Afatinib (BIBW2992)

製品コードS1011

Afatinib (BIBW2992)化学構造

分子量(MW):485.94

Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.

サイズ 価格(税別)  
JPY 39840.00
JPY 19920.00
JPY 34860.00
JPY 94620.00

文献中Selleckの製品使用例(38)

カスタマーフィードバック(5)

  • Immunoblot analysis of serum starved H2030 cells pre-treated with 500 nM or 1 µM of gefitinib, crizotinib, CP-724714, or afatinib for 12 hr, followed by stimulation with EGF, HGF, NRG1, or their combination (50 ng/ml) for 10 min.

    Nature, 2016, 534(7609):647-51. Afatinib (BIBW2992) purchased from Selleck.

    Cytoxicity of irreversible EGFR TKIS and ethacrynic acid on breast cells lines. A, Mean IC50 value of Afatinib.

    Oncotarget, 2016, 7(36):58038-58050. Afatinib (BIBW2992) purchased from Selleck.

  • Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

    Inhibition of anchorage-independent growth of lung tumor cell lines by selected inhibitors. Each selected cell line was treated with the indicated inhibitor at 0.1 μM and 1 μM concentrations for two weeks and cell colony size formation was scored under the Nikon inverted-phase microscope.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

  • After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of BIBW2992 for 3h,followed by 15-minute stimolation of 100ng/ml EGF

    Dr. Zhang of Tianjin Medical University. Afatinib (BIBW2992) purchased from Selleck.

製品安全説明書

EGFR阻害剤の選択性比較

生物活性

製品説明 Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively.
ターゲット
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
ErbB4 [2]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 1 nM 10 nM 14 nM
体外試験

BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrUWotFUUN3ME2wMlAxPTd{IN88US=> NU\oZWZjW0GQR1XS
KASUMI-1 MojnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY[4[mhwUUN3ME2wMlAxQTFzIN88US=> NVrhNGpUW0GQR1XS
HCC2218 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPNTWM2OD1yLkCwPVg4KM7:TR?= MoXSV2FPT0WU
KARPAS-45 MmewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrhO4Z[UUN3ME2wMlAyPjdzIN88US=> MWLTRW5ITVJ?
HSC-4 NXnYdZZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XTSWlEPTB;MD6wNVc1QCEQvF2= MU\TRW5ITVJ?
CHL-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2j2NGlEPTB;MD6wNVg{QSEQvF2= NFzKcG9USU6JRWK=
KY821 M4PXPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLHWmlKSzVyPUCuNFIxPiEQvF2= M3\o[XNCVkeHUh?=
NCI-N87 NXLpOVR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwMEK3O|Mh|ryP M4fPV3NCVkeHUh?=
DOK M1\Yb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYKyeWJ5UUN3ME2wMlA{OTl2IN88US=> MnXzV2FPT0WU
DSH1 M4r6RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfUTWM2OD1yLkCzN|E1KM7:TR?= NHTXbppUSU6JRWK=
MDA-MB-175-VII M{XJSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;2c2JKSzVyPUCuNFM1OTZizszN MoO1V2FPT0WU
NCI-H2170 M1LZd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIO1UmpKSzVyPUCuNFM4OjhizszN NUf5e29OW0GQR1XS
BT-474 NWPnNpd5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwMES5PFYh|ryP MVzTRW5ITVJ?
EFO-27 MkDjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mki3TWM2OD1yLkC1NVgzKM7:TR?= NUHDW3BtW0GQR1XS
NCI-H720 NEfs[npIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMEWzNlUh|ryP MkC4V2FPT0WU
PC-14 M1nxVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HUS2lEPTB;MD6wOVY3QCEQvF2= M3nwR3NCVkeHUh?=
EC-GI-10 M1LKTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnWS4VPUUN3ME2wMlA2QTF{IN88US=> MlPzV2FPT0WU
KYSE-450 NHfze|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwMEW5O|gh|ryP NUfPdJpYW0GQR1XS
BPH-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfaSZFiUUN3ME2wMlA2QTh6IN88US=> MnnVV2FPT0WU
NCI-H292 NISxSpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDOeYZLUUN3ME2wMlA3ODlizszN MmSwV2FPT0WU
H9 M4LKPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\pTWM2OD1yLkC3NVMzKM7:TR?= M1H2PHNCVkeHUh?=
NCI-H526 M4To[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTRZ|JKSzVyPUCuNFc5OjNizszN NE[3dmVUSU6JRWK=
NCI-H1623 NU[5cVg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoS5TWM2OD1yLkC4NFI2KM7:TR?= NGfVeJlUSU6JRWK=
KYSE-140 M{P6dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rGPWlEPTB;MD6wPFM{KM7:TR?= NU\ObJBEW0GQR1XS
Ca9-22 M1Xo[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPiU|gxUUN3ME2wMlA5OzV|IN88US=> NFO2OIhUSU6JRWK=
AU565 NHrZTGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7FTWM2OD1yLkC4OVA1KM7:TR?= NYfHTJZnW0GQR1XS
ZR-75-30 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HncGlEPTB;MD6wPVU1PSEQvF2= M{HyRnNCVkeHUh?=
NCI-H1770 NYr6TJY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwMUCyPEDPxE1? MV\TRW5ITVJ?
LB2241-RCC NUjCXWFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUSzZ|RzUUN3ME2wMlExQDh2IN88US=> MkPDV2FPT0WU
CAL-39 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnoRoVrUUN3ME2wMlEyPzl{IN88US=> M4\qZ3NCVkeHUh?=
UACC-893 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHoTWM2OD1yLkGxPFg2KM7:TR?= NETPdVNUSU6JRWK=
LU-65 M1\ZeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DCTmlEPTB;MD6xNlY{OyEQvF2= NVHVemtPW0GQR1XS
HN MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwMUOwO|ch|ryP MVvTRW5ITVJ?
TI-73 Ml;lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\1eYxKSzVyPUCuNVQ4OTVizszN MUfTRW5ITVJ?
KU812 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfReWpZUUN3ME2wMlE2PDV4IN88US=> M1XDeHNCVkeHUh?=
SW13 NVfqUYxiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HJdmlEPTB;MD6xOlIyPiEQvF2= NGHDUo5USU6JRWK=
BB30-HNC NXzqPXBtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTiTWM2OD1yLkG2OVc3KM7:TR?= NIDtSZZUSU6JRWK=
HSC-2 NG\LcI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYC0ZYM6UUN3ME2wMlE3QDN5IN88US=> NXT0VYF5W0GQR1XS
BV-173 Mn3MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTpTWM2OD1yLkG3OVk3KM7:TR?= Mnv6V2FPT0WU
CAL-27 M37oWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTBwMUe2N|Yh|ryP NIXVVnpUSU6JRWK=
SBC-1 NF;RdlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMUi5OVkh|ryP M4DFSnNCVkeHUh?=
CAL-33 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPVTWM2OD1yLkKwNVg1KM7:TR?= M{O2b3NCVkeHUh?=
NCI-H209 NX;ZWJZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLQTWM2OD1yLkKwOFYh|ryP Mn7XV2FPT0WU
COR-L105 NIjsT41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mln4TWM2OD1yLkKxNFg1KM7:TR?= M3L2dXNCVkeHUh?=
HSC-3 M1nUWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXPPI1UUUN3ME2wMlIyOTl6IN88US=> NG\OcnZUSU6JRWK=
NCI-H69 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fudGlEPTB;MD6yNVQ2OSEQvF2= MoDPV2FPT0WU
MOLT-13 MnvQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{T3VmlEPTB;MD6yN|k4PSEQvF2= MomzV2FPT0WU
ML-2 M4faUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwMkS4NFIh|ryP NFjGTXpUSU6JRWK=
IGROV-1 NYO1SVJmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnYOmw4UUN3ME2wMlI2QTV{IN88US=> M{G3R3NCVkeHUh?=
TK10 NVfPUIw4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXXXnFiUUN3ME2wMlI3PzN6IN88US=> NXW0UGhlW0GQR1XS
EoL-1-cell NUHYPVFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwMk[4PVIh|ryP NX\1RmNIW0GQR1XS
HO-1-N-1 NIXOOYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;IVWlEPTB;MD6yO|g2OyEQvF2= M2LtbnNCVkeHUh?=
BHY M1zzWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLoXYtUUUN3ME2wMlI5PjV3IN88US=> NF\vSplUSU6JRWK=
LU-139 M1q4dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7GfWQ1UUN3ME2wMlMxPTFizszN NGrOc2lUSU6JRWK=
23132-87 NH\yO2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLjRmZKSzVyPUCuN|E6OjNizszN M{fXT3NCVkeHUh?=
ACHN Mnm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nNNGlEPTB;MD6zNVk6PCEQvF2= MX\TRW5ITVJ?
DoTc2-4510 NGXMOHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfudGdKSzVyPUCuN|IzOTlizszN NXXNTmRpW0GQR1XS
BB65-RCC MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwM{S1PVMh|ryP M2f3XXNCVkeHUh?=
HLE MofNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfrTWM2OD1yLkO1NFQ3KM7:TR?= MV;TRW5ITVJ?
HCC1419 NVLZUnVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvhTWM2OD1yLkO2OFA5KM7:TR?= NYOzZ3pSW0GQR1XS
A388 NFW2SmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXf0PGgxUUN3ME2wMlM3QDV5IN88US=> MV;TRW5ITVJ?
NUGC-3 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwM{izO|Mh|ryP M{PUUXNCVkeHUh?=
KYSE-180 NF3n[IRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnj1TWM2OD1yLkO5NFg6KM7:TR?= M1jiV3NCVkeHUh?=
TE-6 NVH3S3ZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwNECyOFYh|ryP NGO2SWNUSU6JRWK=
A498 M{XjVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwNEC2O|Qh|ryP NXuwTW9KW0GQR1XS
NCI-H1648 Mn\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwNESxPFIh|ryP MU\TRW5ITVJ?
DU-145 M3u3[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXvcI5XUUN3ME2wMlQ1QDN|IN88US=> NFHscZpUSU6JRWK=
CW-2 MnPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU[4dol{UUN3ME2wMlQ3QTF2IN88US=> NFmxU|BUSU6JRWK=
A431 NGT6RodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zjdmlEPTB;MD60PFI{OyEQvF2= NYPHTHo3W0GQR1XS
SAS NFrESVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwNEizPVgh|ryP NHexVYNUSU6JRWK=
NCI-H2126 NYTBZ4RPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwNUG5NlYh|ryP NHHJWFVUSU6JRWK=
NCI-H358 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwNUOyNUDPxE1? M2HGVHNCVkeHUh?=
FADU NX7tNWhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfZZ3JKSzVyPUCuOVQ1ODRizszN MmfhV2FPT0WU
ACN M4fIRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3SwW2lEPTB;MD61OVA6PCEQvF2= MXzTRW5ITVJ?
HCC70 NXrpdlU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfzZ3NiUUN3ME2wMlU4PjZzIN88US=> M4nHOnNCVkeHUh?=
NCI-H1838 MmnyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVi5ZXE4UUN3ME2wMlYxOjl7IN88US=> NYL0d3p6W0GQR1XS
CAL-54 M1rLNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVy1fJBZUUN3ME2wMlYyPjJzIN88US=> M4TkXXNCVkeHUh?=
NCI-H1975 NWKyUJhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnid4NKSzVyPUCuOlE4OjhizszN Mk\VV2FPT0WU
COR-L88 Mnv5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjqPFBYUUN3ME2wMlY1OTF|IN88US=> M3q3dXNCVkeHUh?=
CTV-1 Mn72S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnxXYxKSzVyPUCuOlQ{QTJizszN NYH6T3ZCW0GQR1XS
EW-18 NF\TOZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwNki2PVgh|ryP M37ofHNCVkeHUh?=
HCC1806 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTtfoVTUUN3ME2wMlY6PjZ4IN88US=> M{G5eXNCVkeHUh?=
HuP-T4 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\rT2lEPTB;MD62PVc3KM7:TR?= Ml[zV2FPT0WU
MDA-MB-361 NVnF[IhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrO[lNrUUN3ME2wMlczPjZ{IN88US=> MmfrV2FPT0WU
NCI-H1573 NHe0XlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;t[GN[UUN3ME2wMlc{PjNizszN M{C1b3NCVkeHUh?=
KU-19-19 NWX1UnFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwN{e0OlQh|ryP NV;aeG9lW0GQR1XS
COLO-678 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TxemlEPTB;MD64NFg{PCEQvF2= MUXTRW5ITVJ?
C-33-A M2XMWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DHNmlEPTB;MD64NVI6PyEQvF2= MnyzV2FPT0WU
Calu-3 MkXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nzUmlEPTB;MD64NVQ{PCEQvF2= MWfTRW5ITVJ?
AGS Mm\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\xTWM2OD1yLkizOlQ5KM7:TR?= M2HzfnNCVkeHUh?=
SCC-25 MoPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33LfWlEPTB;MD64OFE4OSEQvF2= MWrTRW5ITVJ?
JVM-2 NWiybJBnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17wVGlEPTB;MD64PFI6QSEQvF2= MV3TRW5ITVJ?
HCE-T M3LiWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTKOYNmUUN3ME2wMlg5PDJ6IN88US=> NVz0U2V6W0GQR1XS
ES4 Mlf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLkTWM2OD1yLkm3PFM3KM7:TR?= MYLTRW5ITVJ?
EKVX NFrq[YdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfLT5FNUUN3ME2xMlAyODZ2IN88US=> NE\oOYJUSU6JRWK=
D-542MG M2\zRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTmbmFUUUN3ME2xMlAyODZ2IN88US=> NVPIeW8yW0GQR1XS
SW1116 NFGxTVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DwNWlEPTB;MT6wNVI5PyEQvF2= Mnf4V2FPT0WU
5637 Mm\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTKe5NoUUN3ME2xMlAyPTFizszN MVfTRW5ITVJ?
HT-1376 NUfQSm9OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTFwMEG1NVMh|ryP NU\2dGNTW0GQR1XS
NB69 NGPOb3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jOW2lEPTB;MT6wNlk1PSEQvF2= MknKV2FPT0WU
YKG-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4n0WmlEPTB;MT6wOVQyQSEQvF2= MknzV2FPT0WU
EW-3 MoDpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPDOlFKSzVyPUGuNFc5QDNizszN MV3TRW5ITVJ?
GCIY NF\aUGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTFwMEixNFQh|ryP M1j6RXNCVkeHUh?=
SK-MES-1 Mk\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlz1TWM2OD1zLkGxOFg4KM7:TR?= MY\TRW5ITVJ?
PANC-08-13 NUXMTHdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\sSIwyUUN3ME2xMlE3PDF4IN88US=> NVfCNYc3W0GQR1XS
SK-NEP-1 NH\kdZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvLTWM2OD1zLkG3OVE{KM7:TR?= Mnv1V2FPT0WU
SW954 MnrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHifnJjUUN3ME2xMlIxOjF2IN88US=> NH7UR4pUSU6JRWK=
NCI-SNU-5 NFjuRplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXL3VJI4UUN3ME2xMlI{QSEQvF2= NYnDdGF7W0GQR1XS
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SW900 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTdwOEKxNlEh|ryP MlK5V2FPT0WU
JVM-3 MoLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHT2V49KSzVyPUeuPFk2QTlizszN NWXZR4lIW0GQR1XS
OAW-28 NE\VVW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\q[4l7UUN3ME23Mlk1PTd6IN88US=> MW\TRW5ITVJ?
KURAMOCHI NXjvXphjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTdwOUS4NVEh|ryP MXPTRW5ITVJ?
BE-13 NHLnVnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3f3WWlEPTB;Nz65PFEyOiEQvF2= MlHCV2FPT0WU
VMRC-RCZ MmTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRThwMEG2PVch|ryP M2jzOnNCVkeHUh?=
NCI-H727 MoexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRThwMUC0NkDPxE1? NHXOcYdUSU6JRWK=
SW1710 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkSxTWM2OD16LkG4OVE2KM7:TR?= MmfjV2FPT0WU
D-502MG M4jQOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmf2TWM2OD16LkK5NlgzKM7:TR?= NGLrcolUSU6JRWK=
NCI-H1993 M{P2VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfNT2pVUUN3ME24MlM{PjNzIN88US=> MmfTV2FPT0WU
SCC-4 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHT3V2dKSzVyPUiuOFQxPTlizszN NFPpbJJUSU6JRWK=
HAL-01 MoThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\OTWM2OD16LkWxPVEh|ryP M{TTOHNCVkeHUh?=
GT3TKB M3rtcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PQfmlEPTB;OD62O|k3PCEQvF2= NWLNeVNsW0GQR1XS
SK-OV-3 NXv1dlhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfNUZpMUUN3ME24MlcyOzJ7IN88US=> M{OzUnNCVkeHUh?=
COLO-829 NU\CenJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1y3OGlEPTB;OD64NFk4PiEQvF2= NF7TflRUSU6JRWK=
OCI-AML2 NGDONXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jlVGlEPTB;OD65OVQ5OSEQvF2= MkXwV2FPT0WU
OS-RC-2 M{P1VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTlwMEKxPUDPxE1? NFfnbolUSU6JRWK=
BFTC-909 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPablZKSzVyPUmuNFY4QTlizszN MYTTRW5ITVJ?
EW-11 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTlwMUe2OVMh|ryP M2faUHNCVkeHUh?=
HCE-4 NYDHWIdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTlwMkG1OVgh|ryP NVXZNHRCW0GQR1XS
BALL-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPmUVFKSzVyPUmuNlE6ODdizszN MlW3V2FPT0WU
SF539 NFG5bFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfYTWM2OD17LkKzOVYzKM7:TR?= MkLOV2FPT0WU
CAMA-1 Mn\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnDWI9WUUN3ME25MlI5OTJ6IN88US=> NVjXSHFHW0GQR1XS
C32 NIe0Sm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfiTWM2OD17LkOzNFY1KM7:TR?= MUXTRW5ITVJ?
NCI-H1703 NInaWZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojkTWM2OD17LkO0N|c2KM7:TR?= NUTWUnBDW0GQR1XS
NCI-H1650 MknNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TVVmlEPTB;OT62NFk1PiEQvF2= NFr5eIRUSU6JRWK=
NCI-H1563 M1:1c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\IbZpKSzVyPUmuO|YxOzFizszN MUjTRW5ITVJ?
CAL-85-1 NW\tO5o{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTlwOEezPFMh|ryP M1f6RnNCVkeHUh?=
UM-UC-3 MmTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTlwOUWwN{DPxE1? M3THRXNCVkeHUh?=
BxPC-3 MljZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnHflZKSzVyPUGwMlA6PzJizszN NImxfIVUSU6JRWK=
MHH-PREB-1 NE\nWnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\Mb4NKSzVyPUGwMlE6QTlizszN M1jQXHNCVkeHUh?=
DEL NH6xWoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;3TWM2OD1zMD6zPVQ3KM7:TR?= M4nXXnNCVkeHUh?=
HuCCT1 MlnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7qTWM2OD1zMD62NFM{KM7:TR?= Mnz2V2FPT0WU
OVCAR-4 NEPv[ZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTXRXFUUUN3ME2xNE45QDN3IN88US=> M1\wN3NCVkeHUh?=
CAL-72 MoK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTFyLkmzPVEh|ryP NFX5NJhUSU6JRWK=
HCC1954 M2Xq[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTFzLkC3OVQh|ryP M{PNfXNCVkeHUh?=
EFO-21 M3f3WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHMUWNKSzVyPUGxMlExPDVizszN M{fLd3NCVkeHUh?=
FTC-133 MnLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LVeGlEPTB;MUGuNVQxPyEQvF2= MnrBV2FPT0WU
SK-MEL-24 M3jleWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXJTWM2OD1zMT6yN|Y3KM7:TR?= NX\MVHlMW0GQR1XS
UACC-62 NX\HWXJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXoRZpKSzVyPUGxMlI{PjhizszN MV3TRW5ITVJ?
NCI-H650 MnruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4ryfmlEPTB;MUGuNlQyQCEQvF2= NVvRfY9rW0GQR1XS
ALL-PO NVrMVVRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLJTWM2OD1zMT6yOVEzKM7:TR?= NV;TWFV7W0GQR1XS
T84 M{\aOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzSTWM2OD1zMT6zPVA4KM7:TR?= MkH5V2FPT0WU
IST-MEL1 M{\weWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17UUWlEPTB;MUGuOFU2QSEQvF2= NHLTbWpUSU6JRWK=
SW626 M2DXSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTFzLkW3OVUh|ryP NXm0e|RtW0GQR1XS
RPMI-2650 MlrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDzR|RKSzVyPUGxMlU5QDVizszN NYDNO|dXW0GQR1XS
MC-IXC M1LiPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXoZ5BKSzVyPUGxMlY4OjhizszN NWXOS3hXW0GQR1XS
HOP-62 NWO5So1XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HubmlEPTB;MUGuOlc3PCEQvF2= MXnTRW5ITVJ?
NOS-1 MlXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\xTWM2OD1zMT63NVA6KM7:TR?= NHrGfmxUSU6JRWK=
SW1573 NU\6dWxCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{izdWlEPTB;MUGuO|I6PSEQvF2= NHn2enRUSU6JRWK=
WM-115 MmHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTFzLke1PFgh|ryP MlLnV2FPT0WU
HuO9 MnnYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTFzLki3O|Qh|ryP MmDiV2FPT0WU
YAPC NXfKWZNYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXm5OppVUUN3ME2xNU46OjV7IN88US=> Mo[zV2FPT0WU
MDA-MB-453 NF7Eb2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jkemlEPTB;MUGuPVUyPSEQvF2= NWTiRot4W0GQR1XS
NCI-H596 NH:5WIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHvV|hKSzVyPUGyMlA{PjlizszN NHHBdWtUSU6JRWK=
A172 M4jtbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nFVGlEPTB;MUKuNFc6QCEQvF2= M17QV3NCVkeHUh?=
RS4-11 M2DXUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TJeWlEPTB;MUKuNVczPSEQvF2= MkHUV2FPT0WU
HCC1937 M2DOZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjxU3FMUUN3ME2xNk44PTZ2IN88US=> NGHJ[plUSU6JRWK=
SW837 NGXjbmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTF{LkmwNlgh|ryP M{TPWXNCVkeHUh?=
NMC-G1 M1rFN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn32TWM2OD1zMj65NlM1KM7:TR?= NX3xcZhOW0GQR1XS
PFSK-1 MkDCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETZcVlKSzVyPUGzMlA3KM7:TR?= Mlj2V2FPT0WU
DBTRG-05MG MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPmNZdXUUN3ME2xN{4xPjN{IN88US=> NHzjOGpUSU6JRWK=
SK-UT-1 NWC1WFM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\qRnJUUUN3ME2xN{4yODh|IN88US=> NGnwU3FUSU6JRWK=
OVCAR-5 NHHXdZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTF|LkG1PVMh|ryP Ml3EV2FPT0WU
8505C MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPIXVVrUUN3ME2xN{4zODZ5IN88US=> NVzuNYhrW0GQR1XS
SK-MEL-1 MoTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLGTWM2OD1zMz63NVM2KM7:TR?= M1rRZ3NCVkeHUh?=
LK-2 M17ne2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXOXmdjUUN3ME2xN{44PjN7IN88US=> MoX0V2FPT0WU
OE33 NXrBUWZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXBTXpKSzVyPUGzMlc5PiEQvF2= M{X4OHNCVkeHUh?=
Ramos-2G6-4C10 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTF2LkCyNFIh|ryP MnrmV2FPT0WU
EW-13 M1XIdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTF2LkCzOVIh|ryP MYjTRW5ITVJ?
NCI-H1793 M2XCS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHPTWM2OD1zND6yNFg4KM7:TR?= MoPTV2FPT0WU
BHT-101 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPQTWM2OD1zND6yOFEh|ryP MUjTRW5ITVJ?
RKO MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn:1TWM2OD1zND61NFc2KM7:TR?= NHLrVVVUSU6JRWK=
NEC8 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTaTWM2OD1zND61OFczKM7:TR?= MWXTRW5ITVJ?
PANC-10-05 NYPqZ21iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2S2UWlEPTB;MUSuOlI1PyEQvF2= MmfQV2FPT0WU
NCI-H2030 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3yTWM2OD1zND62OFQ5KM7:TR?= MnrTV2FPT0WU
C2BBe1 NYm2[Yl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml:2TWM2OD1zND63OlQh|ryP MULTRW5ITVJ?
EM-2 NI\re|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnZdphKSzVyPUG0Mlg2PzZizszN NEDHR49USU6JRWK=
HCC1395 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnT4TWM2OD1zND65N|M5KM7:TR?= MUTTRW5ITVJ?
A2058 M2nD[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTF3LkC0NFkh|ryP MUnTRW5ITVJ?
SW1463 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTF3LkC0PFUh|ryP Ml;WV2FPT0WU
J82 NXXid41uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmD6TWM2OD1zNT6wOVch|ryP MVLTRW5ITVJ?
CAL-120 M{H4Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jZ[WlEPTB;MUWuNVQ1PyEQvF2= NXW3fZd7W0GQR1XS
COLO-824 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vpR2lEPTB;MUWuNVU4QSEQvF2= NUfiTlBGW0GQR1XS
LNCaP-Clone-FGC NEHqUphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXKUlJKSzVyPUG1MlQzPDhizszN M13X[3NCVkeHUh?=
CP66-MEL MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvmXVFjUUN3ME2xOU41Pjh6IN88US=> NX7LSno2W0GQR1XS
OC-314 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojWTWM2OD1zNT60O|E1KM7:TR?= MoHwV2FPT0WU
OVCAR-8 NWfaRZY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnKPYJKSzVyPUG1Mlg5PjFizszN NFjhZpdUSU6JRWK=
MFE-280 NGPUbZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTF4LkC0PFgh|ryP MVHTRW5ITVJ?
MHH-NB-11 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlS1TWM2OD1zNj6wPFM6KM7:TR?= Mo\qV2FPT0WU
SW1990 NGD1fIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzNTWM2OD1zNj6xO|U2KM7:TR?= NX72eY5WW0GQR1XS
U-266 MnrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTF4LkKyPVkh|ryP MkO1V2FPT0WU
MFM-223 MoC5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGH4ZnJKSzVyPUG2MlM6PjVizszN MnW3V2FPT0WU
L-363 M3TKVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTF4LkS1O|ch|ryP M2LqWnNCVkeHUh?=
MCF7 NFzafpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHH3VXdKSzVyPUG2MlQ4OjNizszN NIHHbm9USU6JRWK=
SK-MEL-3 NIfIXYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTlZ4dKSzVyPUG2MlQ4QDdizszN MYDTRW5ITVJ?
HH NHXNNmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17SVGlEPTB;MU[uOVE3OiEQvF2= NEjkRYdUSU6JRWK=
no-10 MnLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTF4Lk[zOFMh|ryP NVnER3hGW0GQR1XS
HuP-T3 NYPu[lg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;FdJRPUUN3ME2xOk43PTd4IN88US=> NFvGRYlUSU6JRWK=
QIMR-WIL MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NED4XZdKSzVyPUG2MlcyODVizszN M4nFUnNCVkeHUh?=
NCI-H1092 NHHJbGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnn3TWM2OD1zNj64N|E3KM7:TR?= NWLwTHZKW0GQR1XS
MZ2-MEL NUDtS3hkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3LcFVKSzVyPUG2Mlg1ODNizszN NGG3ZppUSU6JRWK=
ES3 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHObIRzUUN3ME2xOk46OTN2IN88US=> MX\TRW5ITVJ?
COLO-684 M1PiUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjmZldYUUN3ME2xOk46PDd5IN88US=> MV;TRW5ITVJ?
NCI-H661 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;4PWlEPTB;MU[uPVY6PCEQvF2= M3\Fd3NCVkeHUh?=
CP50-MEL-B MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;jb4lxUUN3ME2xO{4xOzR|IN88US=> NEDSPYtUSU6JRWK=
NCI-H2405 M4\LV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXywfYFpUUN3ME2xO{4yQTd2IN88US=> MX;TRW5ITVJ?
U-2-OS MnnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXlZ2NKSzVyPUG3MlU{ODdizszN MmTHV2FPT0WU
RERF-LC-MS M4j6Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7kTWM2OD1zNz61OVA5KM7:TR?= NFXWZmVUSU6JRWK=
NCI-H2342 NXXnU4g4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\UTWM2OD1zNz61OVch|ryP NHjKOINUSU6JRWK=
ES8 MoK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDKNVNJUUN3ME2xO{43ODh5IN88US=> M2HLbXNCVkeHUh?=
MOLT-16 Mo[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3z3O2lEPTB;MUeuPFk{PCEQvF2= NFOwbI5USU6JRWK=
RH-18 NFTqUHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX:wTHZkUUN3ME2xPE4xODN3IN88US=> NYHjPWRZW0GQR1XS
D-283MED NYLEXXROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljpTWM2OD1zOD6wNFg5KM7:TR?= NX65fI1uW0GQR1XS
RCC10RGB NEG5bIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTF6LkC1OVkh|ryP M{PkOXNCVkeHUh?=
NCI-H1437 MmThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLBTWM2OD1zOD6xOlQyKM7:TR?= MlW1V2FPT0WU
SW982 MmniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHNSVNKSzVyPUG4MlI3PzFizszN Mn3LV2FPT0WU
IST-MES1 MnnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnWcXZ4UUN3ME2xPE41PDJ6IN88US=> NVn6e2VZW0GQR1XS
A704 MnOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PHbGlEPTB;MUiuOFc2OyEQvF2= MoL4V2FPT0WU
ESS-1 NFHuU29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTF6LkWyNFUh|ryP MlfqV2FPT0WU
SCH M2DVdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTF6Lk[0OVYh|ryP MnfWV2FPT0WU
COLO-320-HSR NHy3WZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlm4TWM2OD1zOD63OFYh|ryP Mn\IV2FPT0WU
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KP-N-YS NXLIXVNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkmyTWM2OD12MD62O|Y5KM7:TR?= MWDTRW5ITVJ?
DMS-114 Ml3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnuTWM2OD12MD64N|c1KM7:TR?= NUHuUZhuW0GQR1XS
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HPAF-II MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jpemlEPTB;NEGuOlcxQSEQvF2= MWDTRW5ITVJ?
UACC-257 M1qxWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLiboRKSzVyPUSxMlc{PjlizszN MV3TRW5ITVJ?
EW-22 M4[yc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPJTWM2OD12MT64Olk4KM7:TR?= NUX6b5lCW0GQR1XS
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NB13 NV;6Z44{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFGySGRKSzVyPUSyMlYzOTdizszN MVfTRW5ITVJ?
SW872 NYHE[YlIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTR{Lk[zN|Eh|ryP MnL2V2FPT0WU
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M14 NIS3ZVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjPOnNKSzVyPUS0MlE{OzJizszN NI\rboJUSU6JRWK=
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NCI-H460 MoDCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTR4LkWyN{DPxE1? M2XUcHNCVkeHUh?=
CAS-1 NWnl[pJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfJTWM2OD12Nj63O|AyKM7:TR?= MmXFV2FPT0WU
TGBC11TKB MnHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vqVWlEPTB;NEeuNVc4PyEQvF2= MWTTRW5ITVJ?
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NCI-H226 NG\HUWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;2TWM2OD12OT63O|g2KM7:TR?= MVjTRW5ITVJ?
PA-1 M3jqR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TjeGlEPTB;NEmuPFM{PSEQvF2= MYDTRW5ITVJ?
LB2518-MEL MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjTW|NKSzVyPUS5Mlg4OjNizszN M3mweXNCVkeHUh?=
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NCI-H2087 M{jKWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3tcGhVUUN3ME20PU46Pjh{IN88US=> NFnkNolUSU6JRWK=

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

体内試験 Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]

お薦めの試験操作(参考用のみ)

キナーゼ試験:

[1]

+ 展開

In vitro kinase activity assays:

The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.
細胞試験:

[1]

+ 展開
  • 細胞株: NSCLC cells
  • 濃度: 0-10 μM
  • 反応時間: 1 hour
  • 実験の流れ:

    1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.


    (参考用のみ)
動物試験:

[1]

+ 展開
  • 動物モデル: Athymic NMRI-nu/nu female mice
  • 製剤: In 0.5% methocellulose-0.4% polysorbate-80 (Tween 80)
  • 投薬量: 20 mg/kg
  • 投与方法: Oral administration
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
混合させたのち直ちに使用することを推奨します。
10mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 485.94
化学式

C24H25ClFN5O3

CAS No. 439081-18-2
保管
in solvent
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03727724 Not yet recruiting Carcinoma Non-Small-Cell Lung The Netherlands Cancer Institute|Boehringer Ingelheim|Merck Serono International SA November 2018 Phase 2
NCT03695510 Not yet recruiting Head and Neck Neoplasms National Taiwan University Hospital November 2018 Phase 2
NCT03652233 Not yet recruiting Recurrent Squamous Cell Carcinoma of the Head or Neck|Platinum- and Cetuximab-Refractory Squamous Cell Carcinoma of the Head or Neck|Metastatic Squamous Cell Carcinoma of the Head or Neck|Squamous Cell Carcinoma Vanderbilt-Ingram Cancer Center|National Comprehensive Cancer Network|Boehringer Ingelheim November 2018 Phase 1
NCT03711422 Not yet recruiting Non-small Cell Lung Cancer|Leptomeningeal Disease|Central Nervous System Metastases National Cancer Centre Singapore October 2018 Phase 1
NCT03574402 Not yet recruiting Carcinoma Non-Small-Cell Lung Guangdong Association of Clinical Trials July 1 2018 Phase 2
NCT03083678 Recruiting Chordoma Leiden University Medical Center|Chordoma Foundation|Boehringer Ingelheim June 21 2018 Phase 2

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答:

    For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

EGFRシグナル伝達経路

EGFR Inhibitors with Unique Features

相関EGFR製品

Tags: Afatinib (BIBW2992)を買う | Afatinib (BIBW2992) ic50 | Afatinib (BIBW2992)供給者 | Afatinib (BIBW2992)を購入する | Afatinib (BIBW2992)費用 | Afatinib (BIBW2992)生産者 | オーダーAfatinib (BIBW2992) | Afatinib (BIBW2992)化学構造 | Afatinib (BIBW2992)分子量 | Afatinib (BIBW2992)代理店
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