Chloroquine diphosphate

For research use only. Not for use in humans.

製品コードS4157

Chloroquine diphosphate化学構造

CAS No. 50-63-5

Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Chloroquine is also an inhibitor of toll-like receptors (TLRs).

サイズ 価格(税別)  
JPY 18100
JPY 40880
JPY 116800
最寄りの販売代理店を探す

お探しのディーラーが見当たらない場合は直接こちらのメールアドレスまでお問い合わせください:[email protected].co.jp

バルク問合せ

文献中Selleckの製品使用例(166)

製品安全説明書

ATM/ATR阻害剤の選択性比較

生物活性

製品説明 Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Chloroquine is also an inhibitor of toll-like receptors (TLRs).
ターゲット
TLR3 [4]
()
TLR7 [4]
()
TLR8 [4]
()
TLR9 [4]
()
ATM [1]
(Cell-free assay)
体外試験

Chloroquine is a chemotherapeutic agent for the clinical treatment of malaria. Chloroquine is able to bind to DNA, and inhibit DNA replication and RNA synthesis which in turn results in cell death. The effect of Chloroquine may also be related to the formation of a toxic heme-Chloroquine complex. Chloroquine inhibits trophozoite hemoglobin degradation through increasing vacuolar pH and inhibiting the activity of vacuolar phospholipase, vacuolar proteases, and heme polymerase[1]. Chloroquine possesses definite antirheumatic properties. Chloroquine has immuno-modulatory effects, suppressing the production/release of tumour necrosis factor and interleukin 6. Moreover, Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best-studied effects are those against HIV replication[2]. Chloroquine can accumulate inside the macrophage phagolysosome by ion trapping where it exerts potent antifungal activity against Histoplasma capsulatum and Cryptococcus neoformans by distinct mechanisms. Chloroquine inhibits growth of H. capsulatum by pH-dependent iron deprivation, whereas it is directly toxic to C. neoformans[3].

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human K562 cells NHK4UGtEgXSxdH;4bYPDqGG|c3H5 NGH3cmFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OD1|MT64N{BvVQ>? NVjjNlNCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1N|g2PjdpPkG4OVM5PTZ5PD;hQi=>
human KB cells M2r6cWN6fG:2b4jpZ:Kh[XO|YYm= M1rxTWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGtDKGOnbHzzJIJ6KG2rY4LvdIxifGVibXX0bI9lNCCLQ{WwQVAvPiEQvF2= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDZ2MEWyOEc,OTR4NEC1NlQ9N2F-
human MDA-MB-468 cells MlXQR5l1d3SxeHnjxsBie3OjeR?= NFf3c3I1QCCq NG\aNXhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtOFY5KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmgbY4heHKnc3XuZ4Uhd2ZiMz61JJVOKDRvKEKtZ4htd3KxLUGwTE1xcGWwb4jhfolvNTFyLYnsLU1PNE5vZHnleIh6dGK3dHHuMVEu[W2rbnWgbJllem:laHzvdoll\SxiR1m1NF0zNjhzIN88US=> MkTUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7NEWxPVcoRjF7OUS1NVk4RC:jPh?=
human MCF7 cells M3qyZmN6fG:2b4jpZ:Kh[XO|YYm= NUT1WFJoPDhiaB?= Mn2yR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5JIlvKHC{ZYPlcoNmKG:oIECuOEB2VSBzLTixMUg1NSh5LYDo[Y56dC1zSD3pcYll[XqxW{SsOU1oZXG3aX7vfIFtcW5vNj35cElj\W68eXypdIlx\XKrZHnuMVQugWxrLUHIMYJmdnqxW3TdbY1q\GG8b3ytNkg{UClvb37lMEBIUTVyPUWuOVEh|ryP MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl2NUG5O{c,OTl7NEWxPVc9N2F-
human MDA-MB-231 cells NETP[VdEgXSxdH;4bYPDqGG|c3H5 M3TJelQ5KGh? MYHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XliaX6gdJJme2WwY3Wgc4YhOy53IIXNJFQuMDJvY3jsc5JwNTFySD3wbIVvd3ijennuMVExNXmuKT3OMG4u\GmndHj5cIJ2fGGwLUGtZY1qdmViaInkdo9kcGyxcnnk[UwhT0l3ME22MlA5KM7:TR?= M3[xfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUS1NVk4Lz5zOUm0OVE6PzxxYU6=
human HeLa cells NF7qVmdEgXSxdH;4bYPDqGG|c3H5 MX;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGK7IF3UWEBie3OjeTygTWM2OD1|MDFOwG0> M1;yZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{W0N|IzLz5{NEO1OFMzOjxxYU6=
human HepG2 cells M1zSeGN6fG:2b4jpZ:Kh[XO|YYm= M1\qO|Q5KGh? NIf1XlVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVM4NjZ6IN88US=> M1X2XFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEG1NVg3Lz5{M{ixOVE5PjxxYU6=
mammary tumor FM3A M{Owd2N6fG:2b4jpZ4l1gSCjc4PhfS=> NGO2N3REgXSxdH;4bYNqfHlib3[gZ49ueG:3bnSge4F{KHSnc4Tl[EBi\2GrboP0JI1wfXOnIH3hcY1ienlidIXtc5IhTk1|QTDj[YxteyxiRVO1NEA:KDBwMECwNFAxOyEQvF2u M4XhO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{NUewN|g2Lz5zMkW3NFM5PTxxYU6=
red blood cells NHfnPIJCdnSrcHzhd41w\GmjbDDhd5NigQ>? NWnSXZA2PDhiaILz MkLiRY51cXCuYYPtc4Rq[WxiYXP0bZZqfHliYXfhbY5{fCCSbHHzcY9lcXWvIH\hcINqeGG{dX2gSoNDOS:Fb3z1cYJq[SCrbn\lZ5Rm\CCrbjDoeY1idiC{ZXSgZoxwd2RiY3XscJMh[XO|ZYPz[YQh[XNicHHyZZNqfGViZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPDhiaILzJIJ6KFt|SG2tbJlxd3ijboTobY5mKGmwY3;ydI9z[XSrb36gZZN{[XluIFnDOVAhRSByLkCwNFEyKM7:TT6= NYHpNmZTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2OVk4PzBpPkK1OlU6PzdyPD;hQi=>
red blood cells MlPrRY51cXCuYYPtc4Rq[WxiYYPzZZk> M{PtfFQ5KGi{cx?= MmnRRY51cXCuYYPtc4Rq[WxiYXP0bZZqfHliYXfhbY5{fCClaHzvdo9yfWmwZTDhcoQheHm{aX3leIhidWmwZT3y[ZNqe3SjboSgdolv\yC|dHHn[UBRdGG|bX;kbZVuKG[jbHPpdIFzfW1iVkGvV{Bqdm[nY4Tl[EBqdiCqdX3hckBz\WRiYnzvc4Qh[2WubIOgZYZ1\XJiNEigbJJ{NCCLQ{WwJF0hOC5yMEW1JO69VS5? NGLZ[WY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUKwO|k{Pyd-MkGyNFc6Ozd:L3G+
red blood cells NWq4UII5SW62aX3hcIFzcWGuIHHzd4F6 NVrV[VVsSW62aX3hcIFzcWGuIHHjeIl3cXS7IHHnZYlve3RiUHzhd41w\Gm3bTDveoFt\SC{aX7nJJN1[WenIHnu[oVkfGWmIHnuJJJm\CCkbH;v[EBk\WyuczDpckBxemW|ZX7j[UBw\iCDQjugbJVu[W5ic3XyeY0h[nliZIL1[{B{fXOlZYD0bYJqdGm2eTDhd5NigSxiSVO1NEA:KDBwMEC3PEDPxE1w NX[5OJpsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC5N|c4PzlpPkKwPVM4Pzd7PD;hQi=>
red blood cells NFHQb3BCdnSrbXHsZZJq[WxiYYPzZZk> M4XMPFQ5KGi{cx?= NWPaO5FOSW62aX3hcIFzcWGuIHHjeIl3cXS7IHHnZYlve3RiY3jsc5JweXWrbnWtd4Vve2m2aY\lJIVzgXSqcn;jfZRq[yC|dHHn[UBw\iCSbHHzcY9lcXWvIH\hcINqeGG{dX2gUmY2PCCrbn\lZ5Rm\CCrbjDoeY1idiC{ZXSgZoxwd2RiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPDhiaILzJIJ6KFt|SG2tbJlxd3ijboTobY5mKGmwY3;ydI9z[XSrb36gZZN{[XluIFnDOVAhRSByLkCwPVQh|ryPLh?= NIXXTpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[4OVU3QSd-MkO2PFU2Pjl:L3G+
red blood cells NGLycW1CdnSrbXHsZZJq[WxiYYPzZZk> NGnxUHI1QCCqcoO= NWLWT4lbSW62aX3hcIFzcWGuIHHjeIl3cXS7IHHnZYlve3RiY3jsc5JweXWrbnWtd4Vve2m2aY\lJHBt[XOvb3TpeY0h\mGuY3nwZZJ2dSCGNjDpcoZm[3SnZDDpckBpfW2jbjDPJJBwe2m2aY\lJJJm\CCkbH;v[EBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIGuzTH0ucHmyb4jhcpRpcW6nIIXweIFs\SCjZoTldkA1QCCqcoOsJGlEPTBiPTCwMlAyKM7:TT6= MnvIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFzNUW1PVMoRjJzMUW1OVk{RC:jPh?=
red blood cells MUjBcpRqdWGuYYLpZYwh[XO|YYm= NGT6WVRCdnSrbXHsZZJq[WxiYXP0bZZqfHliYXfhbY5{fCClaHzvdo9yfWmwZT3z[Y5{cXSrdnWgVIxie22xZHn1cUBn[WylaYDhdpVuKER4IHnu[oVkfGWmIHnuJJJm\CCkbH;v[EBk\WyuczDh[pRmeiB5MjDodpMh[nliTXHsd5RifCC{ZXHn[Y51KGKjc3XkJGxFUCCjc4PhfUwhUUN3MDC9JFAvODFzIN88UU4> NV7rZpp6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyNlI{OTdpPkK4NlIzOzF5PD;hQi=>
red blood cells NFzEdohCdnSrbXHsZZJq[WxiYYPzZZk> NEPVW2c4OiCqcoO= M{\qRWFvfGmvYXzhdolidCCjY4Tpeol1gSCjZ3HpcpN1KGOqbH;yc5F2cW6nLYPlcpNqfGm4ZTDQcIF{dW:maYXtJIZidGOrcHHyeY0hO0R5IHnu[oVkfGWmIHnuJIh2dWGwIIT5dIUhSS2yb4PpeIl3\SC{ZXSgZoxwd2RiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KHOyZXP0do9xcG:2b33leJJq[2GubImsJGlEPTBiPTCwMlAyOiEQvF2u NXjrWmRXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzNVE2PjJpPkK1N|EyPTZ{PD;hQi=>
red blood cells NWXzUXR6SW62aX3hcIFzcWGuIHHzd4F6 NUnFZ5E4SW62aX3hcIFzcWGuIHHjeIl3cXS7IHHnZYlve3RiUHzhd41w\Gm3bTDtZYxiemmjZTDybY5oKHO2YXflJIlv\mWldHXkJIlvKHKnZDDicI9w\CClZXzsd{BqdiCycnXz[Y5k\SCxZjDBRkshcHWvYX6gd4VzfW1iYomg[JJ2\yC|dYPj[ZB1cWKrbHn0fUBie3OjeTygTWM2OCB;IECuNFE1KM7:TT6= MmLIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB7M{e3O|koRjJyOUO3O|c6RC:jPh?=
red blood cells MmrhRY51cXCuYYPtc4Rq[WxiYYPzZZk> Mnr3OFghcHK| MYHBcpRqeGyjc33v[IlidCCjY4Tpeol1gSCjZ3HpcpN1KGOqbH;yc5F2cW6nLYPlcpNqfGm4ZTygcYVndG:zdXnu[U1z\XOrc4ThcpQhemmwZzDzeIFo\SCSbHHzcY9lcXWvIH\hcINqeGG{dX2gSFYhcW6oZXP0[YQhcW5iaIXtZY4hemWmIHLsc49lKGOnbHzzJIFnfGW{IES4JIhzeyxiSVO1NEA:KDBwMEG0NkDPxE1w NVXmWZZ5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGyNFc6OzdpPkKxNlA4QTN5PD;hQi=>
red blood cells MYjBcpRqeGyjc33v[IlidCCjc4PhfS=> NVnLXmJLPzJiaILz NIn1[2VCdnSrcHzhd41w\GmjbDDhZ5Rqfmm2eTDh[4FqdnO2IHPocI9zd3G3aX7lMZNmdnOrdHn2[UBRdGG|bX;kbZVuKG[jbHPpdIFzfW1iREGwJIlv\mWldHXkJIlvKGi3bXHuJJJm\CCkbH;v[EBk\WyuczDh[pRmeiB5MjDodpMh[nlicHHyZZNqfGVibHHjeIF1\SCmZXj5[JJw\2WwYYPlJIF{e2G7LDDJR|UxKD1iMD6wNVQ{KM7:TT6= MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjlzN{i1O{c,OjJ7MUe4OVc9N2F-
red blood cells NHmzWHVCdnSrcHzhd41w\GmjbDDhd5NigQ>? Mon1OFghcHK| NG\rWJVCdnSrcHzhd41w\GmjbDDhZ5Rqfmm2eTDh[4FqdnO2IHHz[Zh2[WxiZYL5eIhzd2O7dHWgd5Ri\2Vib3[gZ4htd3KxcYXpcoUue2Wwc3n0bZZmKFCuYYPtc4RqfW1iZnHsZ4lx[XK3bTDOSlU1KGmwZnXjeIVlKGmwIHj1cYFvKHKnZDDicI9w\CClZXzsd{Bi\nSncjC0PEBpenNiYomgcIFkfGG2ZTDk[Yh6\HKxZ3XuZZNmKGG|c3H5MEBKSzVyIE2gNE4xOTZizszNMi=> NX:4SphERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyPVY3QDNpPkOwNlk3Pjh|PD;hQi=>
red blood cells NVfLRoNjSW62aX3hcIFzcWGuIHHzd4F6 NXfMNpdqQTZiaILz NIG2T|lCdnSrbXHsZZJq[WxiYXP0bZZqfHliYXfhbY5{fCC5aXzkJJR6eGViZXHycJkhfHKxcHjvfo9qfGVic4Th[4Uhd2ZiUHzhd41w\Gm3bTDmZYxkcXCjcoXtJGQ3KGmwIHj1cYFvKHKnZDDicI9w\CClZXzsd{Bie3Onc4Pl[EBieyCdM1jdbJlxd3ijboTobY5mKHWydHHr[UBi\nSncjC5OkBpenNuIFnDOVAhRSByLkCxO{DPxE1w NULqUIE3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0OFgzQDFpPkKzOFQ5OjhzPD;hQi=>
FM3A NHX5VnRHfW6ldHnvckBie3OjeR?= M3PrT3NmdGWldHn2bZR6KG[xcjDGUVNCKGOnbHzzJI93\XJiUHzhd41w\Gm3bTDmZYxkcXCjcoXtJIF{KG2nYX6gSWM2OCC{YYTpc{whUUN3MDC9JFAvODF7IN88UU4> MoXyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ2MEi3NFgoRjF{NEC4O|A5RC:jPh?=
red blood cells MnTYRY51cW2jbHHybYFtKGG|c3H5 MWK0PEBpenN? NFHXeFdCdnSrbXHsZZJq[WxiYXP0bZZqfHliYXfhbY5{fCClaHzvdo9yfWmwZT3z[Y5{cXSrdnWgVIxie22xZHn1cUBn[WylaYDhdpVuKDOGNzDpcoZm[3SnZDDpckBpfW2jbjDPJJBwe2m2aY\lJJJm\CCkbH;v[EBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIGuzTH0ucHmyb4jhcpRpcW6nIIXweIFs\SCjZoTldkA1QCCqcoOsJGlEPTBiPTCwMlAzKM7:TT6= NHrtfXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUG1OVU6Oyd-MkGxOVU2QTN:L3G+
red blood cells NFzOVodCdnSrbXHsZZJq[WxiYYPzZZk> NUi2WnhTPzJiaILz NEG2UJJCdnSrbXHsZZJq[WxiYXP0bZZqfHliYXfhbY5{fCClaHzvdo9yfWmwZT3z[Y5{cXSrdnWgVIxie22xZHn1cUBn[WylaYDhdpVuKERzMDDpcoZm[3SnZDDpckBpfW2jbjD0fZBmKEFvcH;zbZRqfmVicnXkJIJtd2:mIHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSC|cHXjeJJweGixdH;t[ZRzcWOjbHz5MEBKSzVyIE2gNE4xOiEQvF2u NGH0PYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUOxNVU3Oid-MkWzNVE2PjJ:L3G+
red blood cells MXfBcpRqdWGuYYLpZYwh[XO|YYm= NVjYbndkSW62aX3hcIFzcWGuIHHjeIl3cXS7IHHnZYlve3Ricnnu[{B{fGGpZTDQcIF{dW:maYXtJIZidGOrcHHyeY0hO0R5IHnu[oVkfGWmIIfpeIghcHWvYX6gdoVlKGKub3;kJINmdGy|IHnuZ5Vj[XSnZDDmc5IhPDhiaILzJIJ6KFO\QmKgS5Jm\W5ibXX0bI9lNCCLQ{WwJF0hOC5yMkOg{txONg>? NV\sTWFbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3NlU3ODhpPkK1O|I2PjB6PD;hQi=>
red blood cells NEHqenZCdnSrbXHsZZJq[WxiYYPzZZk> MlHQRY51cW2jbHHybYFtKGGldHn2bZR6KGGpYXnud5QhWGyjc33v[Il2dSCxdnHs[UB1em:yaH;6c4l1\SC|dHHn[UBqdm[nY4Tl[EBqdiC{ZXSgZoxwd2RiY3XscJMhcW5icILld4Vv[2Vib3[gRWIsKGi3bXHuJJNmenWvIHL5JIRzfWdic4XzZ4VxfGmkaXzpeJkh[XO|YYmsJGlEPTBiPTCwMlAzOzJizszNMi=> MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODl|N{e3PUc,OjB7M{e3O|k9N2F-
red blood cells NX7QfHdFSW62aX3hcIFzcWGuIHHzd4F6 MVvBcpRqdWGuYYLpZYwh[WO2aY\peJkh[WejaX7zeEBRdGG|bX;kbZVuKG[jbHPpdIFzfW1iM1S3JGEhcW6oZXP0[YQhcW5icnXkJIJtd2:mIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhYzOKXXj5dI95[W62aHnu[UBqdmOxcoDvdoF1cW:wIHHmeIVzKDJ2IHjyd{BjgSC|Y3nueIltdGG2aX;uJINwfW62aX7nMEBKSzVyIE2gNE4xOjRizszNMi=> NGHCNJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwNFI3OSd-MkS5NFAzPjF:L3G+
red blood cells MnXqRY51cW2jbHHybYFtKGG|c3H5 NHvHSmU1QCCqcoO= M3zGO2FvfGmvYXzhdolidCCjY4Tpeol1gSCjZ3HpcpN1KGOqbH;yc5F2cW6nLYPlcpNqfGm4ZTDQcIF{dW:maYXtJIZidGOrcHHyeY0hVmmpZYLpZY4hcW6oZXP0[YQhcW5iaIXtZY4hemWmIHLsc49lKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDbN2heNWi7cH;4ZY51cGmwZTDpcoNwenCxcnH0bY9vKGG|c3H5MEBKSzVyIE2gNE4xOjVizszNMi=> NEe1XpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEiwNFQ2QCd-Mki4NFA1PTh:L3G+
red blood cells NH\UXnNCdnSrcHzhd41w\GmjbDDhd5NigQ>? MYe0PEBpenN? NYDtfJF4SW62aYDsZZNud2SrYXygZYN1cX[rdImgZYdicW6|dDDjbIxwem:zdXnu[U1{\W6|aYTpeoUhWGyjc33v[Il2dSCoYXzjbZBienWvIEPEO{Bqdm[nY4Tl[EBqdiCqdX3hckBz\WRiYnzvc4Qh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIIDhdoF{cXSnIHfyc5d1cCCjZoTldkA1QCCqcoOgZpkhUG:nY3jzeEA{OzN2MjDzeIFqdmmwZzDiZZNm\CCobH;3JIN6fG:vZYTybYMh[W6jbInzbZMtKEmFNUCgQUAxNjB{NjFOwG0v MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODF7OUewOkc,OzBzOUm3NFY9N2F-
HCT-8 MnzwRY51cW2rY4LvZolidCCjc4PhfS=> NVnWRWtVPDhiaILz MVzBcpRqdWmlcn;ibYFtKGGldHn2bZR6KGGpYXnud5QhS3K7cITvd5BwemmmaYXtJJBien[3bTDpcoZm[3SnZDDpckBpfW2jbjDIR3QuQCClZXzsd{Bi\nSncjC0PEBpenNiYomgSWxKW0FuIFnDOVAhRSByLkCyO{DPxE1w MnS3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3OUGyPFAoRjF6NUmxNlgxRC:jPh?=
red blood cells NGKzepJCdnSrbXHsZZJq[WxiYYPzZZk> M3TvelczKGi{cx?= M4jtWWFvfGmvYXzhdolidCCjY4Tpeol1gSCjZ3HpcpN1KGOqbH;yc5F2cW6nLYPlcpNqfGm4ZTDQcIF{dW:maYXtJIZidGOrcHHyeY0hTDFyIHnu[oVkfGWmIHnuJIh2dWGwIIT5dIUhSS2yb4PpeIl3\SC{ZXSgZoxwd2RiY3XscJMh[XO|ZYPz[YQh[XNicHHyZZNqfGVibHHjeIF1\SCmZXj5[JJw\2WwYYPlJIFkfGm4aYT5JIFnfGW{IEeyJIhzeyCkeTDzdIVkfHKxcHjveI9u\XS{aXOgZY5idHm|aYOsJGlEPTBiPTCwMlAzQSEQvF2u M3ntWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MEW0NFM5Lz5{MkC1OFA{QDxxYU6=
red blood cells MnTNRY51cW2jbHHybYFtKGG|c3H5 NV;UVJd6PzJiaILz NFTES2ZCdnSrbXHsZZJq[WxiYXP0bZZqfHliYXfhbY5{fCClaHzvdo9yfWmwZT3z[Y5{cXSrdnWgVIxie22xZHn1cUBn[WylaYDhdpVuKERzMDDpcoZm[3SnZDDpckBpfW2jbjDBMZBwe2m2aY\lJJJm\CCkbH;v[EBk\WyuczDh[pRmeiB5MjDodpMh[nlibHHjeIF1\SCmZXj5[JJw\2WwYYPlJIF{e2G7LDDJR|UxKD1iMD6wN{DPxE1w NITZPYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUGyN|A4PCd-MkGxNlMxPzR:L3G+
red blood cells MmDGRY51cW2jbHHybYFtKGG|c3H5 Mn;yRY51cW2jbHHybYFtKGGldHn2bZR6KGGpYXnud5Qh[2iub4LvdZVqdmVvc3Xud4l1cX[nIGDsZZNud2SrdX2g[oFt[2myYYL1cUA{TDdiaX7m[YN1\WRiaX6gdoVlKGKub3;kJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCVWVLSJIdz\WWwIEGgd5RicW6rbnegZoF{\WRiZnz1c5JwdWW2cnnjJIF{e2G7LDDJR|UxKD1iMD6wN{DPxE1w MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZ7MkizNUc,Ojd4OUK4N|E9N2F-
3D7 MVTBcpRqeGyjc33v[IlidCCjc4PhfS=> NV3pTFZwSW62aYDsZZNud2SrYXygZYN1cX[rdImgZYdicW6|dDDQcIF{dW:maYXtJIZidGOrcHHyeY0hO0R5IILpcoche3SjZ3WgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJJBiemG|aYTlcYliKGK7IF3hcJN1[XRiYYPzZZktKEmFNUCgQUAxNjB|IN88UU4> NFrRd5Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mki1PFMxOCd-MkK4OVg{ODB:L3G+
red blood cells NF7pe45CdnSrbXHsZZJq[WxiYYPzZZk> MYTBcpRqdWGuYYLpZYwh[WO2aY\peJkh[WejaX7zeEBRdGG|bX;kbZVuKG[jbHPpdIFzfW1iM1S3RUBqdm[nY4Tl[EBqdiC{ZXSgZoxwd2RiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBx[XKjc3n0[UBoem:5dHigZYZ1\XJiMkSgbJJ{KGK7IGuzTH1pgXCxeHHueIhqdmViaX7jc5Jxd3KjdHnvckBie3OjeTygTWM2OCB;IECuNFM3KM7:TT6= NESwXZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUmwOlIxOCd-MkW5NFYzODB:L3G+
red blood cells M{fJNGFvfGmvYXzhdolidCCjc4PhfS=> NHfaeJVCdnSrbXHsZZJq[WxiYXP0bZZqfHliYXfhbY5{fCClaHzvdo9yfWmwZT3z[Y5{cXSrdnWgVIxie22xZHn1cUBn[WylaYDhdpVuKER4IHnu[oVkfGWmIHnuJIh2dWGwIILl[EBjdG:xZDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4heGG{YYPpeIlkKEyGSDDhZ5Rqfmm2eTDifUBO[Wy|dHH0JJJm[WenboSgZoF{\WRic4DlZ5Rzd3Cqb4TvcYV1emmlIH3leIhw\CxiSVO1NEA:KDBwMESg{txONg>? M3vXOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OECwOFU5Lz5{OEiwNFQ2QDxxYU6=
red blood cells NEjmfWNCdnSrcHzhd41w\GmjbDDhd5NigQ>? MYjBcpRqeGyjc33v[IlidCCjY4Tpeol1gSCjZ3HpcpN1KGOqbH;yc5F2cW6nLYPlcpNqfGm4ZTDQcIF{dW:maYXtJIZidGOrcHHyeY0hTDZiaX7m[YN1\WRiaX6gdoVlKGKub3;kJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPYXzzeIF1KHKnYXflcpQh[mG|ZXSgUGRJKGG|c3H5MEBKSzVyIE2gNE4xPCEQvF2u NFruVms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEOxOVU6QCd-MkizNVU2QTh:L3G+
red blood cells NWHxSWs6SW62aYDsZZNud2SrYXygZZN{[Xl? M{L1WGFvfGmybHHzcY9lcWGuIHHjeIl3cXS7IHHnZYlve3RiY3jsc5JweXWrbnWtd4Vve2m2aY\lJHBt[XOvb3TpeY0h\mGuY3nwZZJ2dSCGNjDpcoZm[3SnZDDpckBz\WRiYnzvc4Qh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IIDhdoF{cXSrYzDMSGgh[XO|YYmsJGlEPTBiPTCwMlA1KM7:TT6= NHHy[pU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwNFUxQSd-MkS5NFA2ODl:L3G+
Vero MVXBcpRqdWGuYYLpZYwh[XO|YYm= NHfLPVc4OiCqcoO= MX7BcpRqdWGuYYLpZYwh[WO2aY\peJkh[WejaX7zeEBkcGyxcn;xeYlv\S2|ZX7zbZRqfmViUHzhd41w\Gm3bTDmZYxkcXCjcoXtJGQ3KGmwZnXjeIVlKGmwIFHmdolk[W5iZ4Ll[Y4hdW:wa3X5JEhE\XKlb4DpeIhm[3W|IHHleIhqd3C|KTDW[ZJwKGOnbHzzJIF{e2W|c3XkJIF{KHCjcnHzbZRmKEyGSDDhZ5Rqfmm2eTDh[pRmeiB5MjDodpMtKEmFNUCgQUAxNjB3IN88UU4> NF\tW4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUizN|UzOCd-MUm4N|M2OjB:L3G+
red blood cells NH71UXpCdnSrcHzhd41w\GmjbDDhd5NigQ>? MlrKOEBpenN? NWHPOZRISW62aYDsZZNud2SrYXygZYN1cX[rdImgZYdicW6|dDDQcIF{dW:maYXtJIZidGOrcHHyeY0hcW5iaIXtZY4hemWmIHLsc49lKGOnbHzzJIFnfGW{IESgbJJ{NCCLQ{WwJF0hOC5yNUWg{txONg>? MornQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7OUC4OlUoRjF5OUmwPFY2RC:jPh?=
red blood cells M2XURmFvfGmybHHzcY9lcWGuIHHzd4F6 NHHa[G01QCCqcoO= MmnJRY51cXCuYYPtc4Rq[WxiYXP0bZZqfHliYXfhbY5{fCClaHzvdo9yfWmwZT3z[Y5{cXSrdnWgdolv\yC|dHHn[UBRdGG|bX;kbZVuKG[jbHPpdIFzfW1iM1S3JIlv\mWldHXkJIlvKGi3bXHuJJJm\CCkbH;v[EBk\WyuczDh[pRmeiB2ODDodpMtKEmFNUCgQUAxNjB6OTFOwG0v NVTxdpkzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGyNFc6OzdpPkKxNlA4QTN5PD;hQi=>
B-cells NH7j[|VHfW6ldHnvckBie3OjeR?= NVy0R2xtS2:wY3XueJJifGmxbjDy[ZF2cXKnZDDmc5IhcGGuZj3tZZhqdWGuIHnubIljcXSrb36gc4YhS3CJLV;EUkBm\m[nY4Sgc44hfGi7bXnkbY5mKHWydHHr[UBjgSCZRVjJJFI{OSCvdYLpcoUhSi2lZXzsd{BqdiC2aHWgdJJme2WwY3Wgc4Yh[WyyaHGtd2loVS5uIFXDOVAhRSByLkGxJO69VS5? MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODRyNk[0PEc,OTB2ME[2OFg9N2F-
red blood cells NHjCZYFCdnSrcHzhd41w\GmjbDDhd5NigQ>? MYO0PEBpenN? MlHpRY51cXCuYYPtc4Rq[WxiYXP0bZZqfHliYXfhbY5{fCClaHzvdo9yfWmwZTDhcoQheHm{aX3leIhidWmwZTDy[ZNqe3SjboSgVIxie22xZHn1cUBn[WylaYDhdpVuKEtzIHnu[oVkfGWmIHnuJIh2dWGwIILl[EBjdG:xZDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4heGG{YYPpeIUhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUBcO0ifLXj5dI95[W62aHnu[UBqdmOxcoDvdoF1cW:wIHHzd4F6NCCLQ{WwJF0hOC5zMjFOwG0v M1THTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{S2PFE3Lz5{NUe0OlgyPjxxYU6=
red blood cells NUn3PZBDSW62aYDsZZNud2SrYXygZZN{[Xl? MX[0PEBpenN? NGPmZ|FCdnSrcHzhd41w\GmjbDDhZ5Rqfmm2eTDh[4FqdnO2IHPocI9zd3G3aX7lM5B6emmvZYToZY1qdmVvcnXzbZN1[W62IGDsZZNud2SrdX2g[oFt[2myYYL1cUBMOSCrbn\lZ5Rm\CCrbjDoeY1idiC{ZXSgZoxwd2RiY3XscJMh[XO|ZYPz[YQh[XNiW{PIYU1pgXCxeHHueIhqdmViaX7jc5Jxd3KjdHnvckBqdmO3YnH0[YQh\m:{IES4JIhzeyCycnnvdkB1dyCdM1jdMYh6eG:6YX70bIlv\SCjZHTpeIlwdiCvZXHzeZJm\CCjZoTldkAzPCCqcoOgZpkhdGluIFnDOVAhRSByLkGyOUDPxE1w MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJ4OEW0N{c,OjR{Nki1OFM9N2F-
red blood cells NH72V|RCdnSrbXHsZZJq[WxiYYPzZZk> MXrBcpRqdWGuYYLpZYwh[WO2aY\peJkh[WejaX7zeEBRdGG|bX;kbZVuKG2jbHHybYFmKHS{b4Doc5pwcXSnIIP0ZYdmKGmwZnXjeIVlKGmwIILl[EBjdG:xZDDj[YxteyCrbjDwdoV{\W6lZTDv[kBCSitiaIXtZY4he2W{dX2gZpkh\HK3ZzDzeZNk\XC2aXLpcIl1gSCjc4PhfUwhUUN3MDC9JFAvOTJ5OTFOwG0v NG\neYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEmzO|c4QSd-MkC5N|c4Pzl:L3G+
red blood cells MX7BcpRqdWGuYYLpZYwh[XO|YYm= MYW0PEBpenN? NILue3RCdnSrbXHsZZJq[WxiYXP0bZZqfHliYXfhbY5{fCClaHzvdo9yfWmwZT3y[ZNqe3SjboSgVIxie22xZHn1cUBn[WylaYDhdpVuKE[lQkGgbY5n\WO2ZXSgbY4hcHWvYX6gdoVlKGKub3;kJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCdM1jdMYh6eG:6YX70bIlv\SCrbnPvdpBwemG2aX;uJIF{e2G7LDDJR|UxKD1iMD6xN|Ih|ryPLh?= MnqwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh6MEC0OVgoRjJ6OECwOFU5RC:jPh?=
red blood cells NHLSOoRCdnSrcHzhd41w\GmjbDDhd5NigQ>? M3v1b|Q5KGi{cx?= M37ycmFvfGmybHHzcY9lcWGuIHHjeIl3cXS7IHHnZYlve3RiY3jsc5JweXWrbnWtdoV{cXO2YX70JJJqdmdic4Th[4UhWGyjc33v[Il2dSCoYXzjbZBienWvIGeyJIlv\mWldHXkJIlvKGi3bXHuJJJm\CCkbH;v[EBk\WyuczDh[pRmeiB2ODDodpMtKEmFNUCgQUAxNjF|ODFOwG0v NUWwPZhXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGyNFc6OzdpPkKxNlA4QTN5PD;hQi=>
red blood cells NHi0OYlCdnSrcHzhd41w\GmjbDDhd5NigQ>? MV20PEBpenN? MYLBcpRqeGyjc33v[IlidCCjY4Tpeol1gSCjZ3HpcpN1KGOqbH;yc5F2cW6nLYLld4l{fGGwdDDQcIF{dW:maYXtJIZidGOrcHHyeY0hXzJiaX7m[YN1\WRiaX6gbJVu[W5icnXkJIJtd2:mIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhemmwZz3zeIFo\SCyYYLhd4l1\SCpcn;3eIgh[W[2ZYKgOFghcHK|IHL5JIZtd3diY4n0c41mfHK7LDDJR|UxKD1iMD6xOEDPxE1w MmTuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF{OUW4PFcoRjJzMkm1PFg4RC:jPh?=
RPMI1640 M2PnRWFvfGmyYYLhd4l1cWNiYYPzZZk> MXm3NkBpenN? MnvuRY51cXCjcnHzbZRq[yCjY4Tpeol1gSCjZ3HpcpN1KGOqbH;yc5F2cW6nLYLld4l{fGGwdDDldpl1cHKxY4n0bYMhe3SjZ3Wgc4YhWGyjc33v[Il2dSCoYXzjbZBienWvIFuxJIlv\mWldHXkJIlvKGi3bXHuJHJRVUlzNkSwJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCQQmSgd5RicW6rbnegZoF{\WRic4DlZ5Rzd3Olb4DpZ{BidmGueYPpd{whUUN3MDC9JFAvOTRizszNMi=> NXPEWpNqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[5NlIzOjZpPkK2PVIzOjJ4PD;hQi=>
red blood cells M4DMdmFvfGmybHHzcY9lcWGuIHHzd4F6 MkPpOFghcHK| M{X1XWFvfGmybHHzcY9lcWGuIHHjeIl3cXS7IHHnZYlve3RiY3jsc5JweXWrbnWvdJlzcW2ndHjhcYlv\SC{ZYPpd5RidnRiUHzhd41w\Gm3bTDmZYxkcXCjcoXtJGsyKGmwZnXjeIVlKGmwIHj1cYFvKHKnZDDicI9w\CClZXzsd{Bi\nSncjC0PEBpenNiYomgX|NJZWi7cH;4ZY51cGmwZTDpcoNwenCxcnH0bY9vKGG|c3H5MEBKSzVyIE2gNE4yPSEQvF2u MmKwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd|NESyNVUoRjJ5M{S0NlE2RC:jPh?=
red blood cells MYjBcpRqeGyjc33v[IlidCCjc4PhfS=> MkHlOFghcHK| MoLyRY51cXCuYYPtc4Rq[WxiYXP0bZZqfHliYXfhbY5{fCCjc3X4eYFtKGW{eYTodo9kgXSnIIP0ZYdmKG:oIHPocI9zd3G3aX7lMZJme2m|dHHueEBRdGG|bX;kbZVuKG[jbHPpdIFzfW1iRHSyJIlv\mWldHXkJIlvKGi3bXHuJJJm\CCkbH;v[EBk\WyuczDh[pRmeiB2ODDodpMh[nlibHHjeIF1\SCmZXj5[JJw\2WwYYPlJIF{e2G7LDDJR|UxKD1iMD6xOUDPxE1w NGD4[pU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEK5OlY5Oyd-M{CyPVY3QDN:L3G+
red blood cells NGHhbo5CdnSrbXHsZZJq[WxiYYPzZZk> NVr3co84PDhiaILz M2\ZXWFvfGmvYXzhdolidCCjY4Tpeol1gSCjZ3HpcpN1KG23bITp[JJ2\y2{ZYPpd5RidnRiUHzhd41w\Gm3bTDmZYxkcXCjcoXtJGsyKGmwZnXjeIVlKGmwIHj1cYFvKHKnZDDicI9w\CClZXzsd{Bie3Onc4Pl[EBieyB|SD3ofZBwgGGwdHjpcoUhcW6lb4Lwc5JifGmxbjDh[pRmeiB2ODDodpMh[nlibHnxeYllKHOlaX70bYxt[XSrb36gZ492dnSrbnesJGlEPTBiPTCwMlE4KM7:TT6= NXPGO5pORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2OFQ2PDFpPkKxOlQ1PTRzPD;hQi=>
L6 NF70V4ZCdnSrcHHyZZNqfGmlIHHzd4F6 MlXkOFghcHK| MXjBcpRqeGG{YYPpeIlkKGGldHn2bZR6KGGpYXnud5QhWGyjc33v[Il2dSCoYXzjbZBienWvIFuxJIlv\mWldHXkJIlvKHKjdDDMOkBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIIDhdoF{cXSnIHfyc5d1cCCycnXpcoN2[mG2ZXSg[o9zKDR6IHjyd{Bj\W[xcnWgX|NJZWi7cH;4ZY51cGmwZTDh[IRqfGmxbjDt[YF{fXKnZDDh[pRmeiB{NDDodpMh[nliW{PIYYh6eG:6YX70bIlv\SCrbnPvdpBwemG2aX;uJIF{e2G7LDDJR|UxKD1iMD6xO|gh|ryPLh?= MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl|N{KyPEc,OjF7M{eyNlg9N2F-
L6 MYLDfZRwfG:6aXPpeJkh[XO|YYm= NUL5WHdjS3m2b4TvfIlkcXS7IHHnZYlve3RicnH0JGw3KGOnbHzzJIJ6KGGuYX3hdkBjdHWnIHHzd4F6NCCLQ{WwJF0hOC5zOEi1JO69VS5? NHLrcYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G3PFE4Pyd-MUexO|gyPzd:L3G+
red blood cells MVXBcpRqeGyjc33v[IlidCCjc4PhfS=> MnfwOFghcHK| NF:4fVNCdnSrcHzhd41w\GmjbDDhZ5Rqfmm2eTDh[4FqdnO2IITo[UBufWy2aXTyeYcuemW|aYP0ZY51KFCuYYPtc4RqfW1iZnHsZ4lx[XK3bTDGVmMuOyCrbn\lZ5Rm\CCrbjDoeY1idiC{ZXSgZoxwd2RiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJJBiemG|aYTlJIdzd3e2aDDh[pRmeiB2ODDodpMh[nliSH;lZ4h{fCB|M{O0NkB{fGGrbnnu[{Bj[XOnZDDmcI94KGO7dH;t[ZRzcWNiYX7hcJl{cXNuIFnDOVAhRSByLkKwO{DPxE1w MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODF7OUewOkc,OzBzOUm3NFY9N2F-
red blood cells MX;BcpRqdWGuYYLpZYwh[XO|YYm= NV\DbGhkPDhiaILz NH[wfHRCdnSrbXHsZZJq[WxiYXP0bZZqfHliYXfhbY5{fCClaHzvdo9yfWmwZT3y[ZNqe3SjboSg[ZJ6fGi{b3P5eIlkKHO2YXflJI9nKFCuYYPtc4RqfW1iZnHsZ4lx[XK3bTDLNUBqdm[nY4Tl[EBqdiCqdX3hckBz\WRiYnzvc4Qh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgOFghcHK|IHL5JHs{UF1vaInwc5hidnSqaX7lJIlv[2:{cH;yZZRqd25iYYPzZZktKEmFNUCgQUAxNjJzIN88UU4> MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ6NUW2PUc,OjN4OEW1Olk9N2F-
red blood cells NFXmUGxCdnSrcHzhd41w\GmjbDDhd5NigQ>? NWW5OJRbPDhiaILz MlvQRY51cXCuYYPtc4Rq[WxiYXP0bZZqfHliYXfhbY5{fCClaHzvdo9yfWmwZT2gZY5lKHC7cnnt[ZRp[W2rbnWtdoV{cXO2YX70JHBt[XOvb3TpeY0h\mGuY3nwZZJ2dSCNMTDpcoZm[3SnZDDpckBpfW2jbjDy[YQh[myxb3SgZ4VtdHNiYYPz[ZN{\WRiYYOgX|NJZWi7cH;4ZY51cGmwZTDpcoNwenCxcnH0bY9vKGGodHXyJFQ5KGi{czDifUBtcXG3aXSgd4NqdnSrbHzheIlwdiClb4XueIlv\yxiSVO1NEA:KDBwMkKg{txONg>? NHvrdoc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUSzPFU5Pid-MkG0N|g2QDZ:L3G+
red blood cells NXHmOnBOSW62aX3hcIFzcWGuIHHzd4F6 M3K4cGFvfGmvYXzhdolidCCjY4Tpeol1gSCjZ3HpcpN1KHKrbnegd5Ri\2ViUHzhd41w\Gm3bTDmZYxkcXCjcoXtJHczKGmwZnXjeIVlKHerdHigbJVu[W5icnXkJIJtd2:mIHPlcIx{KGmwY4XiZZRm\CCob4KgOFghcHK|IHL5JIZtd3diY4n0c41mfHK7LDDJR|UxKD1iMD6yNlkh|ryPLh?= MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd{NU[wPEc,OjV5MkW2NFg9N2F-
L6 NWD5eIE6SW62aYDhdoF{cXSrYzDhd5NigQ>? NFzSc5RCdnSrcHHyZZNqfGmlIHHjeIl3cXS7IHHnZYlve3RiY3jsc5JweXWrbnWsJJB6emmvZYToZY1qdmVvcnXzbZN1[W62IGDsZZNud2SrdX2g[oFt[2myYYL1cUBMOSCncon0bJJw[3m2ZTDzeIFo\SCrbn\lZ5Rm\CC{YYSgUFYh[2WubIOsJGlEPTBiPTCwMlI{KM7:TT6= MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzl2OUC2PEc,OTd7NEmwOlg9N2F-
L6 MWPBcpRqeGyjc33v[IlidCCjc4PhfS=> MnP2RY51cXCuYYPtc4Rq[WxiYXP0bZZqfHliYXfhbY5{fCClaHzvdo9yfWmwZTDhcoQheHm{aX3leIhidWmwZT3y[ZNqe3SjboSgVIxie22xZHn1cUBn[WylaYDhdpVuKEtzIHnu[oVkfGWmIHnuJJJifCCONjDj[YxteyxiSVO1NEA:KDBwMkWg{txONg>? MlrmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7NEK0N|koRjF7OUSyOFM6RC:jPh?=
red blood cells NXHGTY1uSW62aX3hcIFzcWGuIHHzd4F6 NVrrRmFKPzJiaILz NWrjVGlVSW62aX3hcIFzcWGuIHHjeIl3cXS7IHHnZYlve3RiY3jsc5JweXWrbnWtdoV{cXO2YX70JHBt[XOvb3TpeY0h\mGuY3nwZZJ2dSCZMjDpcoZm[3SnZDDpckBpfW2jbjDBMZBwe2m2aY\lJJJm\CCkbH;v[EBk\WyuczDh[pRmeiB5MjDodpMh[nlibHHjeIF1\SCmZXj5[JJw\2WwYYPlJIF{e2G7LDDJR|UxKD1iMD6yOUDPxE1w MmXsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFzMkOwO|QoRjJzMUKzNFc1RC:jPh?=
red blood cells NITKeY1CdnSrbXHsZZJq[WxiYYPzZZk> NIn1OJU1QCCqcoO= NH[x[GJCdnSrbXHsZZJq[WxiYXP0bZZqfHliYXfhbY5{fCClaHzvdo9yfWmwZT3y[ZNqe3SjboSgVIxie22xZHn1cUBn[WylaYDhdpVuKE[lTUK5JIlv\mWldHXkJIlvKGi3bXHuJJJm\CCkbH;v[EBk\WyuczDh[pRmeiB2ODDodpMh[nliW{PIYU1pgXCxeHHueIhqdmViaX7jc5Jxd3KjdHnvckBie3OjeTygTWM2OCB;IECuNlYh|ryPLh?= NU\Fd25xRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki4NFA1PThpPkK4PFAxPDV6PD;hQi=>
red blood cells M1:ze2FvfGmvYXzhdolidCCjc4PhfS=> MnrkOFghcHK| NIDyPWJCdnSrbXHsZZJq[WxiYXP0bZZqfHliYXfhbY5{fCCvdXz0bYRzfWdvcnXzbZN1[W62IGDsZZNud2SrdX2g[oFt[2myYYL1cUBVVTlyLVOyRkBqdm[nY4Tl[EBqdiCqdX3hckBQKHCxc3n0bZZmKHKnZDDicI9w\CClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJHs{UF1vaInwc5hidnSqaX7lJJVxfGGtZTDh[pRmeiB2ODDodpMtKEmFNUCgQUAxNjJ6IN88UU4> M{jIRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMUW1OVk{Lz5{MUG1OVU6OzxxYU6=
red blood cells MWnBcpRqdWGuYYLpZYwh[XO|YYm= NEHXWlM1QCCqcoO= Mn;lRY51cW2jbHHybYFtKGGldHn2bZR6KGGpYXnud5QhemmwZzDzeIFo\SCSbHHzcY9lcXWvIH\hcINqeGG{dX2gSIQzKGmwZnXjeIVlKHerdHigbJVu[W5icnXkJIJtd2:mIHPlcIx{KGmwY4XiZZRm\CCob4KgOFghcHK|IHL5JHN[SlJiR4Ll[Y4hdWW2aH;kMEBKSzVyIE2gNE4zQDVizszNMi=> NY\aN|VJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3NlU3ODhpPkK1O|I2PjB6PD;hQi=>
red blood cells NG\DW45CdnSrbXHsZZJq[WxiYYPzZZk> MYm5OkBpenN? MmnERY51cW2jbHHybYFtKGGldHn2bZR6KGGpYXnud5Qh[2iub4LvdZVqdmViYX7kJJB6emmvZYToZY1qdmVvcnXzbZN1[W62IHXhdox6KHS{b4Doc5pwcXSnIIP0ZYdmKG:oIGDsZZNud2SrdX2g[oFt[2myYYL1cUBYOiCrbjDoeY1idiC{ZXSgZoxwd2RiY3XscJMh[XO|ZYPz[YQh[XNiW{PIYYh6eG:6YX70bIlv\SC3cIThb4Uh[W[2ZYKgPVYhcHK|LDDJR|UxKD1iMD6yPUDPxE1w NXnEWFdMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0OFgzQDFpPkKzOFQ5OjhzPD;hQi=>
red blood cells NFz6NHFCdnSrbXHsZZJq[WxiYYPzZZk> MnrqO|IhcHK| M3nUfGFvfGmvYXzhdolidCCjY4Tpeol1gSCjZ3HpcpN1KGOqbH;yc5F2cW6nLYLld4l{fGGwdDDQcIF{dW:maYXtJIZidGOrcHHyeY0hXzJiaX7m[YN1\WRiaX6gbJVu[W5idInw[UBCNXCxc3n0bZZmKHKnZDDicI9w\CClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhe3CnY4Tyc5Bpd3SxbXX0dolk[WyueTygTWM2OCB;IECuN|E3KM7:TT6= MojTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV|MUG1OlIoRjJ3M{GxOVYzRC:jPh?=
red blood cells NVroUW5rSW62aX3hcIFzcWGuIHHzd4F6 M4e2clczKGi{cx?= MojwRY51cW2jbHHybYFtKGGldHn2bZR6KGGpYXnud5Qh[2iub4LvdZVqdmVvcnXzbZN1[W62IGDsZZNud2SrdX2g[oFt[2myYYL1cUBYOiCrbn\lZ5Rm\CCrbjDy[YQh[myxb3SgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2jbIP0ZZQhemWjZ3XueEBj[XOnZDDMSGgh[XO|YYmsJGlEPTBiPTCwMlMyPyEQvF2u NVjySFlZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyNlI{OTdpPkK4NlIzOzF5PD;hQi=>
red blood cells NFHrNHJCdnSrcHzhd41w\GmjbDDhd5NigQ>? NXf0WogxPzJiaILz NGDDSppCdnSrcHzhd41w\GmjbDDhZ5Rqfmm2eTDh[4FqdnO2IHPocI9zd3G3aX7lMZJme2m|dHHueEBRdGG|bX;kbZVuKG[jbHPpdIFzfW1iV{KgbY5n\WO2ZXSgbY4hcHWvYX6gdoVlKGKub3;kJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCyYYLhd4l1\SCuYXP0ZZRmKGSnaInkdo9o\W6jc3WgZZN{[XluIFnDOVAhRSByLkOxO|Eh|ryPLh?= Mo\YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7MUe4OVcoRjJ{OUG3PFU4RC:jPh?=
red blood cells MnnmRY51cXCuYYPtc4Rq[WxiYYPzZZk> NWfGeVBwPzJiaILz MoDDRY51cXCuYYPtc4Rq[WxiYXP0bZZqfHliYXfhbY5{fCClaHzvdo9yfWmwZT3y[ZNqe3SjboSgVIxie22xZHn1cUBn[WylaYDhdpVuKFd{IHnu[oVkfGWmIHnuJJJm\CCkbH;v[EBk\WyuczDh[pRmeiB5MjDodpMh[nlicHHyZZNqfGmlIFzETEBie3OjeTygTWM2OCB;IECuN|kh|ryPLh?= NInVcFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwNFUxQSd-MkS5NFA2ODl:L3G+
red blood cells NI\WZZlCdnSrbXHsZZJq[WxiYYPzZZk> NITnZ3U1QCCqcoO= NX3KVFFoSW62aX3hcIFzcWGuIHHjeIl3cXS7IHHnZYlve3RiY3jsc5JweXWrbnWgZY5lKHC7cnnt[ZRp[W2rbnWtdoV{cXO2YX70JHBt[XOvb3TpeY0h\mGuY3nwZZJ2dSCNMTDpcoZm[3SnZDDpckBpfW2jbjDPJJBwe2m2aY\lJJJm\CCkbH;v[EBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIGuzTH0ucHmyb4jhcpRpcW6nIIXweIFs\SCjZoTldkA1QCCqcoOsJGlEPTBiPTCwMlQh|ryPLh?= NGn4TWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUG1OVU6Oyd-MkGxOVU2QTN:L3G+
red blood cells MXXBcpRqdWGuYYLpZYwh[XO|YYm= NVnXbo9vSW62aX3hcIFzcWGuIHHjeIl3cXS7IHHnZYlve3RiY3jsc5JweXWrbnWtdoV{cXO2YX70JHBt[XOvb3TpeY0h\mGuY3nwZZJ2dSCZMjDpcoZm[3SnZDDpckBpfW2jbjDy[YQh[myxb3SgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKHCjcnHzbZRq[yCORFigZYN1cX[rdImgZpkhVWGuc4TheEBz\WGpZX70JIJie2WmIIPw[YN1em:yaH;0c41mfHKrYzDt[ZRpd2RuIFnDOVAhRSByLkSyJO69VS5? Mlm5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh6MEC0OVgoRjJ6OECwOFU5RC:jPh?=
red blood cells Mn\URY51cXCuYYPtc4Rq[WxiYYPzZZk> NYXoS206PzJiaILz NF3xTJVCdnSrcHzhd41w\GmjbDDhZ5Rqfmm2eTDh[4FqdnO2IHPocI9zd3G3aX7lMZJme2m|dHHueEBRdGG|bX;kbZVuKG[jbHPpdIFzfW1iV{KgbY5n\WO2ZXSgbY4hemWmIHLsc49lKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNZYx{fGG2IILlZYdmdnRiYnHz[YQhVESKIHHzd4F6NCCLQ{WwJF0hOC52MzFOwG0v NHXiRnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEOxOVU6QCd-MkizNVU2QTh:L3G+
Vero M1vLTWFvfGmvYXzhdolidCCjc4PhfS=> M2e0WlczKGi{cx?= MUfBcpRqdWGuYYLpZYwh[WO2aY\peJkh[WejaX7zeEBkcGyxcn;xeYlv\S2{ZYPpd5RidnRiUHzhd41w\Gm3bTDmZYxkcXCjcoXtJHczKGmwZnXjeIVlKGmwIFHmdolk[W5iZ4Ll[Y4hdW:wa3X5JEhE\XKlb4DpeIhm[3W|IHHleIhqd3C|KTCoR4Vz[2:yaYTo[YN2eyCjZYTobY9xeyliVnXyc{Bk\WyuczDhd5Nme3OnZDDhd{Bx[XKjc3n0[UBNTEhiYXP0bZZqfHliYX\0[ZIhPzJiaILzMEBKSzVyIE2gNE41QDRizszNMi=> MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTh|M{WyNEc,OTl6M{O1NlA9N2F-
HEK293 MlrPR5l1d3SxeHnjbZR6KGG|c3H5 MnmwO|IhcHK| Mn\ZR5l1d3SxeHnjbZR6KGGpYXnud5QhUEWNMkmzJINmdGy|IHHmeIVzKDd{IHjyd{BjgSC{ZYPhfpVzcW5iZInlJIJie2WmIHHzd4F6NCCLQ{WwJF0hOC52OTFOwG0v MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJ|NkS5Nkc,Ojl{M{[0PVI9N2F-
red blood cells NYPTfpI6SW62aX3hcIFzcWGuIHHzd4F6 NWHzeY1{PzJiaILz NVrHOGhNSW62aX3hcIFzcWGuIHHjeIl3cXS7IHHnZYlve3RiY3jsc5JweXWrbnWtdoV{cXO2YX70JHBt[XOvb3TpeY0h\mGuY3nwZZJ2dSCZMjDpcoZm[3SnZDDpckBpfW2jbjD0fZBmKEFvcH;zbZRqfmVicnXkJIJtd2:mIHPlcIx{KGG|c3Xzd4VlKGG|IIDhdoF{cXSnIHzhZ5RifGViZHXofYRzd2enbnHz[UBi[3Srdnn0fUBi\nSncjC3NkBpenNiYomgd5Bm[3S{b4Doc5RwdWW2cnnjJIFv[Wy7c3nzMEBKSzVyIE2gNE42OiEQvF2u MkO0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyNUSwN|goRjJ{MEW0NFM5RC:jPh?=
red blood cells NYe0R5JTSW62aYDsZZNud2SrYXygZZN{[Xl? M3zWdVQ5KGi{cx?= M1rGRWFvfGmybHHzcY9lcWGuIHHjeIl3cXS7IHHnZYlve3RiY3jsc5JweXWrbnWtdoV{cXO2YX70JHBt[XOvb3TpeY0h\mGuY3nwZZJ2dSCZMjDpcoZm[3SnZDDpckBpfW2jbjDy[YQh[myxb3SgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFO\QmKgeIV{fCxiSVO1NEA:KDBwNUmg{txONg>? MnzCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ7OEizNFMoRjJ4OUi4N|A{RC:jPh?=
red blood cells NGjROpVCdnSrbXHsZZJq[WxiYYPzZZk> Mm\vOFghcHK| MoXlRY51cW2jbHHybYFtKGGldHn2bZR6KGGpYXnud5QhdXWudHnkdpVoNXKnc3nzeIFvfCCSbHHzcY9lcXWvIH\hcINqeGG{dX2gWG06Oy2FMUC4PEBqdm[nY4Tl[EBqdiCqdX3hckBQKHCxc3n0bZZmKHKnZDDicI9w\CClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJHs{UF1vaInwc5hidnSqaX7lJJVxfGGtZTDh[pRmeiB2ODDodpMtKEmFNUCgQUAxNjZ{IN88UU4> MoT3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFzNUW1PVMoRjJzMUW1OVk{RC:jPh?=
Dd2 NHHWSVVCdnSrcHzhd41w\GmjbDDhd5NigQ>? NGC3UplCdnSrcHzhd41w\GmjbDDhZ5Rqfmm2eTDh[4FqdnO2IHTyeYchemW|aYP0ZY51KFCuYYPtc4RqfW1iZnHsZ4lx[XK3bTDE[FIhemmwZzDzeIFo\SClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25icHHyZZNqfGWvaXGgZpkhVWGuc4TheEBie3OjeTygTWM2OCB;IECuO|Eh|ryPLh?= MnTrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6NUizNFAoRjJ{OEW4N|AxRC:jPh?=
red blood cells M3;QdWFvfGmvYXzhdolidCCjc4PhfS=> MXq3NkBpenN? MmfPRY51cW2jbHHybYFtKGGldHn2bZR6KGGpYXnud5Qh[2iub4LvdZVqdmVvcnXzbZN1[W62IGDsZZNud2SrdX2g[oFt[2myYYL1cUBYOiCrbn\lZ5Rm\CCrbjDy[YQh[myxb3SgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KFO\QmKg[5Jm\W5iMTDzeIFqdmmwZzDiZZNm\CCobIXvdo9u\XS{aXOgZZN{[XluIFnDOVAhRSByLke1JO69VS5? M1K4OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NkmyPFMyLz5{N{[5Nlg{OTxxYU6=
red blood cells NWLpRVFuSW62aX3hcIFzcWGuIHHzd4F6 M2jV[FQ5KGi{cx?= MYPBcpRqdWGuYYLpZYwh[WO2aY\peJkh[WejaX7zeEBkcGyxcn;xeYlv\SxicInybY1mfGijbXnu[Uwh[W6mIH3l[oxweXWrbnWtdoV{cXO2YX70JHBt[XOvb3TpeY0h\mGuY3nwZZJ2dSCGZEKgbY5n\WO2ZXSgbY4hcHWvYX6gU{Bxd3OrdHn2[UBz\WRiYnzvc4Qh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDbN2heNWi7cH;4ZY51cGmwZTD1dJRic2ViYX\0[ZIhPDhiaILzMEBKSzVyIE2gNE46QCEQvF2u MlK3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFzNUW1PVMoRjJzMUW1OVk{RC:jPh?=
HepG2 MknTR5l1d3SxeHnjbZR6KGG|c3H5 MV:3NkBpenN? MlPzR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh\XiycnXzd4lv\yCFREixJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKt[4xwKGG|c3H5MEBESzVyIE2gNU43KM7:TT6= MkLaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5OUG2O|UoRjJ3N{mxOlc2RC:jPh?=
HepG2 M{n2WmFvfGmybHHzcY9lcWGuIHHzd4F6 M3;HOVQ5KGi{cx?= NHzHT5JCdnSrcHzhd41w\GmjbDDhZ5Rqfmm2eTDh[4FqdnO2IHzpeoVzKHO2YXflJI9nKFCuYYPtc4RqfW1ieX;lcIlqKDF5WDDOUEB{eG:{b4rvbZRmeyCrbn\lZ5Rm\CCrbjDoeY1idiCKZYDHNkBk\WyuczDlfJBz\XO|aX7nJGNFQDFiYX\0[ZIhPDhiaILzJIJ6KESDUFmgd5RicW6rbnetZoF{\WRiaX3teY5w\my3b4Lld4NmdmOnIHHuZYx6e2m|LDDJR|UxKD1iMT62OUDPxE1w M2H2OFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{mxOlc2Lz5{NUe5NVY4PTxxYU6=
WI38 NVeyPZE5SW62aY\pdoFtKGG|c3H5 M4m1e|IhcHK| M3PsZ2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGJMXiCJYYLkcoVzKEGWQ1OgWnI5OzdiaX7m[YN1\WRiaX6gbJVu[W5iV1mzPEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyZYwhTE6DIHzleoVtKHC{ZXnuZ5Vj[XSnZDDmc5IhOiCqcoOgZoVnd3KnII\pdoFtKGmwZnXjeIlwdiCvZXHzeZJm\CCjZoTldkA4KGSjeYOgZpkhemWjbDD0bY1mKFCFUjDhd5NigSxiRVO1NEA:KDFwNzFOwG0v NYPHUGVRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe4PVMyPThpPkG3PFk{OTV6PD;hQi=>
HeLa MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXrsVWFIPDhiaILz Mn;lS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gTIVN[SClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5JIlvKHC{ZYPlcoNmKG:oIEGwNEB2VSCcblPsNkwhT0l3MDC9JFIvOSEQvF2u M1HvOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7N{S4O|g3Lz5zOUe0PFc5PjxxYU6=
SMB M{SyWmFvfGmycnnvckBie3OjeR?= NULIcXRGSW62aYDybY9vKGGldHn2bZR6KGGpYXnud5QhS2ijbnTs[ZIhe3S{YXnuJI9nKHOqZXXwJJNkemGyaXWgdJJqd25icILveIVqdiCrbn\lZ5Rm\CCrbjDtc5V{\SCVTVKgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4xm[XKjbnPlJI9nKGSrc3Xhd4Uu[XO|b3PpZZRm\CC|Y4LhdIlmKHC{aX;uJJBzd3SnaX6sJGVEPTBiPTCyMlMh|ryPLh?= NUnoSnhpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1O|A5OzdpPkKxOVcxQDN5PD;hQi=>
HEK293 NWn1S2V{TnWwY4Tpc44h[XO|YYm= NUfLZpd6UW6qaXLpeIlwdiCxZjDoeY1idiCHUleg[ZhxemW|c3XkJIlvKEiHS{K5N{Bk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idHHpcEBkfXK{ZX70JIF1KG2nbXLyZY5mKHCxdHXueIlidCCxZjCrNlAhdVZuIFnDOVAhRSB{LkWg{txONg>? MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd2NkixOkc,OjV5NE[4NVY9N2F-
red blood cells MYHBcpRqdWGuYYLpZYwh[XO|YYm= MlHiNlQhcHK| MULBcpRqdWGuYYLpZYwh[WO2aY\peJkh[WejaX7zeEBkcGyxcn;xeYlv\S2|ZX7zbZRqfmViUHzhd41w\Gm3bTDmZYxkcXCjcoXtJFNFPyCrbn\lZ5Rm\CCrbjDy[YQh[myxb3SgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKG2jdIXy[UB{[2iren;ueJMh\m:{bXH0bY9vKGGodHXyJFI1KGi{czDifUBIcWWvc3Gtd5RicW6rbnegZoF{\WRiYYPzZZktKEWFNUCgQUAzNjl5IN88UU4> M3;p[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEm5OFg3Lz5{OUS5PVQ5PjxxYU6=
HEK293 NHvyS4VHfW6ldHnvckBie3OjeR?= M3vlfIhGWkdiYnnu[Ilv\yCjc4PhfZM7KESrc4DsZYNmdWWwdDDv[kBcO0ifLVTv[oV1cWyrZHWgLFUhdk1iZnnuZYwqKG[{b32gbGVTTyCvZX3idoFv\XNib3L0ZYlv\WRiZoLvcUBJTUt{OUOgZ4VtdHNuIFvpJF0hOy5zNkKyPEDPxE1w MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OjN3M{i1PUc,OzJ|NUO4OVk9N2F-
1205 Lu M4K1TWN6fG:2b4jpZ4l1gSCjc4PhfS=> M3XZVVczKGi{cx?= NF\4RpFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckAyOjB3IFz1JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB|Lk[g{txONg>? NYr0enFPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PVkyPTdpPkK1Olk6OTV5PD;hQi=>
LN229 M3nPSGN6fG:2b4jpZ4l1gSCjc4PhfS=> NHvLdI04OiCqcoO= MkT1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUG4zOjliY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFMvPiEQvF2u MorjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4OUmxOVcoRjJ3Nkm5NVU4RC:jPh?=
C8161 MV\DfZRwfG:6aXPpeJkh[XO|YYm= NXHKPXhMPzJiaILz NH3DTWNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBEQDF4MTDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOy54IN88UU4> MnLHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4OUmxOVcoRjJ3Nkm5NVU4RC:jPh?=
HT-29 MXXDfZRwfG:6aXPpeJkh[XO|YYm= NYewTmZDPzJiaILz M4DpZmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhVNTJ7IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{NjZizszNMi=> Mmm1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4OUmxOVcoRjJ3Nkm5NVU4RC:jPh?=
WI38 MYXDfZRwfG:6aXPpeJkh[XO|YYm= NGTMTm0zPCCqcoO= NX7Nd21iS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hX0l|ODDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHC{b3zp[oVz[XSrb36gZYZ1\XJiMkSgbJJ{KGK7IGPSRkBie3OjeTygTWM2OCB;IEOuOlMh|ryPLh?= M1LjT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NE[xN|A6Lz5{NUS2NVMxQTxxYU6=
ScN2a MlLuSpVv[3Srb36gZZN{[Xl? M2rTWGhidGZibXH4bY1idCCrbnjpZol1cW:wIH;mJHBzcW:wIIDyc5RmcW5iUILQd4Mh\m:{bXH0bY9vKHejczDhd5NigWWmIHnuJHNkVjKjIHPlcIx{NCCHQ{WwJF0hPCEQvF2u MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjlyNEC1PUc,OTJ7MESwOVk9N2F-
HepG2 NFLZeFZEgXSxdH;4bYNqfHliYYPzZZk> MknjNlQhcHK| M1v1SmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFI1KGi{czDifUBv\XW2cnHsJJJm\CCmeXWgeZB1[WunIHHzd4F6NCCWQ{WwJF0hPC5|IN88UU4> MnHNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5OEO5PFQoRjJ{N{izPVg1RC:jPh?=
HeLa MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYW0PEBpenN? NHzRPVhIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJ\UyjIHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZkhcW5icILld4Vv[2Vib3[gOVAhfU1iQ4XDcFItKEeLNUCgQUA1NjRizszNMi=> NXu2elIyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3OFg4QDZpPkG5O|Q5Pzh4PD;hQi=>
HeLa NYDhb4t2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlLPOFghcHK| MV\Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmgbY4heHKnc3XuZ4Uhd2ZiMUCgeW0hS3WFbEKsJGdKPTBiPTC1MlMh|ryPLh?= NXzjSXdnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3OFg4QDZpPkG5O|Q5Pzh4PD;hQi=>
HeLa M2nS[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUXHe3BwPDhiaILz MVvHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmgbY4heHKnc3XuZ4Uhd2ZiNUCgeW0hYm6FbEKsJGdKPTBiPTC1MlYh|ryPLh?= NELiS489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUe0PFc5Pid-MUm3OFg4QDZ:L3G+
HeLa Mn;jS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUjJNmdZPDhiaILz NHPuS3VIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJ\UyjIHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZkhcW5icILld4Vv[2Vib3[gNUB2VSCFdVPsNkwhT0l3MDC9JFYvOSEQvF2u Mnv5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5NEi3PFYoRjF7N{S4O|g3RC:jPh?=
SH-SY5Y M1LhcmZ2dmO2aX;uJIF{e2G7 MmfHNlQhcHK| MYDNc4R2dGG2aX;uJI9nKGi3bXHuJJdqdGRvdInw[UBCWFB4OUWg[ZhxemW|c3XkJIlvKFOKLWPZOXkh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDhcZltd2mmIHLleIEhMDFidH:gOFAhemW|aXT1[ZMqKHC{b3T1Z5Rqd25ibXXhd5Vz\WRiYX\0[ZIhOjRiaILzMEBKSzVyIE2gO{DPxE1w MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV3OUG5PEc,Ojl3NUmxPVg9N2F-
SH-SY5Y M3fjSmZ2dmO2aX;uJIF{e2G7 M2Xh[lI1KGi{cx?= NYD0NodIUW6qaXLpeIlwdiCxZjDCRWNGOSCrbjDoeY1idiCVSD3TXVV[KGOnbHzzJIhiemKxcnnu[{B4cWymIIT5dIUhSVCSNkm1JIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDhcZltd2mmIHLleIEhMDFidH:gOFAqKGyndnXsJIFnfGW{IEK0JIhzeyCkeTDFUGlUSSCvZYToc4QtKEmFNUCgQUA4KM7:TT6= NVPDb|F1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyOlg5OjJpPkOwNlY5QDJ{PD;hQi=>
CHO MnG0SpVv[3Srb36gZZN{[Xl? NHnzTpRKdmirYnn0bY9vKG:oIHj1cYFvKEWURzDlfJBz\XO|ZXSgbY4hS0iRIHPlcIx{NCCNaTC9JFcvPSEQvF2u NEHpUno9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwNFYxOyd-MkS5NFA3ODN:L3G+
L6 MV7DfZRwfG:6aXPpeJkh[XO|YYm= M{fNPWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KEx4IHPlcIx{NCCLQ{WwJF0hPy55IN88UU4> NHTuOlY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{K4NFg{PSd-MUeyPFA5OzV:L3G+
HepG2 MofzR5l1d3SxeHnjbZR6KGG|c3H5 NFzEPZU4OiCqcoO= MlS5R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JIFt[W2jcjDicJVmKGG|c3H5MEBKSzVyIE2gPE4{KM7:TT6= NV:wd3lERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGxOVU2QTNpPkKxNVU2PTl|PD;hQi=>
WI38 MkjQR5l1d3SxeHnjbZR6KGG|c3H5 MVGyJIhzew>? M13YRWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHdKOzhiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGy3bHHyJGRPSSCuZY\lcEBxemWrbnP1ZoF1\WRiZn;yJFIhcHK|IHLl[o9z\SC4aYLhcEBqdm[nY4Tpc44hdWWjc4Xy[YQh[W[2ZYKgO{Bl[Xm|IHL5JJJm[WxidHnt[UBRS1JiYYPzZZktKEOFNUCgQUA5NjVizszNMi=> MmS4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd6OUOxOVgoRjF5OEmzNVU5RC:jPh?=
HepG2 MmHrRY51cW2jbHHybYFtKGG|c3H5 MnflRY51cW2jbHHybYFtKGGldHn2bZR6KGGpYXnud5Qhe3Cxcn;6c4l1\SC|dHHn[UBw\iCSbHHzcY9lcXWvIHLldodp\WlieX;lcIlqKGmwZnXjeIVlKGmwIHj1cYFvKEincFeyJINmdGy|LDDJR|UxKD1iOTFOwG0v MmHnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ4NEC5PFEoRjJ4NkSwPVgyRC:jPh?=
SKHep M3ToNWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MX:0PEBpenN? MnHWS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gV2tJ\XBiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUBqdiCycnXz[Y5k\SCxZjCxNEUhTkKVIIP1dJBt\W2nboTl[EBFVUWPIH3l[Il2dSxiR1m1NEA:KDlwNTFOwG0v NYOyRpp6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3OFg4QDZpPkG5O|Q5Pzh4PD;hQi=>
HeLa M13WW2N6fG:2b4jpZ4l1gSCjc4PhfS=> M4DURVchcHK| M{nzPWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmVGFiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB{fXK4aY\hcEBi\nSncjC3JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC5MlY3PSEQvF2u MmC5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd5NkiwOVIoRjF5N{[4NFUzRC:jPh?=
HeLa NYLBVGZMS3m2b4TvfIlkcXS7IHHzd4F6 M3e1NFch\GG7cx?= NYrCe2J1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjZoTldkA4KGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hQS54NzFOwG0v MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTR6OUe4PUc,OjF2OEm3PFk9N2F-
K562 NXy1PWd{S3m2b4TvfIlkcXS7IHHzd4F6 M1XpOVI1KGi{cx?= NI\VOodEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGG|c3Xzd4VlKGG|IILh[Ilw[WO2aY\lJJRpgW2rZHnu[UBqdmOxcoDvdoF1cW:wIHHmeIVzKDJ2IHjyd{whS0N3MDC9JFkvPyEQvF2u Moe1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh4OECyO|goRjF6NkiwNlc5RC:jPh?=
Vero NF74UXNCdnSrdnnyZYwh[XO|YYm= Mmr3OkB1dyB5IHThfZM> NIjrSllCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBkcGmtdX7neY56[SC4aYL1d{BKdmSrYX6gc4Nm[W5ic4TyZYlvKDh7OTDpcoZm[3SnZDDpckBX\XKxIHPlcIx{KGG|c3Xzd4VlKGG|II\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgOkB1dyB5IHThfZMtKEWFNUCgQUAyOCEQvF2u NYLMNHMyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5O|A2PjFpPkK1PVcxPTZzPD;hQi=>
PDAC NGGz[4dHfW6ldHnvckBie3OjeR?= NG\4TpJKdmirYnn0bY9vKG:oIHPlcIwheHKxbHnm[ZJifGmxbjDv[kBRTEGFIHPlcIx{KCi3bnvuc5dvKG:{aXfpckktKEmFNUCgQUAyOCEQvF2u NEXWXlQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGzOVQ4OSd-Mk[xN|U1PzF:L3G+
Vero MX7BcpRqfmm{YXygZZN{[Xl? MlHjOkB1dyB5IHThfZM> M{XFfGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGNpcWu3bnf1cpliKH[rcoXzJFg6QSCrbn\lZ5Rm\CCrbjDB[pJq[2GwIHfy[YVvKG2xbnvlfUBX\XKxIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDj[YxtKGSnYYToJIFnfGW{IE[geI8hPyCmYYnzJIJ6KE2WUzDhd5NigSxiRVO1NEA:KDFyIN88UU4> MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl{NkiwO{c,OjR7Mk[4NFc9N2F-
HepG2 NGLFNFFEgXSxdH;4bYNqfHliYYPzZZk> M13s[VQ5KGi{cx?= NFP5NllEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA1QCCqcoOgZpkhS2WubGTpeIVzNUeubzDhd5NigSxiRVO1NEA:KDFyLkGg{txONg>? NXnz[lgxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm4NFA5OjdpPkK5PFAxQDJ5PD;hQi=>
BT-483 MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUO0RpZ3PDhiaILz MUnHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDCWE01QDNiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUBqdiCycnXz[Y5k\SCxZjCxNEUhTkKVIIP1dJBt\W2nboTl[EBFVUWPIH3l[Il2dSxiR1m1NEA:KDFyLkKg{txONg>? MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTd2OEe4Okc,OTl5NEi3PFY9N2F-
Vero MnX6RY51cX[rcnHsJIF{e2G7 M3uxXFUh\GG7cx?= M1qxdmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGNpcWu3bnf1cpliKH[rcoXzJGlv\GmjbjDPZ4VidiB6OEmgbY5n\WO2ZXSgbY4hSW[{aXPhckBoemWnbjDtc45s\XliVnXyc{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgOUBl[Xm|IHL5JG1VWy:STWOgcYV1cG:mLDDFR|UxKD1iMUGg{txONg>? NGize3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUOzOlk2OSd-MkmzN|Y6PTF:L3G+
Vero A MV7BcpRqfmm{YXygZZN{[Xl? NYrLT5V{PiC2bzC3JIRigXN? MXLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDbIlsfW6pdX75ZUB3cXK3czDJcoRq[W5ib3PlZY4he3S{YXnuJFg6QSCrbn\lZ5Rm\CCrbjDB[pJq[2GwIHfy[YVvKG2xbnvlfUBX\XKxIFGgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcnHsMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SgZYZ1\XJiNjD0c{A4KGSjeYOgZpkhVVSVL2DNV{Bie3OjeTygSWM2OCB;IEGxJO69VS5? MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZ5MUizNkc,Ojh4N{G4N|I9N2F-
Vero MUDBcpRqfmm{YXygZZN{[Xl? NVPsVoR6PSCmYYnz NGLHW3BCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEcGmtdX7neY56[SC4aYL1d{BKdmSrYX6gU4Nm[W5ic4TyZYlvKDh7OTDpcoZm[3SnZDDpckBC\nKrY3HuJIdz\WWwIH3vcotmgSCYZYLvJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEBu\WG|dYLl[EBwdiCmYYmgOUBxd3O2IHnu[oVkfGmxbjDifUBOXFNxUF3TJIF{e2G7LDDFR|UxKD1iMUGg{txONg>? NXvyfnBVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0PVk1QDdpPkK5OFk6PDh5PD;hQi=>
Vero NYnTWJVtSW62aY\pdoFtKGG|c3H5 NX;ENWE{PyCmYYnz MXrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDbIlsfW6pdX75ZUB3cXK3czDJcoRq[W5iT3PlZY4he3S{YXnuJFg6QSCrbn\lZ5Rm\CCrbjDB[pJq[2GwIHfy[YVvKG2xbnvlfUBX\XKxIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDh[pRmeiB5IHThfZMh[nliTWTTM3BOWyCvZYToc4QtKEWFNUCgQUAyOSEQvF2u MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDhyME[yOkc,OjR6MEC2NlY9N2F-
Vero NH;wc4lCdnSrdnnyZYwh[XO|YYm= NIPOV4c4KGSjeYO= NGTndHFCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBUcW6mYnnzJJZqenW|IIP0doFqdiCKUoPwJIlv\mWldHXkJIlvKGGocnnjZY4h\3KnZX6gcY9vc2W7IG\ldo8h[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2eyCrbnT1Z4VlKGOnbHyg[IVifGhibXXhd5Vz\WRiYX\0[ZIhPyCmYYnzMEBGSzVyIE2gNVEh|ryPLh?= NXLVfnA5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5OFYyOTZpPkK1PVQ3OTF4PD;hQi=>
Vero MWLBcpRqfmm{YXygZZN{[Xl? M1zuPVch\GG7cx?= NIK2dFlCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEcGmtdX7neY56[SC4aYL1d{B{fHKjaX6gPFk6KGmwZnXjeIVlKGmwIHHmdolk[W5iZ4Ll[Y4hdW:wa3X5JHZmem9iY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3czDpcoR2[2WmIHPlcIwh\GWjdHigcYVie3W{ZXSgZYZ1\XJiNzDkZZl{NCCHQ{WwJF0hOTFizszNMi=> MoXtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7NE[xNVYoRjJ3OUS2NVE3RC:jPh?=
Vero MmXxRY51cX[rcnHsJIF{e2G7 M1vMd|YhfG9iNzDkZZl{ NVTGe3g{SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhW2mwZHLpd{B3cXK3czDIVpNxKGmwZnXjeIVlKGmwIFHmdolk[W5iZ4Ll[Y4hdW:wa3X5JHZmem9iY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHPlcIwh\GWjdHigZYZ1\XJiNjD0c{A4KGSjeYOgZpkhVVSVIHHzd4F6NCCHQ{WwJF0hOTFizszNMi=> NXfYUYhKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NlY5ODdpPkK0PVI3QDB5PD;hQi=>
Vero Mkm4RY51cX[rcnHsJIF{e2G7 MVe2JJRwKDdiZHH5dy=> MYHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDTbY5l[mm|II\pdpV{KEiUc4CgbY5n\WO2ZXSgbY4h[W[{aXPhckBoemWnbjDtc45s\XliVnXyc{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5QhcW6ldXLheIVlKG[xcjC2JJRwKDdiZHH5d{BjgSCPVGOgZZN{[XluIFXDOVAhRSBzMTFOwG0v NHfqWpI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{KxOVQ3OCd-MkOyNVU1PjB:L3G+
Vero M3:wNmFvfGm4aYLhcEBie3OjeR?= NIHyUJQ3KHSxIEeg[IF6ew>? NEjMZlRCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEcGmtdX7neY56[SC4aYL1d{A5QTliaX7m[YN1\WRiaX6gZYZzcWOjbjDndoVmdiCvb37r[ZkhXmW{bzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SgbY5kfWKjdHXkJIZweiB4IITvJFch\GG7czDifUBOXFNiYYPzZZktKEWFNUCgQUAyOSEQvF2u M1vGeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MkG1OFYxLz5{M{KxOVQ3ODxxYU6=
red blood cells NI\LV|VCdnSrbXHsZZJq[WxiYYPzZZk> M3jPWFQ5KGi{cx?= M4jOTmFvfGmvYXzhdolidCCjY4Tpeol1gSCjZ3HpcpN1KGOqbH;yc5F2cW6nLYLld4l{fGGwdDDQcIF{dW:maYXtJIZidGOrcHHyeY0hUzF2IHnu[oVkfGWmIHnuJIh2dWGwIILl[EBjdG:xZDDj[YxteyCjZoTldkA1QCCqcoOgZpkhYzOKXXj5dI95[W62aHnu[UBqdmOxcoDvdoF1cW:wIHHzd4F6NCCLQ{WwJF0hOTFizszNMi=> NXjhN4p{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyPFIzPjBpPkK1NlgzOjZyPD;hQi=>
red blood cells M{P3bGFvfGmvYXzhdolidCCjc4PhfS=> MXOyOEBpenN? M4\0[GFvfGmvYXzhdolidCCjY4Tpeol1gSCjZ3HpcpN1KGOqbH;yc5F2cW6nLYLld4l{fGGwdDDQcIF{dW:maYXtJIZidGOrcHHyeY0hWkuOOTDpcoZm[3SnZDDpckBz\WRiYnzvc4Qh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIH3heJVz\SC|Y3jpfo9vfHNiZn;ycYF1cW:wIHHmeIVzKDJ2IHjyd{BjgSCJaXXtd4Eue3SjaX7pcoch[mG|ZXSgZZN{[XluIFXDOVAhRSBzMT6yOUDPxE1w NUXxNYNRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0PVk1QDZpPkK5OFk6PDh4PD;hQi=>
MCF7 MY\DfZRwfG:6aXPpeJkh[XO|YYm= MlPNR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyCdM1jdbJlxd3ijboTobY5mKGmwY3;ydI9z[XSrb36sJGlEPTBiPTCxNkDPxE1w NF;YfZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEWxNlk5Pyd-MUi1NVI6QDd:L3G+
HEK293 Mlz0R5l1d3SxeHnjbZR6KGG|c3H5 Mn;0O|IhcHK| MU\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDISWszQTNiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JIFt[W2jcjDicJVmKGG|c3H5MEBKSzVyIE2gNVIh|ryPLh?= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTF3NUW5N{c,OjFzNUW1PVM9N2F-
Vero NV\oS2FGSW62aY\pdoFtKGG|c3H5 MlHtNlQhcHK| NHXlVJJCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBbcWujII\pdpV{KGmwZnXjeIVlKGmwIFHmdolk[W5iZ4Ll[Y4hdW:wa3X5JHZmem9iY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXKjbDDSUmEhemWybHnjZZRqd25iYX\0[ZIhOjRiaILzJIJ6KFKWLWDDVkBu\XSqb3SsJGVEPTBiPTCxNkDPxE1w NE\Kd5c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC2PFYxPCd-MkiwOlg3ODR:L3G+
Vero Mmm2RY51cX[rcnHsJIF{e2G7 M{j6OVI1KGi{cx?= M2nzOmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JHpqc2FidnnyeZMhcW6oZXP0[YQhcW5iQX\ybYNidiCpcnXlckBud26tZYmgWoVzdyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqemGuIGLORUBz\XCuaXPheIlwdiCjZoTldkAzPCCqcoOgZpkhWlRvUFPSJI1mfGixZDygSWM2OCB;IEGyJO69VS5? MlzZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOUK4OVkoRjJ6MEmyPFU6RC:jPh?=
HeLa NWTCcmVlSW62aY\pdoFtKGG|c3H5 NVH5RXBqPDhiaILz MlTRRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgWnNXNUdicIPleYRwfHmyZXSgTGlXOSCuZX70bZZqemGuIIDhdpRq[2ynczDpcoZm[3SnZDDpckBpfW2jbjDI[WxiKGOnbHzzJIlv[3WkYYTl[EBnd3JiNEigbJJ{KGK7IIPw[YN1em:obIXvdo9u\XS{eTygTWM2OCB;IEGyMlQ5KM7:TT6= NF\HUow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mki1PFMxOCd-MkK4OVg{ODB:L3G+
SH-SY5Y NFi1UlVHfW6ldHnvckBie3OjeR?= MkS4NlQhcHK| NGXoVXFKdmirYnn0bY9vKG:oIFLBR2UyKGmwIHj1cYFvKFOKLWPZOXkh[2WubIOgbIFz[m:{aX7nJJdqdGRidInw[UBCWFB4OUWgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHHtfYxwcWRiYnX0ZUApOSC2bzC0NkkhdGW4ZXygZYZ1\XJiMkSgbJJ{KGK7IFXMTXNCKG2ndHjv[EwhUUN3MDC9JFEzNjdizszNMi=> MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJ4OEiyNkc,OzB{Nki4NlI9N2F-
SH-SY5Y M{XmTmZ2dmO2aX;uJIF{e2G7 M17rS|I1KGi{cx?= NWrsVFNKVW:mdXzheIlwdiCxZjDoeY1idiC5aXzkMZR6eGViQWDQOlk2KGW6cILld5Nm\CCrbjDTTE1UYTW\IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[W27bH;p[EBj\XSjIDixJJRwKDR{IILld4llfWW|KTDwdo9lfWO2aX;uJI1m[XO3cnXkJIFnfGW{IEK0JIhzeyCkeTDFUGlUSSxiSVO1NEA:KDF{Lkig{txONg>? NYfPNHZoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OVkyQThpPkK5OVU6OTl6PD;hQi=>
HepG2 NWnYR2xwS3m2b4TvfIlkcXS7IHHzd4F6 NILz[JE4OiCqcoO= NH3zOJZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA4OiCqcoOgZpkhSWyjbXHyJGJtfWViYYPzZZktKEmFNUCgQUAyOi57IN88UU4> MnTxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFzOUC4OVcoRjJzMUmwPFU4RC:jPh?=
Vero M4LseGFvfGm4aYLhcEBie3OjeR?= M2HaOVYhfG9iNzDkZZl{ MX7BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDT[Y1tcWurIH\vdoV{fCC4aYL1d{BXcWW2bnHtJIlv\mWldHXkJIlvKEGocnnjZY4h\3KnZX6gcY9vc2W7IG\ldo8h[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGOnbHyg[IVifGhiYX\0[ZIhPiC2bzC3JIRigXNiYomgUXRUKGG|c3H5MEBGSzVyIE2gNVMvQCEQvF2u MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl{NkiwO{c,OjR7Mk[4NFc9N2F-
Vero MVzBcpRqfmm{YXygZZN{[Xl? MojKO{Bl[Xm| NFPZXm5CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBU\W2uaXvpJIZwemW|dDD2bZJ2eyC|dILhbY4hXmmndH7hcUBqdm[nY4Tl[EBqdiCjZoLpZ4FvKGe{ZXXuJI1wdmuneTDW[ZJwKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNiaX7keYNm\CClZXzsJIRm[XSqIH3lZZN2emWmIHHmeIVzKDdiZHH5d{whTUN3MDC9JFE1KM7:TT6= MkPaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7NE[xNVYoRjJ3OUS2NVE3RC:jPh?=
Vero NVLjSYFVSW62aY\pdoFtKGG|c3H5 NVHJSm5wPiC2bzC3JIRigXN? NIfaW4RCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBU\W2uaXvpJIZwemW|dDD2bZJ2eyCrbn\lZ5Rm\CCrbjDh[pJq[2GwIHfy[YVvKG2xbnvlfUBX\XKxIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDpcoN2[mG2ZXSg[o9zKDZidH:gO{Bl[Xm|IHL5JG1VWyCjc4PhfUwhTUN3MDC9JFE1KM7:TT6= MkGzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{MUW0OlAoRjJ|MkG1OFYxRC:jPh?=
NSO NF\QO5NEgXSxdH;4bYNqfHliYYPzZZk> NFPEc5JEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBPW09iY3XscJMh[nliTWTUJIF{e2G7LDDUR|UxKD1iMUSuPUDPxE1w MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTFzM{m1OUc,OTlzMUO5OVU9N2F-
L1210 M16zXGN6fG:2b4jpZ4l1gSCjc4PhfS=> M2fu[2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGwyOjFyIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[2WubDDwdo9tcW[ncnH0bY9vKGK7IFPveYx1\XJiY3;1cpRmeiCjbnHsfZNqeyxiSVO1NEA:KDF3IN88UU4> NIXYc409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGxOFgyOSd-Mk[xNVQ5OTF:L3G+
Huh-7 NWWy[ldVSW62aYDsZZNud2SrYXygZZN{[Xl? NWXNOohpPDhiaILz NHG5V4xCdnSrcHzhd41w\GmjbDDhZ5Rqfmm2eTDh[4FqdnO2IGDsZZNud2SrdX2gZoVz\2inaTDsbZZmeiC|dHHn[UBnd3KvIITyZY5{\mWldHXkJIlvKGi3bXHuJGh2cC15IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFnDOVAhRSBzNT65JO69VS5? MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ5M{CzPEc,OjN{N{OwN|g9N2F-
Daudi NHHnXVNEgXSxdH;4bYNqfHliYYPzZZk> MnvWR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gSIF2\GliY3XscJMh[nliTWTUJIF{e2G7LDDUR|UxKD1iMU[uO{DPxE1w MofRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlzMUO5OVUoRjF7MUGzPVU2RC:jPh?=
HeLa MYLDfZRwfG:6aXPpeJkh[XO|YYm= M2OwOWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmVGFiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIIDyc4xq\mW{YYTpc44h[nliQ3;1cJRmeiClb4XueIVzKGGwYXz5d4l{NCCLQ{WwJF0hOThizszNMi=> MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjFzNEixNUc,OjZzMUS4NVE9N2F-
J774.1 M1fqNGN6fG:2b4jpZ4l1gSCjc4PhfS=> M4PDR|I1KGi{cx?= MUTDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDKO|c1NjFiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JGFt[W2jclLseYUh[mG|ZXSgZ5l1d3SxeHnjbZR6KGG|c3H5MEBKSzVyIE2gNVgvPCEQvF2u M2ribVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5M{G2OVQzLz5{N{OxOlU1OjxxYU6=
HeLa MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEfaXJQ1QCCqcoO= NXLyS2ZrT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUGWOYTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6KGmwIIDy[ZNmdmOnIH;mJFExLSCIQmOgd5VxeGynbXXueIVlKESPRV2gcYVlcXWvLDDHTVUxKD1iMUiuOkDPxE1w MlrCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5NEi3PFYoRjF7N{S4O|g3RC:jPh?=
MCF7 MXzDfZRwfG:6aXPpeJkh[XO|YYm= MUC0PEBpenN? MX7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGNEPTBiPTCxPU41KM7:TT6= NYjVRVZtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwNVQ5PTdpPkKwNFE1QDV5PD;hQi=>
MCF7 M3;wR2N6fG:2b4jpZ4l1gSCjc4PhfS=> MnfoOFghcHK| NXPNTYpZS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA1QCCqcoOgZpkhYFSWIILl[JVkfGmxbjDhd5NigSxiQ1O1NEA:KDF7LkSg{txONg>? MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ6NkCxN{c,OjR4OE[wNVM9N2F-
MCF7 Mkf5R5l1d3SxeHnjbZR6KGG|c3H5 MoPSOFghcHK| NX\TTmNqS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliWGTUJIF{e2G7LDDDR|UxKD1iMUmuOEDPxE1w NXW3dI1QRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PVQ2OjRpPkK0OVk1PTJ2PD;hQi=>
MDA-MB-468 MWnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NFuwW3k4OiCqcoO= MnqwRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuPDZ6IHPlcIx{KGGodHXyJFczKGi{czDifUBUWkJiYYPzZZktKEmFNUCgQUAyQS56NjFOwG0v M{XhcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NkCyPFI4Lz5{Nk[wNlgzPzxxYU6=
KB M{TESmN6fG:2b4jpZ4l1gSCjc4PhfS=> NF;IPI81QCCqcoO= MmPKR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT2Ih[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKwMlQh|ryPLh?= NUPPRXI1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG4NFkxPzVpPkGxPFA6ODd3PD;hQi=>
Vero NUL2fYRSSW62aY\pdoFtKGG|c3H5 MmfnOUBl[Xm| NVzMOWF[SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS2ira4Xu[5VvgWFidnnyeZMhUW6maXHuJG9k\WGwIEi4PUBqdm[nY4Tl[EBqdiCDZoLpZ4FvKGe{ZXXuJI1wdmuneTDW[ZJwKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCjZoTldkA2KGSjeYOgZpkhVVSVL2DNV{Bu\XSqb3SsJGVEQTBiPTCyNUDPxE1w NHnjSnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUOzOlk2OSd-MkmzN|Y6PTF:L3G+
Vero M2jnS2FvfGm4aYLhcEBie3OjeR?= MkXERY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR4hqc3WwZ4XufYEhfmm{dYOgTY5lcWGwIF;j[YFvKHO2cnHpckA5QTliaX7m[YN1\WRiaX6gRYZzcWOjbjDndoVmdiCvb37r[ZkhXmW{bzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SgcYVie3W{ZXSgc44h\GG7IEWgdI9{fCCrbn\lZ5Rqd25iYomgUXRUN1CPUzDhd5NigSxiRVO5NEA:KDJzIN88UU4> MkjqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2OUm0PFcoRjJ7NEm5OFg4RC:jPh?=
Vero M2jOVmFvfGm4aYLhcEBie3OjeR?= MmL2O{Bl[Xm| NWjDT5NWSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS2ira4Xu[5VvgWFidnnyeZMhUW6maXHuJG9k\WGwIIP0doFqdiB6OUmgbY5n\WO2ZXSgbY4hSW[{aXPhckBoemWnbjDtc45s\XliVnXyc{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgO{Bl[Xm|IHL5JG1VWy:STWOgcYV1cG:mLDDFR|kxKD1iMkGg{txONg>? M2PLO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OECwOlI3Lz5{NEiwNFYzPjxxYU6=
Vero NFnWZ2hEgXSxdH;4bYNqfHliYYPzZZk> NH\zfXc4OiCqcoO= NV22bFE{S3m2b4TvfIlkcXS7IHHnZYlve3RiYX\ybYNidiCpcnXlckBud26tZYmgWoVzdyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhVVSVIHHzd4F6NCCLQ{WwJF0hOjFizszNMi=> MlTXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5Mke1N|goRjJ|N{K3OVM5RC:jPh?=
HepG2 NH[3c4ZEgXSxdH;4bYNqfHliYYPzZZk> MmLTOFghcHK| MVzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgcIFkfGG2ZTDk[Yh6\HKxZ3XuZZNmKGG|c3H5MEBIUTVyIE2gNlIvOTZizszNMi=> MmO3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6OEK4N|EoRjJzOEiyPFMyRC:jPh?=
KB M{fOd2N6fG:2b4jpZ4l1gSCjc4PhfS=> Mn:1O|IhcHK| NUjuV2FHS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hU0JiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VWyCjc4PhfUwhUUN3MDC9JFIzNjVizszNMi=> NVK2U5lbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm4O|kyPTBpPkG5PFc6OTVyPD;hQi=>
MDA-MB-231 MYXDfZRwfG:6aXPpeJkh[XO|YYm= NGXSZnA1QCCqcoO= NHfv[GhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCyNk42OiEQvF2u MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQThyNEm3PUc,OTl6MES5O|k9N2F-
MDA-MB-231 NFXVW2pCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NVLPWYlsPDhiaILz NHzLNnNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIIC1N{wheFKEIH31eIFvfCCjbnSg[ZN1em:pZX6gdoVk\XC2b4Kg[IVncWOrZX70JG1FSS2PQj2yN|Eh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygS2k2OCB;IEKyMlUzKM7:TT6= MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODV4MUeyNEc,OjB3NkG3NlA9N2F-
MDA-MB-231 NXXkR2RCS3m2b4TvfIlkcXS7IHHzd4F6 MXG0PEBpenN? M1nHRmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFIzNjV{IN88UU4> MlzhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3OE[3NVYoRjJ6NUi2O|E3RC:jPh?=
CEM M4LWdGN6fG:2b4jpZ4l1gSCjc4PhfS=> MlLCR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR2VOKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gZ4VtdCCycn;sbYZmemG2aX;uJIJ6KEOxdXz0[ZIh[2:3boTldkBidmGueYPpd{whUUN3MDC9JFI{KM7:TT6= NXniPFc1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xNVQ5OTFpPkK2NVE1QDFzPD;hQi=>
CE81T NELpcWRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVG0PEBpenN? NELwUoFIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBETThzVDDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6KGmwIIDy[ZNmdmOnIH;mJFExLSCIQmOgd5VxeGynbXXueIVlKESPRV2gcYVlcXWvLDDHTVUxKD1iMkOuOEDPxE1w NIS3dZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUe0PFc5Pid-MUm3OFg4QDZ:L3G+
MCF7 MXvDfZRwfG:6aXPpeJkh[XO|YYm= M2rwcFczKGi{cx?= M3fvWmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxiboXtZoVzKGmwY4XiZZRm\CCob4KgO|IhcHK|LDDJR|UxKD1iMkOuOFMh|ryPLh?= NHn3V4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGzOVQ4OSd-Mk[xN|U1PzF:L3G+
HepG2 MV\DfZRwfG:6aXPpeJkh[XO|YYm= M{fIVlczKGi{cx?= MmfyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNiaX70doFk\WyudXzhdkBCXFBibHX2[Ywh[W[2ZYKgO|IhcHK|IHL5JGNmdGy2aYTldk1IdG9ibIXtbY5me2OnboSgZZN{[XluIFXDOVAhRSB{NTFOwG0v MlfCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7MUC0OlYoRjJzOUGwOFY3RC:jPh?=
HepG2 M17kcmN6fG:2b4jpZ4l1gSCjc4PhfS=> MVe3NkBpenN? MknVR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxiboXtZoVzKGmwY4XiZZRm\CCob4KgO|IhcHK|LDDJR|UxKD1iMkWg{txONg>? NHzqW2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGzOVQ4OSd-Mk[xN|U1PzF:L3G+
BxPC3 MVLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NFPaWW04OiCqcoO= MV3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEK6UFOzJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCVUlKgcYV1cG:mLDDJR|UxKD1iMkWg{txONg>? NGnZfFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[5PVE2Pyd-MkW2PVkyPTd:L3G+
MDA-MB-468 MXnDfZRwfG:6aXPpeJkh[XO|YYm= MVG0PEBpenN? Ml;WR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUS2PEBk\WyuczDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMkiuOVgh|ryPLh?= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQThyNEm3PUc,OTl6MES5O|k9N2F-
MDA-MB-468 MUTDfZRwfG:6aXPpeJkh[XO|YYm= MlHaOFghcHK| Mnm0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUS2PEBk\WyuczDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMkiuOVgh|ryPLh?= Ml;KQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzME[2OlgoRjJyMUC2OlY5RC:jPh?=
MDA-MB-468 NXTuVnZPS3m2b4TvfIlkcXS7IHHzd4F6 MYC0PEBpenN? MmnqR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUS2PEBk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gNlgvPThizszNMi=> MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV6NkexOkc,Ojh3OE[3NVY9N2F-
K562 MkX2R5l1d3SxeHnjbZR6KGG|c3H5 M33pZmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkmuNFMh|ryPLh?= NWHTNlBYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1OlIzODJpPkG4OVYzOjB{PD;hQi=>
HeLa MoPRRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NGWwVHY4OiCqcoO= NHKwWZJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjlUIEh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IGPSRkBie3OjeTygTWM2OCB;IEK5Mlk3KM7:TT6= NHu2O3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[wNlgzPyd-Mk[2NFI5Ojd:L3G+
HepG2 M4fGO2N6fG:2b4jpZ4l1gSCjc4PhfS=> MUm3NkBpenN? Mn[1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFMxKM7:TT6= NUHWcmZRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm0PFI1PzZpPkG5OFgzPDd4PD;hQi=>
HepG2 MoHkR5l1d3SxeHnjbZR6KGG|c3H5 NYXRT3pvPzJiaILz M{LkbGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{OCEQvF2u NUDtfW5tRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5NlYyPzNpPkG5PVI3OTd|PD;hQi=>
HepG2 MWPDfZRwfG:6aXPpeJkh[XO|YYm= M3TMcmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOwJO69VS5? NIT0cVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{m4NVQ3Oid-MUe5PFE1PjJ:L3G+
HepG2 MnGzR5l1d3SxeHnjbZR6KGG|c3H5 MoDDO|IhcHK| NFLVNJhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCFQ{WwJF0hOzBizszNMi=> M{nYO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{SxNVMyLz5{MUe0NVE{OTxxYU6=
HepG2 M1TCOGN6fG:2b4jpZ4l1gSCjc4PhfS=> M{nuS|czKGi{cx?= NWXIZ5RDS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiQ1O1NEA:KDNyIN88UU4> M{DCPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEi5OVU6Lz5{Mki4PVU2QTxxYU6=
HepG2 NWLWZXZES3m2b4TvfIlkcXS7IHHzd4F6 MVm3NkBpenN? MV3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBESzVyIE2gN|Ah|ryPLh?= Mmq2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NE[yNVYoRjJ2OUS2NlE3RC:jPh?=
SH-SY5Y MWPDfZRwfG:6aXPpeJkh[XO|YYm= Mk\vO|IhcHK| M4jqcGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNJNVO\NWmgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiQ1O1NEA:KDNyIN88UU4> M1zKW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUW5NVk5Lz5{OUW1PVE6QDxxYU6=
HepG2 MkLIR5l1d3SxeHnjbZR6KGG|c3H5 M2HZeFczKGi{cx?= Mlr0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhS0N3MDC9JFMxKM7:TT6= NUD4[|h2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4OVg2PDNpPkK0PFU5PTR|PD;hQi=>
HepG2 MVHDfZRwfG:6aXPpeJkh[XO|YYm= M3jSdFczKGi{cx?= M{nRUGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KG2nYYP1doVlKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEOFNUCgQUA{OCEQvF2u Mn7aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzNUW0OlMoRjJ5MUW1OFY{RC:jPh?=
HepG2 NYP6cpdYS3m2b4TvfIlkcXS7IHHzd4F6 MmrBO|IhcHK| MkHnR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhS0N3MDC9JFMxKM7:TT6= NWrBNoVGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3PVE3PzVpPkK1O|kyPjd3PD;hQi=>
HepG2 MmDFR5l1d3SxeHnjbZR6KGG|c3H5 Ml\nO|IhcHK| NHvwUFNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFRiYYPzZZktKEOFNUCgQUA{OCEQvF2u M{\mfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MkiyNlY4Lz5{NUK4NlI3PzxxYU6=
HepG2 MlnsR5l1d3SxeHnjbZR6KGG|c3H5 NFTZPWc4OiCqcoO= MYfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBESzVyIE2gN|Ah|ryPLh?= M3z6eFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEWyNVMzLz5{MUi1NlE{OjxxYU6=
HepG2 MXvDfZRwfG:6aXPpeJkh[XO|YYm= M2LXeFczKGi{cx?= MU\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBESzVyIE2gN|Ah|ryPLh?= M3jQblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NkC4Olc2Lz5{Mk[wPFY4PTxxYU6=
HepG2 MkTnR5l1d3SxeHnjbZR6KGG|c3H5 NXPXNo5ZPzJiaILz MUPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiQ1O1NEA:KDNyIN88UU4> NY\mUWdTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2OVQ{QTVpPkK3OlU1Ozl3PD;hQi=>
KB M1XvVGN6fG:2b4jpZ4l1gSCjc4PhfS=> M4LnNmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGtDKGOnbHzzJIJ6KFOUQjDhd5NigSxiRVS1NEA:KDNyLkig{txONg>? M4HMe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NU[yPFMzLz5zNkW2Nlg{OjxxYU6=
HepG2 NW\mVGJ2S3m2b4TvfIlkcXS7IHHzd4F6 NIr4[mUzPCCqcoO= MmG1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgNlQhcHK|IHL5JI5mfXS{YXygdoVlKHWydHHr[UBie3OjeTygWGM2OCB;IEOxJO69VS5? MonHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzNEW4NVYoRjJ|MUS1PFE3RC:jPh?=
K562 M33X[GN6fG:2b4jpZ4l1gSCjc4PhfS=> M1HteVczKGi{cx?= NVjiSlBmS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkA4OiCqcoOgZpkh\myxdzDjfZRwdWW2comsJGlEPTBiPTCzNkDPxE1w NH7xSFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUS4NlQ4Pid-MUm0PFI1PzZ:L3G+
K562 NY\ybVh3S3m2b4TvfIlkcXS7IHHzd4F6 M2njNlczKGi{cx?= MXvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDmcI94KGO7dH;t[ZRzgSxiSVO1NEA:KDN{IN88UU4> NUnyT2JjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5NlYyPzNpPkG5PVI3OTd|PD;hQi=>
FM3A NUTQR4ZbSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NGjBUopCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JG1wfXOnIH3hcY1ienlidIXtc5IhTk1|QTDj[YxteyxiRVO1NEA:KDN{IN88UU4> NGXMNXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEm2Olc1Pid-MUC5OlY4PDZ:L3G+
FM3A MonHR5l1d3SxeHnjbZR6KGG|c3H5 Mn:zTY4hfmm2cn:gZ5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgcYFudWG{eTDGUVNCKGOnbHzzMEBGSzVyIE2gN|Ih|ryPLh?= M1n6VlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{MEO2N|Y2Lz5zMkCzOlM3PTxxYU6=
FM3A M3LsS2N6fG:2b4jpZ4l1gSCjc4PhfS=> NVzJWGR1S3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhdWGvbXHyfUB1fW2xcjDGUVNCKGOnbHzzJJJmeHKnc3XueIlv\yCjIH3v[IVtKG:oIHjvd5QtKEWFNUCgQUA{OiEQvF2u MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTh3NUm3PEc,OTF6NUW5O|g9N2F-
FM3A M4XNbGN6fG:2b4jpZ4l1gSCjc4PhfS=> MoTJR5l1d3SxeHnjbZR6KGGpYXnud5QhTk1|QTDtc5V{\SCvYX3tZZJ6KGOnbHzzMEBGSzVyIE2gN|Ih|ryPLh?= M1nPeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF|Nke4OFE{Lz5zM{[3PFQyOzxxYU6=
FM3A MWnDfZRwfG:6aXPpeJkh[XO|YYm= NYjQUXFZPDhiaILz Ml71R5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgSm0{SSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJIlv[3KnYYPlJIlvKGOnbHyg[IVve2m2eTDh[pRmeiB2ODDodpMtKEWFNUCgQUA{OiEQvF2u NHnKV|A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOES3PVkzPid-MUi0O|k6OjZ:L3G+
FM3A M2jMZWN6fG:2b4jpZ4l1gSCjc4PhfS=> MYHDc41xd3WwZDD3ZZMhfGW|dHXkJIZweiCleYTveI95cWOrdImgZYdicW6|dDDGUVNCKG2xdYPlJI1idW2jcomgZ4VtdHNwIDygSWM2OCB;IEOyJO69VS5? NYD3b5pORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC0OFc6PjFpPkGwOFQ4QTZzPD;hQi=>
LNCAP MWDDfZRwfG:6aXPpeJkh[XO|YYm= NFzSOmw4OiCqcoO= M2fYO2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGxPS0GSIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuIH71cYJmeiCrbnP1ZoF1\WRiZn;yJFczKGi{czygTWM2OCB;IEOyMlg4KM7:TT6= M2PFR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUO1OFcyLz5{NkGzOVQ4OTxxYU6=
HCT116 M3vGVWN6fG:2b4jpZ4l1gSCjc4PhfS=> NFvPcnk4OiCqcoO= NH[xZ5NEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzMU[gZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KFeVVEGgZZN{[XluIFnDOVAhRSB|Mz63JO69VS5? MmPUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ|OUi1N|EoRjF{M{m4OVMyRC:jPh?=
KB NFHHeWFEgXSxdH;4bYNqfHliYYPzZZk> M2f1NlczKGi{cx?= MY\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLRkBk\WyuczDh[pRmeiB5MjDodpMh[nliU2LCJIF{e2G7LDDFSFUxKD1iM{OuO{DPxE1w NGrUSFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi97OUG3Nlg{Lz57OUG3Nlg{RC:jPh?=
KB NV7Ub4hrS3m2b4TvfIlkcXS7IHHzd4F6 MkLFO|IhcHK| MYLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLRkBk\WyuczDh[pRmeiB5MjDodpMh[nliQXzhcYFzKGKudXWgZZN{[XluIFnDOVAhRSB|NDFOwG0v NW\1c4p{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFA4OjRpPkK0PVAxPzJ2PD;hQi=>
CHO NXTHU2hbS3m2b4TvfIlkcXS7IHHzd4F6 NEfyVGZEgXSxdH;4bYNqfHliYXfhbY5{fCCFSF:gZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|UvQCEQvF2u MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjh|MkKyNkc,OjZ6M{KyNlI9N2F-
KB MlLoR5l1d3SxeHnjbZR6KGG|c3H5 NUTYc2pbS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hU0JiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25uIFnDOVAhRSB|NT65OUDPxE1w NEP4dWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUewOVIzOCd-MkG3NFUzOjB:L3G+
MCF7 M3\CTGN6fG:2b4jpZ4l1gSCjc4PhfS=> NHzIZ5U1QCCqcoO= M1;NUGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFM3NjFizszNMi=> MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTh7MkW1OEc,OTl6OUK1OVQ9N2F-
MDA-MB-231 MmTRRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NHSxeGg4OiCqcoO= NYnJfGQzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCVUlKgZZN{[XluIFnDOVAhRSB|Nj61N{DPxE1w NGHQdng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[wNlgzPyd-Mk[2NFI5Ojd:L3G+
NFF M{HnWWN6fG:2b4jpZ4l1gSCjc4PhfS=> NXfMSFNKOyCmYYnz MnLWR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUmZHKGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHHzd4F6NCCLQ{WwJF0hOzdwMzFOwG0v MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzFzN{G3NEc,OjNzMUexO|A9N2F-
MCF7 NHLDXXlEgXSxdH;4bYNqfHliYYPzZZk> MWm0PEBpenN? NVLITHBiS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCJSUWwJF0hOzhwNESg{txONg>? MkHZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl6MES5O|koRjF7OEC0PVc6RC:jPh?=
MCF7 MnzyR5l1d3SxeHnjbZR6KGG|c3H5 MU[0PEBpenN? MYTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCzPE41PCEQvF2u NH3mVVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEGwOlY3QCd-MkCxNFY3Pjh:L3G+
p53+/- MCF7 M2jFRmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 Mn\4OFghcHK| M1\mWmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5icEWzL{8uKE2FRkegZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiR1m1NEA:KDN6LkS0JO69VS5? MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODV4MUeyNEc,OjB3NkG3NlA9N2F-
MCF7 MVXDfZRwfG:6aXPpeJkh[XO|YYm= NEXBZmY1QCCqcoO= NWj3OYEyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDJR|UxKD1iM{iuOFQh|ryPLh?= NGHxVoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW4OlcyPid-Mki1PFY4OTZ:L3G+
Caco2 NF\sNo5CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NHHyPFkzKGSjeYO= NVG0b4UzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDDZYNwOiClZXzsd{Bi\nSncjCyJIRigXNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiR1m1NEA:KDN6Lk[3JO69VS5? MnzsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzOESwO|YoRjJ2MUi0NFc3RC:jPh?=
THP1 MnvVR5l1d3SxeHnjbZR6KGG|c3H5 NVvs[I9OS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXEiSMTDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0NEDPxE1w NE[wPFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{m4NVQ3Oid-MUe5PFE1PjJ:L3G+
THP1 MkPUR5l1d3SxeHnjbZR6KGG|c3H5 NX;0dXVsPzJiaILz M2qxUGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHRJWDFiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JJBzd3CrZHn1cUBqd2SrZHWgd5RicW6rbnetZoF{\WRiZnzve{BkgXSxbXX0dpktKEmFNUCgQUA1OCEQvF2u NGDxUGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUe0PFc5OSd-MUm3OFg4QDF:L3G+
THP1 MY\DfZRwfG:6aXPpeJkh[XO|YYm= NFvEfFU4OiCqcoO= MWrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDUTHAyKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDBcIFu[XJiYnz1[UBie3OjeTygTWM2OCB;IESwJO69VS5? MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTlzNEe0O{c,OTl7MUS3OFc9N2F-
THP1 M2HNO2N6fG:2b4jpZ4l1gSCjc4PhfS=> NUfL[HVCPzJiaILz Mkj5R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWGhROSClZXzsd{B2e2mwZzDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pIHHmeIVzKDd{IHjyd{BjgSCobH;3JIN6fG:vZYTyfUwhUUN3MDC9JFQxKM7:TT6= MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODZ|OEi1OEc,OjB4M{i4OVQ9N2F-
HEK293 NUTQblBWS3m2b4TvfIlkcXS7IHHzd4F6 MlPiO|IhcHK| MULDfZRwfG:6aXPpeJkh[WejaX7zeEBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhSWyjbXHyJIJtfWViYYPzZZktKEmFNUCgQUA1OCEQvF2u NYDLR2pQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3O|Q1OjdpPkK4O|c1PDJ5PD;hQi=>
NCH-89 M4XUNGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MkXhOFghcHK| MnPmRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiClYYLteZN1cW6nLYLld4l{fGGwdDDOR2guQDliY3XscJMh[XO|ZYPz[YQh[XNiQoLkWUBqdmOxcoDvdoF1cW:wIHHmeIVzKDR6IHjyd{whUUN3MDC9JFQyNjJizszNMi=> NI\jUnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEOyPVc{Oyd-MkCzNlk4OzN:L3G+
HepG2 MVPDfZRwfG:6aXPpeJkh[XO|YYm= M2PoXlQ5KGi{cx?= MUnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxiZ4Lve5RpKGGodHXyJFQ5KGi{czDifUBNTEhiYYPzZZktKEeLNUCgQUA1Oy5yOTFOwG0v NWPU[IFsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PFQ1OjJpPkK1Olg1PDJ{PD;hQi=>
L6 M{mzPHRwgGmlaYT5JIF{e2G7 MWXUc5hq[2m2eTDh[4FqdnO2IILheEBNPiClZXzsd{whUUN3MDC9JFQ{NjFizszNMi=> M3\xSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7N{ixPVQ5Lz5zOUe4NVk1QDxxYU6=
KB MYrDfZRwfG:6aXPpeJkh[XO|YYm= MlHBO|IhcHK| M33LN2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGtDKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJiYnz1[UBie3OjeTygR2M2OCB;IES0JO69VS5? MmjYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjByMUS4OVcoRjJyMEG0PFU4RC:jPh?=
MKN28 MYLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? Mn\lNkBl[Xm| MorkRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPS16yPEBk\WyuczDh[pRmeiB{IHThfZMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhT0l3MDC9JFQ1NjR2IN88UU4> M4\6eVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUi0NFc3Lz5{NEG4OFA4PjxxYU6=
NFF NV\6cZpKS3m2b4TvfIlkcXS7IHHzd4F6 MVTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDOSmYh[2WubIOsJGlEPTBiPTC0Ok43ODhizszNMi=> NF;X[2I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEK0OVQxOid-M{CyOFU1ODJ:L3G+
J774 MlHsR5l1d3SxeHnjbZR6KGG|c3H5 M33KNFczKGi{cx?= M1\PXWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGo4PzRiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JGNmdGyWaYTldk06PiCjcYXlc5V{KG:wZTDzc4x2fGmxbjDj[YxtKHC{b3zp[oVz[XSrb36gZZN{[XluIFXDOVAhRSB2Nz6yJO69VS5? NGLPfHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUKxOVI4QSd-MkmyNVUzPzl:L3G+
HEK293 NWf6eJBlS3m2b4TvfIlkcXS7IHHzd4F6 MWW3NkBpenN? NEXve|FEgXSxdH;4bYNqfHliYXfhbY5{fCCKRVuyPVMh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IFHsZY1ieiCEbIXlJIF{e2G7LDDJR|UxKD1iNEig{txONg>? MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTF7MEi1O{c,OjFzOUC4OVc9N2F-
MRC5 MVLDfZRwfG:6aXPpeJkh[XO|YYm= NHLITXJEgXSxdH;4bYNqfHliYXfhbY5{fCCPUlO1JINmdGy| NFqw[FI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G2OlcyQCd-MUexOlY4OTh:L3G+
HeLa MYXGeY5kfGmxbjDhd5NigQ>? NUTXNWNOOTBidV2= NIjuRXUyKGi{ NYO2RlNqW3SrbYXsZZRqd25ib3[gdoVi[3SrdnWgc5h6\2WwIIPw[YNq\XNiaX6gbJVu[W5iSHXMZUBk\WyuczDheEAyOCC3TTDpckBxemW|ZX7j[UBw\iBzMDD1UUBEfUOuMjDh[pRmeiBzIHjyJIJ6KGSraInkdo9mfGirZHn1cUBlgWViYnHz[YQh\my3b4Lld4NmdmOnIHHzd4F6 MnznQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5NEi3PFYoRjF7N{S4O|g3RC:jPh?=
A673 MVzxTHRUKGG|c3H5 NWHaTIZieUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IFG2O|Mh[2WubIO= Mmn6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
DAOY M3XXU5FJXFNiYYPzZZk> MUXxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhTEGRWTDj[Yxtew>? NEnmWJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
Saos-2 M1e2UZFJXFNiYYPzZZk> Mnn3dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKFOjb4OtNkBk\Wyucx?= MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
RD M3PKTZFJXFNiYYPzZZk> NFfRblhyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiUlSgZ4VtdHN? MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
BT-37 NWfHSY44eUiWUzDhd5NigQ>? MnfGdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKEKWLUO3JINmdGy| NVewS3lMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
BT-12 NFXsSFlyUFSVIHHzd4F6 Mk\sdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKEKWLUGyJINmdGy| MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
MG 63 (6-TG R) NW[5c5VIeUiWUzDhd5NigQ>? MoPldWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKE2JIE[zJEg3NVSJIGKpJINmdGy| MmX1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
NB1643 NUTxdGRQeUiWUzDhd5NigQ>? MVXxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVkJzNkSzJINmdGy| MmfWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
OHS-50 M2XuOJFJXFNiYYPzZZk> M1vPUZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCRSGOtOVAh[2WubIO= NYDXcVRkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
SK-N-MC NVTIOGRqeUiWUzDhd5NigQ>? MnLldWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKFONLV6tUWMh[2WubIO= MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
LAN-5 NInQVIVyUFSVIHHzd4F6 NEHyNJByUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiTFHOMVUh[2WubIO= M3TBfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
HEK293 MVjBeZRweGijZ4mgZZN{[Xl? MX2xNEB2VQ>? M1jKOlghcHK| M4nm[2lv\HWldHnvckBw\iCjdYTvdIhi\3liaX6gTGVMOjl|IHPlcIx{KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJJA3OiCuZY\lcEBifCBzMDD1UUBi\nSncjC4JIhzeyCkeTDpcY12dm:kbH;0JIFv[Wy7c3nz M1jwTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NEixOVM3Lz5{OES4NVU{PjxxYU6=
HEK293 NV3IelZ5SXW2b4DoZYd6KGG|c3H5 MmLFNVAhfU1? M2qx[VghcHK| NGjMeHNKdmS3Y4Tpc44hd2ZiYYX0c5Bp[We7IHnuJGhGUzJ7MzDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBNSzNvMjDs[ZZmdCCjdDCxNEB2VSCjZoTldkA5KGi{czDifUBqdW23bn;icI91KGGwYXz5d4l{ M1G3NFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NEixOVM3Lz5{OES4NVU{PjxxYU6=
LNCAP NXfSdo1xTnWwY4Tpc44h[XO|YYm= NY\wNmpzWmWmdXP0bY9vKGmwIFfGVEBmgHC{ZYPzbY9vKGmwIHj1cYFvKEyQQ1HQJINmdGy|IITyZY5{\mWldHXkJJdqfGhicHzhd41q\HNiY3:t[ZhxemW|c3nu[{BITlBiYX7kJJNpWk6DczDh[4FqdnO2IGLFWk1GWkKkZYThJIZwdGyxd3XkJIJ6KGOxbYDveY5lKHS{ZXH0cYVvfCB{NDDodpMheG:|dD30doFve2[nY4Tpc44h[W6mIH3lZZN2emWmIES4JIhzeyCyb4P0JIRwe2V? MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF|NUS3NUc,OjZzM{W0O|E9N2F-
SKBR3 M2nNbWZ2dmO2aX;uJIF{e2G7 Mn7jVoVlfWO2aX;uJIlvKEeIUDDlfJBz\XO|aX;uJIlvKGi3bXHuJHNMSlJ|IHPlcIx{KHS{YX7z[oVkfGWmIIfpeIgheGyjc33p[JMh[29vZYjwdoV{e2mwZzDHSnAh[W6mIIPoVm5CeyCjZ3HpcpN1KFKHVj3FVmJj\XSjIH\vcIxwf2WmIHL5JINwdXCxdX7kJJRz\WG2bXXueEAzPCCqcoOgdI9{fC22cnHud4Zm[3Srb36gZY5lKG2nYYP1doVlKDR6IHjyd{Bxd3O2IHTvd4U> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF|NUS3NUc,OjZzM{W0O|E9N2F-
HepG2 M4[3[WZ2dmO2aX;uJIF{e2G7 MmHCVoVlfWO2aX;uJIlvKEeIUDDlfJBz\XO|aX;uJIlvKGi3bXHuJGhmeEd{IHPlcIx{KHS{YX7z[oVkfGWmIIfpeIgheGyjc33p[JMh[29vZYjwdoV{e2mwZzDHSnAh[W6mIIPoVm5CeyCjZ3HpcpN1KFKHVj3FVmJj\XSjIH\vcIxwf2WmIHL5JINwdXCxdX7kJJRz\WG2bXXueEAzPCCqcoOgdI9{fC22cnHud4Zm[3Srb36gZY5lKG2nYYP1doVlKDR6IHjyd{Bxd3O2IHTvd4U> MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF|NUS3NUc,OjZzM{W0O|E9N2F-
H460 NX\FcYF4SXCxcITvd4l{KGG|c3H5 M2jld|I2KHSxIEe1JJVO NFLyWWYzPCCqcoO= Ml;sTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCKNE[wJINmdGy|IHH0JFI2KHSxIEe1JJVOKGGodHXyJFI1KGi{czDifUBidm6neHnuMXYhe3SjaX7pcocu[mG|ZXSg[oxwfyCleYTvcYV1enl? MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ7OUG1O{c,OjV4OUmxOVc9N2F-
HepG2 NHjYNm5HfW6ldHnvckBie3OjeR?= NU\IZ49uPTBidV2= Mlf6OkBpenN? MXnS[YR2[3Srb36gbY4hdHm|b4PvcYFtKGGlaXTp[olk[XSrb36gbY4hcHWvYX6gTIVxTzJiY3XscJMh[XRiNUCgeW0h[W[2ZYKgOkBpenNiYomgSGFRUS:ueYPvJJRz[WOtZYKgdoVlNWSxdXLs[UB{fGGrbnnu[{Bj[XOnZDDjc45nd2OjbDDtbYNzd3Olb4DpZ{BidmGueYPpd{Bz\WyjdHn2[UB1dyClb370do9t MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF7N{OyNEc,OjhzOUezNlA9N2F-

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

アッセイ
Methods Test Index PMID
Western blot
ZEBRA / p-S824 KAP1 ; 

PubMed: 28249048     


HH514-16 BL cells were treated with chloroquine and harvested at different times post-treatment for immunoblotting with antibodies as indicated. 

p62 / LC3 ; 

PubMed: 26677873     


Antiautophagic activity of Lys01. Panc 10.05 cells were treated for 24 h with the indicated doses of chloroquine or Lys01 and were probed by Western blot.

28249048 26677873
Immunofluorescence
p-S824 KAP1 / ZEBRA ; 

PubMed: 28249048     


HH514-16 BL cells were treated with chloroquine (CQ) or chloroquine plus KU-55933 (CQ+KU) and harvested at 24 hours followed by staining with anti-phospho KAP1 (S824) plus anti-ZEBRA antibodies and visualized at 1000X magnification.

CD1d-β2m / LAMP1 ; 

PubMed: 20368272     


HEK293-CD1d WT cells were treated overnight with 20 μM of chloroquine (or vehicle). The cells were then fixed, permeabilized and stained with the anti-CD1d-β2m mAb (red), anti-LAMP-1 (green) and Hoechst (blue). The stained cells were then analyzed by confocal microscopy. 

SQSTM1 / MAP1LC3B ; 

PubMed: 29872540     


Immunofluorescent images of astrocytoma SNB-19 cells treated with DMSO, emetine or chloroquine for 24 h, then stained with SQSTM1 protein (green), MAP1LC3B protein (red) and nuclei (blue). 

28249048 20368272 29872540
Growth inhibition assay
Cell viability ; 

PubMed: 25521075     


A549 cells were treated with serial concentrations of chloroquine for 72 h, and Huh7 cells were treated with the same concentrations for 48 h. Tumour cell viability was determined by cell viability assay. Data represent means from at least three independent experiments ± SD. 

25521075

お薦めの試験操作(参考用のみ)

溶解度 (25°C)

体外 Water 100 mg/mL (193.85 mM)
DMSO Insoluble
Ethanol Insoluble

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 515.86
化学式

C18H26ClN3.2H3O4P

CAS No. 50-63-5
Storage powder
in solvent
別名 N/A
Smiles CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O

投与溶媒組成計算器(クリア溶液)

ステップ1:実験データを入力してください。(実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します)
投与量 mg/kg 動物平均体重 g 投与体積(動物毎) ul 動物数
ステップ2:投与溶媒の組成を入力してください。(ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください)
% DMSO % % Tween 80 % ddH2O
計算リセット

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (mg) = 濃度 (mM) x 体積 (mL) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04443270 Not yet recruiting Drug: Chloroquine phosphate COVID-19 CMN 20 de Noviembre July 27 2020 Phase 1
NCT04462367 Recruiting -- COVID19|Coronavirus Infection|Pregnancy Disease|Severe Acute Respiratory Syndrome Instituto Materno Infantil Prof. Fernando Figueira July 1 2020 --
NCT04340544 Terminated Drug: Hydroxychloroquine|Drug: Placebo COVID-19 University Hospital Tuebingen|Robert Bosch Medical Center|Universitätsklinikum Hamburg-Eppendorf|Bernhard Nocht Institute for Tropical Medicine April 22 2020 Phase 2
NCT02378532 Completed Drug: Chloroquine|Radiation: Radiotherapy|Drug: Temozolomide Glioblastoma Multiforme Maastricht Radiation Oncology August 2016 Phase 1

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

ATM/ATRシグナル伝達経路

相関ATM/ATR製品

Tags: Chloroquine diphosphateを買う | Chloroquine diphosphate ic50 | Chloroquine diphosphate供給者 | Chloroquine diphosphateを購入する | Chloroquine diphosphate費用 | Chloroquine diphosphate生産者 | オーダーChloroquine diphosphate | Chloroquine diphosphate化学構造 | Chloroquine diphosphate分子量 | Chloroquine diphosphate代理店
×
細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID