Erlotinib (OSI-774)

For research use only. Not for use in humans.

製品コードS7786 別名:CP358774, NSC 718781, Tarceva

Erlotinib (OSI-774)化学構造

CAS No. 183321-74-6

Erlotinib (OSI-774, CP358774, NSC 718781, Tarceva) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Erlotinib induces autophagy.

サイズ 価格(税別)  
JPY 18100
JPY 34700
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バルク問合せ

文献中Selleckの製品使用例(486)

製品安全説明書

EGFR阻害剤の選択性比較

生物活性

製品説明 Erlotinib (OSI-774, CP358774, NSC 718781, Tarceva) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Erlotinib induces autophagy.
ターゲット
EGFR [1]
(Cell-free assay)
2 nM
体外試験

Erlotinib HCl potently inhibits EGFR activation in intact cells including HNS human head and neck tumor cells (IC50 20nM), DiFi human colon cancer cells and MDA MB-468 human breast cancer cells. Erlotinib HCl (1 μM) induces apoptosis in DiFi human colon cancer cells. [1] Erlotinib inhibits growth of a panel of NSCLC cell lines including A549, H322, H3255, H358 H661, H1650, H1975, H1299, H596 with IC50 ranging from 29 nM to >20 μM. [2] Erlotinib HCl(2 μM) significantly inhibits growth of AsPC-1 and BxPC-3 pancreatic cells. [3] The effects of Erlotinib HCl in combination with gemcitabine are considered additive in KRAS-mutated pancreatic cancer cells. Ten micromolar of Erlotinib HCl inhibits EGFR phospho-rylation at the Y845 (Src-dependent phosphorylation) and Y1068 (auto-phosphorylation) sites. [4] Combination with Erlotinib HCl could down-modulate rapamycin-stimulated Akt activity and produces a synergistic effect on cell growth inhibition. [5]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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NCI-H1975 MVTGeY5kfGmxbjDhd5NigQ>? NFnhN5YzKGi{cx?= NVK1XYNWUW6qaXLpeIlwdiCxZjDFS2ZTKEx6NUjSM3Q6PzCPIHTveYJt\SCvdYThcpQheGixc4Doc5J6dGG2aX;uJIlvKGi3bXHuJG5EUS2KMUm3OUBk\WyuczDh[pRmeiB{IHjyd{BjgSCobIXvdoV{[2WwY3WgZZN{[XluIFnDOVAhRSB5Lk[g{txONg>? NEHISHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{mzNFk6PCd-MkO5N|A6QTR:L3G+
Sf9 M1[wWGZ2dmO2aX;uJIF{e2G7 NFj5VIgyOCCvaX7z NH3aNlRKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JGVITlJia3nuZZNmKGO7dH;wcIF{dWmlIHTvcYFqdiBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDiZYN2dG:4aYL1d{BmgHC{ZYPzbY9vKH[nY4Tvdk1qdm[nY4Tl[EBqdnOnY4Sgd4Y6KGOnbHzzJIF{e2W|c3XkJIF{KGyndnXsJI9nKGG3dH;wbI9{eGixconsZZRqd25iYX\0[ZIhOTBibXnud{BjgSCGRVzGTWEwfGmvZT3y[ZNwdH[nZDDmcJVwem:vZYTyfUwhUUN3MDC9JFAvODNizszNMi=> NHXRTlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2NlY3OCd-MkO5OlI3PjB:L3G+
HepG2 M3nY[WFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MWi0PEBpenN? NEKyN3RCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlEzKM7:TT6= NHm4bGk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2NlY3OCd-MkO5OlI3PjB:L3G+
A549 MXLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M2\0W|Q5KGi{cx?= NHrie3ZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuNVMh|ryPLh?= MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4Mk[2NEc,OjN7NkK2OlA9N2F-
Sf9 MYfGeY5kfGmxbjDhd5NigQ>? NXfqN4ZQOTBibXnudy=> MoPzTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDFS2ZTKGO7dH;wcIF{dWmlIHTvcYFqdiBqNkS1JJRwKDFzOE[pJEh2dmuwb4fuJI9zcWerbjmgZZV1d3Cqb4PwbI9zgWyjdHnvckBmgHC{ZYPz[YQhcW5iYnHjeYxwfmm{dYOgbY5n\WO2ZXSgbY5{\WO2IGPmPUBk\WyuczDwdoVqdmO3YnH0[YQh\m:{IEGwJI1qdnNiZn;scI94\WRiYomgRXRRNU2pQ3yyJIFl\Gm2aX;uJI1m[XO3cnXkJIFnfGW{IEGgbJIh[nliZnz1c5JwdWW2cnnjJIFv[Wy7c3nzMEBKSzVyIE2gNE4xOzJizszNMi=> MnG1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzNES4OVQoRjJ2MUS0PFU1RC:jPh?=
HepG2 NWTqfJR[S3m2b4TvfIlkcXS7IHHzd4F6 MoT4OFghcHK| M4PDcGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkGyJO69VS5? Mn3zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzNES4OVQoRjJ2MUS0PFU1RC:jPh?=
A549 NVvIToIzS3m2b4TvfIlkcXS7IHHzd4F6 M{LjO|Q5KGi{cx?= NESye5hEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkGzJO69VS5? M{XD[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUS0PFU1Lz5{NEG0OFg2PDxxYU6=
A431 M2nscmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MlnhO|IhcHK| M37uNGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUSzNUBk\WyuczDh[pRmeiB5MjDodpMh[nliU2LCJIF{e2G7LDDJR|UxKD1iMD60NFkh|ryPLh?= M1;i[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUizO|QzLz5{NEG4N|c1OjxxYU6=
NCI-H1975 MlfzRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M1nndlczKGi{cx?= M2nWXWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWgyQTd3IHPlcIx{KGW6cILld5NqdmdiRVfGVkBVPzlyTTDteZRidnRiYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigSxiSVO1NEA:KDZwOTFOwG0v MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF6M{e0Nkc,OjRzOEO3OFI9N2F-
KB NGC5N|VHfW6ldHnvckBie3OjeR?= M1\IclEhcHJ? MlL0TY5pcWKrdHnvckBw\iCHR1[td5RqdXWuYYTl[EBifXSxcHjvd5Bpd3K7bHH0bY9vKG:oIFXHSnIhcW5iaIXtZY4hU0JiY3XscJMhcW6ldXLheIVlKG[xcjCxJIhzKHC{aX;yJJRwKEWJRjDjbIFtdGWwZ3WgcYVie3W{ZXSgZYZ1\XJiNjDtbY5{KGK7IFXMTXNCNCCLQ{WwJF0hOC5yMUmg{txONg>? Mn7sQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2MUGxNlMoRjJ2NEGxNVI{RC:jPh?=
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Calu3 NVfOR2dnS3m2b4TvfIlkcXS7IHHzd4F6 M4rlXFczKGi{cx?= NX[0c5MzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS2GudUOgZ4VtdHNiZYjwdoV{e2mwZzDISXIzKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjl|IN88UU4> NWXiVmplRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0NVEyOjNpPkK0OFEyOTJ|PD;hQi=>
NCI-H1975 NUO1WIFpS3m2b4TvfIlkcXS7IHHzd4F6 NHrUbng4OiCqcoO= NUDW[Xk6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVkOLLVixPVc2KGOnbHzzJIV5eHKnc4PpcochTUeIUjDMPFU5Wi:WN{mwUUBufXSjboSgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEWuOVEh|ryPLh?= MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDRzMUGyN{c,OjR2MUGxNlM9N2F-
A431 NWi3bpdZSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NWrt[VJoPzJiaILz NWj5PFRkSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOFMyKGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBUWkJiYYPzZZktKEmFNUCgQUAxNjV4IN88UU4> M2fjO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NU[1PVY6Lz5{NEW2OVk3QTxxYU6=
NCI-H1975 NHXhXW1CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MnHLO|IhcHK| M3;QPGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4Sg[4VncXSrbnniMZJme2m|dHHueEBpfW2jbjDOR2kuUDF7N{WgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IGPSRkBie3OjeTygTWM2OCB;IEeuNFYh|ryPLh?= M1XN[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NU[1PVY6Lz5{NEW2OVk3QTxxYU6=
Sf9 NGHpZmFHfW6ldHnvckBie3OjeR?= NGXCcXEyKGi{ MkjkTY5pcWKrdHnvckBw\iCjdYTvdIhwe3Cqb4L5cIF1cW:wIH;mJJJm[2:vYnnuZY51KEWJRmKgZ5l1d3CuYYPtbYMh\G:vYXnuJEg3PDVidH:gNVE5PiliKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJIFnfGW{IEGgbJIh[nliRFXMSmlCN3SrbXWtdoV{d2y4ZXSg[ox2d3KxbXX0dolkKGGwYXz5d4l{NCCLQ{WwJF0hOC5yM{Kg{txONg>? NIrL[3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[wO|k6QCd-MkS2NFc6QTh:L3G+
HepG2 NW\sWpB6SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NHPBXII1QCCqcoO= NWn1O|VmSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNE4yOiEQvF2u NIXpR3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[wO|k6QCd-MkS2NFc6QTh:L3G+
A549 Mne1RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MYG0PEBpenN? MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwMUOg{txONg>? NX\M[VZQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2NFc6QThpPkK0OlA4QTl6PD;hQi=>
Sf9 Mnq1SpVv[3Srb36gZZN{[Xl? MUKxJIhz M3;veGlvcGmkaYTpc44hd2ZiYYX0c5Bpd3OyaH;yfYxifGmxbjDv[kBGT0[UIHP5eI9xdGG|bXnjJIRwdWGrbjCoZY1qdm9iYXPp[JMhPjR3IITvJFEyQDZrIDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bi\nSncjCxJIhzKGK7IITpcYUuemW|b3z2[YQh\my3b4LvcYV1enluIFnDOVAhRSByLkCzNkDPxE1w MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ|MESxNkc,OjR4M{C0NVI9N2F-
HepG2 MmnZRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MnrJOFghcHK| MmnURY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZYDHNkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD6xNkDPxE1w MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ|MESxNkc,OjR4M{C0NVI9N2F-
A549 NIO4[4pCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M3S4VlQ5KGi{cx?= MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwMUOg{txONg>? MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ|MESxNkc,OjR4M{C0NVI9N2F-
Sf9 NUPiRmxxTnWwY4Tpc44h[XO|YYm= M1THc|EhcHJ? MlzsTY5pcWKrdHnvckBw\iCjdYTvdIhwe3Cqb4L5cIF1cW:wIH;mJIh2dWGwIFjFVlIh[3m2b4DsZZNucWNiZH;tZYlvKCijbXnuc{Bi[2mmczC2O|YhfG9iMUK0OUkhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5iU3[5JINmdGy|IHHmeIVzKDFiaIKgZpkhfGmvZT3y[ZNwdH[nZDDmcJVwem:vZYTyfUwhUUN3MDC9JFAvOTZizszNMi=> MmnyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4M{C0NVIoRjJ2NkOwOFEzRC:jPh?=
A431 NHf6e|lHfW6ldHnvckBie3OjeR?= M4XNNmlvcGmkaYTpc44hd2ZiRVfGVkBqdiCqdX3hckBCPDNzIHPlcIx{KGK7IIDoc5NxcG:2eYLvd4lv\SCHTFnTRUBie3OjeTygTWM2OCB;IECuNFAyOiEQvF2u M1fpS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEmwOlUzLz5{NEi5NFY2OjxxYU6=
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U251 NVnKSpRXTnWwY4Tpc44h[XO|YYm= NHXwc3lKdmirYnn0bY9vKG:oIG\FS2ZTOiCrbjDoeY1idiCXMkWxJINmdGy|IHL5JJBpd3OyaH;0fZJwe2mwZTDFUGlUSSCjc4PhfUwhUUN3MDC9JFAvOTJ2NzFOwG0v M1jWW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEmwOlUzLz5{NEi5NFY2OjxxYU6=
MDA-MB-468 NUL4flNiS3m2b4TvfIlkcXS7IHHzd4F6 NHHhWnlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckB1emmybHWgcoVo[XSrdnWgUWRCNU2ELUS2PEBk\WyuczygTWM2OCB;IECuNlM2OiEQvF2u MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh7ME[1Nkc,OjR6OUC2OVI9N2F-
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MDA-MB-435 M2rrU2N6fG:2b4jpZ4l1gSCjc4PhfS=> M3W1NmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj20N|Uh[2WubIOsJGlEPTBiPTCwMlYzOjFizszNMi=> NY\GN4FsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4PVA3PTJpPkK0PFkxPjV{PD;hQi=>
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HeLa M{HYOmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M2TufFEzKGi{cx?= NUfkV4RzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IEGyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlIh|ryPLh?= M4Oxb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NkWyOFgzLz5{Nk[1NlQ5OjxxYU6=
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A549 NUn4T|dzTnWwY4Tpc44h[XO|YYm= M4XzWGlvcGmkaYTpc44hd2ZiRVfGMZN1cW23bHH0[YQhf2muZDD0fZBmKEWJRmKgZZV1d3Cqb4PwbI9zgWyjdHnvckBmgHC{ZYPz[YQhcW5iaIXtZY4hSTV2OTDj[YxteyCkeTDzZY5lf2mlaDDFUGlUSSxiSVO1NEA:KDBwMEGxJO69VS5? NIjCUpQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nke1OlIzOid-Mk[3OVYzOjJ:L3G+
NCI-H1975 MVLGeY5kfGmxbjDhd5NigQ>? MYqyJIhzew>? MVjJcohq[mm2aX;uJI9nKEWJRmKgUFg2QFJxVEe5NG0h\G:3YnzlJI12fGGwdDDheZRweGixc4Doc5J6dGG2aX;uJIlvKGi3bXHuJG5EUS2KMUm3OUBk\WyuczDh[pRmeiB{IHjyd{BjgSC|YX7ke4lkcCCHTFnTRUwhUUN3MDC9JFkh|ryPLh?= M4\hWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4N{W2NlIzLz5{Nke1OlIzOjxxYU6=
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A549 MlrsRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MmXhOFghcHK| MmXoRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHzd4V{e2WmIHHzJJZq[WKuZTDj[YxteyCjZoTldkA1QCCqcoOgZpkhS0ONODDhd5NigSxiSVO1NEA:KDZwMk[g{txONg>? M4q3b|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OEe5N|E1Lz5{Nki3PVMyPDxxYU6=
NCI-H358 Mny4RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NXTOfZJkPDhiaILz NXuzNZdwSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDN3ODDj[YxteyCjc4Pld5Nm\CCjczD2bYFjdGViY3XscJMh[W[2ZYKgOFghcHK|IHL5JGNEUzhiYYPzZZktKEmFNUCgQUA3Njh3IN88UU4> NYHxcY5yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[4O|k{OTRpPkK2PFc6OzF2PD;hQi=>
HepG2 NUixRXBxSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M{fyUlQ5KGi{cx?= NWjTco1xSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOU45KM7:TT6= M4fJUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OEm2O|A5Lz5{Nki5OlcxQDxxYU6=
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NCI-H358 MVfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NYjUVnhiPDhiaILz MXjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE6FST3IN|U5KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkh[2OtODDhd5NigSxiSVO1NEA:KDNwOUGg{txONg>? MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzJ|NEi4O{c,Ojd{M{S4PFc9N2F-
A549 M2\jVWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MlXqOFghcHK| MX7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDjZ4s5KGG|c3H5MEBKSzVyIE2gO{4{PSEQvF2u Mn7BQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd{M{S4PFcoRjJ5MkO0PFg4RC:jPh?=
BA/F3 NIrkRmVHfW6ldHnvckBie3OjeR?= NH\jPJA1QCCqcoO= NVrzUoV3UW6qaXLpeIlwdiCxZjDFS2ZTKEx6NUjSJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBud3W|ZTDCRU9HOyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KFiWVDDhd5NigSxiSVO1NEA:KDBwMEi3JO69VS5? NV7lSJI5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkeyN|U5PDFpPkK3NlM2QDRzPD;hQi=>
A431 M1vp[2Z2dmO2aX;uJIF{e2G7 MWO2NEBucW6| MnvBTY5pcWKrdHnvckBw\iCHR1\SJIlvKGi3bXHuJGE1OzFiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJGVITiCrbnT1Z4VlKHCqb4PwbI9zgWyjdHnvckBxemWrbnP1ZoF1\WRiZn;yJFYxKG2rboOg[o9tdG:5ZXSgZpkhTUeIIHHk[Il1cW:wIH3lZZN2emWmIHHmeIVzKDFyIH3pcpMh[nliRVzJV2EhdWW2aH;kMEBKSzVyIE2gNE4xODF{IN88UU4> M3iySlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OEm0OVg6Lz5{N{i5OFU5QTxxYU6=
HEK293 MlH0SpVv[3Srb36gZZN{[Xl? MVGyJI1qdnN? M1Tvd2lvcGmkaYTpc44hd2ZiaIXtZY4hV0OWMTDlfJBz\XO|ZXSgbY4hUEWNMkmzJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKHWydHHr[UBw\iCDU2CrJIFnfGW{IEKgcYlveyCkeTDmcJVwemW|Y3XuZ4Uh[XO|YYmsJGlEPTBiPTCxOk4zKM7:TT6= Mnf1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{M{C5PFUoRjJ6MkOwPVg2RC:jPh?=
H3255 NIjwVXhHfW6ldHnvckBie3OjeR?= MoPoNkBpenN? M3vaVWlvcGmkaYTpc44hd2ZiRVfGVkBNQDV6UjDteZRidnRicHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKEh|MkW1JINmdGy|IIDy[Ylv[3WkYYTl[EBnd3JiMjDodpMh\m:ubH;3[YQh[nliRVfGJJN1cW23bHH0bY9vKG[xcjCxNEBucW6|IHL5JJNidmS5aXPoJGVNUVODLDDJR|UxKD1iMD6wNUDPxE1w NXPNc4lXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyPFc4OzBpPkK4Nlg4PzNyPD;hQi=>
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H1975 Mn\MSpVv[3Srb36gZZN{[Xl? NEPudlEzKGi{cx?= NGC0ZYNKdmirYnn0bY9vKG:oIFXHSnIhXDd7MF2vUFg2QFJiZH;1ZoxmKG23dHHueEBxcG:|cHjvdplt[XSrb36gbY4hcHWvYX6gTFE6PzViY3XscJMheHKnaX7jeYJifGWmIH\vdkAzKGi{czDmc4xtd3enZDDifUBGT0Zic4TpcZVt[XSrb36g[o9zKDFyIH3pcpMh[nlic3Hu[Jdq[2hiRVzJV2EtKEmFNUCgQUA6NjByMzFOwG0v M3[yU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6Mki3O|MxLz5{OEK4O|c{ODxxYU6=
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Sf9 NHrjTG5HfW6ldHnvckBie3OjeR?= NW\4UpFqOTBibXnudy=> M{DRTmlvcGmkaYTpc44hd2ZiSHnzOk11[WepZXSgdoVkd22kaX7hcpQhTUeIUjDjfZRweGyjc33pZ{Bld22jaX6gLJVvc26xd36gc5Jq\2mwKTCoOlQ2KHSxIEGxPFYhemW|aXT1[ZMqKGW6cILld5Nm\CCrbjDiZYN2dG:4aYL1d{Bqdm[nY4Tl[EBU\i17IHPlcIx{KHC{ZXnuZ5Vj[XSnZDDmc5IhOTBibXnud{Bnd2yub4fl[EBjgSCDVGCgZYRlcXSrb36gcYVie3W{ZXSgZYZ1\XJiMTDodkBjgSCGRVzGTWEwXGmvZT3S[ZNwdH[nZDDmcJVwem:vZYTyfUwhUUN3MDC9JFAvODZizszNMi=> NG\DeW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OESzNVM2Oyd-Mki0N|E{PTN:L3G+
HepG2 MlnrR5l1d3SxeHnjbZR6KGG|c3H5 MojaNlQhcHK| NYDDXXBjS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiMkSgbJJ{KGK7IIPw[YN1em:yaH;0c41mfHK7LDDJR|UxKD1iMkWg{txONg>? NWT2OZRzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0PFcyOjdpPkK4OFg4OTJ5PD;hQi=>
A549 NELJfnJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MmXnO|IhcHK| NX\2SXNTSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyNU4{KM7:TT6= MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDh6NkWwPUc,Ojh6OE[1NFk9N2F-
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