VDA

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1537 Vadimezan (ASA404) <1 mg/mL 7 mg/mL ''''<1 mg/mL
S1786 Verteporfin (CL 318952) <1 mg/mL 100 mg/mL '''''<1 mg/mL
S1176 Plinabulin (NPI-2358) <1 mg/mL 54 mg/mL <1 mg/mL

VDA製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1537

Vadimezan (ASA404)

Vadimezan (ASA404, NSC 640488, DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-β but relatively low TNF-α expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3.

S1786

Verteporfin (CL 318952)

Verteporfin (CL 318952, Visudyne) is a small molecule that inhibits TEAD–YAP association and YAP-induced liver overgrowth. It is also a potent second-generation photosensitizing agent derived from porphyrin. Verteporfin is an autophagy inhibitor. Verteporfin inhibits cell proliferation and induces apoptosis.

S1176

Plinabulin (NPI-2358)

Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. Phase 1/2.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1537

Vadimezan (ASA404)

Vadimezan (ASA404, NSC 640488, DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-β but relatively low TNF-α expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3.

2021, 13(16)3924

2021, 10(1):1956143

2021, 13(16):20793-20807

S1786

Verteporfin (CL 318952)

Verteporfin (CL 318952, Visudyne) is a small molecule that inhibits TEAD–YAP association and YAP-induced liver overgrowth. It is also a potent second-generation photosensitizing agent derived from porphyrin. Verteporfin is an autophagy inhibitor. Verteporfin inhibits cell proliferation and induces apoptosis.

2021, 10.1038/s41422-021-00477-x

2021, 12(1):3055

2021, 118(29)e2024853118

S1176

Plinabulin (NPI-2358)

Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. Phase 1/2.

2019, 294(20):8161-8170

2019, 96(6):711-719

2013, 5(3):195-212