Chloroquine diphosphate

製品コードS4157 バッチS415704

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₈H₂₆ClN₃.2H₃O₄P
	分子量	515.86	CAS No.	50-63-5
Solubility (25°C)*	体外	Water	100 mg/mL (193.85 mM)
		DMSO	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Chloroquine diphosphateは、4-アミノキノリン系の抗マラリア薬および抗リウマチ薬であり、ATM活性化因子としても作用します。クロロキンは、Toll様受容体（TLRs）の阻害剤でもあります。
in vitro	Chloroquine is a chemotherapeutic agent for the clinical treatment of malaria. Chloroquine is able to bind to DNA, and inhibit DNA replication and RNA synthesis which in turn results in cell death. The effect of Chloroquine may also be related to the formation of a toxic heme-Chloroquine complex. Chloroquine inhibits trophozoite hemoglobin degradation through increasing vacuolar pH and inhibiting the activity of vacuolar phospholipase, vacuolar proteases, and heme polymerase. Chloroquine possesses definite antirheumatic properties. Chloroquine has immuno-modulatory effects, suppressing the production/release of tumour necrosis factor and interleukin 6. Moreover, Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best-studied effects are those against HIV replication. Chloroquine can accumulate inside the macrophage phagolysosome by ion trapping where it exerts potent antifungal activity against Histoplasma capsulatum and Cryptococcus neoformans by distinct mechanisms. Chloroquine inhibits growth of H. capsulatum by pH-dependent iron deprivation, whereas it is directly toxic to C. neoformans.
in vivo	Chloroquine has tumor‑inhibitory and tumor‑promoting effects in triple‑negative breast cancer.

製品説明

Chloroquine diphosphateは、4-アミノキノリン系の抗マラリア薬および抗リウマチ薬であり、ATM活性化因子としても作用します。クロロキンは、Toll様受容体（TLRs）の阻害剤でもあります。

in vitro

Chloroquine is a chemotherapeutic agent for the clinical treatment of malaria. Chloroquine is able to bind to DNA, and inhibit DNA replication and RNA synthesis which in turn results in cell death. The effect of Chloroquine may also be related to the formation of a toxic heme-Chloroquine complex. Chloroquine inhibits trophozoite hemoglobin degradation through increasing vacuolar pH and inhibiting the activity of vacuolar phospholipase, vacuolar proteases, and heme polymerase.

Chloroquine possesses definite antirheumatic properties. Chloroquine has immuno-modulatory effects, suppressing the production/release of tumour necrosis factor and interleukin 6. Moreover, Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best-studied effects are those against HIV replication.

Chloroquine can accumulate inside the macrophage phagolysosome by ion trapping where it exerts potent antifungal activity against Histoplasma capsulatum and Cryptococcus neoformans by distinct mechanisms. Chloroquine inhibits growth of H. capsulatum by pH-dependent iron deprivation, whereas it is directly toxic to C. neoformans.

in vivo

Chloroquine has tumor‑inhibitory and tumor‑promoting effects in triple‑negative breast cancer.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Monocytes
	濃度	20 μM
	反応時間	1 h
	実験の流れ	Cells were treated with indicated concentration of drug for 1 h.
動物実験	動物モデル	Athymic nude/nu mice
	投薬量	80 mg/kg
	投与方法	i.p.

参考

https://pubmed.ncbi.nlm.nih.gov/8361993/
https://pubmed.ncbi.nlm.nih.gov/14592603/
https://pubmed.ncbi.nlm.nih.gov/10972492/

https://pubmed.ncbi.nlm.nih.gov/18305095/
https://pubmed.ncbi.nlm.nih.gov/25385822/
https://pubmed.ncbi.nlm.nih.gov/24273604/

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カスタマーフィードバック

: , , Leukemia, 2017, 31(5):1123-1135

: , , Int J Mol Med, 2017, 40(1):182-192

: Data from [Data independently produced by , , Cancer Lett, 2018, 436:129-138]

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長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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