Obeticholic Acid

For research use only. Not for use in humans.

製品コードS7660 別名:INT-747, 6-ECDCA, 6-Ethylchenodeoxycholic acid

Obeticholic Acid化学構造

CAS No. 459789-99-2

Obeticholic Acid (INT-747, 6-ECDCA, 6-Ethylchenodeoxycholic acid) is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 99 nM. Obeticholic Acid inhibits autophagy. Phase 3.

サイズ 価格(税別)  
JPY 18100
JPY 59600
JPY 164100
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バルク問合せ

カスタマーフィードバック(3)

  • (c) Functional bile canaliculi or lack thereof in PHHs within MPTCs (12 d of drug treatment) as visualized by transport of fluorescent (green) dye into the canaliculi between PHHs. DMSO-treated MPCC control image is shown to the far right. (d) Neutral lipid (Nile red, green) staining of PHHs within MPTCs (12 d of drug treatment). DMSO-treated MPCC control image is shown to the far right. (e) NR1I2 (PXR) gene expression in drug-treated MPTCs relative to DMSOtreated MPTC controls (12 d of treatment). (f) ABCC2 (MRP2) gene expression in drug-treated MPTCs relative to DMSO-treated MPTC controls (12 d of treatment). (g) IL-6 levels in drug-treated MPTC supernatants (6 d of treatment). In all panels, statistical significance is displayed relative to DMSO-treated MPTCs. *p r 0.05, **p r 0.01, ***p r 0.001, and ****p r 0.0001. Scale bars on images represent 80 mm.

    Integr Biol (Camb), 2017, 9(8):662-677. Obeticholic Acid purchased from Selleck.

  • HuCCT1 cells were treated with OCA (1 μM) and control solvent in the presence and absence of IL-6 (20 ng/mL). EMT-related proteins were examined by western blotting. β-actin was used as a control.

    Cell Physiol Biochem, 2018, 48(1):158-172. Obeticholic Acid purchased from Selleck.

  • (D) Expression of hepatic FXR target genes, n = 3. Data are expressed as mean ± SD, ###P < 0.001 versus group 1, *P < 0.05, **P < 0.01, and ***P b 0.001 versus group 2, sP < 0.05, ssP < 0.01, and sssP < 0.001 versus group 3

    Toxicol Appl Pharmacol, 2017, 315:23-34. Obeticholic Acid purchased from Selleck.

質量管理及び製品安全説明書

FXR阻害剤の選択性比較

生物活性

製品説明 Obeticholic Acid (INT-747, 6-ECDCA, 6-Ethylchenodeoxycholic acid) is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 99 nM. Obeticholic Acid inhibits autophagy. Phase 3.
ターゲット
FXR [1]
99 nM(EC50)
体外試験

In HuH7 cells, Obeticholic Acid acts as a potent FXR agonist with EC50 of 85 nM. [1]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
insect cells MYHGeY5kfGmxbjDhd5NigQ>? NGLS[nAyKGi{ MWfB[49vcXO2IHHjeIl3cXS7IHH0JJJm[2:vYnnuZY51KGi3bXHuJGdUXC22YXfn[YQhTliUIHzp[4Fv\CCkaX7kbY5oKGSxbXHpckApOTl|IITvJFQ4OiC{ZYPp[JVmeyliZYjwdoV{e2WmIHnuJIJi[3Wub4\pdpV{KGmwZnXjeIVlKGmwc3XjeEBk\WyuczDhd5Nme3OnZDDhd{BqdmS3Y4Tpc44hd2ZiaX70[ZJi[3Srb36ge4l1cCCkaX;0bY4hdGGkZXzs[YQhW1KFLUGgZYZ1\XJiMTDodkBjgSCKVGLGJIF{e2G7LDDFR|UxKD1iMD6wNUDPxE1w NHqwWWY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUG0PFgxPid-MkmxOFg5ODZ:L3G+
HEK293T MYfGeY5kfGmxbjDhd5NigQ>? M4TRUlI1KGi{cx?= NIr2WoRC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJGZZWiCneIDy[ZN{\WRiaX6gTGVMOjl|VDDj[YxteyCjc4Pld5Nm\CCjczDCV2VRKHC{b33veIVzKGS{aY\lckBk\WyudXzhdkB1emGwc3PybZB1cW:wYXygZYN1cX[rdImgZYZ1\XJiMkSgbJJ{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3MDC9JFAvODR{IN88UU4> NGnnT4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUG0PFgxPid-MkmxOFg5ODZ:L3G+
COS1 MXjGeY5kfGmxbjDhd5NigQ>? MVjB[49vcXO2IHHjeIl3cXS7IHH0JGZZWiCneIDy[ZN{\WRiaX6gR29UOSClZXzsd{BjgSClZXzsMYJie2WmIHLpc4x2dWmwZYPj[Y5k\SCjc4PhfUwhTUN3MDC9JFAvODl7IN88UU4> NIf2cIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MECxOFg4OCd-MkCwNVQ5PzB:L3G+
HeLa M13X[mZ2dmO2aX;uJIF{e2G7 NH3qTIQzPCCqcoO= M17NcWFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6g[pVtdCCuZX7neIghTliUIHX4dJJme3OnZDDpckBJ\UyjIHPlcIx{KGOxdILhcpNn\WO2ZXSge4l1cCCyU1e1MYh2dWGwIGLYVkBi\nSncjCyOEBpenNiYomgSJVidC2JbH:gcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwJF0hOC5zNjFOwG0v M2LFZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUO0NlI4Lz5{NUmzOFIzPzxxYU6=
HeLa MWHGeY5kfGmxbjDhd5NigQ>? NX7D[I9iSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBHYFJiZYjwdoV{e2WmIHnuJIh2dWGwIFjlUIEh[2WubIOgZZN{\XO|ZXSgZZMhemWlZYD0c5Ih[WO2aY\heIlwdiCkeTDCV2VRKHC{b33veIVzNWS{aY\lckBncXKnZnz5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NEA:KDBwMU[g{txONg>? NFXDS|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK1OVA{QSd-MkWyOVUxOzl:L3G+
insect cells NY\ZWmJ3TnWwY4Tpc44h[XO|YYm= M3S1bVEhcHJ? M1;HUGFod26rc4SgZYN1cX[rdImgZZQhemWlb33ibY5idnRiaIXtZY4hT1OWLYTh[4dm\CCIWGKgUGJFKChzOUOgeI8hPDd{IILld4llfWW|KTDlfJBz\XO|ZXSgbY4h[mGldXzveolzfXNvaX7m[YN1\WRiaX7z[YN1KGOnbHzzJIF{e2W|c3XkJIF{KHKnY4L1bZRu\W62IH;mJIJqd3SrbonsZZRm\CCVUlOxJJBmeHSrZHWgcYVie3W{ZXSgZYZ1\XJiMTDodkBjgSCDbIDoZZNkemWnbjDhd5NigSxiRVO1NEA:KDBwMUig{txONg>? NYrzWlJmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmyOVk4PDJpPkK5NlU6PzR{PD;hQi=>
COS1 NVezOGF{TnWwY4Tpc44h[XO|YYm= MWW1JIhzew>? M1Hjc2Fod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gSnhTKGW6cILld5Nm\CCrbjDDU3MyKGOnbHzzJIFnfGW{IEWgbJJ{KGK7IFPSSU1lemm4ZX6gcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwJF0hOC5|NkGg{txONg>? MkjKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4OEW2NFMoRjF5Nki1OlA{RC:jPh?=
CHO NEPjTWdHfW6ldHnvckBie3OjeR?= NYDLb2ZjPSCqcoO= MYDB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIGTHVlUh\XiycnXzd4VlKGmwIFPIU{Bk\WyuczDh[pRmeiB3IHjyd{BjgSCFUlWt[JJqfmWwIHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3MDC9JFAvPzV3IN88UU4> NFjx[Xc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[4OVYxOyd-MUe2PFU3ODN:L3G+
HEK293 M{PaTmZ2dmO2aX;uJIF{e2G7 NV;0eZhpOSCqch?= MVPB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIGTHVlUh\XiycnXzd4VlKGmwIFjFT|I6OyClZXzsd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDpcpRz[WOnbHz1cIFzKGODTWCgcIV3\WxiYX\0[ZIhOSCqcjDifUBVWi2IUlXUJIF{e2G7LDDFR|UxKD1iMD64OEDPxE1w MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJ3OUe0Nkc,Ojl{NUm3OFI9N2F-
NCI-H716 NGjYV2dHfW6ldHnvckBie3OjeR?= NHywWmFC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHRIWjVicnXj[ZB1d3JiZYjwdoV{e2WmIHnuJG5EUS2KN{G2JINmdGy|IHHzd4V{e2WmIHHzJIlvfHKjY3XscJVt[XJiY1HNVEBt\X[nbDDifUBVWi2IUlXUJIF{e2G7LDDFR|UxKD1iMkCg{txONg>? MnX3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NUm1PFAoRjJzNEW5OVgxRC:jPh?=
HepG2 NXztZXhMTnWwY4Tpc44h[XO|YYm= MUOyNEB2VQ>? NULvOmJUUW6mdXP0bY9vKG:oIF\YVk1u\WSrYYTl[EBUUFBibWLORUBmgHC{ZYPzbY9vKGmwIHj1cYFvKEincFeyJINmdGy|IHH0JFIxKHWPIHL5JHJVNVCFUh?= M1mzblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEW5OVgxLz5{MUS1PVU5ODxxYU6=
HepG2 NFjqXHpHfW6ldHnvckBie3OjeR?= M{PNVFEhfU1? NIqwOVFKdmS3Y4Tpc44hd2ZiRmjSMY1m\GmjdHXkJHNJWCCvUl7BJIV5eHKnc4Ppc44hcW5iaIXtZY4hUGWyR{KgZ4VtdHNiYYSgNUB2VSCkeTDSWE1RS1J? MnfPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NUm1PFAoRjJzNEW5OVgxRC:jPh?=
HepG2 MmnnSpVv[3Srb36gZZN{[Xl? M2Ll[VIxKHWP MUXJcoR2[3Srb36gc4YhTliULX3l[IlifGWmIFLTSXAhdVKQQTDlfJBz\XO|aX;uJIlvKGi3bXHuJGhmeEd{IHPlcIx{KGG2IEKwJJVOKGK7IGLUMXBEWg>? M1vtdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEW5OVgxLz5{MUS1PVU5ODxxYU6=
HepG2 M1H2O2Z2dmO2aX;uJIF{e2G7 NX3hd3FSOjBidV2= M4jrUGlv\HWldHnvckBw\iCIWGKtcYVlcWG2ZXSgU5N1[mW2YTDtVm5CKGW6cILld5Nqd25iaX6gbJVu[W5iSHXwS|Ih[2WubIOgZZQhOjBidV2gZpkhWlRvUFPS M1vlVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEW5OVgxLz5{MUS1PVU5ODxxYU6=
HepG2 NVXrV|B3TnWwY4Tpc44h[XO|YYm= MWKxJJVO NVX3VlBLUW6mdXP0bY9vKG:oIF\YVk1u\WSrYYTl[EBld3ewLYLl[5Vt[XSrb36gc4YhS3myN1GxJI1TVkFiZYjwdoV{e2mxbjDpckBpfW2jbjDI[ZBIOiClZXzsd{BifCBzIIXNJIJ6KFKWLWDDVi=> MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTR3OUW4NEc,OjF2NUm1PFA9N2F-
HepG2 M2\sdWZ2dmO2aX;uJIF{e2G7 NELaUWIzOCC3TR?= NUDFVJdbUW6mdXP0bY9vKG:oIF\YVk1u\WSrYYTl[EBld3ewLYLl[5Vt[XSrb36gc4YhS3myN1GxJI1TVkFiZYjwdoV{e2mxbjDpckBpfW2jbjDI[ZBIOiClZXzsd{BifCB{MDD1UUBjgSCUVD3QR3I> M{fMflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEW5OVgxLz5{MUS1PVU5ODxxYU6=
HepG2 MY\GeY5kfGmxbjDhd5NigQ>? NFfzVoQzOCC3TR?= NV[4bYxxSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBHYFJiZYjwdoV{e2WmIHnuJGhmeEd{IHPlcIx{KGG|c3Xzd4VlKGG|IILlcoltdGFibIXjbYZmemG|ZTDhZ5Rqfmm2eTDheEAzOCC3TTDifUBtfWOrZnXyZZNmKGKjc3XkJJRz[W6|YXP0bZZifGmxbjDhd5NigQ>? MnHmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NUm1PFAoRjJzNEW5OVgxRC:jPh?=
HepG2 MoPLSpVv[3Srb36gZZN{[Xl? MUOxJJVO NGCzUoFKdmS3Y4Tpc44hd2ZiRmjSMY1m\GmjdHXkJGJUTVBibWLORUBmgHC{ZYPzbY9vKGmwIHj1cYFvKEincFeyJINmdGy|IHH0JFEhfU1iYomgVnQuWEOU M3fLWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEW5OVgxLz5{MUS1PVU5ODxxYU6=
HepG2 M3rOWWZ2dmO2aX;uJIF{e2G7 NVXnWIZDOSC3TR?= M2Dncmlv\HWldHnvckBw\iCIWGKtcYVlcWG2ZXSgU5N1[mW2YTDtVm5CKGW6cILld5Nqd25iaX6gbJVu[W5iSHXwS|Ih[2WubIOgZZQhOSC3TTDifUBTXC2SQ2K= M{TTVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEW5OVgxLz5{MUS1PVU5ODxxYU6=
HepG2 NX2xVHpuTnWwY4Tpc44h[XO|YYm= NEGzdYQyOCC3TR?= MkfvWJJidnOjY4TpeoF1cW:wIH;mJIh2dWGwIF\YVkB1emGwc3\lZ5Rm\CCrbjDoeY1idiCKZYDHNkBk\WyuczDheEAyOCC3TTDifUBj\XSjLXfhcIFkfG:|aXThd4UhemWyb4L0[ZIh\2WwZTDhd5NigQ>? M3jHeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{i3N|I2Lz5{NEO4O|MzPTxxYU6=
HepG2 NWfLNXhFTnWwY4Tpc44h[XO|YYm= MVixNEB2VQ>? M{\mVFE5KGi{cx?= M175UWFod26rc4SgZYN1cX[rdImgZZQhTliUIHnuJIh2dWGwIFjldGczKGOnbHzzJIF{e2W|c3XkJIF{KHWycnXneYxifGmxbjDv[kBQW1RvYXzwbIEhdVKQQTDlfJBz\XO|aX;uJIF1KDFyIIXNJIFnfGW{IEG4JIhzeyCkeTDSWE1RS1JiYX7hcJl{cXN? NW[yPI9QRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzPFc{OjVpPkK0N|g4OzJ3PD;hQi=>
GLUTag MU\GeY5kfGmxbjDhd5NigQ>? MVXB[49vcXO2IHHjeIl3cXS7IHH0JGdRNUKDUkGgbY4hdW:3c3WgS2xWXGGpIHPlcIx{KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIlvfHKjY3XscJVt[XJiY1HNVEBt\X[nbB?= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN6N{OyOUc,OjR|OEezNlU9N2F-
HepG2 NILCemNHfW6ldHnvckBie3OjeR?= NUHvZXo1OTBidV2= NF;aNGIyQCCqcoO= M2\Pc2Fod26rc4SgZYN1cX[rdImgZZQhTliUIHnuJIh2dWGwIFjldGczKGOnbHzzJIF{e2W|c3XkJIF{KHWycnXneYxifGmxbjDv[kBUUFBibWLORUBmgHC{ZYPzbY9vKGG2IEGwJJVOKGGodHXyJFE5KGi{czDifUBTXC2SQ2KgZY5idHm|aYO= MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN6N{OyOUc,OjR|OEezNlU9N2F-
HepG2 NIXyR5VHfW6ldHnvckBie3OjeR?= NUDFWFFMOTBidV2= NILTeJoyQCCqcoO= M4PsR2Fod26rc4SgZYN1cX[rdImgZZQhTliUIHnuJIh2dWGwIFjldGczKGOnbHzzJIF{e2W|c3XkJIF{KHWycnXneYxifGmxbjDv[kBDTVOSIH3SUmEh\XiycnXzd4lwdiCjdDCxNEB2VSCjZoTldkAyQCCqcoOgZpkhWlRvUFPSJIFv[Wy7c3nz MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN6N{OyOUc,OjR|OEezNlU9N2F-
GLUTag MUPGeY5kfGmxbjDhd5NigQ>? M3v4fGFod26rc4SgZYN1cX[rdImgZZQhT1BvQlHSNUBqdiCvb4Xz[UBIVFWWYXegZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hT0ySLUGgdoVt\WG|ZR?= NFHRcY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO4O|MzPSd-MkSzPFc{OjV:L3G+

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

アッセイ
Methods Test Index PMID
Western blot
XBP1s; 

PubMed: 29377207     


Huh7-Ntcp cells were treated with 6-ECDCA (0-10 μM) or DMSO vehicle for 4 hours. Representative western blot of XBP1s is shown with GAPDH used as a loading control.

p-IRE1α; 

PubMed: 29377207     


Huh7-Ntcp cells were treated with 2.5 μM 6-ECDCA or DMSO for 2 hours. Western blotting was performed for phosphorylated-IRE1α (p-IRE1α). Cellular p-IRE1α expression is increased in Huh7-Ntcp cells in response to FXR-agonist treatment.

29377207
体内試験 In rat cholestasis model, Obeticholic Acid promotes bile flow, and protects hepatocytes against acute necrosis caused by LCA. [1] Obeticholic Acid (p.o.) improves proteinuria, ameliorates renal structural changes, and modulates renal inflammation and oxidative stress in WD-fed DBA mice. [2] In thioacetamide (TAA)-intoxicated and bile-duct-ligated (BDL) rats, Obeticholic Acid (30 mg/kg p.o.) reactivates the FXR downstream signaling pathway and decreases portal pressure by lowering total IHVR without deleterious systemic hypotension. [3]

お薦めの試験操作(参考用のみ)

動物試験:

[1]

- 合併
  • 動物モデル: Rat cholestasis model
  • 投薬量: Saline
  • 投与方法: Infused at the right jugular vein using PE-50 polyethylene tubing
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 84 mg/mL (199.7 mM)
Water Insoluble
Ethanol ''84 mg/mL warmed ''84

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 420.63
化学式

C26H44O4

CAS No. 459789-99-2
Storage powder
in solvent
別名 INT-747, 6-ECDCA, 6-Ethylchenodeoxycholic acid
Smiles CCC1C2CC(CCC2(C3CCC4(C(C3C1O)CCC4C(C)CCC(=O)O)C)C)O

投与溶媒組成計算器(クリア溶液)

ステップ1:実験データを入力してください。(実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します)
投与量 mg/kg 動物平均体重 g 投与体積(動物毎) ul 動物数
ステップ2:投与溶媒の組成を入力してください。(ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください)
% DMSO % % Tween 80 % ddH2O
計算リセット

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (mg) = 濃度 (mM) x 体積 (mL) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02633956 Completed Drug: Obeticholic Acid|Drug: Atorvastatin|Drug: Placebo Nonalcoholic Steatohepatitis Intercept Pharmaceuticals December 4 2015 Phase 2
NCT02548351 Active not recruiting Drug: Obeticholic Acid|Drug: Placebo Non Alcoholic Steatohepatitis (NASH) Intercept Pharmaceuticals September 22 2015 Phase 3

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    What formulation can we use to dissolve Obeticholic Acid (Catalog No.S7660) for mice in vivo study?

  • 回答:

    You can use the vehicle of: 1% wt/vol methyl-cellulose as indicated in this paper, http://www.sciencedirect.com/science/article/pii/S0925443911000883 "daily oral gavage with 5 mg/kg/day INT-747 (6-ethyl-chenodeoxycholic acid, Obeticholic acid, Intercept Pharmaceuticals Inc, New York, NY) or vehicle (1% wt/vol methyl-cellulose) from 3 days prior to induction of colitis"

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Tags: Obeticholic Acidを買う | Obeticholic Acid ic50 | Obeticholic Acid供給者 | Obeticholic Acidを購入する | Obeticholic Acid費用 | Obeticholic Acid生産者 | オーダーObeticholic Acid | Obeticholic Acid化学構造 | Obeticholic Acid分子量 | Obeticholic Acid代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID