Genistein

For research use only. Not for use in humans.

製品コードS1342

Genistein化学構造

分子量(MW):270.24

Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM.

サイズ 価格(税別) 在庫  
10mM (1mL in DMSO) JPY 16900 あり
JPY 13600 あり
JPY 20200 あり
JPY 30200 あり
最寄りの販売代理店を探す

お探しのディーラーが見当たらない場合は直接こちらのメールアドレスまでお問い合わせください:[email protected]

バルク問合せ

文献中Selleckの製品使用例(7)

製品安全説明書

EGFR阻害剤の選択性比較

生物活性

製品説明 Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM.
ターゲット
EGFR [1] topo II [1]
体外試験

Genistein is an ATP competitive inhibitor. Genistein inhibits tyrosine phosphorylation in isolated enzyme and receptor preparations and in whole cells including platelets, lymphocytes and a variety of cultured cells. It also inhibits EGF-stimulated phosphorylation in cultured cells as well as inhibition of Topo II (topoisomerase II). Genistein inhibits EGF-stimulated tyrosine phosphorylation in cultured A431 epidermoid carcinoma cells. Inhibition is competitive with ATP and noncompetitive with substrate. [1] Genistein blocks the mitogenic effect mediated by EGF, insulin and thrombin on NIH-3T3 cells.[2] Genistein also acts as an agonist at the GPR30 receptor and binds to PPARγ and estrogen receptors. Genistein also binds to PPARγ, acting as an agonist at this receptor with Ki of 5.7 μM. [3]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
293T cells NG\0Z2RHfW6ldHnvckBie3OjeR?= MYrEbZNxdGGlZX3lcpQhd2ZiW{PIYVE4[mW2YT3ld5Rz[WSrb3yg[pJwdSC{ZXPvcYJqdmGwdDDoeY1idiCHUnLleIEh\XiycnXzd4VlKGmwIEK5N3Qh[2WubIOsJGlEPTB;MD6wNFE{KM7:TR?= M1LIU|E3OjF7NE[z
HeLa cells NV\MV3FDTnWwY4Tpc44h[XO|YYm= MYTBZ5RqfmG2aX;uJI9nKGW|dILv[4VvKHKnc4DvcpNmKGWuZX3lcpQhcW5iSHXMZUBk\WyuczDzeIFjdHlidILhcpNn\WO2ZXSge4l1cCCqdX3hckBGe3S{b3flckBz\WOncITvdkBj\XSjLDDFR|UxRTBwMEC0NUDPxE1? NUXyc3ZOOTF7ME[yPFA>
human Ishikawa cells MkjXSpVv[3Srb36gZZN{[Xl? MmTFOEBl[Xm| MVnFd5Rzd2enbnnjJIFkfGm4aYT5JIlvKGi3bXHuJGl{cGmtYYfhJINmdGy|IHHzd4V{e2WmIHHzJIlv\HWldHnvckBw\iCjbHvhcIlv\SCyaH;zdIhifGG|ZTDhZ5Rqfmm2eTDh[pRmeiB2IHThfZMh[nlicHHyZU1vcXS{b4Do[Y5wdCC{ZXzlZZNmKGG|c3H5MEBKSzVyPUCuOVEh|ryP NIr4c5AyOjVyMkOwOy=>
human MCF7 cells MWnDfZRwfG:6aXRCpIF{e2G7 MXO0PEBp NXHMVoFuS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVEh|ryP M2rVZ|IxQDF|NUK0
NIH3T3 cells MXXGeY5kfGmxbjDhd5NigQ>? NVz1WZNzSWexbnnzeEBi[3Srdnn0fUBifCCFRmTSMYRmdHSjRkWwPEBufXSjboSg[ZhxemW|c3XkJIlvKE6LSEPUN{Bk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCob4Lzb49tcW5vc4TpcZVt[XSnZDDjeZJz\W62LDDFR|UxRTRwNDFOwG0> NFe1XFYyQDV7NU[5Oi=>
human HL60 cells MmfSSpVv[3Srb36gZZN{[Xl? M1f0NlI1KGh? NV\KcW97SW62aXzleYtmdWmlIHHjeIl3cXS7IHHnZYlve3RiaIXtZY4hUEx4MDDj[YxteyCjZoTldkAzPCCqcoOgZpkh[2yxbn;n[Y5q[yCjc4PhfUwhVEN3ME22MlMh|ryP NX[4c3h1OThzNkO1PFk>
mouse L1210 cells NFP1UlBHfW6ldHnvckBie3OjeR?= NFLiem8zPCCq NXzpUGl3SW62aXzleYtmdWmlIHHjeIl3cXS7IHHnZYlve3RibX;1d4UhVDF{MUCgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KGOub37v[4VvcWNiYYPzZZktKEyFNUC9Ok42KM7:TR?= MX[xPFE3OzV6OR?=
MDCK cells  NV6xWlNDTnWwY4Tpc44h[XO|YYm= MkOxTY5pcWKrdHnvckBw\iCEQ2LQJIV5eHKnc4Pl[EBqdiCPRFPLJINmdGy|IIXzbY5oKEixZXPod5QhOzN|NEKgd5RicW6rbnesJGlEPTB;Nj65JO69VQ>? M3S3UVIyOzV2OECw
human MOLT3 cells MoPDSpVv[3Srb36gZZN{[Xl? NYGxNmRLOjRiaB?= NF;3b|FCdnSrbHX1b4VucWNiYXP0bZZqfHliYXfhbY5{fCCqdX3hckBOV0yWMzDj[YxteyCjZoTldkAzPCCqcoOgZpkh[2yxbn;n[Y5q[yCjc4PhfUwhVEN3ME23MlUh|ryP MkD0NVgyPjN3OEm=
ANN-1 cells M2Xyd2N6fG:2b4jpZ:Kh[XO|YYm= MUTDfZRwfG:6aXOg[YZn\WO2IH;uJJYu[WKuIITyZY5{\m:{bXXkJI12emmwZTDBUm4uOSClZXzsd{whUUN3ME24JO69VQ>? MYO4NlAyPjB|
human MCF7 cells NXLObW56WHKxbHnm[ZJifGmxbjDhd5NigQ>? M2e3[WFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4Sg[ZN1em:pZX6gdoVk\XC2b4Kg[ZhxemW|c3nu[{BpfW2jbjDNR2Y4KGOnbHzzMEBIUTVyPUGwJO69VQ>? MVixPVgyQDZzMh?=
human Raji cells NYexfFJmTnWwY4Tpc44h[XO|YYm= MWSyOEBp MXXBcpRqdGW3a3XtbYMh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDSZYpqKGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDjcI9vd2enbnnjJIF{e2G7LDDMR|UxRTF|Lkeg{txO MXuxPFE3OzV6OR?=
human LoVo cells Mny5R5l1d3SxeHnjxsBie3OjeR?= NHfXeXk4OiCq NEXUOYhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNd1[xIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NVUvQDhizszN NEjnWIIzOTF{OUm3Oy=>
K562 cells NVrPXVlFT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MniwOUBl[Xm| MU\Hdo94fGhiaX7obYJqfGmxbjDv[kBMPTZ{IHPlcIx{KGK7IGjUWEBie3OjeTDh[pRmeiB3IHThfZMtKEmFNUC9NVcvPTZizszN MXexO|QyOTB7Mh?=
RAW 264 cells NU\qfnA2TnWwY4Tpc44h[XO|YYm= NH[yVVAzPCCq MVPJcohq[mm2aX;uJI9nKDFidXevcYwhVFCVLYP0bY12dGG2ZXSgWG5H[WyyaHGgZYNkfW23bHH0bY9vKGmwIGLBW{AzPjRiY3XscJMh[W[2ZYKgNlQhcHK|LDDJR|UxRTF6LkGg{txO M1TxR|E4OzJyMkS2
mouse RAW264.7 cells MmXsSpVv[3Srb36gZZN{[Xl? MoPpNlQhcA>? MY\BcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJI1wfXOnIGLBW|I3PC55IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhVFCVLXnu[JVk\WRiVF7GZYxxcGFicILv[JVkfGmxbjD0doVifGWmIEKgbJJ{KGKnZn;y[UBNWFNiY3jhcIxmdmenIH3lZZN2emWmIHHmeIVzKDJ2IHjyd{BjgSCHTFnTRUwhUUN3ME2xPU4yKM7:TR?= M{e0W|IyOjh6N{K3
HEK293 cells NEDze|ZHfW6ldHnvckBie3OjeR?= NWfv[Y1qSW62YXfvcol{fCCjY4Tpeol1gSCjdDDoeY1idiC{ZXPvcYJqdmGwdDDMXHJj\XSjIHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCLQ{WwQVIzKM7:TR?= MUGxPFM1OzF{Nh?=
3T3 cells M4HScGN6fG:2b4jpZ:Kh[XO|YYm= NGXtW29EgXSxdH;4bYMh\W[oZXP0JI9vKDOWMzDj[YxteyxiSVO1NF0zPCEQvF2= NWnHfFN1QDJyMU[wNy=>
human MCF7 cells M36ySWZ2dmO2aX;uJIF{e2G7 M4PseVYhcA>? MUDJcohq[mm2aX;uJI9nKHCqb4Lic4wh\XO2ZYKtbY5lfWOnZDDvdo5qfGirbnWg[IVk[XKkb4j5cIF{\SCrbjDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDZiaILzMEBKSzVyPUK2JO69VQ>? NY\zVnNDOTByN{W3OFI>
WiDr human colon cells NIPG[ndEgXSxdH;4bYPDqGG|c3H5 NYjUNJV5S3m2b4TvfIlkKGWoZnXjeEBwdiCZaVTyJIh2dWGwIHPvcI9vKGOnbHzzMEBKSzVyPUK3Mlch|ryP M1nMOVgzODF4MEO=
NHEM cells MkGxSpVv[3Srb36gZZN{[Xl? MWS3NkBp NXHkRZFwUW6qaXLpeIlwdiCxZjDt[YxidmmwIIP5cpRp\XOrczDpckBPUEWPIHPlcIx{KGG|c3Xzd4VlKGG|IGuxOGNefGirb4XyZYNqdCCrbnPvdpBwemG2aX;uJIFnfGW{IEeyJIhzeyCkeTDsbZF2cWRic3PpcpRqdGyjdHnvckBkd3WwdHnu[{whUUN3ME2yPU4zKM7:TR?= NEPadmQyQTF|MkmzOC=>
human BxPC3 cell NFnqO5JRem:uaX\ldoF1cW:wIHHzd4F6 MWnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEK6UFOzJINmdGxibHnu[UBjgSCPVGSgZZN{[XluIFnDOVA:OzBizszN MUOxOlc5QTd|Nx?=
human LNCAP cells NFnVPHREgXSxdH;4bYPDqGG|c3H5 MXe3NkBp NFTaW4JEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNVkODUDDj[YxteyCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVMxNjZ3IN88US=> M3Tm[|IyOTJ7OUe3
HEK293 cells MmK2SpVv[3Srb36gZZN{[Xl? M4rE[GFvfGGpb37pd5Qh[WO2aY\peJkh[XRiaIXtZY4hemWlb33ibY5idnRiTGjSZYxxcGFiZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEmFNUC9N|Eh|ryP NULpOXJkOTh|NEOxNlY>
human HCT116 cells NG[2THREgXSxdH;4bYPDqGG|c3H5 NUfKbGZCPzJiaB?= M4jueGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVM1NjlizszN MY[yNVEzQTl5Nx?=
human AGS cells NVLOWWVbS3m2b4TvfIlkyqCjc4PhfS=> NWT5W3M4PzJiaB?= MUTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBS3Mh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD12MT62O{DPxE1? MoDJNlEyOjl7N{e=
human PC3 cells M{\RSHBzd2yrZnXyZZRqd25iYYPzZZk> MUC0PEBp M4\VfGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgZY5lem:pZX6gdoVk\XC2b4Kt[IVncWOrZX70JIh2dWGwIGDDN{Bk\WyuczDpcoN2[mG2ZXSge4l1cCByLk[gcm0hd2ZiZYP0doFlcW:uIHHu[EAxNjdibl2gc4YhfGW|dH;zeIVzd26nIHHmeIVzKDR6IHjyd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGG|c3H5MEBIUTVyPUSyMlY2QCEQvF2= M2Pz[FIyPTF|Mke1
human A549 cells NELMdHdEgXSxdH;4bYPDqGG|c3H5 NWPu[3hiPzJiaB?= NGDLdYdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFczKGi{czDifUBUWkJiYYPzZZktKEmFNUC9OFMvODlizszN MWCyNVEzQTl5Nx?=
human BT20 cell NGm4fGlRem:uaX\ldoF1cW:wIHHzd4F6 NUnhd5NFSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDCWFIxKGOnbHygcIlv\SCkeTDNWHQh[XO|YYmsJGlEPTB;NE[g{txO NIe2fIQyPjd6OUezOy=>
human DU145 cells MYjDfZRwfG:6aXRCpIF{e2G7 MmLqO|IhcA>? M{TDUWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGRWOTR3IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9OFcvOjlizszN NWrlcVVDOjFzMkm5O|c>
human U937 cells M333V3Bzd2yrZnXyZZRqd25iYYPzZZk> NWHTNXhDPzJiaB?= MYHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFV7M{egZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KFeVVD24JIF{e2G7LDDJR|UxRTR6IN88US=> NVPFRYNKOTdzNUiwOVQ>
human MOLT3 cells NU\CZ3RZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4Tx[lQ5KGh? MUfHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDNU2xVOyClZXzsd{Bi\nSncjC0PEBpenN? MkKwNVgyPjN3OEm=
human T47D cells MkHhSpVv[3Srb36gZZN{[Xl? NFzCOZJGe3S{b3flcolkKGGldHn2bZR6KGmwIHj1cYFvKFR2N1SgZ4VtdHNiYYPz[ZN{\WRiYYOg[JJ2\yCuZY\lcEBk[XW|aX7nJJN1cW23bHH0bY9vKG:oIHPlcIwheHKxbHnm[ZJifGmxbjDldZVqfmGuZX70JJRwKDFyIIDNJIV{fHKjZHnvcEBjgSCjbHHtZZIh[my3ZTDhd5NigQ>? M{jmUVE2Pzh5NEO2
human MDA-kb2 cells MXTGeY5kfGmxbjDhd5NigQ>? NUewOWY2SWexbnnzeEBi[3Srdnn0fUBifCCjbnTyc4dmdiC{ZXPldJRweiCrbjDoeY1idiCPRFGtb4IzKGOnbHzzJIF{e2W|c3XkJIF{KHO2aX31cIF1cW:wIH;mJIx2[2moZYLhd4Uh[WO2aY\peJkh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5 NYP6RmJFOTl3OUKyOFU>
human MCF7 cells NIHHW2dHfW6ldHnvckBie3OjeR?= MYWwMlEuOjBizszN NXW1U5FYPCCmYYnz MYnTeIlufWyjdHnvckBw\iCpcn;3eIghcW5iaIXtZY4hVUOINzDj[YxteyCjdDCwMlEhfG9iMkCgeW0h[W[2ZYKgOEBl[Xm|IHL5JG1VXCCjc4PhfS=> MW[yOVA4QDNzNB?=
HUVE12 cells M3vr[WZ2dmO2aX;uJIF{e2G7 NHT6d41T\X[ncoPhcEBw\iCqeXTyc4dmdiCyZYLvfIll\S2rbnT1Z4VlKEyGSDDhZ5Rqfmm2eTDpckBpfW2jbjDIWXZGOTJiY3XscJM> MnnINVgxPjh7OEC=
human MCF7 cells NV:1WZVPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MV2yNE0yODBizszN NHnVNXY1KGSjeYO= NXvsNndpT3Kxd4ToJIlvcGmkaYTpc44hcW5iaIXtZY4hVUOINzDj[YxteyCjdDCyNEB1dyBzMECgeW0h[W[2ZYKgOEBl[Xm|IHL5JG1VXCCjc4PhfS=> M175NVI2ODd6M{G0
A431 cells M1HYTGZ2dmO2aX;uJIF{e2G7 NX3Id2o6PTBidH:gO|UhfU1? NWXYWGl4OzZiaB?= MorXR4VtdCCleXPs[UBienKnc4SgbY4hcHWvYX6gRVQ{OSClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDhZ4N2dXWuYYTpc44h[XRiR{CvS|EheGijc3WgZZQhPTBidH:gO|UhfU1iYX\0[ZIhOzZiaILzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUhe3SjaX7pcocu[mG|ZXSg[oxwfyCleYTvcYV1emmlIHHuZYx6e2m| NFvoV4ozPDR3NkCwOC=>
human SKBR3 cells NIrGSZZHfW6ldHnvckBie3OjeR?= MV61NEB1dyB5NTD1US=> MmryN|YhcA>? NUXXN5pzS2WubDDjfYNt\SCjcoLld5QhcW5iaIXtZY4hW0uEUkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[WOldX31cIF1cW:wIHH0JGcxN0dzIIDoZZNmKGG2IEWwJJRwKDd3IIXNJIFnfGW{IEO2JIhzeyCkeTDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pLXLhd4VlKG[ub4egZ5l1d22ndILpZ{BidmGueYPpdy=> MXeyOFQ2PjByNB?=

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

アッセイ
Methods Test Index PMID
Western blot
PPARγ / C/EBPα / αP2 ; 

PubMed: 18384126     


Genistein dose-dependently inhibits adipogenic gene expression. Mouse BMSC cultures were exposed to adipogenic cocktail in the presence of increasing concentrations of genistein. Cells were harvested at day 21, and whole cell proteins were subjected to western blotting analysis. 

p-ERK; 

PubMed: 18384126     


Genistein dose-dependently inhibits the phosphorylation of ERK1/2. Cells were treated as above and harvested at day 5 after 5 min exposure to adipogenic cocktail, and whole cell protein were subjected to western blotting analysis.

Foxo3; 

PubMed: 21639915     


Genistein inhibits EGF-induced translocation of FOXO3. Immunofluorescent staining of experimental monolayers revealed that EGF-induced FOXO3 translocation from the nucleus to the cytosol was inhibited by genistein. This experiment was repeated two times in triplicate.

CIP2A / PARP / Cleaved PARP / Caspase-3 / Cleaved Caspase-3 ; 

PubMed: 27574003     


MCF-7, MCF-7-C3 and T47D cells were treated with genistein (GENI) at indicated concentrations for 48 h. Protein levels of CIP2A and PARP in all three cell lines, and caspase-3, cleaved caspase-3 (C-caspase-3) in MCF-7-C3 and T47D cells were detected with western blot analysis.

p-AKT / AKT ; 

PubMed: 27574003     


Genistein inhibits Akt phosphorylation. MCF-7-C3 and T47D cells were treated with genistein at indicated concentrations for 16 h. Phospho-Akt and Akt were detected with western blotting. *P<0.05.

DNMT-1 / DNMT-3a / DNMT-3b ; 

PubMed: 25931004     


Western blot analysis of the effect of physiological concentrations of genistein (0.5–10 µmol/L) on protein expression of the three DNMT subtypes, DNMT1, DNMT3a and DNMT3b in PCa cells.

18384126 21639915 27574003 25931004
Immunofluorescence
ER-β / pS87 ER-β ; 

PubMed: 25931004     


Cells were treated with DMSO (vehicle) or genistein 1 µmol/L and 10 µmol/L for 4hr. Then, cells were fixed, immunostained with pan ER-β and pS87 antibodies simultaneously and visualized by the confocal microscope. The red fluorescent staining in the first column is for pan ER-β, the green fluorescent staining in the second column is for pS87 and the third column is for both images merged together using image J software.

25931004
体内試験 Genistein has chemopreventive effects on breast, prostate, and other endocrine-dependent tumors in adult animals. Genistein in the diet reduced the incidence of poorly differentiated prostatic adenocarcinomas in a dose-dependent manner and down-regulated androgen receptor, estrogen receptor-alpha, progesterone receptor, epidermal growth factor receptor, insulin-like growth factor-I, and extracellular signal-regulated kinase-1 but not estrogen receptor-beta and transforming growth factor-alpha mRNA expressions. Dietary genistein protects against mammary and prostate cancers by regulating specific sex steroid receptors and growth factor signaling pathways.[4] Genistein combined with prostate tumor irradiation causes greater inhibition of primary tumor growth and increases control of spontaneous metastasis to para-aortic lymph nodes, increasing mouse survival. Paradoxically, treatment with genistein alone increases metastasis to lymph nodes. [5]

お薦めの試験操作(参考用のみ)

溶解度 (25°C)

体外 DMSO 54 mg/mL (199.82 mM)
Ethanol 2 mg/mL (7.4 mM)
Water Insoluble

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 270.24
化学式

C15H10O5

CAS No. 446-72-0
保管
in solvent
別名 N/A
Smiles OC1=CC=C(C=C1)C2=COC3=C(C(=CC(=C3)O)O)C2=O

投与溶媒組成計算器(クリア溶液)

ステップ1:実験データを入力してください。(余分な消耗を考慮し動物一匹分の量を用意することをお勧めします。)
投与量 mg/kg 動物平均体重 g 投与体積(動物毎) ul 動物数
ステップ2:投与溶媒の組成を入力してください。(ロットごとに組成が異なるため、セレックから完全に溶解できる組成をお求めください。)
% DMSO % % Tween 80 % ddH2O
計算リセット

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (mg) = 濃度 (mM) x 体積 (mL) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01982578 Recruiting Dietary Supplement: Genistein|Other: Placebo Alzheimer''s Disease Fundación para la Investigación del Hospital Clínico de Valencia|University of Valencia September 1 2017 Not Applicable
NCT02499861 Completed Drug: Decitabine and Genistein Cancer St. Justine''s Hospital July 2015 Phase 1|Phase 2
NCT01628471 Completed Drug: decitabine in combination with genistein Non Small Cell Lung Cancer Uman Pharma|DSM Nutritional Products Inc.|MDEIE Ministry Québec Government|INRS-Institut Armand Frappier Université du Québec November 2012 Phase 1|Phase 2

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

EGFRシグナル伝達経路

相関EGFR製品

Tags: Genisteinを買う | Genistein ic50 | Genistein供給者 | Genisteinを購入する | Genistein費用 | Genistein生産者 | オーダーGenistein | Genistein化学構造 | Genistein分子量 | Genistein代理店
×
細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID