S1786 |
Verteporfin
|
ベルテポルフィン (Verteporfin (CL 318952)) は、TEAD-YAP 相互作用 と YAP による肝肥大を阻害します。 また、ポルフィリンに由来する強力な第 2 世代の光増感剤でもあります。ベルテポルフィンはオートファジー (autophagy) 阻害剤です。 ベルテポルフィンは細胞増殖を阻害し、アポトーシス (apoptosis) を誘導します。 |
-
Bone Res, 2024, 12(1):12
-
Cancer Lett, 2024, 587:216692
-
iScience, 2024, 27(3):109125
|
|
S8661 |
CA3 (CIL56)
|
CA3 (CIL56) has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. CA3(CIL56) induces ferroptosis and iron-dependent reactive oxygen species (ROS). |
-
Cell Rep, 2024, 43(4):114003
-
Nat Commun, 2023, 14(1):6699
-
EMBO Mol Med, 2023, e17187.
|
|
S8164 |
YAP-TEAD Inhibitor 1 (Peptide 17)
|
YAP-TEAD Inhibitor 1 (Peptide 17) is a YAP-TEAD protein-protein interaction inhibitor which has potential usage in treatment of YAP-involved cancers with IC50 of 25 nM. |
-
J Cancer, 2023, 14(13):2562-2573
-
J Cancer, 2023, 14(13):2562-2573
-
Research (Wash D C), 2022, 2022:9825916
|
|
S8554 |
Super-TDU
|
Super-TDU is an inhibitory peptide targeting YAP-TEADs interaction.
|
-
Gut Microbes, 2023, 15(1):2192501
-
Cell Death Discov, 2023, 9(1):424
-
Nat Commun, 2022, 13(1):3117
|
|
S8184New |
Cytochalasin D
|
Cytochalasin D (Zygosporin A, NSC 209835) is a potent actin polymerization inhibitor derived from fungus. Cytochalasin D inhibits actin filament dynamics in cells. It induces phosphorylation and cytoplasmic retention of Yap. |
-
Adv Sci (Weinh), 2023, 10(7):e2205566
-
Research -Wash D C), 2023, 6:0224
-
Research (Wash D C), 2023, 6:0224
|
|
S8951 |
TED-347
|
TED-347 is a potent, irreversible, covalent and allosteric inhibitor of the TEAD⋅Yap protein-protein interaction. TED-347 inhibits TEAD4⋅Yap1 protein-protein interaction with an apparent EC50 of 5.9 μM. |
-
Aging Cell, 2023, e13913.
-
Sci Adv, 2023, 9(28):eadf9460
-
J Med Chem, 2022, 65(13):9206-9229
|
|
S0881 |
Mitochonic acid 5 (MA-5)
|
Mitochonic acid 5 (MA-5) reduces mitochondrial apoptosis via upregulation of mitophagy. Mitochonic acid 5 regulates mitophagy via Bnip3 through the MAPK-ERK-Yap signaling pathway. Mitochonic acid 5 modulates mitochondrial ATP synthesis. |
-
Animals (Basel), 2024, 14(3):368.
-
J Ovarian Res, 2022, 15(1):103
-
Neural Regen Res, 2021, 16(9):1813-1820
|
|
E1314 |
TDI-011536
|
TDI-011536 is a potent Lats kinase inhibitor that interrupts Hippo-Yap signaling and promotes proliferation of lesioned cardiac muscle cells. |
|
|
S9861New |
PY-60
|
PY-60 is a small-molecule activator of the transcriptional coactivator Yes-associated protein (YAP) with EC50 of 1.6 µM, which acts by inhibiting a central scaffolding protein in the Hippo pathway, Annexin A2. It promotes the regenerative repair of cutaneous wounds in pig and human models. |
|
|
E1061 |
TRULI
|
TRULI inhibits both Lats1 and Lats2 with a IC50 of 0.2 nM, suppresses Yap phosphorylation, induces cell proliferation in several cell lines and tissues, and promotes the initial stages of proliferative regeneration of the sensory receptors in the inner ear. |
|
|
E1490New |
IAG933
|
IAG933 (YAP-TEAD-IN-3) is a small molecule and acts as a YAP/TAZ-TEAD inhibitor. It also inhibits NCI-H2052 and can be used in research of tumor invasion and metastatic spread of solid tumors. |
|
|
E1598New |
VT103
|
VT103 is an orally active and selective inhibitor of TEAD1 protein palmitoylation with anti-proliferative and anti-tumor activity. It also inhibits YAP/TAZ-TEAD promoted gene transcription, blocks TEAD auto-palmitoylation and disrupts interaction between YAP/TAZ and TEAD. |
|
|
S1786 |
Verteporfin
|
ベルテポルフィン (Verteporfin (CL 318952)) は、TEAD-YAP 相互作用 と YAP による肝肥大を阻害します。 また、ポルフィリンに由来する強力な第 2 世代の光増感剤でもあります。ベルテポルフィンはオートファジー (autophagy) 阻害剤です。 ベルテポルフィンは細胞増殖を阻害し、アポトーシス (apoptosis) を誘導します。 |
- Bone Res, 2024, 12(1):12
- Cancer Lett, 2024, 587:216692
- iScience, 2024, 27(3):109125
|
|
S8661 |
CA3 (CIL56)
|
CA3 (CIL56) has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. CA3(CIL56) induces ferroptosis and iron-dependent reactive oxygen species (ROS). |
- Cell Rep, 2024, 43(4):114003
- Nat Commun, 2023, 14(1):6699
- EMBO Mol Med, 2023, e17187.
|
|
S8164 |
YAP-TEAD Inhibitor 1 (Peptide 17)
|
YAP-TEAD Inhibitor 1 (Peptide 17) is a YAP-TEAD protein-protein interaction inhibitor which has potential usage in treatment of YAP-involved cancers with IC50 of 25 nM. |
- J Cancer, 2023, 14(13):2562-2573
- J Cancer, 2023, 14(13):2562-2573
- Research (Wash D C), 2022, 2022:9825916
|
|
S8554 |
Super-TDU
|
Super-TDU is an inhibitory peptide targeting YAP-TEADs interaction.
|
- Gut Microbes, 2023, 15(1):2192501
- Cell Death Discov, 2023, 9(1):424
- Nat Commun, 2022, 13(1):3117
|
|
S8184New |
Cytochalasin D
|
Cytochalasin D (Zygosporin A, NSC 209835) is a potent actin polymerization inhibitor derived from fungus. Cytochalasin D inhibits actin filament dynamics in cells. It induces phosphorylation and cytoplasmic retention of Yap. |
- Adv Sci (Weinh), 2023, 10(7):e2205566
- Research -Wash D C), 2023, 6:0224
- Research (Wash D C), 2023, 6:0224
|
|
S8951 |
TED-347
|
TED-347 is a potent, irreversible, covalent and allosteric inhibitor of the TEAD⋅Yap protein-protein interaction. TED-347 inhibits TEAD4⋅Yap1 protein-protein interaction with an apparent EC50 of 5.9 μM. |
- Aging Cell, 2023, e13913.
- Sci Adv, 2023, 9(28):eadf9460
- J Med Chem, 2022, 65(13):9206-9229
|
|
E1314 |
TDI-011536
|
TDI-011536 is a potent Lats kinase inhibitor that interrupts Hippo-Yap signaling and promotes proliferation of lesioned cardiac muscle cells. |
|
|
E1061 |
TRULI
|
TRULI inhibits both Lats1 and Lats2 with a IC50 of 0.2 nM, suppresses Yap phosphorylation, induces cell proliferation in several cell lines and tissues, and promotes the initial stages of proliferative regeneration of the sensory receptors in the inner ear. |
|
|
E1490New |
IAG933
|
IAG933 (YAP-TEAD-IN-3) is a small molecule and acts as a YAP/TAZ-TEAD inhibitor. It also inhibits NCI-H2052 and can be used in research of tumor invasion and metastatic spread of solid tumors. |
|
|
E1598New |
VT103
|
VT103 is an orally active and selective inhibitor of TEAD1 protein palmitoylation with anti-proliferative and anti-tumor activity. It also inhibits YAP/TAZ-TEAD promoted gene transcription, blocks TEAD auto-palmitoylation and disrupts interaction between YAP/TAZ and TEAD. |
|
|
S8184New |
Cytochalasin D
|
Cytochalasin D (Zygosporin A, NSC 209835) is a potent actin polymerization inhibitor derived from fungus. Cytochalasin D inhibits actin filament dynamics in cells. It induces phosphorylation and cytoplasmic retention of Yap. |
- Adv Sci (Weinh), 2023, 10(7):e2205566
- Research -Wash D C), 2023, 6:0224
- Research (Wash D C), 2023, 6:0224
|
|
S9861New |
PY-60
|
PY-60 is a small-molecule activator of the transcriptional coactivator Yes-associated protein (YAP) with EC50 of 1.6 µM, which acts by inhibiting a central scaffolding protein in the Hippo pathway, Annexin A2. It promotes the regenerative repair of cutaneous wounds in pig and human models. |
|
|
E1490New |
IAG933
|
IAG933 (YAP-TEAD-IN-3) is a small molecule and acts as a YAP/TAZ-TEAD inhibitor. It also inhibits NCI-H2052 and can be used in research of tumor invasion and metastatic spread of solid tumors. |
|
|
E1598New |
VT103
|
VT103 is an orally active and selective inhibitor of TEAD1 protein palmitoylation with anti-proliferative and anti-tumor activity. It also inhibits YAP/TAZ-TEAD promoted gene transcription, blocks TEAD auto-palmitoylation and disrupts interaction between YAP/TAZ and TEAD. |
|
|