Anti-infection

阻害剤の選択性比較

カタログ番号	製品カタログ	溶解度(25°C)
カタログ番号	製品カタログ	水	DMSO	アルコール
S5001	Tofacitinib (CP-690550) Citrate	<1 mg/mL	100 mg/mL	'<1 mg/mL
S4157	Chloroquine diphosphate	100 mg/mL	<1 mg/mL	<1 mg/mL
E0206	Ginkgetin	-1 mg/mL	50 mg/mL	-1 mg/mL
S2572	Streptomycin sulfate	89 mg/mL	<1 mg/mL	<1 mg/mL
S8279	Shikonin (C.I. 75535)	<1 mg/mL	57 mg/mL	23 mg/mL
S3226	Dehydroabietic acid	-1 mg/mL	100 mg/mL	-1 mg/mL
S4945	Ethacridine lactate	69 mg/mL	69 mg/mL	''20 mg/mL
S5184	Dexamethasone palmitate	<1 mg/mL	100 mg/mL	''100 mg/mL
S3308	Caftaric acid	-1 mg/mL	100 mg/mL	-1 mg/mL
S1553	Delafloxacin (ABT-492)	<1 mg/mL	88 mg/mL	'<1 mg/mL
S4946	2,3-Dihydroxybenzoic acid	-1 mg/mL	30 mg/mL	-1 mg/mL
S8068	Chaetocin	<1 mg/mL	100 mg/mL	<1 mg/mL
S4430	Hydroxychloroquine Sulfate (NSC 4375)	67 mg/mL	<1 mg/mL	''<1 mg/mL
S4303	9-Aminoacridine	<1 mg/mL	38 mg/mL	'38 mg/mL
S5927	Proguanil	<1 mg/mL	51 mg/mL	'51 mg/mL
S4417	Ceftaroline Fosamil	<1 mg/mL	73 mg/mL	''''<1 mg/mL
S6771	MAC-545496	˂1 mg/mL	84 mg/mL	˂1 mg/mL
S3711	Carbasalate Calcium	91 mg/mL	11 mg/mL	<1 mg/mL
S9341	3,4-Dimethoxycinnamic acid	-1 mg/mL	42 mg/mL	-1 mg/mL
S4515	Ademetionine disulfate tosylate	79 mg/mL	79 mg/mL	<1 mg/mL
S2430	Azodicarbonamide	<1 mg/mL	23 mg/mL	<1 mg/mL
S6802	Etosalamide	6 mg/mL	42 mg/mL	'42 mg/mL
S7867	Oleuropein	100 mg/mL	100 mg/mL	100 mg/mL
S3261	Myrislignan	-1 mg/mL	100 mg/mL	-1 mg/mL
S4549	Antimonyl potassium tartrate trihydrate	100 mg/mL	<1 mg/mL	<1 mg/mL
S7465	FTI 277 HCl	17 mg/mL	96 mg/mL	'14 mg/mL
S1958	Sulbactam	47 mg/mL	47 mg/mL	47 mg/mL
S3269	Acetylcorynoline	-1 mg/mL	40 mg/mL	-1 mg/mL
S3270	Genipin 1-O-beta-D-gentiobioside	-1 mg/mL	100 mg/mL	-1 mg/mL
S3279	Polyphyllin B (Formosanin C)	-1 mg/mL	100 mg/mL	-1 mg/mL
S1282	Artemisinin	<1 mg/mL	57 mg/mL	24 mg/mL
S2264	Artemether	<1 mg/mL	60 mg/mL	60 mg/mL
S2479	Lincomycin HCl	89 mg/mL	89 mg/mL	<1 mg/mL
S1644	Nitrofural	<1 mg/mL	40 mg/mL	<1 mg/mL
S4237	Primaquine Diphosphate	91 mg/mL	91 mg/mL	<1 mg/mL
S2469	Fleroxacin	<1 mg/mL	<1 mg/mL	<1 mg/mL
S3116	Sulfathiazole	<1 mg/mL	51 mg/mL	<1 mg/mL
S2511	Sulfadoxine	<1 mg/mL	62 mg/mL	<1 mg/mL
S3067	Chlorhexidine 2HCl	<1 mg/mL	100 mg/mL	<1 mg/mL
S4147	Azithromycin Dihydrate	10 mg/mL	100 mg/mL	100 mg/mL
S4191	Betamipron	<1 mg/mL	39 mg/mL	39 mg/mL
S2537	Secnidazole	37 mg/mL	37 mg/mL	37 mg/mL
S4195	Broxyquinoline	<1 mg/mL	17 mg/mL	<1 mg/mL
S4196	Ethacridine lactate monohydrate	5 mg/mL	72 mg/mL	<1 mg/mL
S2612	Ribitol	30 mg/mL	30 mg/mL	<1 mg/mL
S4726	Lauric Acid	20 mg/mL	40 mg/mL	40 mg/mL
S3288	Absinthin	-1 mg/mL	10 mg/mL	-1 mg/mL
S3941	Pinocembrin	<1 mg/mL	51 mg/mL	51 mg/mL
S4579	Resorcinol	22 mg/mL	22 mg/mL	22 mg/mL
S9564	p-Hydroxy-cinnamic Acid	<1 mg/mL	33 mg/mL	33 mg/mL
S6288	Chlorhexidine diacetate	-1 mg/mL	100 mg/mL	-1 mg/mL
S5366	Fipronil	-1 mg/mL	87 mg/mL	-1 mg/mL
S4420	Mefloquine HCl	<1 mg/mL	82 mg/mL	82 mg/mL
S4142	Clopidol	<1 mg/mL	1 mg/mL	<1 mg/mL
S4592	Captisol (SBE-β-CD)	100 mg/mL	<1 mg/mL	<1 mg/mL
S5700	Phthalylsulfathiazole	-1 mg/mL	80 mg/mL	'-1 mg/mL
S4041	Olsalazine Sodium	41 mg/mL	4 mg/mL	<1 mg/mL
S4250	Sulfamethoxypyridazine	<1 mg/mL	56 mg/mL	'<1 mg/mL
S5397	Chlorhexidine	-1 mg/mL	100 mg/mL	-1 mg/mL
S2271	Berberine chloride (NSC 646666)	<1 mg/mL	40 mg/mL	<1 mg/mL
S2282	Cinchonidine	<1 mg/mL	59 mg/mL	59 mg/mL
S5475	Novaluron	-1 mg/mL	99 mg/mL	'-1 mg/mL
S3218	Amiloxate			' mg/mL
S5963	Sulfathiazole sodium	55 mg/mL	55 mg/mL	''<1 mg/mL
S5967	Berberine chloride hydrate	39 mg/mL	78 mg/mL	'<1 mg/mL
S4172	Cetylpyridinium Chloride	68 mg/mL	68 mg/mL	68 mg/mL
S6243	Ethyl pyruvate			' mg/mL
S3695	Cystamine dihydrochloride	45 mg/mL	14 mg/mL	'2 mg/mL
S4175	Sulfaguanidine	<1 mg/mL	43 mg/mL	<1 mg/mL
S2395	Rheochrysidin	<1 mg/mL	1 mg/mL	<1 mg/mL
S3787	Picroside I	-1 mg/mL	98 mg/mL	-1 mg/mL
S9016	Dipsacoside B	-1 mg/mL	100 mg/mL	-1 mg/mL
S5908	Garenoxacin	<1 mg/mL	2 mg/mL	<1 mg/mL
S3649	Ceftazidime	100 mg/mL	4 mg/mL	<1 mg/mL
S4062	Ronidazole	<1 mg/mL	40 mg/mL	<1 mg/mL
S4971	Buparvaquone	<1 mg/mL	65 mg/mL	'4 mg/mL
S6761	Dalfopristin	<1 mg/mL	100 mg/mL	''''100 mg/mL
S4192	Chlorquinaldol	<1 mg/mL	46 mg/mL	6 mg/mL
S5292	Diazolidinyl urea	-1 mg/mL	55 mg/mL	-1 mg/mL
S3210	3'-Hydroxy-4'-methoxyacetophenone	<1 mg/mL	33 mg/mL	33 mg/mL
S5961	Prednisolone disodium phosphate	97 mg/mL	97 mg/mL	'''<1 mg/mL
S5887	Khellin	<1 mg/mL	26 mg/mL	7 mg/mL
S4081	Sulfacetamide Sodium	51 mg/mL	19 mg/mL	<1 mg/mL
S4759	p-Coumaric Acid	<1 mg/mL	32 mg/mL	'32 mg/mL
S7411	Ascomycin (FK520)	<1 mg/mL	100 mg/mL	100 mg/mL
S0146	Broxaldine	<1 mg/mL	30 mg/mL	<1 mg/mL
S6019	2-Phenylphenol	-1 mg/mL	34 mg/mL	-1 mg/mL
S9387	Maackiain	-1 mg/mL	56 mg/mL	-1 mg/mL
S3364	3-Hydroxyphenylacetic acid	30 mg/mL	30 mg/mL	'''30 mg/mL
S9084	Rhoifolin	-1 mg/mL	100 mg/mL	-1 mg/mL
S3801	Sodium Houttuyfonate	<1 mg/mL	2 mg/mL	<1 mg/mL
S2613	Clorsulon	<1 mg/mL	76 mg/mL	7 mg/mL
S6442	Chlorphenesin	10 mg/mL	41 mg/mL	41 mg/mL
S9342	1,4-Naphthoquinone	-1 mg/mL	32 mg/mL	-1 mg/mL
S2564	Cloxacillin Sodium	55 mg/mL	55 mg/mL	25 mg/mL
S9112	Kaempferitrin	-1 mg/mL	100 mg/mL	-1 mg/mL
S5096	SulfadiMethoxine sodium	-1 mg/mL	66 mg/mL	'-1 mg/mL
S9113	Ononin	-1 mg/mL	86 mg/mL	-1 mg/mL
S5099	4-Aminophenylarsonic acid	-1 mg/mL	43 mg/mL	-1 mg/mL
S6459	Nifurtimox	<1 mg/mL	57 mg/mL	<1 mg/mL
S4232	Nithiamide	<1 mg/mL	37 mg/mL	<1 mg/mL
S3618	Acetylspiramycin (ASPM)	<1 mg/mL	100 mg/mL	'15 mg/mL
P1201	LL37 (Human cathelicidin)	50 mg/mL	-1 mg/mL	-1 mg/mL
S4236	Proflavine Hemisulfate	22 mg/mL	<1 mg/mL	<1 mg/mL
S3746	Lumefantrine	<1 mg/mL	13 mg/mL	<1 mg/mL
S5212	Imidazolidinyl Urea	-1 mg/mL	77 mg/mL	'-1 mg/mL
S5210	Sulfamethazine Sodium Salt	-1 mg/mL	60 mg/mL	-1 mg/mL
S0443	Desciclovir	25 mg/mL	42 mg/mL	'3 mg/mL
S4678	Povidone iodine	28 mg/mL	28 mg/mL	'28 mg/mL
S9131	Punicalagin	-1 mg/mL	100 mg/mL	-1 mg/mL
S3139	Methenamine	<1 mg/mL	28 mg/mL	9 mg/mL
S5405	Propylparaben	<1 mg/mL	36 mg/mL	36 mg/mL
S4242	Cetrimonium Bromide (CTAB)	100 mg/mL	5 mg/mL	100 mg/mL
S5214	Imidocarb dipropionate	-1 mg/mL	39 mg/mL	-1 mg/mL
S6461	Permethrin	<1 mg/mL	78 mg/mL	19 mg/mL
S3978	5-Phenyl-2,4-pentadienoic acid	-1 mg/mL	6 mg/mL	'-1 mg/mL
S3220	Trigonelline	-1 mg/mL	50 mg/mL	-1 mg/mL
S5390	N-(Hytroxymethy)micotinamide	-1 mg/mL	30 mg/mL	'-1 mg/mL
S5355	Piperaquine phosphate	2 mg/mL	<1 mg/mL	-1 mg/mL
S9560	Anisodamine Hydrobromide	-1 mg/mL	77 mg/mL	-1 mg/mL
S5005	Cefotiam hydrochloride	-1 mg/mL	100 mg/mL	'-1 mg/mL
S1962	Sulphadimethoxine	<1 mg/mL	62 mg/mL	<1 mg/mL
S4555	Carsalam	<1 mg/mL	32 mg/mL	2 mg/mL
S7896	Sodium Tauroursodeoxycholate (TUDC)	100 mg/mL	100 mg/mL	71 mg/mL
S9185	Nitidine Chloride	-1 mg/mL	11 mg/mL	-1 mg/mL

Anti-infection製品

All (132) Anti-infection阻害剤(27) Anti-infectionモジュレータ(3)

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S5001	Tofacitinib (CP-690550) Citrate Tofacitinib citrate (CP-690550, Tasocitinib) is a novel inhibitor of JAK with IC50 of 1 nM, 20 nM and 112 nM against JAK3, JAK2, and JAK1, respectively. Tofacitinib citrate has anti-infection activity.	Blood, 2022, blood.2021012366 J Control Release, 2022, S0168-3659(22)00163-8 Mol Neurodegener, 2022, 17(1):7	CP-690550 reduced the severity of ischemic damage. (A) CP-690550 (10 μM) suppressed IL-17 production by cdT cells and activated memory T cells. cdT cells and CD4+ CD44+ memory T cells isolated from C5BL6J mice through flow cytometry were stimulated for 24 h with plate-bound monoclonal antibodies to CD3 (2 ng/ml) and CD28 (1 ng/ml) in the presence or absence of IL-23 (25 ng/ml). IL-17A production and IL-17A expression level were measured by quantitative RT-PCR (a) and ELISA (b). (B) CBF reduction after brain ischemia. (C) Time-dependent changes in neurological score. *p < 0.05. (D) Infarct volume as visualized through TTC staining on day 3 in CP-690550 (CP)- and vehicle-treated mice.
S4157	Chloroquine diphosphate Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Chloroquine is also an inhibitor of toll-like receptors (TLRs).	Phytomedicine, 2022, 98:153958 Bone, 2022, 154:116262 Cancer Cell, 2021, S1535-6108(21)00659-0	NCI-H929 EV and miR-137 OE cells were treated with ATM activator Chloroquine Phosphate (CQ), specific ATM inhibitor KU-55933, and ATR inhibitor AZ20 for 12 hr. Immunoblotting showed the expression of p-ATM, p-Chk2, p-BRCA1, p-ATR and p-Chk1.
E0206^新	Ginkgetin Ginkgetin is a biflavone from Ginkgo biloba leaves with anti-cancer, anti-inflammatory, anti-microbial, anti-adipogenic, and neuroprotective activities.
S2572	Streptomycin sulfate Streptomycin sulfate is a sulfate salt of streptomycin that is a protein synthesis inhibitor.	Front Microbiol, 2021, 12:761113 Life Sci, 2021, 282:119798 Biosci Rep, 2021, BSR20200842
S8279	Shikonin (C.I. 75535) Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844), a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.	Adv Sci (Weinh), 2022, 10.1002/advs.202104055 Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7 Bioengineered, 2022, 13(3):5928-5941
S3226	Dehydroabietic acid Dehydroabietic acid (DAA, DHAA), a naturally occurring diterpene resin acid derived from coniferous plants such as Pinus and Picea, displays anti-inflammatory activity via suppression of Src-, Syk-, and TAK1-mediated pathways.
S4945	Ethacridine lactate Ethacridine lactate (Acrinol) is an aromatic organic compound based on acridine used as an antiseptic agent. Ethacridine lactate is also a poly(ADP-ribose) glycohydrolase (PARG) inhibitor.
S5184	Dexamethasone palmitate Dexamethasone palmitate (DXP), a lipophilic prodrug of Dexamethasone (DXM), is a glucocorticoid receptor agonist with a 47-fold lower affinity for the glucocorticoid receptor than DXM. Dexamethasone palmitate (DXP) exhibits anti-inflammatory activity.	Dis Model Mech, 2022, dmm.049109 Hematology, 2022, 27(1):32-42
S3308	Caftaric acid Caftaric acid (CA, Caffeoyl tartaric acid) is a natural product that shows anti-oxidant and anti-inflammatory effects.
S1553	Delafloxacin (ABT-492) Delafloxacin (ABT-492, RX-3341, WQ-3034) is a new fluoroquinolone against 155 aerobic and 171 anaerobic pathogens.
S4946	2,3-Dihydroxybenzoic acid 2,3-Dihydroxybenzoic acid (Pyrocatechuic acid, 3-Hydroxysalicylic acid, Hypogallic acid) is a natural phenol found in Phyllanthus acidus and in the aquatic fern Salvinia molesta, also a product of human aspirin metabolism. It is a potentially useful iron-chelating drug and has antimicrobial properties.
S8068	Chaetocin Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively. Chaetocin is an anticancer agent and inhibitor of thioredoxin reductase (TrxR).	Eye Vis (Lond), 2022, 9(1):4 Free Radic Biol Med, 2021, 178:147-160 Cancer Discov, 2021, candisc.0872.2020
S4430	Hydroxychloroquine Sulfate (NSC 4375) Hydroxychloroquine Sulfate (NSC 4375, HCQ) is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR) 7/9.	Cell Death Dis, 2022, 13(3):197 Neurosci Bull, 2022, 10.1007/s12264-022-00818-9 Autophagy, 2021, 1-14	C, SA-beta gal staining results of A549-LKB1 cells treated by trametinib (30 nmol/L), radiotherapy (2 Gy), and HCQ (50 μmol/L). Cells were treated by HCQ and/or trametinib 4 hours prior to radiotherapy. Drugs were washed out 24 hours after radiotherapy. Cells were incubated for additional 48 hours before staining. D, Clonogenic survival assay of A549-LKB1 cells treated with trametinib (30 nmol/L) and HCQ (50 μmol/L).
S4303	9-Aminoacridine 9-Aminoacridine (Aminacrine) is a highly fluorescent dye used clinically as a topical antiseptic and experimentally as a mutagen, an intracellular pH indicator and a negative mode small molecule MALDI matrix.
S5927	Proguanil Proguanil (chlorguanide, chloroguanide) is a prophylactic antimalarial drug. It inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication.	Sci Adv, 2021, 7(27)eabh3032
S4417	Ceftaroline Fosamil Ceftaroline fosamil (CX-0903, DSP-5990, PPI-0903, TAK-599, Teflaro, Zinforo) is a cephalosporin with activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA).
S6771	MAC-545496 MAC-545496 is a nanomolar glycopeptide-resistance-associated protein R(GraR) inhibitor with strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM). MAC-545496 can reverse β-lactam resistance in methicillin-resistant strains and synergize with CAMPs. MAC-545496 shows remarkable activity in macrophages and attenuates S. aureus virulence in a G. mellonella larvae infection model.
S3711	Carbasalate Calcium Carbasalate calcium (Iromin, Alcacyl, Omegin, Rheomin, Solupsan) is an analgesic, antipyretic, and anti-inflammatory drug as well as a platelet aggregation inhibitor.
S9341	3,4-Dimethoxycinnamic acid 3,4-Dimethoxycinnamic acid (Caffeic acid dimethyl ether) is a bioavailable coffee component as a perspective anti-prion compound and bind potently to prion protein with a Kd of 405 nM.
S4515	Ademetionine disulfate tosylate Ademetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions. Ademetionine possesses anti-inflammatory activity and has been used in treatment of chronic liver disease.
S2430	Azodicarbonamide Azodicarbonamide is the first known nucleocapsid inhibitor that inhibits HIV-1 and a broad range of retroviruses by targeting the nucleocapsid CCHC domains. Azodicarbonamide inhibits the HIV-1_RF-induced cytopathicity of CEM-SS cells with an EC50 of 38 µM in a standard cell-based antiviral assay .
S6802	Etosalamide Etosalamide (Ethosalamide) is an anti-inflammatory drug with antipyretic and analgesics properties.
S7867	Oleuropein Oleuropein is an antioxidant polyphenol isolated from olive leaf. Oleuropein exerts antioxidant, anti-inflammatory and anti-atherogenic effects and suppresses the adipocyte differentiation in vitro. Oleuropein inhibits PPARγ activity. Oleuropein exerts anti-adipogenic effect through direct inhibition of PPARγ transcriptional activity. Oleuropein also inhibits aromatase. Oleuropein induces apoptosis. Phase 2.	J Med Virol, 2019, 91(8):1440-1447
S3261	Myrislignan Myrislignan, a lignan isolated from Myristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan inhibits interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α). Myrislignan significantly inhibits the expressions of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) dose-dependently in LPS-stimulated macrophage cells. Myrislignan inhibits the NF-κB signalling pathway activation.
S4549	Antimonyl potassium tartrate trihydrate Antimonyl potassium tartrate trihydrate (Tartar emetic) is a powerful emetic, also used in the treatment of schistosomiasis and leishmaniasis.
S7465	FTI 277 HCl FTI 277 HCl is the methyl ester of FTI 277, which is a potent and selective farnesyltransferase (FTase) inhibitor with IC50 of 500 pM, about 100-fold selectivity over the closely related GGTase I. FTI 277 HCl inhibits cell growth and induces apoptosis. FTI 277 HCl is effective in clearing HDV viremia.	PLoS Biol, 2021, 19(4):e3001134 Cell Struct Funct, 2021, 46(1):1-9 Nat Commun, 2019, 10(1):273	(A) HCT 116 cells were treated with Tram (0, 30, or 60 nM), and then treated with 10 μM FTI-277/4 μM GGTI-298 or vehicle control for 48 hr. CCK8 assays were performed to assess cell proliferation and growth. The data from a representative example of three independent experiments are presented as the mean±SD. (B) SW480 and MDA-MB-231 cells were treated with Tram (0, 80, 160 nM), and then treated with 10 μM FTI-277/4 μM GGTI-298 or vehicle control for 48 hr. CCK8 assays were performed to assess cell proliferation and growth. The data from a representative example of three independent experiments are presented as the mean±SD.
S1958	Sulbactam Sulbactam is a beta-lactamase inhibitor with an average IC50 of 0.8 μM.
S3269	Acetylcorynoline Acetylcorynoline, a major alkaloid component derived from Corydalis bungeana which is a traditional Chinese medical herb, shows anti-inflammatory properties. Acetylcorynoline may decrease egl-1 expression to suppress apoptosis pathways and increase rpn5 expression to enhance the activity of proteasomes.
S3270	Genipin 1-O-beta-D-gentiobioside Genipin 1-O-beta-D-gentiobioside (GG, Genipin 1-β-D-gentiobioside, Genipin 1-gentiobioside, Genipin 1-β-gentiobioside, Genipin gentiobioside) is a bioactive iridoid glycoside isolated from Gardenia jasminoides Ellis (Zhizi in Chinese) that exhibits hepatoprotective, anti-inflammatory, antioxidant, and antithrombotic activities.
S3279	Polyphyllin B (Formosanin C) Polyphyllin B (Formosanin C, FC), a diosgenin saponin isolated from Paris formosana, is an immunomodulator with antitumor activity. Polyphyllin B (Formosanin C, FC) induces apoptosis.	Oncol Lett, 2021, 22(1):550
S1282	Artemisinin Artemisinin (Qinghaosu, Artemisinine) is a sesquiterpene endoperoxide which is a potent antimalarial agent.	Front Immunol, 2021, 12:634368 Int Immunopharmacol, 2021, 95:107541 Antiviral Res, 2020, 29:104810
S2264	Artemether Artemether (SM-224, CGP 56696) is an antimalarial for the treatment of resistant strains of falciparum malaria.	Hum Cell, 2022, 10.1007/s13577-022-00671-y Sci Rep, 2021, 11(1):14571 Hum Cell, 2021, 34(6):1911-1918	Schistosomicidal effects of PZQ, ART(Artemether) and OXA on 14-day schistosomula. Magnification of the in vitro-cultured schistosomula treated with PZQ, ART, and OXA at 10 μM. Drugs were added at day 14 and schistosomula were analyzed at day 21 (late treatment). 0.1% DMSO in medium (solvent of the drugs; used as negative control) had no effect on schistosomula development.
S2479	Lincomycin HCl Lincomycin hydrochloride (Lincocin, NSC 70731) is the monohydrated salt of lincomycin, a substance produced by the growth of a member of the lincolnensis group of Streptomyces lincolnensis.	Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 10.1007/s13577-021-00639-4 Hum Cell, 2021, 34(6):1911-1918
S1644	Nitrofural Nitrofural (Nitrofurazone) is a topical anti-infective agent with an IC50 of 22.83 ± 1.2 μM. (Rat LD50 = 590 mg/kg)
S4237	Primaquine Diphosphate Primaquine Diphosphate is a transmission-blocking anti-malarial clinically available, displaying a marked activity against gametocytes of all species of human malaria.	Front Pharmacol, 2021, 12:695009 Cell Syst, 2019, 8(2):97-108
S2469	Fleroxacin Fleroxacin (Ro 23-6240, AM-833) is a new broad-spectrum fluoroquinolone.
S3116	Sulfathiazole Sulfathiazole is an organosulfur compound that has been used as a short-acting sulfa drug.
S2511	Sulfadoxine Sulfadoxine (Sulphadoxine) is an ultra-long-lasting sulfonamide with an IC50 of 249 μg/ml for P. vivax.
S3067	Chlorhexidine 2HCl Chlorhexidine hydrochloride (NSC-185) is an antiseptic effective against a wide variety of gram-negative and gram-positive organisms.	BMC Microbiol, 2020, 20(1):275
S4147	Azithromycin Dihydrate Azithromycin Dihydrate is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin.	J Cell Biochem, 2022, 10.1002/jcb.30213 PLoS Comput Biol, 2020, 16(12):e1008489 bioRxiv, 2020, 2020.10.02.324228
S4191	Betamipron Betamipron (CS-443) is a chemical compound which is used together with panipenem to inhibit panipenem uptake into the renal tubule and prevent nephrotoxicity.
S2537	Secnidazole Secnidazole (Flagentyl, PM 185184, RP 14539) is a nitroimidazole anti-infective.
S4195	Broxyquinoline Broxyquinoline is an antiprotozoal agent and able to release oxygen free radicals from the water in mucous membranes.
S4196	Ethacridine lactate monohydrate Ethacridine lactate monohydrate is an aromatic organic compound based on acridine used as an antiseptic agent.	Carcinogenesis, 2014, 35(12):2822-30
S2612	Ribitol Ribitol (Adonitol) is a crystalline pentose alcohol and is formed by the reduction of ribose which is occurs naturally in the plant Adonis vernalis.
S4726	Lauric Acid Lauric Acid (dodecanoic acid, N-Dodecanoic acid, Dodecylic acid) is a saturated medium-chain fatty acid with a 12-carbon backbone. Lauric acid is found naturally in various plant and animal fats and oils, and is a major component of coconut oil and palm kernel oil.
S3288	Absinthin Absinthin (Absynthine) is a naturally produced triterpene lactone from Artemisia absinthium with anti-inflammatory properties. Absinthin significantly enhances the expression of matrix metalloproteinase-8 (MMP-8) and is a possible treatment candidate for Acute lung injury (ALI).
S3941	Pinocembrin Pinocembrin (Dihydrochrysin, Galangin flavanone, 5,7-Dihydroxyflavanone) is a major flavonoid molecule incorporated as multifunctional in the pharmaceutical industry. Its vast range of pharmacological activities has been well researched including antimicrobial, anti-inflammatory, antioxidant, and anticancer activities.	J Neuroinflammation, 2020, 17(1):337
S4573	m-Tolyl acetate m-Tolyl acetate is a pharmaceutical intermediate and antiseptic.
S4579	Resorcinol Resorcinol is a chemical compound that serves as an antiseptic,an disinfectant, and a chemical intermediate for the production of many other pharmaceuticals.
S9564	p-Hydroxy-cinnamic Acid p-Hydroxy-cinnamic Acid has in vitro antimalarial activity and in vivo anti-osteoporotic properties.
S6288	Chlorhexidine diacetate Chlorhexidine diacetate (Hibitane diacetate) is a disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.	BMC Microbiol, 2020, 20(1):275
S5366	Fipronil Fipronil (Fluocyanobenpyrazole, Termidor) is a recalcitrant phenylpyrazole-based pesticide used for flea/tick treatment and termite control that is distributed in urban aquatic environments via stormwater and contributes to stream toxicity.
S9094	Pogostone Pogostone is one of the secondary metabolites from Pogostemon cablin (Blanco) Benth. (Lamiaceae), serving as the effective component of the antimicrobial activity.	J Ethnopharmacol, 2021, 278:114250
S4420	Mefloquine HCl Mefloquine HCl is a blood schizonticide by inhibiting hemozoin formation, used as an antimalarial drug.	Mol Med Rep, 2021, 23(1)40 bioRxiv, 2020, 2020/9/20.4.7.30734 Int J Parasitol Drugs Drug Resist, 2018, 8(2):331-340	BALB/c mice, orally infected with E. multilocularis eggs, were treated by either mefloquine (100 mg/kg twice per week, n = 9), ABZ (200 mg/kg, 5 times per week, n = 8) or control-treated (placebo, n = 9). After 12 weeks of treatment, parasite lesion numbers in the liver were assessed microscopically (A).
S4142	Clopidol Clopidol (WR 61112) is an antiprotozoal agent.
S4592	Captisol (SBE-β-CD) Captisol (SBE-β-CD, Sulfobutylether-β-Cyclodextrin) is a novel, chemically modified cyclodextrin with a structure designed to optimize the solubility and stability of drugs.	Cell Metab, 2022, S1550-4131(22)00083-3 Cell Metab, 2022, 34(1):171-183.e6 Cell, 2021, S0092-8674(21)00690-5
S5700	Phthalylsulfathiazole Phthalylsulfathiazole (Sulfathalidine) is a broad-spectrum antimicrobial that can treat different types of infections including intestinal.
S4041	Olsalazine Sodium Olsalazine Sodium is an anti-inflammatory prodrug, which consists of two 5-ASA moieties linked by an azo bond.	Oncotarget, 2017, 8(1):228-237	Values represent the average scores for each group ± S.E. (N = 10 per group). The differences between individual experimental groups and 17 days DSS only group were statistically significant (p < 0.05) for all groups.
S6136	(±)-α-Bisabolol α-bisabolol is a small, plant-derived, oily sesquiterpene alcohol with some anti-inflammatory and even anti-microbial properties.
S5757	Isoeugenol Isoeugenol (4-Propenylguaiacol), an essential oil constituent of nutmeg, clove, and cinnamon, shows antimicrobial activity.
S4250	Sulfamethoxypyridazine Sulfamethoxypyridazine (CL 13494) is a long-acting sulfonamide for treatment of Dermatitis herpetiformis.
S5397	Chlorhexidine Chlorhexidine is a disinfectant and topical anti-infective agent that is active against Gram-positive and Gram-negative organisms, facultative anaerobes, aerobes, and yeasts.	J Cell Mol Med, 2021, 10.1111/jcmm.16673 BMC Microbiol, 2020, 20(1):275
S6173	Amylmetacresol Amylmetacresol is an antiseptic used to treat infections of the mouth and throat.
S6185	Arachidonic acid Arachidonic acid (Arachidonate) is an unsaturated, essential fatty acid found in animal and human fat as well as in the liver, brain, and glandular organs. It is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes.	Bone Res, 2022, 10(1):20
S2271	Berberine chloride (NSC 646666) Berberine chloride (NSC 646666, Natural Yellow 18) is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.	Front Pharmacol, 2021, 12:632201 Molecules, 2021, 26(5)1210 Biology (Basel), 2021, 10(3)250
S2282	Cinchonidine Cinchonidine is an alkaloid used in asymmetric synthesis in organic chemistry.	J Med Virol, 2019, 91(8):1440-1447
S5475	Novaluron Novaluron (Rimon) belongs to the class of insecticides called insect growth regulators with pesticide properties.
S3218	Amiloxate Amiloxate (Amiloxiate, Isoamyl Methoxycinnamate, Isopentyl 4-methoxycinnamate, Isoamyl 4-methoxycinnamate, Isoamyl p-methoxycinnamate, Isopentyl p-methoxycinnamate) is EMA-approved chemical UV-filter used in cosmetics. Amiloxate is a cinnamic acid derivative with anti-inflammatory activity.
S5963	Sulfathiazole sodium Sulfathiazole sodium, an antimicrobial agent, is an organosulfur compound that has been used as a short-acting sulfa drug.
S5967	Berberine chloride hydrate Berberine (Natural Yellow 18) chloride hydrate is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.	Front Pharmacol, 2021, 12:632201
S4172	Cetylpyridinium Chloride Cetylpyridinium chloride is a cationic quaternary ammonium compound used as oropharyngeal antiseptic.
S6243	Ethyl pyruvate Ethyl pyruvate (CTI-01) is a simple aliphatic ester of pyruvic acid and has been shown to have robust neuroprotective effects via its anti-inflammatory, anti-oxidative, and anti-apoptotic functions.
S3695	Cystamine dihydrochloride Cystamine dihydrochloride (Decarboxycystine, 2-Aminoethyl disulfide, 2,2'-Dithiobisethanamine) acts as an anti-infective agent, which is used in the treatment of urinary tract infections and also as a radiation-protective agent that interferes with sulfhydryl enzymes.
S4175	Sulfaguanidine Sulfaguanidine is a sulfonamide used as an anti-infective agent.
S2395	Rheochrysidin Rheochrysidin (Physcione) is an anthraquinone from roots of Rheum officinale Baill.	ACS Chem Biol, 2015, 10.1021/cb5009487	AmpC β-lactamase and MDH inhibition dose-response curves in the absence (black circles) and presence (red triangles) of DTT for (C and D) physcion.
S3787	Picroside I Picroside I (6'-Cinnamoylcatalpol), an iridoid glycoside, is a hepatoprotective agent which is reported to be antimicrobial and used against hepatitis B.
S9016	Dipsacoside B Dipsacoside B, extracted from the flowerbuds of Lonicera confusa DC, shows strong antimicrobial activity.
S5908	Garenoxacin Garenoxacin (T-3811ME, BMS-284756) is a novel des-F(6) quinolone that has been shown to be effective in vitro against a wide range of clinically important pathogens, including gram-positive and gram-negative aerobes and anaerobes.
S3649	Ceftazidime Ceftazidime is a third-generation cephalosporin that has activity against Gram-negative bacilli, including Pseudomonas aeruginosa.
S4062	Ronidazole Ronidazole is an antiprotozoal agent.
S4971	Buparvaquone Buparvaquone (Butalex) is a second-generation hydroxynaphthoquinone related to parvaquone, with novel features that make it a promising compound for the therapy and prophylaxis of all forms of theileriosis.
S6761	Dalfopristin Dalfopristin (RP54476) is a semi-synthetic analogue of ostreogyrcin A. Quinupristin/dalfopristin (Q/D) is a parental streptogramin with a spectrum of activity that includes Gram-positive pathogens, including those resistant to other classes of antimicrobial compounds.
S4192	Chlorquinaldol Chlorquinaldol is an antimicrobial agent used for local antisepsy.
S5292	Diazolidinyl urea Diazolidinyl urea (Germall II) is an antimicrobial preservative used in cosmetics.
S3210	3'-Hydroxy-4'-methoxyacetophenone 3'-Hydroxy-4'-methoxyacetophenone (Acetoisovanillone, Isoacetovanillone, Diosmin EP Impurity A) is an active P. spinosa extract with anti-inflammatory potential.
S5961	Prednisolone disodium phosphate Prednisolone disodium phosphate (Hydeltrasol, Prednisolone 21-phosphate disodium) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties that exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells.	J Immunotoxicol, 2021, 18(1):154-162 Eur J Rheumatol, 2021, 10.5152/eurjrheum.2021.20054
S5887	Khellin Khellin (Methafrone, Visammin, Ammivisnagen, Khellinorm, Medekellin, Viscardan, Kalangin), a compound isolated from the seeds of Ammi Visnaga Lam (Umbelliferae), is used to treat a variety of maladies.
S4081	Sulfacetamide Sodium Sulfacetamide Sodium is an anti-biotic.	G3 (Bethesda), 2020, 4;10(5):1585-1597
S4759	p-Coumaric Acid p-Coumaric acid (4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, 4-Coumaric acid, Trans-p-Coumaric acid, para-Coumaric Acid) is a hydroxy derivative of cinnamic acid found in a variety of edible plants and is reported to have antioxidant, anti-inflammatory, and antimicrobial activity.	Exp Ther Med, 2021, 21(5):503 J Nutr Biochem, 2015, 26(11):1379-84
S7411	Ascomycin (FK520) Ascomycin (FK520, FR 900520, Immunomycin), an FK-506 analog, is a neutral macrolide immunosuppressant, which prevents rejection after an organ transplant. Phase 3.	Melanoma Res, 2020, 30(4):325-335 Virol Sin, 2019, 34(6):648-661
S0146	Broxaldine Broxaldine (Brobenzoxaldine, AL307) is an antiprotozoal drug and can be used in leprosy.
S6019	2-Phenylphenol 2-Phenylphenol, found in lemon, is an antifungal agent and preservative used in food seasonings.
S9387	Maackiain Maackiain (Demethylpterocarpin) is a pterocarpan that is widely distributed in leguminous plants. It has anticancer and antimicrobial effects.
S3364	3-Hydroxyphenylacetic acid 3-Hydroxyphenylacetic acid (3-HPAA) is a phenolic acid mostly found in olive oil wastewater and an intestinal metabolite of the dietary flavonoid quercetin. 3-Hydroxyphenylacetic acid exhibits antimicrobial properties.
S9084	Rhoifolin Rhoifolin (Rhoifoloside, Apigenin 7-O-neohesperidoside, Apigenin-7-O-rhamnoglucoside), a natural glycoside of apigenin, has been obtained from the green leaves of Rhus succedanea and possesses a variety of significant biological activities including antioxidant, anti-inflammatory, antimicrobial, hepatoprotective and anticancer effects.
S3801	Sodium Houttuyfonate Sodium Houttuyfonate, the active compound of the Houttuynia plant, is mainly used for treating purulent skin infections, respiratory tract infections, including pneumonia in elderly patients, and chronic bronchitis.
S2613	Clorsulon Clorsulon (MK-401) is used in the treatment of Fasciola hepatica infections in calves and sheep.	Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 34(6):1911-1918 Hum Cell, 2021, 10.1007/s13577-021-00579-z
S6442	Chlorphenesin Chlorphenesin is a synthetic preservative used in skin care as a cosmetic biocide.
S9342	1,4-Naphthoquinone 1,4-Naphthoquinone (α-Naphthoquinone, para-naphthoquinone, P-Naphthoquinone), found in diesel exhaust particles and it is an active metabolite of naphthalene, is a fumigant insecticide.
S2564	Cloxacillin Sodium Cloxacillin Sodium is a sodium salt of cloxacillin that is a penicillinase-resistant, acid resistant, semi-synthetic penicillin.
S9112	Kaempferitrin Kaempferitrin (Lespenefril, Lespedin, Lespenephryl, Kaempferol 3,7-dirhamnoside), isolated from the leaves of Hedyotis verticillata and from Onychium japonicum, has antimicrobial, antioxidant, and anti-inflammatory activities.
S5096	SulfadiMethoxine sodium Sulfadimethoxine (Sulfadimethoxydiazine) is a long-lasting sulfonamide antimicrobial agent used to treat many infections including treatment of respiratory, urinary tract, enteric, and soft tissue infections.	Cell Death Dis, 2018, 9(6):646
S9113	Ononin Ononin (Formononetin glucoside, Formononetin 7-O-glucoside) is an isoflavone glycoside with anti-inflammtory effects.
S5099	4-Aminophenylarsonic acid 4-Aminophenylarsonic acid (Arsanilic Acid) is an organoarsenic compound with activity as an anti-infective agent.
S6459	Nifurtimox Nifurtimox (BAY-2502) is an antiprotozoal agent.
S4232	Nithiamide Nithiamide (CL 5279) is a non-5-nitroimidazole drugs.
S3618	Acetylspiramycin (ASPM) Acetylspiramycin (ASPM, Spiramycin II, Foromacidin B) is a macrolide antimicrobial agent.
P1201	LL37 (Human cathelicidin) LL37 (Human cathelicidin, Ropocamptide) is a cathelicidin-related antimicrobial peptide with potent chemotactic and immunomodulatory properties.
S4236	Proflavine Hemisulfate Proflavine Hemisulfate is a topical antiseptic by interchelating DNA, thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands.
S3746	Lumefantrine Lumefantrine (benflumetol) is an antimalarial agent used to treat acute uncomplicated malaria.	Antimicrob Agents Chemother, 2021, AAC.02137-20 ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00522
S5212	Imidazolidinyl Urea Imidazolidinyl Urea (Imidurea) is an antimicrobial agent used as preservative in cosmetics.
S5210	Sulfamethazine Sodium Salt Sulfamethazine (Sulfadimethyldiazine) is a sulfanilamide anti-infective agent used in the lifestock industry.
S0443	Desciclovir Desciclovir (DCV, 6-Deoxyacyclovir, BW A515U) is a prodrug of the antiherpetic agent acyclovir (ACV) that converted into ACV by xanthine oxidase in humans.
S4678	Povidone iodine Povidone iodine (Betadine, PVP iodine, PVP-I, Isodine) is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. It is used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol.
S9131	Punicalagin Punicalagin, a major ellagitannin found in pomegranate extracts, has been shown to have antioxidant, anti-inflammatory, and anticancer effects.	Cell, 2020, 30;181(3):637-652.e15. Cell, 2020, 30;181(3):637-652e15
S3139	Methenamine Methenamine is an antibiotic used for the treatment of urinary tract infection.
S5405	Propylparaben Propylparaben (Propyl 4-hydroxybenzoate, Propyl p-hydroxybenzoate, nipasol), a natural substance found in many plants and some insects, is an antimicrobial, preservative and flavouring agent.
S4242	Cetrimonium Bromide (CTAB) Cetrimonium Bromide (CTAB) is a known component of the broad-spectrum antiseptic cetrimide, which is a mixture of different quaternary ammonium salts.	Biochem Cell Biol, 2021, 10.1139/bcb-2020-0570 Micromachines (Basel), 2018, 9(6)
S5214	Imidocarb dipropionate Imidocarb is an antiprotozoal agent, used as dipropionate in the treatment of babesiosis and ehrlichiosis.	Nat Commun, 2017, 8(1):823
S6461	Permethrin Permethrin is a synthetic Type I pyrethroidal neurotoxic pesticide that has been responsible for accidental animal deaths.
S3978	5-Phenyl-2,4-pentadienoic acid 5-Phenyl-2,4-pentadienoic acid (5-Phenylpenta-2,4-dienoic acid) is used as Synthetic building block, anti-malarial agent.
S3220	Trigonelline Trigonelline (Trigenolline) is a plant alkaloid and a major component of coffee and fenugreek with anti-degranulation, anti-diabetic, antioxidant, anti-inflammatory, and neuroprotective effects. Trigonelline inhibits FcεRI-mediated intracellular signaling pathways, such as phosphorylation of PLCγ1, PI3K, and Akt. Trigonelline (Trigenolline) also inhibits the microtubule formation in RBL-2H3 cells.	Biomed Pharmacother, 2021, 143:112204
S5390	N-(Hytroxymethy)micotinamide N-(Hydroxymethyl)nicotinamide (Nikomethamide, Bilamid, N-hydroxymethylnicotinamide) is an antimicrobial agent.
S5355	Piperaquine phosphate Piperaquine phosphate is an orally active bisquinolone antimalarial drug.
S9560	Anisodamine Hydrobromide Anisodamine (6-Hydroxyhyoscyamine) is a naturally occurring atropine derivative and exhibits anti-inflammatory activity. It also inhibits α1-adrenergic receptors and muscarinic acetylcholine receptors (mAChRs).
S5005	Cefotiam hydrochloride Cefotiam hydrochloride (Halospor, Pansporin, Pansporine) is the hydrochloride salt form of cefotiam and has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.
S1962	Sulphadimethoxine Sulphadimethoxine is a non-reducing glucuronide.
S4555	Carsalam Carsalam (Carbonylsalicylamide) is a nonsteroidal anti-inflammatory drug.
S7896	Sodium Tauroursodeoxycholate (TUDC) Sodium Tauroursodeoxycholate (TUDC) is a water soluble bile salt, used for the treatment of gallstones and liver cirrhosis.	Microbiome, 2019, 7(1):145 Int J Biol Sci, 2019, 15(9):1905-1920 EBioMedicine, 2018, 37:269-280
S4521	DEET DEET (N,N-Diethyl-meta-toluamide, diethyltoluamide) is a commen active ingredient insect repellent.
S9185	Nitidine Chloride Nitidine Chloride, a benzophenanthridine alkaloid found in species of the genus Zanthoxylum, has an anti-malarial activity.	Int Immunopharmacol, 2021, 101(Pt A):108273 Front Cell Neurosci, 2020, 14:216

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S5001	Tofacitinib (CP-690550) Citrate Tofacitinib citrate (CP-690550, Tasocitinib) is a novel inhibitor of JAK with IC50 of 1 nM, 20 nM and 112 nM against JAK3, JAK2, and JAK1, respectively. Tofacitinib citrate has anti-infection activity.	Blood, 2022, blood.2021012366 J Control Release, 2022, S0168-3659(22)00163-8 Mol Neurodegener, 2022, 17(1):7	CP-690550 reduced the severity of ischemic damage. (A) CP-690550 (10 μM) suppressed IL-17 production by cdT cells and activated memory T cells. cdT cells and CD4+ CD44+ memory T cells isolated from C5BL6J mice through flow cytometry were stimulated for 24 h with plate-bound monoclonal antibodies to CD3 (2 ng/ml) and CD28 (1 ng/ml) in the presence or absence of IL-23 (25 ng/ml). IL-17A production and IL-17A expression level were measured by quantitative RT-PCR (a) and ELISA (b). (B) CBF reduction after brain ischemia. (C) Time-dependent changes in neurological score. *p < 0.05. (D) Infarct volume as visualized through TTC staining on day 3 in CP-690550 (CP)- and vehicle-treated mice.
S4157	Chloroquine diphosphate Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Chloroquine is also an inhibitor of toll-like receptors (TLRs).	Phytomedicine, 2022, 98:153958 Bone, 2022, 154:116262 Cancer Cell, 2021, S1535-6108(21)00659-0	NCI-H929 EV and miR-137 OE cells were treated with ATM activator Chloroquine Phosphate (CQ), specific ATM inhibitor KU-55933, and ATR inhibitor AZ20 for 12 hr. Immunoblotting showed the expression of p-ATM, p-Chk2, p-BRCA1, p-ATR and p-Chk1.
E0206^新	Ginkgetin Ginkgetin is a biflavone from Ginkgo biloba leaves with anti-cancer, anti-inflammatory, anti-microbial, anti-adipogenic, and neuroprotective activities.
S2572	Streptomycin sulfate Streptomycin sulfate is a sulfate salt of streptomycin that is a protein synthesis inhibitor.	Front Microbiol, 2021, 12:761113 Life Sci, 2021, 282:119798 Biosci Rep, 2021, BSR20200842
S8279	Shikonin (C.I. 75535) Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844), a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.	Adv Sci (Weinh), 2022, 10.1002/advs.202104055 Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7 Bioengineered, 2022, 13(3):5928-5941
S3226	Dehydroabietic acid Dehydroabietic acid (DAA, DHAA), a naturally occurring diterpene resin acid derived from coniferous plants such as Pinus and Picea, displays anti-inflammatory activity via suppression of Src-, Syk-, and TAK1-mediated pathways.
S4945	Ethacridine lactate Ethacridine lactate (Acrinol) is an aromatic organic compound based on acridine used as an antiseptic agent. Ethacridine lactate is also a poly(ADP-ribose) glycohydrolase (PARG) inhibitor.
S5184	Dexamethasone palmitate Dexamethasone palmitate (DXP), a lipophilic prodrug of Dexamethasone (DXM), is a glucocorticoid receptor agonist with a 47-fold lower affinity for the glucocorticoid receptor than DXM. Dexamethasone palmitate (DXP) exhibits anti-inflammatory activity.	Dis Model Mech, 2022, dmm.049109 Hematology, 2022, 27(1):32-42
S3308	Caftaric acid Caftaric acid (CA, Caffeoyl tartaric acid) is a natural product that shows anti-oxidant and anti-inflammatory effects.
S1553	Delafloxacin (ABT-492) Delafloxacin (ABT-492, RX-3341, WQ-3034) is a new fluoroquinolone against 155 aerobic and 171 anaerobic pathogens.
S4946	2,3-Dihydroxybenzoic acid 2,3-Dihydroxybenzoic acid (Pyrocatechuic acid, 3-Hydroxysalicylic acid, Hypogallic acid) is a natural phenol found in Phyllanthus acidus and in the aquatic fern Salvinia molesta, also a product of human aspirin metabolism. It is a potentially useful iron-chelating drug and has antimicrobial properties.
S8068	Chaetocin Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively. Chaetocin is an anticancer agent and inhibitor of thioredoxin reductase (TrxR).	Eye Vis (Lond), 2022, 9(1):4 Free Radic Biol Med, 2021, 178:147-160 Cancer Discov, 2021, candisc.0872.2020
S4430	Hydroxychloroquine Sulfate (NSC 4375) Hydroxychloroquine Sulfate (NSC 4375, HCQ) is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR) 7/9.	Cell Death Dis, 2022, 13(3):197 Neurosci Bull, 2022, 10.1007/s12264-022-00818-9 Autophagy, 2021, 1-14	C, SA-beta gal staining results of A549-LKB1 cells treated by trametinib (30 nmol/L), radiotherapy (2 Gy), and HCQ (50 μmol/L). Cells were treated by HCQ and/or trametinib 4 hours prior to radiotherapy. Drugs were washed out 24 hours after radiotherapy. Cells were incubated for additional 48 hours before staining. D, Clonogenic survival assay of A549-LKB1 cells treated with trametinib (30 nmol/L) and HCQ (50 μmol/L).
S4303	9-Aminoacridine 9-Aminoacridine (Aminacrine) is a highly fluorescent dye used clinically as a topical antiseptic and experimentally as a mutagen, an intracellular pH indicator and a negative mode small molecule MALDI matrix.
S5927	Proguanil Proguanil (chlorguanide, chloroguanide) is a prophylactic antimalarial drug. It inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication.	Sci Adv, 2021, 7(27)eabh3032
S4417	Ceftaroline Fosamil Ceftaroline fosamil (CX-0903, DSP-5990, PPI-0903, TAK-599, Teflaro, Zinforo) is a cephalosporin with activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA).
S6771	MAC-545496 MAC-545496 is a nanomolar glycopeptide-resistance-associated protein R(GraR) inhibitor with strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM). MAC-545496 can reverse β-lactam resistance in methicillin-resistant strains and synergize with CAMPs. MAC-545496 shows remarkable activity in macrophages and attenuates S. aureus virulence in a G. mellonella larvae infection model.
S3711	Carbasalate Calcium Carbasalate calcium (Iromin, Alcacyl, Omegin, Rheomin, Solupsan) is an analgesic, antipyretic, and anti-inflammatory drug as well as a platelet aggregation inhibitor.
S9341	3,4-Dimethoxycinnamic acid 3,4-Dimethoxycinnamic acid (Caffeic acid dimethyl ether) is a bioavailable coffee component as a perspective anti-prion compound and bind potently to prion protein with a Kd of 405 nM.
S4515	Ademetionine disulfate tosylate Ademetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions. Ademetionine possesses anti-inflammatory activity and has been used in treatment of chronic liver disease.
S2430	Azodicarbonamide Azodicarbonamide is the first known nucleocapsid inhibitor that inhibits HIV-1 and a broad range of retroviruses by targeting the nucleocapsid CCHC domains. Azodicarbonamide inhibits the HIV-1_RF-induced cytopathicity of CEM-SS cells with an EC50 of 38 µM in a standard cell-based antiviral assay .
S6802	Etosalamide Etosalamide (Ethosalamide) is an anti-inflammatory drug with antipyretic and analgesics properties.
S7867	Oleuropein Oleuropein is an antioxidant polyphenol isolated from olive leaf. Oleuropein exerts antioxidant, anti-inflammatory and anti-atherogenic effects and suppresses the adipocyte differentiation in vitro. Oleuropein inhibits PPARγ activity. Oleuropein exerts anti-adipogenic effect through direct inhibition of PPARγ transcriptional activity. Oleuropein also inhibits aromatase. Oleuropein induces apoptosis. Phase 2.	J Med Virol, 2019, 91(8):1440-1447
S3261	Myrislignan Myrislignan, a lignan isolated from Myristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan inhibits interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α). Myrislignan significantly inhibits the expressions of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) dose-dependently in LPS-stimulated macrophage cells. Myrislignan inhibits the NF-κB signalling pathway activation.
S4549	Antimonyl potassium tartrate trihydrate Antimonyl potassium tartrate trihydrate (Tartar emetic) is a powerful emetic, also used in the treatment of schistosomiasis and leishmaniasis.
S7465	FTI 277 HCl FTI 277 HCl is the methyl ester of FTI 277, which is a potent and selective farnesyltransferase (FTase) inhibitor with IC50 of 500 pM, about 100-fold selectivity over the closely related GGTase I. FTI 277 HCl inhibits cell growth and induces apoptosis. FTI 277 HCl is effective in clearing HDV viremia.	PLoS Biol, 2021, 19(4):e3001134 Cell Struct Funct, 2021, 46(1):1-9 Nat Commun, 2019, 10(1):273	(A) HCT 116 cells were treated with Tram (0, 30, or 60 nM), and then treated with 10 μM FTI-277/4 μM GGTI-298 or vehicle control for 48 hr. CCK8 assays were performed to assess cell proliferation and growth. The data from a representative example of three independent experiments are presented as the mean±SD. (B) SW480 and MDA-MB-231 cells were treated with Tram (0, 80, 160 nM), and then treated with 10 μM FTI-277/4 μM GGTI-298 or vehicle control for 48 hr. CCK8 assays were performed to assess cell proliferation and growth. The data from a representative example of three independent experiments are presented as the mean±SD.
S1958	Sulbactam Sulbactam is a beta-lactamase inhibitor with an average IC50 of 0.8 μM.

製品コード	製品説明	文献中Selleckの製品使用例
S3269	Acetylcorynoline Acetylcorynoline, a major alkaloid component derived from Corydalis bungeana which is a traditional Chinese medical herb, shows anti-inflammatory properties. Acetylcorynoline may decrease egl-1 expression to suppress apoptosis pathways and increase rpn5 expression to enhance the activity of proteasomes.
S3270	Genipin 1-O-beta-D-gentiobioside Genipin 1-O-beta-D-gentiobioside (GG, Genipin 1-β-D-gentiobioside, Genipin 1-gentiobioside, Genipin 1-β-gentiobioside, Genipin gentiobioside) is a bioactive iridoid glycoside isolated from Gardenia jasminoides Ellis (Zhizi in Chinese) that exhibits hepatoprotective, anti-inflammatory, antioxidant, and antithrombotic activities.
S3279	Polyphyllin B (Formosanin C) Polyphyllin B (Formosanin C, FC), a diosgenin saponin isolated from Paris formosana, is an immunomodulator with antitumor activity. Polyphyllin B (Formosanin C, FC) induces apoptosis.	Oncol Lett, 2021, 22(1):550

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製品説明

文献中Selleckの製品使用例

お客様のフィードバック

S3269

Acetylcorynoline

Acetylcorynoline, a major alkaloid component derived from Corydalis bungeana which is a traditional Chinese medical herb, shows anti-inflammatory properties. Acetylcorynoline may decrease egl-1 expression to suppress apoptosis pathways and increase rpn5 expression to enhance the activity of proteasomes.

S3270

Genipin 1-O-beta-D-gentiobioside

Genipin 1-O-beta-D-gentiobioside (GG, Genipin 1-β-D-gentiobioside, Genipin 1-gentiobioside, Genipin 1-β-gentiobioside, Genipin gentiobioside) is a bioactive iridoid glycoside isolated from Gardenia jasminoides Ellis (Zhizi in Chinese) that exhibits hepatoprotective, anti-inflammatory, antioxidant, and antithrombotic activities.

S3279

Polyphyllin B (Formosanin C)

Polyphyllin B (Formosanin C, FC), a diosgenin saponin isolated from Paris formosana, is an immunomodulator with antitumor activity. Polyphyllin B (Formosanin C, FC) induces apoptosis.

Oncol Lett, 2021, 22(1):550

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1282	Artemisinin Artemisinin (Qinghaosu, Artemisinine) is a sesquiterpene endoperoxide which is a potent antimalarial agent.	Front Immunol, 2021, 12:634368 Int Immunopharmacol, 2021, 95:107541 Antiviral Res, 2020, 29:104810
S2264	Artemether Artemether (SM-224, CGP 56696) is an antimalarial for the treatment of resistant strains of falciparum malaria.	Hum Cell, 2022, 10.1007/s13577-022-00671-y Sci Rep, 2021, 11(1):14571 Hum Cell, 2021, 34(6):1911-1918	Schistosomicidal effects of PZQ, ART(Artemether) and OXA on 14-day schistosomula. Magnification of the in vitro-cultured schistosomula treated with PZQ, ART, and OXA at 10 μM. Drugs were added at day 14 and schistosomula were analyzed at day 21 (late treatment). 0.1% DMSO in medium (solvent of the drugs; used as negative control) had no effect on schistosomula development.
S2479	Lincomycin HCl Lincomycin hydrochloride (Lincocin, NSC 70731) is the monohydrated salt of lincomycin, a substance produced by the growth of a member of the lincolnensis group of Streptomyces lincolnensis.	Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 10.1007/s13577-021-00639-4 Hum Cell, 2021, 34(6):1911-1918
S1644	Nitrofural Nitrofural (Nitrofurazone) is a topical anti-infective agent with an IC50 of 22.83 ± 1.2 μM. (Rat LD50 = 590 mg/kg)
S4237	Primaquine Diphosphate Primaquine Diphosphate is a transmission-blocking anti-malarial clinically available, displaying a marked activity against gametocytes of all species of human malaria.	Front Pharmacol, 2021, 12:695009 Cell Syst, 2019, 8(2):97-108
S2469	Fleroxacin Fleroxacin (Ro 23-6240, AM-833) is a new broad-spectrum fluoroquinolone.
S3116	Sulfathiazole Sulfathiazole is an organosulfur compound that has been used as a short-acting sulfa drug.
S2511	Sulfadoxine Sulfadoxine (Sulphadoxine) is an ultra-long-lasting sulfonamide with an IC50 of 249 μg/ml for P. vivax.
S3067	Chlorhexidine 2HCl Chlorhexidine hydrochloride (NSC-185) is an antiseptic effective against a wide variety of gram-negative and gram-positive organisms.	BMC Microbiol, 2020, 20(1):275
S4147	Azithromycin Dihydrate Azithromycin Dihydrate is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin.	J Cell Biochem, 2022, 10.1002/jcb.30213 PLoS Comput Biol, 2020, 16(12):e1008489 bioRxiv, 2020, 2020.10.02.324228
S4191	Betamipron Betamipron (CS-443) is a chemical compound which is used together with panipenem to inhibit panipenem uptake into the renal tubule and prevent nephrotoxicity.
S2537	Secnidazole Secnidazole (Flagentyl, PM 185184, RP 14539) is a nitroimidazole anti-infective.
S4195	Broxyquinoline Broxyquinoline is an antiprotozoal agent and able to release oxygen free radicals from the water in mucous membranes.
S4196	Ethacridine lactate monohydrate Ethacridine lactate monohydrate is an aromatic organic compound based on acridine used as an antiseptic agent.	Carcinogenesis, 2014, 35(12):2822-30
S2612	Ribitol Ribitol (Adonitol) is a crystalline pentose alcohol and is formed by the reduction of ribose which is occurs naturally in the plant Adonis vernalis.
S4726	Lauric Acid Lauric Acid (dodecanoic acid, N-Dodecanoic acid, Dodecylic acid) is a saturated medium-chain fatty acid with a 12-carbon backbone. Lauric acid is found naturally in various plant and animal fats and oils, and is a major component of coconut oil and palm kernel oil.
S3288	Absinthin Absinthin (Absynthine) is a naturally produced triterpene lactone from Artemisia absinthium with anti-inflammatory properties. Absinthin significantly enhances the expression of matrix metalloproteinase-8 (MMP-8) and is a possible treatment candidate for Acute lung injury (ALI).
S3941	Pinocembrin Pinocembrin (Dihydrochrysin, Galangin flavanone, 5,7-Dihydroxyflavanone) is a major flavonoid molecule incorporated as multifunctional in the pharmaceutical industry. Its vast range of pharmacological activities has been well researched including antimicrobial, anti-inflammatory, antioxidant, and anticancer activities.	J Neuroinflammation, 2020, 17(1):337
S4573	m-Tolyl acetate m-Tolyl acetate is a pharmaceutical intermediate and antiseptic.
S4579	Resorcinol Resorcinol is a chemical compound that serves as an antiseptic,an disinfectant, and a chemical intermediate for the production of many other pharmaceuticals.
S9564	p-Hydroxy-cinnamic Acid p-Hydroxy-cinnamic Acid has in vitro antimalarial activity and in vivo anti-osteoporotic properties.
S6288	Chlorhexidine diacetate Chlorhexidine diacetate (Hibitane diacetate) is a disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.	BMC Microbiol, 2020, 20(1):275
S5366	Fipronil Fipronil (Fluocyanobenpyrazole, Termidor) is a recalcitrant phenylpyrazole-based pesticide used for flea/tick treatment and termite control that is distributed in urban aquatic environments via stormwater and contributes to stream toxicity.
S9094	Pogostone Pogostone is one of the secondary metabolites from Pogostemon cablin (Blanco) Benth. (Lamiaceae), serving as the effective component of the antimicrobial activity.	J Ethnopharmacol, 2021, 278:114250
S4420	Mefloquine HCl Mefloquine HCl is a blood schizonticide by inhibiting hemozoin formation, used as an antimalarial drug.	Mol Med Rep, 2021, 23(1)40 bioRxiv, 2020, 2020/9/20.4.7.30734 Int J Parasitol Drugs Drug Resist, 2018, 8(2):331-340	BALB/c mice, orally infected with E. multilocularis eggs, were treated by either mefloquine (100 mg/kg twice per week, n = 9), ABZ (200 mg/kg, 5 times per week, n = 8) or control-treated (placebo, n = 9). After 12 weeks of treatment, parasite lesion numbers in the liver were assessed microscopically (A).
S4142	Clopidol Clopidol (WR 61112) is an antiprotozoal agent.
S4592	Captisol (SBE-β-CD) Captisol (SBE-β-CD, Sulfobutylether-β-Cyclodextrin) is a novel, chemically modified cyclodextrin with a structure designed to optimize the solubility and stability of drugs.	Cell Metab, 2022, S1550-4131(22)00083-3 Cell Metab, 2022, 34(1):171-183.e6 Cell, 2021, S0092-8674(21)00690-5
S5700	Phthalylsulfathiazole Phthalylsulfathiazole (Sulfathalidine) is a broad-spectrum antimicrobial that can treat different types of infections including intestinal.
S4041	Olsalazine Sodium Olsalazine Sodium is an anti-inflammatory prodrug, which consists of two 5-ASA moieties linked by an azo bond.	Oncotarget, 2017, 8(1):228-237	Values represent the average scores for each group ± S.E. (N = 10 per group). The differences between individual experimental groups and 17 days DSS only group were statistically significant (p < 0.05) for all groups.
S6136	(±)-α-Bisabolol α-bisabolol is a small, plant-derived, oily sesquiterpene alcohol with some anti-inflammatory and even anti-microbial properties.
S5757	Isoeugenol Isoeugenol (4-Propenylguaiacol), an essential oil constituent of nutmeg, clove, and cinnamon, shows antimicrobial activity.
S4250	Sulfamethoxypyridazine Sulfamethoxypyridazine (CL 13494) is a long-acting sulfonamide for treatment of Dermatitis herpetiformis.
S5397	Chlorhexidine Chlorhexidine is a disinfectant and topical anti-infective agent that is active against Gram-positive and Gram-negative organisms, facultative anaerobes, aerobes, and yeasts.	J Cell Mol Med, 2021, 10.1111/jcmm.16673 BMC Microbiol, 2020, 20(1):275
S6173	Amylmetacresol Amylmetacresol is an antiseptic used to treat infections of the mouth and throat.
S6185	Arachidonic acid Arachidonic acid (Arachidonate) is an unsaturated, essential fatty acid found in animal and human fat as well as in the liver, brain, and glandular organs. It is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes.	Bone Res, 2022, 10(1):20
S2271	Berberine chloride (NSC 646666) Berberine chloride (NSC 646666, Natural Yellow 18) is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.	Front Pharmacol, 2021, 12:632201 Molecules, 2021, 26(5)1210 Biology (Basel), 2021, 10(3)250
S2282	Cinchonidine Cinchonidine is an alkaloid used in asymmetric synthesis in organic chemistry.	J Med Virol, 2019, 91(8):1440-1447
S5475	Novaluron Novaluron (Rimon) belongs to the class of insecticides called insect growth regulators with pesticide properties.
S3218	Amiloxate Amiloxate (Amiloxiate, Isoamyl Methoxycinnamate, Isopentyl 4-methoxycinnamate, Isoamyl 4-methoxycinnamate, Isoamyl p-methoxycinnamate, Isopentyl p-methoxycinnamate) is EMA-approved chemical UV-filter used in cosmetics. Amiloxate is a cinnamic acid derivative with anti-inflammatory activity.
S5963	Sulfathiazole sodium Sulfathiazole sodium, an antimicrobial agent, is an organosulfur compound that has been used as a short-acting sulfa drug.
S5967	Berberine chloride hydrate Berberine (Natural Yellow 18) chloride hydrate is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.	Front Pharmacol, 2021, 12:632201
S4172	Cetylpyridinium Chloride Cetylpyridinium chloride is a cationic quaternary ammonium compound used as oropharyngeal antiseptic.
S6243	Ethyl pyruvate Ethyl pyruvate (CTI-01) is a simple aliphatic ester of pyruvic acid and has been shown to have robust neuroprotective effects via its anti-inflammatory, anti-oxidative, and anti-apoptotic functions.
S3695	Cystamine dihydrochloride Cystamine dihydrochloride (Decarboxycystine, 2-Aminoethyl disulfide, 2,2'-Dithiobisethanamine) acts as an anti-infective agent, which is used in the treatment of urinary tract infections and also as a radiation-protective agent that interferes with sulfhydryl enzymes.
S4175	Sulfaguanidine Sulfaguanidine is a sulfonamide used as an anti-infective agent.
S2395	Rheochrysidin Rheochrysidin (Physcione) is an anthraquinone from roots of Rheum officinale Baill.	ACS Chem Biol, 2015, 10.1021/cb5009487	AmpC β-lactamase and MDH inhibition dose-response curves in the absence (black circles) and presence (red triangles) of DTT for (C and D) physcion.
S3787	Picroside I Picroside I (6'-Cinnamoylcatalpol), an iridoid glycoside, is a hepatoprotective agent which is reported to be antimicrobial and used against hepatitis B.
S9016	Dipsacoside B Dipsacoside B, extracted from the flowerbuds of Lonicera confusa DC, shows strong antimicrobial activity.
S5908	Garenoxacin Garenoxacin (T-3811ME, BMS-284756) is a novel des-F(6) quinolone that has been shown to be effective in vitro against a wide range of clinically important pathogens, including gram-positive and gram-negative aerobes and anaerobes.
S3649	Ceftazidime Ceftazidime is a third-generation cephalosporin that has activity against Gram-negative bacilli, including Pseudomonas aeruginosa.
S4062	Ronidazole Ronidazole is an antiprotozoal agent.
S4971	Buparvaquone Buparvaquone (Butalex) is a second-generation hydroxynaphthoquinone related to parvaquone, with novel features that make it a promising compound for the therapy and prophylaxis of all forms of theileriosis.
S6761	Dalfopristin Dalfopristin (RP54476) is a semi-synthetic analogue of ostreogyrcin A. Quinupristin/dalfopristin (Q/D) is a parental streptogramin with a spectrum of activity that includes Gram-positive pathogens, including those resistant to other classes of antimicrobial compounds.
S4192	Chlorquinaldol Chlorquinaldol is an antimicrobial agent used for local antisepsy.
S5292	Diazolidinyl urea Diazolidinyl urea (Germall II) is an antimicrobial preservative used in cosmetics.
S3210	3'-Hydroxy-4'-methoxyacetophenone 3'-Hydroxy-4'-methoxyacetophenone (Acetoisovanillone, Isoacetovanillone, Diosmin EP Impurity A) is an active P. spinosa extract with anti-inflammatory potential.
S5961	Prednisolone disodium phosphate Prednisolone disodium phosphate (Hydeltrasol, Prednisolone 21-phosphate disodium) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties that exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells.	J Immunotoxicol, 2021, 18(1):154-162 Eur J Rheumatol, 2021, 10.5152/eurjrheum.2021.20054
S5887	Khellin Khellin (Methafrone, Visammin, Ammivisnagen, Khellinorm, Medekellin, Viscardan, Kalangin), a compound isolated from the seeds of Ammi Visnaga Lam (Umbelliferae), is used to treat a variety of maladies.
S4081	Sulfacetamide Sodium Sulfacetamide Sodium is an anti-biotic.	G3 (Bethesda), 2020, 4;10(5):1585-1597
S4759	p-Coumaric Acid p-Coumaric acid (4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, 4-Coumaric acid, Trans-p-Coumaric acid, para-Coumaric Acid) is a hydroxy derivative of cinnamic acid found in a variety of edible plants and is reported to have antioxidant, anti-inflammatory, and antimicrobial activity.	Exp Ther Med, 2021, 21(5):503 J Nutr Biochem, 2015, 26(11):1379-84
S7411	Ascomycin (FK520) Ascomycin (FK520, FR 900520, Immunomycin), an FK-506 analog, is a neutral macrolide immunosuppressant, which prevents rejection after an organ transplant. Phase 3.	Melanoma Res, 2020, 30(4):325-335 Virol Sin, 2019, 34(6):648-661
S0146	Broxaldine Broxaldine (Brobenzoxaldine, AL307) is an antiprotozoal drug and can be used in leprosy.
S6019	2-Phenylphenol 2-Phenylphenol, found in lemon, is an antifungal agent and preservative used in food seasonings.
S9387	Maackiain Maackiain (Demethylpterocarpin) is a pterocarpan that is widely distributed in leguminous plants. It has anticancer and antimicrobial effects.
S3364	3-Hydroxyphenylacetic acid 3-Hydroxyphenylacetic acid (3-HPAA) is a phenolic acid mostly found in olive oil wastewater and an intestinal metabolite of the dietary flavonoid quercetin. 3-Hydroxyphenylacetic acid exhibits antimicrobial properties.
S9084	Rhoifolin Rhoifolin (Rhoifoloside, Apigenin 7-O-neohesperidoside, Apigenin-7-O-rhamnoglucoside), a natural glycoside of apigenin, has been obtained from the green leaves of Rhus succedanea and possesses a variety of significant biological activities including antioxidant, anti-inflammatory, antimicrobial, hepatoprotective and anticancer effects.
S3801	Sodium Houttuyfonate Sodium Houttuyfonate, the active compound of the Houttuynia plant, is mainly used for treating purulent skin infections, respiratory tract infections, including pneumonia in elderly patients, and chronic bronchitis.
S2613	Clorsulon Clorsulon (MK-401) is used in the treatment of Fasciola hepatica infections in calves and sheep.	Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 34(6):1911-1918 Hum Cell, 2021, 10.1007/s13577-021-00579-z
S6442	Chlorphenesin Chlorphenesin is a synthetic preservative used in skin care as a cosmetic biocide.
S9342	1,4-Naphthoquinone 1,4-Naphthoquinone (α-Naphthoquinone, para-naphthoquinone, P-Naphthoquinone), found in diesel exhaust particles and it is an active metabolite of naphthalene, is a fumigant insecticide.
S2564	Cloxacillin Sodium Cloxacillin Sodium is a sodium salt of cloxacillin that is a penicillinase-resistant, acid resistant, semi-synthetic penicillin.
S9112	Kaempferitrin Kaempferitrin (Lespenefril, Lespedin, Lespenephryl, Kaempferol 3,7-dirhamnoside), isolated from the leaves of Hedyotis verticillata and from Onychium japonicum, has antimicrobial, antioxidant, and anti-inflammatory activities.
S5096	SulfadiMethoxine sodium Sulfadimethoxine (Sulfadimethoxydiazine) is a long-lasting sulfonamide antimicrobial agent used to treat many infections including treatment of respiratory, urinary tract, enteric, and soft tissue infections.	Cell Death Dis, 2018, 9(6):646
S9113	Ononin Ononin (Formononetin glucoside, Formononetin 7-O-glucoside) is an isoflavone glycoside with anti-inflammtory effects.
S5099	4-Aminophenylarsonic acid 4-Aminophenylarsonic acid (Arsanilic Acid) is an organoarsenic compound with activity as an anti-infective agent.
S6459	Nifurtimox Nifurtimox (BAY-2502) is an antiprotozoal agent.
S4232	Nithiamide Nithiamide (CL 5279) is a non-5-nitroimidazole drugs.
S3618	Acetylspiramycin (ASPM) Acetylspiramycin (ASPM, Spiramycin II, Foromacidin B) is a macrolide antimicrobial agent.
P1201	LL37 (Human cathelicidin) LL37 (Human cathelicidin, Ropocamptide) is a cathelicidin-related antimicrobial peptide with potent chemotactic and immunomodulatory properties.
S4236	Proflavine Hemisulfate Proflavine Hemisulfate is a topical antiseptic by interchelating DNA, thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands.
S3746	Lumefantrine Lumefantrine (benflumetol) is an antimalarial agent used to treat acute uncomplicated malaria.	Antimicrob Agents Chemother, 2021, AAC.02137-20 ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00522
S5212	Imidazolidinyl Urea Imidazolidinyl Urea (Imidurea) is an antimicrobial agent used as preservative in cosmetics.
S5210	Sulfamethazine Sodium Salt Sulfamethazine (Sulfadimethyldiazine) is a sulfanilamide anti-infective agent used in the lifestock industry.
S0443	Desciclovir Desciclovir (DCV, 6-Deoxyacyclovir, BW A515U) is a prodrug of the antiherpetic agent acyclovir (ACV) that converted into ACV by xanthine oxidase in humans.
S4678	Povidone iodine Povidone iodine (Betadine, PVP iodine, PVP-I, Isodine) is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. It is used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol.
S9131	Punicalagin Punicalagin, a major ellagitannin found in pomegranate extracts, has been shown to have antioxidant, anti-inflammatory, and anticancer effects.	Cell, 2020, 30;181(3):637-652.e15. Cell, 2020, 30;181(3):637-652e15
S3139	Methenamine Methenamine is an antibiotic used for the treatment of urinary tract infection.
S5405	Propylparaben Propylparaben (Propyl 4-hydroxybenzoate, Propyl p-hydroxybenzoate, nipasol), a natural substance found in many plants and some insects, is an antimicrobial, preservative and flavouring agent.
S4242	Cetrimonium Bromide (CTAB) Cetrimonium Bromide (CTAB) is a known component of the broad-spectrum antiseptic cetrimide, which is a mixture of different quaternary ammonium salts.	Biochem Cell Biol, 2021, 10.1139/bcb-2020-0570 Micromachines (Basel), 2018, 9(6)
S5214	Imidocarb dipropionate Imidocarb is an antiprotozoal agent, used as dipropionate in the treatment of babesiosis and ehrlichiosis.	Nat Commun, 2017, 8(1):823
S6461	Permethrin Permethrin is a synthetic Type I pyrethroidal neurotoxic pesticide that has been responsible for accidental animal deaths.
S3978	5-Phenyl-2,4-pentadienoic acid 5-Phenyl-2,4-pentadienoic acid (5-Phenylpenta-2,4-dienoic acid) is used as Synthetic building block, anti-malarial agent.
S3220	Trigonelline Trigonelline (Trigenolline) is a plant alkaloid and a major component of coffee and fenugreek with anti-degranulation, anti-diabetic, antioxidant, anti-inflammatory, and neuroprotective effects. Trigonelline inhibits FcεRI-mediated intracellular signaling pathways, such as phosphorylation of PLCγ1, PI3K, and Akt. Trigonelline (Trigenolline) also inhibits the microtubule formation in RBL-2H3 cells.	Biomed Pharmacother, 2021, 143:112204
S5390	N-(Hytroxymethy)micotinamide N-(Hydroxymethyl)nicotinamide (Nikomethamide, Bilamid, N-hydroxymethylnicotinamide) is an antimicrobial agent.
S5355	Piperaquine phosphate Piperaquine phosphate is an orally active bisquinolone antimalarial drug.
S9560	Anisodamine Hydrobromide Anisodamine (6-Hydroxyhyoscyamine) is a naturally occurring atropine derivative and exhibits anti-inflammatory activity. It also inhibits α1-adrenergic receptors and muscarinic acetylcholine receptors (mAChRs).
S5005	Cefotiam hydrochloride Cefotiam hydrochloride (Halospor, Pansporin, Pansporine) is the hydrochloride salt form of cefotiam and has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.
S1962	Sulphadimethoxine Sulphadimethoxine is a non-reducing glucuronide.
S4555	Carsalam Carsalam (Carbonylsalicylamide) is a nonsteroidal anti-inflammatory drug.
S7896	Sodium Tauroursodeoxycholate (TUDC) Sodium Tauroursodeoxycholate (TUDC) is a water soluble bile salt, used for the treatment of gallstones and liver cirrhosis.	Microbiome, 2019, 7(1):145 Int J Biol Sci, 2019, 15(9):1905-1920 EBioMedicine, 2018, 37:269-280
S4521	DEET DEET (N,N-Diethyl-meta-toluamide, diethyltoluamide) is a commen active ingredient insect repellent.
S9185	Nitidine Chloride Nitidine Chloride, a benzophenanthridine alkaloid found in species of the genus Zanthoxylum, has an anti-malarial activity.	Int Immunopharmacol, 2021, 101(Pt A):108273 Front Cell Neurosci, 2020, 14:216

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Anti-infection製品