Anti-infection
阻害剤の選択性比較
カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
---|---|---|---|---|
水 | DMSO | アルコール | ||
S1047 | Vorinostat (SAHA) | <1 mg/mL | 52 mg/mL | 3 mg/mL |
S1009 | Dactolisib (BEZ235) | <1 mg/mL | 0.01 mg/mL | <1 mg/mL |
S1102 | U0126-EtOH | <1 mg/mL | 85 mg/mL | <1 mg/mL |
S5001 | Tofacitinib (CP-690550) Citrate | <1 mg/mL | 100 mg/mL | <1 mg/mL |
S3500 | Pentosan Polysulfate Sodium | 100 mg/mL | <1 mg/mL | '<1 mg/mL |
S3499 | Monocaprylin | <1 mg/mL | 44 mg/mL | ''44 mg/mL |
S3496 | Lefamulin acetate (Xenleta) | 100 mg/mL | 100 mg/mL | '''''100 mg/mL |
S3356 | Phosphonoacetic acid | 28 mg/mL | 28 mg/mL | '''28 mg/mL |
S3380 | Tecovirimat | <1 mg/mL | 75 mg/mL | '''''75 mg/mL |
S4417 | Ceftaroline Fosamil | <1 mg/mL | 73 mg/mL | ''''<1 mg/mL |
S3226 | Dehydroabietic acid | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S3295 | Taxifolin 7-rhamnoside | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S3307 | Galangin 3-methyl ether | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S3308 | Caftaric acid | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S3220 | Trigonelline | -1 mg/mL | 50 mg/mL | -1 mg/mL |
S3261 | Myrislignan | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S9669 | U18666A | 40 mg/mL | 30 mg/mL | ''''85 mg/mL |
S6867 | Glyceryl monocaprate (Monocaprin) | <1 mg/mL | 49 mg/mL | '49 mg/mL |
S2764 | DTNB | <1 mg/mL | 79 mg/mL | 79 mg/mL |
S6801 | AKOS B018304 | <1 mg/mL | 53 mg/mL | 2 mg/mL |
S6802 | Etosalamide | 6 mg/mL | 42 mg/mL | '42 mg/mL |
S8512 | Cenicriviroc | <1 mg/mL | 100 mg/mL | 100 mg/mL |
S6845 | GRL0617 | <1 mg/mL | 65 mg/mL | 22 mg/mL |
S7418 | Cycloheximide | 15 mg/mL | 56 mg/mL | ''56 mg/mL |
S6848 | 3'-Fluoro-3'-deoxythymidine (Alovudine) | 20 mg/mL | 49 mg/mL | '40 mg/mL |
S0833 | EIDD-1931 | 15 mg/mL | -1 mg/mL | '3 mg/mL |
S8969 | Molnupiravir (EIDD-2801) | 20 mg/mL | 66 mg/mL | '22 mg/mL |
S0515 | PLpro inhibitor | <1 mg/mL | 69 mg/mL | '''35 mg/mL |
S0433 | Nucleozin | <1 mg/mL | 15 mg/mL | <1 mg/mL |
S0436 | Pleconaril | ˂1 mg/mL | 76 mg/mL | 76 mg/mL |
S0467 | Emodepside | <1 mg/mL | 100 mg/mL | 20 mg/mL |
S0470 | RSV604 | ˂1 mg/mL | 78 mg/mL | '9 mg/mL |
S0491 | Manogepix (E1210) | <1 mg/mL | 72 mg/mL | 20 mg/mL |
S0285 | Bay 41-4109 racemate | ˂1 mg/mL | 79 mg/mL | '11 mg/mL |
S0289 | KIN1148 | <1 mg/mL | 84 mg/mL | ''''14 mg/mL |
S0147 | KKL-10 | <1 mg/mL | 3 mg/mL | <1 mg/mL |
S0195 | Walrycin B | ' mg/mL | ||
S6814 | GS-441524 | <1 mg/mL | 58 mg/mL | <1 mg/mL |
S5183 | PD 169316 | <1 mg/mL | 14 mg/mL | <1 mg/mL |
S0076 | ABX464 | <1 mg/mL | 68 mg/mL | 68 mg/mL |
S0038 | AB-423 | ˂1 mg/mL | 77 mg/mL | 77 mg/mL |
S6689 | Merimepodib | <1 mg/mL | 90 mg/mL | <1 mg/mL |
S6771 | MAC-545496 | ˂1 mg/mL | 84 mg/mL | ˂1 mg/mL |
S8932 | Remdesivir (GS-5734) | <1 mg/mL | 100 mg/mL | '''16 mg/mL |
S6676 | Ebselen | <1 mg/mL | 55 mg/mL | <1 mg/mL |
S1230 | Flavopiridol (Alvocidib) | <1 mg/mL | 15 mg/mL | 8 mg/mL |
S2003 | Maraviroc | <1 mg/mL | 100 mg/mL | 100 mg/mL |
S2679 | Flavopiridol HCl | <1 mg/mL | 88 mg/mL | <1 mg/mL |
S2728 | AG-1478 (Tyrphostin AG-1478) | <1 mg/mL | 25 mg/mL | 13 mg/mL |
S1209 | Fluorouracil (5-Fluorouracil, 5-FU) | <1 mg/mL | 26 mg/mL | <1 mg/mL |
S1537 | DMXAA (Vadimezan) | <1 mg/mL | 7 mg/mL | <1 mg/mL |
S1117 | Triciribine | <1 mg/mL | 64 mg/mL | <1 mg/mL |
S1516 | Cidofovir | 12 mg/mL | 2 mg/mL | <1 mg/mL |
S1228 | Idarubicin HCl | 5 mg/mL | 100 mg/mL | <1 mg/mL |
S1442 | Voriconazole | <1 mg/mL | 70 mg/mL | 20 mg/mL |
S7046 | Brefeldin A | <1 mg/mL | 4 mg/mL | <1 mg/mL |
S1189 | Aprepitant | <1 mg/mL | 107 mg/mL | 15 mg/mL |
S2713 | Geldanamycin | <1 mg/mL | 36 mg/mL | <1 mg/mL |
S1401 | Tenofovir | 2 mg/mL | 4 mg/mL | <1 mg/mL |
S7015 | Birinapant | <1 mg/mL | 100 mg/mL | 55 mg/mL |
S1400 | Tenofovir Disoproxil Fumarate | <1 mg/mL | 100 mg/mL | 44 mg/mL |
S1704 | Emtricitabine | 49 mg/mL | 49 mg/mL | 9 mg/mL |
S2597 | Oseltamivir Phosphate | <1 mg/mL | 4 mg/mL | <1 mg/mL |
S3021 | Rimonabant | <1 mg/mL | 25 mg/mL | ''2 mg/mL |
S8030 | Plerixafor (AMD3100) | 3 mg/mL | <1 mg/mL | 100 mg/mL |
S1896 | Hydroxyurea | 15 mg/mL | 15 mg/mL | <1 mg/mL |
S1386 | Nafamostat Mesylate | 53 mg/mL | 20 mg/mL | <1 mg/mL |
S1627 | Nitazoxanide | <1 mg/mL | 62 mg/mL | <1 mg/mL |
S1623 | Acetylcysteine (N-acetylcysteine) | 33 mg/mL | 33 mg/mL | '33 mg/mL |
S1384 | Mizoribine | 51 mg/mL | 1 mg/mL | <1 mg/mL |
S8047 | Dynasore | <1 mg/mL | 64 mg/mL | <1 mg/mL |
S1848 | Curcumin | <1 mg/mL | 73 mg/mL | <1 mg/mL |
S4157 | Chloroquine diphosphate | 100 mg/mL | <1 mg/mL | <1 mg/mL |
S2310 | Honokiol | <1 mg/mL | 53 mg/mL | <1 mg/mL |
S2239 | Tubacin | <1 mg/mL | 100 mg/mL | <1 mg/mL |
S1351 | Ivermectin | <1 mg/mL | 100 mg/mL | 28 mg/mL |
S2527 | Methacycline HCl | 5 mg/mL | 3 mg/mL | <1 mg/mL |
S1677 | Chloramphenicol | <1 mg/mL | 65 mg/mL | 65 mg/mL |
S2716 | Peramivir Trihydrate | <1 mg/mL | 0.2 mg/mL | <1 mg/mL |
S1606 | Clotrimazole | <1 mg/mL | 11 mg/mL | 69 mg/mL |
S1956 | Miconazole Nitrate | <1 mg/mL | 96 mg/mL | 1 mg/mL |
S2557 | Terbinafine HCl | <1 mg/mL | 66 mg/mL | 66 mg/mL |
S2457 | Clindamycin HCl | 92 mg/mL | 92 mg/mL | <1 mg/mL |
S1611 | Cefoperazone | <1 mg/mL | 100 mg/mL | <1 mg/mL |
S3007 | Zanamivir | 25 mg/mL | 2 mg/mL | <1 mg/mL |
S2908 | Hygromycin B | 100 mg/mL | <1 mg/mL | <1 mg/mL |
S1854 | Bifonazole | <1 mg/mL | 62 mg/mL | 20 mg/mL |
S1876 | Valaciclovir HCl | 72 mg/mL | 14 mg/mL | <1 mg/mL |
S1997 | Liranaftate | <1 mg/mL | <1 mg/mL | <1 mg/mL |
S1791 | Bacitracin Zinc | <1 mg/mL | 100 mg/mL | <1 mg/mL |
S2572 | Streptomycin sulfate | 89 mg/mL | <1 mg/mL | <1 mg/mL |
S1618 | Sulfameter | <1 mg/mL | 56 mg/mL | <1 mg/mL |
S1685 | Sulfanilamide | <1 mg/mL | 34 mg/mL | 17 mg/mL |
S8279 | Shikonin | <1 mg/mL | 57 mg/mL | 23 mg/mL |
S8750 | NGI-1 (ML414) | <1 mg/mL | 79 mg/mL | <1 mg/mL |
S5144 | Neferine | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S2830 | Clindamycin | <1 mg/mL | 85 mg/mL | 85 mg/mL |
S7311 | Q-VD-Oph | <1 mg/mL | 100 mg/mL | 100 mg/mL |
S5268 | Solithromycin | <1 mg/mL | 100 mg/mL | '25 mg/mL |
S4970 | Nerol | ' mg/mL | ||
S7975 | Favipiravir (T-705) | 5 mg/mL | 31 mg/mL | 22 mg/mL |
S7550 | Erythromycin Cyclocarbonate | <1 mg/mL | 100 mg/mL | 100 mg/mL |
S7784 | Fumagillin | <1 mg/mL | 92 mg/mL | 32 mg/mL |
S4861 | Oxindole | -1 mg/mL | 26 mg/mL | '-1 mg/mL |
S8873 | Letermovir (AIC246) | <1 mg/mL | 100 mg/mL | '100 mg/mL |
S4946 | 2,3-Dihydroxybenzoic acid | -1 mg/mL | 30 mg/mL | -1 mg/mL |
S4647 | Cefmenoxime hydrochloride | <1 mg/mL | 70 mg/mL | <1 mg/mL |
S5499 | Amantadine | -1 mg/mL | 1 mg/mL | '-1 mg/mL |
S4602 | Acetohydroxamic acid | 15 mg/mL | 15 mg/mL | 15 mg/mL |
S8133 | Resiquimod | <1 mg/mL | 63 mg/mL | '21 mg/mL |
S8588 | ACSS2 inhibitor | <1 mg/mL | 7 mg/mL | 2 mg/mL |
S6549 | PBTZ169 | <1 mg/mL | 5 mg/mL | 4 mg/mL |
S9303 | Saikosaponin B2 | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S9018 | Luteoloside | -1 mg/mL | 89 mg/mL | -1 mg/mL |
S7775 | Emricasan | <1 mg/mL | 100 mg/mL | '100 mg/mL |
S7273 | SC75741 | <1 mg/mL | 35 mg/mL | <1 mg/mL |
S8068 | Chaetocin | <1 mg/mL | 100 mg/mL | <1 mg/mL |
S9063 | Harringtonine | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S4430 | Hydroxychloroquine Sulfate | 67 mg/mL | <1 mg/mL | <1 mg/mL |
S9064 | Trilobatin | -1 mg/mL | 87 mg/mL | -1 mg/mL |
S4303 | 9-Aminoacridine | <1 mg/mL | 38 mg/mL | '38 mg/mL |
S5704 | Myclobutanil | -1 mg/mL | 58 mg/mL | -1 mg/mL |
S4983 | Sorbic acid | <1 mg/mL | 22 mg/mL | 22 mg/mL |
S9070 | Isoxanthohumol | -1 mg/mL | 70 mg/mL | -1 mg/mL |
S4198 | Aminothiazole | 20 mg/mL | 20 mg/mL | 20 mg/mL |
S9072 | Sweroside | -1 mg/mL | 71 mg/mL | -1 mg/mL |
S5927 | Proguanil | <1 mg/mL | 51 mg/mL | 51 mg/mL |
S3710 | Fosfomycin calcium | <1 mg/mL | 0.1 mg/mL | <1 mg/mL |
S5166 | Benzoyleneurea | -1 mg/mL | 32 mg/mL | -1 mg/mL |
S5025 | Efinaconazole | <1 mg/mL | 69 mg/mL | 69 mg/mL |
S4104 | Diminazene Aceturate | 100 mg/mL | 19 mg/mL | <1 mg/mL |
S4105 | Closantel Sodium | <1 mg/mL | 100 mg/mL | 100 mg/mL |
S4106 | Closantel | <1 mg/mL | 100 mg/mL | <1 mg/mL |
S3711 | Carbasalate Calcium | 91 mg/mL | 11 mg/mL | <1 mg/mL |
S4701 | 2-Deoxy-D-glucose (2-DG) | 32 mg/mL | 32 mg/mL | 1 mg/mL |
S9341 | 3,4-Dimethoxycinnamic acid | -1 mg/mL | 42 mg/mL | -1 mg/mL |
S4515 | Ademetionine disulfate tosylate | 79 mg/mL | 79 mg/mL | <1 mg/mL |
S3028 | Geneticin (G418 Sulfate) | 100 mg/mL | <1 mg/mL | <1 mg/mL |
S7417 | Puromycin 2HCl | 100 mg/mL | 100 mg/mL | <1 mg/mL |
S4780 | 7-Methoxy-4-methylcoumarin | -1 mg/mL | 38 mg/mL | -1 mg/mL |
S4783 | Benzyl isothiocyanate | -1 mg/mL | 29 mg/mL | -1 mg/mL |
S7867 | Oleuropein | 100 mg/mL | 100 mg/mL | 100 mg/mL |
S4549 | Antimonyl potassium tartrate trihydrate | 100 mg/mL | <1 mg/mL | <1 mg/mL |
S7889 | Xanthohumol | <1 mg/mL | 70 mg/mL | 70 mg/mL |
S4286 | Anidulafungin (LY303366) | <1 mg/mL | 100 mg/mL | <1 mg/mL |
S7419 | Blasticidin S HCl | 91 mg/mL | <1 mg/mL | <1 mg/mL |
S7465 | FTI 277 HCl | 17 mg/mL | 96 mg/mL | '14 mg/mL |
S4854 | Bedaquiline fumarate | <1 mg/mL | 100 mg/mL | 4 mg/mL |
S1958 | Sulbactam | 47 mg/mL | 47 mg/mL | 47 mg/mL |
S3288 | Absinthin | -1 mg/mL | 10 mg/mL | -1 mg/mL |
S4389 | Bephenium Hydroxynaphthoate | <1 mg/mL | 88 mg/mL | '<1 mg/mL |
S0349 | Inarigivir soproxil | 25 mg/mL | 100 mg/mL | '''''60 mg/mL |
S3251 | Goitrin | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S3269 | Acetylcorynoline | -1 mg/mL | 40 mg/mL | -1 mg/mL |
S3270 | Genipin 1-O-beta-D-gentiobioside | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S3279 | Polyphyllin B (Formosanin C) | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S1208 | Doxorubicin (Adriamycin) HCl | 20 mg/mL | 100 mg/mL | <1 mg/mL |
P1201 | LL37 (Human cathelicidin) | 50 mg/mL | -1 mg/mL | -1 mg/mL |
S3350 | Cholesteryl linoleate | 100 mg/mL | 100 mg/mL | '''100 mg/mL |
S3364 | 3-Hydroxyphenylacetic acid | 30 mg/mL | 30 mg/mL | '''30 mg/mL |
S2869 | Adamantane | <1 mg/mL | <1 mg/mL | 15 mg/mL |
S3218 | Amiloxate | ' mg/mL | ||
S3280 | Linderene | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S3210 | 3'-Hydroxy-4'-methoxyacetophenone | <1 mg/mL | 33 mg/mL | 33 mg/mL |
S0917 | Allosecurinin | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S0906 | 6-Methoxydihydrosanguinarine | <1 mg/mL | 73 mg/mL | 1.5 mg/mL |
S6854 | Triazavirin | 20 mg/mL | 57 mg/mL | <1 mg/mL |
S4408 | Procodazole | <1 mg/mL | 38 mg/mL | ''<1 mg/mL |
S0443 | Desciclovir | 25 mg/mL | 42 mg/mL | '3 mg/mL |
S0146 | Broxaldine | <1 mg/mL | 30 mg/mL | <1 mg/mL |
S9466 | Methenamine Hippurate | -1 mg/mL | 14 mg/mL | -1 mg/mL |
S3013 | Plerixafor (AMD3100) 8HCl | 100 mg/mL | <1 mg/mL | <1 mg/mL |
S1373 | Daptomycin | 100 mg/mL | 100 mg/mL | <1 mg/mL |
S1408 | Linezolid | <1 mg/mL | 67 mg/mL | 8 mg/mL |
S1097 | BTZ043 Racemate | <1 mg/mL | 22 mg/mL | <1 mg/mL |
S1517 | Natamycin | <1 mg/mL | 7 mg/mL | <1 mg/mL |
S1403 | Tigecycline | 100 mg/mL | 100 mg/mL | <1 mg/mL |
S1878 | Ganciclovir | <1 mg/mL | 27 mg/mL | <1 mg/mL |
S2504 | Ribavirin | 49 mg/mL | 49 mg/mL | <1 mg/mL |
S1807 | Aciclovir | <1 mg/mL | 45 mg/mL | <1 mg/mL |
S1374 | Doripenem Hydrate | 26 mg/mL | 36 mg/mL | <1 mg/mL |
S1381 | Meropenem | 8 mg/mL | 76 mg/mL | <1 mg/mL |
S1162 | Pretomanid (PA-824) | <1 mg/mL | 72 mg/mL | 16 mg/mL |
S1934 | Nystatin (Fungicidin) | <1 mg/mL | 19 mg/mL | <1 mg/mL |
S1741 | Rifabutin | <1 mg/mL | 60 mg/mL | 40 mg/mL |
S1370 | Biapenem | 16 mg/mL | <1 mg/mL | <1 mg/mL |
S1371 | Cefoselis Sulfate | 5 mg/mL | 3 mg/mL | <1 mg/mL |
S2159 | Tebipenem Pivoxil | <1 mg/mL | 99 mg/mL | 87 mg/mL |
S1636 | Amphotericin B | <1 mg/mL | 22 mg/mL | <1 mg/mL |
S1282 | Artemisinin | <1 mg/mL | 57 mg/mL | 24 mg/mL |
S1399 | Teicoplanin | 100 mg/mL | <1 mg/mL | <1 mg/mL |
S1505 | Aztreonam | 11 mg/mL | 87 mg/mL | <1 mg/mL |
S1725 | Terbinafine | <1 mg/mL | 58 mg/mL | 58 mg/mL |
S2510 | Spectinomycin 2HCl | 81 mg/mL | 81 mg/mL | <1 mg/mL |
S1768 | Cefditoren Pivoxil | <1 mg/mL | 100 mg/mL | <1 mg/mL |
S1839 | Chloroxine | <1 mg/mL | 43 mg/mL | <1 mg/mL |
S2264 | Artemether | <1 mg/mL | 60 mg/mL | 60 mg/mL |
S1666 | Flucytosine | 5 mg/mL | 8 mg/mL | <1 mg/mL |
S1998 | D-Cycloserine | 20 mg/mL | <1 mg/mL | <1 mg/mL |
S2479 | Lincomycin HCl | 89 mg/mL | 89 mg/mL | <1 mg/mL |
S1605 | Cefdinir | <1 mg/mL | 79 mg/mL | <1 mg/mL |
S3073 | Caspofungin Acetate | 100 mg/mL | -1 mg/mL | -1 mg/mL |
S2528 | Ciclopirox | <1 mg/mL | 42 mg/mL | 42 mg/mL |
S2152 | Sitafloxacin Hydrate | <1 mg/mL | 4 mg/mL | <1 mg/mL |
S1502 | Cephalexin | 10 mg/mL | 1 mg/mL | <1 mg/mL |
S1835 | Azithromycin | <1 mg/mL | 100 mg/mL | 100 mg/mL |
S1773 | Oxytetracycline (Terramycin) | <1 mg/mL | 92 mg/mL | 10 mg/mL |
S1637 | Docosanol | <1 mg/mL | <1 mg/mL | 4 mg/mL |
S2535 | Econazole nitrate | <1 mg/mL | 89 mg/mL | 5 mg/mL |
S2568 | Neomycin sulfate | 143 mg/mL | <1 mg/mL | <1 mg/mL |
S1777 | Ethionamide | <1 mg/mL | 33 mg/mL | 17 mg/mL |
S1635 | Erythromycin | 3 mg/mL | 147 mg/mL | 147 mg/mL |
S2420 | Aloperine | 12 mg/mL | 2 mg/mL | 46 mg/mL |
S4226 | Minocycline HCl | 1 mg/mL | <1 mg/mL | <1 mg/mL |
S2486 | Moroxydine HCl | 42 mg/mL | 42 mg/mL | <1 mg/mL |
S1644 | Nitrofural | <1 mg/mL | 40 mg/mL | <1 mg/mL |
S3079 | Atovaquone | <1 mg/mL | 5 mg/mL | <1 mg/mL |
S4050 | Valganciclovir HCl | 78 mg/mL | 78 mg/mL | <1 mg/mL |
S4052 | Netilmicin Sulfate | 288 mg/mL | <1 mg/mL | <1 mg/mL |
S4082 | Spiramycin | <1 mg/mL | 100 mg/mL | 100 mg/mL |
S2565 | Amoxicillin Sodium | 78 mg/mL | 78 mg/mL | <1 mg/mL |
S2544 | Cefprozil hydrate | <1 mg/mL | <1 mg/mL | <1 mg/mL |
S2563 | Oxacillin sodium monohydrate | 88 mg/mL | <1 mg/mL | <1 mg/mL |
S3129 | Trimethoprim | <1 mg/mL | 58 mg/mL | <1 mg/mL |
S2028 | Diclazuril | <1 mg/mL | 16 mg/mL | <1 mg/mL |
S3161 | Sertaconazole nitrate | <1 mg/mL | 100 mg/mL | <1 mg/mL |
S1499 | Cefaclor | <1 mg/mL | 11 mg/mL | <1 mg/mL |
S1915 | Sulfamethoxazole | <1 mg/mL | 51 mg/mL | 23 mg/mL |
S2120 | Arbidol HCl | <1 mg/mL | 103 mg/mL | 22 mg/mL |
S2467 | Famciclovir | 64 mg/mL | 64 mg/mL | 48 mg/mL |
S2031 | Fenticonazole Nitrate | <1 mg/mL | 104 mg/mL | 2 mg/mL |
S2574 | Tetracycline HCl | 96 mg/mL | 96 mg/mL | <1 mg/mL |
S2575 | Vancomycin HCl | 100 mg/mL | <1 mg/mL | <1 mg/mL |
S1851 | Oxibendazole | <1 mg/mL | 1 mg/mL | <1 mg/mL |
S2501 | Pyrantel Pamoate | <1 mg/mL | 100 mg/mL | <1 mg/mL |
S4030 | Gentamicin Sulfate | 100 mg/mL | <1 mg/mL | <1 mg/mL |
S2514 | Tobramycin | 94 mg/mL | <1 mg/mL | <1 mg/mL |
S1762 | Pyrazinamide | 12 mg/mL | 25 mg/mL | 2 mg/mL |
S1676 | Amorolfine HCl | 9 mg/mL | 28 mg/mL | 71 mg/mL |
S4075 | Zinc Pyrithione | <1 mg/mL | 30 mg/mL | <1 mg/mL |
S2530 | 7-Aminocephalosporanic acid | <1 mg/mL | 1 mg/mL | <1 mg/mL |
S2536 | Miconazole | <1 mg/mL | 83 mg/mL | 83 mg/mL |
S2543 | Ceftiofur HCl | <1 mg/mL | 100 mg/mL | 22 mg/mL |
S1691 | Praziquantel | <1 mg/mL | 63 mg/mL | 63 mg/mL |
S4237 | Primaquine Diphosphate | 91 mg/mL | 91 mg/mL | <1 mg/mL |
S1964 | Rimantadine | 33 mg/mL | 33 mg/mL | 33 mg/mL |
S1883 | Idoxuridine | <1 mg/mL | 35 mg/mL | <1 mg/mL |
S3162 | Tylosin tartrate | 200 mg/mL | 300 mg/mL | 300 mg/mL |
S1916 | Sulfisoxazole | <1 mg/mL | 53 mg/mL | 2 mg/mL |
S1770 | Sulfadiazine | <1 mg/mL | 50 mg/mL | <1 mg/mL |
S3195 | Azlocillin sodium salt | 97 mg/mL | 97 mg/mL | 3 mg/mL |
S4004 | Ethambutol 2HCl | 56 mg/mL | 56 mg/mL | <1 mg/mL |
S2469 | Fleroxacin | <1 mg/mL | <1 mg/mL | <1 mg/mL |
S3116 | Sulfathiazole | <1 mg/mL | 51 mg/mL | <1 mg/mL |
S1910 | Tioconazole | <1 mg/mL | 78 mg/mL | 78 mg/mL |
S2506 | Roxithromycin | <1 mg/mL | 167 mg/mL | 167 mg/mL |
S2048 | Clindamycin Phosphate | 101 mg/mL | <1 mg/mL | <1 mg/mL |
S3055 | Besifloxacin HCl | 1 mg/mL | <1 mg/mL | <1 mg/mL |
S4120 | Sulconazole Nitrate | <1 mg/mL | 92 mg/mL | <1 mg/mL |
S2511 | Sulfadoxine | <1 mg/mL | 62 mg/mL | <1 mg/mL |
S3067 | Chlorhexidine 2HCl | <1 mg/mL | 100 mg/mL | <1 mg/mL |
S3059 | Enrofloxacin | <1 mg/mL | 3 mg/mL | <1 mg/mL |
S4141 | Dinitolmide | <1 mg/mL | 45 mg/mL | 1 mg/mL |
S1977 | Sarafloxacin HCl | <1 mg/mL | 4 mg/mL | <1 mg/mL |
S4146 | Bacitracin | 100 mg/mL | -1 mg/mL | -1 mg/mL |
S4147 | Azithromycin Dihydrate | 10 mg/mL | 100 mg/mL | 100 mg/mL |
S4254 | Apramycin Sulfate | 100 mg/mL | <1 mg/mL | '<1 mg/mL |
S4056 | Retapamulin | <1 mg/mL | 104 mg/mL | 104 mg/mL |
S3015 | Amoxicillin | <1 mg/mL | 73 mg/mL | <1 mg/mL |
S4184 | Penciclovir | 1 mg/mL | 34 mg/mL | <1 mg/mL |
S4191 | Betamipron | <1 mg/mL | 39 mg/mL | 39 mg/mL |
S1957 | Sulfamethizole | <1 mg/mL | 54 mg/mL | 10 mg/mL |
S2537 | Secnidazole | 37 mg/mL | 37 mg/mL | 37 mg/mL |
S4195 | Broxyquinoline | <1 mg/mL | 17 mg/mL | <1 mg/mL |
S4196 | Ethacridine lactate monohydrate | 5 mg/mL | 72 mg/mL | <1 mg/mL |
S4093 | Bismuth Subcitrate Potassium | 100 mg/mL | <1 mg/mL | <1 mg/mL |
S4094 | Tetramisole HCl | 41 mg/mL | <1 mg/mL | <1 mg/mL |
S2539 | Lomefloxacin HCl | 6 mg/mL | 1 mg/mL | <1 mg/mL |
S2612 | Ribitol | 30 mg/mL | 30 mg/mL | <1 mg/mL |
S3122 | Amikacin hydrate | 100 mg/mL | <1 mg/mL | <1 mg/mL |
S3105 | Nadifloxacin | <1 mg/mL | 20 mg/mL | <1 mg/mL |
S4234 | Capreomycin Sulfate | 100 mg/mL | <1 mg/mL | <1 mg/mL |
S3133 | Sulfamethazine | <1 mg/mL | 56 mg/mL | <1 mg/mL |
S1855 | Pefloxacin Mesylate | 67 mg/mL | 14 mg/mL | <1 mg/mL |
S3154 | Butenafine HCl | <1 mg/mL | 70 mg/mL | 70 mg/mL |
S3156 | Naftifine HCl | <1 mg/mL | <1 mg/mL | 8 mg/mL |
S1833 | Butoconazole nitrate | <1 mg/mL | 95 mg/mL | <1 mg/mL |
S3179 | Carbenicillin disodium | 84 mg/mL | 5 mg/mL | <1 mg/mL |
S3193 | Ticarcillin sodium | 86 mg/mL | 86 mg/mL | <1 mg/mL |
S1881 | Protionamide | <1 mg/mL | 36 mg/mL | 7 mg/mL |
S1830 | Oxfendazole | <1 mg/mL | 10 mg/mL | <1 mg/mL |
S4726 | Lauric Acid | 20 mg/mL | 40 mg/mL | 40 mg/mL |
S5227 | Erythromycin thiocyanate | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S3941 | Pinocembrin | <1 mg/mL | 51 mg/mL | 51 mg/mL |
S5352 | Cefminox Sodium | 100 mg/mL | 100 mg/mL | '<1 mg/mL |
S6235 | Sodium dehydroacetate | -1 mg/mL | 38 mg/mL | -1 mg/mL |
S8071 | UNC0638 | 6 mg/mL | 100 mg/mL | 100 mg/mL |
S3621 | Pazufloxacin mesylate | 82 mg/mL | 82 mg/mL | '7 mg/mL |
S5560 | Midecamycin | <1 mg/mL | 100 mg/mL | 100 mg/mL |
S3999 | α-santonin | -1 mg/mL | 49 mg/mL | -1 mg/mL |
S5406 | Sultamicillin Tosylate | 9 mg/mL | 100 mg/mL | 100 mg/mL |
S5048 | Fosfomycin Disodium | 36 mg/mL | <1 mg/mL | -1 mg/mL |
S9200 | Pneumocandin B0 | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S5051 | Pipemidic acid | 60 mg/mL | <1 mg/mL | '-1 mg/mL |
S5328 | Gamithromycin | <1 mg/mL | 100 mg/mL | '100 mg/mL |
S4576 | Sulfabenzamide | <1 mg/mL | 55 mg/mL | <1 mg/mL |
S5353 | Cefpiramide sodium | 100 mg/mL | 100 mg/mL | <1 mg/mL |
S4848 | Dalbavancin | 100 mg/mL | 100 mg/mL | '<1 mg/mL |
S5081 | Ceforanide | -1 mg/mL | 6 mg/mL | -1 mg/mL |
S5951 | Cefoxitin | <1 mg/mL | 85 mg/mL | 85 mg/mL |
S5035 | 6-Aminopenicillanic acid | <1 mg/mL | 1 mg/mL | <1 mg/mL |
S5356 | Ceftiofur | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S9564 | p-Hydroxy-cinnamic Acid | <1 mg/mL | 33 mg/mL | 33 mg/mL |
S5012 | Octenidine Dihydrochloride | -1 mg/mL | 60 mg/mL | -1 mg/mL |
S2583 | Thiamphenicol | <1 mg/mL | 71 mg/mL | <1 mg/mL |
S3623 | Ceftibuten dihydrate | -1 mg/mL | 90 mg/mL | -1 mg/mL |
S6288 | Chlorhexidine diacetate | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S4850 | Flucloxacillin sodium | 95 mg/mL | 95 mg/mL | 5 mg/mL |
S9224 | Dehydroandrographolide Succinate | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S5944 | Butenafine | <1 mg/mL | 63 mg/mL | 63 mg/mL |
S4846 | Meropenem Trihydrate | 87 mg/mL | 87 mg/mL | 4 mg/mL |
S5533 | Tobramycin sulfate | 100 mg/mL | <1 mg/mL | -1 mg/mL |
S9226 | Steviolbioside | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S4594 | Cephalothin | 83 mg/mL | 10 mg/mL | '<1 mg/mL |
S4865 | Cefetamet pivoxil hydrochloride | <1 mg/mL | 100 mg/mL | 100 mg/mL |
S5359 | Butoconazole | -1 mg/mL | 82 mg/mL | -1 mg/mL |
S5941 | Besifloxacin | <1 mg/mL | <1 mg/mL | <1 mg/mL |
S4866 | Nicarbazin | <1 mg/mL | 9 mg/mL | <1 mg/mL |
S5366 | Fipronil | -1 mg/mL | 87 mg/mL | -1 mg/mL |
S4420 | Mefloquine HCl | <1 mg/mL | 82 mg/mL | 82 mg/mL |
S3966 | Nifuratel | <1 mg/mL | 57 mg/mL | <1 mg/mL |
S4880 | Cefathiamidine | -1 mg/mL | 94 mg/mL | -1 mg/mL |
S5531 | Doripenem | -1 mg/mL | 60 mg/mL | -1 mg/mL |
S3971 | Fusidine | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S1617 | Sulfapyridine | <1 mg/mL | 2 mg/mL | <1 mg/mL |
S5332 | Cefquinome sulfate | 9 mg/mL | 100 mg/mL | <1 mg/mL |
S5278 | Tedizolid (TR-700) | -1 mg/mL | 10 mg/mL | -1 mg/mL |
S4029 | Colistin Sulfate | 100 mg/mL | <1 mg/mL | <1 mg/mL |
S4122 | Tilmicosin | 8 mg/mL | 100 mg/mL | <1 mg/mL |
S2052 | Oxytetracycline Dihydrate | <1 mg/mL | 5 mg/mL | <1 mg/mL |
S5532 | Erythromycin estolate | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S5535 | Moxifloxacin | -1 mg/mL | 24 mg/mL | -1 mg/mL |
S5684 | Lapachol | -1 mg/mL | 48 mg/mL | -1 mg/mL |
S4876 | Robenidine Hydrochloride | -1 mg/mL | 74 mg/mL | -1 mg/mL |
S5625 | Ammonium lactate | ' mg/mL | ||
S4869 | Sulfamethoxazole sodium | -1 mg/mL | 55 mg/mL | -1 mg/mL |
S5719 | Ceftizoxime sodium | 81 mg/mL | 81 mg/mL | <1 mg/mL |
S2058 | Tolnaftate | <1 mg/mL | 62 mg/mL | <1 mg/mL |
S5054 | Rifamycin sodium salt | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S4584 | Butylparaben | 38 mg/mL | 38 mg/mL | 38 mg/mL |
S5207 | Cephalexin Monohydrate | <1 mg/mL | 0.01 mg/mL | <1 mg/mL |
S4585 | Succinylsulfathiazole | <1 mg/mL | 71 mg/mL | '<1 mg/mL |
S5491 | Lomefloxacin | -1 mg/mL | 7 mg/mL | -1 mg/mL |
S4142 | Clopidol | <1 mg/mL | 1 mg/mL | <1 mg/mL |
S4592 | Captisol (SBE-β-CD) | 100 mg/mL | <1 mg/mL | <1 mg/mL |
S5331 | Ceftezole sodium | 92 mg/mL | 92 mg/mL | <1 mg/mL |
S4595 | Cefazolin Sodium | 95 mg/mL | 95 mg/mL | '<1 mg/mL |
S5333 | Sulbenicillin Sodium | 91 mg/mL | 91 mg/mL | '<1 mg/mL |
S5936 | Cefazolin | <1 mg/mL | 91 mg/mL | <1 mg/mL |
S4145 | Decoquinate | <1 mg/mL | 0.01 mg/mL | <1 mg/mL |
S4596 | Cefixime | <1 mg/mL | 90 mg/mL | 1 mg/mL |
S5700 | Phthalylsulfathiazole | -1 mg/mL | 80 mg/mL | '-1 mg/mL |
S4148 | Ampicillin Trihydrate | 2 mg/mL | 81 mg/mL | <1 mg/mL |
S4996 | Tavaborole (AN-2690) | <1 mg/mL | 30 mg/mL | 30 mg/mL |
S2259 | Aloe-emodin | <1 mg/mL | 3 mg/mL | <1 mg/mL |
S4041 | Olsalazine Sodium | 41 mg/mL | 4 mg/mL | <1 mg/mL |
S4150 | Orbifloxacin | <1 mg/mL | 0.05 mg/mL | <1 mg/mL |
S4875 | Cephapirin Benzathine | -1 mg/mL | 81 mg/mL | -1 mg/mL |
S4421 | Josamycin | ' mg/mL | ||
S4885 | Taurolidine | -1 mg/mL | 56 mg/mL | -1 mg/mL |
S4250 | Sulfamethoxypyridazine | <1 mg/mL | 56 mg/mL | '<1 mg/mL |
S9278 | Saikosaponin C | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S5397 | Chlorhexidine | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S4156 | Chlortetracycline HCl | 1 mg/mL | 5 mg/mL | <1 mg/mL |
S4158 | Ceftriaxone disodium salt hemi (heptahydrate) | 100 mg/mL | 1 mg/mL | <1 mg/mL |
S4160 | Penicillin G Sodium | 71 mg/mL | 71 mg/mL | <1 mg/mL |
S2271 | Berberine chloride | <1 mg/mL | 40 mg/mL | <1 mg/mL |
S4942 | 4-Hydroxy-3,5-dimethoxybenzyl alcohol | -1 mg/mL | 36 mg/mL | '-1 mg/mL |
S5492 | Econazole | -1 mg/mL | 76 mg/mL | -1 mg/mL |
S4874 | Cefazedone | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S2282 | Cinchonidine | <1 mg/mL | 59 mg/mL | 59 mg/mL |
S5475 | Novaluron | -1 mg/mL | 99 mg/mL | '-1 mg/mL |
S9292 | Dictamnine | -1 mg/mL | 33 mg/mL | -1 mg/mL |
S5296 | Cephradine monohydrate | 4 mg/mL | <1 mg/mL | -1 mg/mL |
S5290 | Ormetoprim | <1 mg/mL | 0.01 mg/mL | <1 mg/mL |
S5487 | Cefoperazone sodium | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S4610 | Mebendazole | <1 mg/mL | 6 mg/mL | <1 mg/mL |
S4822 | Silver Sulfadiazine | <1 mg/mL | 0.1 mg/mL | <1 mg/mL |
S5294 | Cephalotin acid | -1 mg/mL | 79 mg/mL | -1 mg/mL |
S5736 | Benzathine penicilline | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S4167 | Cyromazine | 1 mg/mL | 33 mg/mL | 2 mg/mL |
S4612 | Dapson | <1 mg/mL | 49 mg/mL | '10 mg/mL |
S1884 | Sparfloxacin | <1 mg/mL | 9 mg/mL | <1 mg/mL |
S5722 | Oxantel Pamoate | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S1395 | Polymyxin B sulphate | 100 mg/mL | <1 mg/mL | <1 mg/mL |
S2385 | Hordenine | <1 mg/mL | 33 mg/mL | 33 mg/mL |
S4634 | Sodium sulfadiazine | 54 mg/mL | 9 mg/mL | '<1 mg/mL |
S4959 | Skatole | -1 mg/mL | 26 mg/mL | -1 mg/mL |
S5601 | Balofloxacin Dihydrate | <1 mg/mL | 2 mg/mL | 2 mg/mL |
S4172 | Cetylpyridinium Chloride | 68 mg/mL | 68 mg/mL | 68 mg/mL |
S4641 | Tedizolid Phosphate | <1 mg/mL | 22 mg/mL | <1 mg/mL |
S6243 | Ethyl pyruvate | ' mg/mL | ||
S3695 | Cystamine dihydrochloride | 45 mg/mL | 14 mg/mL | '2 mg/mL |
S5291 | sulfaisodimidine | -1 mg/mL | 55 mg/mL | -1 mg/mL |
S4175 | Sulfaguanidine | <1 mg/mL | 43 mg/mL | <1 mg/mL |
S2395 | Rheochrysidin | <1 mg/mL | 1 mg/mL | <1 mg/mL |
S3787 | Picroside I | -1 mg/mL | 98 mg/mL | -1 mg/mL |
S3645 | Kitasamycin | <1 mg/mL | 100 mg/mL | '100 mg/mL |
S6562 | KKL-35 | <1 mg/mL | 32 mg/mL | <1 mg/mL |
S4178 | Climbazole | <1 mg/mL | 59 mg/mL | 59 mg/mL |
S3644 | Sulfamonomethoxine | <1 mg/mL | 56 mg/mL | 4 mg/mL |
S9016 | Dipsacoside B | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S3646 | Thimerosal | 80 mg/mL | 80 mg/mL | '20 mg/mL |
S5298 | Amoxicillin trihydrate | -1 mg/mL | 30 mg/mL | -1 mg/mL |
S5546 | Sulfacetamide | -1 mg/mL | 43 mg/mL | -1 mg/mL |
S5908 | Garenoxacin | <1 mg/mL | 2 mg/mL | <1 mg/mL |
S4179 | Mezlocillin Sodium | 100 mg/mL | 100 mg/mL | <1 mg/mL |
S4060 | Erythromycin Ethylsuccinate | <1 mg/mL | 172 mg/mL | 172 mg/mL |
S5515 | Penicillin G Procaine | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S3649 | Ceftazidime | 100 mg/mL | 4 mg/mL | <1 mg/mL |
S5289 | Ceftezole | -1 mg/mL | 88 mg/mL | '-1 mg/mL |
S4062 | Ronidazole | <1 mg/mL | 40 mg/mL | <1 mg/mL |
S4183 | Paromomycin Sulfate | 100 mg/mL | <1 mg/mL | <1 mg/mL |
S3655 | Cefepime Dihydrochloride Monohydrate | 1 mg/mL | 100 mg/mL | <1 mg/mL |
S5020 | Tilorone dihydrochloride | 96 mg/mL | 43 mg/mL | 96 mg/mL |
S5637 | Cefotiam Hexetil Hydrochloride | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S4541 | Triclosan | <1 mg/mL | 57 mg/mL | 57 mg/mL |
S4971 | Buparvaquone | <1 mg/mL | 65 mg/mL | '4 mg/mL |
S5638 | Cefozopran hydrochloride | -1 mg/mL | 100 mg/mL | ''''-1 mg/mL |
S4187 | Salicylanilide | <1 mg/mL | 43 mg/mL | 18 mg/mL |
S5299 | Tosufloxacin p-Toluenesulfonate Hydrate | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S5644 | Ceftriaxone Sodium | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S4720 | Cefotaxime | <1 mg/mL | 91 mg/mL | <1 mg/mL |
S4898 | Sulfalozine sodium | -1 mg/mL | 56 mg/mL | -1 mg/mL |
S5295 | Lincomycin Hydrochloride Monohydrate | -1 mg/mL | 92 mg/mL | -1 mg/mL |
S8871 | Omadacycline tosylate | 100 mg/mL | 100 mg/mL | 100 mg/mL |
S4068 | Tinidazole | <1 mg/mL | 49 mg/mL | <1 mg/mL |
S3676 | Carbendazim | <1 mg/mL | 17 mg/mL | <1 mg/mL |
S2315 | Kanamycin sulfate | 52 mg/mL | <1 mg/mL | <1 mg/mL |
S4192 | Chlorquinaldol | <1 mg/mL | 46 mg/mL | 6 mg/mL |
S4258 | Luliconazole | <1 mg/mL | 71 mg/mL | 5 mg/mL |
S5420 | Clindamycin alcoholate | -1 mg/mL | 95 mg/mL | -1 mg/mL |
S5816 | pyrvinium | <1 mg/mL | 22 mg/mL | <1 mg/mL |
S4882 | Resorantel | -1 mg/mL | 61 mg/mL | -1 mg/mL |
S5421 | Fluoroquinolonic Acid | -1 mg/mL | 25 mg/mL | '-1 mg/mL |
S5292 | Diazolidinyl urea | -1 mg/mL | 55 mg/mL | -1 mg/mL |
S6423 | Tildipirosin | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S4750 | Sulfacetamide sodium salt hydrate | 50 mg/mL | 50 mg/mL | 2 mg/mL |
S5017 | Oxyclozanide | -1 mg/mL | 80 mg/mL | '-1 mg/mL |
S9046 | Berberine | 1 mg/mL | 45 mg/mL | 5 mg/mL |
S6582 | Ozenoxacin | <1 mg/mL | 5 mg/mL | <1 mg/mL |
S8627 | OSS_128167 | <1 mg/mL | 73 mg/mL | <1 mg/mL |
S4870 | Cefodizime Sodium | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S9057 | Sinigrin | -1 mg/mL | 79 mg/mL | -1 mg/mL |
S5887 | Khellin | <1 mg/mL | 26 mg/mL | 7 mg/mL |
S4081 | Sulfacetamide Sodium | 51 mg/mL | 19 mg/mL | <1 mg/mL |
S3636 | Cefadroxil hydrate | 1 mg/mL | 7 mg/mL | <1 mg/mL |
S3637 | Cefpirome sulfate | 100 mg/mL | 100 mg/mL | <1 mg/mL |
S4759 | p-Coumaric Acid | <1 mg/mL | 32 mg/mL | '32 mg/mL |
S3638 | Cefamandole nafate | 100 mg/mL | 100 mg/mL | <1 mg/mL |
S5440 | Berberine Sulfate | -1 mg/mL | 20 mg/mL | -1 mg/mL |
S5948 | Amodiaquine | <1 mg/mL | 71 mg/mL | 22 mg/mL |
S5016 | Isoprinosine | 100 mg/mL | 100 mg/mL | 2 mg/mL |
S2534 | Isoconazole nitrate | <1 mg/mL | 41 mg/mL | 4 mg/mL |
S4978 | Azathramycin | <1 mg/mL | 50 mg/mL | '100 mg/mL |
S3713 | Moxidectin | <1 mg/mL | 100 mg/mL | '100 mg/mL |
S7411 | Ascomycin (FK520) | <1 mg/mL | 100 mg/mL | 100 mg/mL |
S1450 | Nanchangmycin | <1 mg/mL | 100 mg/mL | 100 mg/mL |
S5784 | Vancomycin | <1 mg/mL | 29 mg/mL | <1 mg/mL |
S3705 | Chlorobutanol | <1 mg/mL | 35 mg/mL | '35 mg/mL |
S9387 | Maackiain | -1 mg/mL | 56 mg/mL | -1 mg/mL |
S3707 | Ethopabate | <1 mg/mL | 47 mg/mL | '47 mg/mL |
S3708 | Sulfachloropyridazine | <1 mg/mL | 56 mg/mL | 9 mg/mL |
S4201 | Florfenicol | <1 mg/mL | 72 mg/mL | 8 mg/mL |
S4663 | Fusidate Sodium | 100 mg/mL | 100 mg/mL | 100 mg/mL |
S3709 | Furagin | <1 mg/mL | 52 mg/mL | '<1 mg/mL |
S5041 | Difloxacin hydrochloride | 98 mg/mL | 98 mg/mL | 98 mg/mL |
S4203 | Furaltadone HCl | 72 mg/mL | 17 mg/mL | <1 mg/mL |
S5657 | Ertapenem sodium | 100 mg/mL | 100 mg/mL | <1 mg/mL |
S9078 | Epigoitrin | -1 mg/mL | 4.89 mg/mL | -1 mg/mL |
S4986 | Latamoxef sodium | 100 mg/mL | 100 mg/mL | '<1 mg/mL |
S5033 | Terconazole | <1 mg/mL | 49 mg/mL | '100 mg/mL |
S9084 | Rhoifolin | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S6411 | Nimorazole | -1 mg/mL | 45 mg/mL | -1 mg/mL |
S3058 | Danofloxacin Mesylate | 91 mg/mL | <1 mg/mL | <1 mg/mL |
S4271 | Isepamicin Sulphate | 100 mg/mL | <1 mg/mL | <1 mg/mL |
S3672 | Cefonicid sodium | 100 mg/mL | 100 mg/mL | ''<1 mg/mL |
S4213 | Dirithromycin | <1 mg/mL | 11 mg/mL | 100 mg/mL |
S6729 | Besifovir | 60 mg/mL | 60 mg/mL | 2 mg/mL |
S4215 | Ribostamycin Sulfate | 100 mg/mL | <1 mg/mL | <1 mg/mL |
S4216 | Valnemulin HCl | 100 mg/mL | 100 mg/mL | 100 mg/mL |
S5055 | Milbemycin Oxime | <1 mg/mL | 100 mg/mL | 100 mg/mL |
S4671 | Cefradine | 10 mg/mL | <1 mg/mL | <1 mg/mL |
S5070 | Mupirocin calcium | 6 mg/mL | 100 mg/mL | '100 mg/mL |
S6067 | 2,4-dichlorobenzyl alcohol | -1 mg/mL | 35 mg/mL | -1 mg/mL |
S6068 | Doxycycline monohydrate | -1 mg/mL | 47 mg/mL | -1 mg/mL |
S5724 | Dichlorophen | -1 mg/mL | 54 mg/mL | '-1 mg/mL |
S5829 | Monomyristin | <1 mg/mL | 60 mg/mL | 60 mg/mL |
S2334 | Oleanolic Acid | <1 mg/mL | 21 mg/mL | 7 mg/mL |
S9099 | Orientin | -1 mg/mL | 89 mg/mL | -1 mg/mL |
S2335 | Oridonin | <1 mg/mL | 72 mg/mL | 28 mg/mL |
S3801 | Sodium Houttuyfonate | <1 mg/mL | 2 mg/mL | <1 mg/mL |
S5776 | Proflavine | <1 mg/mL | 23 mg/mL | 2 mg/mL |
S6444 | Triclocarban | <1 mg/mL | 63 mg/mL | 5 mg/mL |
S4222 | Piperacillin Sodium | 100 mg/mL | 100 mg/mL | 100 mg/mL |
S4601 | Clioquinol | <1 mg/mL | 61 mg/mL | 1 mg/mL |
S3650 | Penicillin V potassium salt | 77 mg/mL | <1 mg/mL | <1 mg/mL |
S6451 | Salifungin | <1 mg/mL | 65 mg/mL | 5 mg/mL |
S2613 | Clorsulon | <1 mg/mL | 76 mg/mL | 7 mg/mL |
S9328 | 5,6,7-Trimethoxyflavone | -1 mg/mL | 10 mg/mL | -1 mg/mL |
S5065 | Ganciclovir sodium | 55 mg/mL | <1 mg/mL | '-1 mg/mL |
S5036 | Nisin | 6.7 mg/mL | 7 mg/mL | <1 mg/mL |
S6442 | Chlorphenesin | 10 mg/mL | 41 mg/mL | 41 mg/mL |
S3722 | Isavuconazole | <1 mg/mL | 87 mg/mL | 87 mg/mL |
S5541 | Dimetridazole | -1 mg/mL | 28 mg/mL | -1 mg/mL |
S9342 | 1,4-Naphthoquinone | -1 mg/mL | 32 mg/mL | -1 mg/mL |
S2564 | Cloxacillin Sodium | 55 mg/mL | 55 mg/mL | 25 mg/mL |
S3121 | Ornidazole | 2 mg/mL | 44 mg/mL | 44 mg/mL |
S3979 | Zinc Undecylenate | -1 mg/mL | 36 mg/mL | -1 mg/mL |
S9112 | Kaempferitrin | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S5096 | SulfadiMethoxine sodium | -1 mg/mL | 66 mg/mL | '-1 mg/mL |
S9113 | Ononin | -1 mg/mL | 86 mg/mL | -1 mg/mL |
S6464 | Ftaxilide | <1 mg/mL | 54 mg/mL | 13 mg/mL |
S5924 | Olanexidine Hydrochloride semihydrate | <1 mg/mL | 82 mg/mL | 82 mg/mL |
S6459 | Nifurtimox | <1 mg/mL | 57 mg/mL | <1 mg/mL |
S4232 | Nithiamide | <1 mg/mL | 37 mg/mL | <1 mg/mL |
S3618 | Acetylspiramycin (ASPM) | <1 mg/mL | 100 mg/mL | '15 mg/mL |
S9120 | Scutellarein | -1 mg/mL | 57 mg/mL | -1 mg/mL |
S5410 | Chloramphenicol sodium succinate | -1 mg/mL | 89 mg/mL | -1 mg/mL |
S6467 | Fosfluconazole | <1 mg/mL | 19 mg/mL | <1 mg/mL |
S4517 | Cefotaxime sodium | 95 mg/mL | 95 mg/mL | <1 mg/mL |
S9122 | Tectorigenin | -1 mg/mL | 60 mg/mL | -1 mg/mL |
S4518 | Chloroxylenol | <1 mg/mL | 31 mg/mL | 31 mg/mL |
S5209 | Enoxacin Sesquihydrate | -1 mg/mL | 4 mg/mL | '-1 mg/mL |
S3132 | Sulfamerazine | <1 mg/mL | 53 mg/mL | <1 mg/mL |
S4236 | Proflavine Hemisulfate | 22 mg/mL | <1 mg/mL | <1 mg/mL |
S5208 | Ciprofloxacin hydrochloride hydrate | -1 mg/mL | 8 mg/mL | -1 mg/mL |
S5573 | Tilmicosin phosphate | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S3065 | Amikacin disulfate | 10 mg/mL | <1 mg/mL | <1 mg/mL |
S4523 | Dihydrostreptomycin sulfate | 100 mg/mL | <1 mg/mL | <1 mg/mL |
S3746 | Lumefantrine | <1 mg/mL | 13 mg/mL | <1 mg/mL |
S5212 | Imidazolidinyl Urea | -1 mg/mL | 77 mg/mL | '-1 mg/mL |
S5473 | Pivmecillinam hydrochloride | 95 mg/mL | 95 mg/mL | 95 mg/mL |
S9444 | Tomatine | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S4525 | Ethylparaben | <1 mg/mL | 33 mg/mL | '33 mg/mL |
S5210 | Sulfamethazine Sodium Salt | -1 mg/mL | 60 mg/mL | -1 mg/mL |
S4528 | Furazolidone | <1 mg/mL | 45 mg/mL | <1 mg/mL |
S4678 | Povidone iodine | 28 mg/mL | 28 mg/mL | '28 mg/mL |
S5201 | Acetylisovaleryltylosin Tartrate | -1 mg/mL | 100 mg/mL | '-1 mg/mL |
S5206 | Benzylpenicillin potassium | -1 mg/mL | 74 mg/mL | -1 mg/mL |
S9131 | Punicalagin | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S5211 | 4-Aminosalicylic acid | -1 mg/mL | 10 mg/mL | '-1 mg/mL |
S5094 | Maduramycin Ammonium | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S4833 | Cefoxitin sodium | 89 mg/mL | 89 mg/mL | <1 mg/mL |
S4536 | Nitrofurantoin | <1 mg/mL | 47 mg/mL | <1 mg/mL |
S9135 | Artemisic acid | -1 mg/mL | 46 mg/mL | -1 mg/mL |
S5093 | Rafoxanide | -1 mg/mL | 100 mg/mL | '-1 mg/mL |
S9136 | Neochlorogenic acid | -1 mg/mL | 70 mg/mL | -1 mg/mL |
S3170 | Ampicillin sodium | 74 mg/mL | 37 mg/mL | 74 mg/mL |
S5092 | Febantel | -1 mg/mL | 89 mg/mL | -1 mg/mL |
S5350 | Cefpodoxime proxetil | <1 mg/mL | 100 mg/mL | 100 mg/mL |
S4540 | Sisomicin sulfate | 100 mg/mL | <1 mg/mL | <1 mg/mL |
S4878 | Neticonazole Hydrochloride | -1 mg/mL | 67 mg/mL | -1 mg/mL |
S5405 | Propylparaben | <1 mg/mL | 36 mg/mL | 36 mg/mL |
S4242 | Cetrimonium Bromide (CTAB) | 100 mg/mL | 5 mg/mL | 100 mg/mL |
S5095 | Olaquindox | <1 mg/mL | 0.01 mg/mL | '<1 mg/mL |
S5214 | Imidocarb dipropionate | -1 mg/mL | 39 mg/mL | -1 mg/mL |
S6461 | Permethrin | <1 mg/mL | 78 mg/mL | 19 mg/mL |
S3978 | 5-Phenyl-2,4-pentadienoic acid | -1 mg/mL | 6 mg/mL | '-1 mg/mL |
S5159 | Doxycycline | -1 mg/mL | 88 mg/mL | '-1 mg/mL |
S4279 | Demeclocycline HCl | 26 mg/mL | 100 mg/mL | <1 mg/mL |
S5390 | N-(Hytroxymethy)micotinamide | -1 mg/mL | 30 mg/mL | '-1 mg/mL |
S5744 | Spiramycin I | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S4813 | Cefuroxime axetil | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S5373 | Pseudolaric Acid B | <1 mg/mL | 86 mg/mL | 86 mg/mL |
S4393 | Cephapirin Sodium | ' mg/mL | ||
S5354 | Cefteram pivoxil | <1 mg/mL | 0.01 mg/mL | <1 mg/mL |
S4843 | Potassium acetate | -1 mg/mL | 6 mg/mL | -1 mg/mL |
S4550 | Azelaic acid | 37 mg/mL | 37 mg/mL | '37 mg/mL |
S4844 | Cefcapene Pivoxil Hydrochloride | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S5355 | Piperaquine phosphate | 2 mg/mL | <1 mg/mL | -1 mg/mL |
S5351 | Cefmetazole sodium | 98 mg/mL | 98 mg/mL | 1 mg/mL |
S9560 | Anisodamine Hydrobromide | -1 mg/mL | 77 mg/mL | -1 mg/mL |
S3910 | 4',7-Dimethoxyisoflavone | -1 mg/mL | 4 mg/mL | -1 mg/mL |
S5009 | Brivudine | -1 mg/mL | 66 mg/mL | -1 mg/mL |
S4287 | Micafungin Sodium | 100 mg/mL | -1 mg/mL | '-1 mg/mL |
S5005 | Cefotiam hydrochloride | -1 mg/mL | 100 mg/mL | '-1 mg/mL |
S4553 | Bronopol | 39 mg/mL | 39 mg/mL | 39 mg/mL |
S5859 | Sancycline | <1 mg/mL | 83 mg/mL | '<1 mg/mL |
S1962 | Sulphadimethoxine | <1 mg/mL | 62 mg/mL | <1 mg/mL |
S5007 | Delamanid | <1 mg/mL | 100 mg/mL | '2 mg/mL |
S4555 | Carsalam | <1 mg/mL | 32 mg/mL | 2 mg/mL |
S4812 | Ceftizoxime | <1 mg/mL | 76 mg/mL | <1 mg/mL |
S5863 | Metronidazole Benzoate | <1 mg/mL | 55 mg/mL | 13 mg/mL |
S4404 | Pasiniazid | <1 mg/mL | 58 mg/mL | 15 mg/mL |
S4559 | Cloxiquine | <1 mg/mL | 35 mg/mL | '35 mg/mL |
S7896 | Sodium Tauroursodeoxycholate (TUDC) | 100 mg/mL | 100 mg/mL | 71 mg/mL |
S4522 | Dehydroacetic acid | <1 mg/mL | 33 mg/mL | '33 mg/mL |
S5108 | Tylosin | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S4847 | Faropenem Sodium | 61 mg/mL | 12 mg/mL | <1 mg/mL |
S4565 | Diiodohydroxyquinoline | <1 mg/mL | 13 mg/mL | <1 mg/mL |
S4999 | Avermectin B1 | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S9185 | Nitidine Chloride | -1 mg/mL | 11 mg/mL | -1 mg/mL |
S5456 | Isobavachalcone | <1 mg/mL | 64 mg/mL | 64 mg/mL |
Anti-infection製品
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
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S1047 |
Vorinostat (SAHA)Vorinostat (suberoylanilide hydroxamic acid, SAHA, MK0683) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification. |
![]() ![]() Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype). |
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S1009 |
Dactolisib (BEZ235)Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell. Dactolisib induces autophagy and suppresses HIV-1 replication. Phase 2. |
![]() ![]() Three-dimensional responses of MCF7/IGF-1R cells to TAM (1 μM), E2 and IGF-1. Compared to parental MCF7 cells (a), MCF7/IGF-1R cells (b) in three-dimensional (3D) culture formed bigger acini in response to IGF-1 stimulation and displayed significant TAM resistance when treated with TAM (1 μM) + E2 + IGF-1, which was removable by kinase inhibitors BMS-536924, U0126 and BEZ235 (c). Cells (10,000/well) were seeded in 96-well plates. Acini were formed on 100% Matrigel and cultured for 14 days in starving medium containing 2% Matrigel and 5% charcoal/dextran-stripped fetal bovine serum with the treatments as indicated. Concentrations used: TAM (1 μM), E2 (1 nM) and IGF-1 (100 ng/mL). Confocal image original magnification, × 20. Red, rhodamine phalloidin (actin). Blue, Hoechst blue stain. Results are representative of two individual experiments. |
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S1102 |
U0126-EtOHU0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity. |
![]() ![]() Cells were stimulated with TPA (10 nM) for 15 min in the presence of the indicated concentrations of U0126. Samples were collected and analyzed by Western blot to detect phosphorylated p42/p44 MAPK. |
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S5001 |
Tofacitinib (CP-690550) CitrateTofacitinib citrate (CP-690550 citrate) is a novel inhibitor of JAK with IC50 of 1 nM, 20 nM and 112 nM against JAK3, JAK2, and JAK1, respectively. Tofacitinib citrate has anti-infection activity. |
![]() ![]() CP-690550 reduced the severity of ischemic damage. (A) CP-690550 (10 μM) suppressed IL-17 production by cdT cells and activated memory T cells. cdT cells and CD4+ CD44+ memory T cells isolated from C5BL6J mice through flow cytometry were stimulated for 24 h with plate-bound monoclonal antibodies to CD3 (2 ng/ml) and CD28 (1 ng/ml) in the presence or absence of IL-23 (25 ng/ml). IL-17A production and IL-17A expression level were measured by quantitative RT-PCR (a) and ELISA (b). (B) CBF reduction after brain ischemia. (C) Time-dependent changes in neurological score. *p < 0.05. (D) Infarct volume as visualized through TTC staining on day 3 in CP-690550 (CP)- and vehicle-treated mice.
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S3500新 |
Pentosan Polysulfate SodiumPentosan Polysulfate Sodium (PPS, Elmiron) is an orally bioavailable, semi-synthetic medication with anti-inflammatory and pro-chondrogenic properties. Pentosan Polysulfate Sodium also exhibits anti-HIV-1 activity. |
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S3499新 |
MonocaprylinMonocaprylin (2,3-dihydroxypropyl octanoate, Monoctanoin, 1-Octanoyl-rac-glycerol, MC) exhibits an excellent antibacterial activity against Staphylococcus aureus and Escherichia coli. |
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S3496新 |
Lefamulin acetate (Xenleta)Lefamulin acetate (Xenleta, BC-3781 acetate) is a pleuromutilin antibiotic for community-acquired bacterial pneumonia (CABP) treatment. Lefamulin acetate inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome, thus preventing the binding of transfer RNA for peptide transfer. |
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S3356新 |
Phosphonoacetic acidPhosphonoacetic acid (PAA) is an active endogenous metabolite that possesses a restricted potential to block DNA biosynthesis. Phosphonoacetic acid exhibits anti-viral activities. |
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S3380新 |
TecovirimatTecovirimat (Arestvyr, SIGA-246, ST-246, TPOXX) is an antiviral that inhibits the egress of orthopoxviruses by targeting viral p37 protein orthologs. Tecovirimat is developed for the treatment of smallpox infection. |
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S4417新 |
Ceftaroline FosamilCeftaroline fosamil (CX-0903, DSP-5990, PPI-0903, TAK-599, Teflaro, Zinforo) is a cephalosporin with activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). |
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S3226新 |
Dehydroabietic acidDehydroabietic acid (DAA, DHAA), a naturally occurring diterpene resin acid derived from coniferous plants such as Pinus and Picea, displays anti-inflammatory activity via suppression of Src-, Syk-, and TAK1-mediated pathways. |
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S3295新 |
Taxifolin 7-rhamnosideTaxifolin 7-rhamnoside (TR, Taxifolin 7-O-rhamnoside, Taxifolin 7-O-α-L-rhamnoside), a flavonoid isolated from Hypericum japonicum, shows antibacterial activity against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). |
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S3307新 |
Galangin 3-methyl etherGalangin 3-methyl ether (3-O-Methylgalangin, 3-Methylgalangin), isolated from Lychnophora markgravii aerial parts, shows strong antibacterial and antifungal effects. |
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S3308新 |
Caftaric acidCaftaric acid (CA, Caffeoyl tartaric acid) is a natural product that shows anti-oxidant and anti-inflammatory effects. |
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S3220新 |
TrigonellineTrigonelline (Trigenolline) is a plant alkaloid and a major component of coffee and fenugreek with anti-degranulation, anti-diabetic, antioxidant, anti-inflammatory, and neuroprotective effects. Trigonelline inhibits FcεRI-mediated intracellular signaling pathways, such as phosphorylation of PLCγ1, PI3K, and Akt. Trigonelline (Trigenolline) also inhibits the microtubule formation in RBL-2H3 cells. |
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S3261新 |
MyrislignanMyrislignan, a lignan isolated from Myristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan inhibits interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α). Myrislignan significantly inhibits the expressions of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) dose-dependently in LPS-stimulated macrophage cells. Myrislignan inhibits the NF-κB signalling pathway activation. |
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S9669新 |
U18666AU18666A (U18) is an inhibitor of intra-cellular cholesterol transport that inhibits dengue virus entry and replication. |
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S6867新 |
Glyceryl monocaprate (Monocaprin)Monocaprin (Glyceryl caprate) is a 1-monoglyceride of capric acid that has antimicrobial activity against enveloped viruses, certain bacteria, and the yeast Candida albicans. |
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S2764新 |
DTNBDTNB (Ellman’s Reag, Ellmans Reagenz, 5,5′-Dithiobis(2-nitrobenzoic acid), 5,5′-Dithiobis-2-nitrobenzoesäure) is a non-fluorescent probe used to quantify the number or concentration of thiol groups in a sample. DTNB is also an allosteric inhibitor of dengue virus protease (NS2B-NS3pro) and Streptomyces proteases. |
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S6801新 |
AKOS B018304AKOS B018304, an arylalkylidene derivative with polar substitution at para-position, is a potent inhibitor of chikungunya virus with low micro molar activity. |
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S6802新 |
EtosalamideEtosalamide (Ethosalamide) is an anti-inflammatory drug with antipyretic and analgesics properties. |
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S8512新 |
CenicrivirocCenicriviroc (CVC, TAK-652, TBR-652) is a potent, orally active dual inhibitor of CC chemokine receptor 2 (CCR2) and CCR5. Cenicriviroc also inhibits HIV-1 and HIV-2 with potent anti-inflammatory and antiinfective activity. |
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S6845新 |
GRL0617GRL0617 is a potent, selective and competitive noncovalent inhibitor of severe acute respiratory syndrome (SARS-CoV) papain-like protease (PLPro)/deubiquitinase with IC50 of 0.6 μM and Ki of 0.49 μM. GRL0617 inhibits SARS-CoV viral replication in Vero E6 cells with EC50 of 15 microM and has no associated cytotoxicity. |
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S7418新 |
CycloheximideCycloheximide (Actidione, Naramycin A, CHX), an antifungal antibiotic, is an eukaryote protein synthesis inhibitor with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively. Cycloheximide suppresses ferroptosis and inhibits autophagy. |
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S6848新 |
3'-Fluoro-3'-deoxythymidine (Alovudine)3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer. |
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S4307新 |
AuranofinAuranofin (Ridaura, SKF-39162) is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay. Auranofin has anti-cancer activity and can completely inhibit bacterial growth at 1.2 μM. Auranofin is an FDA-approved gold-containing compound used for the treatment of rheumatoid arthritis. |
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S0833新 |
EIDD-1931EIDD-1931 (Beta-d-N4-hydroxycytidine, β-d-N4-hydroxycytidine, NHC) is an active metabolite of EIDD-2801, a promising COVID-19 inhibitor. EIDD-1931 (NHC) has broad spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and related zoonotic group 2b or 2c Bat-CoVs with average IC50 of 0.15 μM, as well as increased potency against a coronavirus bearing resistance mutations to the nucleoside analog inhibitor remdesivir. |
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S8969新 |
Molnupiravir (EIDD-2801)Molnupiravir (EIDD-2801, MK-4482) is an orally bioavailable prodrug of the ribonucleoside analog β-d-N4-hydroxycytidine (NHC; EIDD-1931) with broad-spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and the causative agent of COVID-19. |
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S0515新 |
PLpro inhibitorPLpro inhibitor is a potent papain-like protease (PLpro) inhibitor with IC50 of 2.6 μM. |
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S0433新 |
NucleozinNucleozin is an antivirus agent that targets influenza A nucleoprotein (NP). Nucleozin triggers the aggregation of NP and inhibits its nuclear accumulation. |
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S0436新 |
PleconarilPleconaril (APO-P001, Picovir, VP 63843, WIN 63843) is a capsid inhibitor used previously to treat enterovirus infections. Pleconaril is effective in inhibiting replication with IC50 of < 0.050 μM. |
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S0467新 |
EmodepsideEmodepside (QHT06, BAY 44-4400, PF 1022-221), a semisynthetic derivative of PF1022A, is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity. Emodepside activates Ca-dependent SLO-1-like K channels. |
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S0470新 |
RSV604RSV604 (A-60444), a novel benzodiazepine, is an inhibitor of respiratory syncytial virus (RSV) with EC50 of 0.86 μM. RSV604 has significant potential for the effective treatment of RSV disease. Phase 2. |
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S0491新 |
Manogepix (E1210)Manogepix (E1210, MGX, APX001A) is a broad-spectrum and orally active antifungal agent that inhibits Gwt1/Gwt1p (GPI-anchored wall transfer protein 1), a protein that plays an important role in fungal cell wall integrity. |
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S0285新 |
Bay 41-4109 racemateBAY 41-4109 racemate (BAY41-4109 Racemic) is a mixture of R-isomer of BAY 41-4109 and S-isomer of BAY 41-4109. BAY 41-4109 an antiviral compound that inhibits human hepatitis B virus (HBV) with IC50 of 53 nM. |
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S0289新 |
KIN1148KIN1148 is an agonist of interferon regulatory factor 3 (IRF3) that induces dose-dependent IRF3 nuclear translocation and specific activation of IRF3-responsive promoters. KIN1148 is an influenza vaccine adjuvant that enhances flu vaccine efficacy. |
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S0147新 |
KKL-10KKL-10 is an inhibitor of ribosome rescue that exhibits exceptional broad-spectrum antimicrobial activity against bacteria. |
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S0195新 |
Walrycin BWalrycin B is an antibacterial compound and a potent inhibitor of WalR targeting the WalR response regulator. |
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S6814新 |
GS-441524GS-441524, a molecular precursor to a pharmacologically active nucleoside triphosphate molecule, is a potent inhibitor of feline infectious peritonitis virus (FIPV) with EC50 of 0.78 μM. |
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S5183新 |
PD 169316PD 169316 is a potent, selective and cell-permeable p38 MAP kinase inhibitor with IC50 of 89 nM. PD169316 abrogates signaling initiated by both TGFbeta and Activin A. PD169316 shows antiviral activity against Enterovirus71. |
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S0076新 |
ABX464ABX464 (SPL-464) is a novel anti-HIV molecule that inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs) from 5 different donors with IC50 ranging between 0.1 μM and 0.5 μM. |
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S0038新 |
AB-423AB-423, a member of the sulfamoylbenzamide (SBA) class of hepatitis B virus (HBV) capsid inhibitors, shows potent inhibition of HBV replication with EC50 of 0.08 μM - 0.27 μM and EC90 of 0.33 μM - 1.32 μM in cells. Phase 1. |
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S6689新 |
MerimepodibMerimepodib (Merimempodib, MMPD, VI-21,497, VX-497) is a potent, specific, and reversible inosine monophosphate dehydrogenase(IMPDH) inhibitor with antiviral activity against hepatitis C virus (HCV) and a variety of DNA and RNA viruses in vitro.Merimepodib is an immunosuppressive agent. |
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S6771新 |
MAC-545496MAC-545496 is a nanomolar glycopeptide-resistance-associated protein R(GraR) inhibitor with strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM). MAC-545496 can reverse β-lactam resistance in methicillin-resistant strains and synergize with CAMPs. MAC-545496 shows remarkable activity in macrophages and attenuates S. aureus virulence in a G. mellonella larvae infection model. |
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S8932新 |
Remdesivir (GS-5734)Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV. |
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S6676新 |
EbselenEbselen (DR 3305, SPI-1005, PZ-51) is a small-molecule capsid inhibitor of HIV-1 Replication with IC50 of 46.1 nM in TR-FRET assay. |
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S1230 |
Flavopiridol (Alvocidib)Flavopiridol (Alvocidib, NSC 649890, HMR-1275) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4, CDK6, and CDK9 with IC50 values in the 20-100 nM range. It is more selective for CDK1, 2, 4, 6, 9 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol induces autophagy and ER stress. Flavopiridol blocks HIV-1 replication. Phase 1/2. |
![]() ![]() (C) In vivo treatment of Tg:Pomc-Pttg;Pomc-eGFP embryos with small-molecule CDK inhibitors (50 μM) or 0.2% DMSO as control from 18 to 40 hpf. One hundred to one hundred fifty embryos were treated with each compound. Representative images of live embryos are shown with gross morphology (Right) and pituitary Pomc-GFP-positive cells at higher magnification (Left) at 40 hpf. Embryos exposed to flavopiridol developed early developmental defect before pituitary POMC cell ontogeny occurs. (D) Relative expression of pituitary Pomc-eGFP fluorescence analyzed using Volocity 5.2 software (Improvision; mean ±SE of relative expression, n = 7). (E) R-roscovitine specifically suppresses expansion of pituitary POMC cells overexpressing zPttg from 18 to 48 hpf. Double transgenic Tg:Pomc-Pttg;Prl-RFP embryos were generated by breeding Tg:Pomc-Pttg fish with a previously generated PRL-RFP transgenic line, in which RFP was targeted to pituitary lactotrophs by a zebrafish Prolactin promoter (34). Representative fluorescent microscopy of pituitary POMC-eGFP (a and b) and PRL-RFP (c and d) expression in live Tg:Pomc-Pttg; Pomc-eGFP and Tg:Pomc-Pttg;Prl-RFP embryos treated with 0.2% DMSO (a and c) or 50 μM R-roscovitine (b and d). (F) Relative expression of pituitary POMC-eGFP or PRL-RFP fluorescence were analyzed (mean ±SE of relative expression; n = 10). Results represent one of three similar experiments;*P < 0.02 and **P < 0.000005. (Scale bar, 50 μm.) |
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S2003 |
MaravirocMaraviroc (UK-427857) is a CCR5 antagonist for MIP-1α, MIP-1β and RANTES with IC50 of 3.3 nM, 7.2 nM and 5.2 nM in cell-free assays, respectively. Maraviroc is used in the treatment of HIV infection. |
![]() ![]() CCR5 antagonists block FBS-induced breast cancer cell invasion. 3D reconstruction of FBS-induced invasion into collagen gels by Hs578T (A) or SUM-159 (C) breast cancer cells in presence of CCR5 antagonists (100 nmol/L). The corresponding quantifications (mean ±SEM, n = 3) and analysis (Bonferronit test) are displayed in B and D. |
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S2679 |
Flavopiridol HClFlavopiridol HCl (NSC 649890 HCl, alvocidib, L86-8275, HMR-1275, DSP-2033) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM in cell-free assays. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol HCl induces autophagy and ER stress. Flavopiridol HCl blocks HIV-1 replication. Phase 1/2. |
![]() ![]() Comparative efficacy of anticancer therapies (Flavopiridol, vincristine, daunorubicin, et al.) in NMC vs non-NMC cell lines. Mean IC50 (± s.e.m.) of the indicated agents in three NMC (PER-403, PER-624, and PER-704) and two non-NMC cell lines (PER-535 and SAOS2), ***P<0.001, unpaired t-test, corrected for multiple testing. |
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S2728 |
AG-1478 (Tyrphostin AG-1478)AG-1478 (Tyrphostin AG-1478, NSC 693255) is a selective EGFR inhibitor with IC50 of 3 nM in cell-free assays, almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR. AG-1478 (Tyrphostin AG-1478) inhibits encephalomyocarditis virus (EMCV) and hepatitis c virus (HCV) by targeting phosphatidylinositol 4-kinase IIIα (PI4KA). |
![]() ![]() A549 cells were treated with G15 (a specific antagonist of GPR30, 1 uM), AG1478 (a potent antagonist of EGFR, 10 uM), BPA (10-5 M) alone for 15 min or BPA after a 90-min pretreatment with G15 or AG1478 for 15 min. Then the expression of p-ERK1/2 and total ERK1/2 were measured by western blot analysis.
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S1209 |
Fluorouracil (5-Fluorouracil, 5-FU)Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV. |
![]() ![]() DNA-PKcs suppression mediated ROS production and GSH content in HepG2 cells exposed to CDDP and 5-Fu. a DNA-PKcs inhibition promoted ROS production in HepG2 cells treated with indicated concentrations of CDDP and 5-Fu. DCFH-DA fluorescent analysis was performed to assess the ROS level. Data presented were mean ?SD of three independent experiments.
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S1537 |
DMXAA (Vadimezan)DMXAA (Vadimezan) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-β but relatively low TNF-α expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3. |
![]() ![]() (B and C) sh-scrambled or sh-ck2a–transducted L929 cells (B) and Raw cells (C) were stimulated by DMXAA (100 μg/ml) for various times. Cytosolic and nuclear extracts were prepared as described in Materials and Methods. Five percent of the cytosolic proteins and 20% of the nuclear proteins were resolved by 10% SDS-PAGE. Subsequently, immunoblotting was conducted by indicated Abs. The amounts of Tubulin and Lamin B1 in cytosol versus nuclei detected by respective Abs were used as internal control for fractionation.
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S1117 |
TriciribineTriciribine (NSC 154020, VD-0002, vqd-002, API-2) is a DNA synthesis inhibitor, also inhibits Akt in PC3 cell line and HIV-1 in CEM-SS, H9, H9IIIB, U1 cells with IC50 of 130 nM and 20 nM, respectively; does not inhibit PI3K/PDK1; 5000-fold less active in cells lacking adenosine kinase. Phase 1/2. |
![]() ![]() Effect of triciribine on the migration of (A) FaDu and (B) Hep2 cells. The cells were treated with 5 µM triciribine for different periods of time. *P<0.05 vs. control. Hpf, high-power field. |
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S1516 |
CidofovirCidofovir (HPMPC) suppresses virus replication by selective inhibition of viral DNA synthesis. |
![]() ![]() The copy numbers of the intracellular viral DNA were directly extracted from cells and were quantified by qPCR using primers specific for the KSHV ORF73 gene. Then each sample was normalized to the amount of the GAPDH gene (C), CDV (20 µM) was used as a positive control. CDV:Cidofovir. |
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S1228 |
Idarubicin HClIdarubicin HCl (4-demethoxydaunorubicin, NSC256439, 4-DMDR) is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay. Idarubicin induces mTOR-dependent cytotoxic autophagy. |
![]() ![]() Sensitivity of AML cells to conventional induction treatment and small-molecule p53 activators. Cell viability in OCI-AML3 cells treated for 24 hours with cytarabin/idarubicin (CI) and Nultin-3A (Nut; A), CI and Leptomycin-B (LMB; B), or Nut and LMB (D), respectively. CI was tested at 0, 100, 200, and 300 nmol/L CI; Nutlin-3A at 0, 2.5, 5, 7.5; and LMB at 0, 2, 8, 32 ng/mL in dosages 0, 1, 2, and 3, respectively. Cell viability in normal and AML bone marrow cells. |
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S1442 |
VoriconazoleVoriconazole (UK-109496) is a new triazole derivative similar to fluconazole and itraconazole that acts by inhibiting fungal cytochrome P-450-dependent, 14-alpha-sterol demethylase-mediated synthesis of ergosterol. |
![]() ![]() Voriconazole increases the osteogenic activity of human osteoblasts in vitro. Osteoblasts were exposed to voriconazole (VCZ) or fluconazole (FCZ) at 15 or 200 μg/ml in osteoinductive medium (OS+) for up to 7 days. As a positive control, cells were also exposed to sodium fluoride (NaF) at 10 μM in nonosteoinductive medium (OS−). Osteoblastic differentiation was evaluated by measuring alkaline phosphatase (ALP) activity (A) and staining for calcium deposition with alazarin red S stain (B and C); calcium deposition was quantified by measuring the absorbance (A415) of extracted alazarin red S (B) and was assessed by the light microscopic appearance (white arrows) of stained osteoblast cultures (C). Values represent the means ± SD. *, P < 0.05, compared to osteoblasts grown under osteogenic conditions without treatment. |
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S7046 |
Brefeldin ABrefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis. It could also improve the HDR(homology-directed repair) efficiency and be an enhancer of CRISPR-mediated HDR. Brefeldin A is also an inhibitor of autophagy and mitophagy. |
![]() ![]() Cells were treated with brefeldin A or manumycin A, and the resulting supernatant was collected after 48 h for exosomal preparation (lanes 1 and 2), or exosomes obtained from C81 cells were trypsin-treated or freeze/thawed (F/T) and then trypsin-treated (lanes 3 and 4). Lanes 5 and 6, input exosome controls from C81 or CEM cells, respectively. Resulting exosomes were assayed for the presence of Tax by Western blotting. |
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S1189 |
AprepitantAprepitant (MK-0869, L-754030) is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0.1 nM. Aprepitant reduces levels of pro-inflammatory cytokines including G-CSF, IL-6, IL-8 and TNFα. Aprepitant inhibits HIV infection of human macrophages. |
![]() ![]() HepT1, HepG2, and HuH6 cells were treated with increasing doses of aprepitant or SP [100 nM] and Western blot analysis was performed for the apoptotic markers PARP, Caspase-3, and BID. |
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S2713 |
GeldanamycinGeldanamycin (NSC 122750) is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. Geldanamycin attenuates virus infection-induced ALI (acute lung injury)/ARDS (acute respiratory distress syndrome) by reducing the host's inflammatory responses. |
![]() ![]() Phenotypic effect of Genetic or Pharmacologic Compromise of the 477 Hsp70-StiA-Hsp90 Complex. The impact of each genetic modification on radial growth, conidiation, and response to various stress conditions was assessed after inoculation of a suspension of 104 conidia on glucose minimal medium (GMM) agar plates and incubation at 37ºC for 5 days.
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S1401 |
TenofovirTenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections. |
![]() ![]() The Nucleotide analog reverse-transcriptase inhibitor Tenofovir disoproxil fumarate was added to TZM-bl cells. Cells were inoculated with 0.05 ng mock-exposed and semen-exposed HIV, and 0.5 ng HIV as infectivity-matched control. Infection rates were measured 3 days post infection by measuring β-galactosidase or or 4 days post infection by measuring luciferase activities. The left panels show the mean enzyme activities ± standard deviation derived from triplicate infections. RLU/s: relative light units per second. Middle panels show normalized infection rates in which reporter enzyme activities obtained from infected cells in the absence of inhibitor were set at 100%. The right panels depict the calculated IC50 values. The number above the bar represents the fold-change in the IC50 derived from 0.05 ng semen-exposed relative to 0.05 or 0.5 ng mock-exposed virus infection. Ns, no statistically significant difference; **** p<0.0001; *** p<0.001 (unpaired t-test). |
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S7015 |
BirinapantBirinapant (TL32711) is a SMAC mimetic antagonist, mostly to cIAP1 with Kd of <1 nM in a cell-free assay, less potent to XIAP. Birinapant helps to induce apoptosis in latent HIV-1-infected cells. Phase 2. |
![]() ![]() Western blot analysis of XIAP and cIAP1 expression and PARP cleavage in H460, A549 and 34LU cells pre-treated with vorinostat or entinostat for 6h followed by the SMAC mimetic birinapant for 24h. |
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S1400 |
Tenofovir Disoproxil FumarateTenofovir (GS-1278) Disoproxil Fumarate belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination. |
![]() ![]() Human PBMCs containing indicated concentrations of Tenofovir disoproxil fumarate were inoculated with 5 ng mock-exposed or semen-exposed R5-HIV-luciferase, or 50 ng R5-HIV-luciferase as infectivity matched control. Infection rates were determined 3 days post inoculation.
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S1704 |
EmtricitabineEmtricitabine (FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h. |
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S2597 |
Oseltamivir PhosphateOseltamivir Phosphate is a potent and selective inhibitor of the neuraminidase that is essential for replication of influenza A and B viruses, used to prevent influenza. |
![]() ![]() Nystatin, filipin III, and oseltamivir inhibit the labeling of trophozoites by CTXB and GM1 antibodies. (A) Trophozoites were treated with nystatin (27 μM), filipin III (7.6 μM), and oseltamivir (20 μM) for 30 min before labeling with Alexa Fluor-conjugated CTXB antibody (images a to d) and GM1 antibody (images a′ to d′). Myriocin (27 μM), a sphingolipid inhibitor, was used as a negative control (images e and e′). N, nucleus; PM, plasma membrane; F, flagella; VD, ventral disc. Bars, 5 μm. (B and C) Changes in intensity of control and inhibitor-treated trophozoites. For intensity measurements, cells were randomly selected from 10 to 15 fields from 3 to 5 separate experiments. Approximately 50 cells were considered for each condition and were analyzed using Zeiss Zen 2009 confocal software. One-way ANOVAs were performed to evaluate differences (means ± SDs) between the treatment and control groups. Mean intensities from 3 to 5 separate experiments are shown in panels B and C. Statistical significance was calculated using a one-way ANOVA test, followed by the Tukey (B) and Holm-Šídák (C) methods. *, P < 0.05; **, P < 0.01; ***, P < 0.001; NS, not significant. |
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S3021 |
RimonabantRimonabant (SR141716) is a selective antagonist of CB1 with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane. Rimonabant is also a dual inhibitor of acyl CoA:cholesterol acyltransferases(ACAT) 1 and 2 and inhibits mycobacterial MmpL3. |
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S8030 |
Plerixafor (AMD3100)Plerixafor (AMD3100, JM 3100) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor inhibits human immunodeficiency virus (HIV) replication. |
![]() ![]() BLI of NSG mice engrafted with BV173, treated with no therapy (control), plerixafor: 1 mg/kg IP daily, ESKM 100 ug twice weekly, and a combination of ESKM and plerixafor. (A) Logarithmic plot of BLI of leukemia growth measured weekly. Error bars are 5-95% confidence intervals. There was a small but not significant difference between ESKM and combination treated group. (B) End of therapy (day 34) BLI.
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S1896 |
HydroxyureaHydroxyurea (nci-c04831, nsc32065) is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. Hydroxyurea activates apoptosis and autophagy. Hydroxyurea is used to treat HIV infection. |
![]() ![]() Lethally irradiated C57BL/6 recipient mice were injected with a 1:1 mixture of GFP+JAK2(V671F) and wild-type bone marrow cells. Five weeks later, mice were treated with vehicle (C), hydroxyurea (H; 30 mg/kg twice daily IP), ruxolitinib (R; 30 mg/kg twice daily oral gavage), BMN673 (B; 0.33 mg/kg IV), H+R, H+B, R+B, and H+R+B for 3 weeks. Percentage of GFP+JAK2(V617F) was measured in (panel B) bone marrow cells, (panel C) splenocytes, and (panel D) peripheral blood leukocytes; (panel E) number of GFP+JAK2(V617F) Lin−Sca1+c-Kit+ (LSK) cells per 106 bone marrow cells was calculated, too. *P < .05, **P < .05, and ***P < .05 when compared with control, single treatment, and double treatment, respectively, from 6 to 7 mice using the Student t test.
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S1386 |
Nafamostat MesylateNafamostat mesilate (FUT-175) is a synthetic serine protease inhibitor, used as an anticoagulant during hemodialysis. Nafamostat mesylate blocks activation of SARS-CoV-2 and is investigated as a new treatment option for COVID-19. Nafamostat Mesilate attenuates inflammation and apoptosis. |
![]() ![]() Immunofluorescence of NF-κB/p65 in HCT 116 and SW 1116 cells exposed to TNFα (25 ng/ml) with or without nafamostat mesilate(FLU) (100 μM). Scale bars: 20 μm. |
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S1627 |
NitazoxanideNitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent(IC50 for canine influenza virus ranges from 0.17 to 0.21 μM). Nitazoxanide modulates autophagy and inhibits mTORC1 signaling. |
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S1623 |
Acetylcysteine (N-acetylcysteine)Acetylcysteine (N-acetyl-l-cysteine, NAC) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine(N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine(N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions of Acetylcysteine are best fresh-prepared. |
![]() ![]() (C) Double immunolabeling showed CK-labeled cells (green) co-expressed with 40, 6-diamidino-2-phenylindole (DAPI) (blue), scale bars are 50 μm.
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S1384 |
MizoribineMizoribine (Bredinin, NSC 289637) is an imidazole nucleoside and an immunosuppressant that inhibits HCV RNA replication with IC50 of ~ 100 μM for anti-HCV activity. Mizoribine is a selective inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH) and guanosine monophosphate synthetase. Mizoribine also inhibits SARS-CoV. |
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S8047 |
DynasoreDynasore is a cell-permeable, reversible non-competitive dynamin inhibitor of GTPase activity of dynamin 1/2, with IC50 of 15 μM in a cell-free assay, also inhibits the mitochondrial dynamin Drp1, with no effect against other small GTPase. Dynasore suppresses mTORC1 activity and induces autophagy. Dynasore inhibits the entry of several viruses, including herpes simplex virus (HSV). |
![]() ![]() Immunocytochemistry demonstrates NR4A1 nuclear location at control (non-chymase treated) in HL-1 cells (a). Chymase (2.5 ug/ml) treatment for 2 h induces NR4A1 (red) cytoplasmic translocation in HL-1 cells as well as myosin (green) disruption (panel b). Active chymase enters HL-1 cells and is prevented by Dynasore (c and d). There marked entry into HL-1 cell nuclei and cytoplasm after treatment with chymase (5 ug/ml) for 2 h that is prevented by pre-treatment with Dynasore. Lack of co-staining with caveolin 3 (green) demonstrates that chymase is not transported via caveolae. Dynasore prevents transferrin uptake in HL-1 cells. |
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S1848 |
CurcuminCurcumin (Diferuloylmethane) is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase(IC50~25 μM) and Histone deacetylase (HDAC); activates Nrf2 pathway and supresses the activation of transcription factor NF-κB. Curcumin induces mitophagy, autophagy, apoptosis, and cell cycle arrest with antitumor activity. Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus, hepatitis C virus, HIV and so on. |
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S4157 |
Chloroquine diphosphateChloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Chloroquine is also an inhibitor of toll-like receptors (TLRs). |
![]() ![]() NCI-H929 EV and miR-137 OE cells were treated with ATM activator Chloroquine Phosphate (CQ), specific ATM inhibitor KU-55933, and ATR inhibitor AZ20 for 12 hr. Immunoblotting showed the expression of p-ATM, p-Chk2, p-BRCA1, p-ATR and p-Chk1. |
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S2310 |
HonokiolHonokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Honokiol causes G0/G1 phase arrest, induces apoptosis, and autophagy via the ROS/ERK1/2 signaling pathway. Honokiol inhibits hepatitis C virus (HCV) infection. Phase 3. |
![]() ![]() (B) Cleaved PARP, Bax and Bcl2 protein expression was evaluated by immunoblotting of KRAS mutant cells lysates after 48 h of honokiol (10, 20, 40, and 60 μM) treatment. ∗∗P < 0.01 and ∗∗∗P < 0.001 for comparison between control group and honokiol-treated group. |
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S2239 |
TubacinTubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1. Tubacin reduces the replication of the Japanese Encephalitis Virus via the decrease of viral RNA synthesis. |
![]() ![]() Verification of Hdac6 deletion in knockout MEFs. Expression of HDAC6 and acetylation of tubulin were analyzed by immunoblotting.
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S1351 |
IvermectinIvermectin (MK-933, IVM) is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug. Ivermectin (MK-933, IVM) is a specific positive allosteric effector of P2X4 and α7 nicotinic acetylcholine receptors (nAChRs). Ivermectin has potent antiviral activity towards both HIV-1 and dengue virus. Ivermectin induces autophagy through the AKT/mTOR signaling pathway and mitophagy. |
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S2527 |
Methacycline HClMethacycline HCl (Rondomycin) is a tetracycline antibiotic, and also an inhibitor of epithelial–mesenchymal transition (EMT) with IC50 of roughly 5 μM, used to treat various infections. |
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S1677 |
ChloramphenicolChloramphenicol (Chloromycetin) is a bacteriostatic by inhibiting protein synthesis. |
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S2716 |
Peramivir TrihydratePeramivir Trihydrate (BCX-1812, RWJ-270201, S-021812) is a trihydrate of the anti-infection agent peramivir which is a transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM. |
![]() ![]() Dose-response curve of the SH5190, SH5190 R292K and the A(H1N1)pdm09 (2167) viruses in the presence of peramivir (C) using a chemiluminescent (NA-star) assay. The NA activity of the H7N9 or H1N1 viruses under increasing concentrations (0.03-1000 nM) of the NAIs was determined. Each data point represents the normalized mean ± SEM neuraminidase activity from three replicated wells. The experiments were repeated twice. |
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S1606 |
ClotrimazoleClotrimazole (BAY b 5097, FB 5097) alters the permeability of the fungal cell wall by inhibiting the biosynthesis of ergosterol, used in the treatment of fungal infections. |
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S1956 |
Miconazole NitrateMiconazole (NSC 169434) Nitrate is an imidazole antifungal agent by inhibiting ergosterol biosynthesis and inducing ROS, used to treat vaginal yeast infections. |
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S2557 |
Terbinafine HClTerbinafine HCl (KWD 201) inhibits ergosterol synthesis by inhibiting squalene epoxidase, used as an antifungal drug. |
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S2457 |
Clindamycin HClClindamycin HCl inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections. |
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S1611 |
CefoperazoneCefoperazone is a cephalosporin antibiotic for inhibition of rMrp2-mediated [3H]E217βG uptake with IC50 of 199 μM. |
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S3007 |
ZanamivirZanamivir (GG167) is a neuraminidase inhibitor used in the treatment and prophylaxis of influenza caused by influenza A virus and influenza B virus. |
![]() ![]() Dose-response curve of the SH5190, SH5190 R292K and the A(H1N1)pdm09 (2167) viruses in the presence of oseltamivir zanamivir (B) using a chemiluminescent (NA-star) assay. The NA activity of the H7N9 or H1N1 viruses under increasing concentrations (0.03-1000 nM) of the NAIs was determined. Each data point represents the normalized mean ± SEM neuraminidase activity from three replicated wells. The experiments were repeated twice. |
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S2908 |
Hygromycin BHygromycin B, a selective antibiotic that is effective on most bacteria, fungi and higher eukaryotes, inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S ribosome. |
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S1854 |
BifonazoleBifonazole (Bay h 4502) is a substituted imidazole antifungal agent. |
![]() ![]() Percentage of MBP+ oligodendrocytes generated from OPCs following treatment with azoles (c). n ≥ 4 wells per condition.
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S1876 |
Valaciclovir HClValaciclovir HCl, an aciclovir prodrug, inhibits activity of virus DNA polymerase, used to treat infections caused by herpes simplex virus (HSV) and varicella zoster virus, and for prophylaxis against cytomegalovirus (CMV). |
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S1997 |
LiranaftateLiranaftate is a squalene epoxidase inhibitor with anti-fungicidal activities. |
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S1791 |
Bacitracin ZincBacitracin is an antibiotic that interferes with the dephosphorylation of C55-isoprenyl pyrophosphate, a membrane carrier molecule that transports the building-blocks of the peptidoglycan bacterial cell wall outside of the inner membrane. It inhibits cleavage of Tyr from Met-enkephalin with IC50 of 10 μM. |
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S2572 |
Streptomycin sulfateStreptomycin sulfate is a sulfate salt of streptomycin that is a protein synthesis inhibitor. |
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S1618 |
SulfameterSulfameter is a long-acting sulfonamide antibacterial. |
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S1685 |
SulfanilamideSulfanilamide (Sulphanilamide) is a competitive inhibitor for bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM. |
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S8279 |
ShikoninShikonin (nchusin, Anchusa acid, Alkanna Red, C.I. 75535, Isoarnebin 4, NSC 252844), a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition. |
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S8750 |
NGI-1 (ML414)NGI-1 (ML414) is an aminobenzamide-sulfonamide compound that targets both oligosaccharyltransferase (OST) isoforms and therefore may exhibit antiviral activity against flaviviruses. |
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S5144 |
NeferineNeferine ((R)-1,2-Dimethoxyaporphine), a natural component of Nelumbo nucifera, has antitumor efficiency. Neferine induces apoptosis in renal cancer cells. Neferine prevents autophagy through activation of Akt/mTOR pathway and Nrf2 in muscle cells. Neferine strongly inhibits NF-κB activation. Neferine possesses a number of therapeutic effects such as anti-diabetic, anti-aging, anti-microbial, anti-thrombotic, anti-arrhythmic, anti-inflammatory and even anti-HIV. |
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S2830 |
ClindamycinClindamycin inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections. |
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S7311 |
Q-VD-OphQ-VD-Oph is a potent pan-caspase inhibitor with IC50 ranged from 25 to 400 nM for caspases 1,3,8, and 9. Q-VD-OPh can inhibits HIV infection. |
![]() ![]() UA and Q-VD-Oph attenuated TNF-α-induced unclear translocation of NF-κB (C) and P-STAT3(S727) (D) in BEAS-2B cells.
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S5554 |
Lanatoside CLanatoside C is a cardiac glycoside with antiviral and anti-tumor activity. Lanatoside C induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways. |
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S5268 |
SolithromycinSolithromycin (CEM-101, OP-1068), belonging to the well-known class of macrolide antibiotics that also includes azithromycin, is a potent bacterial protein synthesis inhibitor. |
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S4970 |
NerolNerol (Cis-Geraniol, Neryl alcohol) is a monoterpene found in many essential oils such as lemongrass and hops. |
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S7975 |
Favipiravir (T-705)Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections. |
![]() ![]() (A) BoDV-1 infection was measured by IFA. BoDV-1 P40 was detected with a primary monoclonal antibody (red), nuclei were stained with DAPI (blue), merged image (scale bars: 50 μm). Favipiravir: T-705
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S4941 |
FarnesolFarnesol is a natural sesquiterpene alcohol that is potent in treating antimetabolic disorders, anti-inflammation, showing antioxidant, anticancer, and antibiotic effects. |
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S7550 |
Erythromycin CyclocarbonateErythromycin Cyclocarbonate, derivative of Erythromycin, inhibits protein synthesis of bacteria by binding to the 50S ribosome. |
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S4599 |
Benzyl benzoateBenzyl benzoate (Ascabiol, Novoscabin, Scabitox, Benzoic acid benzyl ester) is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. |
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S7784 |
FumagillinFumagillin is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to treat microsporidiosis. |
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S4861 |
OxindoleOxindole (2-indolone, 2-Oxindole, Indolin-2-one) is an aromatic heterocyclic organic compound which causes sedation, muscle weakness, hypotension, and coma when dosed in excess. |
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S8873 |
Letermovir (AIC246)Letermovir (AIC246, MK-8228) is a novel anti-CMV compound which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors. |
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S4946 |
2,3-Dihydroxybenzoic acid2,3-Dihydroxybenzoic acid (Pyrocatechuic acid, 3-Hydroxysalicylic acid, Hypogallic acid) is a natural phenol found in Phyllanthus acidus and in the aquatic fern Salvinia molesta, also a product of human aspirin metabolism. It is a potentially useful iron-chelating drug and has antimicrobial properties. |
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S4647 |
Cefmenoxime hydrochlorideCefmenoxime (SCE-1365), a potent inhibitor of Enterobacteriaceae, is a cephalosporin antibiotic that is administered intravenously or intramuscularly. |
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S5499 |
AmantadineAmantadine (1-Adamantanamine, 1-Adamantylamine, 1-Aminoadamantane) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is an M2 inhibitor which blocks the ion channel formed by the M2 protein that spans the viral membrane. |
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S4602 |
Acetohydroxamic acidAcetohydroxamic acid (N-Hydroxyacetamide, Methylhydroxamic acid, Acetic acid|oxime, Lithostat) is an Urease Inhibitor. In the urine, it acts as an antagonist of the bacterial enzyme urease. |
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S8133 |
ResiquimodResiquimod (R-848) is an immune response modifier that acts as a potent TLR 7/TLR 8 agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α. Resiquimod reduces hepatitis C virus (HCV) infection. Phase 2. |
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S8588 |
ACSS2 inhibitorACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2). ACSS2 inhibitor also inhibits the respiratory syncytial virus (RSV). |
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S6549 |
PBTZ169PBTZ169 (macozinone), an antibiotic with antimycobacterial activity, is an irreversible inhibitor of DprE1. |
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S9303 |
Saikosaponin B2Saikosaponin B2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry. |
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S9018 |
LuteolosideLuteoloside (Cynaroside, Luteolin 7-β-D-Glucopyranoside) is a member of the flavonoids family that exhibits several bioactivities including anti-microbial and anti-cancer activities. It is an inhibitor of 3C Protease of Enterovirus 71 with an IC50 value of 0.36 mM. |
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S5345 |
NerolidolNerolidol (Peruviol) is a naturally occurring sesquiterpene found in the essential oils of many types of plants and flowers. It has diverse range of pharmacological and biological activities including antioxidant, anti-microbial, anti-biofilm, anti-parasitic, insecticidal, anti-ulcer, skin penetration enhancer, anti-tumor, anti-nociceptive and anti-inflammatory properties. |
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S7775 |
EmricasanEmricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection. |
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S7273 |
SC75741SC75741 is a potent NF-κB inhibitor with EC50 of 200 nM. SC75741 efficiently blocks influenza virus propagation. |
![]() ![]() Immunofluorescence of NF-κB (p65) (200×). SK-OV-3 and A2780S cells were treated with different compounds (vehicle, 5 μM JSH-23, 5 μM SC75741, 5 μM CAPE, 4 μM MIL, 4 μM MIL combined with pre-treated 5 μM JSH-23, 4 μM MIL combined with pre-treated 5 μM SC75741, 4 μM MIL combined with pre-treated 5 μM CAPE) for 48 h. NF-κB(p65) was detected by a fluorescence microscopy. The nuclei were stained with Hoechst 33258.
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S8068 |
ChaetocinChaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively. Chaetocin is an anticancer agent and inhibitor of thioredoxin reductase (TrxR). |
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S9063 |
HarringtonineHarringtonine is a natural cephalotaxine alkaloid that inhibits protein biosynthesis. It also exhibits antiviral and anticancer activities. |
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S4430 |
Hydroxychloroquine SulfateHydroxychloroquine Sulfate (HCQ) is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR) 7/9. |
![]() ![]() C, SA-beta gal staining results of A549-LKB1 cells treated by trametinib (30 nmol/L), radiotherapy (2 Gy), and HCQ (50 μmol/L). Cells were treated by HCQ and/or trametinib 4 hours prior to radiotherapy. Drugs were washed out 24 hours after radiotherapy. Cells were incubated for additional 48 hours before staining. D, Clonogenic survival assay of A549-LKB1 cells treated with trametinib (30 nmol/L) and HCQ (50 μmol/L).
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S9064 |
TrilobatinTrilobatin (P-Phlorizin), a natural flavonoid lipid molecule, is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope and exihibits anti-oxidant and anti-inflammatory effect. |
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S4303 |
9-Aminoacridine9-Aminoacridine (Aminacrine) is a highly fluorescent dye used clinically as a topical antiseptic and experimentally as a mutagen, an intracellular pH indicator and a negative mode small molecule MALDI matrix. |
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S5704 |
MyclobutanilMyclobutanil is a widely used triazole fungicide and also a steroid demethylation inhibitor. |
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S4983 |
Sorbic acidSorbic acid (2,4-Hexadienoic acid) is a naturally occurring compound that originated from the unripe berries of the Rowan Tree. It inhibits various bacteria, including sporeformers, at various stages of their life cycle (germination, outgrowth and cell division). |
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S9070 |
IsoxanthohumolIsoxanthohumol is one of the most important prenylflavonoids found in hops. It exhibits an antiproliferative activity against human breast cancer cell lines, ovarian cancer, prostate cancer, and colon cancer cells. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV). |
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S4198 |
AminothiazoleAminothiazole can be used as a thyroid inhibitor and it has antibacterial activity. |
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S9072 |
SwerosideSweroside, a bioactive herbal ingredient isolated from Fructus Corni, exhibits diverse biological activities, such as anti-fungal, anti-diabetic, anti-inflammatory, and anti-tumor effects. |
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S5927 |
ProguanilProguanil (chlorguanide, chloroguanide) is a prophylactic antimalarial drug. It inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication. |
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S3710 |
Fosfomycin calciumFosfomycin (phosphomycin, phosphonomycin) is bactericidal and inhibits bacterial cell wall biogenesis by inactivating the enzyme UDP-N-acetylglucosamine-3-enolpyruvyltransferase, also known as MurA. It enters the bacterial cell through the glycerophosphate transporter. |
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S5166 |
BenzoyleneureaBenzoyleneurea (2,4-Dihydroxyquinazoline, Quinazolinedione, Quinazoline-2,4-diol) scaffold is used in the synthesis of novel protein geranylgeranyltransferase-I inhibitors. |
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S5025 |
EfinaconazoleEfinaconazole (KP-103) is an inhibitor of 14 alpha-demethylase which is involved in the biosynthesis of ergosterol, a constituent of fungal cell membranes. |
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S4104 |
Diminazene AceturateDiminazene is a di-amidine also known as 4,4-(1-Triazene–1,3–diyl)bis(benzenecarboximidamide), used as an effective trypanocidal agent. |
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S4105 |
Closantel SodiumClosantel is a gram positive antibacterial activity inhibitor, inhibiting the KinA/Spo0F system with IC50 of 3.8 μM. |
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S4106 |
ClosantelClosantel (R-31520) is a gram positive antibacterial activity inhibitor, inhibiting the KinA/Spo0F system with IC50 of 3.8 μM. |
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S3711 |
Carbasalate CalciumCarbasalate calcium (Iromin, Alcacyl, Omegin, Rheomin, Solupsan) is an analgesic, antipyretic, and anti-inflammatory drug as well as a platelet aggregation inhibitor. |
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S4701 |
2-Deoxy-D-glucose (2-DG)2-Deoxy-D-glucose (2-DG, 2-deoxyglucose, NSC 15193), an analog of glucose, is a glycolytic inhibitor with antiviral activity. 2-Deoxy-D-glucose induces apoptosis and inhibits Herpes Simplex Virus type-1 (HSV-1) receptor expression. |
![]() ![]() (B) 2-DG activates AMPK and suppresses H3K27me3, PRC2 of ovarian cancer cells in normoglycemic condition.
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S9341 |
3,4-Dimethoxycinnamic acid3,4-Dimethoxycinnamic acid (Caffeic acid dimethyl ether) is a bioavailable coffee component as a perspective anti-prion compound and bind potently to prion protein with a Kd of 405 nM. |
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S4515 |
Ademetionine disulfate tosylateAdemetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions. Ademetionine possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. |
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