Gefitinib (ZD1839)

製品コードS1025

Gefitinib (ZD1839)化学構造

分子量(MW):446.90

Gefitinib (ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.

サイズ 価格(税別)  
JPY 31706.00
JPY 24402.00
JPY 44820.00

文献中Selleckの製品使用例(93)

カスタマーフィードバック(14)

  • c, HCC4006 lung cancer cells that have acquired a high-mesenchymal state concomitant with becoming resistant to gefitinib (red curve) exhibit increased sensitivity to GPX4 inhibition.

    Nature, 2017, 547(7664):453-457. Gefitinib (ZD1839) purchased from Selleck.

    Perturbation of EGFR by its ligand EGF and gefitinib (ZD-1839 Iressat; inhibits EGFR) produces opposite responses in the predicted EGFR target genes SOCS2 and NR2E1.

    Mol Syst Biol 2011 7, 486. Gefitinib (ZD1839) purchased from Selleck.

  • Effects of shRNA-mediated RECK depletion on EGFR signaling in MEFs. (a) Immunoblotting (IB) of the indicated proteins in wild-type MEFs transduced with the indicated shRNAs and cultured for 48 h in the presence of 0.1% dimethyl sulfoxide (DMSO; vehicle) or 1 mM gefitinib (S1025, Selleck Chemicals,Houston, TX, USA). (b) Immunoprecipitation from whole lysates of cells from panel a with an anti-phosphorylated tyrosine (pTyr) antibody. Precipitates from 500 mg protein in whole cell lysates (upper) or 20 mg protein in whole cell lysates (lower) were analyzed by IB with anti-EGFR antibody.

    Oncogene 2010 30, 737-750. Gefitinib (ZD1839) purchased from Selleck.

    (B–C) LNCaP (B) and LNCaP-AI (C) cells were transiently transfected with sPLA2-IIa(-800)-Luc (0.5 μg). The cells were then treated with Erlotinib (20 μM), Gefitinib (20 μM), Lapatinib (20 μM), CI-1033 (8 μM), LY294002 (20 lM) and Bortezomib (20 μM) without or with EGF (100 ng/ml) for 24 h. Luciferase assay was performed according to a standard protocol with Renilla luciferase as an internal control. Data are presented as the mean (±SD) of duplicate values of a representative experiment that was independently repeated for five times.

    Carcinogenesis 2010 31, 1948–1955 . Gefitinib (ZD1839) purchased from Selleck.

  • LNCaP-AI cells were starved in 1% stripped medium for 24 h. The cells were then treated with Erlotinib (20 μM), Gefitinib (20 μM), Lapatinib (20 μM), CI-1033 (8 μM), LY294002 (20 μM) and Bortezomib (20 μM) for 24 h. Cell culture medium was collected from each sample and subjected to ELISA for sPLA2-IIa. The condition medium samples were diluted 10 times for ELISA. Average of duplicate samples was converted to nanogram per milliliter against standard curve. The data represent one of five repeated experiments.

     

     

    Carcinogenesis 2010 31, 1948–1955. Gefitinib (ZD1839) purchased from Selleck.

    Suppression of EGFR signaling by Gefitinib is dose dependent and non- toxic at millimolar concentrations.Results from plaque reduction tests of Hep2 cells infected with VACV(12.5pfu/well) treated with a serial dilution of Gefitinib (1000-0.01 m) and analyzed for (A)proliferation as indicator of cytotoxicity,(B) IC50 of plaque size inhibition, (C)dose dependent inhibition of EGFR-ERK1/2signaling and VACV proteins by Western blot analysis (pEGFR detection was obtained from a different experiment with identicals ettings) and (D)dose dependent inhibition of orthopoxvirus genome replication by real-time PCR.Untreated VACV infectedcells and uninfected cells are shown as controls in the right panel.

    Antiviral Res 2010 89, 64-70. Gefitinib (ZD1839) purchased from Selleck.

  • A circular zone of EGFR activated but uninfected cells facilitate virus induced plaque development , efficiently blocked by Gefitinib. (A)Immun of luorescent staining of aplaque reduction tests with Hep2 cells 24,48,72 and 96 h after VACV infection (6.25pfu/chamber). VACV infected cells(green) were visualized by human IgG directed to orthopoxviruses (VIG) detected with a secondary FITC labelled antibody. Uninfected cells with activated EGFR signaling(red) are detected with a secondary Cy3labelled antibody. Positive cells for both , VACV and phosphorylated EGFR are shown in yellow(merge). Cellular nuclei are counterstained with DAPI. (B)Immunofluorescent staining of a plaque reduction test as described for (A) and treated with three different Gefitinib concentrations (1000 nM, 1 nM, and 0.01 nM) . The test was analyzed 96h afterVACV infection.Uninfected cells are shown as controls. Magnification100×.(For interpretation of the references to color in this figure legend , the reader is referred to the web version of the article.)

     

     

    Antiviral Res 2010 89, 64-70. Gefitinib (ZD1839) purchased from Selleck.

    Susceptibility of lung cancer cells to cytolytic activity of NK-92 cells after treatment with EGFR inhibitors. Three lung cancer cells were untreated (open circle) or treated with 10 μM erlotinib or gefitinib (black filled square or black filled triangle) for 24 hours. The lung cancer cells were cocultured with NK-92 cells at indicated effector to target ratio (E:T ratio). To determine the specificity of NKG2D-mediated cytolysis of lung cancer cells, NK-92 cells were preincubated with blocking mAb against NKG2D before the assay (gray filled square and triangle) and correspond-ing isotype mAb (open square and triangle).

    J Immunother 2011 34(4), 372-81. Gefitinib (ZD1839) purchased from Selleck.

  • Inhibition of 5-HT-induced 5-HT3A and 5-HT3AB receptor currents.

    Eur J Pharmacol, 2017, 821:21-28. Gefitinib (ZD1839) purchased from Selleck.

    The EGF-dependent increased association of PCM1 and AZI1 requires EGFR kinase activity. ZD1839 (Iressa)—EGFR tyrosine kinase inhibitor.

    Mol Biosyst 2011 7, 3223-33. Gefitinib (ZD1839) purchased from Selleck.

  • Reduction of GPER expression in HCC1806 cells after treatment with gefitinib. (A) Concentration dependence. HCC1806 cells were treated with 50-500 nM gefitinib for 48 h. GPER was detected by western blotting. (B) Time dependence. HCC1806 cells were treated with 200 nM gefitinib for 24-96 h. ap<0.05 vs. control; bp<0.001 vs. control. Mean values and SE of three independent experiments are shown. (C) Representative western blotting of concentration dependence. (D) Representative western blotting of time dependence

    Oncol Rep, 2017, 37(2):1212-1218. Gefitinib (ZD1839) purchased from Selleck.

    Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 215496. Gefitinib (ZD1839) purchased from Selleck.

  • Breast cancer cells were pretreated with 100ng/ml EGF for 15 min and then treated with the indicated concentrations of  Gefitinib for 24 hours.

     

     

    2010 Dr. Zhang of Tianjin Medical University. Gefitinib (ZD1839) purchased from Selleck.

    MTT assay result. 0-500nM Gefitinib treated with H1299, H358, H25 and HCC827 cell lines by 72h, Proliferation rate was tested.

     

     

    2010 Dr. Vicky Tin from University of Hong Kong. Gefitinib (ZD1839) purchased from Selleck.

製品安全説明書

EGFR阻害剤の選択性比較

生物活性

製品説明 Gefitinib (ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.
特性 A potent EGFR tyrosine kinase inhibitor.
ターゲット
Tyr1173 (NR6W cells) [1] Tyr1173 (NR6wtEGFR cells) [1] Tyr992 (NR6wtEGFR cells) [1] Tyr992 (NR6W cells) [1]
26 nM 37 nM 37 nM 57 nM
体外試験

Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low-EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition. Gefitinib effectively blocks the phosphorylation of PLC-γ, with IC50 of 27nM, in NR6W cells. The NR6wtEGFR and NR6M cell lines has low levels of PLC-γ phosphorylation but the level in the NR6M cell line is more resistant to inhibition by Gefitinib with IC50 of 43 nM and 369 nM, respectively. Gefitinib inhibits Akt phosphorylations, with IC50 of 220 and 263nM, in the low-EGFR- and -EGFRvIII-expressing cell lines, respectively. Gefitinib in the dose range from 0.1 to 0.5μM significantly facilitates, rather than abrogates, colony formation of NR6M cells. However, at a concentration of 2 μM Gefitinib completely blocks NR6M colony formation. Gefitinib rapidly and in a dose-dependent manner inhibits EGFR and ERK phosphorylation up to 72 hours after EGF stimulation in both the high- and low-EGFR-expressing cell lines. [1] Gefitinib is the monolayer growth of these EGF-driven untransformed MCF10A cells with an IC50 of 20 nM. [2] The combination of Gefitinib (0.2 μM and 0.5 μM) with irradiation lead to a significant growth inhibition in LoVo cells, compared with radiation alone.. [3]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KB MnHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjsV3R{UUN3ME2wMlA2PCEQvF2= Ml7zNVY2OTZ2N{O=
NIH3T3 NHrIT2VHfW6ldHnvckBCe3OjeR?= Ml3mNE4zKM7:TR?= NVrMZWRpOiCq MXTEUXNQ NWTxNWdOUW6qaXLpeIlwdiCxZjDFS2Yhe3SrbYXsZZRm\CCqdX3hckBmemKEMTDheZRweGixc4Doc5J6dGG2aX;uJJdqfGhiSVO1NEBw\iByLkCxOFQh|ryP MmnENVY1QDB{OES=
COS7 MX\GeY5kfGmxbjDBd5NigQ>? MUK5OkDPxE1? MXvJcohq[mm2aX;uJI9nKGi3bXHuJGpCUzJiVk[xO2YhdXW2YX70JIV5eHKnc4Pl[C=> M1TDPVE4OTd6N{Ky
A549 MYPDfZRwfG:6aXOgRZN{[Xl? NWj2boRrQTZiaB?= MVPEUXNQ NHjqTXdKSzVyPUGzMlU6KM7:TR?= NEPUcIkyQDNzM{iwOy=>
K562 MX\DfZRwfG:6aXOgRZN{[Xl? MU[5OkBp NYTnPYM1TE2VTx?= NVP1THF1UUN3ME25MlM3KM7:TR?= M3XxeFE5OzF|OEC3
MDA-MB-231 M4j1O2N6fG:2b4jpZ{BCe3OjeR?= NETBPHI6PiCq M3rDVWROW09? MWDJR|UxRTN4Lk[xJO69VQ>? NI[wc2EyQDNzM{iwOy=>
MOLT4 NXPpXldwS3m2b4TvfIlkKEG|c3H5 MUe5OkBp NYnmTIJqTE2VTx?= M1\1UWlEPTB;MUWuNFIh|ryP NUTm[G1vOTh|MUO4NFc>
MCF7 NGfM[4REgXSxdH;4bYMhSXO|YYm= NFzO[4E2OCEQvF2= M3eyclczKGh? M3HZWmlEPTB;MUKuNFUh|ryP NWXkZWM6OTh5N{G4NVk>
BT474 NVLzfWl3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1ToSVczKGh? NH3lN2pCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFLUOFc1KGOnbHzzJI93\XKneIDy[ZN{cW6pIFXSRoIzKHerdHigSWM2OCCxZjCwMlMh|ryP NVfFN4d{OTlyMki0NlQ>
HN5 NUTwZ4VKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUC3NkBp NVjZbIFsSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIUlUh[2WubIOgc5ZmemW6cILld5NqdmdiRVfGVkB4cXSqIFXDOVAhd2ZiMD6wNUDPxE1? M3j5XFE6ODJ6NEK0
BA/F3 MV;DfZRwfG:6aXOgRZN{[Xl? NUHwVYtzPzJiaB?= Mn7LR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgRmEwTjNiY3XscJMh\XiycnXzd4lv\yCHR1\SJGw5PTiUIH31eIFvfCC5aYToJGlEPTBib3[gNE4xOTB6IN88US=> NFXJW3kyQTJ|OUKyPS=>
NIH3T3 NGD5XWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDKVZNXPzJiaB?= MV\Hdo94fGhiaX7obYJqfGmxbjDv[kBud3W|ZTDOTWgwO1R|IHPlcIx{KGW6cILld5NqdmdiZYLCNkBo\W6nIIfpeIghUUN3MDDv[kAxNjV2IN88US=> NUXBRYVTOTl4NkWzO|c>
MCF7 MX NV65O3E5TnWwY4Tpc44hSXO|YYm= NGDU[2Y{OCCvaX6= MlzyTY5pcWKrdHnvckBw\iCEQ2LQJIV5eHKnc4Pl[EB4cXSqIFnDOVAhd2ZiMT6xJO69VQ>? MXGxPVk{Ojl4MB?=
A431 M3zJfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF70XZUyOCEQvF2= M1[0NVczKGh? NYrS[YdbT0l3ME2wMlUyPCEQvF2= MYixPVk3QTR4NR?=
A431 NIXuSHJMcW6jc3WgRZN{[Xl? MXuwMlEh|ryP NEm1SZAyKGh? NIjKb4xKdmirYnn0bY9vKG:oIFXHSk1qdmS3Y3XkJGVITlJicHjvd5Bpd3K7bHH0bY9v MX[xPVk3QTR4NR?=
A431 MmfDT4lv[XOnIFHzd4F6 MoXONVAxKM7:TR?= MVmxNEBucW5? MVvQdo9td26pZXSgbY5pcWKrdH;yfUBi[3Srdnn0fUBw\iCHR1[tbY5lfWOnZDDFS2ZTKHCqb4PwbI9zgWyjdHnvci=> MWexPVk3QTR4NR?=
Sf9 NE\OZldMcW6jc3WgRZN{[Xl? NInnfmkyOCCvaX6= M1P4fmROW09? Mon4TY5pcWKrdHnvckBw\iCHR1\SJIV5eHKnc4Pl[EBie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJJm[2WydH;yJIF2fG:yaH;zdIhwenmuYYTpc44hf2m2aDDJR|UxKG:oIECuNFM{KM7:TR?= NIfwd|kzODB3NkSyOS=>
NCI-H1975 MoPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWW1JO69VQ>? NH;lTWg4OiCq MoTOTWM2OD16LkK2JO69VQ>? MUOyNFE2OTZ5MB?=
NCI-H1975 M2ftTmtqdmG|ZTDBd5NigQ>? MYCxNEDPxE1? NGD5cYpKdmirYnn0bY9vKG:oIFXHSnIh[XW2b4Doc5NxcG:{eXzheIlwdg>? M2jo[VIxOTVzNkew
NCI-H1975 M1:1cWZ2dmO2aX;uJGF{e2G7 M4LjZVExKM7:TR?= M4iyNWlvcGmkaYTpc44hd2ZiRWLCRlIh[XW2b4Doc5NxcG:{eXzheIlwdg>? M{LPWFIxOTVzNkew
NCI-H1975 NGrv[lhHfW6ldHnvckBCe3OjeR?= MV[1JO69VQ>? NUf0S25vPDhiaB?= M1fDfmlv\HWldHnvckBw\iCjcH;weI9{cXNiYYPz[ZN{\WRiYYOgZYN1cX[jdHnvckBw\iClYYPwZZNmNTN? MX2yNFE2OTZ5MB?=
A375 NWLPPXBlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXsT|hZPDhiaB?= M3jFfGlEPTB;MkCuOVUh|ryP NHXhfFEzODNyNEWzOy=>
SMMC7721 NGS5RmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvwNmc1QCCq M{jlNmlEPTB;M{OuNVIh|ryP M{CxSlIxOzB2NUO3
DU145 NYnXVIgzS3m2b4TvfIlkKEG|c3H5 M4\HXlUh\A>? MVzEUXNQ NVjFTlZqUUN3ME20Nk4yPyEQvF2= M4f2TFIxPDZ4NUW1
MIAPaCa2 MnnJR5l1d3SxeHnjJGF{e2G7 NX;2VI9vPSCm M{PabmROW09? MlG1TWM2OD13MD62NkDPxE1? NX7iT|N7OjB2Nk[1OVU>
PANC1 MmTxR5l1d3SxeHnjJGF{e2G7 MYS1JIQ> MV3EUXNQ MYjJR|UxRTRyLkSyJO69VQ>? MnTGNlA1PjZ3NUW=
PC9 MmHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUS5XIV3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBGT0[ULXTl[olkcWWwdDDoeY1idiCSQ{mgZ4VtdHNid3n0bEBGSzVyIH;mJFAvODF5IN88US=> NVP3cXprOjF{MEi4NFI>
PC9 NWr1SmFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XFdmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4Sg[5Jwf3SqLYLld4l{fGGwdDDoeY1idiCSQ{mgZ4VtdHNiZYjwdoV{e2mwZzDFS2ZTKEV5NE\fRVc2OC:WN{mwUUBufXSjboSge4l1cCCHQ{WwJI9nKDdizszN MoPzNlEzODh6MEK=
PC3 MmjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDEOoV7OTBizszN NHy2Uoo4OiCq M4jZTWROW09? MmfTTWM2OD15LkSg{txO MkW2NlE{PTN3NE[=
MDA-MB-468 NVSwfHh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG[xUocyODBizszN NX;UPGY3PDhiaB?= MnW4SG1UVw>? NXnST3d4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJk> M13WflIyPDJ7NkOy
Plasmodium falciparum MorldWhVWyCycn;mbYxqdmdiZn;yJIlvcGmkaYTvdpMhd2ZiUHzhd41w\Gm3bTDmZYxkcXCjcoXtJJBzd2yrZnXyZZRqd25? M2D1VlIyQDF5MES1
NCI-H1993 NGLCT|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnS0O|IhcA>? NXH6RXdZTE2VTx?= NH[3[YRKSzVyPUCuNUDPxE1? MUOyNVkyPjR|Mx?=
NCI-H292 M2DIe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnjb5c4OiCq NWrBNYFYTE2VTx?= NWDOOVVmUUN3ME2wMlAzKM7:TR?= NHTRZVEzOTlzNkSzNy=>
A431 NGnzWGRMcW6jc3WgRZN{[Xl? NYnSZ4tzOiCq NI\6[VJFVVOR NVjDcWx[UW6qaXLpeIlwdiCxZjDFS2ZTKHCqb4PwbI9zgWyjdHnvckBqdiCHR1[td5RqdXWuYYTl[EBpfW2jbjDBOFMyKHerdHigTWM2OCCxZjCwMlAxOSEQvF2= M2HPNlIzOTBzMUOy
MCF7 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXNNpYyODEEoN88[{9uVA>? NX3jR4lUPDhiaB?= NW\KeW56TE2VTx?= MVrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNib4\ldoV5eHKnc4PpcochTUeIUjDn[Y5mKHerdHigTWM2OCCxZjCxNk4xPSEQvF2= NEe0UGgzOjFzOUGzNC=>
BT474 MYXDfZRwfG:6aXOgRZN{[Xl? MYCxNEDPxE1? M4jIdVQ5KGh? NYfScXV1S3m2b4TvfIlkcXS7IHHnZYlve3Ric3XyeY0ue3Sjco\l[EBpfW2jbjDCWFQ4PCClZXzsdy=> NGP6d2MzOjF|OEOwPC=>
MCF7 MYfDfZRwfG:6aXOgRZN{[Xl? M4PERVExKM7:TR?= NUPuR5JwPDhiaB?= MlXXR5l1d3SxeHnjbZR6KGGpYXnud5Qhe2W{dX2td5Rien[nZDDoeY1idiCPQ1[3JINmdGy|IH;2[ZIu\XiycnXzd4lv\yCHcnLCNkBk\Wyucx?= NH3ZRlQzOjF|OEOwPC=>
HCC827 MXfLbY5ie2ViQYPzZZk> NIH2S2MxNjF{NTFOwG0> MYOyOEBp MmG4SG1UVw>? M3z3SmlvcGmkaYTpc44hd2ZiRVfGVkBl\WxiRUe0Ok1CPzVyIH31eIFvfCC\MUC2PEBifXSxcHjvd5Bpd3K7bHH0bY9v M1fwWVIzOzN7M{Sy
HCC827 NHroVJNMcW6jc3WgRZN{[Xl? NVHKOFNnOC5zMkWg{txO NH;tc5czPCCq MlXPSG1UVw>? MkLWTY5pcWKrdHnvckBw\iCHR1\SJIRmdCCHN{S2MWE4PTBibYX0ZY51NW2nZHnheIVlKEW{azDwbI9{eGixconsZZRqd25? MkfDNlI{Ozl|NEK=
HCC827 NHfJT|VMcW6jc3WgRZN{[Xl? M2TOWlAvOTJ3IN88US=> M4GxelI1KGh? NW[ydXJ{TE2VTx?= NXXFPY5iUW6qaXLpeIlwdiCxZjDFS2ZTKGSnbDDFO|Q3NUF5NUCgcZV1[W62LX3l[IlifGWmIFHreEBxcG:|cHjvdplt[XSrb36= MUGyNlM{QTN2Mh?=
A431 MkHOT4lv[XOnIFHzd4F6 NYW1TXFWOTByIN88US=> M3q2PFMxKG2rbh?= MmniTY5pcWKrdHnvckBw\iCHR1\SJIRmemm4ZXSg[pJwdSCqdX3hckBCPDNzIHPlcIwhdWWvYoLhcoUh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBxd2y7LVfseU1VgXJicHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCxMlA5KM7:TR?= NGDsd3UzOjZ7OEe4Ni=>
H460 NXTaXWdrS3m2b4TvfIlkKEG|c3H5 MYC3NkBp NXv4fmZsUUN3ME21MlU6KM7:TR?= NYn1bYFtOjJ5Mke0OFk>
HT-29 MVPDfZRwfG:6aXOgRZN{[Xl? NE\CbGo4OiCq MUXJR|UxRTNwM{[g{txO M{XZT|IzPzJ5NES5
SGC7901 NXz5PIE6S3m2b4TvfIlkKEG|c3H5 NXXkSGpGPzJiaB?= NFLieZVKSzVyPUGwMlI3KM7:TR?= M{PGdlIzPzJ5NES5
A498 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF2OUigZ4VtdHNiZYjwdoV{e2mwZzDFS2ZTKGGwZDDTVmMhf2m2aDDJR|UxKG:oIEiuOkDPxE1? NIi2VXczOjhzOEi0PC=>
Calu3 NIHKNJpEgXSxdH;4bYMhSXO|YYm= M17PXlExKM7:Zz;tUC=> MoTBO|IhcA>? M1TKNmlEPTB;MT62JO69VQ>? NEnmUJMzOzFzNkG2PC=>
FADU MUPDfZRwfG:6aXOgRZN{[Xl? MXyxNEDPxGdxbVy= NVXNOZdHPzJiaB?= NXy0bWxPUUN3ME2wMlA2KM7:TR?= NILGNZEzOzFzNkG2PC=>
HCC827 NV70V3JwS3m2b4TvfIlkKEG|c3H5 M1\HVlExKM7:Zz;tUC=> NYrCN2VpPzJiaB?= NWPOR5pZUUN3ME2wMlAxOTVizszN MYeyN|EyPjF4OB?=
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A498 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTJwMkm0NVUh|ryP NVXpOnYyW0GQR1XS
IGROV-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;CTWM2OD1{LkOxNlM4KM7:TR?= MlHYV2FPT0WU
JVM-3 M1nrcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjPTWM2OD1{LkO0OlQ{KM7:TR?= NUjxO3d3W0GQR1XS
NCI-H2170 M2i2PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;WTWM2OD1{LkO0O|g{KM7:TR?= NVnUVHM2W0GQR1XS
EW-18 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTJwM{W0O|Eh|ryP NV7BeYxKW0GQR1XS
KU812 NGjFTJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTJwM{[3O|kh|ryP M{XYSHNCVkeHUh?=
NY M{HKWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPRTWM2OD1{LkO3Nlch|ryP MnjkV2FPT0WU
HTC-C3 NEPCXnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkCxTWM2OD1{LkSyNlY4KM7:TR?= M3;BcnNCVkeHUh?=
CFPAC-1 MkXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPjRmdKSzVyPUKuOFM5PjRizszN MlnlV2FPT0WU
HH NELPVIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkS5TWM2OD1{LkS5PFU1KM7:TR?= M33kR3NCVkeHUh?=
MKN7 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXF[GpKSzVyPUKuOlI4PDhizszN NEL6Xo5USU6JRWK=
TE-8 M1\GeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLNeYVGUUN3ME2yMlY{PjV|IN88US=> NHnuNZpUSU6JRWK=
MC-IXC MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jpeWlEPTB;Mj62OFQ2OyEQvF2= M1u3UnNCVkeHUh?=
DMS-79 NILWTJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLYTWM2OD1{Lk[5Nlg1KM7:TR?= M4PLNXNCVkeHUh?=
Detroit562 NFrvUm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HDe2lEPTB;Mj62PVg1PSEQvF2= Mmq3V2FPT0WU
HuP-T4 MoPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\kTWM2OD1{LkeyPFE5KM7:TR?= NHjT[nBUSU6JRWK=
QIMR-WIL NIfJbFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHv3PIdKSzVyPUKuO|U6PTJizszN NVrFW4pKW0GQR1XS
BB65-RCC MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PFZ2lEPTB;Mj64NFcyOyEQvF2= MoTvV2FPT0WU
PC-3 M17Ydmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTJwOEOzNVch|ryP NFH2dHRUSU6JRWK=
OVCAR-3 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTTelhlUUN3ME2yMlg2PTl2IN88US=> MlvQV2FPT0WU
KYSE-510 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELsS4dKSzVyPUKuPFY4QDZizszN MVnTRW5ITVJ?
HC-1 Mn6wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PHWmlEPTB;Mj65OFAyOiEQvF2= NGTnVYxUSU6JRWK=
NCI-H1693 NGPoWFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTJwOUW4PVch|ryP NEjXRoVUSU6JRWK=
DU-4475 NEDMTlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPqTWM2OD1{Lkm5NFUzKM7:TR?= MYjTRW5ITVJ?
COLO-680N NXHMRphET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmi5TWM2OD1|LkCwOFk2KM7:TR?= M2XyT3NCVkeHUh?=
MN-60 MnPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnpTWM2OD1|LkC0PVc1KM7:TR?= NF\xcmlUSU6JRWK=
BCPAP MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvQeGVKSzVyPUOuNFgzQTVizszN NELiUoVUSU6JRWK=
647-V Mof2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTNwMU[yNkDPxE1? MVTTRW5ITVJ?
HT-1376 NFnWTINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPBWWo6UUN3ME2zMlIxPTB4IN88US=> NYjIXmxQW0GQR1XS
NCI-H1793 M1zkdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3vd4FKUUN3ME2zMlIyODl6IN88US=> M{\FZnNCVkeHUh?=
SW1463 MlPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPsZWNPUUN3ME2zMlI3OTl{IN88US=> M1P3RnNCVkeHUh?=
NCI-H727 MnHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jFWmlEPTB;Mz6zPFU5PCEQvF2= NU\kcWI1W0GQR1XS
LB771-HNC NGO0VphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVflVo52UUN3ME2zMlM6OTJ4IN88US=> NFzwPIJUSU6JRWK=
D-542MG NIXsdXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrPXllKSzVyPUOuOFQzOjJizszN MkL0V2FPT0WU
NTERA-S-cl-D1 NWL4c4hNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTJfWdMUUN3ME2zMlQ1QTV5IN88US=> NXPLZ5lpW0GQR1XS
C8166 NXvEe5ZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTNwNE[1NlEh|ryP NXnEWFJKW0GQR1XS
639-V NXrqeZhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TKTGlEPTB;Mz61O|c6OiEQvF2= MnPFV2FPT0WU
TE-1 NEK0e3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrT[XFzUUN3ME2zMlU6OTZ7IN88US=> Ml;jV2FPT0WU
OAW-28 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1u3PGlEPTB;Mz61PVQzPiEQvF2= NHXET2RUSU6JRWK=
SK-LU-1 MomyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTNwNkC2OFUh|ryP MoLsV2FPT0WU
CaR-1 NV;obnJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXRTYNKSzVyPUOuOlExPDhizszN MX3TRW5ITVJ?
A2780 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTNwNkSwPFkh|ryP MV;TRW5ITVJ?
C2BBe1 NF7iW|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrj[oZKSzVyPUOuOlQ1ODdizszN NGTIcVJUSU6JRWK=
SK-MES-1 NUn4ZlJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfmOZpKSzVyPUOuOlQ3OTRizszN M4XtdXNCVkeHUh?=
PANC-10-05 M3LUbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTNwN{KwO|Ih|ryP Mn60V2FPT0WU
J-RT3-T3-5 NIDVbplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW[5PIlrUUN3ME2zMlc2PDB4IN88US=> MX\TRW5ITVJ?
ES4 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\XTWM2OD1|LkiyNlg3KM7:TR?= MVrTRW5ITVJ?
NCI-H28 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\XTWM2OD1|LkiyPVYyKM7:TR?= NXPnVXZVW0GQR1XS
NCI-H1155 M{P2eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTXUo9KSzVyPUOuPFQyPTlizszN NFPtcnhUSU6JRWK=
KURAMOCHI MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPNTWM2OD1|Lki2NFU3KM7:TR?= NXrBXFlkW0GQR1XS
NCI-H69 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHCcmJKSzVyPUOuPVAyPzhizszN NYXxSlVEW0GQR1XS
IST-MES1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHG4PGhKSzVyPUOuPVQxOjlizszN MVvTRW5ITVJ?
NH-12 NGK4ZnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW[5d5l6UUN3ME2zMlk1OTh5IN88US=> MUTTRW5ITVJ?
JVM-2 NHi5dHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHlTWM2OD1|Lkm0O|UzKM7:TR?= MkTaV2FPT0WU
EW-16 MoLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vCTWlEPTB;Mz65OVU4PyEQvF2= MVLTRW5ITVJ?
NCI-H441 M2HKNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTNwOUewNVQh|ryP NFq4bnZUSU6JRWK=
RCC10RGB NFjUNXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTRwMEGyOFYh|ryP MYrTRW5ITVJ?
TCCSUP NH;KNJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrDfGJFUUN3ME20MlEyODVizszN NX31UZJVW0GQR1XS
HL-60 MmrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkn3TWM2OD12LkGyNlQyKM7:TR?= MWrTRW5ITVJ?
EW-11 M2i4d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYC0XHFPUUN3ME20MlE{OjZzIN88US=> MVPTRW5ITVJ?
KARPAS-299 NXHhZml1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlX1TWM2OD12LkOxNFE{KM7:TR?= Mo\KV2FPT0WU
SNU-C2B M1XGTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHuTWM2OD12LkO0Olg3KM7:TR?= Mn7oV2FPT0WU
LU-139 MlTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vzT2lEPTB;ND6zO|I1PyEQvF2= MVvTRW5ITVJ?
HCC1937 Mo\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIW4SHNKSzVyPUSuN|c6QTNizszN MYDTRW5ITVJ?
GR-ST MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;idZQ3UUN3ME20MlQ{OThizszN NG\xe2dUSU6JRWK=
SK-OV-3 NYSyc2hnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo[3TWM2OD12LkS2NFQzKM7:TR?= M2[zXHNCVkeHUh?=
A172 NVHJW2NbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPPd|JIUUN3ME20MlU2PTJzIN88US=> NHTXNFdUSU6JRWK=
NB10 MkTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3[2TGlEPTB;ND61PVc5OSEQvF2= MWXTRW5ITVJ?
P30-OHK MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;pTWM2OD12LkixPVI6KM7:TR?= M3O2SnNCVkeHUh?=
KYSE-520 NXW2dJRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTRwOEiwNVgh|ryP MoLCV2FPT0WU
KNS-62 NHmxWmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTP[4VKSzVyPUSuPVA5ODdizszN M3KyXXNCVkeHUh?=
ES1 NY\jT29mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzUZ|lbUUN3ME20Mlk3ODN3IN88US=> M4e4VHNCVkeHUh?=
KOSC-2 Mn\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nvdGlEPTB;ND65PVk2QSEQvF2= NGfGTVdUSU6JRWK=
TE-9 MkD6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vOe2lEPTB;NT6wNVUzPSEQvF2= MomyV2FPT0WU
NCI-H1838 M3vFTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHOxNIRKSzVyPUWuNFIxPzZizszN MoHyV2FPT0WU
KP-N-YN NHP3R25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTVwMUK1PVEh|ryP MYDTRW5ITVJ?
ALL-PO M2HOPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHS1UZFKSzVyPUWuNlI2QDdizszN MlvjV2FPT0WU
NOMO-1 Mnm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTVwMkOxO|Yh|ryP NYnmeXJUW0GQR1XS
CGTH-W-1 M{e3OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3ic2dKSzVyPUWuN|g2QDRizszN NXL3U2NlW0GQR1XS
ATN-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrxTWM2OD13LkSxNVg1KM7:TR?= NFLhe4dUSU6JRWK=
AGS NGi0[3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTVwNEm2NVgh|ryP NYDZZ3FLW0GQR1XS
SW13 NGLnNVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\2SZp5UUN3ME21MlU{OjZ3IN88US=> NWjy[41tW0GQR1XS
SW1990 NUXPUVQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PWd2lEPTB;NT62NlI5PSEQvF2= M2KyNHNCVkeHUh?=
BFTC-905 M4jxcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTSTWM2OD13Lk[1PFc5KM7:TR?= NYnTcVFkW0GQR1XS
RMG-I MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHpTWM2OD13Lk[1PVQzKM7:TR?= M32wZnNCVkeHUh?=
HD-MY-Z NI\rOlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfpTWM2OD13Lk[4OVgyKM7:TR?= MYfTRW5ITVJ?
HCC1187 NU\idHI1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DWcGlEPTB;NT63NVA{OiEQvF2= NIXyXHZUSU6JRWK=
HCC2998 NYTDbHd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHITWM2OD13LkexPFc4KM7:TR?= MVzTRW5ITVJ?
RT-112 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jKemlEPTB;NT65NFI1PSEQvF2= M4\2THNCVkeHUh?=
CAKI-1 NGHTZZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljnTWM2OD14LkCwPVg2KM7:TR?= M3m4cHNCVkeHUh?=
HDLM-2 M2rXbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTZwMEG0PFkh|ryP NYLWfFREW0GQR1XS
TE-10 MkjSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHE[lNKSzVyPU[uNFQ5OzNizszN NEK4bGRUSU6JRWK=
KE-37 NFOwbWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfaOItKSzVyPU[uNFczPThizszN NIfoZVNUSU6JRWK=
RCM-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnrVXVRUUN3ME22MlA4PzF7IN88US=> M3\6OnNCVkeHUh?=
Mewo M{jh[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnZNHdLUUN3ME22MlEyPDh5IN88US=> MlPNV2FPT0WU
L-428 M2mzb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\yTmlEPTB;Nj6xPFA{PyEQvF2= Mk\YV2FPT0WU
8-MG-BA M3[zbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LPWGlEPTB;Nj6xPVM4QSEQvF2= Mk\FV2FPT0WU
SK-MEL-28 MmPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\CT4JKSzVyPU[uNlA6PjdizszN NHrlSVRUSU6JRWK=
VA-ES-BJ M1XKe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVO4WXB3UUN3ME22MlMxPDZ{IN88US=> NFPrOHVUSU6JRWK=
CAL-120 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HDNGlEPTB;Nj60OVE3OiEQvF2= M2S1PXNCVkeHUh?=
GAMG M13VWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7JPIZRUUN3ME22MlUxPjJizszN M{jMW3NCVkeHUh?=
MSTO-221H MmDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1v0VGlEPTB;Nj61NVE4KM7:TR?= NGjaVHdUSU6JRWK=
GCT M13iZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXHTWM2OD14LkWzN|g4KM7:TR?= M2TPb3NCVkeHUh?=
SH-4 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTZwNUi4OFQh|ryP NUDtSItIW0GQR1XS
Calu-3 NEHoWWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFflcFlKSzVyPU[uOlU2PjhizszN MW\TRW5ITVJ?
SK-HEP-1 NGLJOINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDhbIF7UUN3ME22MlcyPzV|IN88US=> M2LMenNCVkeHUh?=
PFSK-1 NX36bo13T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILiSnJKSzVyPU[uO|M1PzhizszN NYCwXG53W0GQR1XS
NB12 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvXTWM2OD14Lke4OFA1KM7:TR?= NXzPcZZ5W0GQR1XS
A388 NYTndFVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDxcFlKSzVyPU[uPFk2OiEQvF2= NIXrU21USU6JRWK=
KLE Mlm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DPemlEPTB;Nj65OlUyPiEQvF2= NU\PSnhHW0GQR1XS
TE-11 M{Pxe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUe1cGJPUUN3ME23MlA1QTZ5IN88US=> MYnTRW5ITVJ?
NCI-H2405 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfqTWM2OD15LkC4N|k{KM7:TR?= MV3TRW5ITVJ?
OVCAR-4 NHzqWnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTdwMUWzOUDPxE1? MUTTRW5ITVJ?
KP-N-YS NWHZVZdkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTdwMUixOEDPxE1? NVzHOGJHW0GQR1XS
NOS-1 M3PlR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;DbmlEPTB;Nz6yOVgzQCEQvF2= Ml7iV2FPT0WU
DMS-114 NX;IV4lCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHKxc2dKSzVyPUeuNlk3OzFizszN Mnv5V2FPT0WU
NCI-H2030 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrRTWM2OD15LkOzOlk5KM7:TR?= M3nLZXNCVkeHUh?=
HEL MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\ZWWlEPTB;Nz6zO|UzOSEQvF2= M1rZT3NCVkeHUh?=
CAL-62 Mn3lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LQN2lEPTB;Nz6zPVg3PiEQvF2= NXH0enlsW0GQR1XS
COLO-668 NHfuWnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfYdWd[UUN3ME23MlQ{QTZ5IN88US=> NFrpUnhUSU6JRWK=
SKG-IIIa M{O5V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTdwNEWzPFEh|ryP M3L3fnNCVkeHUh?=
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LC-2-ad NFqyUlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1T0b2lEPTB;M{[uOlk6KM7:TR?= NH;RN4dUSU6JRWK=
IGR-1 M4LQWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTN4LkewO|Uh|ryP M1Xnc3NCVkeHUh?=
SW626 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjORpFKSzVyPUO3MlA1OTdizszN NUnlPYJNW0GQR1XS
ONS-76 NVry[5hCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjZU4NwUUN3ME2zO{4yOzB7IN88US=> MlPVV2FPT0WU
T98G M2Xnb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTN5Lki2N|Uh|ryP NU\DSocxW0GQR1XS
NB14 M{X2WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGj2V3dKSzVyPUO4MlQ2PDRizszN MYjTRW5ITVJ?
D-423MG MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fRfmlEPTB;M{iuOFg3QSEQvF2= MX3TRW5ITVJ?
NCI-H510A M{DuRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TIdWlEPTB;M{iuOlQ2OSEQvF2= NUDR[nVCW0GQR1XS
NMC-G1 Ml;PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHL1bGdKSzVyPUO4MlczOjJizszN NVG0NlI5W0GQR1XS
SW948 Mk\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rNbGlEPTB;M{iuPFk1QSEQvF2= MYDTRW5ITVJ?
MFM-223 NVO5UmF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfHb2xKSzVyPUO4Mlk1OzFizszN MkDPV2FPT0WU
PAN1 M4W2cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PzeGlEPTB;M{iuPVkyQSEQvF2= MkLKV2FPT0WU
MZ7-mel M3;GdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PtXGlEPTB;M{muNVE6QSEQvF2= NHnSWoZUSU6JRWK=
COLO-679 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXqTWM2OD1|OT65O|A5KM7:TR?= MW\TRW5ITVJ?
SW872 NXzMUlUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHyzUmxKSzVyPUSwMlIxOzFizszN MXzTRW5ITVJ?
HT-1197 M2\GOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXpTWM2OD12MD6yPFY6KM7:TR?= NFjm[YpUSU6JRWK=
ES6 NULtWVF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrwUYl2UUN3ME20NE41PTV{IN88US=> NWTDZXNSW0GQR1XS
SNU-387 M2LNcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjMd5ZKSzVyPUSwMlgzOzhizszN NUnmUGV5W0GQR1XS
T47D MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVi4N5FFUUN3ME20NU4xOTl{IN88US=> MVrTRW5ITVJ?
G-402 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnxXpZIUUN3ME20NU4xQDB7IN88US=> NH32U5pUSU6JRWK=
MZ1-PC NIjWeG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPYTWM2OD12MT64NUDPxE1? M3ziNXNCVkeHUh?=
SW1417 NYW3XHoxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmGzTWM2OD12Mj6zNFMh|ryP MnvsV2FPT0WU
RERF-LC-MS M2nRUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTR{LkWwPFch|ryP M4DodnNCVkeHUh?=
SF539 M{PWcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPVTWM2OD12Mj61OVI6KM7:TR?= NHK4TpZUSU6JRWK=
ESS-1 NXnvSWkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTR|LkW1OVgh|ryP MoHIV2FPT0WU
RO82-W-1 MmCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHqTWM2OD12Mz62NVU{KM7:TR?= NGqwUY9USU6JRWK=
S-117 Mn3PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzKWIZKSzVyPUSzMlY6PThizszN NXTMO|FlW0GQR1XS
SW756 NH\OTWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\5TWM2OD12Mz64NlQzKM7:TR?= NFHTdGdUSU6JRWK=
CP66-MEL NXHBfXJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIS4TI1KSzVyPUS1MlcyPDNizszN M4\1OXNCVkeHUh?=
H-EMC-SS MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTR3Lke2PVMh|ryP MkH0V2FPT0WU
NCI-H2052 NWjoTJFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTR3LkmwNlch|ryP M4DVbnNCVkeHUh?=
SW684 M{DRZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXWzV2pqUUN3ME20O{4xODhzIN88US=> MoXYV2FPT0WU
HCC1569 NVTjdpJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfxTWM2OD12Nz6xOlU5KM7:TR?= MYXTRW5ITVJ?
KGN M{\ScGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTR5LkOzNVEh|ryP MUTTRW5ITVJ?
LCLC-103H NYPlUIw2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkW3TWM2OD12Nz60OFA1KM7:TR?= MYDTRW5ITVJ?
SW780 M1\tSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPaUJhKSzVyPUS3MlY{PTFizszN M2XWZnNCVkeHUh?=
NCI-H1703 Ml\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTR6LkOzOVIh|ryP M4ThOXNCVkeHUh?=
HCC1395 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jpXWlEPTB;NEiuO|Q{OiEQvF2= NYrtepk5W0GQR1XS

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

体内試験 Gefitinib (100 mg/kg) improves the anti-tumor effect of radiotherapy in LoVo tumor xenografts. [3] Gefitinib treatment of nude mice bearing established human GEO colon cancer xenografts reveals a reversible dose-dependent inhibition of tumor growth because GEO tumors resumes the growth rate of controls at the end of the treatment. [4]

お薦めの試験操作(参考用のみ)

細胞試験: [1]
+ 展開
  • 細胞株: NR6, NR6M and NR6W cells
  • 濃度: 0-2 μM
  • 反応時間: 72 hours
  • 実験の流れ: Exponentially growing cells including NR6, NR6M, NR6M and NR6W cells are seeded in sextuple in 96-well plates at a concentration of 2000 cells/well, allowed to adhere and subsequently washed in PBS and incubated overnight in medium containing 0.5% FCS. Cells are then treated with varying concentrations (0-2 μM) of Gefitinib or the solute control DMSO and EGF. The optimal EGF concentration for inducing proliferation of NR6wtEGFR and NR6W cells has previously been determined and hence NR6wtEGFR and NR6W cells are supplemented with 10 nM and 0.1 nM EGF, respectively. EGF is not added to NR6 and NR6M cells. After 72 hours the amount of cells are measured by performing a MTT proliferation assay.
    (参考用のみ)
動物試験:[3]
+ 展開
  • 動物モデル: Female nude mice (cba nu/nu) aged 8–10 weeks are intra-dermal injected with LoVo cells.
  • 製剤: 0.5% polysorbate
  • 投薬量: 100 mg/kg
  • 投与方法: Once daily by oral administration (0.1 mL/10 g body weight) for 14 days
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 89 mg/mL (199.14 mM)
Ethanol 4 mg/mL (8.95 mM)
Water Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
1% CMC Na
混合させたのち直ちに使用することを推奨します。
30mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 446.90
化学式

C22H24ClFN4O3

CAS No. 184475-35-2
保管
in solvent
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03122717 Recruiting Non-Small Cell Lung Cancer Dana-Farber Cancer Institute|AstraZeneca May 9 2017 Phase 1
NCT00025675 Completed Brain and Central Nervous System Tumors Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|National Cancer Institute (NCI) October 9 2001 Phase 2
NCT03050164 Completed Bioequivalence Study Hunan Kelun Pharmaceutical Co. Ltd. September 8 2016 Phase 1
NCT01933347 Active not recruiting Non Small Cell Lung Cancer Guangdong Association of Clinical Trials April 7 2014 Phase 2
NCT03486496 Not yet recruiting Lung Adenocarcinoma|EGFR Mutation Fujian Cancer Hospital June 5 2018 Phase 2
NCT01610336 Active not recruiting Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis April 5 2012 Phase 2

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    I try to dissolve Gefitinib (ZD1839) in 0.5% methylcellulose+0.2% Tween 80 for in vivo experiments. However, when I prepare the mixture, it forms precipitates. Exists another way to dissolve completely the compound?

  • 回答:

    S1025 can be dissovled in both 5% DMSO+corn oil and 5% DMSO+30% PEG 300+5% Tween 80+ddH2O at 2.5 mg/ml clearly. It dissolves in DMSO not readily, please sonicate and warm it in water bath at about 45 degree, and dissolve it clearly first. Then add other solvent.

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