Afatinib (BIBW2992)

For research use only. Not for use in humans.

製品コードS1011

Afatinib (BIBW2992)化学構造

分子量(MW):485.94

Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.

サイズ 価格(税別) 在庫  
10mM (1mL in DMSO) JPY 41800 あり
JPY 21900 あり
JPY 36800 あり
JPY 96600 あり
JPY 361600 あり
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バルク問合せ

文献中Selleckの製品使用例(186)

製品安全説明書

EGFR阻害剤の選択性比較

生物活性

製品説明 Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.
ターゲット
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
ErbB4 [2]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 1 nM 10 nM 14 nM
体外試験

BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 NGTMWmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwMEC1O|Ih|ryP M3nuSXNCVkeHUh?=
KASUMI-1 MnHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWC5eG56UUN3ME2wMlAxQTFzIN88US=> NUXBemZXW0GQR1XS
HCC2218 M4rSVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwMEC5PFch|ryP NFL3SFlUSU6JRWK=
KARPAS-45 M2r6TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmO0TWM2OD1yLkCxOlcyKM7:TR?= MUPTRW5ITVJ?
HSC-4 NWTrXoxFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvkWlhKSzVyPUCuNFE4PDhizszN NYfFRXVzW0GQR1XS
CHL-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHu4[5BKSzVyPUCuNFE5OzlizszN M2Lq[HNCVkeHUh?=
KY821 NF3OWI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\ze2lEPTB;MD6wNlA3KM7:TR?= NGHncGFUSU6JRWK=
NCI-N87 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTXO2NKSzVyPUCuNFI4PzNizszN NI\6OVVUSU6JRWK=
DOK NEX4RlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHhTWM2OD1yLkCzNVk1KM7:TR?= MWPTRW5ITVJ?
DSH1 NXH4UXJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwMEOzNVQh|ryP MXPTRW5ITVJ?
MDA-MB-175-VII Ml\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMEO0NVYh|ryP NV62S29wW0GQR1XS
NCI-H2170 MkjES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEX5WXJKSzVyPUCuNFM4OjhizszN MVrTRW5ITVJ?
BT-474 NY\iRXh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoH5TWM2OD1yLkC0PVg3KM7:TR?= M130bnNCVkeHUh?=
EFO-27 NH65UmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzuTpJiUUN3ME2wMlA2OTh{IN88US=> NF7OeWVUSU6JRWK=
NCI-H720 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPxRWRIUUN3ME2wMlA2OzJ3IN88US=> MYXTRW5ITVJ?
PC-14 MlrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7GTVdKSzVyPUCuNFU3PjhizszN MVjTRW5ITVJ?
EC-GI-10 M3fWSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3STWM2OD1yLkC1PVEzKM7:TR?= Mn\CV2FPT0WU
KYSE-450 NX;vWZZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfQTWM2OD1yLkC1PVc5KM7:TR?= NYjiN2MxW0GQR1XS
BPH-1 NGTISZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwMEW5PFgh|ryP MXnTRW5ITVJ?
NCI-H292 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIj2NIZKSzVyPUCuNFYxQSEQvF2= MXzTRW5ITVJ?
H9 NYToR5ZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVq2OoM3UUN3ME2wMlA4OTN{IN88US=> NInRUotUSU6JRWK=
NCI-H526 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVGzfnZlUUN3ME2wMlA4QDJ|IN88US=> NWHFd2xEW0GQR1XS
NCI-H1623 NX;vb5Z3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\4TWM2OD1yLkC4NFI2KM7:TR?= MmXUV2FPT0WU
KYSE-140 NGTJZWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33LdWlEPTB;MD6wPFM{KM7:TR?= M2rJWnNCVkeHUh?=
Ca9-22 NYjafZY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fwb2lEPTB;MD6wPFM2OyEQvF2= NHXrSndUSU6JRWK=
AU565 MkDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInTeGhKSzVyPUCuNFg2ODRizszN NFnBclJUSU6JRWK=
ZR-75-30 NG[zSZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1H6VmlEPTB;MD6wPVU1PSEQvF2= MXLTRW5ITVJ?
NCI-H1770 NG\FU2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rx[mlEPTB;MD6xNFI5KM7:TR?= MnSyV2FPT0WU
LB2241-RCC MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwMUC4PFQh|ryP NGG5ZYNUSU6JRWK=
CAL-39 NX\HVY9pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7CTYprUUN3ME2wMlEyPzl{IN88US=> MnPNV2FPT0WU
UACC-893 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrER5dKSzVyPUCuNVE5QDVizszN MorRV2FPT0WU
LU-65 M{W5SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHCSVRpUUN3ME2wMlEzPjN|IN88US=> MkHIV2FPT0WU
HN NXLOXGpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYO1PVlUUUN3ME2wMlE{ODd5IN88US=> NGjlO|FUSU6JRWK=
TI-73 Mn7JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjEUVBKSzVyPUCuNVQ4OTVizszN NUfuUotbW0GQR1XS
KU812 M1n1bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwMUW0OVYh|ryP Mnu0V2FPT0WU
SW13 NUG0UVc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwMU[yNVYh|ryP MVrTRW5ITVJ?
BB30-HNC Mm\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnn1TWM2OD1yLkG2OVc3KM7:TR?= NYXIUVBoW0GQR1XS
HSC-2 M4[4PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmP6TWM2OD1yLkG2PFM4KM7:TR?= MnHxV2FPT0WU
BV-173 NGO5[YtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLxfWp4UUN3ME2wMlE4PTl4IN88US=> Ml\CV2FPT0WU
CAL-27 NXHtenlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHq[GVKSzVyPUCuNVc3OzZizszN NFHKWWFUSU6JRWK=
SBC-1 M4\nRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXmU3JXUUN3ME2wMlE5QTV7IN88US=> NWD0bIZNW0GQR1XS
CAL-33 NFHPRoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXpTWM2OD1yLkKwNVg1KM7:TR?= MUPTRW5ITVJ?
NCI-H209 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmO2TWM2OD1yLkKwOFYh|ryP NHjGSGtUSU6JRWK=
COR-L105 NGrCXlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\hdmlEPTB;MD6yNVA5PCEQvF2= NInHPHdUSU6JRWK=
HSC-3 NIn6b2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLyRo9WUUN3ME2wMlIyOTl6IN88US=> MoH2V2FPT0WU
NCI-H69 NV\rO4pDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mom4TWM2OD1yLkKxOFUyKM7:TR?= MlnhV2FPT0WU
MOLT-13 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwMkO5O|Uh|ryP Mk\MV2FPT0WU
ML-2 MkX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPI[GFoUUN3ME2wMlI1QDB{IN88US=> NWPnblBoW0GQR1XS
IGROV-1 NYXkZYdWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvjT2dQUUN3ME2wMlI2QTV{IN88US=> NH\kNoVUSU6JRWK=
TK10 NGGz[|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnXTWM2OD1yLkK2O|M5KM7:TR?= Mnz2V2FPT0WU
EoL-1-cell NXvOZVJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3MXoVQUUN3ME2wMlI3QDl{IN88US=> MmjyV2FPT0WU
HO-1-N-1 NGrDc|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwMke4OVMh|ryP NX;ZRZN{W0GQR1XS
BHY NVvrfVg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Tp[WlEPTB;MD6yPFY2PSEQvF2= Ml31V2FPT0WU
LU-139 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13qZ2lEPTB;MD6zNFUyKM7:TR?= Mm\rV2FPT0WU
23132-87 Ml:yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTYTWM2OD1yLkOxPVI{KM7:TR?= NH23cFJUSU6JRWK=
ACHN NVzvS3psT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIj6U3lKSzVyPUCuN|E6QTRizszN NIDQc|hUSU6JRWK=
DoTc2-4510 M2PxNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIq5b|BKSzVyPUCuN|IzOTlizszN MkO2V2FPT0WU
BB65-RCC M{DJcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzZWnQ4UUN3ME2wMlM1PTl|IN88US=> NXOyXGxuW0GQR1XS
HLE MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nIe2lEPTB;MD6zOVA1PiEQvF2= MYTTRW5ITVJ?
HCC1419 NX;EdG5qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrITWM2OD1yLkO2OFA5KM7:TR?= MonwV2FPT0WU
A388 MmrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTxWGI6UUN3ME2wMlM3QDV5IN88US=> MWLTRW5ITVJ?
NUGC-3 M4LlNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;E[mlEPTB;MD6zPFM4OyEQvF2= Mkm1V2FPT0WU
KYSE-180 NFr0UZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTPdY5KSzVyPUCuN|kxQDlizszN MUXTRW5ITVJ?
TE-6 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjsSppKSzVyPUCuOFAzPDZizszN NHK0bJhUSU6JRWK=
A498 MnHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXlc3gyUUN3ME2wMlQxPjd2IN88US=> MkjnV2FPT0WU
NCI-H1648 M4frfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2r3dWlEPTB;MD60OFE5OiEQvF2= M2rp[3NCVkeHUh?=
DU-145 NXzFNI1YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3QO3hxUUN3ME2wMlQ1QDN|IN88US=> MkW4V2FPT0WU
CW-2 NYfJW2lKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWG0fZdpUUN3ME2wMlQ3QTF2IN88US=> MXfTRW5ITVJ?
A431 NXPScYVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXRfndKSzVyPUCuOFgzOzNizszN M3HlSnNCVkeHUh?=
SAS MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTGTWM2OD1yLkS4N|k5KM7:TR?= MnrXV2FPT0WU
NCI-H2126 MkjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwNUG5NlYh|ryP MoPYV2FPT0WU
NCI-H358 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDUT4FKSzVyPUCuOVMzOSEQvF2= NVi0PFdXW0GQR1XS
FADU NVLN[mp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHwTWM2OD1yLkW0OFA1KM7:TR?= MYDTRW5ITVJ?
ACN MkG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofFTWM2OD1yLkW1NFk1KM7:TR?= MWjTRW5ITVJ?
HCC70 M4XLT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwNUe2OlEh|ryP MXzTRW5ITVJ?
NCI-H1838 MlvmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwNkCyPVkh|ryP MmLMV2FPT0WU
CAL-54 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELUTIZKSzVyPUCuOlE3OjFizszN MX7TRW5ITVJ?
NCI-H1975 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M121RmlEPTB;MD62NVczQCEQvF2= NHjGdYJUSU6JRWK=
COR-L88 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;rTWlEPTB;MD62OFEyOyEQvF2= Mn;LV2FPT0WU
CTV-1 M3O0SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHWPVZOUUN3ME2wMlY1Ozl{IN88US=> NH6wenNUSU6JRWK=
EW-18 Ml\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmqwTWM2OD1yLk[4Olk5KM7:TR?= M3vRUXNCVkeHUh?=
HCC1806 NHjtT4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPxT5liUUN3ME2wMlY6PjZ4IN88US=> MXzTRW5ITVJ?
HuP-T4 M1XnZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTBwNkm3OkDPxE1? NYj5Soc5W0GQR1XS
MDA-MB-361 M3Xqb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTtV3pKSzVyPUCuO|I3PjJizszN MYDTRW5ITVJ?
NCI-H1573 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHtTWM2OD1yLkezOlMh|ryP M1nTb3NCVkeHUh?=
KU-19-19 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7uXpFKSzVyPUCuO|c1PjRizszN MnTyV2FPT0WU
COLO-678 M3W5PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH:xOINKSzVyPUCuPFA5OzRizszN M4r5dXNCVkeHUh?=
C-33-A NGrxS5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7ncIVKSzVyPUCuPFEzQTdizszN NVTnT2F2W0GQR1XS
Calu-3 M3XvWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwOEG0N|Qh|ryP NH7kVGlUSU6JRWK=
AGS NF;B[49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\q[mlEPTB;MD64N|Y1QCEQvF2= MUHTRW5ITVJ?
SCC-25 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrPTWFKSzVyPUCuPFQyPzFizszN NH;ScVdUSU6JRWK=
JVM-2 M4\CSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWG4TmhnUUN3ME2wMlg5Ojl7IN88US=> NW\URllPW0GQR1XS
HCE-T MoCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXGZodKSzVyPUCuPFg1OjhizszN MmTLV2FPT0WU
ES4 NV[0TWh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLrTWM2OD1yLkm3PFM3KM7:TR?= NH;NUotUSU6JRWK=
EKVX NX7NdXRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4O0T2lEPTB;MT6wNVA3PCEQvF2= NX\F[ZBKW0GQR1XS
D-542MG MnzuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3K3XmlEPTB;MT6wNVA3PCEQvF2= NWrRUIJTW0GQR1XS
SW1116 Mn\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTFwMEGyPFch|ryP MWDTRW5ITVJ?
5637 NFjVSY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\DN2lEPTB;MT6wNVUyKM7:TR?= M2[2UHNCVkeHUh?=
HT-1376 M1joWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7STWM2OD1zLkCxOVE{KM7:TR?= M2\IS3NCVkeHUh?=
NB69 M2XP[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTFwMEK5OFUh|ryP MVfTRW5ITVJ?
YKG-1 NE\PRZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG[5N5NKSzVyPUGuNFU1OTlizszN NGPBe2VUSU6JRWK=
EW-3 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTFwMEe4PFMh|ryP NF3GR2NUSU6JRWK=
GCIY NXfOdnpbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M132OGlEPTB;MT6wPFExPCEQvF2= NWnCOYRiW0GQR1XS
SK-MES-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LXOWlEPTB;MT6xNVQ5PyEQvF2= M1zrfHNCVkeHUh?=
PANC-08-13 NHzFWnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTFwMU[0NVYh|ryP M2XIeXNCVkeHUh?=
SK-NEP-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDTXIdKSzVyPUGuNVc2OTNizszN M{HSZXNCVkeHUh?=
SW954 NVfnTHVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjRTWM2OD1zLkKwNlE1KM7:TR?= NUHTUVlPW0GQR1XS
NCI-SNU-5 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknVTWM2OD1zLkKzPUDPxE1? MXvTRW5ITVJ?
SW48 NV:3OJJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjlSWZiUUN3ME2xMlI2PDN{IN88US=> MVjTRW5ITVJ?
HT-3 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTFwMki3OVMh|ryP M2H4UnNCVkeHUh?=
ETK-1 NHm0ZYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HsTWlEPTB;MT6zO|Q2PiEQvF2= M3nWXXNCVkeHUh?=
SCC-15 M4Dm[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXheJlKSzVyPUGuN|k1PTFizszN NYfH[ZZSW0GQR1XS
DU-4475 NH\6UIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPRTWM2OD1zLkSwNVIyKM7:TR?= M4nTNnNCVkeHUh?=
NB5 Mnu2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkG5TWM2OD1zLkSxN|E4KM7:TR?= NWrx[IMxW0GQR1XS
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SW1710 NEDwPWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHXRWcxUUN3ME24MlE5PTF3IN88US=> NYfv[ZJTW0GQR1XS
D-502MG NXT5UJg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRThwMkmyPFIh|ryP MoXRV2FPT0WU
NCI-H1993 Mlz4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRThwM{O2N|Eh|ryP MVXTRW5ITVJ?
SCC-4 MlP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnUbGRuUUN3ME24MlQ1ODV7IN88US=> NH\1WJlUSU6JRWK=
HAL-01 NWPDb4wyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LNOWlEPTB;OD61NVkyKM7:TR?= NYnl[oNoW0GQR1XS
GT3TKB NHXCPY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRThwNke5OlQh|ryP NHHVfolUSU6JRWK=
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COLO-829 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrwSXNVUUN3ME24MlgxQTd4IN88US=> MlT2V2FPT0WU
OCI-AML2 NGrtdVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rGOmlEPTB;OD65OVQ5OSEQvF2= M{TnS3NCVkeHUh?=
OS-RC-2 M{i3e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rLPGlEPTB;OT6wNlE6KM7:TR?= MV;TRW5ITVJ?
BFTC-909 MkjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETkbmFKSzVyPUmuNFY4QTlizszN NFv0V|lUSU6JRWK=
EW-11 MkLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jM[2lEPTB;OT6xO|Y2OyEQvF2= NV7USlJKW0GQR1XS
HCE-4 M3jCPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn25TWM2OD17LkKxOVU5KM7:TR?= M37YTXNCVkeHUh?=
BALL-1 M3j1Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljNTWM2OD17LkKxPVA4KM7:TR?= M3HG[XNCVkeHUh?=
SF539 NHH2fodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPZTWM2OD17LkKzOVYzKM7:TR?= MXLTRW5ITVJ?
CAMA-1 MlfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fYOGlEPTB;OT6yPFEzQCEQvF2= M1XhenNCVkeHUh?=
C32 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTlwM{OwOlQh|ryP M3\sV3NCVkeHUh?=
NCI-H1703 M13Scmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3UTWM2OD17LkO0N|c2KM7:TR?= NWniXZp1W0GQR1XS
NCI-H1650 MnP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTlwNkC5OFYh|ryP NH7O[ppUSU6JRWK=
NCI-H1563 M{fLS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jlSGlEPTB;OT63OlA{OSEQvF2= MmDSV2FPT0WU
CAL-85-1 NU\oNnpxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPYTWM2OD17Lki3N|g{KM7:TR?= Mmn2V2FPT0WU
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MHH-PREB-1 NU\VUnVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nhdmlEPTB;MUCuNVk6QSEQvF2= NGOzOWFUSU6JRWK=
DEL NWDmdJUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fwemlEPTB;MUCuN|k1PiEQvF2= M{fLVXNCVkeHUh?=
HuCCT1 M3LLeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7ZZYRzUUN3ME2xNE43ODN|IN88US=> NIS5fWxUSU6JRWK=
OVCAR-4 NYrkRZc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorXTWM2OD1zMD64PFM2KM7:TR?= NHP4eIhUSU6JRWK=
CAL-72 Moi3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37XZWlEPTB;MUCuPVM6OSEQvF2= NIOzeYtUSU6JRWK=
HCC1954 M2DVO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTFzLkC3OVQh|ryP NHLUTW9USU6JRWK=
EFO-21 M3XZdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkf6TWM2OD1zMT6xNFQ2KM7:TR?= Ml2zV2FPT0WU
FTC-133 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTFzLkG0NFch|ryP NWjUZox3W0GQR1XS
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UACC-62 MnvYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\lTWM2OD1zMT6yN|Y5KM7:TR?= MU\TRW5ITVJ?
NCI-H650 MlG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLPTWM2OD1zMT6yOFE5KM7:TR?= NEPnU|dUSU6JRWK=
ALL-PO MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HwcGlEPTB;MUGuNlUyOiEQvF2= NWr1c2EzW0GQR1XS
T84 NH[xelJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{mxUGlEPTB;MUGuN|kxPyEQvF2= NFHWeHpUSU6JRWK=
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SW626 NEXMfnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjsTWM2OD1zMT61O|U2KM7:TR?= NHjiTYNUSU6JRWK=
RPMI-2650 Mm\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LSdmlEPTB;MUGuOVg5PSEQvF2= MnXuV2FPT0WU
MC-IXC NHi5e5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3CUXk1UUN3ME2xNU43PzJ6IN88US=> Ml7QV2FPT0WU
HOP-62 NISzc2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTFzLk[3OlQh|ryP NHnkRWRUSU6JRWK=
NOS-1 MkHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTFzLkexNFkh|ryP MYXTRW5ITVJ?
SW1573 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPhTWM2OD1zMT63Nlk2KM7:TR?= MnX0V2FPT0WU
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NCI-H596 NHzoeHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TtUmlEPTB;MUKuNFM3QSEQvF2= MWDTRW5ITVJ?
A172 NXTGTG1tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfKcG13UUN3ME2xNk4xPzl6IN88US=> MUTTRW5ITVJ?
RS4-11 NYrRd25zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DaWmlEPTB;MUKuNVczPSEQvF2= NUHIV2k1W0GQR1XS
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SW837 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrNeIVrUUN3ME2xNk46ODJ6IN88US=> MUfTRW5ITVJ?
NMC-G1 MnTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M335XWlEPTB;MUKuPVI{PCEQvF2= MV;TRW5ITVJ?
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OVCAR-5 M3GyUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1r1PWlEPTB;MUOuNVU6OyEQvF2= MYLTRW5ITVJ?
8505C Ml3US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTF|LkKwOlch|ryP NIPuW2xUSU6JRWK=
SK-MEL-1 MmXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPOTWM2OD1zMz63NVM2KM7:TR?= MkH1V2FPT0WU
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OE33 MnvYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrlTJNKSzVyPUGzMlc5PiEQvF2= MUHTRW5ITVJ?
Ramos-2G6-4C10 M4DUUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTF2LkCyNFIh|ryP MVLTRW5ITVJ?
EW-13 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfFRVk4UUN3ME2xOE4xOzV{IN88US=> MmrUV2FPT0WU
NCI-H1793 MmnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jxcGlEPTB;MUSuNlA5PyEQvF2= NH\zbolUSU6JRWK=
BHT-101 M4fWb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnX[FVKSzVyPUG0MlI1OSEQvF2= NIrvZ5JUSU6JRWK=
RKO MlXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnaUosyUUN3ME2xOE42ODd3IN88US=> MVrTRW5ITVJ?
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PANC-10-05 NG\5SHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{L1fGlEPTB;MUSuOlI1PyEQvF2= M2XBO3NCVkeHUh?=
NCI-H2030 NEW3b|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkT2TWM2OD1zND62OFQ5KM7:TR?= M1jkWXNCVkeHUh?=
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HCC1395 NEf2dZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjjTY1EUUN3ME2xOE46OzN6IN88US=> MUfTRW5ITVJ?
A2058 M1jmWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTF3LkC0NFkh|ryP M3O0T3NCVkeHUh?=
SW1463 M3vkPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnOTWM2OD1zNT6wOFg2KM7:TR?= MoLuV2FPT0WU
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CAL-120 MmnwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYP2XmZKUUN3ME2xOU4yPDR5IN88US=> NUjESmtOW0GQR1XS
COLO-824 MnfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTF3LkG1O|kh|ryP MknhV2FPT0WU
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OVCAR-8 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml2yTWM2OD1zNT64PFYyKM7:TR?= MUjTRW5ITVJ?
MFE-280 M3vHdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTF4LkC0PFgh|ryP MXLTRW5ITVJ?
MHH-NB-11 Mk\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX6wUol[UUN3ME2xOk4xQDN7IN88US=> MVXTRW5ITVJ?
SW1990 NVnsXZpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfRTWM2OD1zNj6xO|U2KM7:TR?= M{TKdHNCVkeHUh?=
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MCF7 M4TTTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mor0TWM2OD1zNj60O|I{KM7:TR?= MoTqV2FPT0WU
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no-10 Mn3rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnj0TWM2OD1zNj62N|Q{KM7:TR?= MYTTRW5ITVJ?
HuP-T3 MkG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmS0TWM2OD1zNj62OVc3KM7:TR?= Mmq4V2FPT0WU
QIMR-WIL M3q2U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTPTVg6UUN3ME2xOk44OTB3IN88US=> NY\iV|MyW0GQR1XS
NCI-H1092 NYe4SXFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVj6UWlyUUN3ME2xOk45OzF4IN88US=> MX7TRW5ITVJ?
MZ2-MEL MlzsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HqcWlEPTB;MU[uPFQxOyEQvF2= NFeyeoFUSU6JRWK=
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COLO-684 M33zR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTF4Lkm0O|ch|ryP MWrTRW5ITVJ?
NCI-H661 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPEcZJKSzVyPUG2Mlk3QTRizszN MVHTRW5ITVJ?
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NCI-H2405 MnviS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3OxN2lEPTB;MUeuNVk4PCEQvF2= NUHCVItTW0GQR1XS
U-2-OS MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7RTWM2OD1zNz61N|A4KM7:TR?= MmrKV2FPT0WU
RERF-LC-MS M33XNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTF5LkW1NFgh|ryP M1fYWXNCVkeHUh?=
NCI-H2342 M4Hxemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTF5LkW1O{DPxE1? M2j5bHNCVkeHUh?=
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MOLT-16 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGO4eWxKSzVyPUG3Mlg6OzRizszN M1flW3NCVkeHUh?=
RH-18 NHjZbpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUj1fYFjUUN3ME2xPE4xODN3IN88US=> MUfTRW5ITVJ?
D-283MED MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\VXmlEPTB;MUiuNFA5QCEQvF2= MkTxV2FPT0WU
RCC10RGB M36yTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPsTWM2OD1zOD6wOVU6KM7:TR?= MoTQV2FPT0WU
NCI-H1437 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTF6LkG2OFEh|ryP NEnnWGZUSU6JRWK=
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A704 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPUTWM2OD1zOD60O|U{KM7:TR?= M1OxW3NCVkeHUh?=
ESS-1 M2O5NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTF6LkWyNFUh|ryP MUTTRW5ITVJ?
SCH Mki3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnYeIJJUUN3ME2xPE43PDV4IN88US=> MXnTRW5ITVJ?
COLO-320-HSR NV3oUWtJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7qdlFKSzVyPUG4Mlc1PiEQvF2= NHvySmpUSU6JRWK=
Mo-T NEGwS2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTF6LkiyNFQh|ryP M3zmfnNCVkeHUh?=
Saos-2 M4\vT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DydGlEPTB;MUmuNVE3OiEQvF2= MV7TRW5ITVJ?
SW684 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTF7LkGzNlYh|ryP M4fMcXNCVkeHUh?=
KMOE-2 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M132dWlEPTB;MUmuNlI1OiEQvF2= NX7QNZVbW0GQR1XS
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NCI-H2122 NW\yW4JST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTN2LkO0O|Eh|ryP MUXTRW5ITVJ?
ABC-1 M2jOfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTN2LkO2PVMh|ryP MYDTRW5ITVJ?
NCI-H1355 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTN2LkO4PFkh|ryP M1\qVXNCVkeHUh?=
NOMO-1 NEfDWVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTN2LkW3NFMh|ryP MV;TRW5ITVJ?
MZ7-mel MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGm2cZFKSzVyPUO0MlY1QDdizszN NV;CVVBmW0GQR1XS
NCI-H810 M2LDU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHhTWM2OD1|ND63Nlc5KM7:TR?= NUizVWlVW0GQR1XS
D-392MG MoHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrXZ5FKSzVyPUO1MlA2PjVizszN MlzWV2FPT0WU
LB771-HNC MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HWfWlEPTB;M{WuNVY2QCEQvF2= NGnRXG1USU6JRWK=
COLO-679 M1rNd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzpV2ZnUUN3ME2zOU4{QDhizszN MWjTRW5ITVJ?
SK-PN-DW M1TPcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zrcWlEPTB;M{WuOFM3QSEQvF2= NWrXeZRpW0GQR1XS
VA-ES-BJ MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInwOG9KSzVyPUO1MlQ3PDlizszN MlX2V2FPT0WU
KNS-42 NFPkeHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTN3LkW4NlYh|ryP M3XiVXNCVkeHUh?=
RVH-421 M2rUc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn24TWM2OD1|NT63OlQ2KM7:TR?= NVTVNXNLW0GQR1XS
P30-OHK M3HFRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17LZ2lEPTB;M{WuPFc2OiEQvF2= MnT5V2FPT0WU
G-402 M2niV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDRTWM2OD1|NT65PFY4KM7:TR?= MYXTRW5ITVJ?
S-117 NUjkWmRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTN4LkOwNFgh|ryP NXLmTYpmW0GQR1XS
RXF393 NGTsdXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfZR2FKSzVyPUO2MlM4QDVizszN NIOyeXBUSU6JRWK=
LCLC-103H MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTN4Lke4NFMh|ryP MXTTRW5ITVJ?
U-118-MG NXv6b2p5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlz3TWM2OD1|Nj64PFQ4KM7:TR?= NVTWSZVpW0GQR1XS
8-MG-BA MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3n2fWlEPTB;M{[uPVQ5OyEQvF2= M3ThOnNCVkeHUh?=
MFH-ino M2nWc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjpTWM2OD1|Nz6zN|cyKM7:TR?= NFrnZm9USU6JRWK=
NCI-H23 NGG2XpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTtcoRwUUN3ME2zO{41OTl4IN88US=> Mn32V2FPT0WU
NCI-H446 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTN5LkS4OlIh|ryP M2K4SHNCVkeHUh?=
LU-99A NV\pW2p{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XnWGlEPTB;M{euOVc{OSEQvF2= MYPTRW5ITVJ?
KP-N-YN MmT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITmbWdKSzVyPUO3MlYyQTVizszN NV3oSo1YW0GQR1XS
SCC-9 M3:0S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\jcXpKSzVyPUO3Mlc5OzhizszN MoHZV2FPT0WU
EFM-19 NIn1UmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjIcHRKSzVyPUO3Mlc6PjdizszN M3LjVHNCVkeHUh?=
A427 M3n2NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfmcFBKSzVyPUO3MlkyODdizszN NV7wdIFRW0GQR1XS
LB831-BLC NHzQPGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;rRoVkUUN3ME2zPE43ODN7IN88US=> NIDydYlUSU6JRWK=
HOS NGHDdVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTN7Lk[yO|Mh|ryP NGHWWFFUSU6JRWK=
LAN-6 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvufFFoUUN3ME20NE4xOTF{IN88US=> NUjsU3N{W0GQR1XS
U251 NYWzb2JxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTRyLkSwOVQh|ryP MUjTRW5ITVJ?
SNU-387 NUHkXVVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEf1cmVKSzVyPUSwMlQ2PTNizszN MniwV2FPT0WU
DMS-79 MoW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HTV2lEPTB;NECuOVg5QSEQvF2= MmjkV2FPT0WU
SK-LU-1 NX;HWoFHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnUNFRqUUN3ME20NE43PTZ6IN88US=> MojaV2FPT0WU
HT M2fPcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHvNm1KSzVyPUSwMlY3OzlizszN M{HCbXNCVkeHUh?=
KP-N-YS Mmm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILXcWhKSzVyPUSwMlY4PjhizszN M2LxZ3NCVkeHUh?=
DMS-114 NUnZRXZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\hTWM2OD12MD64N|c1KM7:TR?= NI\rPVBUSU6JRWK=
HUTU-80 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrye5ZDUUN3ME20NU4xPTZ7IN88US=> NXL1cHFVW0GQR1XS
ONS-76 M336bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXk[JlKSzVyPUSxMlQ4ODlizszN MUfTRW5ITVJ?
A673 NWrs[mRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPtTWM2OD12MT61NVU4KM7:TR?= M1;VRXNCVkeHUh?=
HPAF-II NGfMV4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;4TWM2OD12MT62O|A6KM7:TR?= M1\mcXNCVkeHUh?=
UACC-257 MnzsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;rXGlEPTB;NEGuO|M3QSEQvF2= NYS3S4poW0GQR1XS
EW-22 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\WOWlEPTB;NEGuPFY6PyEQvF2= NH\jPVVUSU6JRWK=
NCI-H1755 NV;MNIFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jBbWlEPTB;NEGuPFczPSEQvF2= M4S5TXNCVkeHUh?=
KYSE-150 M2PMbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHoTWM2OD12Mj6xO|gzKM7:TR?= Mnz6V2FPT0WU
CGTH-W-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIi3d29KSzVyPUSyMlQ6PTVizszN MoTvV2FPT0WU
NB13 NH;I[5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTR{Lk[yNVch|ryP MVXTRW5ITVJ?
SW872 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHPTWM2OD12Mj62N|MyKM7:TR?= MUHTRW5ITVJ?
KP-4 NHjmS3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnYOm53UUN3ME20Nk45QDN{IN88US=> Ml32V2FPT0WU
HCC38 NV62UZdJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjGXFRKSzVyPUSyMlk3OThizszN NG\sclRUSU6JRWK=
BB49-HNC NVSzcoxQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjYNYRKSzVyPUSzMlI{PTZizszN M4TyO3NCVkeHUh?=
CAL-62 M1HiWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TDNmlEPTB;NEOuOFAzQCEQvF2= NXrRWJZLW0GQR1XS
NCI-H2029 MkjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;TTWM2OD12Mz61OVgyKM7:TR?= MV3TRW5ITVJ?
M14 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TFSGlEPTB;NESuNVM{OiEQvF2= MoLhV2FPT0WU
COLO-680N M{\O[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jhfGlEPTB;NESuN|M6KM7:TR?= MmLLV2FPT0WU
Hs-578-T NInjc3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoC4TWM2OD12NT6wNlk1KM7:TR?= NHHEemNUSU6JRWK=
MSTO-211H MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XyW2lEPTB;NEWuPVQ5OiEQvF2= NXPCU2U3W0GQR1XS
EW-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXndFJKSzVyPUS1Mlk3QDlizszN MX\TRW5ITVJ?
SW948 M{jwOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHGTWM2OD12Nj60OFYzKM7:TR?= MUnTRW5ITVJ?
NCI-H460 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTR4LkWyN{DPxE1? M2fBU3NCVkeHUh?=
CAS-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn63TWM2OD12Nj63O|AyKM7:TR?= NF\Ne|lUSU6JRWK=
TGBC11TKB MkHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfZdJVKSzVyPUS3MlE4PzdizszN MXrTRW5ITVJ?
HD-MY-Z M4PZXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTR6Lke4OkDPxE1? M2fzTHNCVkeHUh?=
NCI-H226 MlXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfJdJFRUUN3ME20PU44Pzh3IN88US=> MnfQV2FPT0WU
PA-1 NVnLcnUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGH3XXNKSzVyPUS5Mlg{OzVizszN NYC1enJLW0GQR1XS
LB2518-MEL NH;JW2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3nOItDUUN3ME20PU45PzJ|IN88US=> M4\0XXNCVkeHUh?=
A101D NXq3c4h4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTR7Lkm0NlUh|ryP MVfTRW5ITVJ?
NCI-H2087 NEn0[|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rXWWlEPTB;NEmuPVY5OiEQvF2= M4\2ZnNCVkeHUh?=

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

アッセイ
Methods Test Index PMID
Western blot
CIP2A / p-AKT / AKT / PARP; 

PubMed: 25537503     


Time-dependent effects of afatinib on CIP2A, p-AKT and apoptosis-related proteins in the sensitive H358 and resistant H460 cells. Cells were exposed to 10 μM afatinib for up to 48 hours. Immunoblots were scanned and quantitated to determine the ratio of the level of CIP2A to actin. Data are mean ± SD. n = 3 for the different time intervals.

p-EGFR / p-IGF1R / p-ERK / p-AKT; 

PubMed: 26052929     


Effects of afatinib on EGFR and IGF1R Signaling Pathways. H1975 cells were treated with afatinib with various doses and cell lysates were subjected to Western blot analysis. Afatinib effectively inhibits p-EGFR and p-ERK while p-AKT was partially inhibited. IGF1R phosphorylation was increased upon afatinib treatment in H1975 cells.

p-VEGFR2 / VEGFR2 / JAG1 / DLL4 / NICD1 ; 

PubMed: 28533486     


HUVECs were cultured in the presence of Vatalanib (100 nM) or DBZ (10 nM) for 1 h and then treated for 15 min with rhgal-3 (37 nM) and cultured for additional 6 hrs. After this period, the total protein was isolated and the protein levels of galectin-3, NICD1, DLL4, JAG1, VEGFR2 and VEGFR2-p were assessed by Western blot. β-actin was used as a loading control.

25537503 26052929 28533486
Growth inhibition assay
Cell apoptosis; 

PubMed: 25537503     


Dose-dependent effects of afatinib on apoptosis. Data are mean ± SD. n = 3 for each concentration. *, p < 0.05, **, p < 0.01, vs. no afatinib. 

Cell viability; 

PubMed: 26515464     


A. MTS assay for Ba/F3 cells harboring EGFR exon 19 deletion and L858R. The proportional cell viability is shown. B. MTS assay for Ba/F3 cells harboring EGFR exon 19 deletion+T790M and L858R+T790M. The proportional cell viability is shown. C. MTS assay for Ba/F3 cells harboring wild type EGFR. The proportional cell viability is shown. Erlotinib, afatinib, osimertinib, and rociletinib were used as EGFR-TKIs. Error bars indicate standard deviation.

25537503 26515464
Immunofluorescence
p65; 

PubMed: 26317651     


Effects of different treatments on the nuclear translocation of the NF-κB subunit p65. A2780T cells were treated with 2.5 μM afatinib for 48 hours, or 10 μM PDTC for 2 hours. Subsequently, the NF-κB subunit p65 (red) was localized by immunofluorescence and a confocal microscopy. Nuclei were stained with DAPI (blue). Scale bar = 10 μM.

vacuoles; 

PubMed: 29713246     


Autophagy activation upon treatment with Afatinib and Sorafenib was validated using immunofluorescence in order to visualize a creation of autophagosomes; ×60 magnification. DMSO treatment was used as control. Green—autophagy vacuoles; Blue—Hoechst, nuclear staining. 

26317651 29713246
体内試験 Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]

お薦めの試験操作(参考用のみ)

キナーゼ試験:

[1]

- 合併

In vitro kinase activity assays:

The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.
細胞試験:

[1]

- 合併
  • 細胞株: NSCLC cells
  • 濃度: 0-10 μM
  • 反応時間: 1 hour
  • 実験の流れ:

    1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.


    (参考用のみ)
動物試験:

[1]

- 合併
  • 動物モデル: Athymic NMRI-nu/nu female mice
  • 投薬量: 20 mg/kg
  • 投与方法: Oral administration
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
混合させたのち直ちに使用することを推奨します。
10mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 485.94
化学式

C24H25ClFN5O3

CAS No. 439081-18-2
保管
in solvent
別名 N/A
Smiles CN(C)C/C=C/C(=O)NC1=CC2=C(NC3=CC=C(F)C(=C3)Cl)N=CN=C2C=C1OC4CCOC4

投与溶媒組成計算器(クリア溶液)

ステップ1:実験データを入力してください。(余分な消耗を考慮し動物一匹分の量を用意することをお勧めします。)
投与量 mg/kg 動物平均体重 g 投与体積(動物毎) ul 動物数
ステップ2:投与溶媒の組成を入力してください。(ロットごとに組成が異なるため、セレックから完全に溶解できる組成をお求めください。)
% DMSO % % Tween 80 % ddH2O
計算リセット

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (mg) = 濃度 (mM) x 体積 (mL) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04206787 Not yet recruiting Drug: Afatinib Non-squamous Non-Small Cell Lung Cancer Boehringer Ingelheim May 6 2020 --
NCT04158947 Recruiting Drug: Afatinib|Drug: T-DM1 HER2-positive Breast Cancer|Brain Metastases xuexin he|Second Affiliated Hospital School of Medicine Zhejiang University May 10 2020 Phase 2
NCT03711422 Not yet recruiting Drug: Afatinib Non-small Cell Lung Cancer|Leptomeningeal Disease|Central Nervous System Metastases National Cancer Centre Singapore October 2018 Phase 1
NCT03083678 Recruiting Drug: Afatinib Chordoma Leiden University Medical Center|Chordoma Foundation|Boehringer Ingelheim June 21 2018 Phase 2
NCT03370770 Completed Drug: Afatinib|Drug: Osimertinib Carcinoma Non-Small-Cell Lung Boehringer Ingelheim December 28 2017 --
NCT02423525 Recruiting Drug: Afatinib Brain Cancer Santosh Kesari|Boehringer Ingelheim|John Wayne Cancer Institute December 2016 Phase 1

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答:

    For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

EGFRシグナル伝達経路

EGFR Inhibitors with Unique Features

相関EGFR製品

Tags: Afatinib (BIBW2992)を買う | Afatinib (BIBW2992) ic50 | Afatinib (BIBW2992)供給者 | Afatinib (BIBW2992)を購入する | Afatinib (BIBW2992)費用 | Afatinib (BIBW2992)生産者 | オーダーAfatinib (BIBW2992) | Afatinib (BIBW2992)化学構造 | Afatinib (BIBW2992)分子量 | Afatinib (BIBW2992)代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID