製品コードS1786 別名:CL 318952

Verteporfin 化学構造


Verteporfin is a small molecule that inhibits TEAD–YAP association and YAP-induced liver overgrowth. It is also a potent second-generation photosensitizing agent derived from porphyrin.

サイズ 価格(税別)  
JPY 53120.00
JPY 161020.00


  • Verteporfin treatment inhibits proliferation and induces apoptosis of Tsc1-null cells in vivo. Mice were administered i.p. with vehicle or verteporfin at a dose of 100 mg/kg every other day for 10 d before sacrifice. Mice were sacrificed at 6 wk of age. Three independent experiments were performed and mice in different treatments were pooled for analysis. Percentage of Ki67 and αSMA double-positive cells in α-SMA+ mesenchymal lesions in the indicated kidneys. Immunofluorescence staining and counting were performed on three sagittal sections from different kidney regions for each mouse.

    J Exp Med 2014 211(11), 2249-63. Verteporfin purchased from Selleck.

    A representative immunostaining results of p-EGFR, p-ERK, YAP1, and cleavage caspase-3 in tumors of each group of nude mice.

    Theranostics, 2017, 7(5):1114-1132. Verteporfin purchased from Selleck.

  • Colony formation in H520 cells and H1581 cells that were with or without verteporfin

    Cancer Lett, 2018, 423:36-46. Verteporfin purchased from Selleck.

    The effects of ADR and Verteporfin on the growth of HCC xenograft derived from MHCC-97H cells (n = 5 for each group). Representative images of IHC staining of KI67 and cleaved caspase-3 in tumors. Scale bar: 100 μm.

    EBioMedicine, 2018, 35:142-154. Verteporfin purchased from Selleck.

  • The indicated cell lines were treated with control (Ctrl) or YAP-targeting siRNAs and growth assessed by XTT proliferation assays at the indicated time points. The mean and +SD are shown for three independent experiments. (Left panel, *, P < 0.05, significantly different from U87Rictor DMSO; Right panel, *, P < 0.05, significantly different from H4Rictor DMSO).

    J Biol Chem, 2015, 290(32): 19387-401 . Verteporfin purchased from Selleck.

    The levels of YAP, phospho-YAP (S127), and its downstream targeted molecules CTGF and CYR61 were analyzed by Western blotting after UM cells were exposed to verteporfin for 24 hours.

    Am J Cancer Res, 2016, 6(12):2816-2830.. Verteporfin purchased from Selleck.




製品説明 Verteporfin is a small molecule that inhibits TEAD–YAP association and YAP-induced liver overgrowth. It is also a potent second-generation photosensitizing agent derived from porphyrin.
VDA [1]
(Endothelial cells)
YAP/TEAD interaction [3]

Verteporfin is about four times more efficient in absorbing light at wavelengths that penetrate tissues best (i.e., around 700 nm) and thus provides a much higher cytotoxic effect than hematoporphyrin (10 times more in human adherent cell lines). Verteporfin is lipophilic and is more readily taken up by malignant or activated cells, compared with normal or resting cells. Verteporfin binds with LDL to form a complex, which is then taken up into proliferating cells (e.g., neovascular endothelial cells) probably via LDL receptors and endocytosis. Verteporfin therapy achieves complete angiographic occlusion of the neovascular compartment by thrombosis of vascular channels, following selective endothelial damage. Verteporfin therapy selectively induces reproducible and isolated choriocapillary occlusion without alteration of overlying photoreceptors or ganglion cells, as shown by light and electron microscopy. [1] Verteporfin conbined with light rapidly exhibits apoptotic changes reflected by caspase-3 and caspase-9 activation and PARP cleavage in HL-60 cells, changes that are blocked by the general caspase inhibitor ZVAD.fmk. [2]

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HL-60 MnvBSpVv[3Srb36gZZN{[Xl? NHHOPJJ,OTByIH7nM41N M3LWNGROW09? M1fqVYlv[3KnYYPld{BFVkFiZoLh[41mdnSjdHnvckBt\X[nbIO= MYOxNFYxPzdzMB?=
HL-60 NFLFZ41kgXSxdH;4bYNqfHliYYPzZZk> NX;Yc4k2hjFyMDDu[{9uVA>? MYXEUXNQ M1jXS4lvcGmkaYTzJINmdGxidnnhZoltcXS7 NEDqeHYyODZyN{exNC=>
Jurkat Mn;vRZBweHSxc3nzJIF{e2G7 NXvmOnRbhjJ6MDDuUS=> MUXEUXNQ NY\5OFl{cW6mdXPld{BiKEKlbD2yMYRmeGWwZHXueEBieG:ydH;zbZM> NIjZVGgyOTJ2NUSxOS=>
RIF-1 MUPGeY5kfGmxbjDhd5NigQ>? NVL0Z5o6OSEQvHevcYw> NUHhSph{TE2VTx?= MkPp[IVkemWjc3XzJI95gWenbjDjc45{fW2ydHnvci=> MlK1NVI3OTV5MUi=
RIF-1 NXXXblZl[3m2b4TvfIlkcXS7IHHzd4F6 M4XwV|Eh|rypL33s MVLEUXNQ NGHxe3Zl\WO{ZXHz[UB1dyB{MDFCtUA2LSClZXzsJJN2en[rdnHs NF7YPYkyOjZzNUexPC=>
SVEC4-10 NUP6OWJQTnWwY4Tpc44h[XO|YYm= MYqyNFAhdmdxbXy= NWPmdG8zTE2VTx?= NGT0[4JqdmS3Y3XzJI1q[3KxdIXieYxmKGSncH;sfY1memm8YYTpc44> Mn7UNVY1PjdzME[=
SVEC4-10 NWXOenpRTnWwY4Tpc44h[XO|YYm= Mmn6NlAxKG6pL33s MVHEUXNQ M3PNSYlv\HWlZYOgd5Rz\XO|IHHjeIlvKG[rYnXyJIZwem2jdHnvci=> MknXNVY1PjdzME[=
ARPE-19 NFHtTXNkgXSxdH;4bYNqfHliYYPzZZk> MVH+NE4yKM7:Zz;tcC=> NWLwR3pwTE2VTx?= M3fJV5Npd3e|IHGg[I9{\S2mZYDlcoRmdnRidH;4bYNqfHl? MUmxOlk5PzlyNR?=
ARPE-19 MWjGeY5kfGmxbjDhd5NigQ>? M{G4cVAvODFizsznM41t M1fpOGROW09? NFHQZXJqdmO{ZXHz[ZMhXkWJRjDhcoQhemWmdXPld{BRTUSIIHX4dJJme3Orb36= M{G3blE3QTh5OUC1
Y-79 Mnn0S5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NF20Wot,OSEQvHevcYw> MoHjSG1UVw>? NYryU|BV\GWlcnXhd4V{KHKndHnuc4Jt[XO2b33hJINmdGxicILvcIln\XKjdHnvci=> MmXONVg2Pzl5NkS=
WERI-Rb1 Ml25S5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MkixglEh|rypL33s NX7pWoRsTE2VTx?= MXvk[YNz\WG|ZYOgdoV1cW6xYnzhd5RwdWFiY3XscEBxem:uaX\ldoF1cW:w NXnBOW5ZOTh3N{m3OlQ>
RB247C3 MV7Hdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NHLldnN,OSEQvHevcYw> MXHEUXNQ M3rk[IRm[3KnYYPld{Bz\XSrbn;icIF{fG:vYTDj[YxtKHC{b3zp[oVz[XSrb36= NXiwVZVHOTh3N{m3OlQ>
RB355 MnK0S5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MXv+NUDPxGdxbXy= NFz6XpVFVVOR MWHk[YNz\WG|ZYOgdoV1cW6xYnzhd5RwdWFiY3XscEBxem:uaX\ldoF1cW:w NGruOHkyQDV5OUe2OC=>
RB383 M3m0U2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NIixUXd,OSEQvHevcYw> MXrEUXNQ MkjB[IVkemWjc3XzJJJmfGmwb3LsZZN1d22jIHPlcIwheHKxbHnm[ZJifGmxbh?= M4S2Z|E5PTd7N{[0
hFibro MnfnZ5l1d3SxeHnjbZR6KGG|c3H5 NV3KRYhMOC53INM1[{9udA>? NV3peYdrTE2VTx?= NFmx[3Rl\WO{ZXHz[ZMhfmmjYnnsbZR6KGK7IEi2MFUm NIDhb40zOzR2MUGxOC=>
pTMC NHfndmNkgXSxdH;4bYNqfHliYYPzZZk> MXywMlUhyrWpL33s NInVOYFFVVOR NXjzUm1G\GWlcnXhd4V{KH[rYXLpcIl1gSCkeTC5Nk46LQ>? MkDoNlM1PDFzMUS=
ARPE-19 MXfjfZRwfG:6aXPpeJkh[XO|YYm= MmnNNE42KML3Zz;tcC=> NYfQT5FoTE2VTx?= MlfN[IVkemWjc3XzJJZq[WKrbHn0fUBjgSB3NT61KS=> MVKyN|Q1OTFzNB?=
Panc-1 MYHHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NX;sUpZ3OTBizszN M1KxUmROW09? Mk\zbY5pcWKrdIOgZ4VtdCCycn;sbYZmemG2aX;u M2S4VVI1ODZ7ME[5
MIA PaCa-2 NVvtO2F6T3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NGjyeY8yOCEQvF2= M3P0TWROW09? MWTpcohq[mm2czDj[YxtKHC{b3zp[oVz[XSrb36= NUDHVWNiOjRyNkmwOlk>
BxPC-3 NGjwZnhIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MkC1NVAh|ryP NYeyeIw5TE2VTx?= M4jCbIlvcGmkaYTzJINmdGxicILvcIln\XKjdHnvckBkd22ybHX0[Yx6 MVOyOFA3QTB4OR?=
SU86.86 MmPUS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MkHHNVAh|ryP MVXEUXNQ MVzpcohq[mm2czDj[YxtKHC{b3zp[oVz[XSrb36gZ49ueGyndHXsfS=> NILTbWczPDB4OUC2PS=>
MCF-7 MXHBeZRweGijZ4mgZZN{[Xl? Mkf0NVAh|ryP NXyxb|lPTE2VTx?= NG\xcXZqdmirYnn0d{Bo\W2laYThZolv\S2rbnT1Z4VlKGG3dH;wbIFogQ>? NETTWmYzPDB4OUC2PS=>
WERI MX3Hdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NYe2[YtJhjFyIN88[{9udA>? NWjhS4xxTE2VTx?= Ml;WbY5pcWKrdIOg[5Jwf3SqIH;mJJJmfGmwb3LsZZN1d22jIHPlcIx{ NHHWVlkzPDh|N{G0Ni=>
WERI NXToZpBDTnWwY4Tpc44h[XO|YYm= MoXaglExKM7:Zz;tcC=> M3nIdmROW09? MlTjZoxw[2u|IHPlcIwh[3mlbHWgdJJw\3Knc4Ppc44> M1\EXVI1QDN5MUSy
Y-79 NVfOelkxTnWwY4Tpc44h[XO|YYm= NFznSVl,OTBizsznM41t MUjEUXNQ M4XLWoJtd2OtczDj[YxtKGO7Y3zlJJBzd2e{ZYPzbY9v NHjETW0zPDh|N{G0Ni=>
Y-79 MnTwSpVv[3Srb36gZZN{[Xl? NEW1SZF,OTBizsznM41t MoDLSG1UVw>? NYPKXYpu[W[oZXP0d{B[SVBvVFXBSEBxem:2bz3vcoNw\2WwZTDwZZRpf2G7 Mn;ZNlQ5OzdzNEK=
Y-79 M1i1OWZ2dmO2aX;uJIF{e2G7 MlnUglExKM7:Zz;tcC=> NFrpOopFVVOR NE\iUFJld3ewLYLl[5Vt[XSnczDwcJVzcXCxdHXuZ5khdWG{a3XyJG9EXC12 NVK3e5VZOjR6M{exOFI>


体内試験 Verteporfin can be used for angiographic visualization of choroidal vessels and CNV, which demonstrates that the photosensitizer accumulates rapidly in experimental CNV in monkeys. Verteporfin accumulates rapidly in the established vasculature of the choroid, RPE, and photoreceptors of rabbit eyes. Verteporfin reaches maximal tissue levels within 3 hours of intravenous injection, followed by a rapid decline within 24 hours in mice. Verteporfin is metabolized to a less active form in vivo and is cleared very rapidly, predominantly in the feces and a very small proportion excreted in urine. Verteporfin therapy effectively and selectively prevents fluorescein dye leakage from experimentally induced CNV in monkeys. [1]


溶解度 (25°C)

体外 DMSO 100 mg/mL (139.12 mM)
Water Insoluble
Ethanol Insoluble

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。


分子量 718.79


CAS No. 129497-78-5
in solvent
別名 CL 318952





質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)


  • 質量





開始濃度 x 開始体積 = 最終濃度 x 最終体積


この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1



  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):




チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2


質量 濃度 体積 分子量


NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03067051 Recruiting Recurrent Prostate Cancer SpectraCure AB March 21 2017 Phase 1
NCT03033225 Recruiting Pancreatic Cancer Non-Resectable Mayo Clinic January 5 2017 Phase 2
NCT02939274 Recruiting Metastatic Breast Cancer Rogers Sciences Inc. October 2016 Phase 2
NCT02702700 Recruiting Pleural Effusion Malignant Centre Hospitalier Universitaire Vaudois January 2016 Phase 1
NCT02495181 Recruiting Polypoidal Choroidal Vasculopathy Association for Innovation and Biomedical Research on Light and Image|European Vision Institute Clinical Research Network January 2016 Phase 4
NCT02457026 Withdrawn Neovascular Age-related Macular Degeneration Duke University|Bausch & Lomb Incorporated January 2016 Not Applicable



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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID