Afatinib (BIBW2992)

製品コードS1011

Afatinib (BIBW2992)化学構造

分子量(MW):485.94

Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.

サイズ 価格(税別)  
JPY 39840.00
JPY 19920.00
JPY 34860.00
JPY 94620.00

文献中Selleckの製品使用例(37)

カスタマーフィードバック(4)

  • Cytoxicity of irreversible EGFR TKIS and ethacrynic acid on breast cells lines. A, Mean IC50 value of Afatinib.

    Oncotarget, 2016, 7(36):58038-58050. Afatinib (BIBW2992) purchased from Selleck.

    Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

  • Inhibition of anchorage-independent growth of lung tumor cell lines by selected inhibitors. Each selected cell line was treated with the indicated inhibitor at 0.1 μM and 1 μM concentrations for two weeks and cell colony size formation was scored under the Nikon inverted-phase microscope.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

    After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of BIBW2992 for 3h,followed by 15-minute stimolation of 100ng/ml EGF

    Dr. Zhang of Tianjin Medical University. Afatinib (BIBW2992) purchased from Selleck.

製品安全説明書

EGFR阻害剤の選択性比較

生物活性

製品説明 Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.
ターゲット
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
ErbB4 [2]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 1 nM 10 nM 14 nM
体外試験

BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\Ne2lEPTB;MD6wNFU4OiEQvF2= MU\TRW5ITVJ?
KASUMI-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nyPGlEPTB;MD6wNFkyOSEQvF2= MUHTRW5ITVJ?
HCC2218 NFjFZXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwMEC5PFch|ryP MkO1V2FPT0WU
KARPAS-45 NWfSc3p2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\tOmlEPTB;MD6wNVY4OSEQvF2= MYfTRW5ITVJ?
HSC-4 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTOc4tVUUN3ME2wMlAyPzR6IN88US=> MW\TRW5ITVJ?
CHL-1 MkDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPaRohKSzVyPUCuNFE5OzlizszN MYHTRW5ITVJ?
KY821 NX3MT3pMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PlOWlEPTB;MD6wNlA3KM7:TR?= NF;1cJVUSU6JRWK=
NCI-N87 NX35dHVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwMEK3O|Mh|ryP MVrTRW5ITVJ?
DOK MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVf5VnZJUUN3ME2wMlA{OTl2IN88US=> MlzYV2FPT0WU
DSH1 NHH4WZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjyZZhKSzVyPUCuNFM{OTRizszN M4jTVHNCVkeHUh?=
MDA-MB-175-VII Mk[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonITWM2OD1yLkCzOFE3KM7:TR?= NH7hWpVUSU6JRWK=
NCI-H2170 M2XkOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwMEO3Nlgh|ryP MlT0V2FPT0WU
BT-474 M3\tTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;wS2lEPTB;MD6wOFk5PiEQvF2= NHLWXIFUSU6JRWK=
EFO-27 NHjQcmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVixWVhNUUN3ME2wMlA2OTh{IN88US=> NIq1bVVUSU6JRWK=
NCI-H720 NWPGdm9DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3IWop[UUN3ME2wMlA2OzJ3IN88US=> NVP1RWR3W0GQR1XS
PC-14 NEKzcopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nWdWlEPTB;MD6wOVY3QCEQvF2= MlXiV2FPT0WU
EC-GI-10 NU\hcHNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHL4dlVKSzVyPUCuNFU6OTJizszN MWrTRW5ITVJ?
KYSE-450 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPWOJBKSzVyPUCuNFU6PzhizszN NEDH[GNUSU6JRWK=
BPH-1 M1r6R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGP1enpKSzVyPUCuNFU6QDhizszN NIDXTlhUSU6JRWK=
NCI-H292 MmnUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwME[wPUDPxE1? NH35[WtUSU6JRWK=
H9 M1LrbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LmXGlEPTB;MD6wO|E{OiEQvF2= NHnwPIdUSU6JRWK=
NCI-H526 MmnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DI[WlEPTB;MD6wO|gzOyEQvF2= M33xTXNCVkeHUh?=
NCI-H1623 M2[yXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMEiwNlUh|ryP MVPTRW5ITVJ?
KYSE-140 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\5[2lEPTB;MD6wPFM{KM7:TR?= MWXTRW5ITVJ?
Ca9-22 M1\We2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwMEizOVMh|ryP NYWyRZhYW0GQR1XS
AU565 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTvTWM2OD1yLkC4OVA1KM7:TR?= MmPlV2FPT0WU
ZR-75-30 M1LQNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwMEm1OFUh|ryP MULTRW5ITVJ?
NCI-H1770 M4r3b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{L5d2lEPTB;MD6xNFI5KM7:TR?= MnHOV2FPT0WU
LB2241-RCC NFjRfmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\DZWlEPTB;MD6xNFg5PCEQvF2= MVfTRW5ITVJ?
CAL-39 MnO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwMUG3PVIh|ryP NXLMTWlGW0GQR1XS
UACC-893 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEmzNXhKSzVyPUCuNVE5QDVizszN M3HtbnNCVkeHUh?=
LU-65 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3MUGxKSzVyPUCuNVI3OzNizszN NWnxVo1pW0GQR1XS
HN MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\iTWM2OD1yLkGzNFc4KM7:TR?= MV\TRW5ITVJ?
TI-73 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwMUS3NVUh|ryP MXPTRW5ITVJ?
KU812 NXfKZVhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\VfmlKSzVyPUCuNVU1PTZizszN MWTTRW5ITVJ?
SW13 MoLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTje3JKSzVyPUCuNVYzOTZizszN MlriV2FPT0WU
BB30-HNC NX70TGFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXex[Yc5UUN3ME2wMlE3PTd4IN88US=> NV;kSHhSW0GQR1XS
HSC-2 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjaVXJKSzVyPUCuNVY5OzdizszN MV\TRW5ITVJ?
BV-173 NI\id4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXMeFJKSzVyPUCuNVc2QTZizszN MoXHV2FPT0WU
CAL-27 MkfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PqWWlEPTB;MD6xO|Y{PiEQvF2= MmSxV2FPT0WU
SBC-1 M4PTdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTW[YxKSzVyPUCuNVg6PTlizszN M2\jcXNCVkeHUh?=
CAL-33 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMkCxPFQh|ryP NHnUU4dUSU6JRWK=
NCI-H209 NHm2dYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILvRotKSzVyPUCuNlA1PiEQvF2= NIPxSW1USU6JRWK=
COR-L105 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPreWdjUUN3ME2wMlIyODh2IN88US=> NXvjXmcxW0GQR1XS
HSC-3 NVrFR4FjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1T3RmlEPTB;MD6yNVE6QCEQvF2= NIrUWGlUSU6JRWK=
NCI-H69 M1nr[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXi2ZVhuUUN3ME2wMlIyPDVzIN88US=> M2TqSnNCVkeHUh?=
MOLT-13 M{PBfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwMkO5O|Uh|ryP NWfOOHB{W0GQR1XS
ML-2 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTBwMkS4NFIh|ryP M2DZPHNCVkeHUh?=
IGROV-1 MlvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPoUXNKSzVyPUCuNlU6PTJizszN MYHTRW5ITVJ?
TK10 NHrlN5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13PO2lEPTB;MD6yOlc{QCEQvF2= MljiV2FPT0WU
EoL-1-cell NIDQSnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwMk[4PVIh|ryP MXnTRW5ITVJ?
HO-1-N-1 M4fWZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;ZR2lEPTB;MD6yO|g2OyEQvF2= M{H5fHNCVkeHUh?=
BHY NFj4ToZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljCTWM2OD1yLkK4OlU2KM7:TR?= MX7TRW5ITVJ?
LU-139 MlT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwM{C1NUDPxE1? MW\TRW5ITVJ?
23132-87 M4TFNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\3cFZKSzVyPUCuN|E6OjNizszN M2iwfHNCVkeHUh?=
ACHN MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHjVHJKSzVyPUCuN|E6QTRizszN NUnPcnVZW0GQR1XS
DoTc2-4510 NYC2ZZh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnqNoY5UUN3ME2wMlMzOjF7IN88US=> M4HRZXNCVkeHUh?=
BB65-RCC M1T3d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwM{S1PVMh|ryP MWTTRW5ITVJ?
HLE MnvlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDwXIZKSzVyPUCuN|UxPDZizszN MVTTRW5ITVJ?
HCC1419 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkGyTWM2OD1yLkO2OFA5KM7:TR?= MYnTRW5ITVJ?
A388 NF3hdJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojiTWM2OD1yLkO2PFU4KM7:TR?= NH;De5hUSU6JRWK=
NUGC-3 MkG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvxNoRKSzVyPUCuN|g{PzNizszN M4\uOXNCVkeHUh?=
KYSE-180 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXMTWM2OD1yLkO5NFg6KM7:TR?= NFXXU4xUSU6JRWK=
TE-6 Mn\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HEfmlEPTB;MD60NFI1PiEQvF2= NFLEU4lUSU6JRWK=
A498 M4Tmfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwNEC2O|Qh|ryP NHy0[Y5USU6JRWK=
NCI-H1648 M4[3S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HLNGlEPTB;MD60OFE5OiEQvF2= NYTNUXNOW0GQR1XS
DU-145 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfMPJE1UUN3ME2wMlQ1QDN|IN88US=> MmrtV2FPT0WU
CW-2 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUm4WoMzUUN3ME2wMlQ3QTF2IN88US=> NYnTbmRTW0GQR1XS
A431 NEjFNWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonMTWM2OD1yLkS4NlM{KM7:TR?= M2\IZnNCVkeHUh?=
SAS M136dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nCN2lEPTB;MD60PFM6QCEQvF2= M4LnfXNCVkeHUh?=
NCI-H2126 NFTU[XlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;qT4Z3UUN3ME2wMlUyQTJ4IN88US=> NEjVUndUSU6JRWK=
NCI-H358 Mli1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFWz[YxKSzVyPUCuOVMzOSEQvF2= MYnTRW5ITVJ?
FADU MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3r5S2lEPTB;MD61OFQxPCEQvF2= NV3mcmNpW0GQR1XS
ACN NW\iNW1lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzOTWM2OD1yLkW1NFk1KM7:TR?= MYPTRW5ITVJ?
HCC70 MnHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\4SWNKSzVyPUCuOVc3PjFizszN M2fzOnNCVkeHUh?=
NCI-H1838 NVzI[29IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\Hd4ZKSzVyPUCuOlAzQTlizszN MY\TRW5ITVJ?
CAL-54 Mof2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDwTWM2OD1yLk[xOlIyKM7:TR?= MVvTRW5ITVJ?
NCI-H1975 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwNkG3Nlgh|ryP Mm[2V2FPT0WU
COR-L88 Mnq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWr4PWhQUUN3ME2wMlY1OTF|IN88US=> MnrPV2FPT0WU
CTV-1 NVv5e3RXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwNkSzPVIh|ryP MlTkV2FPT0WU
EW-18 M4\vcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkGxTWM2OD1yLk[4Olk5KM7:TR?= NWO0VJQ6W0GQR1XS
HCC1806 M4PwUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwNkm2OlYh|ryP MWXTRW5ITVJ?
HuP-T4 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zGSGlEPTB;MD62PVc3KM7:TR?= NUToUWxPW0GQR1XS
MDA-MB-361 MoTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37ZZmlEPTB;MD63NlY3OiEQvF2= M2S4OnNCVkeHUh?=
NCI-H1573 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnwTWM2OD1yLkezOlMh|ryP NVjDU25LW0GQR1XS
KU-19-19 Mlm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYn0dYdQUUN3ME2wMlc4PDZ2IN88US=> M{TldnNCVkeHUh?=
COLO-678 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwOEC4N|Qh|ryP M{WySnNCVkeHUh?=
C-33-A M3rSfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\GOZNUUUN3ME2wMlgyOjl5IN88US=> NIjEflVUSU6JRWK=
Calu-3 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4m3T2lEPTB;MD64NVQ{PCEQvF2= M4DFO3NCVkeHUh?=
AGS NHP2eI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;ZbmlKSzVyPUCuPFM3PDhizszN NEnSPYFUSU6JRWK=
SCC-25 M3LTb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\FOWlEPTB;MD64OFE4OSEQvF2= NV76VIhvW0GQR1XS
JVM-2 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPUTWM2OD1yLki4Nlk6KM7:TR?= MVHTRW5ITVJ?
HCE-T MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTBwOEi0Nlgh|ryP NH\hW4JUSU6JRWK=
ES4 NYXIRnZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XoXmlEPTB;MD65O|g{PiEQvF2= NFvPZZBUSU6JRWK=
EKVX MknBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjYTWM2OD1zLkCxNFY1KM7:TR?= NIS5PYdUSU6JRWK=
D-542MG NV7WTJQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXLTWM2OD1zLkCxNFY1KM7:TR?= NFzwTYJUSU6JRWK=
SW1116 MmXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTFwMEGyPFch|ryP M1H3W3NCVkeHUh?=
5637 MoDGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkX0TWM2OD1zLkCxOVEh|ryP NVnG[4JUW0GQR1XS
HT-1376 NHHGeVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nQfWlEPTB;MT6wNVUyOyEQvF2= Ml7vV2FPT0WU
NB69 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTFwMEK5OFUh|ryP MXfTRW5ITVJ?
YKG-1 NH;iN4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLiTWM2OD1zLkC1OFE6KM7:TR?= MlPiV2FPT0WU
EW-3 MnrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYn5WHA2UUN3ME2xMlA4QDh|IN88US=> MYfTRW5ITVJ?
GCIY MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXL3Vo9jUUN3ME2xMlA5OTB2IN88US=> M1jGfHNCVkeHUh?=
SK-MES-1 NE\HNY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIj0eVZKSzVyPUGuNVE1QDdizszN M3vOSnNCVkeHUh?=
PANC-08-13 M3zkbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzpTWM2OD1zLkG2OFE3KM7:TR?= NGfPboFUSU6JRWK=
SK-NEP-1 NHHTU2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjJWWFKSzVyPUGuNVc2OTNizszN NWXTVIh4W0GQR1XS
SW954 NWTnZpVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTFwMkCyNVQh|ryP MY\TRW5ITVJ?
NCI-SNU-5 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PWfGlEPTB;MT6yN|kh|ryP NVLrSGJ6W0GQR1XS
SW48 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfkTWM2OD1zLkK1OFMzKM7:TR?= NEHWfmRUSU6JRWK=
HT-3 M17sfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDPTWM2OD1zLkK4O|U{KM7:TR?= M4LjOnNCVkeHUh?=
ETK-1 Mk\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XpSWlEPTB;MT6zO|Q2PiEQvF2= M4i4OHNCVkeHUh?=
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KURAMOCHI Mof4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTdwOUS4NVEh|ryP MUDTRW5ITVJ?
BE-13 Ml3RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PlWWlEPTB;Nz65PFEyOiEQvF2= MV7TRW5ITVJ?
VMRC-RCZ NXH1dpFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;5TWM2OD16LkCxOlk4KM7:TR?= NEnr[pNUSU6JRWK=
NCI-H727 MlXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHG2SlFKSzVyPUiuNVA1OiEQvF2= M{e4b3NCVkeHUh?=
SW1710 NGDlN3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfETWM2OD16LkG4OVE2KM7:TR?= NFPLcVhUSU6JRWK=
D-502MG NWCyfHM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPSTWM2OD16LkK5NlgzKM7:TR?= M4TGWnNCVkeHUh?=
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HAL-01 NInPSFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRThwNUG5NUDPxE1? M4rFUXNCVkeHUh?=
GT3TKB NUXydmJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRThwNke5OlQh|ryP MWPTRW5ITVJ?
SK-OV-3 NH;GN|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXqzN49xUUN3ME24MlcyOzJ7IN88US=> NF;R[4JUSU6JRWK=
COLO-829 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLIO5FvUUN3ME24MlgxQTd4IN88US=> M1nFeXNCVkeHUh?=
OCI-AML2 NIGyWIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3Plc2lEPTB;OD65OVQ5OSEQvF2= MVPTRW5ITVJ?
OS-RC-2 M{nofWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPMO4ZKSzVyPUmuNFIyQSEQvF2= M4XsWnNCVkeHUh?=
BFTC-909 NV7jbJFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVm4VYtXUUN3ME25MlA3Pzl7IN88US=> M{nldHNCVkeHUh?=
EW-11 NYHBOXZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELBZ3JKSzVyPUmuNVc3PTNizszN MX7TRW5ITVJ?
HCE-4 MoTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLRTWM2OD17LkKxOVU5KM7:TR?= MlXEV2FPT0WU
BALL-1 MnTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTlwMkG5NFch|ryP NVHONoRLW0GQR1XS
SF539 MmDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYr6WlU6UUN3ME25MlI{PTZ{IN88US=> NEflcW1USU6JRWK=
CAMA-1 MkTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTlwMkixNlgh|ryP NY\4enJ7W0GQR1XS
C32 NGjueYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfVTWM2OD17LkOzNFY1KM7:TR?= M4W1UHNCVkeHUh?=
NCI-H1703 NF7PTmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{S0dGlEPTB;OT6zOFM4PSEQvF2= NIrSOGVUSU6JRWK=
NCI-H1650 NGe2TXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTlwNkC5OFYh|ryP NGDhdG1USU6JRWK=
NCI-H1563 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfDTWM2OD17Lke2NFMyKM7:TR?= MmD2V2FPT0WU
CAL-85-1 MnjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYSxb2E2UUN3ME25Mlg4Ozh|IN88US=> MUHTRW5ITVJ?
UM-UC-3 M2DKeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGP4O5JKSzVyPUmuPVUxOyEQvF2= NX3Oe3ZHW0GQR1XS
BxPC-3 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnJ[IZ6UUN3ME2xNE4xQTd{IN88US=> NVLNSXBlW0GQR1XS
MHH-PREB-1 M2KzOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonrTWM2OD1zMD6xPVk6KM7:TR?= NFr3WZZUSU6JRWK=
DEL NWTDZ|QzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfsTWM2OD1zMD6zPVQ3KM7:TR?= MorDV2FPT0WU
HuCCT1 NI\qWXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDJTWM2OD1zMD62NFM{KM7:TR?= M2fUUHNCVkeHUh?=
OVCAR-4 NEWxSpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfWTWM2OD1zMD64PFM2KM7:TR?= NEj2SZdUSU6JRWK=
CAL-72 NGDSZmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PtdGlEPTB;MUCuPVM6OSEQvF2= NF7zb|dUSU6JRWK=
HCC1954 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXV[48zUUN3ME2xNU4xPzV2IN88US=> M4XH[XNCVkeHUh?=
EFO-21 M33rdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzaWnFlUUN3ME2xNU4yODR3IN88US=> M2jKTXNCVkeHUh?=
FTC-133 NUezUmY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4C4XmlEPTB;MUGuNVQxPyEQvF2= NVXzV5BtW0GQR1XS
SK-MEL-24 NV\JNpVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYL5TFJXUUN3ME2xNU4zOzZ4IN88US=> NIjTO4dUSU6JRWK=
UACC-62 NXj4ZmFHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDzRnNKSzVyPUGxMlI{PjhizszN MXLTRW5ITVJ?
NCI-H650 NV\NbWdwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\jXWlEPTB;MUGuNlQyQCEQvF2= MX\TRW5ITVJ?
ALL-PO Mn7xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDa[FFKSzVyPUGxMlI2OTJizszN M1LGRnNCVkeHUh?=
T84 NEXnUoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvrOlhRUUN3ME2xNU4{QTB5IN88US=> M1O1NXNCVkeHUh?=
IST-MEL1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnVfmhKSzVyPUGxMlQ2PTlizszN NVjP[YVpW0GQR1XS
SW626 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nWVWlEPTB;MUGuOVc2PSEQvF2= M1vVe3NCVkeHUh?=
RPMI-2650 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTFzLkW4PFUh|ryP NVjpZ49mW0GQR1XS
MC-IXC NIGwT3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXifYxYUUN3ME2xNU43PzJ6IN88US=> NYrnendjW0GQR1XS
HOP-62 NV\aOXp6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPGTWM2OD1zMT62O|Y1KM7:TR?= NGTGW5hUSU6JRWK=
NOS-1 MnrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnydlZPUUN3ME2xNU44OTB7IN88US=> NFz1fWhUSU6JRWK=
SW1573 M1T6ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTFzLkeyPVUh|ryP MlzzV2FPT0WU
WM-115 NVeyUm8{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4ThdWlEPTB;MUGuO|U5QCEQvF2= MmLiV2FPT0WU
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YAPC NXnDWIpZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{j6cGlEPTB;MUGuPVI2QSEQvF2= NXXnT4pWW0GQR1XS
MDA-MB-453 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrXcIVYUUN3ME2xNU46PTF3IN88US=> MlG0V2FPT0WU
NCI-H596 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojxTWM2OD1zMj6wN|Y6KM7:TR?= NGTVNmhUSU6JRWK=
A172 NHTOWoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fkRWlEPTB;MUKuNFc6QCEQvF2= MUXTRW5ITVJ?
RS4-11 NFXjdodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\KS|VKSzVyPUGyMlE4OjVizszN NVXSOoF4W0GQR1XS
HCC1937 NEPWVoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIruWGxKSzVyPUGyMlc2PjRizszN M{XQW3NCVkeHUh?=
SW837 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnkTWM2OD1zMj65NFI5KM7:TR?= NWPzNoNRW0GQR1XS
NMC-G1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4T0SmlEPTB;MUKuPVI{PCEQvF2= MmLTV2FPT0WU
PFSK-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\XN3g5UUN3ME2xN{4xPiEQvF2= M2jnPXNCVkeHUh?=
DBTRG-05MG NWCwNoZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTqVHNxUUN3ME2xN{4xPjN{IN88US=> MVHTRW5ITVJ?
SK-UT-1 MkHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnqyTWM2OD1zMz6xNFg{KM7:TR?= M4DGUXNCVkeHUh?=
OVCAR-5 NVjhVoJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm[xTWM2OD1zMz6xOVk{KM7:TR?= NVrPeFBOW0GQR1XS
8505C NI[1fnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHH2U|ZKSzVyPUGzMlIxPjdizszN NVXlVmZjW0GQR1XS
SK-MEL-1 M3nEXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTNTWM2OD1zMz63NVM2KM7:TR?= NEnReYtUSU6JRWK=
LK-2 NGnRWohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHqXYo{UUN3ME2xN{44PjN7IN88US=> MojxV2FPT0WU
OE33 NUGwPVExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDTTWM2OD1zMz63PFYh|ryP MX\TRW5ITVJ?
Ramos-2G6-4C10 NIDWVJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfaTWM2OD1zND6wNlAzKM7:TR?= MWfTRW5ITVJ?
EW-13 Mo\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTF2LkCzOVIh|ryP NFrFXnhUSU6JRWK=
NCI-H1793 MmLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTF2LkKwPFch|ryP MXTTRW5ITVJ?
BHT-101 NH:0UWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrZN|lDUUN3ME2xOE4zPDFizszN NYnYNI1NW0GQR1XS
RKO NF;t[3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPZcnZ3UUN3ME2xOE42ODd3IN88US=> MlHUV2FPT0WU
NEC8 NIPpXpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\0OmlEPTB;MUSuOVQ4OiEQvF2= MWnTRW5ITVJ?
PANC-10-05 NInjUJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HEOWlEPTB;MUSuOlI1PyEQvF2= NWXOd4g4W0GQR1XS
NCI-H2030 NIrafYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTF2Lk[0OFgh|ryP M2Ha[nNCVkeHUh?=
C2BBe1 NEGwT2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\sTWM2OD1zND63OlQh|ryP NW\F[|dlW0GQR1XS
EM-2 Mm\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLoVGs1UUN3ME2xOE45PTd4IN88US=> M3TUc3NCVkeHUh?=
HCC1395 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7XTWM2OD1zND65N|M5KM7:TR?= M4HPZnNCVkeHUh?=
A2058 Mmm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\KcmlIUUN3ME2xOU4xPDB7IN88US=> NI\WW2NUSU6JRWK=
SW1463 NWDxWVRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXISIdKSzVyPUG1MlA1QDVizszN NGK2PZhUSU6JRWK=
J82 M{TxO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmH5TWM2OD1zNT6wOVch|ryP MmG3V2FPT0WU
CAL-120 M{mwcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTF3LkG0OFch|ryP NFTEZ3RUSU6JRWK=
COLO-824 M3fSOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzWSJVKSzVyPUG1MlE2PzlizszN M3PvUXNCVkeHUh?=
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CP66-MEL NIPE[4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDCTWM2OD1zNT60Olg5KM7:TR?= NIfHVGpUSU6JRWK=
OC-314 M3r4SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjzfXh6UUN3ME2xOU41PzF2IN88US=> NILiPGhUSU6JRWK=
OVCAR-8 NV\xTldQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPsbXJKSzVyPUG1Mlg5PjFizszN MmjyV2FPT0WU
MFE-280 NH;Ib5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTF4LkC0PFgh|ryP MkXhV2FPT0WU
MHH-NB-11 M{HEOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXtNWVKSzVyPUG2MlA5OzlizszN NXLpZpl5W0GQR1XS
SW1990 M3THSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmS4TWM2OD1zNj6xO|U2KM7:TR?= M4j1[XNCVkeHUh?=
U-266 MlL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2[4c2lEPTB;MU[uNlI6QSEQvF2= NETZNnJUSU6JRWK=
MFM-223 NXG0eIYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVO2TWlIUUN3ME2xOk4{QTZ3IN88US=> NEPjVIJUSU6JRWK=
L-363 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHUZodKSzVyPUG2MlQ2PzdizszN NFLEUJJUSU6JRWK=
MCF7 M1\tXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjZU4lUUUN3ME2xOk41PzJ|IN88US=> NGL6enBUSU6JRWK=
SK-MEL-3 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{i3UWlEPTB;MU[uOFc5PyEQvF2= NVLDXmZwW0GQR1XS
HH NWjMfZhnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTF4LkWxOlIh|ryP NHXYXYxUSU6JRWK=
no-10 NGP2TmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nkZWlEPTB;MU[uOlM1OyEQvF2= MmSyV2FPT0WU
HuP-T3 NYe3UJVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\hcWlEPTB;MU[uOlU4PiEQvF2= MUjTRW5ITVJ?
QIMR-WIL Ml7US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnoWZFKSzVyPUG2MlcyODVizszN MYPTRW5ITVJ?
NCI-H1092 Mor3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHCTWM2OD1zNj64N|E3KM7:TR?= MofnV2FPT0WU
MZ2-MEL MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTF4Lki0NFMh|ryP M2\MfnNCVkeHUh?=
ES3 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXWXW5KSzVyPUG2MlkyOzRizszN MX7TRW5ITVJ?
COLO-684 NFP3c|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnpTWM2OD1zNj65OFc4KM7:TR?= MVjTRW5ITVJ?
NCI-H661 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nybmlEPTB;MU[uPVY6PCEQvF2= MUTTRW5ITVJ?
CP50-MEL-B MnS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHO[nlKSzVyPUG3MlA{PDNizszN MWPTRW5ITVJ?
NCI-H2405 NVHKPG5IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXxcnk5UUN3ME2xO{4yQTd2IN88US=> MlftV2FPT0WU
U-2-OS NVjueY4{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvsRpJJUUN3ME2xO{42OzB5IN88US=> NWP2fGZKW0GQR1XS
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NCI-H2342 NWfKOG5bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILUR49KSzVyPUG3MlU2PyEQvF2= MWXTRW5ITVJ?
ES8 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;DTWM2OD1zNz62NFg4KM7:TR?= Ml64V2FPT0WU
MOLT-16 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPhPFM6UUN3ME2xO{45QTN2IN88US=> M3roW3NCVkeHUh?=
RH-18 M4DQTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTF6LkCwN|Uh|ryP M1TYdnNCVkeHUh?=
D-283MED NVjMUodbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXZOXROUUN3ME2xPE4xODh6IN88US=> NI\oOVlUSU6JRWK=
RCC10RGB M4rhcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTF6LkC1OVkh|ryP Ml;wV2FPT0WU
NCI-H1437 MmPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37KZ2lEPTB;MUiuNVY1OSEQvF2= M3W3fnNCVkeHUh?=
SW982 Mkj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzYTWM2OD1zOD6yOlcyKM7:TR?= M3HjTHNCVkeHUh?=
IST-MES1 M3vXZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrtOWRKSzVyPUG4MlQ1OjhizszN NVe1clJmW0GQR1XS
A704 NYDnclVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITseIRKSzVyPUG4MlQ4PTNizszN NHfMSmZUSU6JRWK=
ESS-1 Mn\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUX0Wng5UUN3ME2xPE42OjB3IN88US=> NVfBfJpsW0GQR1XS
SCH NH3pXINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfKNGdKSzVyPUG4MlY1PTZizszN M{jKRXNCVkeHUh?=
COLO-320-HSR M3i0[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rTc2lEPTB;MUiuO|Q3KM7:TR?= Mlz2V2FPT0WU
Mo-T NVX6[3ZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXqXVVKSzVyPUG4MlgzODRizszN MVTTRW5ITVJ?
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KM-H2 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTN2LkG3O|kh|ryP M2e5UHNCVkeHUh?=
NCI-H2122 M1KwNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHtU2xKSzVyPUO0MlM1PzFizszN NX;LbXAyW0GQR1XS
ABC-1 NFnHZpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn:2TWM2OD1|ND6zOlk{KM7:TR?= Mn3tV2FPT0WU
NCI-H1355 MoXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPxOWpTUUN3ME2zOE4{QDh7IN88US=> NXHae4tXW0GQR1XS
NOMO-1 NWDzR|NYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDTNpVQUUN3ME2zOE42PzB|IN88US=> NX6ySJQzW0GQR1XS
MZ7-mel M1rvR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjvTJJIUUN3ME2zOE43PDh5IN88US=> M4\ZNHNCVkeHUh?=
NCI-H810 M2nvS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TGWGlEPTB;M{SuO|I4QCEQvF2= MlK5V2FPT0WU
D-392MG M4S5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTN3LkC1OlUh|ryP Ml\LV2FPT0WU
LB771-HNC M3TvO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jFZmlEPTB;M{WuNVY2QCEQvF2= NFzk[pBUSU6JRWK=
COLO-679 NI\ofYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfFTWM2OD1|NT6zPFgh|ryP NVG5XXBRW0GQR1XS
SK-PN-DW M33vR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LqPGlEPTB;M{WuOFM3QSEQvF2= MVTTRW5ITVJ?
VA-ES-BJ NX;qT2hDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rJbGlEPTB;M{WuOFY1QSEQvF2= MXvTRW5ITVJ?
KNS-42 MlvNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{f6ZmlEPTB;M{WuOVgzPiEQvF2= NFvoU3RUSU6JRWK=
RVH-421 NIexR2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIr3PWdKSzVyPUO1Mlc3PDVizszN NFrLNJhUSU6JRWK=
P30-OHK MonJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfhT3hKSzVyPUO1Mlg4PTJizszN NUPkdlVwW0GQR1XS
G-402 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnviTWM2OD1|NT65PFY4KM7:TR?= NUL3PG05W0GQR1XS
S-117 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLnPHFKSzVyPUO2MlMxODhizszN NHLN[VlUSU6JRWK=
RXF393 M{f6cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXZSWxKSzVyPUO2MlM4QDVizszN M2K2RnNCVkeHUh?=
LCLC-103H NV;oZ4N3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{O2d2lEPTB;M{[uO|gxOyEQvF2= MYPTRW5ITVJ?
U-118-MG NHSxZYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnhVGNKSzVyPUO2Mlg5PDdizszN NH7PTWRUSU6JRWK=
8-MG-BA NYnDeZpPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTN4Lkm0PFMh|ryP MmfGV2FPT0WU
MFH-ino NVK4ZYhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTN5LkOzO|Eh|ryP MXTTRW5ITVJ?
NCI-H23 NYjDZmU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmO3TWM2OD1|Nz60NVk3KM7:TR?= MWnTRW5ITVJ?
NCI-H446 M{D5NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTN5LkS4OlIh|ryP MlnBV2FPT0WU
LU-99A NVfQSpYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDhTWM2OD1|Nz61O|MyKM7:TR?= MV3TRW5ITVJ?
KP-N-YN MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XCcWlEPTB;M{euOlE6PSEQvF2= MnzjV2FPT0WU
SCC-9 M2Trdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTN5Lke4N|gh|ryP NVLyb2NUW0GQR1XS
EFM-19 NHm1dlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIH1R4xKSzVyPUO3Mlc6PjdizszN M3PJUnNCVkeHUh?=
A427 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIe3RXFKSzVyPUO3MlkyODdizszN MUXTRW5ITVJ?
LB831-BLC NIX5Z3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDxSVlKSzVyPUO4MlYxOzlizszN NGrncnNUSU6JRWK=
HOS NGDjNGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWq5TVVOUUN3ME2zPU43Ojd|IN88US=> NFywT3lUSU6JRWK=
LAN-6 NEjDfnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTRyLkCxNVIh|ryP NYG5fYQ2W0GQR1XS
U251 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LvSWlEPTB;NECuOFA2PCEQvF2= MoniV2FPT0WU
SNU-387 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTwSlNOUUN3ME20NE41PTV|IN88US=> MV;TRW5ITVJ?
DMS-79 M3TxbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTRyLkW4PFkh|ryP MkLhV2FPT0WU
SK-LU-1 NInScHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofkTWM2OD12MD62OVY5KM7:TR?= M4fOSHNCVkeHUh?=
HT MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\DVmlEPTB;NECuOlY{QSEQvF2= Mnf5V2FPT0WU
KP-N-YS M2TQfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrXfVBGUUN3ME20NE43PzZ6IN88US=> MoDqV2FPT0WU
DMS-114 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUGxPGNiUUN3ME20NE45Ozd2IN88US=> MoPPV2FPT0WU
HUTU-80 NVjud4FkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjyTWM2OD12MT6wOVY6KM7:TR?= MlrOV2FPT0WU
ONS-76 MoPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1POSWlEPTB;NEGuOFcxQSEQvF2= NXPTcWx2W0GQR1XS
A673 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7uco9[UUN3ME20NU42OTV5IN88US=> MYDTRW5ITVJ?
HPAF-II NXnSNpE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvsTWM2OD12MT62O|A6KM7:TR?= MYDTRW5ITVJ?
UACC-257 NWK5RWtrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTRzLkezOlkh|ryP MYXTRW5ITVJ?
EW-22 MlzGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTxTWM2OD12MT64Olk4KM7:TR?= M{TCe3NCVkeHUh?=
NCI-H1755 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jYbGlEPTB;NEGuPFczPSEQvF2= MlnlV2FPT0WU
KYSE-150 NIiyOHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTR{LkG3PFIh|ryP MVjTRW5ITVJ?
CGTH-W-1 NEDkS2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGniRW9KSzVyPUSyMlQ6PTVizszN MYDTRW5ITVJ?
NB13 Mm\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHkc3VEUUN3ME20Nk43OjF5IN88US=> MnTaV2FPT0WU
SW872 NFGxSWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTR{Lk[zN|Eh|ryP MlTqV2FPT0WU
KP-4 NIjvSHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTR{Lki4N|Ih|ryP M{PadHNCVkeHUh?=
HCC38 M4njd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\VfWlEPTB;NEKuPVYyQCEQvF2= NIm2fVdUSU6JRWK=
BB49-HNC M4Dz[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XiOWlEPTB;NEOuNlM2PiEQvF2= M1HFenNCVkeHUh?=
CAL-62 MnfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rDfGlEPTB;NEOuOFAzQCEQvF2= NWq3TIIxW0GQR1XS
NCI-H2029 NYW5PJlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILI[3pKSzVyPUSzMlU2QDFizszN M4SxdXNCVkeHUh?=
M14 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmf6TWM2OD12ND6xN|MzKM7:TR?= NVjsRYpsW0GQR1XS
COLO-680N M4fsPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjm[lJTUUN3ME20OE4{OzlizszN M1fRS3NCVkeHUh?=
Hs-578-T NWXWTVY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\LU29{UUN3ME20OU4xOjl2IN88US=> Mn7RV2FPT0WU
MSTO-211H NFXHdWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Pub2lEPTB;NEWuPVQ5OiEQvF2= M3e2NHNCVkeHUh?=
EW-1 M1vJVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELvTWZKSzVyPUS1Mlk3QDlizszN NVvR[2pLW0GQR1XS
SW948 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljFTWM2OD12Nj60OFYzKM7:TR?= M2rXOXNCVkeHUh?=
NCI-H460 NG[2dW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzPWHNKSzVyPUS2MlUzOyEQvF2= M1rJcXNCVkeHUh?=
CAS-1 MnfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVmwPVdQUUN3ME20Ok44PzBzIN88US=> NXvLb4Z7W0GQR1XS
TGBC11TKB MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLLN41KSzVyPUS3MlE4PzdizszN M3e1THNCVkeHUh?=
HD-MY-Z MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXkTWM2OD12OD63PFYh|ryP NWTKfFR1W0GQR1XS
NCI-H226 M2e0Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTR7Lke3PFUh|ryP MWfTRW5ITVJ?
PA-1 NVHiOmNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDy[JRKSzVyPUS5Mlg{OzVizszN M1fFbXNCVkeHUh?=
LB2518-MEL NFzobYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUP2ZXRuUUN3ME20PU45PzJ|IN88US=> MkHNV2FPT0WU
A101D MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XMSGlEPTB;NEmuPVQzPSEQvF2= NHTjZo5USU6JRWK=
NCI-H2087 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\ofZlKSzVyPUS5Mlk3QDJizszN MkO4V2FPT0WU

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

体内試験 Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]

お薦めの試験操作(参考用のみ)

キナーゼ試験:

[1]

+ 展開

In vitro kinase activity assays:

The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.
細胞試験:

[1]

+ 展開
  • 細胞株: NSCLC cells
  • 濃度: 0-10 μM
  • 反応時間: 1 hour
  • 実験の流れ:

    1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.


    (参考用のみ)
動物試験:

[1]

+ 展開
  • 動物モデル: Athymic NMRI-nu/nu female mice
  • 製剤: In 0.5% methocellulose-0.4% polysorbate-80 (Tween 80)
  • 投薬量: 20 mg/kg
  • 投与方法: Oral administration
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
混合させたのち直ちに使用することを推奨します。
10mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 485.94
化学式

C24H25ClFN5O3

CAS No. 439081-18-2
保管
in solvent
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02780687 Recruiting Urologic Neoplasms Boehringer Ingelheim June 9 2016 Phase 2
NCT02131259 Completed Carcinoma Non-Small-Cell Lung Boehringer Ingelheim May 7 2014 --
NCT02216617 Completed HNSCC Groupe Oncologie Radiotherapie Tete et Cou August 6 2014 Phase 1
NCT02451553 Recruiting Advanced Malignant Solid Neoplasm|Bile Duct Carcinoma|Recurrent Malignant Solid Neoplasm|Recurrent Pancreatic Carcinoma|Stage III Pancreatic Cancer AJCC v6 and v7|Stage IVA Pancreatic Cancer|Stage IVB Pancreatic Cancer University of Washington|National Cancer Institute (NCI) November 5 2015 Phase 1
NCT02047903 Active not recruiting Carcinoma Non-Small-Cell Lung Boehringer Ingelheim March 5 2014 --
NCT01523587 Completed Carcinoma Non-Small-Cell Lung Boehringer Ingelheim March 5 2012 Phase 3

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答:

    For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

EGFRシグナル伝達経路

EGFR Inhibitors with Unique Features

相関EGFR製品

Tags: Afatinib (BIBW2992)を買う | Afatinib (BIBW2992) ic50 | Afatinib (BIBW2992)供給者 | Afatinib (BIBW2992)を購入する | Afatinib (BIBW2992)費用 | Afatinib (BIBW2992)生産者 | オーダーAfatinib (BIBW2992) | Afatinib (BIBW2992)化学構造 | Afatinib (BIBW2992)分子量 | Afatinib (BIBW2992)代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID