Afatinib (BIBW2992)

製品コードS1011

Afatinib (BIBW2992)化学構造

分子量(MW):485.94

Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.

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JPY 39840.00
JPY 19920.00
JPY 34860.00
JPY 94620.00
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文献中Selleckの製品使用例(61)

製品安全説明書

EGFR阻害剤の選択性比較

生物活性

製品説明 Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.
ターゲット
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
ErbB4 [2]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 1 nM 10 nM 14 nM
体外試験

BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 NWPGTo9FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrSTWM2OD1yLkCwOVczKM7:TR?= MU\TRW5ITVJ?
KASUMI-1 MlO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37XWWlEPTB;MD6wNFkyOSEQvF2= NI[5V2VUSU6JRWK=
HCC2218 M4jhVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rabGlEPTB;MD6wNFk5PyEQvF2= Ml7sV2FPT0WU
KARPAS-45 NUnMV3ZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvBSZJKSzVyPUCuNFE3PzFizszN NWTYWHE3W0GQR1XS
HSC-4 NWrxdFZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rUOmlEPTB;MD6wNVc1QCEQvF2= MV7TRW5ITVJ?
CHL-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTDTWM2OD1yLkCxPFM6KM7:TR?= M4fw[nNCVkeHUh?=
KY821 NHXzZpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XiUWlEPTB;MD6wNlA3KM7:TR?= NVf3T3l1W0GQR1XS
NCI-N87 M4DNd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnxZXVKSzVyPUCuNFI4PzNizszN NHj1bFlUSU6JRWK=
DOK M4LCcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfoTWM2OD1yLkCzNVk1KM7:TR?= NVzNWFBTW0GQR1XS
DSH1 NGTnflVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mle4TWM2OD1yLkCzN|E1KM7:TR?= M2qzWnNCVkeHUh?=
MDA-MB-175-VII M4HXV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfQTWM2OD1yLkCzOFE3KM7:TR?= NH2z[FNUSU6JRWK=
NCI-H2170 NXjPW5ZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwMEO3Nlgh|ryP M3jPOnNCVkeHUh?=
BT-474 NYjwPGVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwMES5PFYh|ryP M2mxS3NCVkeHUh?=
EFO-27 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVK4eVVUUUN3ME2wMlA2OTh{IN88US=> NHX0cY9USU6JRWK=
NCI-H720 NYTSdHp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYn2RVFZUUN3ME2wMlA2OzJ3IN88US=> MXPTRW5ITVJ?
PC-14 NXzSN|ZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMEW2Olgh|ryP MlzlV2FPT0WU
EC-GI-10 Mmi4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHkRplKSzVyPUCuNFU6OTJizszN NFvs[mRUSU6JRWK=
KYSE-450 NGjHbHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorsTWM2OD1yLkC1PVc5KM7:TR?= Moj3V2FPT0WU
BPH-1 M{e1Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvZSmFKSzVyPUCuNFU6QDhizszN NWjObXZ[W0GQR1XS
NCI-H292 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M363U2lEPTB;MD6wOlA6KM7:TR?= M2OxdHNCVkeHUh?=
H9 Mn;QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrU[WFKSzVyPUCuNFcyOzJizszN Mo\UV2FPT0WU
NCI-H526 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXWc|FkUUN3ME2wMlA4QDJ|IN88US=> NXrqVJptW0GQR1XS
NCI-H1623 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvYTWM2OD1yLkC4NFI2KM7:TR?= MVjTRW5ITVJ?
KYSE-140 MkLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDhbWdvUUN3ME2wMlA5OzNizszN MkfOV2FPT0WU
Ca9-22 M13UbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfSdZdRUUN3ME2wMlA5OzV|IN88US=> MoDSV2FPT0WU
AU565 MmOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2O3N2lEPTB;MD6wPFUxPCEQvF2= NF3zeIJUSU6JRWK=
ZR-75-30 M4LD[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHL1VJlKSzVyPUCuNFk2PDVizszN MoHCV2FPT0WU
NCI-H1770 MoDwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwMUCyPEDPxE1? NUXpfY9PW0GQR1XS
LB2241-RCC M1L2d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrPTWM2OD1yLkGwPFg1KM7:TR?= MUPTRW5ITVJ?
CAL-39 MnvXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NImy[GVKSzVyPUCuNVE4QTJizszN MkO5V2FPT0WU
UACC-893 NXr2e2tFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwMUG4PFUh|ryP NFSwc4NUSU6JRWK=
LU-65 M3\DRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwMUK2N|Mh|ryP NIPTPVBUSU6JRWK=
HN NUTEe|Z3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwMUOwO|ch|ryP NXL1ZW06W0GQR1XS
TI-73 NFrmfW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rpdGlEPTB;MD6xOFcyPSEQvF2= NIXvPZZUSU6JRWK=
KU812 M3n2NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIm3PW5KSzVyPUCuNVU1PTZizszN Moe4V2FPT0WU
SW13 NIDOUo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrsTWM2OD1yLkG2NlE3KM7:TR?= NULuWoc1W0GQR1XS
BB30-HNC M4Hy[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTkTWM2OD1yLkG2OVc3KM7:TR?= M2jCdHNCVkeHUh?=
HSC-2 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17JN2lEPTB;MD6xOlg{PyEQvF2= NEPRSlJUSU6JRWK=
BV-173 MkjyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3v1bGlEPTB;MD6xO|U6PiEQvF2= MYnTRW5ITVJ?
CAL-27 NWHZbnJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M374cGlEPTB;MD6xO|Y{PiEQvF2= M3LnfXNCVkeHUh?=
SBC-1 NFrhZo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1:0W2lEPTB;MD6xPFk2QSEQvF2= M2\0[HNCVkeHUh?=
CAL-33 NHPCOWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfRfFZKSzVyPUCuNlAyQDRizszN MYjTRW5ITVJ?
NCI-H209 M33aZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHoSGI6UUN3ME2wMlIxPDZizszN NGX1WJBUSU6JRWK=
COR-L105 MlPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LTR2lEPTB;MD6yNVA5PCEQvF2= NEX6OodUSU6JRWK=
HSC-3 MofKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XycWlEPTB;MD6yNVE6QCEQvF2= M{fEeHNCVkeHUh?=
NCI-H69 NYrCfG5ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwMkG0OVEh|ryP MUHTRW5ITVJ?
MOLT-13 MoLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPPTWM2OD1yLkKzPVc2KM7:TR?= NWjqO3BCW0GQR1XS
ML-2 NWDvUnpZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjqO|lmUUN3ME2wMlI1QDB{IN88US=> Mn:wV2FPT0WU
IGROV-1 M3\0V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXVbJVJUUN3ME2wMlI2QTV{IN88US=> MkDKV2FPT0WU
TK10 NFjVNlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnMcoxKSzVyPUCuNlY4OzhizszN MVrTRW5ITVJ?
EoL-1-cell MmPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3iwfGlEPTB;MD6yOlg6OiEQvF2= MWPTRW5ITVJ?
HO-1-N-1 NEjQRoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMke4OVMh|ryP MnjuV2FPT0WU
BHY NHS5d29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMki2OVUh|ryP MUjTRW5ITVJ?
LU-139 NXXpWVc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvSVlF3UUN3ME2wMlMxPTFizszN M1jOWnNCVkeHUh?=
23132-87 NYXqfmNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HK[mlEPTB;MD6zNVkzOyEQvF2= MVTTRW5ITVJ?
ACHN NFj5WmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DtPWlEPTB;MD6zNVk6PCEQvF2= NGf1O21USU6JRWK=
DoTc2-4510 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PpUWlEPTB;MD6zNlIyQSEQvF2= NX;ONWxJW0GQR1XS
BB65-RCC Mo\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTBwM{S1PVMh|ryP MnS4V2FPT0WU
HLE MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;sVmlEPTB;MD6zOVA1PiEQvF2= M2P1OnNCVkeHUh?=
HCC1419 NITieWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4W4PGlEPTB;MD6zOlQxQCEQvF2= M2jtdHNCVkeHUh?=
A388 NWP1bWRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETSbGNKSzVyPUCuN|Y5PTdizszN M1XLNXNCVkeHUh?=
NUGC-3 MnziS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwM{izO|Mh|ryP MnyyV2FPT0WU
KYSE-180 NUDqT|ZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\NZ5RrUUN3ME2wMlM6ODh7IN88US=> M2PiTnNCVkeHUh?=
TE-6 MkmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwNECyOFYh|ryP MUfTRW5ITVJ?
A498 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHzbpZLUUN3ME2wMlQxPjd2IN88US=> Mon4V2FPT0WU
NCI-H1648 M4LGeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwNESxPFIh|ryP NISwWIdUSU6JRWK=
DU-145 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnYeHZ[UUN3ME2wMlQ1QDN|IN88US=> NF;hWmZUSU6JRWK=
CW-2 Mn34S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwNE[5NVQh|ryP NXjSdFVIW0GQR1XS
A431 MnLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUD1dVkyUUN3ME2wMlQ5OjN|IN88US=> NFGwWlJUSU6JRWK=
SAS NVrTd|NIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rWS2lEPTB;MD60PFM6QCEQvF2= NFLwR29USU6JRWK=
NCI-H2126 M1u1Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4P4NWlEPTB;MD61NVkzPiEQvF2= NITSPGlUSU6JRWK=
NCI-H358 MmC1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XyeWlEPTB;MD61N|IyKM7:TR?= NYDFfZJ6W0GQR1XS
FADU NH30R5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkj4TWM2OD1yLkW0OFA1KM7:TR?= M{jOenNCVkeHUh?=
ACN NITkSI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPke5dtUUN3ME2wMlU2ODl2IN88US=> M3;MNXNCVkeHUh?=
HCC70 NXXqd3NZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwNUe2OlEh|ryP MoPNV2FPT0WU
NCI-H1838 M4fLbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLWTWM2OD1yLk[wNlk6KM7:TR?= MnnpV2FPT0WU
CAL-54 NF\2dVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwNkG2NlEh|ryP M124eHNCVkeHUh?=
NCI-H1975 MlPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFGweFNKSzVyPUCuOlE4OjhizszN MYnTRW5ITVJ?
COR-L88 M4TYSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVOwZXVHUUN3ME2wMlY1OTF|IN88US=> M{LVW3NCVkeHUh?=
CTV-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XZPWlEPTB;MD62OFM6OiEQvF2= M{TQXHNCVkeHUh?=
EW-18 MofNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfkTJJKSzVyPUCuOlg3QThizszN MV;TRW5ITVJ?
HCC1806 NW\Y[G5bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TUVGlEPTB;MD62PVY3PiEQvF2= NUPnfFh[W0GQR1XS
HuP-T4 NEnoR2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVmwcI9mUUN3ME2wMlY6PzZizszN MnixV2FPT0WU
MDA-MB-361 NWPEZVE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PZOmlEPTB;MD63NlY3OiEQvF2= NUTEWXg3W0GQR1XS
NCI-H1573 NWjwS|V{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHq3WmtKSzVyPUCuO|M3OyEQvF2= M1OyZ3NCVkeHUh?=
KU-19-19 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLFZpk2UUN3ME2wMlc4PDZ2IN88US=> MmSwV2FPT0WU
COLO-678 NHLqSFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jESGlEPTB;MD64NFg{PCEQvF2= NF7lR|dUSU6JRWK=
C-33-A MlLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTBwOEGyPVch|ryP NV7XfJNoW0GQR1XS
Calu-3 NWHhTWFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwOEG0N|Qh|ryP M1LHbHNCVkeHUh?=
AGS MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nHU2lEPTB;MD64N|Y1QCEQvF2= MX;TRW5ITVJ?
SCC-25 NG\0empIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvJS3RKSzVyPUCuPFQyPzFizszN MYnTRW5ITVJ?
JVM-2 Ml\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrTXWJpUUN3ME2wMlg5Ojl7IN88US=> MonoV2FPT0WU
HCE-T NYXBfXkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\HRWlEPTB;MD64PFQzQCEQvF2= NVS3OHRIW0GQR1XS
ES4 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvSTWM2OD1yLkm3PFM3KM7:TR?= MVnTRW5ITVJ?
EKVX MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVj0cXRbUUN3ME2xMlAyODZ2IN88US=> MlTUV2FPT0WU
D-542MG NUjUeHlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITkeVZKSzVyPUGuNFExPjRizszN NH7JbZNUSU6JRWK=
SW1116 M4jB[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvqTWM2OD1zLkCxNlg4KM7:TR?= NIPUe2xUSU6JRWK=
5637 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{SzV2lEPTB;MT6wNVUyKM7:TR?= MoDIV2FPT0WU
HT-1376 NYnTR5hKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXuybVI6UUN3ME2xMlAyPTF|IN88US=> M3HQTnNCVkeHUh?=
NB69 NVTIOZhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHZ[GZEUUN3ME2xMlAzQTR3IN88US=> M{HLVnNCVkeHUh?=
YKG-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTFwMEW0NVkh|ryP M{DaPHNCVkeHUh?=
EW-3 MnHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3ifY9KSzVyPUGuNFc5QDNizszN MnP4V2FPT0WU
GCIY NHjPb4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnf3TWM2OD1zLkC4NVA1KM7:TR?= NVLVc|BjW0GQR1XS
SK-MES-1 MnLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjVbFhUUUN3ME2xMlEyPDh5IN88US=> MmfBV2FPT0WU
PANC-08-13 NVmyOGN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTFwMU[0NVYh|ryP NELkd4NUSU6JRWK=
SK-NEP-1 MlXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;uV3ROUUN3ME2xMlE4PTF|IN88US=> NV;CTFI{W0GQR1XS
SW954 NIfvNZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnLPFhKSzVyPUGuNlAzOTRizszN M1GzXXNCVkeHUh?=
NCI-SNU-5 NEHZZ2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTmXoYyUUN3ME2xMlI{QSEQvF2= NHH4VHJUSU6JRWK=
SW48 NEG1T3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17ke2lEPTB;MT6yOVQ{OiEQvF2= NInsTVJUSU6JRWK=
HT-3 M3zoS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjSUVRKSzVyPUGuNlg4PTNizszN NYfuO3pDW0GQR1XS
ETK-1 M{WzUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWX6e3h6UUN3ME2xMlM4PDV4IN88US=> MlH6V2FPT0WU
SCC-15 Mn7NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPGUlVSUUN3ME2xMlM6PDVzIN88US=> NXi2S2xoW0GQR1XS
DU-4475 NFX1[IVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\he2RvUUN3ME2xMlQxOTJzIN88US=> NWe4SWFZW0GQR1XS
NB5 NVnuc5RxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV:4eJhUUUN3ME2xMlQyOzF5IN88US=> MoPoV2FPT0WU
CFPAC-1 MlHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2K2S2lEPTB;MT60NlQ6OyEQvF2= NGjyOHFUSU6JRWK=
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KYSE-410 NFfwVndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\SeXJPUUN3ME2xMlY2Pjd{IN88US=> MX3TRW5ITVJ?
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LB1047-RCC NVXGR4VpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3lSpdlUUN3ME2yMlc1QDh6IN88US=> Ml7uV2FPT0WU
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RPMI-7951 MmDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fGXGlEPTB;Mz6wO|U6KM7:TR?= MW\TRW5ITVJ?
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NCI-H2009 NW[3SJh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HDRWlEPTB;Mz62NVIyPiEQvF2= NYK0c3JVW0GQR1XS
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BT-20 MnfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2n1WmlEPTB;Mz62PVc6PSEQvF2= NFLoXnhUSU6JRWK=
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NCI-H1693 NVnhOVgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7zWnU5UUN3ME2zMlg1OThzIN88US=> NYrBfng3W0GQR1XS
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RPMI-8226 Mkm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrCO3F6UUN3ME20MlEyPjNzIN88US=> M1[xR3NCVkeHUh?=
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EPLC-272H MlfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmP2TWM2OD12LkSxOVM{KM7:TR?= MkLxV2FPT0WU
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CTB-1 NGPWcWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnpTWM2OD12Lki0PFgh|ryP MnqzV2FPT0WU
HL-60 MmDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfZ[4QxUUN3ME20Mlg3PjFzIN88US=> MoXMV2FPT0WU
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MEG-01 M32yO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DK[GlEPTB;ND65PVQxOyEQvF2= MVjTRW5ITVJ?
KYSE-520 NW\KcnRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYH1SGpoUUN3ME21MlIxQDN7IN88US=> M37tdXNCVkeHUh?=
HuO-3N1 Ml\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTVwMkSwOFMh|ryP MluwV2FPT0WU
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TE-5 NIfxUo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTVwNEC4OUDPxE1? MU\TRW5ITVJ?
NCI-H747 MnPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nOeGlEPTB;NT60NlQ4OiEQvF2= NW\WSnQxW0GQR1XS
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HC-1 M3zVcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjqPW5tUUN3ME21MlUyQDN7IN88US=> M{LaOHNCVkeHUh?=
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KINGS-1 MmqyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTVwNkC5OFQh|ryP NXHk[GVQW0GQR1XS
D-423MG NF;0VJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rFeGlEPTB;NT62NVcxPSEQvF2= M3TiPHNCVkeHUh?=
SW962 NVTlcFJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjxVGh[UUN3ME21MlYzODN{IN88US=> MkLtV2FPT0WU
LOXIMVI NGPRdXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13ue2lEPTB;NT62N|g4OyEQvF2= NFnlSVNUSU6JRWK=
LS-411N MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnjUm5RUUN3ME21Mlc6PDRzIN88US=> NFnFdGJUSU6JRWK=
NCI-H2291 M{H3Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37ibWlEPTB;NT65PFk1OyEQvF2= MlvRV2FPT0WU
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NB14 MojoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HnTmlEPTB;Nj60N|g{PiEQvF2= M3G5W3NCVkeHUh?=
NCI-H1299 MlztS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTZwNkOxO|Eh|ryP M3y2bnNCVkeHUh?=
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DJM-1 MlToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLwV4hDUUN3ME22MlkzODF{IN88US=> M1S4VHNCVkeHUh?=
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NCI-H28 M4XDO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDZXZFsUUN3ME23MlE3PDB3IN88US=> MVnTRW5ITVJ?
MN-60 NYjnZnZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkX0TWM2OD15LkK4NFg6KM7:TR?= MWDTRW5ITVJ?
RMG-I MnK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWj3ZmJkUUN3ME23MlM6Ojl4IN88US=> M{nVcnNCVkeHUh?=
COLO-800 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGW1d3hKSzVyPUeuOFE1PDZizszN MnjaV2FPT0WU
DB MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzXfXNuUUN3ME23MlYyODB3IN88US=> MkDPV2FPT0WU
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HEL M2Kx[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33KVWlEPTB;Nz63NVIxOyEQvF2= NXm3PFN6W0GQR1XS
NH-12 M4O1NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXLR21mUUN3ME23MlczQDB6IN88US=> NVy1dpo6W0GQR1XS
LB373-MEL-D NX;SV2lsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\PTWM2OD15Lke2O|cyKM7:TR?= NHj4ZmxUSU6JRWK=
SW900 MnrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknHTWM2OD15LkiyNVIyKM7:TR?= M2LKUXNCVkeHUh?=
JVM-3 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1SwWmlEPTB;Nz64PVU6QSEQvF2= MmfDV2FPT0WU
OAW-28 Ml\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\CTWM2OD15Lkm0OVc5KM7:TR?= NWnoTmozW0GQR1XS
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BALL-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmexTWM2OD17LkKxPVA4KM7:TR?= M1nrR3NCVkeHUh?=
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NCI-H1703 MoLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XUUWlEPTB;OT6zOFM4PSEQvF2= M{HwO3NCVkeHUh?=
NCI-H1650 NUHmTY9XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTsS3NZUUN3ME25MlYxQTR4IN88US=> MojnV2FPT0WU
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HuCCT1 Mn7SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3QVWtKSzVyPUGwMlYxOzNizszN MYnTRW5ITVJ?
OVCAR-4 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfNW24zUUN3ME2xNE45QDN3IN88US=> MUfTRW5ITVJ?
CAL-72 MlLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPaOVlsUUN3ME2xNE46OzlzIN88US=> MUnTRW5ITVJ?
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UACC-62 M4\DWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVu4UJFZUUN3ME2xNU4zOzZ6IN88US=> NXrESJpRW0GQR1XS
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OVCAR-5 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\zTWM2OD1zMz6xOVk{KM7:TR?= M4XRV3NCVkeHUh?=
8505C MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrRN4hbUUN3ME2xN{4zODZ5IN88US=> M{nzR3NCVkeHUh?=
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NCI-H1793 Mm\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTF2LkKwPFch|ryP NITpPG5USU6JRWK=
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C2BBe1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\zN|NKSzVyPUG0Mlc3PCEQvF2= NHr2dG5USU6JRWK=
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OVCAR-8 MnWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mle3TWM2OD1zNT64PFYyKM7:TR?= M{HBWnNCVkeHUh?=
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NCI-H2405 Mn[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLPTWM2OD1zNz6xPVc1KM7:TR?= M2i0fXNCVkeHUh?=
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NCI-H1437 NWDoSIx{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvzV|dVUUN3ME2xPE4yPjRzIN88US=> MWrTRW5ITVJ?
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Mo-T MmnVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7YbnZXUUN3ME2xPE45OjB2IN88US=> MY\TRW5ITVJ?
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NOMO-1 NHTiWpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnj0TWM2OD1|ND61O|A{KM7:TR?= Mkj5V2FPT0WU
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NCI-H810 M1vUXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLwSWtKSzVyPUO0MlczPzhizszN Mkf5V2FPT0WU
D-392MG MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlG1TWM2OD1|NT6wOVY2KM7:TR?= NV[1OoxKW0GQR1XS
LB771-HNC NEfPOlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTN3LkG2OVgh|ryP MVfTRW5ITVJ?
COLO-679 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTN3LkO4PEDPxE1? MoPvV2FPT0WU
SK-PN-DW MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzHTWM2OD1|NT60N|Y6KM7:TR?= M{L0O3NCVkeHUh?=
VA-ES-BJ M1fZSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFSwXZJKSzVyPUO1MlQ3PDlizszN M{faO3NCVkeHUh?=
KNS-42 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTN3LkW4NlYh|ryP NIezVG5USU6JRWK=
RVH-421 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGOx[|ZKSzVyPUO1Mlc3PDVizszN MofSV2FPT0WU
P30-OHK NFzIfnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vaSmlEPTB;M{WuPFc2OiEQvF2= NEPJNnNUSU6JRWK=
G-402 NUG1e5J[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvzdHlOUUN3ME2zOU46QDZ5IN88US=> NWnqZVdvW0GQR1XS
S-117 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIezTldKSzVyPUO2MlMxODhizszN Mlm2V2FPT0WU
RXF393 M3zOOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M165S2lEPTB;M{[uN|c5PSEQvF2= M4PFcnNCVkeHUh?=
LCLC-103H MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\ad4dKSzVyPUO2Mlc5ODNizszN M13JRnNCVkeHUh?=
U-118-MG NELGfZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jhc2lEPTB;M{[uPFg1PyEQvF2= MYfTRW5ITVJ?
8-MG-BA MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7jc5J4UUN3ME2zOk46PDh|IN88US=> NUPwRYV4W0GQR1XS
MFH-ino MnPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfQe2pKSzVyPUO3MlM{PzFizszN MnrLV2FPT0WU
NCI-H23 NEHFNoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTN5LkSxPVYh|ryP NFTGbXpUSU6JRWK=
NCI-H446 NFW2[mNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLUVmlyUUN3ME2zO{41QDZ{IN88US=> M2S4NHNCVkeHUh?=
LU-99A MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3sfWNKSzVyPUO3MlU4OzFizszN M4LieXNCVkeHUh?=
KP-N-YN NYrn[pVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvMRZloUUN3ME2zO{43OTl3IN88US=> MX7TRW5ITVJ?
SCC-9 MmLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTN5Lke4N|gh|ryP MXzTRW5ITVJ?
EFM-19 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvBTWM2OD1|Nz63PVY4KM7:TR?= MWHTRW5ITVJ?
A427 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXO2SWlNUUN3ME2zO{46OTB5IN88US=> M3PsbXNCVkeHUh?=
LB831-BLC NUfnRWhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrpc25KSzVyPUO4MlYxOzlizszN NHzj[ZVUSU6JRWK=
HOS NEK4eGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFK1V3dKSzVyPUO5MlYzPzNizszN M3G2cHNCVkeHUh?=
LAN-6 NILPWXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTOTWM2OD12MD6wNVEzKM7:TR?= NF;aeGVUSU6JRWK=
U251 M{DHOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTkTWM2OD12MD60NFU1KM7:TR?= NEfLZXpUSU6JRWK=
SNU-387 M2X4Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLw[lZKSzVyPUSwMlQ2PTNizszN NGqyOmpUSU6JRWK=
DMS-79 MnXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXyU2JKSzVyPUSwMlU5QDlizszN Mm\IV2FPT0WU
SK-LU-1 M4naZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfSN5FPUUN3ME20NE43PTZ6IN88US=> NXzESYd6W0GQR1XS
HT M3vnSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTRyLk[2N|kh|ryP MWLTRW5ITVJ?
KP-N-YS MojPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWe0VGJoUUN3ME20NE43PzZ6IN88US=> MkfRV2FPT0WU
DMS-114 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXHTWM2OD12MD64N|c1KM7:TR?= MnfQV2FPT0WU
HUTU-80 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjlZmVZUUN3ME20NU4xPTZ7IN88US=> M3zOTXNCVkeHUh?=
ONS-76 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3OTWM2OD12MT60O|A6KM7:TR?= NUTWNYxoW0GQR1XS
A673 M132NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTRzLkWxOVch|ryP NF\pU5BUSU6JRWK=
HPAF-II NFnzfoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTRzLk[3NFkh|ryP MYjTRW5ITVJ?
UACC-257 M1zMOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPmWnlKSzVyPUSxMlc{PjlizszN NV7TRWlNW0GQR1XS
EW-22 NU[xUYp6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLKTWM2OD12MT64Olk4KM7:TR?= MYLTRW5ITVJ?
NCI-H1755 MkXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTs[lVKSzVyPUSxMlg4OjVizszN NYPpSXRPW0GQR1XS
KYSE-150 NVL5NHZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvTc2lKSzVyPUSyMlE4QDJizszN NYDoU2ZWW0GQR1XS
CGTH-W-1 Mmm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PNWmlEPTB;NEKuOFk2PSEQvF2= Mnn1V2FPT0WU
NB13 NFO2SWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HkXmlEPTB;NEKuOlIyPyEQvF2= M4DxeXNCVkeHUh?=
SW872 M2fKdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoCxTWM2OD12Mj62N|MyKM7:TR?= MWTTRW5ITVJ?
KP-4 NYTkem1VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTR{Lki4N|Ih|ryP MnvXV2FPT0WU
HCC38 MoqyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\U[W1KSzVyPUSyMlk3OThizszN MVLTRW5ITVJ?
BB49-HNC MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{m5U2lEPTB;NEOuNlM2PiEQvF2= NXTDNVV4W0GQR1XS
CAL-62 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHhTWM2OD12Mz60NFI5KM7:TR?= NFfNVZFUSU6JRWK=
NCI-H2029 MnjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPaNVRKSzVyPUSzMlU2QDFizszN Mn\iV2FPT0WU
M14 Ml3rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTR2LkGzN|Ih|ryP NHnqZpNUSU6JRWK=
COLO-680N MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTR2LkOzPUDPxE1? NHvPRWVUSU6JRWK=
Hs-578-T NX\LRolDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7iTWM2OD12NT6wNlk1KM7:TR?= NYK4fXJrW0GQR1XS
MSTO-211H NWHGc4xxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnu2TWM2OD12NT65OFgzKM7:TR?= NUHsPXhHW0GQR1XS
EW-1 NHTuSodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1T5V2lEPTB;NEWuPVY5QSEQvF2= MlnyV2FPT0WU
SW948 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjreYhZUUN3ME20Ok41PDZ{IN88US=> MWXTRW5ITVJ?
NCI-H460 MljxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;wR2lEPTB;NE[uOVI{KM7:TR?= Mn3ZV2FPT0WU
CAS-1 MmfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTR4Lke3NFEh|ryP NFf6O4ZUSU6JRWK=
TGBC11TKB MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjtOoJKSzVyPUS3MlE4PzdizszN M2qzZXNCVkeHUh?=
HD-MY-Z NGm0S4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\sU3NKSzVyPUS4Mlc5PiEQvF2= NHnDVldUSU6JRWK=
NCI-H226 M4j3Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTR7Lke3PFUh|ryP MoXnV2FPT0WU
PA-1 NIrVN3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTR7LkizN|Uh|ryP NGXER5ZUSU6JRWK=
LB2518-MEL MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXzU2ZKSzVyPUS5Mlg4OjNizszN NY\Gfm5yW0GQR1XS
A101D NFXjVnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;pU2lEPTB;NEmuPVQzPSEQvF2= NVT6Z4J2W0GQR1XS
NCI-H2087 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzVNHpDUUN3ME20PU46Pjh{IN88US=> NHnFS3lUSU6JRWK=

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

アッセイ
Methods Test Index PMID
Western blot
CIP2A / p-AKT / AKT / PARP; 

PubMed: 25537503     


Time-dependent effects of afatinib on CIP2A, p-AKT and apoptosis-related proteins in the sensitive H358 and resistant H460 cells. Cells were exposed to 10 μM afatinib for up to 48 hours. Immunoblots were scanned and quantitated to determine the ratio of the level of CIP2A to actin. Data are mean ± SD. n = 3 for the different time intervals.

p-EGFR / p-IGF1R / p-ERK / p-AKT; 

PubMed: 26052929     


Effects of afatinib on EGFR and IGF1R Signaling Pathways. H1975 cells were treated with afatinib with various doses and cell lysates were subjected to Western blot analysis. Afatinib effectively inhibits p-EGFR and p-ERK while p-AKT was partially inhibited. IGF1R phosphorylation was increased upon afatinib treatment in H1975 cells.

25537503 26052929
Growth inhibition assay
Cell apoptosis; 

PubMed: 25537503     


Dose-dependent effects of afatinib on apoptosis. Data are mean ± SD. n = 3 for each concentration. *, p < 0.05, **, p < 0.01, vs. no afatinib. 

Cell viability; 

PubMed: 26515464     


A. MTS assay for Ba/F3 cells harboring EGFR exon 19 deletion and L858R. The proportional cell viability is shown. B. MTS assay for Ba/F3 cells harboring EGFR exon 19 deletion+T790M and L858R+T790M. The proportional cell viability is shown. C. MTS assay for Ba/F3 cells harboring wild type EGFR. The proportional cell viability is shown. Erlotinib, afatinib, osimertinib, and rociletinib were used as EGFR-TKIs. Error bars indicate standard deviation.

25537503 26515464
Immunofluorescence
p65; 

PubMed: 26317651     


Effects of different treatments on the nuclear translocation of the NF-κB subunit p65. A2780T cells were treated with 2.5 μM afatinib for 48 hours, or 10 μM PDTC for 2 hours. Subsequently, the NF-κB subunit p65 (red) was localized by immunofluorescence and a confocal microscopy. Nuclei were stained with DAPI (blue). Scale bar = 10 μM.

vacuoles; 

PubMed: 29713246     


Autophagy activation upon treatment with Afatinib and Sorafenib was validated using immunofluorescence in order to visualize a creation of autophagosomes; ×60 magnification. DMSO treatment was used as control. Green—autophagy vacuoles; Blue—Hoechst, nuclear staining. 

26317651 29713246
体内試験 Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]

お薦めの試験操作(参考用のみ)

キナーゼ試験:

[1]

+ 展開

In vitro kinase activity assays:

The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.
細胞試験:

[1]

+ 展開
  • 細胞株: NSCLC cells
  • 濃度: 0-10 μM
  • 反応時間: 1 hour
  • 実験の流れ:

    1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.


    (参考用のみ)
動物試験:

[1]

+ 展開
  • 動物モデル: Athymic NMRI-nu/nu female mice
  • 製剤: In 0.5% methocellulose-0.4% polysorbate-80 (Tween 80)
  • 投薬量: 20 mg/kg
  • 投与方法: Oral administration
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
混合させたのち直ちに使用することを推奨します。
10mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 485.94
化学式

C24H25ClFN5O3

CAS No. 439081-18-2
保管
in solvent
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03878524 Not yet recruiting Breast Cancer|Prostate Cancer|Pancreatic Cancer|Acute Myelogenous Leukemia OHSU Knight Cancer Institute|Oregon Health and Science University|Prospect Creek Foundation March 14 2019 Phase 1
NCT03878524 Not yet recruiting Breast Cancer|Prostate Cancer|Pancreatic Cancer|Acute Myelogenous Leukemia OHSU Knight Cancer Institute|Oregon Health and Science University|Prospect Creek Foundation March 14 2019 Phase 1
NCT03827070 Recruiting Non Small Cell Lung Cancer Center Trials & Treatment Europe|Center Trials & Treatment March 5 2019 Phase 1
NCT03827070 Recruiting Non Small Cell Lung Cancer Center Trials & Treatment Europe|Center Trials & Treatment March 5 2019 Phase 1
NCT03727724 Active not recruiting Carcinoma Non-Small-Cell Lung The Netherlands Cancer Institute|Boehringer Ingelheim|Merck Serono International SA December 4 2018 Phase 2
NCT03727724 Active not recruiting Carcinoma Non-Small-Cell Lung The Netherlands Cancer Institute|Boehringer Ingelheim|Merck Serono International SA December 4 2018 Phase 2

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答:

    For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

EGFRシグナル伝達経路

EGFR Inhibitors with Unique Features

相関EGFR製品

Tags: Afatinib (BIBW2992)を買う | Afatinib (BIBW2992) ic50 | Afatinib (BIBW2992)供給者 | Afatinib (BIBW2992)を購入する | Afatinib (BIBW2992)費用 | Afatinib (BIBW2992)生産者 | オーダーAfatinib (BIBW2992) | Afatinib (BIBW2992)化学構造 | Afatinib (BIBW2992)分子量 | Afatinib (BIBW2992)代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID