Erlotinib

For research use only. Not for use in humans.

製品コードS7786 別名:CP358774, NSC 718781, OSI-774

Erlotinib化学構造

CAS No. 183321-74-6

Erlotinib (CP358774, NSC 718781, OSI-774) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Erlotinib induces autophagy.

サイズ 価格(税別)  
JPY 18100
JPY 34700
最寄りの販売代理店を探す

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バルク問合せ

文献中Selleckの製品使用例(439)

製品安全説明書

EGFR阻害剤の選択性比較

生物活性

製品説明 Erlotinib (CP358774, NSC 718781, OSI-774) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Erlotinib induces autophagy.
ターゲット
EGFR [1]
(Cell-free assay)
2 nM
体外試験

Erlotinib HCl potently inhibits EGFR activation in intact cells including HNS human head and neck tumor cells (IC50 20nM), DiFi human colon cancer cells and MDA MB-468 human breast cancer cells. Erlotinib HCl (1 μM) induces apoptosis in DiFi human colon cancer cells. [1] Erlotinib inhibits growth of a panel of NSCLC cell lines including A549, H322, H3255, H358 H661, H1650, H1975, H1299, H596 with IC50 ranging from 29 nM to >20 μM. [2] Erlotinib HCl(2 μM) significantly inhibits growth of AsPC-1 and BxPC-3 pancreatic cells. [3] The effects of Erlotinib HCl in combination with gemcitabine are considered additive in KRAS-mutated pancreatic cancer cells. Ten micromolar of Erlotinib HCl inhibits EGFR phospho-rylation at the Y845 (Src-dependent phosphorylation) and Y1068 (auto-phosphorylation) sites. [4] Combination with Erlotinib HCl could down-modulate rapamycin-stimulated Akt activity and produces a synergistic effect on cell growth inhibition. [5]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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HepG2 NWfnSIVmSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NXXnellYPDhiaILz MnnnRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZYDHNkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD6xNkDPxE1w MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4Mk[2NEc,OjN7NkK2OlA9N2F-
A549 NHTNcJZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NILSPYw1QCCqcoO= MVfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwMUOg{txONg>? NGrUV3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2NlY3OCd-MkO5OlI3PjB:L3G+
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HepG2 MWrDfZRwfG:6aXPpeJkh[XO|YYm= MYm0PEBpenN? NV3v[FY5S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuNVIh|ryPLh?= NIH2VpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEG0OFg2PCd-MkSxOFQ5PTR:L3G+
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A431 NFLibYFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MmKzO|IhcHK| MYHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF2M{GgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IGPSRkBie3OjeTygTWM2OCB;IECuOVYh|ryPLh?= NWr2dpRuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1OlU6PjlpPkK0OVY2QTZ7PD;hQi=>
NCI-H1975 M2m5cGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MkKyO|IhcHK| NH3kOFRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIdm\mm2aX7pZk1z\XOrc4ThcpQhcHWvYX6gUmNKNUhzOUe1JINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTC3MlA3KM7:TT6= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV4NUm2PUc,OjR3NkW5Olk9N2F-
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HepG2 NIHt[FVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MmLJOFghcHK| NWH4bYVLSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNE4yOiEQvF2u MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZyN{m5PEc,OjR4MEe5PVg9N2F-
A549 MXPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NUf4dYxCPDhiaILz NIjSNWlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuNVMh|ryPLh?= M33WclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkC3PVk5Lz5{NE[wO|k6QDxxYU6=
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HepG2 MkL2RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MnzmOFghcHK| NHvjS|FCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlEzKM7:TT6= MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ|MESxNkc,OjR4M{C0NVI9N2F-
A549 MX7BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MVS0PEBpenN? NXfENXl6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlE{KM7:TT6= NVv6V5dGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2N|A1OTJpPkK0OlMxPDF{PD;hQi=>
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MDA-MB-231 MmfNRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M2DiZlczKGi{cx?= Mk\lRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFMxNjF{IN88UU4> M2P6R|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUKzN|g{Lz5{OEmyN|M5OzxxYU6=
MDA-MB-231 MlXNRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NHyybWc1QCCqcoO= MV7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0zOzFiY3XscJMhcW6ldXLheIVlKG[xcjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|MvPDZizszNMi=> NILsN|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEmyN|M5Oyd-Mki5NlM{QDN:L3G+
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A549 MkG2R5l1d3SxeHnjbZR6KGG|c3H5 NVPhUWg6OjRiaILz NVrZ[ZlTS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC55MzFOwG0v MkH2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlyMki1N|QoRjJ7MEK4OVM1RC:jPh?=
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HT-29 MWLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MW[0PEBpenN? M3XXVGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIh2dWGwIFjUMVI6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pLXLhd4VlKG[udX;y[ZNk\W6lZTDhd5NigSxiSVO1NEA:KDBwMEKg{txONg>? NHjlNJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSwO|k2Pid-Mkm0NFc6PTZ:L3G+
MIAPaCa2 MkXjRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? Mk\YOFghcHK| NETNNXFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBpfW2jbjDNTWFR[UOjMjDj[YxteyCjZoTldkA1QCCqcoOgZpkheHKxcHnkbZVuKGmxZHnk[UB{fGGrbnnu[{1j[XOnZDDmcJVwemW|Y3XuZ4Uh[XO|YYmsJGlEPTBiPTCwMlA{KM7:TT6= MlHHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2MEe5OVYoRjJ7NEC3PVU3RC:jPh?=
MCF7 M{XXfGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MojBOFghcHK| M{fCUGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiNEigbJJ{KGK7IIDyc5Bq\Gm3bTDpc4Rq\GVic4ThbY5qdmdvYnHz[YQh\my3b4Lld4NmdmOnIHHzd4F6NCCLQ{WwJF0hOC5yMzFOwG0v NVu1b4tQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0NFc6PTZpPkK5OFA4QTV4PD;hQi=>
PC3 NXnCZmhESW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MUS0PEBpenN? M1LzNGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIh2dWGwIGDDN{Bk\WyuczDh[pRmeiB2ODDodpMh[nlicILvdIllcXWvIHnv[Ill\SC|dHHpcolv\y2kYYPl[EBndHWxcnXzZ4Vv[2ViYYPzZZktKEmFNUCgQUAxNjB|IN88UU4> NWHhWXVuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0NFc6PTZpPkK5OFA4QTV4PD;hQi=>
A549 M4TlOmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MXm0PEBpenN? NXKxc4FbSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjC0PEBpenNiYomgdJJweGmmaYXtJIlw\GmmZTDzeIFqdmmwZz3iZZNm\CCobIXvdoV{[2WwY3WgZZN{[XluIFnDOVAhRSByLkC0JO69VS5? NHnVfm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSwO|k2Pid-Mkm0NFc6PTZ:L3G+
Sf9 MnXlSpVv[3Srb36gZZN{[Xl? MlHHNVAhdWmwcx?= NFXTdVRKdmirYnn0bY9vKG:oIFjpd|YufGGpZ3XkJGVITlJiKIXub45wf25ib4Lp[4lvMSCleYTvdIxie22rYzDkc41icW5iZYjwdoV{e2WmIHnuJIJi[3Wub4\pdpV{KGmwZnXjeIVlKFOoOTDpcpNm[3RiY3XscJMh[W[2ZYKgNVAhdWmwczDmc4xtd3enZDDifUBi\GSrdHnvckBw\iCDVGCtUYdEdDJiYX7kJI1m[XO3cnXkJIFnfGW{IEGgbJIh[nlidHnt[U1z\XOxbI\l[EBndHWxcn;t[ZRzcWNiYX7hcJl{cXNuIFnDOVAhRSByLkC4JO69VS5? MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTRyN{m1Okc,Ojl2MEe5OVY9N2F-
Sf9 Mn\mSpVv[3Srb36gZZN{[Xl? MYLJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IH\1cIwudGWwZ4ToJGdUXC22YXfn[YQhcHWvYX6gRk1TSUZiVk[wNGUhdXW2YX70JEg1OTdidH:gO|Y3KHKnc3nkeYV{MSCneIDy[ZN{\WRiaX6gRoFkfWyxdnnyeZMhcW6oZXP0[YQhW2Z7IHPlcIx{KHW|aX7nJG4ufGW{bXnuZYwhUGm|LYTh[4dm\CCqdX3hckBOTUtzIHHzJJN2[nO2cnH0[UBjgSCQdT3wZYdmKGenbD3iZZNm\CCyaH;zdIhweiC|Y4Ll[Y4h[W6jbInzbZMtKEmFNUCgQUAxNjB4IN88UU4> NGPxfWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUW0PVg1OSd-Mkm1OFk5PDF:L3G+
Sf9 MkL5SpVv[3Srb36gZZN{[Xl? Mn;UTY5pcWKrdHnvckBw\iCKaYOtOkB1[WepZXSgdoVkd22kaX7hcpQhTUeIUjDjfZRweGyjc33pZ{Bld22jaX6gLFY1PSC2bzCxNVg3KHKnc3nkeYV{MSBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDCZYN2dG:4aYL1d{Bqdm[nY4Tl[EBU\jliY3XscJMh[nliZHnzd49kcWG2aX;uMYVvcGGwY3XkJIxidnSqYX7p[IUh\my3b4Lld4NmdmOnIHntcZVvd2G|c3H5M5RqdWVvcnXzc4x3\WRiZnz1c5JwdWW2cnnjJIFv[Wy7c3nzMEBKSzVyIE2gNE4xQCEQvF2u MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV2OUi0NUc,Ojl3NEm4OFE9N2F-
A549 MUPBcpRq[2GwY3XyJIF{e2G7 Mm\YPVYhcHK| NX\HRYpESW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDl4IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzNz6zNkDPxE1w MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV2OUi0NUc,Ojl3NEm4OFE9N2F-
MCF7 NFn0cXVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NILMdI41QCCqcoO= M2[4XmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkCg{txONg>? NUTpNWViRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwOFc1OTBpPkOwNFQ4PDFyPD;hQi=>
HepG2 MYHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MojMOFghcHK| NYLpN5N7SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlUh|ryPLh?= MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB2N{SxNEc,OzByNEe0NVA9N2F-
Sf9 NEjSSldHfW6ldHnvckBie3OjeR?= MV[1JI1qdnN? NH7VXY9KdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIFfTWE11[WepZXSgTGVTOiBqNke2MYVv\CliZYjwdoV{e2WmIHnuJIJi[3Wub4\pdpV{KGmwZnXjeIVlKFOoOTDpcpNm[3RiY3XscJMheHKnaX7jeYJifGWmIH\vdkA2KG2rboOg[o9tdG:5ZXSgZpkhSVSSIHHk[Il1cW:wIHHu[EBu\WG|dYLl[EBi\nSncjCzNEBucW6|IHL5JGhVWkZiYYPzZZktKEmFNUCgQUAxNjB7MTFOwG0v M2q3[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEm2OVgxLz5|MEC5OlU5ODxxYU6=
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A431 M4\ZVWZ2dmO2aX;uJIF{e2G7 M2T5RVYxKG2rboO= MUTJcohq[mm2aX;uJI9nKEWJRj3pcoR2[2WmIFXHSnIh[WO2aY\heIlwdiCrbjDoeY1idiCDNEOxJINmdGy|IIDy[ZRz\WG2ZXSg[o9zKDZyIH3pcpMh\m:ubH;3[YQh[nliRVfGJIFl\Gm2aX;uJIFv\CCvZXHzeZJm\CCjZoTldkAyOCCvaX7zJIJ6KEWOSWPBMEBKSzVyIE2gNE4xODF{IN88UU4> Mo\6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByOUi4OlkoRjNyMEm4PFY6RC:jPh?=
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HEK293 Flp-In M3ziW2Z2dmO2aX;uJIF{e2G7 M3PDdWlvcGmkaYTpc44hd2ZiaIXtZY4hdGm4ZYKgU2FVWDGEMTDlfJBz\XO|ZXSgbY4hUEWNMkmzJGZteC2LbjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hTTF5LXLleIFIKHWydHHr[UBjgSC|Y3nueIltdGG2aX;uJINwfW62aX7nMEBMcSB;IEKxJO69VS5? NEjx[Gs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW0NVA3QCd-MkK1OFExPjh:L3G+
HEK293 Flp-In NFPpTpBHfW6ldHnvckBie3OjeR?= M3;5NVUhdWmwcx?= M3;Rc2lvcGmkaYTpc44hd2ZiaIXtZY4hdGm4ZYKgU2FVWDGEMzDlfJBz\XO|ZXSgbY4hUEWNMkmzJGZteC2LbjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hYzOKXVWxO{1j\XSjRzD1dJRic2ViaX7jeYJifGWmIH\vdkA2KG2rboOgZpkhe2OrboTpcIxifGmxbjDjc5VvfGmwZzygT4khRSB2MTFOwG0v M1LFclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NUSxNFY5Lz5{MkW0NVA3QDxxYU6=
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