TLR

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S4157 Chloroquine Phosphate 100 mg/mL <1 mg/mL '''<1 mg/mL
S8562 CA-4948 <1 mg/mL 30 mg/mL <1 mg/mL
S6573 MD2-IN-1 <1 mg/mL 72 mg/mL 2 mg/mL
S8531 PF-06650833 <1 mg/mL 72 mg/mL 3 mg/mL
S6719 E6446 (dihydrochloride) 100 mg/mL 3 mg/mL 2 mg/mL
S7455 Resatorvid (TAK-242) <1 mg/mL 72 mg/mL '72 mg/mL
S4430 Hydroxychloroquine Sulfate 67 mg/mL <1 mg/mL '<1 mg/mL
S3924 Ginsenoside Rb1 -1 mg/mL 100 mg/mL -1 mg/mL
S8677 Cu-CPT22 <1 mg/mL 72 mg/mL 9 mg/mL
S7221 GS-9620 <1 mg/mL 1 mg/mL <1 mg/mL
S8133 Resiquimod <1 mg/mL 63 mg/mL 21 mg/mL
S7161 Motolimod (VTX-2337) <1 mg/mL 55 mg/mL 15 mg/mL

TLR製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S4157

Chloroquine Phosphate

Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Chloroquine is also an inhibitor of toll-like receptors (TLRs).

S8562

CA-4948

CA-4948 is a reversible kinase inhibitor that modulates IRAK4 function in both the toll-like receptor (TLR) and interleukin 1 receptor (IL-1R) signaling cascades, and demonstrates pharmacodynamic and antitumor activity in in vitro and in vivo nonclinical models.

S6573

MD2-IN-1

MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD value of 189 μM.

S8531

PF-06650833

PF-06650833 is a potent, selective inhibitor of IRAK4 with an IC50 of 0.2 nM.

S6719

E6446 (dihydrochloride)

E6446 is a specific Toll-like receptor 9 inhibitor.

S7455

Resatorvid (TAK-242)

Resatorvid (TAK-242) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α, IL-6, and IL-1β in macrophages with IC50 values of 1-11 nM. Resatorvid inhibits autophagy.

S4430

Hydroxychloroquine Sulfate

Hydroxychloroquine Sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR) 7/9.

S3924

Ginsenoside Rb1

Ginsenoside Rb1 is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions.

S8677

Cu-CPT22

CU-CPT22 shows dose-dependent inhibitory effects blocking Pam3CSK4-induced TLR1/2 activation with an IC50 of 0.58 ± 0.09 µM while no significant inhibition to TLR2/6. It demonstrates minimal non-specific inhibition against a panel of 10 representative kinases (PDGFRB, MET, DDR2, SRC, MAPK1, PAK1, AKT1, PKC-γ, CAMK1, and PLK4).

S7221

GS-9620

GS-9620 is a potent and selective orally active small molecule agonist of Toll-like receptor 7.

S8133

Resiquimod

Resiquimod is an immune response modifier that acts as a potent TLR 7/8 agonist. Phase 2.

S7161

Motolimod (VTX-2337)

Motolimod (VTX-2337) is a selective and potent Toll-like receptor (TLR) 8 agonist with EC50 of 100 nM, > 50-fold selectivity over TLR7. Phase 2.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S4157

Chloroquine Phosphate

Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Chloroquine is also an inhibitor of toll-like receptors (TLRs).

S8562

CA-4948

CA-4948 is a reversible kinase inhibitor that modulates IRAK4 function in both the toll-like receptor (TLR) and interleukin 1 receptor (IL-1R) signaling cascades, and demonstrates pharmacodynamic and antitumor activity in in vitro and in vivo nonclinical models.

S6573

MD2-IN-1

MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD value of 189 μM.

S8531

PF-06650833

PF-06650833 is a potent, selective inhibitor of IRAK4 with an IC50 of 0.2 nM.

S6719

E6446 (dihydrochloride)

E6446 is a specific Toll-like receptor 9 inhibitor.

S7455

Resatorvid (TAK-242)

Resatorvid (TAK-242) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α, IL-6, and IL-1β in macrophages with IC50 values of 1-11 nM. Resatorvid inhibits autophagy.

S4430

Hydroxychloroquine Sulfate

Hydroxychloroquine Sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR) 7/9.

S3924

Ginsenoside Rb1

Ginsenoside Rb1 is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions.

S8677

Cu-CPT22

CU-CPT22 shows dose-dependent inhibitory effects blocking Pam3CSK4-induced TLR1/2 activation with an IC50 of 0.58 ± 0.09 µM while no significant inhibition to TLR2/6. It demonstrates minimal non-specific inhibition against a panel of 10 representative kinases (PDGFRB, MET, DDR2, SRC, MAPK1, PAK1, AKT1, PKC-γ, CAMK1, and PLK4).

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S7221

GS-9620

GS-9620 is a potent and selective orally active small molecule agonist of Toll-like receptor 7.

2020, 179:112987

2019, 10(1):387

2018, 2(8):578-588

S8133

Resiquimod

Resiquimod is an immune response modifier that acts as a potent TLR 7/8 agonist. Phase 2.

2020, 15;8(2):E186

2020, 469:173-185

2019, 10(1):746

S7161

Motolimod (VTX-2337)

Motolimod (VTX-2337) is a selective and potent Toll-like receptor (TLR) 8 agonist with EC50 of 100 nM, > 50-fold selectivity over TLR7. Phase 2.

2020, 1

2020, 179:112987

2020, 4(2):93-107