1322 Dexamethasone <1 mg/mL 79 mg/mL '''6 mg/mL
S1648 Cytarabine 48 mg/mL 1 mg/mL '''''<1 mg/mL
S1792 Simvastatin <1 mg/mL 83 mg/mL ''83 mg/mL
S2783 Vistusertib (AZD2014) <1 mg/mL 38 mg/mL '<1 mg/mL
S2635 CCT128930 <1 mg/mL 68 mg/mL ''6 mg/mL
S1228 Idarubicin HCl 5 mg/mL 100 mg/mL ''<1 mg/mL
S1714 Gemcitabine 52 mg/mL 52 mg/mL ''<1 mg/mL
S2163 PF-4708671 <1 mg/mL 30 mg/mL 8 mg/mL
S2817 Torin 2 <1 mg/mL 20 mg/mL ''''<1 mg/mL
S1312 Streptozotocin (STZ) 53 mg/mL 53 mg/mL ''<1 mg/mL
S1582 H 89 2HCl 6 mg/mL 104 mg/mL ''<1 mg/mL
S2713 Geldanamycin <1 mg/mL 36 mg/mL ''<1 mg/mL
S2770 MK-5108 (VX-689) <1 mg/mL 92 mg/mL '<1 mg/mL
S2449 Colforsin (Forskolin) <1 mg/mL 82 mg/mL '''37 mg/mL
S1168 Valproic acid sodium salt (Sodium valproate) 33 mg/mL 33 mg/mL '33 mg/mL
S1759 Pitavastatin Calcium <1 mg/mL 51 mg/mL '''<1 mg/mL
S7306 Dorsomorphin (Compound C) 2HCl 94 mg/mL <1 mg/mL ''<1 mg/mL
S2061 Lovastatin <1 mg/mL 8 mg/mL ''6 mg/mL
S2505 Rosiglitazone maleate <1 mg/mL 94 mg/mL ''<1 mg/mL
S3012 Pazopanib <1 mg/mL 87 mg/mL '''<1 mg/mL
S2799 Daporinad (FK866, APO866) <1 mg/mL <1 mg/mL '78 mg/mL
S1218 Clofarabine <1 mg/mL 60 mg/mL ''<1 mg/mL
S3022 Cabazitaxel <1 mg/mL 100 mg/mL '''''<1 mg/mL
S2077 Atorvastatin Calcium <1 mg/mL 100 mg/mL '<1 mg/mL
S2812 AT101 <1 mg/mL 116 mg/mL '89 mg/mL
S2929 Pifithrin-α (PFTα) HBr <1 mg/mL 67 mg/mL '<1 mg/mL
S4908 SN-38 <1 mg/mL 21 mg/mL '<1 mg/mL
S7164 GSK343 <1 mg/mL 1 mg/mL '4 mg/mL
S8006 BIX 01294 98 mg/mL 98 mg/mL '8 mg/mL
S8059 Nutlin-3a <1 mg/mL 100 mg/mL '100 mg/mL
S1403 Tigecycline 100 mg/mL 100 mg/mL ''<1 mg/mL
S7007 Binimetinib (MEK162) <1 mg/mL 88 mg/mL '<1 mg/mL
S2476 Itraconazole <1 mg/mL 7 mg/mL ''''<1 mg/mL
S2751 Milciclib (PHA-848125) <1 mg/mL 92 mg/mL '<1 mg/mL
S7397 Sorafenib <1 mg/mL 63 mg/mL '''''''<1 mg/mL
S2556 Rosiglitazone <1 mg/mL 71 mg/mL ''<1 mg/mL
S1219 YM201636 <1 mg/mL 35 mg/mL ''<1 mg/mL
S7152 C646 <1 mg/mL 13 mg/mL '<1 mg/mL
S1896 Hydroxyurea 15 mg/mL 15 mg/mL ''<1 mg/mL
S8078 Bardoxolone Methyl <1 mg/mL 21 mg/mL ''''<1 mg/mL
S1999 Sodium butyrate 22 mg/mL <1 mg/mL ''22 mg/mL
S2606 Mifepristone <1 mg/mL 85 mg/mL ''19 mg/mL
S1847 Clemastine Fumarate <1 mg/mL 35 mg/mL ''<1 mg/mL
S7130 PR-619 <1 mg/mL 45 mg/mL '<1 mg/mL
S2782 GW4064 <1 mg/mL 100 mg/mL '<1 mg/mL
S3031 Linagliptin <1 mg/mL 17 mg/mL '1 mg/mL
S3030 Niclosamide <1 mg/mL <1 mg/mL <1 mg/mL
S7165 UNC1999 <1 mg/mL 20 mg/mL ''50 mg/mL
S8047 Dynasore <1 mg/mL 64 mg/mL '<1 mg/mL
S1848 Curcumin <1 mg/mL 73 mg/mL ''<1 mg/mL
S1290 Celastrol <1 mg/mL 90 mg/mL '''<1 mg/mL
S2310 Honokiol <1 mg/mL 53 mg/mL '<1 mg/mL
S1263 CHIR-99021 (CT99021) <1 mg/mL 10 mg/mL <1 mg/mL
S1351 Ivermectin <1 mg/mL 100 mg/mL '''28 mg/mL
S8075 GANT61 <1 mg/mL <1 mg/mL '12 mg/mL
S1389 Omeprazole <1 mg/mL 69 mg/mL 13 mg/mL
S1979 Amiodarone HCl <1 mg/mL 23 mg/mL 11 mg/mL
S2480 Loperamide HCl <1 mg/mL 22 mg/mL 4 mg/mL
S4028 Dexamethasone Sodium Phosphate 103 mg/mL <1 mg/mL <1 mg/mL
S3017 Aspirin <1 mg/mL 36 mg/mL ''36 mg/mL
S7106 AZD3463 <1 mg/mL 24 mg/mL '<1 mg/mL
S1693 Carbamazepine <1 mg/mL 47 mg/mL '18 mg/mL
S2458 Clonidine HCl 53 mg/mL 53 mg/mL 53 mg/mL
S1837 Flubendazole <1 mg/mL 3 mg/mL <1 mg/mL
S1747 Nimodipine <1 mg/mL 84 mg/mL '84 mg/mL
S7134 IU1 <1 mg/mL 60 mg/mL '60 mg/mL
S1576 Sulfasalazine <1 mg/mL 80 mg/mL ''''<1 mg/mL
S7067 Tepotinib (EMD 1214063) <1 mg/mL 5 mg/mL ''<1 mg/mL
S1794 Fenofibrate <1 mg/mL 72 mg/mL ''46 mg/mL
S7177 PF-543 <1 mg/mL 93 mg/mL ''93 mg/mL
S8049 Tubastatin A <1 mg/mL 67 mg/mL '<1 mg/mL
S2491 Nitrendipine <1 mg/mL 72 mg/mL <1 mg/mL
S4211 Montelukast Sodium 100 mg/mL 100 mg/mL ''100 mg/mL
S3984 Nordihydroguaiaretic acid (NDGA) <1 mg/mL 60 mg/mL 60 mg/mL
S7684 Salirasib ' mg/mL
S5243 Ruxolitinib Phosphate 29 mg/mL 80 mg/mL ''8 mg/mL
S7998 Entrectinib (RXDX-101) <1 mg/mL 100 mg/mL '''75 mg/mL
S7781 Sunitinib <1 mg/mL 25 mg/mL '''<1 mg/mL
S3944 Valproic acid (VPA) ' mg/mL
S7343 URMC-099 <1 mg/mL 84 mg/mL '6 mg/mL
S7786 Erlotinib <1 mg/mL 78 mg/mL '15 mg/mL
S7724 APR-246 (PRIMA-1MET) 40 mg/mL 40 mg/mL '40 mg/mL
S8595 Tat-beclin 1 (Tat-BECN1) 100 mg/mL -1 mg/mL -1 mg/mL
S7785 Pemetrexed Disodium Hydrate 100 mg/mL <1 mg/mL ''<1 mg/mL
S5715 atorvastatin -1 mg/mL 100 mg/mL '-1 mg/mL
S2391 Quercetin <1 mg/mL 61 mg/mL 10 mg/mL
S7810 Afatinib (BIBW2992) Dimaleate <1 mg/mL 100 mg/mL ''<1 mg/mL
S2285 Cryptotanshinone <1 mg/mL 5 mg/mL 1 mg/mL
S2290 Dihydroartemisinin (DHA) <1 mg/mL 56 mg/mL 11 mg/mL
S7655 CB-839(Telaglenastat) <1 mg/mL 100 mg/mL <1 mg/mL
S7793 Purvalanol A <1 mg/mL 60 mg/mL '13 mg/mL
S7409 Anisomycin <1 mg/mL 41 mg/mL '17 mg/mL
S3653 Spermidine trihydrochloride 50 mg/mL 30 mg/mL <1 mg/mL
S7648 OTS964 <1 mg/mL 85 mg/mL '1 mg/mL
S8432 Troglitazone (CS-045) <1 mg/mL 88 mg/mL ''15 mg/mL
S9027 Corynoxine <1 mg/mL 77 mg/mL 77 mg/mL
S4081 Sulfacetamide Sodium 51 mg/mL 19 mg/mL <1 mg/mL
S4269 Vinorelbine Tartrate 100 mg/mL 100 mg/mL '100 mg/mL
S7483 DMOG 35 mg/mL 35 mg/mL '35 mg/mL
S8240 SMER28 <1 mg/mL 52 mg/mL 52 mg/mL
S4505 Vinblastine sulfate <1 mg/mL 100 mg/mL ''<1 mg/mL
S7680 SP2509 <1 mg/mL 38 mg/mL '<1 mg/mL
S7104 AZD1208 <1 mg/mL 75 mg/mL ''<1 mg/mL
S7842 LY3009120 <1 mg/mL 3 mg/mL '<1 mg/mL
S4546 Xylitol 30 mg/mL 30 mg/mL <1 mg/mL
S7840 Dorsomorphin (Compound C) <1 mg/mL 1 mg/mL ''2 mg/mL
S9310 Isorhychophylline -1 mg/mL 77 mg/mL -1 mg/mL
S1238 Tamoxifen <1 mg/mL 74 mg/mL '''74 mg/mL
S5742 Deferoxamine mesylate -1 mg/mL 100 mg/mL -1 mg/mL
S7307 GSK2606414 <1 mg/mL 90 mg/mL ''19 mg/mL
S6889 Monomethyl Fumarate 20 mg/mL 26 mg/mL ''''26 mg/mL
S8597 LYN-1604 100 mg/mL 50 mg/mL '100 mg/mL
S2924 CHIR-99021 (CT99021) HCl <1 mg/mL 93 mg/mL '2 mg/mL
S2215 DAPT (GSI-IX) <1 mg/mL 86 mg/mL '50 mg/mL
S1241 Vincristine sulfate 60 mg/mL 100 mg/mL '''<1 mg/mL
S1274 BX-795 <1 mg/mL 100 mg/mL '<1 mg/mL
S1041 STF-62247 <1 mg/mL 53 mg/mL 3 mg/mL
S7153 10058-F4 <1 mg/mL 49 mg/mL '4 mg/mL
S1627 Nitazoxanide <1 mg/mL 62 mg/mL '<1 mg/mL
S1204 Melatonin <1 mg/mL 47 mg/mL '47 mg/mL
S5144 Neferine -1 mg/mL 100 mg/mL -1 mg/mL
S2271 Berberine chloride <1 mg/mL 40 mg/mL <1 mg/mL
S7980 VPS34-IN1 <1 mg/mL 85 mg/mL ''85 mg/mL
S4750 Sulfacetamide sodium salt hydrate 50 mg/mL 50 mg/mL 2 mg/mL

Autophagy製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1013

Bortezomib (PS-341)

Bortezomib (PS-341, LDP-341, MLM341) is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.

S3239

Emetine Dihydrochloride

Emetine Dihydrochloride, a principal alkaloid extracted from the root of ipecac clinically used as an emetic and antiprotozoal drug, reduces HIFs (hypoxia-inducible factors; HIF-1α and HIF-2α), PDK1, RhoA, Rho-kinases (ROCK1 and ROCK2) and BRD4. Emetine Dihydrochloride inhibits cellular autophagy and has anti-malarial, anti-viral, anti-bacterial and anti-amoebic effect.

S3233

Emetine hydrochloride

Emetine hydrochloride (NSC 33669), a principal alkaloid extracted from the root of ipecac clinically used as an emetic and antiprotozoal drug, reduces HIFs (hypoxia-inducible factors; HIF-1α and HIF-2α), PDK1, RhoA, Rho-kinases (ROCK1 and ROCK2) and BRD4. Emetine hydrochloride inhibits cellular autophagy and has anti-malarial, anti-viral, anti-bacterial and anti-amoebic effect.

S6847

ML-9 HCl

ML-9 HCl (ML-9 hydrochloride) is a selective and potent inhibitor of Akt kinase, myosin light chain kinase (MLCK) and stromal interaction molecule 1 (STIM1). ML-9 HCl is also a potent inhibitor of Ca2+-permeable channels. ML-9 HCl is a lysosomotropic agent targeting autophagy and cell death.

S6851

RA-190

RA190, a bis-benzylidine piperidon, is a potent, selective and oral effective inhibitor of proteasome ubiquitin receptor RPN13/ADRM1 with anticancer activity. RA190 triggers ER stress response, p53/p21 signaling axis and autophagy in multiple myeloma cells.

S8943

VLX600

VLX600 is a novel iron-chelating inhibitor of oxidative phosphorylation (OXPHOS), potentiates the effect of radiation in tumor spheroids in a synergistic manner. VLX600 shows enhanced cytotoxic activity under conditions of nutrient starvation. VLX600 induces autophagy and mitochondrial inhibition with antitumor activity.

S0709

Tubastatin A TFA

Tubastatin A TFA (Tubastatin A trifluoroacetate salt) is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold). Tubastatin A promotes autophagy and increases apoptosis.

S6716

NSC 185058

NSC185058 inhibits ATG4B, the lipidation of LC3B, and autophagy without affecting the MTOR or PtdIns3K pathways.

S1109

BI 2536

BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. BI-2536 inhibits Bromodomain 4 (BRD4) with Kd of 37 nM and potently suppresses c-Myc expression. BI-2536 induces apoptosis and attenuates autophagy. Phase 2.

S1105

LY294002

LY294002 (SF 1101, NSC 697286) is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family. LY294002 also inhibits CK2 with IC50 of 98 nM. LY294002 is a non-specific DNA-PKcs inhibitor and activates autophagy and apoptosis.

S1092

KU-55933 (ATM Kinase Inhibitor)

KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor with IC50/Ki of 12.9 nM/2.2 nM in cell-free assays, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR. KU‑55933 (ATM Kinase Inhibitor) inhibits the activation of autophagy‑initiating kinase ULK1 and results in a significant decrease of autophagy.

S1102

U0126-EtOH

U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity.

S1150

Paclitaxel

Paclitaxel (NSC 125973, PTX, Taxol, Onxal) is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.

S1460

SP600125

SP600125 (Nsc75890) is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc. SP600125 is also a broad‐spectrum inhibitor of serine/threonine kinases including Aurora kinase AFLT3 and TRKA with of IC50 of 60 nM, 90 nM and 70 nM. SP600125 inhibits autophagy and activates apoptosis.

S1490

Ponatinib (AP24534)

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively. Ponatinib (AP24534) inhibits autophagy.

S1113

GSK690693

GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. GSK690693 also potently inhibits AMPK and DAPK3 from the CAMK family with IC50 of 50 nM and 81 nM, respectively. GSK690693 affects Unc-51-like autophagy activating kinase 1 (ULK1) activity, robustly inhibits STING-dependent IRF3 activation. Phase 1.

S2758

Wortmannin

Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM in a cell-free assay, with little selectivity within the PI3K family. Wortmannin blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM in cell-free assays. Wortmannin also inhibits PLK1 activity.

S2704

LY2109761

LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM in a cell-free assay, respectively; shown to negatively affect the phosphorylation of Smad2. LY2109761 blocks autophagy and induces apoptosis.

S2767

3-Methyladenine (3-MA)

3-Methyladenine (3-MA, NSC 66389) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM in HeLa cells; blocks class I PI3K consistently, whereas suppression of class III PI3K is transient, and also blocks autophagosome formation. 3-Methyladenine (3-MA) is successfully used to suppress mitophagy. Solutions of 3-MA are best fresh-prepared by heating.

S2243

Degrasyn (WP1130)

Degrasyn (WP1130) is a selective deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor and also suppresses Bcr/Abl, also a JAK2 transducer (without affecting 20S proteasome) and activator of transcription (STAT). Degrasyn (WP1130) induces apoptosis and blocks autophagy.

S1786

Verteporfin

Verteporfin (CL 318952, Visudyne) is a small molecule that inhibits TEAD–YAP association and YAP-induced liver overgrowth. It is also a potent second-generation photosensitizing agent derived from porphyrin. Verteporfin is an autophagy inhibitor. Verteporfin inhibits cell proliferation and induces apoptosis.

S7046

Brefeldin A

Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis. It could also improve the HDR(homology-directed repair) efficiency and be an enhancer of CRISPR-mediated HDR. Brefeldin A is also an inhibitor of autophagy and mitophagy.

S8037

Necrostatin-1

Necrostatin-1 is a specific RIP1 (RIPK1) inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells. Necrostatin-1 also blocks IDO and suppresses autophagy and apoptosis.

S2775

Nocodazole

Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively. Nocodazole induces apoptosis.

S3042

Purmorphamine

Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM in HEK293T cell and also is an inducer of osteoblast differentiation with EC50 of 1 μM. Purmorphamine can reduce both basal and induced autophagy.

S1346

Heparin sodium

Heparin sodium, a sulfated polysaccharide belonging to the family of glycosaminoglycans, has numerous important biological activities associated with its interaction with diverse proteins. Heparin is used as an anticoagulant primarily through its interaction with AT III by enhancing AT-IIImediated inhibition of blood coagulation factors, including thrombin and factor Xa. Heparin prevents the induction of autophagy.

S4157

Chloroquine diphosphate

Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Chloroquine is also an inhibitor of toll-like receptors (TLRs).

S7033

GSK2656157

GSK2656157 is an ATP-competitive and highly selective inhibitor of PERK with IC50 of 0.9 nM in a cell-free assay, 500-fold greater against a panel of 300 kinases. GSK2656157 decreases apoptosis and inhibits excessive autophagy.

S1733

Methylprednisolone

Methylprednisolone (NSC-19987) is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.

S1413

Bafilomycin A1(Baf-A1)

Bafilomycin A1 is a vacuolar H+-ATPase inhibitor with IC50 of 0.44 nM. Bafilomycin A1 is found to inhibit autophagy while induces apoptosis.

S1835

Azithromycin

Azithromycin is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.

S2930

Pifithrin-μ

Pifithrin-μ (NSC 303580, PFTμ) is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.

S8808

DC661

DC661 is capable of deacidifying the lysosome and inhibiting autophagy significantly better than hydroxychloroquine (HCQ). DC661 induces apoptosis.

S7289

PFK15

PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.

S7885

SBI-0206965

SBI-0206965 is a highly selective autophagy kinase ULK1 inhibitor with IC50 of 108 nM, about 7-fold selectivity over ULK2. SBI-0206965 inhibits autophagy and enhances apoptosis in human glioblastoma and lung cancer cells.

S8576

EAD1

EAD1 is a potent autophagy inhibitor with an IC50 of 5.8 μM in the BxPC3 cells. It has antiproliferative activities in lung and pancreatic cancer cells.

S8274

STO-609

STO-609 is a specific inhibitor of the Ca2+/Calmodulin-dependent protein kinase kinase(CaM-KK) that inhibits the activities of recombinant CaM-KKα and CaM-KKβ isoforms, with Ki values of 80 and 15 ng/ml, respectively, and also inhibits their autophosphorylation activities. STO-609 inhibits AMPKK activity and inhibits autophagy.

S8764

IITZ-01

IITZ-01 is a potent autophagy inhibitor, enhancing autophagosome accumulation but inhibiting autophagosomal degradation by impairing lysosomal function.

S7888

Spautin-1

Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ∼0.6-0.7 μM. Spautin-1 enhances apoptosis.

S8317

3BDO

3BDO, a butyrolactone derivative, could target FKBP1A and activate the mTOR signaling pathway. It inhibits autophagy in HUVECs. 3BDO inhibits oxLDL-induced apoptosis.

S7811

MHY1485

MHY1485 is a potent, and cell-permeable mTOR activator, and also potently inhibits autophagy.

S8596

Autophinib

Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapamycin induced autophagy assay. The IC50 value for Vps34 is 19 nM in vitro.

S7423

KN-93 Phosphate

KN-93 Phosphate is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.37 μM, no remarkable inhibitory effects on APK, PKC, MLCK or Ca2+-PDE activities. KN-93 attenuates CaMKII-induced autophagy.

S8807

PFK158

PFK158 is a potent and selective inhibitor of PFKFB3. It has improved PK properties and causes ~80% growth inhibition in several mouse models of human-derived tumors.

S3758

Sinomenine hydrochloride

Sinomenine (SN, Cucoline, Kukoline, Sabianine A), extracted from the Chinese medicinal plant, sinomenium acutum, is a potent anti-inflammatory and neuroprotective agent.

S7948

MRT67307 HCl

MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. MRT67307 potently inhibits ULK1 and ULK2 and blocks autophagy.

S8369

Lys05

Lys05 is a new lysosomal autophagy inhibitor which potently accumulates within and deacidifies the lysosome of both cells and tumors, resulting in sustained inhibition of autophagy and tumor growth.

S7455

Resatorvid (TAK-242)

Resatorvid (TAK-242) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α, IL-6, and IL-1β in macrophages with IC50 values of 1-11 nM. Resatorvid inhibits autophagy.

S7660

Obeticholic Acid

Obeticholic Acid is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 99 nM. Obeticholic Acid inhibits autophagy. Phase 3.

S7146

DMH1

DMH1 is a selective BMP receptor inhibitor with IC50 of 107.9 nM for ALK2, exhibiting no inhibition on AMPK, ALK5, KDR (VEGFR-2) or PDGFR. DMH1 inhibits autophagy.

S4430

Hydroxychloroquine Sulfate

Hydroxychloroquine Sulfate (HCQ) is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR) 7/9.

S7949

MRT68921 HCl

MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.

S8744

PHY34

PHY34 is a late-stage autophagy inhibitor with nanomolar potency and significant antitumor efficacy as a single agent against HGSOC in vivo.

S5920

CA-5f

CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.

S8222

AS1842856

AS1842856 is a cell-permeable inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM. It could directly bind to the active Foxo1, but not the Ser256-phosphorylated form. AS1842856 suppresses autophagy.

S7682

SAR405

SAR405 is a low-molecular-mass kinase inhibitor of PIK3C3/Vps34 (KD 1.5 nM) showing high selectivity and not be active up to 10 μM on class I and class II PI3Ks as well as on mTOR. SAR405 prevents autophagy and synergizes with MTOR (mechanistic target of rapamycin) inhibition in tumor cells.

S7683

PIK-III

PIK-III (VPS34-IN2), which is a selective inhibitor of ​VPS34 enzymatic activity, inhibits autophagy and de novo lipidation of LC3 and leads to the stabilization of autophagy substrates.

S8793

ULK-101

ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively.

S8527

ROC-325

ROC-325 is an orally available novel inhibitor of lysosomal-mediated autophagy which diminishes AML cell viability with the IC50 range of 0.7-2.2 μM.

S9424

Liensinine diperchlorate

Liensinine, a major isoquinoline alkaloid, inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. It is a novel autophagy/mitophagy inhibitor.

S6471

Lucanthone

Lucanthone is a novel autophagic inhibitor and also an orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1.

S7751

VER155008

VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90. VER155008 inhibits autophagy and causes reduced levels of HSP90 client proteins.

S9150

Daurisoline

Daurisoline, a bis-benzylisoquinoline alkaloid isolated from the rhizomes of Menispermum dauricum, is a potent autophagy blockers with antiarrhythmic effects.

S7381

Pepstatin A

Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases.

S1078

MK-2206 2HCl

MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. MK-2206 2HCl induces autophagy and apoptosis in cancer cells. Phase 2.

S1060

Olaparib (AZD2281)

Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM in cell-free assays, 300-times less effective against tankyrase-1. Olaparib induces significant autophagy that is associated with mitophagy in cells with BRCA mutations.

S1267

Vemurafenib (PLX4032)

Vemurafenib (PLX4032, RG7204) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM in cell-free assay. 10-fold selective for B-RafV600E over wild-type B-Raf in enzymatic assays and the cellular selectivity can exceed 100-fold. Vemurafenib (PLX4032, RG7204) induces autophagy.

S1047

Vorinostat (SAHA)

Vorinostat (suberoylanilide hydroxamic acid, SAHA, MK0683) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.

S6797

QX77

QX77 is a novel activator of chaperone-mediated autophagy (CMA). QX77 induces the up-regulation of Rab11 expression and up-regulates LAMP2A expression.

S6650

EN6

EN6 is a novel covalent autophagy activator and targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase with an IC50 of 1.7 μM for recombinant human ATP6V1A protein.

S1002

ABT-737

ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. ABT-737 induces mitochondrial pathway apoptosis and mitophagy. Phase 2.