Afatinib (BIBW2992)

For research use only. Not for use in humans.

製品コードS1011

Afatinib (BIBW2992)化学構造

CAS No. 850140-72-6

Afatinib (BIBW2992) inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively. Afatinib induces autophagy.

サイズ 価格(税別) 在庫  
10mM (1mL in DMSO) JPY 41800 あり
JPY 21900 あり
JPY 36800 あり
JPY 96600 あり
JPY 361600 あり
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バルク問合せ

文献中Selleckの製品使用例(231)

製品安全説明書

EGFR阻害剤の選択性比較

生物活性

製品説明 Afatinib (BIBW2992) inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively. Afatinib induces autophagy.
ターゲット
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
ErbB4 [2]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 1 nM 10 nM 14 nM
体外試験

BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 NIDEZoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwMEC1O|Ih|ryP NWnl[JdYW0GQR1XS
KASUMI-1 NYPYdWZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMEC5NVEh|ryP NHzoWYdUSU6JRWK=
HCC2218 NIfpPIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PxSWlEPTB;MD6wNFk5PyEQvF2= MYnTRW5ITVJ?
KARPAS-45 NXLHcVFST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXXTWM2OD1yLkCxOlcyKM7:TR?= MXPTRW5ITVJ?
HSC-4 NWXDNGV6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\OeHZjUUN3ME2wMlAyPzR6IN88US=> NUH2cGt1W0GQR1XS
CHL-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fJWmlEPTB;MD6wNVg{QSEQvF2= NUfGWYtIW0GQR1XS
KY821 M1zGN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHy1bYVKSzVyPUCuNFIxPiEQvF2= MUDTRW5ITVJ?
NCI-N87 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\XZW4{UUN3ME2wMlAzPzd|IN88US=> MXTTRW5ITVJ?
DOK NV;0fGZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYr2SGFpUUN3ME2wMlA{OTl2IN88US=> MX;TRW5ITVJ?
DSH1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnqTWM2OD1yLkCzN|E1KM7:TR?= MmHJV2FPT0WU
MDA-MB-175-VII MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\yOmlEPTB;MD6wN|QyPiEQvF2= NHH3XlZUSU6JRWK=
NCI-H2170 NHfXfIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXKbYJPUUN3ME2wMlA{PzJ6IN88US=> M4fiNHNCVkeHUh?=
BT-474 NVG5d|NYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnhUZZ2UUN3ME2wMlA1QTh4IN88US=> MXzTRW5ITVJ?
EFO-27 M4jabGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwMEWxPFIh|ryP NHzXVZhUSU6JRWK=
NCI-H720 NIDiRlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXLTWM2OD1yLkC1N|I2KM7:TR?= MWjTRW5ITVJ?
PC-14 NYnMenhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMEW2Olgh|ryP NX\DbWp4W0GQR1XS
EC-GI-10 NILy[lVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HESmlEPTB;MD6wOVkyOiEQvF2= MV\TRW5ITVJ?
KYSE-450 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWGzcWNxUUN3ME2wMlA2QTd6IN88US=> MmfRV2FPT0WU
BPH-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwMEW5PFgh|ryP M1TOb3NCVkeHUh?=
NCI-H292 NUHSXWpzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmf1TWM2OD1yLkC2NFkh|ryP NXLpRYdSW0GQR1XS
H9 NUnlOXR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jONmlEPTB;MD6wO|E{OiEQvF2= Mkm0V2FPT0WU
NCI-H526 M2Hpdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXuU2pVUUN3ME2wMlA4QDJ|IN88US=> NX32fYx5W0GQR1XS
NCI-H1623 MonKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMEiwNlUh|ryP M3HPbHNCVkeHUh?=
KYSE-140 NVfteZJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjZRZN3UUN3ME2wMlA5OzNizszN NFX6XIRUSU6JRWK=
Ca9-22 MmrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7qRYtKSzVyPUCuNFg{PTNizszN NFTwdWZUSU6JRWK=
AU565 NF7aeYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jKbGlEPTB;MD6wPFUxPCEQvF2= M4e3WXNCVkeHUh?=
ZR-75-30 NHnSdpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGm5dm9KSzVyPUCuNFk2PDVizszN M4nLUXNCVkeHUh?=
NCI-H1770 NEXmRXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7tWlBKSzVyPUCuNVAzQCEQvF2= NI\YcZFUSU6JRWK=
LB2241-RCC NHTz[GNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfYTWM2OD1yLkGwPFg1KM7:TR?= NYLJV|UzW0GQR1XS
CAL-39 M{ThdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMUG3PVIh|ryP MYjTRW5ITVJ?
UACC-893 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzyXHRKSzVyPUCuNVE5QDVizszN NUHQdJp2W0GQR1XS
LU-65 NY\JZ2s4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLITWM2OD1yLkGyOlM{KM7:TR?= MVzTRW5ITVJ?
HN MorBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF63ZpVKSzVyPUCuNVMxPzdizszN M3HrOnNCVkeHUh?=
TI-73 NGLM[FdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHYR4VnUUN3ME2wMlE1PzF3IN88US=> NWTSOZlsW0GQR1XS
KU812 NWK2e3pbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvSXIJGUUN3ME2wMlE2PDV4IN88US=> M3f6bHNCVkeHUh?=
SW13 NEDnfWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXNTWM2OD1yLkG2NlE3KM7:TR?= MXTTRW5ITVJ?
BB30-HNC MnnCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTnTWM2OD1yLkG2OVc3KM7:TR?= M1[0SHNCVkeHUh?=
HSC-2 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XjeWlEPTB;MD6xOlg{PyEQvF2= NFPRd|BUSU6JRWK=
BV-173 NIP3b|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMUe1PVYh|ryP M123UXNCVkeHUh?=
CAL-27 Mn;CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDSTWM2OD1yLkG3OlM3KM7:TR?= NETPZ5JUSU6JRWK=
SBC-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3GTWM2OD1yLkG4PVU6KM7:TR?= NV7JTJBWW0GQR1XS
CAL-33 M3fiZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPyTWM2OD1yLkKwNVg1KM7:TR?= Mme3V2FPT0WU
NCI-H209 NX7kRlg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XXPGlEPTB;MD6yNFQ3KM7:TR?= NHzEe4pUSU6JRWK=
COR-L105 NEnsNIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3G1PWlEPTB;MD6yNVA5PCEQvF2= M13E[3NCVkeHUh?=
HSC-3 NH;1[4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFWw[HVKSzVyPUCuNlEyQThizszN NX\Be3ZOW0GQR1XS
NCI-H69 NUH1RnZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITUU4hKSzVyPUCuNlE1PTFizszN M17ZWnNCVkeHUh?=
MOLT-13 NF25foFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwMkO5O|Uh|ryP M3LsfHNCVkeHUh?=
ML-2 NFHiWYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfjWHVXUUN3ME2wMlI1QDB{IN88US=> Mne1V2FPT0WU
IGROV-1 NWjDemdrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMkW5OVIh|ryP M1m1TXNCVkeHUh?=
TK10 NGnscnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwMk[3N|gh|ryP NHjpU5VUSU6JRWK=
EoL-1-cell MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLYNmFTUUN3ME2wMlI3QDl{IN88US=> NYO0dJhJW0GQR1XS
HO-1-N-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\YfGlEPTB;MD6yO|g2OyEQvF2= NXK4[mxRW0GQR1XS
BHY NVLSTpFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TqTmlEPTB;MD6yPFY2PSEQvF2= MXPTRW5ITVJ?
LU-139 NYHBSFU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlKwTWM2OD1yLkOwOVEh|ryP MkjNV2FPT0WU
23132-87 NFjJN25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnX0TWM2OD1yLkOxPVI{KM7:TR?= MVXTRW5ITVJ?
ACHN M2XMS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHLNGVKSzVyPUCuN|E6QTRizszN NHHEeZlUSU6JRWK=
DoTc2-4510 M{HoT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLjV5BwUUN3ME2wMlMzOjF7IN88US=> MkjOV2FPT0WU
BB65-RCC MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfTUWdKSzVyPUCuN|Q2QTNizszN MnXBV2FPT0WU
HLE MmrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwM{WwOFYh|ryP MmfxV2FPT0WU
HCC1419 M4TTbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPKTWM2OD1yLkO2OFA5KM7:TR?= NVTWdXc5W0GQR1XS
A388 M4nNTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwM{[4OVch|ryP M1f3WXNCVkeHUh?=
NUGC-3 NUHEbpUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrISoxKSzVyPUCuN|g{PzNizszN M1rUcHNCVkeHUh?=
KYSE-180 NYnSSoxWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDZTWM2OD1yLkO5NFg6KM7:TR?= MU\TRW5ITVJ?
TE-6 NFjDbo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnK3TWM2OD1yLkSwNlQ3KM7:TR?= MlTxV2FPT0WU
A498 NUTNN4F6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvsRXlVUUN3ME2wMlQxPjd2IN88US=> MkXpV2FPT0WU
NCI-H1648 NWnBUolOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPxZ4tkUUN3ME2wMlQ1OTh{IN88US=> MmTiV2FPT0WU
DU-145 M4DQdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HyNWlEPTB;MD60OFg{OyEQvF2= MlXlV2FPT0WU
CW-2 MkPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLYTWM2OD1yLkS2PVE1KM7:TR?= NIHEe25USU6JRWK=
A431 M1\uNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUf5eFZpUUN3ME2wMlQ5OjN|IN88US=> MXTTRW5ITVJ?
SAS NUfTS5JtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLRXIluUUN3ME2wMlQ5Ozl6IN88US=> MnnjV2FPT0WU
NCI-H2126 NGSxT4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHmOllnUUN3ME2wMlUyQTJ4IN88US=> MUPTRW5ITVJ?
NCI-H358 NWq1OWEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwNUOyNUDPxE1? MWfTRW5ITVJ?
FADU M4nwT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTITWM2OD1yLkW0OFA1KM7:TR?= M{TBS3NCVkeHUh?=
ACN NELwWGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTWTWM2OD1yLkW1NFk1KM7:TR?= MX\TRW5ITVJ?
HCC70 NXjwfIV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWT4OoRzUUN3ME2wMlU4PjZzIN88US=> NGT3NpRUSU6JRWK=
NCI-H1838 NFXCV2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvvOGdKSzVyPUCuOlAzQTlizszN NWrXPG5wW0GQR1XS
CAL-54 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwNkG2NlEh|ryP Mkj0V2FPT0WU
NCI-H1975 MoXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\kTWM2OD1yLk[xO|I5KM7:TR?= NVvLRYNXW0GQR1XS
COR-L88 M3LVeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXFTWM2OD1yLk[0NVE{KM7:TR?= M4XzUXNCVkeHUh?=
CTV-1 MkjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3KdoRKSzVyPUCuOlQ{QTJizszN NYm0dHRiW0GQR1XS
EW-18 MkP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\0S5hKSzVyPUCuOlg3QThizszN NVHGdW9QW0GQR1XS
HCC1806 NYK0WplsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTxdWg5UUN3ME2wMlY6PjZ4IN88US=> NUW3SZQyW0GQR1XS
HuP-T4 NGLKNGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwNkm3OkDPxE1? NEfFWWlUSU6JRWK=
MDA-MB-361 NWThU4w6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\UTWM2OD1yLkeyOlYzKM7:TR?= NIT4eHJUSU6JRWK=
NCI-H1573 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwN{O2N{DPxE1? NYXMVppzW0GQR1XS
KU-19-19 M3HLWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;ieWlEPTB;MD63O|Q3PCEQvF2= Mnq4V2FPT0WU
COLO-678 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLLfXNyUUN3ME2wMlgxQDN2IN88US=> NE\Ud49USU6JRWK=
C-33-A MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrrXnBKSzVyPUCuPFEzQTdizszN MYLTRW5ITVJ?
Calu-3 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;TTWM2OD1yLkixOFM1KM7:TR?= NF\UOZhUSU6JRWK=
AGS NIHjRo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1e3SGlEPTB;MD64N|Y1QCEQvF2= M4f1OnNCVkeHUh?=
SCC-25 NYOxclN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUf2R5pCUUN3ME2wMlg1OTdzIN88US=> M17Jc3NCVkeHUh?=
JVM-2 NIjpdoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPpcmo6UUN3ME2wMlg5Ojl7IN88US=> M2HxXHNCVkeHUh?=
HCE-T MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;l[mlEPTB;MD64PFQzQCEQvF2= Mn7FV2FPT0WU
ES4 M33Pbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXZfFVGUUN3ME2wMlk4QDN4IN88US=> NEGyUpVUSU6JRWK=
EKVX MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXLXYtKSzVyPUGuNFExPjRizszN NYroSJlzW0GQR1XS
D-542MG NFjHcndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{n5WmlEPTB;MT6wNVA3PCEQvF2= NIj1bYVUSU6JRWK=
SW1116 M37DfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfCNYpLUUN3ME2xMlAyOjh5IN88US=> NEj2fJFUSU6JRWK=
5637 NH3mTYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDoWmZqUUN3ME2xMlAyPTFizszN MWXTRW5ITVJ?
HT-1376 NWLyUFlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjFNFVzUUN3ME2xMlAyPTF|IN88US=> M4q2cXNCVkeHUh?=
NB69 MlTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4SzT2lEPTB;MT6wNlk1PSEQvF2= M1;IcXNCVkeHUh?=
YKG-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPrVJhzUUN3ME2xMlA2PDF7IN88US=> MXvTRW5ITVJ?
EW-3 MoSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnob2VKSzVyPUGuNFc5QDNizszN MWHTRW5ITVJ?
GCIY MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTFwMEixNFQh|ryP MlKyV2FPT0WU
SK-MES-1 NWSxeXJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTFwMUG0PFch|ryP NXrkd2FnW0GQR1XS
PANC-08-13 NGP2Xo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DDTGlEPTB;MT6xOlQyPiEQvF2= NXnTO3JnW0GQR1XS
SK-NEP-1 MmfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\mZplKSzVyPUGuNVc2OTNizszN NHz0OppUSU6JRWK=
SW954 NVW2VYsyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkOyTWM2OD1zLkKwNlE1KM7:TR?= NHrGVIJUSU6JRWK=
NCI-SNU-5 NWLXT5hYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XUTWlEPTB;MT6yN|kh|ryP MX3TRW5ITVJ?
SW48 NXn0e5UzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTpPW1KSzVyPUGuNlU1OzJizszN MX;TRW5ITVJ?
HT-3 NXzteFZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrOSlNKSzVyPUGuNlg4PTNizszN NVjvTmhCW0GQR1XS
ETK-1 M{LVVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTFwM{e0OVYh|ryP MXPTRW5ITVJ?
SCC-15 NYrBe3gzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTRUFhTUUN3ME2xMlM6PDVzIN88US=> MmfPV2FPT0WU
DU-4475 Ml2xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{frZWlEPTB;MT60NFEzOSEQvF2= Mk\wV2FPT0WU
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NCI-H727 M4n5S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRThwMUC0NkDPxE1? NUPs[2lbW0GQR1XS
SW1710 MlOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE[2XYZKSzVyPUiuNVg2OTVizszN M4fy[XNCVkeHUh?=
D-502MG MmXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4L2WGlEPTB;OD6yPVI5OiEQvF2= MWDTRW5ITVJ?
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HAL-01 NFTDcYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXWO|IxUUN3ME24MlUyQTFizszN NFi2eHBUSU6JRWK=
GT3TKB M4Lsemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRThwNke5OlQh|ryP NWjlZ25sW0GQR1XS
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EW-11 MmHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTCO2pIUUN3ME25MlE4PjV|IN88US=> NYfRfVNuW0GQR1XS
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C32 NEOxNIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTlwM{OwOlQh|ryP NIXubZpUSU6JRWK=
NCI-H1703 NWruWlJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3P3N2lEPTB;OT6zOFM4PSEQvF2= MmXqV2FPT0WU
NCI-H1650 NX:zbGN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXSRpJ[UUN3ME25MlYxQTR4IN88US=> MXPTRW5ITVJ?
NCI-H1563 M1rubWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITFb3VKSzVyPUmuO|YxOzFizszN MnvmV2FPT0WU
CAL-85-1 NVTNeXZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTlwOEezPFMh|ryP MY\TRW5ITVJ?
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MHH-PREB-1 M2rHRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7GTWM2OD1zMD6xPVk6KM7:TR?= NHTUbHBUSU6JRWK=
DEL NVK5V5lCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUf5O2F5UUN3ME2xNE4{QTR4IN88US=> NF7jOYhUSU6JRWK=
HuCCT1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYT6XYhTUUN3ME2xNE43ODN|IN88US=> M2LpcnNCVkeHUh?=
OVCAR-4 M1zvS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PQXWlEPTB;MUCuPFg{PSEQvF2= NE\4[JhUSU6JRWK=
CAL-72 NF3YcmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfOb2RKSzVyPUGwMlk{QTFizszN NFj4dnFUSU6JRWK=
HCC1954 NWfoeVJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIG2WpJKSzVyPUGxMlA4PTRizszN NVLFVHFQW0GQR1XS
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UACC-62 NXXzOlhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTFzLkKzOlgh|ryP MofuV2FPT0WU
NCI-H650 Mmq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTFzLkK0NVgh|ryP M2OyTXNCVkeHUh?=
ALL-PO NF;LeVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3n0O2lEPTB;MUGuNlUyOiEQvF2= MUHTRW5ITVJ?
T84 NHLYPXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\qXGZsUUN3ME2xNU4{QTB5IN88US=> MkHEV2FPT0WU
IST-MEL1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXQTWM2OD1zMT60OVU6KM7:TR?= M{O0UHNCVkeHUh?=
SW626 NV3iT5BkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHYWI9LUUN3ME2xNU42PzV3IN88US=> NIPMOIRUSU6JRWK=
RPMI-2650 NELTZlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17QfmlEPTB;MUGuOVg5PSEQvF2= NGr5b2dUSU6JRWK=
MC-IXC NVH2cIxvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTFzLk[3Nlgh|ryP NFfEcHJUSU6JRWK=
HOP-62 MmPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXKclV[UUN3ME2xNU43PzZ2IN88US=> MU\TRW5ITVJ?
NOS-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYn5Umo4UUN3ME2xNU44OTB7IN88US=> NEXrT5dUSU6JRWK=
SW1573 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\xVVFPUUN3ME2xNU44Ojl3IN88US=> M3zlRXNCVkeHUh?=
WM-115 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXpTWM2OD1zMT63OVg5KM7:TR?= Mlj2V2FPT0WU
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YAPC MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTFzLkmyOVkh|ryP MoXUV2FPT0WU
MDA-MB-453 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXwTWM2OD1zMT65OVE2KM7:TR?= NGHCbotUSU6JRWK=
NCI-H596 NUe0UHdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHEcYRKSzVyPUGyMlA{PjlizszN NWXu[pRIW0GQR1XS
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RS4-11 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\GdpdxUUN3ME2xNk4yPzJ3IN88US=> NHLUe|hUSU6JRWK=
HCC1937 NVftRW5oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nad2lEPTB;MUKuO|U3PCEQvF2= MmjFV2FPT0WU
SW837 Mkf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzXb3lKSzVyPUGyMlkxOjhizszN M4XLSnNCVkeHUh?=
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PFSK-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTPfnZiUUN3ME2xN{4xPiEQvF2= M37ZSHNCVkeHUh?=
DBTRG-05MG M2XkPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWf4PW41UUN3ME2xN{4xPjN{IN88US=> M1PaSHNCVkeHUh?=
SK-UT-1 NHHtemNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4n1UGlEPTB;MUOuNVA5OyEQvF2= M3K1cHNCVkeHUh?=
OVCAR-5 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\qWIJKSzVyPUGzMlE2QTNizszN NYD3VFdjW0GQR1XS
8505C M33XR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPJd|NkUUN3ME2xN{4zODZ5IN88US=> M3H3UXNCVkeHUh?=
SK-MEL-1 NH\BOZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTF|LkexN|Uh|ryP MmHsV2FPT0WU
LK-2 MoHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE[zU5BKSzVyPUGzMlc3OzlizszN MWDTRW5ITVJ?
OE33 NHfGXJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HNVGlEPTB;MUOuO|g3KM7:TR?= M1KwVXNCVkeHUh?=
Ramos-2G6-4C10 MnjZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3Xp[2lEPTB;MUSuNFIxOiEQvF2= NIXtT3JUSU6JRWK=
EW-13 M3vKW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jEV2lEPTB;MUSuNFM2OiEQvF2= MULTRW5ITVJ?
NCI-H1793 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHz3VW1KSzVyPUG0MlIxQDdizszN MkjyV2FPT0WU
BHT-101 NGH4Z29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfufXNKSzVyPUG0MlI1OSEQvF2= NIT1XHRUSU6JRWK=
RKO MnfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HJUWlEPTB;MUSuOVA4PSEQvF2= NF7qRVhUSU6JRWK=
NEC8 NF\OeJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjwW21rUUN3ME2xOE42PDd{IN88US=> NUDLb3oxW0GQR1XS
PANC-10-05 MkO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXv6cGVkUUN3ME2xOE43OjR5IN88US=> NWjwW2dtW0GQR1XS
NCI-H2030 M2jTcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTF2Lk[0OFgh|ryP Mnq4V2FPT0WU
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HCC1395 NVP2cYdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHCPYR6UUN3ME2xOE46OzN6IN88US=> M2qyRXNCVkeHUh?=
A2058 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3YTWM2OD1zNT6wOFA6KM7:TR?= NGPCV4tUSU6JRWK=
SW1463 NUm3Xlg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPNUGdIUUN3ME2xOU4xPDh3IN88US=> M{HG[nNCVkeHUh?=
J82 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4i4XWlEPTB;MUWuNFU4KM7:TR?= Mlm5V2FPT0WU
CAL-120 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHVO4VuUUN3ME2xOU4yPDR5IN88US=> MnzyV2FPT0WU
COLO-824 MortS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTF3LkG1O|kh|ryP NVK3ToU1W0GQR1XS
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OVCAR-8 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PpN2lEPTB;MUWuPFg3OSEQvF2= NIHjcYdUSU6JRWK=
MFE-280 NWWyWpUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPHXJpzUUN3ME2xOk4xPDh6IN88US=> M4HTWXNCVkeHUh?=
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NCI-H1092 M3fBT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3e5cWlEPTB;MU[uPFMyPiEQvF2= M4eyUHNCVkeHUh?=
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NCI-H661 M1P3V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TWcmlEPTB;MU[uPVY6PCEQvF2= MlfYV2FPT0WU
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NCI-H2405 NET1PXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXYTWM2OD1zNz6xPVc1KM7:TR?= NWrQc3FNW0GQR1XS
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NCI-H2342 M2q1S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTF5LkW1O{DPxE1? NWDnN2tEW0GQR1XS
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RH-18 MmDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknXTWM2OD1zOD6wNFM2KM7:TR?= NVnsXnBVW0GQR1XS
D-283MED M13XOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTF6LkCwPFgh|ryP NEXQWZRUSU6JRWK=
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NCI-H1437 MonpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7QUmJKSzVyPUG4MlE3PDFizszN MUHTRW5ITVJ?
SW982 M2j3b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTF6LkK2O|Eh|ryP M370SnNCVkeHUh?=
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A704 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVP3SlhFUUN3ME2xPE41PzV|IN88US=> M1zSSXNCVkeHUh?=
ESS-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rqRmlEPTB;MUiuOVIxPSEQvF2= MoDsV2FPT0WU
SCH NXL5RoozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfBUndvUUN3ME2xPE43PDV4IN88US=> NV\ISGRXW0GQR1XS
COLO-320-HSR NXHzdG5RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrTUVVyUUN3ME2xPE44PDZizszN NGmzTWpUSU6JRWK=
Mo-T NGm2PFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHrTWM2OD1zOD64NlA1KM7:TR?= M1\6[3NCVkeHUh?=
Saos-2 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTF7LkGxOlIh|ryP NGPSb2NUSU6JRWK=
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KM-H2 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPM[YlKSzVyPUO0MlE4PzlizszN NYHEOlJ4W0GQR1XS
NCI-H2122 MnzkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTN2LkO0O|Eh|ryP MY\TRW5ITVJ?
ABC-1 NGq4dohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInIUXNKSzVyPUO0MlM3QTNizszN MYnTRW5ITVJ?
NCI-H1355 MkHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTrNGhKSzVyPUO0MlM5QDlizszN MYnTRW5ITVJ?
NOMO-1 M37LNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFP1OZRKSzVyPUO0MlU4ODNizszN M322cXNCVkeHUh?=
MZ7-mel MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3flU2lEPTB;M{SuOlQ5PyEQvF2= NYfDWGpsW0GQR1XS
NCI-H810 NV73eohDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTN2LkeyO|gh|ryP MnvPV2FPT0WU
D-392MG NID2b4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PVeWlEPTB;M{WuNFU3PSEQvF2= Moe5V2FPT0WU
LB771-HNC MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF25b45KSzVyPUO1MlE3PThizszN NHj4RmNUSU6JRWK=
COLO-679 M1n3[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\pXI9KSzVyPUO1MlM5QCEQvF2= M1KwXnNCVkeHUh?=
SK-PN-DW MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTN3LkSzOlkh|ryP NG\kZoJUSU6JRWK=
VA-ES-BJ NITyUlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjWTWM2OD1|NT60OlQ6KM7:TR?= M{XEZ3NCVkeHUh?=
KNS-42 MlvSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1W4fGlEPTB;M{WuOVgzPiEQvF2= NXTQOnNoW0GQR1XS
RVH-421 NYm1N|A3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2faVGlEPTB;M{WuO|Y1PSEQvF2= MoTwV2FPT0WU
P30-OHK NWHFWY5QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mle2TWM2OD1|NT64O|UzKM7:TR?= Mon2V2FPT0WU
G-402 NW\1O3pZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jPeGlEPTB;M{WuPVg3PyEQvF2= MYLTRW5ITVJ?
S-117 M1\DVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI[3WJpKSzVyPUO2MlMxODhizszN MkTwV2FPT0WU
RXF393 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELwXoJKSzVyPUO2MlM4QDVizszN MYTTRW5ITVJ?
LCLC-103H Mlq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnNTWM2OD1|Nj63PFA{KM7:TR?= NVjCfFBtW0GQR1XS
U-118-MG NGr5fGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DJV2lEPTB;M{[uPFg1PyEQvF2= MlLaV2FPT0WU
8-MG-BA NV3Jb3FvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvaTWM2OD1|Nj65OFg{KM7:TR?= MVPTRW5ITVJ?
MFH-ino MnrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLJTWM2OD1|Nz6zN|cyKM7:TR?= NED2TWJUSU6JRWK=
NCI-H23 MoO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnmWHVKUUN3ME2zO{41OTl4IN88US=> MWLTRW5ITVJ?
NCI-H446 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnWyTWM2OD1|Nz60PFYzKM7:TR?= NVf0VW13W0GQR1XS
LU-99A M3;mR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrtclVKSzVyPUO3MlU4OzFizszN M4TufXNCVkeHUh?=
KP-N-YN MnfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rU[WlEPTB;M{euOlE6PSEQvF2= M{G4NnNCVkeHUh?=
SCC-9 NXz5cFd[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTN5Lke4N|gh|ryP MX;TRW5ITVJ?
EFM-19 NUjWXYZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nFT2lEPTB;M{euO|k3PyEQvF2= M1nnZnNCVkeHUh?=
A427 NUDTd5ZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\ufm5vUUN3ME2zO{46OTB5IN88US=> NFLJdldUSU6JRWK=
LB831-BLC Mlj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHwUmJKSzVyPUO4MlYxOzlizszN Mm\lV2FPT0WU
HOS MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEG1c5ZKSzVyPUO5MlYzPzNizszN MUXTRW5ITVJ?
LAN-6 NVK3PYlqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUL0U5pNUUN3ME20NE4xOTF{IN88US=> NIPmT25USU6JRWK=
U251 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTRyLkSwOVQh|ryP MWTTRW5ITVJ?
SNU-387 NFvTfGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmj1TWM2OD12MD60OVU{KM7:TR?= M2DmSHNCVkeHUh?=
DMS-79 NGrjNWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XSXmlEPTB;NECuOVg5QSEQvF2= M1q2SXNCVkeHUh?=
SK-LU-1 NWHIUVRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTRyLk[1Olgh|ryP NXL2TVZ4W0GQR1XS
HT NH7FOWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37iSWlEPTB;NECuOlY{QSEQvF2= MYTTRW5ITVJ?
KP-N-YS M4KwU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLLeVJKSzVyPUSwMlY4PjhizszN NVP0XHk6W0GQR1XS
DMS-114 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHEUFBiUUN3ME20NE45Ozd2IN88US=> Mn7WV2FPT0WU
HUTU-80 MkjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\Nb41qUUN3ME20NU4xPTZ7IN88US=> M1fhcHNCVkeHUh?=
ONS-76 NXzVNFJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPKPXlTUUN3ME20NU41PzB7IN88US=> NX3EZXNNW0GQR1XS
A673 M1X2RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\5TWM2OD12MT61NVU4KM7:TR?= NEjZNFlUSU6JRWK=
HPAF-II M4\4Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPoTWM2OD12MT62O|A6KM7:TR?= NIrmZ5ZUSU6JRWK=
UACC-257 M4Xh[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LoUWlEPTB;NEGuO|M3QSEQvF2= M1fPS3NCVkeHUh?=
EW-22 M2TYeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3JVVNlUUN3ME20NU45Pjl5IN88US=> NH7XNpNUSU6JRWK=
NCI-H1755 M3HwOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTRzLki3NlUh|ryP MYHTRW5ITVJ?
KYSE-150 NYXzTYRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH23dJNKSzVyPUSyMlE4QDJizszN MmXZV2FPT0WU
CGTH-W-1 M3TBO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPTSWZ[UUN3ME20Nk41QTV3IN88US=> NIS4N|FUSU6JRWK=
NB13 Mln5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;1TWM2OD12Mj62NlE4KM7:TR?= M1PhUHNCVkeHUh?=
SW872 MonnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTR{Lk[zN|Eh|ryP NXK0SIpNW0GQR1XS
KP-4 NYLzTYpOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PFVmlEPTB;NEKuPFg{OiEQvF2= NVvoTlE3W0GQR1XS
HCC38 NVLRV4szT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnj0TWM2OD12Mj65OlE5KM7:TR?= M1nuSnNCVkeHUh?=
BB49-HNC MlTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\kZXlKSzVyPUSzMlI{PTZizszN M{TEPXNCVkeHUh?=
CAL-62 M{LnU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jLfWlEPTB;NEOuOFAzQCEQvF2= NETxeGtUSU6JRWK=
NCI-H2029 M1faRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1j1O2lEPTB;NEOuOVU5OSEQvF2= NUn4[2Y3W0GQR1XS
M14 M4T5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUK0Snd1UUN3ME20OE4yOzN{IN88US=> MXXTRW5ITVJ?
COLO-680N NVz1Z|BUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPVeplKSzVyPUS0MlM{QSEQvF2= NFvpUGJUSU6JRWK=
Hs-578-T MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7TW4lUUUN3ME20OU4xOjl2IN88US=> M3TnTXNCVkeHUh?=
MSTO-211H NEHvVpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XKSGlEPTB;NEWuPVQ5OiEQvF2= NH:zbnVUSU6JRWK=
EW-1 Mn;BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLwToJwUUN3ME20OU46Pjh7IN88US=> M2LEe3NCVkeHUh?=
SW948 M{XZOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvlTWM2OD12Nj60OFYzKM7:TR?= M3f3WHNCVkeHUh?=
NCI-H460 Mm\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTR4LkWyN{DPxE1? NV\zOoZwW0GQR1XS
CAS-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUm5VWl3UUN3ME20Ok44PzBzIN88US=> NWCzR5c1W0GQR1XS
TGBC11TKB NGTseZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV65OZJNUUN3ME20O{4yPzd5IN88US=> MofFV2FPT0WU
HD-MY-Z MlzOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\oPGFKSzVyPUS4Mlc5PiEQvF2= Mn\mV2FPT0WU
NCI-H226 NXTOR|JbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHSy[WhKSzVyPUS5Mlc4QDVizszN NHHYbm5USU6JRWK=
PA-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\5dGVKSzVyPUS5Mlg{OzVizszN NHzkPZRUSU6JRWK=
LB2518-MEL MkS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDpTWM2OD12OT64O|I{KM7:TR?= NFHqNmpUSU6JRWK=
A101D MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTR7Lkm0NlUh|ryP NVj1O2o6W0GQR1XS
NCI-H2087 NF;rZY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTR7Lkm2PFIh|ryP NXjQU5E3W0GQR1XS

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

アッセイ
Methods Test Index PMID
Western blot
CIP2A / p-AKT / AKT / PARP; 

PubMed: 25537503     


Time-dependent effects of afatinib on CIP2A, p-AKT and apoptosis-related proteins in the sensitive H358 and resistant H460 cells. Cells were exposed to 10 μM afatinib for up to 48 hours. Immunoblots were scanned and quantitated to determine the ratio of the level of CIP2A to actin. Data are mean ± SD. n = 3 for the different time intervals.

p-EGFR / p-IGF1R / p-ERK / p-AKT; 

PubMed: 26052929     


Effects of afatinib on EGFR and IGF1R Signaling Pathways. H1975 cells were treated with afatinib with various doses and cell lysates were subjected to Western blot analysis. Afatinib effectively inhibits p-EGFR and p-ERK while p-AKT was partially inhibited. IGF1R phosphorylation was increased upon afatinib treatment in H1975 cells.

p-VEGFR2 / VEGFR2 / JAG1 / DLL4 / NICD1 ; 

PubMed: 28533486     


HUVECs were cultured in the presence of Vatalanib (100 nM) or DBZ (10 nM) for 1 h and then treated for 15 min with rhgal-3 (37 nM) and cultured for additional 6 hrs. After this period, the total protein was isolated and the protein levels of galectin-3, NICD1, DLL4, JAG1, VEGFR2 and VEGFR2-p were assessed by Western blot. β-actin was used as a loading control.

25537503 26052929 28533486
Growth inhibition assay
Cell apoptosis; 

PubMed: 25537503     


Dose-dependent effects of afatinib on apoptosis. Data are mean ± SD. n = 3 for each concentration. *, p < 0.05, **, p < 0.01, vs. no afatinib. 

Cell viability; 

PubMed: 26515464     


A. MTS assay for Ba/F3 cells harboring EGFR exon 19 deletion and L858R. The proportional cell viability is shown. B. MTS assay for Ba/F3 cells harboring EGFR exon 19 deletion+T790M and L858R+T790M. The proportional cell viability is shown. C. MTS assay for Ba/F3 cells harboring wild type EGFR. The proportional cell viability is shown. Erlotinib, afatinib, osimertinib, and rociletinib were used as EGFR-TKIs. Error bars indicate standard deviation.

25537503 26515464
Immunofluorescence
p65; 

PubMed: 26317651     


Effects of different treatments on the nuclear translocation of the NF-κB subunit p65. A2780T cells were treated with 2.5 μM afatinib for 48 hours, or 10 μM PDTC for 2 hours. Subsequently, the NF-κB subunit p65 (red) was localized by immunofluorescence and a confocal microscopy. Nuclei were stained with DAPI (blue). Scale bar = 10 μM.

vacuoles; 

PubMed: 29713246     


Autophagy activation upon treatment with Afatinib and Sorafenib was validated using immunofluorescence in order to visualize a creation of autophagosomes; ×60 magnification. DMSO treatment was used as control. Green—autophagy vacuoles; Blue—Hoechst, nuclear staining. 

26317651 29713246
体内試験 Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]

お薦めの試験操作(参考用のみ)

キナーゼ試験:

[1]

- 合併

In vitro kinase activity assays:

The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.
細胞試験:

[1]

- 合併
  • 細胞株: NSCLC cells
  • 濃度: 0-10 μM
  • 反応時間: 1 hour
  • 実験の流れ:

    1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.


    (参考用のみ)
動物試験:

[1]

- 合併
  • 動物モデル: Athymic NMRI-nu/nu female mice
  • 投薬量: 20 mg/kg
  • 投与方法: Oral administration
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 97 mg/mL (199.61 mM)
Water Insoluble
Ethanol ''15 mg/mL ''15
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
混合させたのち直ちに使用することを推奨します。
10mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 485.94
化学式

C24H25ClFN5O3

CAS No. 850140-72-6
Storage powder
in solvent
別名 N/A
Smiles CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4

投与溶媒組成計算器(クリア溶液)

ステップ1:実験データを入力してください。(実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します)
投与量 mg/kg 動物平均体重 g 投与体積(動物毎) ul 動物数
ステップ2:投与溶媒の組成を入力してください。(ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください)
% DMSO % % Tween 80 % ddH2O
計算リセット

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (mg) = 濃度 (mM) x 体積 (mL) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04497584 Not yet recruiting Drug: Afatinib + Prednisone Advanced Squamous Non Small Cell Lung Cancer University of Texas Southwestern Medical Center September 1 2020 Phase 2
NCT04413201 Not yet recruiting Drug: Afatinib|Drug: Osimertinib Non-squamous NSCLC Michael Hopp|Boehringer Ingelheim|Johannes Gutenberg University Mainz June 30 2020 Phase 4
NCT04206787 Recruiting Drug: Afatinib Non-squamous Non-Small Cell Lung Cancer Boehringer Ingelheim May 20 2020 --
NCT04158947 Recruiting Drug: Afatinib|Drug: T-DM1 HER2-positive Breast Cancer|Brain Metastases xuexin he|Second Affiliated Hospital School of Medicine Zhejiang University May 10 2020 Phase 2
NCT03711422 Not yet recruiting Drug: Afatinib Non-small Cell Lung Cancer|Leptomeningeal Disease|Central Nervous System Metastases National Cancer Centre Singapore October 2018 Phase 1
NCT03083678 Recruiting Drug: Afatinib Chordoma Leiden University Medical Center|Chordoma Foundation|Boehringer Ingelheim June 21 2018 Phase 2

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答:

    For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

EGFRシグナル伝達経路

EGFR Inhibitors with Unique Features

相関EGFR製品

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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID