Anti-infection

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S5001 Tofacitinib (CP-690550) Citrate <1 mg/mL 100 mg/mL '<1 mg/mL
S4157 Chloroquine diphosphate 100 mg/mL <1 mg/mL <1 mg/mL
S5967 Berberine chloride hydrate 39 mg/mL 78 mg/mL '<1 mg/mL
S4945 Ethacridine lactate 69 mg/mL 69 mg/mL ''20 mg/mL
S4417 Ceftaroline Fosamil <1 mg/mL 73 mg/mL ''''<1 mg/mL
S3226 Dehydroabietic acid -1 mg/mL 100 mg/mL -1 mg/mL
S3308 Caftaric acid -1 mg/mL 100 mg/mL -1 mg/mL
S3220 Trigonelline -1 mg/mL 50 mg/mL -1 mg/mL
S3261 Myrislignan -1 mg/mL 100 mg/mL -1 mg/mL
S2572 Streptomycin sulfate 89 mg/mL <1 mg/mL <1 mg/mL
S8279 Shikonin (C.I. 75535) <1 mg/mL 57 mg/mL 23 mg/mL
S1553 Delafloxacin (ABT-492) <1 mg/mL 88 mg/mL '<1 mg/mL
S4946 2,3-Dihydroxybenzoic acid -1 mg/mL 30 mg/mL -1 mg/mL
S8068 Chaetocin <1 mg/mL 100 mg/mL <1 mg/mL
S4430 Hydroxychloroquine Sulfate (NSC 4375) 67 mg/mL <1 mg/mL ''<1 mg/mL
S4303 9-Aminoacridine <1 mg/mL 38 mg/mL '38 mg/mL
S5927 Proguanil <1 mg/mL 51 mg/mL '51 mg/mL
S6771 MAC-545496 ˂1 mg/mL 84 mg/mL ˂1 mg/mL
S3711 Carbasalate Calcium 91 mg/mL 11 mg/mL <1 mg/mL
S9341 3,4-Dimethoxycinnamic acid -1 mg/mL 42 mg/mL -1 mg/mL
S4515 Ademetionine disulfate tosylate 79 mg/mL 79 mg/mL <1 mg/mL
S2430 Azodicarbonamide <1 mg/mL 23 mg/mL <1 mg/mL
S6802 Etosalamide 6 mg/mL 42 mg/mL '42 mg/mL
S7867 Oleuropein 100 mg/mL 100 mg/mL 100 mg/mL
S4549 Antimonyl potassium tartrate trihydrate 100 mg/mL <1 mg/mL <1 mg/mL
S7465 FTI 277 HCl 17 mg/mL 96 mg/mL '14 mg/mL
S1958 Sulbactam 47 mg/mL 47 mg/mL 47 mg/mL
S3288 Absinthin -1 mg/mL 10 mg/mL -1 mg/mL
S5184 Dexamethasone palmitate <1 mg/mL 100 mg/mL ''100 mg/mL
S3269 Acetylcorynoline -1 mg/mL 40 mg/mL -1 mg/mL
S3270 Genipin 1-O-beta-D-gentiobioside -1 mg/mL 100 mg/mL -1 mg/mL
S3279 Polyphyllin B (Formosanin C) -1 mg/mL 100 mg/mL -1 mg/mL
S1282 Artemisinin <1 mg/mL 57 mg/mL 24 mg/mL
S2264 Artemether <1 mg/mL 60 mg/mL 60 mg/mL
S2479 Lincomycin HCl 89 mg/mL 89 mg/mL <1 mg/mL
S5961 Prednisolone disodium phosphate 97 mg/mL 97 mg/mL '''<1 mg/mL
S5963 Sulfathiazole sodium 55 mg/mL 55 mg/mL ''<1 mg/mL
P1201 LL37 (Human cathelicidin) 50 mg/mL -1 mg/mL '-1 mg/mL
S3364 3-Hydroxyphenylacetic acid 30 mg/mL 30 mg/mL '''30 mg/mL
S3218 Amiloxate ' mg/mL
S3210 3'-Hydroxy-4'-methoxyacetophenone <1 mg/mL 33 mg/mL 33 mg/mL
S1644 Nitrofural <1 mg/mL 40 mg/mL <1 mg/mL
S4237 Primaquine Diphosphate 91 mg/mL 91 mg/mL <1 mg/mL
S2469 Fleroxacin <1 mg/mL <1 mg/mL <1 mg/mL
S3116 Sulfathiazole <1 mg/mL 51 mg/mL <1 mg/mL
S2511 Sulfadoxine <1 mg/mL 62 mg/mL <1 mg/mL
S3067 Chlorhexidine 2HCl <1 mg/mL 100 mg/mL <1 mg/mL
S4147 Azithromycin Dihydrate 10 mg/mL 100 mg/mL 100 mg/mL
S4191 Betamipron <1 mg/mL 39 mg/mL 39 mg/mL
S2537 Secnidazole 37 mg/mL 37 mg/mL 37 mg/mL
S4195 Broxyquinoline <1 mg/mL 17 mg/mL <1 mg/mL
S4196 Ethacridine lactate monohydrate 5 mg/mL 72 mg/mL <1 mg/mL
S2612 Ribitol 30 mg/mL 30 mg/mL <1 mg/mL
S4726 Lauric Acid 20 mg/mL 40 mg/mL 40 mg/mL
S3941 Pinocembrin <1 mg/mL 51 mg/mL 51 mg/mL
S4579 Resorcinol 22 mg/mL 22 mg/mL 22 mg/mL
S9564 p-Hydroxy-cinnamic Acid <1 mg/mL 33 mg/mL 33 mg/mL
S6288 Chlorhexidine diacetate -1 mg/mL 100 mg/mL -1 mg/mL
S5366 Fipronil -1 mg/mL 87 mg/mL -1 mg/mL
S4420 Mefloquine HCl <1 mg/mL 82 mg/mL 82 mg/mL
S4142 Clopidol <1 mg/mL 1 mg/mL <1 mg/mL
S4592 Captisol (SBE-β-CD) 100 mg/mL <1 mg/mL <1 mg/mL
S5700 Phthalylsulfathiazole -1 mg/mL 80 mg/mL '-1 mg/mL
S4041 Olsalazine Sodium 41 mg/mL 4 mg/mL <1 mg/mL
S4250 Sulfamethoxypyridazine <1 mg/mL 56 mg/mL '<1 mg/mL
S5397 Chlorhexidine -1 mg/mL 100 mg/mL -1 mg/mL
S2271 Berberine chloride (NSC 646666) <1 mg/mL 40 mg/mL <1 mg/mL
S2282 Cinchonidine <1 mg/mL 59 mg/mL 59 mg/mL
S5475 Novaluron -1 mg/mL 99 mg/mL '-1 mg/mL
S4172 Cetylpyridinium Chloride 68 mg/mL 68 mg/mL 68 mg/mL
S6243 Ethyl pyruvate ' mg/mL
S3695 Cystamine dihydrochloride 45 mg/mL 14 mg/mL '2 mg/mL
S4175 Sulfaguanidine <1 mg/mL 43 mg/mL <1 mg/mL
S2395 Rheochrysidin <1 mg/mL 1 mg/mL <1 mg/mL
S3787 Picroside I -1 mg/mL 98 mg/mL -1 mg/mL
S9016 Dipsacoside B -1 mg/mL 100 mg/mL -1 mg/mL
S5908 Garenoxacin <1 mg/mL 2 mg/mL <1 mg/mL
S3649 Ceftazidime 100 mg/mL 4 mg/mL <1 mg/mL
S4062 Ronidazole <1 mg/mL 40 mg/mL <1 mg/mL
S4971 Buparvaquone <1 mg/mL 65 mg/mL '4 mg/mL
S6761 Dalfopristin <1 mg/mL 100 mg/mL ''''100 mg/mL
S4192 Chlorquinaldol <1 mg/mL 46 mg/mL 6 mg/mL
S5292 Diazolidinyl urea -1 mg/mL 55 mg/mL -1 mg/mL
S5887 Khellin <1 mg/mL 26 mg/mL 7 mg/mL
S4081 Sulfacetamide Sodium 51 mg/mL 19 mg/mL <1 mg/mL
S4759 p-Coumaric Acid <1 mg/mL 32 mg/mL '32 mg/mL
S7411 Ascomycin (FK520) <1 mg/mL 100 mg/mL 100 mg/mL
S0146 Broxaldine <1 mg/mL 30 mg/mL <1 mg/mL
S6019 2-Phenylphenol -1 mg/mL 34 mg/mL -1 mg/mL
S9387 Maackiain -1 mg/mL 56 mg/mL -1 mg/mL
S9084 Rhoifolin -1 mg/mL 100 mg/mL -1 mg/mL
S3801 Sodium Houttuyfonate <1 mg/mL 2 mg/mL <1 mg/mL
S2613 Clorsulon <1 mg/mL 76 mg/mL 7 mg/mL
S6442 Chlorphenesin 10 mg/mL 41 mg/mL 41 mg/mL
S9342 1,4-Naphthoquinone -1 mg/mL 32 mg/mL -1 mg/mL
S2564 Cloxacillin Sodium 55 mg/mL 55 mg/mL 25 mg/mL
S9112 Kaempferitrin -1 mg/mL 100 mg/mL -1 mg/mL
S5096 SulfadiMethoxine sodium -1 mg/mL 66 mg/mL '-1 mg/mL
S9113 Ononin -1 mg/mL 86 mg/mL -1 mg/mL
S5099 4-Aminophenylarsonic acid -1 mg/mL 43 mg/mL -1 mg/mL
S6459 Nifurtimox <1 mg/mL 57 mg/mL <1 mg/mL
S4232 Nithiamide <1 mg/mL 37 mg/mL <1 mg/mL
S3618 Acetylspiramycin (ASPM) <1 mg/mL 100 mg/mL '15 mg/mL
S4236 Proflavine Hemisulfate 22 mg/mL <1 mg/mL <1 mg/mL
S3746 Lumefantrine <1 mg/mL 13 mg/mL <1 mg/mL
S5212 Imidazolidinyl Urea -1 mg/mL 77 mg/mL '-1 mg/mL
S5210 Sulfamethazine Sodium Salt -1 mg/mL 60 mg/mL -1 mg/mL
S0443 Desciclovir 25 mg/mL 42 mg/mL '3 mg/mL
S4678 Povidone iodine 28 mg/mL 28 mg/mL '28 mg/mL
S9131 Punicalagin -1 mg/mL 100 mg/mL -1 mg/mL
S3139 Methenamine <1 mg/mL 28 mg/mL 9 mg/mL
S5405 Propylparaben <1 mg/mL 36 mg/mL 36 mg/mL
S4242 Cetrimonium Bromide (CTAB) 100 mg/mL 5 mg/mL 100 mg/mL
S5214 Imidocarb dipropionate -1 mg/mL 39 mg/mL -1 mg/mL
S6461 Permethrin <1 mg/mL 78 mg/mL 19 mg/mL
S3978 5-Phenyl-2,4-pentadienoic acid -1 mg/mL 6 mg/mL '-1 mg/mL
S5390 N-(Hytroxymethy)micotinamide -1 mg/mL 30 mg/mL '-1 mg/mL
S5355 Piperaquine phosphate 2 mg/mL <1 mg/mL -1 mg/mL
S9560 Anisodamine Hydrobromide -1 mg/mL 77 mg/mL -1 mg/mL
S5005 Cefotiam hydrochloride -1 mg/mL 100 mg/mL '-1 mg/mL
S1962 Sulphadimethoxine <1 mg/mL 62 mg/mL <1 mg/mL
S4555 Carsalam <1 mg/mL 32 mg/mL 2 mg/mL
S7896 Sodium Tauroursodeoxycholate (TUDC) 100 mg/mL 100 mg/mL 71 mg/mL
S9185 Nitidine Chloride -1 mg/mL 11 mg/mL -1 mg/mL

Anti-infection製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S5001

Tofacitinib (CP-690550) Citrate

Tofacitinib citrate (CP-690550, Tasocitinib) is a novel inhibitor of JAK with IC50 of 1 nM, 20 nM and 112 nM against JAK3, JAK2, and JAK1, respectively. Tofacitinib citrate has anti-infection activity.

S4157

Chloroquine diphosphate

Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Chloroquine is also an inhibitor of toll-like receptors (TLRs).

S5967

Berberine chloride hydrate

Berberine (Natural Yellow 18) chloride hydrate is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.

S4945

Ethacridine lactate

Ethacridine lactate (Acrinol) is an aromatic organic compound based on acridine used as an antiseptic agent. Ethacridine lactate is also a poly(ADP-ribose) glycohydrolase (PARG) inhibitor.

S4417

Ceftaroline Fosamil

Ceftaroline fosamil (CX-0903, DSP-5990, PPI-0903, TAK-599, Teflaro, Zinforo) is a cephalosporin with activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA).

S3226

Dehydroabietic acid

Dehydroabietic acid (DAA, DHAA), a naturally occurring diterpene resin acid derived from coniferous plants such as Pinus and Picea, displays anti-inflammatory activity via suppression of Src-, Syk-, and TAK1-mediated pathways.

S3308

Caftaric acid

Caftaric acid (CA, Caffeoyl tartaric acid) is a natural product that shows anti-oxidant and anti-inflammatory effects.

S3220

Trigonelline

Trigonelline (Trigenolline) is a plant alkaloid and a major component of coffee and fenugreek with anti-degranulation, anti-diabetic, antioxidant, anti-inflammatory, and neuroprotective effects. Trigonelline inhibits FcεRI-mediated intracellular signaling pathways, such as phosphorylation of PLCγ1, PI3K, and Akt. Trigonelline (Trigenolline) also inhibits the microtubule formation in RBL-2H3 cells.

S3261

Myrislignan

Myrislignan, a lignan isolated from Myristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan inhibits interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α). Myrislignan significantly inhibits the expressions of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) dose-dependently in LPS-stimulated macrophage cells. Myrislignan inhibits the NF-κB signalling pathway activation.

S2572

Streptomycin sulfate

Streptomycin sulfate is a sulfate salt of streptomycin that is a protein synthesis inhibitor.

S8279

Shikonin (C.I. 75535)

Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844), a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.

S1553

Delafloxacin (ABT-492)

Delafloxacin (ABT-492, RX-3341, WQ-3034) is a new fluoroquinolone against 155 aerobic and 171 anaerobic pathogens.

S4946

2,3-Dihydroxybenzoic acid

2,3-Dihydroxybenzoic acid (Pyrocatechuic acid, 3-Hydroxysalicylic acid, Hypogallic acid) is a natural phenol found in Phyllanthus acidus and in the aquatic fern Salvinia molesta, also a product of human aspirin metabolism. It is a potentially useful iron-chelating drug and has antimicrobial properties.

S8068

Chaetocin

Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively. Chaetocin is an anticancer agent and inhibitor of thioredoxin reductase (TrxR).

S4430

Hydroxychloroquine Sulfate (NSC 4375)

Hydroxychloroquine Sulfate (NSC 4375, HCQ) is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR) 7/9.

S4303

9-Aminoacridine

9-Aminoacridine (Aminacrine) is a highly fluorescent dye used clinically as a topical antiseptic and experimentally as a mutagen, an intracellular pH indicator and a negative mode small molecule MALDI matrix.

S5927

Proguanil

Proguanil (chlorguanide, chloroguanide) is a prophylactic antimalarial drug. It inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication.

S6771

MAC-545496

MAC-545496 is a nanomolar glycopeptide-resistance-associated protein R(GraR) inhibitor with strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM). MAC-545496 can reverse β-lactam resistance in methicillin-resistant strains and synergize with CAMPs. MAC-545496 shows remarkable activity in macrophages and attenuates S. aureus virulence in a G. mellonella larvae infection model.

S3711

Carbasalate Calcium

Carbasalate calcium (Iromin, Alcacyl, Omegin, Rheomin, Solupsan) is an analgesic, antipyretic, and anti-inflammatory drug as well as a platelet aggregation inhibitor.

S9341

3,4-Dimethoxycinnamic acid

3,4-Dimethoxycinnamic acid (Caffeic acid dimethyl ether) is a bioavailable coffee component as a perspective anti-prion compound and bind potently to prion protein with a Kd of 405 nM.

S4515

Ademetionine disulfate tosylate

Ademetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions. Ademetionine possesses anti-inflammatory activity and has been used in treatment of chronic liver disease.

S2430

Azodicarbonamide

Azodicarbonamide is the first known nucleocapsid inhibitor that inhibits HIV-1 and a broad range of retroviruses by targeting the nucleocapsid CCHC domains. Azodicarbonamide inhibits the HIV-1RF-induced cytopathicity of CEM-SS cells with an EC50 of 38 µM in a standard cell-based antiviral assay .

S6802

Etosalamide

Etosalamide (Ethosalamide) is an anti-inflammatory drug with antipyretic and analgesics properties.

S7867

Oleuropein

Oleuropein is an antioxidant polyphenol isolated from olive leaf. Oleuropein exerts antioxidant, anti-inflammatory and anti-atherogenic effects and suppresses the adipocyte differentiation in vitro. Oleuropein inhibits PPARγ activity. Oleuropein exerts anti-adipogenic effect through direct inhibition of PPARγ transcriptional activity. Oleuropein also inhibits aromatase. Oleuropein induces apoptosis. Phase 2.

S4549

Antimonyl potassium tartrate trihydrate

Antimonyl potassium tartrate trihydrate (Tartar emetic) is a powerful emetic, also used in the treatment of schistosomiasis and leishmaniasis.

S7465

FTI 277 HCl

FTI 277 HCl is the methyl ester of FTI 277, which is a potent and selective farnesyltransferase (FTase) inhibitor with IC50 of 500 pM, about 100-fold selectivity over the closely related GGTase I. FTI 277 HCl inhibits cell growth and induces apoptosis. FTI 277 HCl is effective in clearing HDV viremia.

S1958

Sulbactam

Sulbactam is a beta-lactamase inhibitor with an average IC50 of 0.8 μM.

S3288

Absinthin

Absinthin (Absynthine) is a naturally produced triterpene lactone from Artemisia absinthium with anti-inflammatory properties. Absinthin significantly enhances the expression of matrix metalloproteinase-8 (MMP-8) and is a possible treatment candidate for Acute lung injury (ALI).

S5184

Dexamethasone palmitate

Dexamethasone palmitate (DXP), a lipophilic prodrug of Dexamethasone (DXM), is a glucocorticoid receptor agonist with a 47-fold lower affinity for the glucocorticoid receptor than DXM. Dexamethasone palmitate (DXP) exhibits anti-inflammatory activity.

S3269

Acetylcorynoline

Acetylcorynoline, a major alkaloid component derived from Corydalis bungeana which is a traditional Chinese medical herb, shows anti-inflammatory properties. Acetylcorynoline may decrease egl-1 expression to suppress apoptosis pathways and increase rpn5 expression to enhance the activity of proteasomes.

S3270

Genipin 1-O-beta-D-gentiobioside

Genipin 1-O-beta-D-gentiobioside (GG, Genipin 1-β-D-gentiobioside, Genipin 1-gentiobioside, Genipin 1-β-gentiobioside, Genipin gentiobioside) is a bioactive iridoid glycoside isolated from Gardenia jasminoides Ellis (Zhizi in Chinese) that exhibits hepatoprotective, anti-inflammatory, antioxidant, and antithrombotic activities.

S3279

Polyphyllin B (Formosanin C)

Polyphyllin B (Formosanin C, FC), a diosgenin saponin isolated from Paris formosana, is an immunomodulator with antitumor activity. Polyphyllin B (Formosanin C, FC) induces apoptosis.

S1282

Artemisinin

Artemisinin (Qinghaosu, Artemisinine) is a sesquiterpene endoperoxide which is a potent antimalarial agent.

S2264

Artemether

Artemether (SM-224, CGP 56696) is an antimalarial for the treatment of resistant strains of falciparum malaria.

S2479

Lincomycin HCl

Lincomycin hydrochloride (Lincocin, NSC 70731) is the monohydrated salt of lincomycin, a substance produced by the growth of a member of the lincolnensis group of Streptomyces lincolnensis.

S5961

Prednisolone disodium phosphate

Prednisolone disodium phosphate (Hydeltrasol, Prednisolone 21-phosphate disodium) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties that exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells.

S5963

Sulfathiazole sodium

Sulfathiazole sodium, an antimicrobial agent, is an organosulfur compound that has been used as a short-acting sulfa drug.

P1201

LL37 (Human cathelicidin)

LL37 (Human cathelicidin, Ropocamptide) is a cathelicidin-related antimicrobial peptide with potent chemotactic and immunomodulatory properties.

S3364

3-Hydroxyphenylacetic acid

3-Hydroxyphenylacetic acid (3-HPAA) is a phenolic acid mostly found in olive oil wastewater and an intestinal metabolite of the dietary flavonoid quercetin. 3-Hydroxyphenylacetic acid exhibits antimicrobial properties.

S3218

Amiloxate

Amiloxate (Amiloxiate, Isoamyl Methoxycinnamate, Isopentyl 4-methoxycinnamate, Isoamyl 4-methoxycinnamate, Isoamyl p-methoxycinnamate, Isopentyl p-methoxycinnamate) is EMA-approved chemical UV-filter used in cosmetics. Amiloxate is a cinnamic acid derivative with anti-inflammatory activity.

S3210

3'-Hydroxy-4'-methoxyacetophenone

3'-Hydroxy-4'-methoxyacetophenone (Acetoisovanillone, Isoacetovanillone, Diosmin EP Impurity A) is an active P. spinosa extract with anti-inflammatory potential.

S1644

Nitrofural

Nitrofural (Nitrofurazone) is a topical anti-infective agent with an IC50 of 22.83 ± 1.2 μM. (Rat LD50 = 590 mg/kg)

S4237

Primaquine Diphosphate

Primaquine Diphosphate is a transmission-blocking anti-malarial clinically available, displaying a marked activity against gametocytes of all species of human malaria.

S2469

Fleroxacin

Fleroxacin (Ro 23-6240, AM-833) is a new broad-spectrum fluoroquinolone.

S3116

Sulfathiazole

Sulfathiazole is an organosulfur compound that has been used as a short-acting sulfa drug.

S2511

Sulfadoxine

Sulfadoxine (Sulphadoxine) is an ultra-long-lasting sulfonamide with an IC50 of 249 μg/ml for P. vivax.

S3067

Chlorhexidine 2HCl

Chlorhexidine hydrochloride (NSC-185) is an antiseptic effective against a wide variety of gram-negative and gram-positive organisms.

S4147

Azithromycin Dihydrate

Azithromycin Dihydrate is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin.

S4191

Betamipron

Betamipron (CS-443) is a chemical compound which is used together with panipenem to inhibit panipenem uptake into the renal tubule and prevent nephrotoxicity.

S2537

Secnidazole

Secnidazole (Flagentyl, PM 185184, RP 14539) is a nitroimidazole anti-infective.

S4195

Broxyquinoline

Broxyquinoline is an antiprotozoal agent and able to release oxygen free radicals from the water in mucous membranes.

S4196

Ethacridine lactate monohydrate

Ethacridine lactate monohydrate is an aromatic organic compound based on acridine used as an antiseptic agent.

S2612

Ribitol

Ribitol (Adonitol) is a crystalline pentose alcohol and is formed by the reduction of ribose which is occurs naturally in the plant Adonis vernalis.

S4726

Lauric Acid

Lauric Acid (dodecanoic acid, N-Dodecanoic acid, Dodecylic acid) is a saturated medium-chain fatty acid with a 12-carbon backbone. Lauric acid is found naturally in various plant and animal fats and oils, and is a major component of coconut oil and palm kernel oil.

S3941

Pinocembrin

Pinocembrin (Dihydrochrysin, Galangin flavanone, 5,7-Dihydroxyflavanone) is a major flavonoid molecule incorporated as multifunctional in the pharmaceutical industry. Its vast range of pharmacological activities has been well researched including antimicrobial, anti-inflammatory, antioxidant, and anticancer activities.

S4573

m-Tolyl acetate

m-Tolyl acetate is a pharmaceutical intermediate and antiseptic.

S4579

Resorcinol

Resorcinol is a chemical compound that serves as an antiseptic,an disinfectant, and a chemical intermediate for the production of many other pharmaceuticals.

S9564

p-Hydroxy-cinnamic Acid

p-Hydroxy-cinnamic Acid has in vitro antimalarial activity and in vivo anti-osteoporotic properties.

S6288

Chlorhexidine diacetate

Chlorhexidine diacetate (Hibitane diacetate) is a disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.

S5366

Fipronil

Fipronil (Fluocyanobenpyrazole, Termidor) is a recalcitrant phenylpyrazole-based pesticide used for flea/tick treatment and termite control that is distributed in urban aquatic environments via stormwater and contributes to stream toxicity.

S9094

Pogostone

Pogostone is one of the secondary metabolites from Pogostemon cablin (Blanco) Benth. (Lamiaceae), serving as the effective component of the antimicrobial activity.

S4420

Mefloquine HCl

Mefloquine HCl is a blood schizonticide by inhibiting hemozoin formation, used as an antimalarial drug.

S4142

Clopidol

Clopidol (WR 61112) is an antiprotozoal agent.

S4592

Captisol (SBE-β-CD)

Captisol (SBE-β-CD, Sulfobutylether-β-Cyclodextrin) is a novel, chemically modified cyclodextrin with a structure designed to optimize the solubility and stability of drugs.

S5700

Phthalylsulfathiazole

Phthalylsulfathiazole (Sulfathalidine) is a broad-spectrum antimicrobial that can treat different types of infections including intestinal.

S4041

Olsalazine Sodium

Olsalazine Sodium is an anti-inflammatory prodrug, which consists of two 5-ASA moieties linked by an azo bond.

S6136

(±)-α-Bisabolol

α-bisabolol is a small, plant-derived, oily sesquiterpene alcohol with some anti-inflammatory and even anti-microbial properties.

S5757

Isoeugenol

Isoeugenol (4-Propenylguaiacol), an essential oil constituent of nutmeg, clove, and cinnamon, shows antimicrobial activity.

S4250

Sulfamethoxypyridazine

Sulfamethoxypyridazine (CL 13494) is a long-acting sulfonamide for treatment of Dermatitis herpetiformis.

S5397

Chlorhexidine

Chlorhexidine is a disinfectant and topical anti-infective agent that is active against Gram-positive and Gram-negative organisms, facultative anaerobes, aerobes, and yeasts.

S6173

Amylmetacresol

Amylmetacresol is an antiseptic used to treat infections of the mouth and throat.

S6185

Arachidonic acid

Arachidonic acid (Arachidonate) is an unsaturated, essential fatty acid found in animal and human fat as well as in the liver, brain, and glandular organs. It is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes.

S2271

Berberine chloride (NSC 646666)

Berberine chloride (NSC 646666, Natural Yellow 18) is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.

S2282

Cinchonidine

Cinchonidine is an alkaloid used in asymmetric synthesis in organic chemistry.

S5475

Novaluron

Novaluron (Rimon) belongs to the class of insecticides called insect growth regulators with pesticide properties.

S4172

Cetylpyridinium Chloride

Cetylpyridinium chloride is a cationic quaternary ammonium compound used as oropharyngeal antiseptic.

S6243

Ethyl pyruvate

Ethyl pyruvate (CTI-01) is a simple aliphatic ester of pyruvic acid and has been shown to have robust neuroprotective effects via its anti-inflammatory, anti-oxidative, and anti-apoptotic functions.

S3695

Cystamine dihydrochloride

Cystamine dihydrochloride (Decarboxycystine, 2-Aminoethyl disulfide, 2,2'-Dithiobisethanamine) acts as an anti-infective agent, which is used in the treatment of urinary tract infections and also as a radiation-protective agent that interferes with sulfhydryl enzymes.

S4175

Sulfaguanidine

Sulfaguanidine is a sulfonamide used as an anti-infective agent.

S2395

Rheochrysidin

Rheochrysidin (Physcione) is an anthraquinone from roots of Rheum officinale Baill.

S3787

Picroside I

Picroside I (6'-Cinnamoylcatalpol), an iridoid glycoside, is a hepatoprotective agent which is reported to be antimicrobial and used against hepatitis B.

S9016

Dipsacoside B

Dipsacoside B, extracted from the flowerbuds of Lonicera confusa DC, shows strong antimicrobial activity.

S5908

Garenoxacin

Garenoxacin (T-3811ME, BMS-284756) is a novel des-F(6) quinolone that has been shown to be effective in vitro against a wide range of clinically important pathogens, including gram-positive and gram-negative aerobes and anaerobes.

S3649

Ceftazidime

Ceftazidime is a third-generation cephalosporin that has activity against Gram-negative bacilli, including Pseudomonas aeruginosa.

S4062

Ronidazole

Ronidazole is an antiprotozoal agent.

S4971

Buparvaquone

Buparvaquone (Butalex) is a second-generation hydroxynaphthoquinone related to parvaquone, with novel features that make it a promising compound for the therapy and prophylaxis of all forms of theileriosis.

S6761

Dalfopristin

Dalfopristin (RP54476) is a semi-synthetic analogue of ostreogyrcin A. Quinupristin/dalfopristin (Q/D) is a parental streptogramin with a spectrum of activity that includes Gram-positive pathogens, including those resistant to other classes of antimicrobial compounds.

S4192

Chlorquinaldol

Chlorquinaldol is an antimicrobial agent used for local antisepsy.

S5292

Diazolidinyl urea

Diazolidinyl urea (Germall II) is an antimicrobial preservative used in cosmetics.

S5887

Khellin

Khellin (Methafrone, Visammin, Ammivisnagen, Khellinorm, Medekellin, Viscardan, Kalangin), a compound isolated from the seeds of Ammi Visnaga Lam (Umbelliferae), is used to treat a variety of maladies.

S4081

Sulfacetamide Sodium

Sulfacetamide Sodium is an anti-biotic.

S4759

p-Coumaric Acid

p-Coumaric acid (4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, 4-Coumaric acid, Trans-p-Coumaric acid, para-Coumaric Acid) is a hydroxy derivative of cinnamic acid found in a variety of edible plants and is reported to have antioxidant, anti-inflammatory, and antimicrobial activity.

S7411

Ascomycin (FK520)

Ascomycin (FK520, FR 900520, Immunomycin), an FK-506 analog, is a neutral macrolide immunosuppressant, which prevents rejection after an organ transplant. Phase 3.

S0146

Broxaldine

Broxaldine (Brobenzoxaldine, AL307) is an antiprotozoal drug and can be used in leprosy.

S6019

2-Phenylphenol

2-Phenylphenol, found in lemon, is an antifungal agent and preservative used in food seasonings.

S9387

Maackiain

Maackiain (Demethylpterocarpin) is a pterocarpan that is widely distributed in leguminous plants. It has anticancer and antimicrobial effects.

S9084

Rhoifolin

Rhoifolin (Rhoifoloside, Apigenin 7-O-neohesperidoside, Apigenin-7-O-rhamnoglucoside), a natural glycoside of apigenin, has been obtained from the green leaves of Rhus succedanea and possesses a variety of significant biological activities including antioxidant, anti-inflammatory, antimicrobial, hepatoprotective and anticancer effects.

S3801

Sodium Houttuyfonate

Sodium Houttuyfonate, the active compound of the Houttuynia plant, is mainly used for treating purulent skin infections, respiratory tract infections, including pneumonia in elderly patients, and chronic bronchitis.

S2613

Clorsulon

Clorsulon (MK-401) is used in the treatment of Fasciola hepatica infections in calves and sheep.

S6442

Chlorphenesin

Chlorphenesin is a synthetic preservative used in skin care as a cosmetic biocide.

S9342

1,4-Naphthoquinone

1,4-Naphthoquinone (α-Naphthoquinone, para-naphthoquinone, P-Naphthoquinone), found in diesel exhaust particles and it is an active metabolite of naphthalene, is a fumigant insecticide.

S2564

Cloxacillin Sodium

Cloxacillin Sodium is a sodium salt of cloxacillin that is a penicillinase-resistant, acid resistant, semi-synthetic penicillin.

S9112

Kaempferitrin

Kaempferitrin (Lespenefril, Lespedin, Lespenephryl, Kaempferol 3,7-dirhamnoside), isolated from the leaves of Hedyotis verticillata and from Onychium japonicum, has antimicrobial, antioxidant, and anti-inflammatory activities.

S5096

SulfadiMethoxine sodium

Sulfadimethoxine (Sulfadimethoxydiazine) is a long-lasting sulfonamide antimicrobial agent used to treat many infections including treatment of respiratory, urinary tract, enteric, and soft tissue infections.

S9113

Ononin

Ononin (Formononetin glucoside, Formononetin 7-O-glucoside) is an isoflavone glycoside with anti-inflammtory effects.

S5099

4-Aminophenylarsonic acid

4-Aminophenylarsonic acid (Arsanilic Acid) is an organoarsenic compound with activity as an anti-infective agent.

S6459

Nifurtimox

Nifurtimox (BAY-2502) is an antiprotozoal agent.

S4232

Nithiamide

Nithiamide (CL 5279) is a non-5-nitroimidazole drugs.

S3618

Acetylspiramycin (ASPM)

Acetylspiramycin (ASPM, Spiramycin II, Foromacidin B) is a macrolide antimicrobial agent.

S4236

Proflavine Hemisulfate

Proflavine Hemisulfate is a topical antiseptic by interchelating DNA, thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands.

S3746

Lumefantrine

Lumefantrine (benflumetol) is an antimalarial agent used to treat acute uncomplicated malaria.

S5212

Imidazolidinyl Urea

Imidazolidinyl Urea (Imidurea) is an antimicrobial agent used as preservative in cosmetics.

S5210

Sulfamethazine Sodium Salt

Sulfamethazine (Sulfadimethyldiazine) is a sulfanilamide anti-infective agent used in the lifestock industry.

S0443

Desciclovir

Desciclovir (DCV, 6-Deoxyacyclovir, BW A515U) is a prodrug of the antiherpetic agent acyclovir (ACV) that converted into ACV by xanthine oxidase in humans.

S4678

Povidone iodine

Povidone iodine (Betadine, PVP iodine, PVP-I, Isodine) is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. It is used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol.

S9131

Punicalagin

Punicalagin, a major ellagitannin found in pomegranate extracts, has been shown to have antioxidant, anti-inflammatory, and anticancer effects.

S3139

Methenamine

Methenamine is an antibiotic used for the treatment of urinary tract infection.

S5405

Propylparaben

Propylparaben (Propyl 4-hydroxybenzoate, Propyl p-hydroxybenzoate, nipasol), a natural substance found in many plants and some insects, is an antimicrobial, preservative and flavouring agent.

S4242

Cetrimonium Bromide (CTAB)

Cetrimonium Bromide (CTAB) is a known component of the broad-spectrum antiseptic cetrimide, which is a mixture of different quaternary ammonium salts.

S5214

Imidocarb dipropionate

Imidocarb is an antiprotozoal agent, used as dipropionate in the treatment of babesiosis and ehrlichiosis.

S6461

Permethrin

Permethrin is a synthetic Type I pyrethroidal neurotoxic pesticide that has been responsible for accidental animal deaths.

S3978

5-Phenyl-2,4-pentadienoic acid

5-Phenyl-2,4-pentadienoic acid (5-Phenylpenta-2,4-dienoic acid) is used as Synthetic building block, anti-malarial agent.

S5390

N-(Hytroxymethy)micotinamide

N-(Hydroxymethyl)nicotinamide (Nikomethamide, Bilamid, N-hydroxymethylnicotinamide) is an antimicrobial agent.

S5355

Piperaquine phosphate

Piperaquine phosphate is an orally active bisquinolone antimalarial drug.

S9560

Anisodamine Hydrobromide

Anisodamine (6-Hydroxyhyoscyamine) is a naturally occurring atropine derivative and exhibits anti-inflammatory activity. It also inhibits α1-adrenergic receptors and muscarinic acetylcholine receptors (mAChRs).

S5005

Cefotiam hydrochloride

Cefotiam hydrochloride (Halospor, Pansporin, Pansporine) is the hydrochloride salt form of cefotiam and has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.

S1962

Sulphadimethoxine

Sulphadimethoxine is a non-reducing glucuronide.

S4555

Carsalam

Carsalam (Carbonylsalicylamide) is a nonsteroidal anti-inflammatory drug.

S7896

Sodium Tauroursodeoxycholate (TUDC)

Sodium Tauroursodeoxycholate (TUDC) is a water soluble bile salt, used for the treatment of gallstones and liver cirrhosis.

S4521

DEET

DEET (N,N-Diethyl-meta-toluamide, diethyltoluamide) is a commen active ingredient insect repellent.

S9185

Nitidine Chloride

Nitidine Chloride, a benzophenanthridine alkaloid found in species of the genus Zanthoxylum, has an anti-malarial activity.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S5001

Tofacitinib (CP-690550) Citrate

Tofacitinib citrate (CP-690550, Tasocitinib) is a novel inhibitor of JAK with IC50 of 1 nM, 20 nM and 112 nM against JAK3, JAK2, and JAK1, respectively. Tofacitinib citrate has anti-infection activity.

S4157

Chloroquine diphosphate

Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Chloroquine is also an inhibitor of toll-like receptors (TLRs).

S5967

Berberine chloride hydrate

Berberine (Natural Yellow 18) chloride hydrate is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.

S4945

Ethacridine lactate

Ethacridine lactate (Acrinol) is an aromatic organic compound based on acridine used as an antiseptic agent. Ethacridine lactate is also a poly(ADP-ribose) glycohydrolase (PARG) inhibitor.

S4417

Ceftaroline Fosamil

Ceftaroline fosamil (CX-0903, DSP-5990, PPI-0903, TAK-599, Teflaro, Zinforo) is a cephalosporin with activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA).

S3226

Dehydroabietic acid

Dehydroabietic acid (DAA, DHAA), a naturally occurring diterpene resin acid derived from coniferous plants such as Pinus and Picea, displays anti-inflammatory activity via suppression of Src-, Syk-, and TAK1-mediated pathways.

S3308

Caftaric acid

Caftaric acid (CA, Caffeoyl tartaric acid) is a natural product that shows anti-oxidant and anti-inflammatory effects.

S3220

Trigonelline

Trigonelline (Trigenolline) is a plant alkaloid and a major component of coffee and fenugreek with anti-degranulation, anti-diabetic, antioxidant, anti-inflammatory, and neuroprotective effects. Trigonelline inhibits FcεRI-mediated intracellular signaling pathways, such as phosphorylation of PLCγ1, PI3K, and Akt. Trigonelline (Trigenolline) also inhibits the microtubule formation in RBL-2H3 cells.

S3261

Myrislignan

Myrislignan, a lignan isolated from Myristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan inhibits interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α). Myrislignan significantly inhibits the expressions of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) dose-dependently in LPS-stimulated macrophage cells. Myrislignan inhibits the NF-κB signalling pathway activation.

S2572

Streptomycin sulfate

Streptomycin sulfate is a sulfate salt of streptomycin that is a protein synthesis inhibitor.

S8279

Shikonin (C.I. 75535)

Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844), a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.

S1553

Delafloxacin (ABT-492)

Delafloxacin (ABT-492, RX-3341, WQ-3034) is a new fluoroquinolone against 155 aerobic and 171 anaerobic pathogens.

S4946

2,3-Dihydroxybenzoic acid

2,3-Dihydroxybenzoic acid (Pyrocatechuic acid, 3-Hydroxysalicylic acid, Hypogallic acid) is a natural phenol found in Phyllanthus acidus and in the aquatic fern Salvinia molesta, also a product of human aspirin metabolism. It is a potentially useful iron-chelating drug and has antimicrobial properties.

S8068

Chaetocin

Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively. Chaetocin is an anticancer agent and inhibitor of thioredoxin reductase (TrxR).

S4430

Hydroxychloroquine Sulfate (NSC 4375)

Hydroxychloroquine Sulfate (NSC 4375, HCQ) is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR) 7/9.

S4303

9-Aminoacridine

9-Aminoacridine (Aminacrine) is a highly fluorescent dye used clinically as a topical antiseptic and experimentally as a mutagen, an intracellular pH indicator and a negative mode small molecule MALDI matrix.

S5927

Proguanil

Proguanil (chlorguanide, chloroguanide) is a prophylactic antimalarial drug. It inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication.

S6771

MAC-545496

MAC-545496 is a nanomolar glycopeptide-resistance-associated protein R(GraR) inhibitor with strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM). MAC-545496 can reverse β-lactam resistance in methicillin-resistant strains and synergize with CAMPs. MAC-545496 shows remarkable activity in macrophages and attenuates S. aureus virulence in a G. mellonella larvae infection model.

S3711

Carbasalate Calcium

Carbasalate calcium (Iromin, Alcacyl, Omegin, Rheomin, Solupsan) is an analgesic, antipyretic, and anti-inflammatory drug as well as a platelet aggregation inhibitor.

S9341

3,4-Dimethoxycinnamic acid

3,4-Dimethoxycinnamic acid (Caffeic acid dimethyl ether) is a bioavailable coffee component as a perspective anti-prion compound and bind potently to prion protein with a Kd of 405 nM.

S4515

Ademetionine disulfate tosylate

Ademetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions. Ademetionine possesses anti-inflammatory activity and has been used in treatment of chronic liver disease.

S2430

Azodicarbonamide

Azodicarbonamide is the first known nucleocapsid inhibitor that inhibits HIV-1 and a broad range of retroviruses by targeting the nucleocapsid CCHC domains. Azodicarbonamide inhibits the HIV-1RF-induced cytopathicity of CEM-SS cells with an EC50 of 38 µM in a standard cell-based antiviral assay .

S6802

Etosalamide

Etosalamide (Ethosalamide) is an anti-inflammatory drug with antipyretic and analgesics properties.

S7867

Oleuropein

Oleuropein is an antioxidant polyphenol isolated from olive leaf. Oleuropein exerts antioxidant, anti-inflammatory and anti-atherogenic effects and suppresses the adipocyte differentiation in vitro. Oleuropein inhibits PPARγ activity. Oleuropein exerts anti-adipogenic effect through direct inhibition of PPARγ transcriptional activity. Oleuropein also inhibits aromatase. Oleuropein induces apoptosis. Phase 2.

S4549

Antimonyl potassium tartrate trihydrate

Antimonyl potassium tartrate trihydrate (Tartar emetic) is a powerful emetic, also used in the treatment of schistosomiasis and leishmaniasis.

S7465

FTI 277 HCl

FTI 277 HCl is the methyl ester of FTI 277, which is a potent and selective farnesyltransferase (FTase) inhibitor with IC50 of 500 pM, about 100-fold selectivity over the closely related GGTase I. FTI 277 HCl inhibits cell growth and induces apoptosis. FTI 277 HCl is effective in clearing HDV viremia.

S1958

Sulbactam

Sulbactam is a beta-lactamase inhibitor with an average IC50 of 0.8 μM.

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S3288

Absinthin

Absinthin (Absynthine) is a naturally produced triterpene lactone from Artemisia absinthium with anti-inflammatory properties. Absinthin significantly enhances the expression of matrix metalloproteinase-8 (MMP-8) and is a possible treatment candidate for Acute lung injury (ALI).

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S5184

Dexamethasone palmitate

Dexamethasone palmitate (DXP), a lipophilic prodrug of Dexamethasone (DXM), is a glucocorticoid receptor agonist with a 47-fold lower affinity for the glucocorticoid receptor than DXM. Dexamethasone palmitate (DXP) exhibits anti-inflammatory activity.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S3269

Acetylcorynoline

Acetylcorynoline, a major alkaloid component derived from Corydalis bungeana which is a traditional Chinese medical herb, shows anti-inflammatory properties. Acetylcorynoline may decrease egl-1 expression to suppress apoptosis pathways and increase rpn5 expression to enhance the activity of proteasomes.

S3270

Genipin 1-O-beta-D-gentiobioside

Genipin 1-O-beta-D-gentiobioside (GG, Genipin 1-β-D-gentiobioside, Genipin 1-gentiobioside, Genipin 1-β-gentiobioside, Genipin gentiobioside) is a bioactive iridoid glycoside isolated from Gardenia jasminoides Ellis (Zhizi in Chinese) that exhibits hepatoprotective, anti-inflammatory, antioxidant, and antithrombotic activities.

S3279

Polyphyllin B (Formosanin C)

Polyphyllin B (Formosanin C, FC), a diosgenin saponin isolated from Paris formosana, is an immunomodulator with antitumor activity. Polyphyllin B (Formosanin C, FC) induces apoptosis.

2021, 22(1):550

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S1282

Artemisinin

Artemisinin (Qinghaosu, Artemisinine) is a sesquiterpene endoperoxide which is a potent antimalarial agent.

2021, 12:634368

2021, 95:107541

2020, 29:104810

S2264

Artemether

Artemether (SM-224, CGP 56696) is an antimalarial for the treatment of resistant strains of falciparum malaria.

2020, 19;20:58

2020, 10.1007/s13577-020-00420-z

2020, 10.1007/s13577-020-00425-8

S2479

Lincomycin HCl

Lincomycin hydrochloride (Lincocin, NSC 70731) is the monohydrated salt of lincomycin, a substance produced by the growth of a member of the lincolnensis group of Streptomyces lincolnensis.

2020, 19;20:58

2020, 10.1007/s13577-020-00425-8

2020, 10.1007/s13577-020-00420-z

S5961

Prednisolone disodium phosphate

Prednisolone disodium phosphate (Hydeltrasol, Prednisolone 21-phosphate disodium) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties that exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells.

2021, 10.5152/eurjrheum.2021.20054

S5963

Sulfathiazole sodium

Sulfathiazole sodium, an antimicrobial agent, is an organosulfur compound that has been used as a short-acting sulfa drug.

P1201

LL37 (Human cathelicidin)

LL37 (Human cathelicidin, Ropocamptide) is a cathelicidin-related antimicrobial peptide with potent chemotactic and immunomodulatory properties.

S3364

3-Hydroxyphenylacetic acid

3-Hydroxyphenylacetic acid (3-HPAA) is a phenolic acid mostly found in olive oil wastewater and an intestinal metabolite of the dietary flavonoid quercetin. 3-Hydroxyphenylacetic acid exhibits antimicrobial properties.

S3218

Amiloxate

Amiloxate (Amiloxiate, Isoamyl Methoxycinnamate, Isopentyl 4-methoxycinnamate, Isoamyl 4-methoxycinnamate, Isoamyl p-methoxycinnamate, Isopentyl p-methoxycinnamate) is EMA-approved chemical UV-filter used in cosmetics. Amiloxate is a cinnamic acid derivative with anti-inflammatory activity.

S3210

3'-Hydroxy-4'-methoxyacetophenone

3'-Hydroxy-4'-methoxyacetophenone (Acetoisovanillone, Isoacetovanillone, Diosmin EP Impurity A) is an active P. spinosa extract with anti-inflammatory potential.

S1644

Nitrofural

Nitrofural (Nitrofurazone) is a topical anti-infective agent with an IC50 of 22.83 ± 1.2 μM. (Rat LD50 = 590 mg/kg)

S4237

Primaquine Diphosphate

Primaquine Diphosphate is a transmission-blocking anti-malarial clinically available, displaying a marked activity against gametocytes of all species of human malaria.

2021, 12:695009

2019, 8(2):97-108

S2469

Fleroxacin

Fleroxacin (Ro 23-6240, AM-833) is a new broad-spectrum fluoroquinolone.

S3116

Sulfathiazole

Sulfathiazole is an organosulfur compound that has been used as a short-acting sulfa drug.

S2511

Sulfadoxine

Sulfadoxine (Sulphadoxine) is an ultra-long-lasting sulfonamide with an IC50 of 249 μg/ml for P. vivax.

S3067

Chlorhexidine 2HCl

Chlorhexidine hydrochloride (NSC-185) is an antiseptic effective against a wide variety of gram-negative and gram-positive organisms.

2020, 20(1):275

S4147

Azithromycin Dihydrate

Azithromycin Dihydrate is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin.

2020, 16(12):e1008489

2020, 2020.10.02.324228

2020, 2000034

S4191

Betamipron

Betamipron (CS-443) is a chemical compound which is used together with panipenem to inhibit panipenem uptake into the renal tubule and prevent nephrotoxicity.

S2537

Secnidazole

Secnidazole (Flagentyl, PM 185184, RP 14539) is a nitroimidazole anti-infective.

S4195

Broxyquinoline

Broxyquinoline is an antiprotozoal agent and able to release oxygen free radicals from the water in mucous membranes.

S4196

Ethacridine lactate monohydrate

Ethacridine lactate monohydrate is an aromatic organic compound based on acridine used as an antiseptic agent.

2014, 35(12):2822-30

S2612

Ribitol

Ribitol (Adonitol) is a crystalline pentose alcohol and is formed by the reduction of ribose which is occurs naturally in the plant Adonis vernalis.

S4726

Lauric Acid

Lauric Acid (dodecanoic acid, N-Dodecanoic acid, Dodecylic acid) is a saturated medium-chain fatty acid with a 12-carbon backbone. Lauric acid is found naturally in various plant and animal fats and oils, and is a major component of coconut oil and palm kernel oil.

S3941

Pinocembrin

Pinocembrin (Dihydrochrysin, Galangin flavanone, 5,7-Dihydroxyflavanone) is a major flavonoid molecule incorporated as multifunctional in the pharmaceutical industry. Its vast range of pharmacological activities has been well researched including antimicrobial, anti-inflammatory, antioxidant, and anticancer activities.

2020, 17(1):337

S4573

m-Tolyl acetate

m-Tolyl acetate is a pharmaceutical intermediate and antiseptic.

S4579

Resorcinol

Resorcinol is a chemical compound that serves as an antiseptic,an disinfectant, and a chemical intermediate for the production of many other pharmaceuticals.

S9564

p-Hydroxy-cinnamic Acid

p-Hydroxy-cinnamic Acid has in vitro antimalarial activity and in vivo anti-osteoporotic properties.

S6288

Chlorhexidine diacetate

Chlorhexidine diacetate (Hibitane diacetate) is a disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.

2020, 20(1):275

S5366

Fipronil

Fipronil (Fluocyanobenpyrazole, Termidor) is a recalcitrant phenylpyrazole-based pesticide used for flea/tick treatment and termite control that is distributed in urban aquatic environments via stormwater and contributes to stream toxicity.

S9094

Pogostone

Pogostone is one of the secondary metabolites from Pogostemon cablin (Blanco) Benth. (Lamiaceae), serving as the effective component of the antimicrobial activity.

2021, 278:114250

S4420

Mefloquine HCl

Mefloquine HCl is a blood schizonticide by inhibiting hemozoin formation, used as an antimalarial drug.

2021, 23(1)40

2020, 2020/9/20.4.7.30734

2018, 8(2):331-340

S4142

Clopidol

Clopidol (WR 61112) is an antiprotozoal agent.

S4592

Captisol (SBE-β-CD)

Captisol (SBE-β-CD, Sulfobutylether-β-Cyclodextrin) is a novel, chemically modified cyclodextrin with a structure designed to optimize the solubility and stability of drugs.

2021, S0092-8674(21)00690-5

2021, 10.1038/s41551-021-00718-9

2021, 34(11):108870

S5700

Phthalylsulfathiazole

Phthalylsulfathiazole (Sulfathalidine) is a broad-spectrum antimicrobial that can treat different types of infections including intestinal.

S4041

Olsalazine Sodium

Olsalazine Sodium is an anti-inflammatory prodrug, which consists of two 5-ASA moieties linked by an azo bond.

2017, 8(1):228-237

S6136

(±)-α-Bisabolol

α-bisabolol is a small, plant-derived, oily sesquiterpene alcohol with some anti-inflammatory and even anti-microbial properties.

S5757

Isoeugenol

Isoeugenol (4-Propenylguaiacol), an essential oil constituent of nutmeg, clove, and cinnamon, shows antimicrobial activity.

S4250

Sulfamethoxypyridazine

Sulfamethoxypyridazine (CL 13494) is a long-acting sulfonamide for treatment of Dermatitis herpetiformis.

S5397

Chlorhexidine

Chlorhexidine is a disinfectant and topical anti-infective agent that is active against Gram-positive and Gram-negative organisms, facultative anaerobes, aerobes, and yeasts.

2021, 10.1111/jcmm.16673

2020, 20(1):275

S6173

Amylmetacresol

Amylmetacresol is an antiseptic used to treat infections of the mouth and throat.

S6185

Arachidonic acid

Arachidonic acid (Arachidonate) is an unsaturated, essential fatty acid found in animal and human fat as well as in the liver, brain, and glandular organs. It is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes.

S2271

Berberine chloride (NSC 646666)

Berberine chloride (NSC 646666, Natural Yellow 18) is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.

2021, 12:632201

2021, 26(5)1210

2021, 10(3)250

S2282

Cinchonidine

Cinchonidine is an alkaloid used in asymmetric synthesis in organic chemistry.

2019, 91(8):1440-1447

S5475

Novaluron

Novaluron (Rimon) belongs to the class of insecticides called insect growth regulators with pesticide properties.

S4172

Cetylpyridinium Chloride

Cetylpyridinium chloride is a cationic quaternary ammonium compound used as oropharyngeal antiseptic.

S6243

Ethyl pyruvate

Ethyl pyruvate (CTI-01) is a simple aliphatic ester of pyruvic acid and has been shown to have robust neuroprotective effects via its anti-inflammatory, anti-oxidative, and anti-apoptotic functions.

S3695

Cystamine dihydrochloride

Cystamine dihydrochloride (Decarboxycystine, 2-Aminoethyl disulfide, 2,2'-Dithiobisethanamine) acts as an anti-infective agent, which is used in the treatment of urinary tract infections and also as a radiation-protective agent that interferes with sulfhydryl enzymes.

S4175

Sulfaguanidine

Sulfaguanidine is a sulfonamide used as an anti-infective agent.

S2395

Rheochrysidin

Rheochrysidin (Physcione) is an anthraquinone from roots of Rheum officinale Baill.

2015, 10.1021/cb5009487

S3787

Picroside I

Picroside I (6'-Cinnamoylcatalpol), an iridoid glycoside, is a hepatoprotective agent which is reported to be antimicrobial and used against hepatitis B.

S9016

Dipsacoside B

Dipsacoside B, extracted from the flowerbuds of Lonicera confusa DC, shows strong antimicrobial activity.

S5908

Garenoxacin

Garenoxacin (T-3811ME, BMS-284756) is a novel des-F(6) quinolone that has been shown to be effective in vitro against a wide range of clinically important pathogens, including gram-positive and gram-negative aerobes and anaerobes.

S3649

Ceftazidime

Ceftazidime is a third-generation cephalosporin that has activity against Gram-negative bacilli, including Pseudomonas aeruginosa.

S4062

Ronidazole

Ronidazole is an antiprotozoal agent.

S4971

Buparvaquone

Buparvaquone (Butalex) is a second-generation hydroxynaphthoquinone related to parvaquone, with novel features that make it a promising compound for the therapy and prophylaxis of all forms of theileriosis.

S6761

Dalfopristin

Dalfopristin (RP54476) is a semi-synthetic analogue of ostreogyrcin A. Quinupristin/dalfopristin (Q/D) is a parental streptogramin with a spectrum of activity that includes Gram-positive pathogens, including those resistant to other classes of antimicrobial compounds.

S4192

Chlorquinaldol

Chlorquinaldol is an antimicrobial agent used for local antisepsy.

S5292

Diazolidinyl urea

Diazolidinyl urea (Germall II) is an antimicrobial preservative used in cosmetics.

S5887

Khellin

Khellin (Methafrone, Visammin, Ammivisnagen, Khellinorm, Medekellin, Viscardan, Kalangin), a compound isolated from the seeds of Ammi Visnaga Lam (Umbelliferae), is used to treat a variety of maladies.

S4081

Sulfacetamide Sodium

Sulfacetamide Sodium is an anti-biotic.

2020, 4;10(5):1585-1597

S4759

p-Coumaric Acid

p-Coumaric acid (4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, 4-Coumaric acid, Trans-p-Coumaric acid, para-Coumaric Acid) is a hydroxy derivative of cinnamic acid found in a variety of edible plants and is reported to have antioxidant, anti-inflammatory, and antimicrobial activity.

2021, 21(5):503

2015, 26(11):1379-84

S7411

Ascomycin (FK520)

Ascomycin (FK520, FR 900520, Immunomycin), an FK-506 analog, is a neutral macrolide immunosuppressant, which prevents rejection after an organ transplant. Phase 3.

2020, 30(4):325-335

2019, 34(6):648-661

S0146

Broxaldine

Broxaldine (Brobenzoxaldine, AL307) is an antiprotozoal drug and can be used in leprosy.

S6019

2-Phenylphenol

2-Phenylphenol, found in lemon, is an antifungal agent and preservative used in food seasonings.

S9387

Maackiain

Maackiain (Demethylpterocarpin) is a pterocarpan that is widely distributed in leguminous plants. It has anticancer and antimicrobial effects.

S9084

Rhoifolin

Rhoifolin (Rhoifoloside, Apigenin 7-O-neohesperidoside, Apigenin-7-O-rhamnoglucoside), a natural glycoside of apigenin, has been obtained from the green leaves of Rhus succedanea and possesses a variety of significant biological activities including antioxidant, anti-inflammatory, antimicrobial, hepatoprotective and anticancer effects.

S3801

Sodium Houttuyfonate

Sodium Houttuyfonate, the active compound of the Houttuynia plant, is mainly used for treating purulent skin infections, respiratory tract infections, including pneumonia in elderly patients, and chronic bronchitis.

S2613

Clorsulon

Clorsulon (MK-401) is used in the treatment of Fasciola hepatica infections in calves and sheep.

2020, 19;20:58

2020, 10.1007/s13577-020-00425-8

2020, 10.1007/s13577-020-00420-z

S6442

Chlorphenesin

Chlorphenesin is a synthetic preservative used in skin care as a cosmetic biocide.

S9342

1,4-Naphthoquinone

1,4-Naphthoquinone (α-Naphthoquinone, para-naphthoquinone, P-Naphthoquinone), found in diesel exhaust particles and it is an active metabolite of naphthalene, is a fumigant insecticide.

S2564

Cloxacillin Sodium

Cloxacillin Sodium is a sodium salt of cloxacillin that is a penicillinase-resistant, acid resistant, semi-synthetic penicillin.

S9112

Kaempferitrin

Kaempferitrin (Lespenefril, Lespedin, Lespenephryl, Kaempferol 3,7-dirhamnoside), isolated from the leaves of Hedyotis verticillata and from Onychium japonicum, has antimicrobial, antioxidant, and anti-inflammatory activities.

S5096

SulfadiMethoxine sodium

Sulfadimethoxine (Sulfadimethoxydiazine) is a long-lasting sulfonamide antimicrobial agent used to treat many infections including treatment of respiratory, urinary tract, enteric, and soft tissue infections.

2018, 9(6):646

S9113

Ononin

Ononin (Formononetin glucoside, Formononetin 7-O-glucoside) is an isoflavone glycoside with anti-inflammtory effects.

S5099

4-Aminophenylarsonic acid

4-Aminophenylarsonic acid (Arsanilic Acid) is an organoarsenic compound with activity as an anti-infective agent.

S6459

Nifurtimox

Nifurtimox (BAY-2502) is an antiprotozoal agent.

S4232

Nithiamide

Nithiamide (CL 5279) is a non-5-nitroimidazole drugs.

S3618

Acetylspiramycin (ASPM)

Acetylspiramycin (ASPM, Spiramycin II, Foromacidin B) is a macrolide antimicrobial agent.

S4236

Proflavine Hemisulfate

Proflavine Hemisulfate is a topical antiseptic by interchelating DNA, thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands.

S3746

Lumefantrine

Lumefantrine (benflumetol) is an antimalarial agent used to treat acute uncomplicated malaria.

2021, AAC.02137-20

2020, 10.1021/acsinfecdis.0c00522

S5212

Imidazolidinyl Urea

Imidazolidinyl Urea (Imidurea) is an antimicrobial agent used as preservative in cosmetics.

S5210

Sulfamethazine Sodium Salt

Sulfamethazine (Sulfadimethyldiazine) is a sulfanilamide anti-infective agent used in the lifestock industry.

S0443

Desciclovir

Desciclovir (DCV, 6-Deoxyacyclovir, BW A515U) is a prodrug of the antiherpetic agent acyclovir (ACV) that converted into ACV by xanthine oxidase in humans.

S4678

Povidone iodine

Povidone iodine (Betadine, PVP iodine, PVP-I, Isodine) is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. It is used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol.

S9131

Punicalagin

Punicalagin, a major ellagitannin found in pomegranate extracts, has been shown to have antioxidant, anti-inflammatory, and anticancer effects.

2020, 30;181(3):637-652.e15.

2020, 30;181(3):637-652e15

S3139

Methenamine

Methenamine is an antibiotic used for the treatment of urinary tract infection.

S5405

Propylparaben

Propylparaben (Propyl 4-hydroxybenzoate, Propyl p-hydroxybenzoate, nipasol), a natural substance found in many plants and some insects, is an antimicrobial, preservative and flavouring agent.

S4242

Cetrimonium Bromide (CTAB)

Cetrimonium Bromide (CTAB) is a known component of the broad-spectrum antiseptic cetrimide, which is a mixture of different quaternary ammonium salts.

2021, 10.1139/bcb-2020-0570

2018, 9(6)

S5214

Imidocarb dipropionate

Imidocarb is an antiprotozoal agent, used as dipropionate in the treatment of babesiosis and ehrlichiosis.

2017, 8(1):823

S6461

Permethrin

Permethrin is a synthetic Type I pyrethroidal neurotoxic pesticide that has been responsible for accidental animal deaths.

S3978

5-Phenyl-2,4-pentadienoic acid

5-Phenyl-2,4-pentadienoic acid (5-Phenylpenta-2,4-dienoic acid) is used as Synthetic building block, anti-malarial agent.

S5390

N-(Hytroxymethy)micotinamide

N-(Hydroxymethyl)nicotinamide (Nikomethamide, Bilamid, N-hydroxymethylnicotinamide) is an antimicrobial agent.

S5355

Piperaquine phosphate

Piperaquine phosphate is an orally active bisquinolone antimalarial drug.

S9560

Anisodamine Hydrobromide

Anisodamine (6-Hydroxyhyoscyamine) is a naturally occurring atropine derivative and exhibits anti-inflammatory activity. It also inhibits α1-adrenergic receptors and muscarinic acetylcholine receptors (mAChRs).

S5005

Cefotiam hydrochloride

Cefotiam hydrochloride (Halospor, Pansporin, Pansporine) is the hydrochloride salt form of cefotiam and has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.

S1962

Sulphadimethoxine

Sulphadimethoxine is a non-reducing glucuronide.

S4555

Carsalam

Carsalam (Carbonylsalicylamide) is a nonsteroidal anti-inflammatory drug.

S7896

Sodium Tauroursodeoxycholate (TUDC)

Sodium Tauroursodeoxycholate (TUDC) is a water soluble bile salt, used for the treatment of gallstones and liver cirrhosis.

2019, 7(1):145

2019, 15(9):1905-1920

2018, 37:269-280

S4521

DEET

DEET (N,N-Diethyl-meta-toluamide, diethyltoluamide) is a commen active ingredient insect repellent.

S9185

Nitidine Chloride

Nitidine Chloride, a benzophenanthridine alkaloid found in species of the genus Zanthoxylum, has an anti-malarial activity.