Afatinib (BIBW2992)

製品コードS1011

Afatinib (BIBW2992)化学構造

分子量(MW):485.94

Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.

サイズ 価格(税別)  
JPY 39840.00
JPY 19920.00
JPY 34860.00
JPY 94620.00

文献中Selleckの製品使用例(38)

カスタマーフィードバック(4)

  • Cytoxicity of irreversible EGFR TKIS and ethacrynic acid on breast cells lines. A, Mean IC50 value of Afatinib.

    Oncotarget, 2016, 7(36):58038-58050. Afatinib (BIBW2992) purchased from Selleck.

    Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

  • Inhibition of anchorage-independent growth of lung tumor cell lines by selected inhibitors. Each selected cell line was treated with the indicated inhibitor at 0.1 μM and 1 μM concentrations for two weeks and cell colony size formation was scored under the Nikon inverted-phase microscope.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

    After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of BIBW2992 for 3h,followed by 15-minute stimolation of 100ng/ml EGF

    Dr. Zhang of Tianjin Medical University. Afatinib (BIBW2992) purchased from Selleck.

製品安全説明書

EGFR阻害剤の選択性比較

生物活性

製品説明 Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.
ターゲット
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
ErbB4 [2]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 1 nM 10 nM 14 nM
体外試験

BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 NEPCVppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwMEC1O|Ih|ryP NFP2WnZUSU6JRWK=
KASUMI-1 NXXxSnYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfHUpZKSzVyPUCuNFA6OTFizszN MUTTRW5ITVJ?
HCC2218 M4[3WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\rW5BiUUN3ME2wMlAxQTh5IN88US=> MknyV2FPT0WU
KARPAS-45 M3OwOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XyXmlEPTB;MD6wNVY4OSEQvF2= MWrTRW5ITVJ?
HSC-4 Mlu4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwMEG3OFgh|ryP M1;5NHNCVkeHUh?=
CHL-1 M3\qOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF73R3dKSzVyPUCuNFE5OzlizszN NVz3fYpuW0GQR1XS
KY821 M1vHUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwMEKwOkDPxE1? MUPTRW5ITVJ?
NCI-N87 M{SzXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1S3O2lEPTB;MD6wNlc4OyEQvF2= NUPaNXlFW0GQR1XS
DOK MontS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwMEOxPVQh|ryP M1Ww[XNCVkeHUh?=
DSH1 NWLkVGx7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXQTWM2OD1yLkCzN|E1KM7:TR?= MlLsV2FPT0WU
MDA-MB-175-VII NFTaV2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfRTWM2OD1yLkCzOFE3KM7:TR?= NF20W2lUSU6JRWK=
NCI-H2170 NYftcogyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMEO3Nlgh|ryP MWnTRW5ITVJ?
BT-474 MmWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDSTWM2OD1yLkC0PVg3KM7:TR?= MUTTRW5ITVJ?
EFO-27 MonKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\NTWM2OD1yLkC1NVgzKM7:TR?= NVKwS2lpW0GQR1XS
NCI-H720 NYDqU|Q{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjY[XVKSzVyPUCuNFU{OjVizszN MYrTRW5ITVJ?
PC-14 NF31SGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnBc3F3UUN3ME2wMlA2PjZ6IN88US=> NXnuXoV5W0GQR1XS
EC-GI-10 NXK2UIN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPRTWM2OD1yLkC1PVEzKM7:TR?= MnPmV2FPT0WU
KYSE-450 NUn2[3dmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLmcIRKUUN3ME2wMlA2QTd6IN88US=> M4DvbXNCVkeHUh?=
BPH-1 M2rPPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;P[GlEPTB;MD6wOVk5QCEQvF2= MnfHV2FPT0WU
NCI-H292 NWT6NnNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofLTWM2OD1yLkC2NFkh|ryP MVjTRW5ITVJ?
H9 NETFVFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMEexN|Ih|ryP M2fuc3NCVkeHUh?=
NCI-H526 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\iRnkzUUN3ME2wMlA4QDJ|IN88US=> M3jXU3NCVkeHUh?=
NCI-H1623 NFHzc2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnSR5hKSzVyPUCuNFgxOjVizszN M{GzS3NCVkeHUh?=
KYSE-140 NWH2[HpRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoP6TWM2OD1yLkC4N|Mh|ryP NXzVeWp5W0GQR1XS
Ca9-22 NFfHO5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjiZmN{UUN3ME2wMlA5OzV|IN88US=> NX3QWml7W0GQR1XS
AU565 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTBwMEi1NFQh|ryP MYnTRW5ITVJ?
ZR-75-30 M3WxRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moj0TWM2OD1yLkC5OVQ2KM7:TR?= M2Sz[XNCVkeHUh?=
NCI-H1770 M1fDZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF36bXdKSzVyPUCuNVAzQCEQvF2= NYj0VI9FW0GQR1XS
LB2241-RCC MnLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;6TWM2OD1yLkGwPFg1KM7:TR?= M{OyN3NCVkeHUh?=
CAL-39 NVfUVHhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HxTmlEPTB;MD6xNVc6OiEQvF2= MkThV2FPT0WU
UACC-893 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\zRmR[UUN3ME2wMlEyQDh3IN88US=> NVPpWZpHW0GQR1XS
LU-65 NIfJUINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHYW3NMUUN3ME2wMlEzPjN|IN88US=> M1L0e3NCVkeHUh?=
HN MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDhTWM2OD1yLkGzNFc4KM7:TR?= NI\Kb5ZUSU6JRWK=
TI-73 Mmr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\kVoRKSzVyPUCuNVQ4OTVizszN M{XoTXNCVkeHUh?=
KU812 MofXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{i1UmlEPTB;MD6xOVQ2PiEQvF2= M4DPc3NCVkeHUh?=
SW13 NGe5RXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moq3TWM2OD1yLkG2NlE3KM7:TR?= M3nmNXNCVkeHUh?=
BB30-HNC M3X2[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vW[2lEPTB;MD6xOlU4PiEQvF2= M3nIcXNCVkeHUh?=
HSC-2 NXnMWYczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nKemlEPTB;MD6xOlg{PyEQvF2= M4n1N3NCVkeHUh?=
BV-173 MlzDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMUe1PVYh|ryP M1nV[HNCVkeHUh?=
CAL-27 NWLHW3J6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPQU2xKSzVyPUCuNVc3OzZizszN NVfXNZhWW0GQR1XS
SBC-1 NXXGcoJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwMUi5OVkh|ryP MXTTRW5ITVJ?
CAL-33 NWezbXRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjSTWM2OD1yLkKwNVg1KM7:TR?= NV7aVYdSW0GQR1XS
NCI-H209 NYDrWnh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXPXWhKSzVyPUCuNlA1PiEQvF2= MkjZV2FPT0WU
COR-L105 NWTUS|hqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIL0NFlKSzVyPUCuNlExQDRizszN NWjLW2U6W0GQR1XS
HSC-3 M17vUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMkGxPVgh|ryP Mn7KV2FPT0WU
NCI-H69 NV\pSpB7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFeyXVVKSzVyPUCuNlE1PTFizszN NXfKTHdTW0GQR1XS
MOLT-13 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwMkO5O|Uh|ryP MoG2V2FPT0WU
ML-2 NWHObpBuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHscG5KSzVyPUCuNlQ5ODJizszN NX2yWZJuW0GQR1XS
IGROV-1 NV7qUoZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrlcVhPUUN3ME2wMlI2QTV{IN88US=> NVm2TmpXW0GQR1XS
TK10 M3;0fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwMk[3N|gh|ryP MXzTRW5ITVJ?
EoL-1-cell NHfh[WpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvsTWM2OD1yLkK2PFkzKM7:TR?= MWnTRW5ITVJ?
HO-1-N-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7jTWM2OD1yLkK3PFU{KM7:TR?= MUHTRW5ITVJ?
BHY MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml25TWM2OD1yLkK4OlU2KM7:TR?= NXTDTJpNW0GQR1XS
LU-139 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTpTWM2OD1yLkOwOVEh|ryP MYLTRW5ITVJ?
23132-87 NUTrbJliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoX3TWM2OD1yLkOxPVI{KM7:TR?= M{nhTHNCVkeHUh?=
ACHN NFPYbY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnaTWM2OD1yLkOxPVk1KM7:TR?= MYPTRW5ITVJ?
DoTc2-4510 MlPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwM{KyNVkh|ryP MVrTRW5ITVJ?
BB65-RCC MoPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFv2UFdKSzVyPUCuN|Q2QTNizszN NE\5SIdUSU6JRWK=
HLE M4nVT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPlTWM2OD1yLkO1NFQ3KM7:TR?= NVOzPVRpW0GQR1XS
HCC1419 MlvOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{WxVWlEPTB;MD6zOlQxQCEQvF2= NIHuWpNUSU6JRWK=
A388 Mn;kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHUd|VKSzVyPUCuN|Y5PTdizszN MlL5V2FPT0WU
NUGC-3 NF62T3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DUcmlEPTB;MD6zPFM4OyEQvF2= M{fjZnNCVkeHUh?=
KYSE-180 MmLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwM{mwPFkh|ryP NIfRRpRUSU6JRWK=
TE-6 NH;wSXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjITWM2OD1yLkSwNlQ3KM7:TR?= NGr0b2hUSU6JRWK=
A498 NUj5UXdRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwNEC2O|Qh|ryP MWfTRW5ITVJ?
NCI-H1648 M1e2T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPqTWM2OD1yLkS0NVgzKM7:TR?= NVPpTpA2W0GQR1XS
DU-145 NFfzVoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwNES4N|Mh|ryP NGLCe5BUSU6JRWK=
CW-2 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkOzTWM2OD1yLkS2PVE1KM7:TR?= NGmyOFdUSU6JRWK=
A431 NVrtZZA5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwNEiyN|Mh|ryP NVTsPWw6W0GQR1XS
SAS NVLDflBRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfGbYhXUUN3ME2wMlQ5Ozl6IN88US=> M4rlNXNCVkeHUh?=
NCI-H2126 NFLFOWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlj6TWM2OD1yLkWxPVI3KM7:TR?= MV\TRW5ITVJ?
NCI-H358 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwNUOyNUDPxE1? MnziV2FPT0WU
FADU MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojtTWM2OD1yLkW0OFA1KM7:TR?= M1ztfXNCVkeHUh?=
ACN NXPhOnBpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHaNlJKSzVyPUCuOVUxQTRizszN MVXTRW5ITVJ?
HCC70 NVLDfWx5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwNUe2OlEh|ryP NYfGNYZjW0GQR1XS
NCI-H1838 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHtdGo5UUN3ME2wMlYxOjl7IN88US=> MWfTRW5ITVJ?
CAL-54 NFe1VXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3kUnJKSzVyPUCuOlE3OjFizszN NVrXNG04W0GQR1XS
NCI-H1975 NGTZdWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1Pte2lEPTB;MD62NVczQCEQvF2= NF:4UGpUSU6JRWK=
COR-L88 NWLYZZNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PMSGlEPTB;MD62OFEyOyEQvF2= MkXtV2FPT0WU
CTV-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwNkSzPVIh|ryP M2LSc3NCVkeHUh?=
EW-18 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHUToxuUUN3ME2wMlY5Pjl6IN88US=> M1zFdnNCVkeHUh?=
HCC1806 Ml\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfmN5BKSzVyPUCuOlk3PjZizszN M1XEeXNCVkeHUh?=
HuP-T4 NGrPR5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTMTWM2OD1yLk[5O|Yh|ryP NWTL[mJ[W0GQR1XS
MDA-MB-361 M2PJT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwN{K2OlIh|ryP NWf0VVhDW0GQR1XS
NCI-H1573 M3zjOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwN{O2N{DPxE1? NIHhdZpUSU6JRWK=
KU-19-19 NGLk[|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;0[YQ1UUN3ME2wMlc4PDZ2IN88US=> MmPTV2FPT0WU
COLO-678 NHLVemlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwOEC4N|Qh|ryP NIPT[4lUSU6JRWK=
C-33-A M1GzN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTZUHhTUUN3ME2wMlgyOjl5IN88US=> MkfWV2FPT0WU
Calu-3 MlLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwOEG0N|Qh|ryP NELldIJUSU6JRWK=
AGS NYruUHdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\GfWlEPTB;MD64N|Y1QCEQvF2= NYrxVIRWW0GQR1XS
SCC-25 M1HnWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrYPGZKSzVyPUCuPFQyPzFizszN MkLoV2FPT0WU
JVM-2 MofLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXlTFlKSzVyPUCuPFgzQTlizszN NEi5cphUSU6JRWK=
HCE-T MnOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\Te2lEPTB;MD64PFQzQCEQvF2= NVP1emFnW0GQR1XS
ES4 M1zze2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LjdWlEPTB;MD65O|g{PiEQvF2= MY\TRW5ITVJ?
EKVX NIf3fYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnj3TWM2OD1zLkCxNFY1KM7:TR?= NGnOZ3NUSU6JRWK=
D-542MG MlXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1e4ZWlEPTB;MT6wNVA3PCEQvF2= Ml7ZV2FPT0WU
SW1116 MoLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofYTWM2OD1zLkCxNlg4KM7:TR?= MoTnV2FPT0WU
5637 MknTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTFwMEG1NUDPxE1? NV3MVGVSW0GQR1XS
HT-1376 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzSeJNKSzVyPUGuNFE2OTNizszN NI\3ZVhUSU6JRWK=
NB69 NGeyTIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTFwMEK5OFUh|ryP NWDlNVM{W0GQR1XS
YKG-1 NFTCPI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\rNYpQUUN3ME2xMlA2PDF7IN88US=> NWLrRo5MW0GQR1XS
EW-3 MlfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTFwMEe4PFMh|ryP NXvjPYpQW0GQR1XS
GCIY NWfMVYJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTFwMEixNFQh|ryP MYDTRW5ITVJ?
SK-MES-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPVS41KSzVyPUGuNVE1QDdizszN NHXqe|BUSU6JRWK=
PANC-08-13 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEj4dHlKSzVyPUGuNVY1OTZizszN NXXRclZ5W0GQR1XS
SK-NEP-1 NVTNbpM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojWTWM2OD1zLkG3OVE{KM7:TR?= NUPmXmcyW0GQR1XS
SW954 NWL2[mF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYf0OnJrUUN3ME2xMlIxOjF2IN88US=> NXnobo5FW0GQR1XS
NCI-SNU-5 NHLaSGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDzW5RKSzVyPUGuNlM6KM7:TR?= NXLkUZRqW0GQR1XS
SW48 M2DUO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;jTWM2OD1zLkK1OFMzKM7:TR?= Mly5V2FPT0WU
HT-3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTSc242UUN3ME2xMlI5PzV|IN88US=> Ml3EV2FPT0WU
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SW900 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TDcGlEPTB;Nz64NlEzOSEQvF2= MoLZV2FPT0WU
JVM-3 M2PG[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTdwOEm1PVkh|ryP Mn;LV2FPT0WU
OAW-28 NH22b2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LxNWlEPTB;Nz65OFU4QCEQvF2= NVTTbGV{W0GQR1XS
KURAMOCHI MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW[4N|NoUUN3ME23Mlk1QDFzIN88US=> NYe0VJk5W0GQR1XS
BE-13 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTdwOUixNVIh|ryP NGLDdYJUSU6JRWK=
VMRC-RCZ M4joXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjKTWM2OD16LkCxOlk4KM7:TR?= MV;TRW5ITVJ?
NCI-H727 M335d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzZN2UxUUN3ME24MlExPDJizszN MmH1V2FPT0WU
SW1710 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{WzTmlEPTB;OD6xPFUyPSEQvF2= NXP2c5FPW0GQR1XS
D-502MG NFjidI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPBcHRKSzVyPUiuNlkzQDJizszN MY\TRW5ITVJ?
NCI-H1993 NGnDXWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3n5[GlEPTB;OD6zN|Y{OSEQvF2= MX;TRW5ITVJ?
SCC-4 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1K3SmlEPTB;OD60OFA2QSEQvF2= MV;TRW5ITVJ?
HAL-01 Mo\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3JTWM2OD16LkWxPVEh|ryP NXP6WmVUW0GQR1XS
GT3TKB MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnr0TWM2OD16Lk[3PVY1KM7:TR?= MWDTRW5ITVJ?
SK-OV-3 MkLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\qXVB3UUN3ME24MlcyOzJ7IN88US=> NHH4ZVFUSU6JRWK=
COLO-829 NHf2WGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPsTWM2OD16LkiwPVc3KM7:TR?= MYXTRW5ITVJ?
OCI-AML2 NYnpSZdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRThwOUW0PFEh|ryP M3\GVnNCVkeHUh?=
OS-RC-2 MmLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLiXm5CUUN3ME25MlAzOTlizszN MXjTRW5ITVJ?
BFTC-909 NXvtZZF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDQTWM2OD17LkC2O|k6KM7:TR?= MlzkV2FPT0WU
EW-11 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmKwTWM2OD17LkG3OlU{KM7:TR?= MlzwV2FPT0WU
HCE-4 M1LmSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTlwMkG1OVgh|ryP NUfvNIxLW0GQR1XS
BALL-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDpTWM2OD17LkKxPVA4KM7:TR?= NXfqOFhjW0GQR1XS
SF539 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzsZZdKSzVyPUmuNlM2PjJizszN MX\TRW5ITVJ?
CAMA-1 M3PBfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnNZpdVUUN3ME25MlI5OTJ6IN88US=> MUXTRW5ITVJ?
C32 MlqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPpSWhWUUN3ME25MlM{ODZ2IN88US=> NUj5fWEyW0GQR1XS
NCI-H1703 NYS3TFdGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\ZbmlEPTB;OT6zOFM4PSEQvF2= NGDTbZZUSU6JRWK=
NCI-H1650 M4\YPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPrRYJRUUN3ME25MlYxQTR4IN88US=> NX;h[m1CW0GQR1XS
NCI-H1563 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfBVYRmUUN3ME25Mlc3ODNzIN88US=> MYjTRW5ITVJ?
CAL-85-1 NWjMS49jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2H2U2lEPTB;OT64O|M5OyEQvF2= M4XOe3NCVkeHUh?=
UM-UC-3 MoPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIT5eJFKSzVyPUmuPVUxOyEQvF2= NUH5TJBrW0GQR1XS
BxPC-3 MljyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{f5TGlEPTB;MUCuNFk4OiEQvF2= NVHCZXhOW0GQR1XS
MHH-PREB-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TCPWlEPTB;MUCuNVk6QSEQvF2= NVTIV5pGW0GQR1XS
DEL NIHtcYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTFyLkO5OFYh|ryP NUH3[ml[W0GQR1XS
HuCCT1 M3zYfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnpdJpKSzVyPUGwMlYxOzNizszN M33zdnNCVkeHUh?=
OVCAR-4 Mn72S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TVWWlEPTB;MUCuPFg{PSEQvF2= M1nFU3NCVkeHUh?=
CAL-72 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TZUGlEPTB;MUCuPVM6OSEQvF2= NYHWflVwW0GQR1XS
HCC1954 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfVVoR{UUN3ME2xNU4xPzV2IN88US=> M2PRfXNCVkeHUh?=
EFO-21 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTFzLkGwOFUh|ryP MnjmV2FPT0WU
FTC-133 NWe2bWs{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjlOJNKSzVyPUGxMlE1ODdizszN MkDkV2FPT0WU
SK-MEL-24 NVfoT|lIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2X3TGlEPTB;MUGuNlM3PiEQvF2= MnjPV2FPT0WU
UACC-62 NFvmWI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTFzLkKzOlgh|ryP NEnuR4RUSU6JRWK=
NCI-H650 MoX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorSTWM2OD1zMT6yOFE5KM7:TR?= MoTjV2FPT0WU
ALL-PO MkjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTFzLkK1NVIh|ryP MnnMV2FPT0WU
T84 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTrOmUzUUN3ME2xNU4{QTB5IN88US=> MX3TRW5ITVJ?
IST-MEL1 MnLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HiSmlEPTB;MUGuOFU2QSEQvF2= MWrTRW5ITVJ?
SW626 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXES|FKSzVyPUGxMlU4PTVizszN NFzhRm1USU6JRWK=
RPMI-2650 NGrVcmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUL1eZd1UUN3ME2xNU42QDh3IN88US=> NUKzR4VvW0GQR1XS
MC-IXC M1XHemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXOPXBWUUN3ME2xNU43PzJ6IN88US=> MnG3V2FPT0WU
HOP-62 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTFzLk[3OlQh|ryP NWfWU3RKW0GQR1XS
NOS-1 NWPlUFkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTFzLkexNFkh|ryP NWfoWpNWW0GQR1XS
SW1573 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTFzLkeyPVUh|ryP MXnTRW5ITVJ?
WM-115 NVTZWXVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPre5QxUUN3ME2xNU44PTh6IN88US=> M2PpUHNCVkeHUh?=
HuO9 NWf0VGpWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTFzLki3O|Qh|ryP MWTTRW5ITVJ?
YAPC NIK1[GlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGCyVotKSzVyPUGxMlkzPTlizszN M4LUUHNCVkeHUh?=
MDA-MB-453 NHL3XVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTJNm5rUUN3ME2xNU46PTF3IN88US=> NIjybmNUSU6JRWK=
NCI-H596 NF34SmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTF{LkCzOlkh|ryP NFLiSYxUSU6JRWK=
A172 M1PaS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnPO|lKSzVyPUGyMlA4QThizszN M2j2R3NCVkeHUh?=
RS4-11 M1LsXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLPT5pEUUN3ME2xNk4yPzJ3IN88US=> Mm[2V2FPT0WU
HCC1937 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTF{Lke1OlQh|ryP MVXTRW5ITVJ?
SW837 NWLvNG9pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTDWFg2UUN3ME2xNk46ODJ6IN88US=> NEnUbmdUSU6JRWK=
NMC-G1 NIL0UpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTF{LkmyN|Qh|ryP MlzEV2FPT0WU
PFSK-1 MmjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1f1cmlEPTB;MUOuNFYh|ryP M4nIc3NCVkeHUh?=
DBTRG-05MG MkfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHL5PVlKSzVyPUGzMlA3OzJizszN NH65[phUSU6JRWK=
SK-UT-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV:2NJVNUUN3ME2xN{4yODh|IN88US=> NUGyOXRVW0GQR1XS
OVCAR-5 MnTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmGwTWM2OD1zMz6xOVk{KM7:TR?= MU\TRW5ITVJ?
8505C NYPNcoxNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTF|LkKwOlch|ryP NGntZlNUSU6JRWK=
SK-MEL-1 NVLacY5ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTF|LkexN|Uh|ryP M{\QSnNCVkeHUh?=
LK-2 NV\V[5A3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTZeZFKSzVyPUGzMlc3OzlizszN NXe3foRDW0GQR1XS
OE33 NHK3N5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLJfIpKSzVyPUGzMlc5PiEQvF2= NV7D[JpvW0GQR1XS
Ramos-2G6-4C10 NXnYVZRzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnwOpc3UUN3ME2xOE4xOjB{IN88US=> M17ZcXNCVkeHUh?=
EW-13 MkjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHOxT|lKSzVyPUG0MlA{PTJizszN MljHV2FPT0WU
NCI-H1793 M2CwO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\nNYpKSzVyPUG0MlIxQDdizszN M4nXR3NCVkeHUh?=
BHT-101 NEXWNHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTF2LkK0NUDPxE1? M1nPNXNCVkeHUh?=
RKO M3HiXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnTW5pKSzVyPUG0MlUxPzVizszN MkD1V2FPT0WU
NEC8 NX7iUWJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LnZmlEPTB;MUSuOVQ4OiEQvF2= NYj0OGVZW0GQR1XS
PANC-10-05 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGqxN|hKSzVyPUG0MlYzPDdizszN M4W2cXNCVkeHUh?=
NCI-H2030 MlLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPsTWM2OD1zND62OFQ5KM7:TR?= M4jvVnNCVkeHUh?=
C2BBe1 NV;tPZdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDsO5ZKSzVyPUG0Mlc3PCEQvF2= MYDTRW5ITVJ?
EM-2 M3LDPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTF2Lki1O|Yh|ryP NIPDPZhUSU6JRWK=
HCC1395 NYC1RWd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoSyTWM2OD1zND65N|M5KM7:TR?= M2nheXNCVkeHUh?=
A2058 M{XtPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXuTWM2OD1zNT6wOFA6KM7:TR?= NXra[5BIW0GQR1XS
SW1463 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vuVmlEPTB;MUWuNFQ5PSEQvF2= M2TLcnNCVkeHUh?=
J82 M1fhZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnv0TWM2OD1zNT6wOVch|ryP NFuwboVUSU6JRWK=
CAL-120 NFrDNJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTF3LkG0OFch|ryP NIrLT3NUSU6JRWK=
COLO-824 M3LoR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonQTWM2OD1zNT6xOVc6KM7:TR?= NWjuZnl[W0GQR1XS
LNCaP-Clone-FGC NEnoSHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTF3LkSyOFgh|ryP MnjKV2FPT0WU
CP66-MEL MnXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLHTWM2OD1zNT60Olg5KM7:TR?= NUXTZ2pkW0GQR1XS
OC-314 M3T1VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3NO2NKSzVyPUG1MlQ4OTRizszN MVTTRW5ITVJ?
OVCAR-8 NW\iU3JyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPIfWlKUUN3ME2xOU45QDZzIN88US=> MYTTRW5ITVJ?
MFE-280 NUna[Yh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrC[WZKSzVyPUG2MlA1QDhizszN M1nW[HNCVkeHUh?=
MHH-NB-11 M4fXb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIC2V|NKSzVyPUG2MlA5OzlizszN MkHuV2FPT0WU
SW1990 NIS0bHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTF4LkG3OVUh|ryP NXnXSIRiW0GQR1XS
U-266 NH;oN|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DLOmlEPTB;MU[uNlI6QSEQvF2= M1PlTnNCVkeHUh?=
MFM-223 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH32SGhKSzVyPUG2MlM6PjVizszN NIXiWINUSU6JRWK=
L-363 M2i2cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Xl[mlEPTB;MU[uOFU4PyEQvF2= MkDCV2FPT0WU
MCF7 M1fzPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYntT|ZVUUN3ME2xOk41PzJ|IN88US=> NWHuTnhYW0GQR1XS
SK-MEL-3 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3xSWtrUUN3ME2xOk41Pzh5IN88US=> Mn60V2FPT0WU
HH MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF2zUFRKSzVyPUG2MlUyPjJizszN M3nYfXNCVkeHUh?=
no-10 MoDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYriUmZ1UUN3ME2xOk43OzR|IN88US=> MmizV2FPT0WU
HuP-T3 NULsVlVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1X0R2lEPTB;MU[uOlU4PiEQvF2= MXPTRW5ITVJ?
QIMR-WIL NWD4[o5oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rTSWlEPTB;MU[uO|ExPSEQvF2= NH3wWG1USU6JRWK=
NCI-H1092 Mkn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXWcZo3UUN3ME2xOk45OzF4IN88US=> M3Ta[3NCVkeHUh?=
MZ2-MEL NH3NSnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzBTWM2OD1zNj64OFA{KM7:TR?= NYrpV4xwW0GQR1XS
ES3 M{XX[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoW4TWM2OD1zNj65NVM1KM7:TR?= NVLIbVJtW0GQR1XS
COLO-684 NU\PbndZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mni3TWM2OD1zNj65OFc4KM7:TR?= M2nwZnNCVkeHUh?=
NCI-H661 NYP4VpN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELjcVFKSzVyPUG2Mlk3QTRizszN MmHYV2FPT0WU
CP50-MEL-B MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3INlNTUUN3ME2xO{4xOzR|IN88US=> Mn;FV2FPT0WU
NCI-H2405 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDSTWM2OD1zNz6xPVc1KM7:TR?= M4r5Z3NCVkeHUh?=
U-2-OS M1WzUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTF5LkWzNFch|ryP NGWw[o5USU6JRWK=
RERF-LC-MS NIq1T2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlezTWM2OD1zNz61OVA5KM7:TR?= Mk\mV2FPT0WU
NCI-H2342 NEX0OHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jlNGlEPTB;MUeuOVU4KM7:TR?= MlLMV2FPT0WU
ES8 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTF5Lk[wPFch|ryP NVPZPGFLW0GQR1XS
MOLT-16 MlXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknhTWM2OD1zNz64PVM1KM7:TR?= NYnwXplQW0GQR1XS
RH-18 MoDsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnmUWhHUUN3ME2xPE4xODN3IN88US=> NFvCTmtUSU6JRWK=
D-283MED MkXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTF6LkCwPFgh|ryP NEPsNWVUSU6JRWK=
RCC10RGB NEDudFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWO4NHJDUUN3ME2xPE4xPTV7IN88US=> MWPTRW5ITVJ?
NCI-H1437 Mkm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfHTHBKSzVyPUG4MlE3PDFizszN NX36d|dnW0GQR1XS
SW982 NFHObIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTF6LkK2O|Eh|ryP MVLTRW5ITVJ?
IST-MES1 M2q1Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTF6LkS0Nlgh|ryP MW\TRW5ITVJ?
A704 NVLVSGE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjTTWM2OD1zOD60O|U{KM7:TR?= NHvxTIRUSU6JRWK=
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SCH M4LCN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEOyfIFKSzVyPUG4MlY1PTZizszN MWTTRW5ITVJ?
COLO-320-HSR NXH4UmY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXwO5c4UUN3ME2xPE44PDZizszN NF;RcYlUSU6JRWK=
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22RV1 NHux[GFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTN2LkG3OVQh|ryP NX\UZldxW0GQR1XS
KM-H2 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3OycWlEPTB;M{SuNVc4QSEQvF2= NIro[m9USU6JRWK=
NCI-H2122 M1LPUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnz[2psUUN3ME2zOE4{PDdzIN88US=> MoXrV2FPT0WU
ABC-1 NXLNVVNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHny[mpKSzVyPUO0MlM3QTNizszN NHrq[YVUSU6JRWK=
NCI-H1355 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTN2LkO4PFkh|ryP MV7TRW5ITVJ?
NOMO-1 NHj5dotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlO2TWM2OD1|ND61O|A{KM7:TR?= M2XZWXNCVkeHUh?=
MZ7-mel NWLidWU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIO3O|dKSzVyPUO0MlY1QDdizszN NHHsfFNUSU6JRWK=
NCI-H810 NIfpfFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjGdmJiUUN3ME2zOE44Ojd6IN88US=> MkDnV2FPT0WU
D-392MG NFW3ZVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLITWM2OD1|NT6wOVY2KM7:TR?= MUTTRW5ITVJ?
LB771-HNC M3\QS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmW1TWM2OD1|NT6xOlU5KM7:TR?= NXPvNmRsW0GQR1XS
COLO-679 NGixVnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3pOYFbUUN3ME2zOU4{QDhizszN MVXTRW5ITVJ?
SK-PN-DW MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnuemdKSzVyPUO1MlQ{PjlizszN M{izOHNCVkeHUh?=
VA-ES-BJ NGjUWJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknRTWM2OD1|NT60OlQ6KM7:TR?= NHTFNVVUSU6JRWK=
KNS-42 MkPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDpUZZGUUN3ME2zOU42QDJ4IN88US=> NYey[mVyW0GQR1XS
RVH-421 NXjWW5ZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTvNnVxUUN3ME2zOU44PjR3IN88US=> MlrXV2FPT0WU
P30-OHK NFXCTHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPISZhFUUN3ME2zOU45PzV{IN88US=> MknVV2FPT0WU
G-402 M4f1fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTN3Lkm4Olch|ryP M1HS[XNCVkeHUh?=
S-117 M{LUSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvKTWM2OD1|Nj6zNFA5KM7:TR?= MnPVV2FPT0WU
RXF393 NHTLTm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfDTWM2OD1|Nj6zO|g2KM7:TR?= M{nkRXNCVkeHUh?=
LCLC-103H NXfaOHVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PVN2lEPTB;M{[uO|gxOyEQvF2= NIXaVWFUSU6JRWK=
U-118-MG MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3lZ5pKSzVyPUO2Mlg5PDdizszN MUXTRW5ITVJ?
8-MG-BA NWj5OVIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fDfmlEPTB;M{[uPVQ5OyEQvF2= MXjTRW5ITVJ?
MFH-ino MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjuSW1KSzVyPUO3MlM{PzFizszN NX7xXGZyW0GQR1XS
NCI-H23 NEPWRoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTN5LkSxPVYh|ryP MnLxV2FPT0WU
NCI-H446 NUjPdVkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTN5LkS4OlIh|ryP MnPMV2FPT0WU
LU-99A MkTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPocJNMUUN3ME2zO{42PzNzIN88US=> MWnTRW5ITVJ?
KP-N-YN NF;FUldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLmTWM2OD1|Nz62NVk2KM7:TR?= M2TX[XNCVkeHUh?=
SCC-9 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTN5Lke4N|gh|ryP MU\TRW5ITVJ?
EFM-19 NF;OUXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoCxTWM2OD1|Nz63PVY4KM7:TR?= MXzTRW5ITVJ?
A427 NXfG[GtQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fY[GlEPTB;M{euPVExPyEQvF2= MljzV2FPT0WU
LB831-BLC M2TmSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDuTWM2OD1|OD62NFM6KM7:TR?= M4X1fXNCVkeHUh?=
HOS NITIO|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXmze25NUUN3ME2zPU43Ojd|IN88US=> NE[yS3BUSU6JRWK=
LAN-6 NVfVOlhKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rDNWlEPTB;NECuNFEyOiEQvF2= MV\TRW5ITVJ?
U251 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3kdmRHUUN3ME20NE41ODV2IN88US=> MXPTRW5ITVJ?
SNU-387 MnPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjjPVZKSzVyPUSwMlQ2PTNizszN M3jkTnNCVkeHUh?=
DMS-79 MnXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TjWmlEPTB;NECuOVg5QSEQvF2= M1izUnNCVkeHUh?=
SK-LU-1 M4DoR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;LSWlEPTB;NECuOlU3QCEQvF2= NVjvc2ZtW0GQR1XS
HT Ml73S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mni1TWM2OD12MD62OlM6KM7:TR?= NYrQUVV{W0GQR1XS
KP-N-YS NXfqTphlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH25Z5JKSzVyPUSwMlY4PjhizszN MXjTRW5ITVJ?
DMS-114 MkjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfpTWM2OD12MD64N|c1KM7:TR?= M3;4RXNCVkeHUh?=
HUTU-80 M2Czc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYG3[nExUUN3ME20NU4xPTZ7IN88US=> M{jhRXNCVkeHUh?=
ONS-76 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYCzbHc5UUN3ME20NU41PzB7IN88US=> MoTpV2FPT0WU
A673 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn:xTWM2OD12MT61NVU4KM7:TR?= NHTTUplUSU6JRWK=
HPAF-II MnTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTRzLk[3NFkh|ryP M17aUHNCVkeHUh?=
UACC-257 NEPoSlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojMTWM2OD12MT63N|Y6KM7:TR?= NELybIRUSU6JRWK=
EW-22 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\p[JBKSzVyPUSxMlg3QTdizszN MkL4V2FPT0WU
NCI-H1755 NXX4WpZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHPTWM2OD12MT64O|I2KM7:TR?= NX7McGJmW0GQR1XS
KYSE-150 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHLTWM2OD12Mj6xO|gzKM7:TR?= M{K1S3NCVkeHUh?=
CGTH-W-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX:3O4dJUUN3ME20Nk41QTV3IN88US=> NYfvNIQzW0GQR1XS
NB13 NHqzN5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HOTGlEPTB;NEKuOlIyPyEQvF2= M1jBeHNCVkeHUh?=
SW872 NWfpZ|RkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorTTWM2OD12Mj62N|MyKM7:TR?= M2TsV3NCVkeHUh?=
KP-4 MnTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrMTWM2OD12Mj64PFMzKM7:TR?= NX7MTJBIW0GQR1XS
HCC38 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HQdmlEPTB;NEKuPVYyQCEQvF2= MnjrV2FPT0WU
BB49-HNC MlT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWD3VVV6UUN3ME20N{4zOzV4IN88US=> NGHjN21USU6JRWK=
CAL-62 MkDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDucWpKSzVyPUSzMlQxOjhizszN NXPsSW5KW0GQR1XS
NCI-H2029 M4L3TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfYTXplUUN3ME20N{42PThzIN88US=> MmOzV2FPT0WU
M14 M1v3cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\v[WlEPTB;NESuNVM{OiEQvF2= NWTLWZRTW0GQR1XS
COLO-680N M3vhO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTR2LkOzPUDPxE1? M364fnNCVkeHUh?=
Hs-578-T MkX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTEWmRoUUN3ME20OU4xOjl2IN88US=> MmTRV2FPT0WU
MSTO-211H NWfG[mkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33RS2lEPTB;NEWuPVQ5OiEQvF2= NVnqWWJ3W0GQR1XS
EW-1 NVHVdnR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfITWM2OD12NT65Olg6KM7:TR?= MV;TRW5ITVJ?
SW948 Mnn3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm[zTWM2OD12Nj60OFYzKM7:TR?= MnPWV2FPT0WU
NCI-H460 NGizPGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3qfFFKSzVyPUS2MlUzOyEQvF2= NHr4dmdUSU6JRWK=
CAS-1 NFvkSG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHHTWM2OD12Nj63O|AyKM7:TR?= MorKV2FPT0WU
TGBC11TKB MmnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzSTpQ2UUN3ME20O{4yPzd5IN88US=> NGXaSnVUSU6JRWK=
HD-MY-Z M4PuUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTR6Lke4OkDPxE1? MXPTRW5ITVJ?
NCI-H226 M1\yOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm[wTWM2OD12OT63O|g2KM7:TR?= MWfTRW5ITVJ?
PA-1 M2PSbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjxXItKSzVyPUS5Mlg{OzVizszN M{\OTXNCVkeHUh?=
LB2518-MEL Ml3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7MTWM2OD12OT64O|I{KM7:TR?= MVTTRW5ITVJ?
A101D MoDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETYVpNKSzVyPUS5Mlk1OjVizszN NVjoemZGW0GQR1XS
NCI-H2087 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nJSGlEPTB;NEmuPVY5OiEQvF2= MkiyV2FPT0WU

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

体内試験 Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]

お薦めの試験操作(参考用のみ)

キナーゼ試験:

[1]

+ 展開

In vitro kinase activity assays:

The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.
細胞試験:

[1]

+ 展開
  • 細胞株: NSCLC cells
  • 濃度: 0-10 μM
  • 反応時間: 1 hour
  • 実験の流れ:

    1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.


    (参考用のみ)
動物試験:

[1]

+ 展開
  • 動物モデル: Athymic NMRI-nu/nu female mice
  • 製剤: In 0.5% methocellulose-0.4% polysorbate-80 (Tween 80)
  • 投薬量: 20 mg/kg
  • 投与方法: Oral administration
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
混合させたのち直ちに使用することを推奨します。
10mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 485.94
化学式

C24H25ClFN5O3

CAS No. 439081-18-2
保管
in solvent
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03727724 Not yet recruiting Carcinoma Non-Small-Cell Lung The Netherlands Cancer Institute|Boehringer Ingelheim|Merck Serono International SA November 2018 Phase 2
NCT03695510 Not yet recruiting Head and Neck Neoplasms National Taiwan University Hospital November 2018 Phase 2
NCT03652233 Not yet recruiting Recurrent Squamous Cell Carcinoma of the Head or Neck|Platinum- and Cetuximab-Refractory Squamous Cell Carcinoma of the Head or Neck|Metastatic Squamous Cell Carcinoma of the Head or Neck|Squamous Cell Carcinoma Vanderbilt-Ingram Cancer Center|National Comprehensive Cancer Network|Boehringer Ingelheim November 2018 Phase 1
NCT03711422 Not yet recruiting Non-small Cell Lung Cancer|Leptomeningeal Disease|Central Nervous System Metastases National Cancer Centre Singapore October 2018 Phase 1
NCT03574402 Not yet recruiting Carcinoma Non-Small-Cell Lung Guangdong Association of Clinical Trials July 1 2018 Phase 2
NCT03083678 Recruiting Chordoma Leiden University Medical Center|Chordoma Foundation|Boehringer Ingelheim June 21 2018 Phase 2

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答:

    For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

EGFRシグナル伝達経路

EGFR Inhibitors with Unique Features

相関EGFR製品

Tags: Afatinib (BIBW2992)を買う | Afatinib (BIBW2992) ic50 | Afatinib (BIBW2992)供給者 | Afatinib (BIBW2992)を購入する | Afatinib (BIBW2992)費用 | Afatinib (BIBW2992)生産者 | オーダーAfatinib (BIBW2992) | Afatinib (BIBW2992)化学構造 | Afatinib (BIBW2992)分子量 | Afatinib (BIBW2992)代理店
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