Gefitinib (ZD1839)

製品コードS1025

Gefitinib (ZD1839)化学構造

分子量(MW):446.90

Gefitinib (ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.

サイズ 価格(税別)  
JPY 31706.00
JPY 24402.00
JPY 44820.00

文献中Selleckの製品使用例(95)

カスタマーフィードバック(14)

  • c, HCC4006 lung cancer cells that have acquired a high-mesenchymal state concomitant with becoming resistant to gefitinib (red curve) exhibit increased sensitivity to GPX4 inhibition.

    Nature, 2017, 547(7664):453-457. Gefitinib (ZD1839) purchased from Selleck.

    Perturbation of EGFR by its ligand EGF and gefitinib (ZD-1839 Iressat; inhibits EGFR) produces opposite responses in the predicted EGFR target genes SOCS2 and NR2E1.

    Mol Syst Biol 2011 7, 486. Gefitinib (ZD1839) purchased from Selleck.

  • Effects of shRNA-mediated RECK depletion on EGFR signaling in MEFs. (a) Immunoblotting (IB) of the indicated proteins in wild-type MEFs transduced with the indicated shRNAs and cultured for 48 h in the presence of 0.1% dimethyl sulfoxide (DMSO; vehicle) or 1 mM gefitinib (S1025, Selleck Chemicals,Houston, TX, USA). (b) Immunoprecipitation from whole lysates of cells from panel a with an anti-phosphorylated tyrosine (pTyr) antibody. Precipitates from 500 mg protein in whole cell lysates (upper) or 20 mg protein in whole cell lysates (lower) were analyzed by IB with anti-EGFR antibody.

    Oncogene 2010 30, 737-750. Gefitinib (ZD1839) purchased from Selleck.

    (B–C) LNCaP (B) and LNCaP-AI (C) cells were transiently transfected with sPLA2-IIa(-800)-Luc (0.5 μg). The cells were then treated with Erlotinib (20 μM), Gefitinib (20 μM), Lapatinib (20 μM), CI-1033 (8 μM), LY294002 (20 lM) and Bortezomib (20 μM) without or with EGF (100 ng/ml) for 24 h. Luciferase assay was performed according to a standard protocol with Renilla luciferase as an internal control. Data are presented as the mean (±SD) of duplicate values of a representative experiment that was independently repeated for five times.

    Carcinogenesis 2010 31, 1948–1955 . Gefitinib (ZD1839) purchased from Selleck.

  • LNCaP-AI cells were starved in 1% stripped medium for 24 h. The cells were then treated with Erlotinib (20 μM), Gefitinib (20 μM), Lapatinib (20 μM), CI-1033 (8 μM), LY294002 (20 μM) and Bortezomib (20 μM) for 24 h. Cell culture medium was collected from each sample and subjected to ELISA for sPLA2-IIa. The condition medium samples were diluted 10 times for ELISA. Average of duplicate samples was converted to nanogram per milliliter against standard curve. The data represent one of five repeated experiments.

     

     

    Carcinogenesis 2010 31, 1948–1955. Gefitinib (ZD1839) purchased from Selleck.

    Suppression of EGFR signaling by Gefitinib is dose dependent and non- toxic at millimolar concentrations.Results from plaque reduction tests of Hep2 cells infected with VACV(12.5pfu/well) treated with a serial dilution of Gefitinib (1000-0.01 m) and analyzed for (A)proliferation as indicator of cytotoxicity,(B) IC50 of plaque size inhibition, (C)dose dependent inhibition of EGFR-ERK1/2signaling and VACV proteins by Western blot analysis (pEGFR detection was obtained from a different experiment with identicals ettings) and (D)dose dependent inhibition of orthopoxvirus genome replication by real-time PCR.Untreated VACV infectedcells and uninfected cells are shown as controls in the right panel.

    Antiviral Res 2010 89, 64-70. Gefitinib (ZD1839) purchased from Selleck.

  • A circular zone of EGFR activated but uninfected cells facilitate virus induced plaque development , efficiently blocked by Gefitinib. (A)Immun of luorescent staining of aplaque reduction tests with Hep2 cells 24,48,72 and 96 h after VACV infection (6.25pfu/chamber). VACV infected cells(green) were visualized by human IgG directed to orthopoxviruses (VIG) detected with a secondary FITC labelled antibody. Uninfected cells with activated EGFR signaling(red) are detected with a secondary Cy3labelled antibody. Positive cells for both , VACV and phosphorylated EGFR are shown in yellow(merge). Cellular nuclei are counterstained with DAPI. (B)Immunofluorescent staining of a plaque reduction test as described for (A) and treated with three different Gefitinib concentrations (1000 nM, 1 nM, and 0.01 nM) . The test was analyzed 96h afterVACV infection.Uninfected cells are shown as controls. Magnification100×.(For interpretation of the references to color in this figure legend , the reader is referred to the web version of the article.)

     

     

    Antiviral Res 2010 89, 64-70. Gefitinib (ZD1839) purchased from Selleck.

    Susceptibility of lung cancer cells to cytolytic activity of NK-92 cells after treatment with EGFR inhibitors. Three lung cancer cells were untreated (open circle) or treated with 10 μM erlotinib or gefitinib (black filled square or black filled triangle) for 24 hours. The lung cancer cells were cocultured with NK-92 cells at indicated effector to target ratio (E:T ratio). To determine the specificity of NKG2D-mediated cytolysis of lung cancer cells, NK-92 cells were preincubated with blocking mAb against NKG2D before the assay (gray filled square and triangle) and correspond-ing isotype mAb (open square and triangle).

    J Immunother 2011 34(4), 372-81. Gefitinib (ZD1839) purchased from Selleck.

  • Inhibition of 5-HT-induced 5-HT3A and 5-HT3AB receptor currents.

    Eur J Pharmacol, 2017, 821:21-28. Gefitinib (ZD1839) purchased from Selleck.

    The EGF-dependent increased association of PCM1 and AZI1 requires EGFR kinase activity. ZD1839 (Iressa)—EGFR tyrosine kinase inhibitor.

    Mol Biosyst 2011 7, 3223-33. Gefitinib (ZD1839) purchased from Selleck.

  • Reduction of GPER expression in HCC1806 cells after treatment with gefitinib. (A) Concentration dependence. HCC1806 cells were treated with 50-500 nM gefitinib for 48 h. GPER was detected by western blotting. (B) Time dependence. HCC1806 cells were treated with 200 nM gefitinib for 24-96 h. ap<0.05 vs. control; bp<0.001 vs. control. Mean values and SE of three independent experiments are shown. (C) Representative western blotting of concentration dependence. (D) Representative western blotting of time dependence

    Oncol Rep, 2017, 37(2):1212-1218. Gefitinib (ZD1839) purchased from Selleck.

    Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 215496. Gefitinib (ZD1839) purchased from Selleck.

  • Breast cancer cells were pretreated with 100ng/ml EGF for 15 min and then treated with the indicated concentrations of  Gefitinib for 24 hours.

     

     

    2010 Dr. Zhang of Tianjin Medical University. Gefitinib (ZD1839) purchased from Selleck.

    MTT assay result. 0-500nM Gefitinib treated with H1299, H358, H25 and HCC827 cell lines by 72h, Proliferation rate was tested.

     

     

    2010 Dr. Vicky Tin from University of Hong Kong. Gefitinib (ZD1839) purchased from Selleck.

製品安全説明書

EGFR阻害剤の選択性比較

生物活性

製品説明 Gefitinib (ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.
特性 A potent EGFR tyrosine kinase inhibitor.
ターゲット
Tyr1173 (NR6W cells) [1] Tyr1173 (NR6wtEGFR cells) [1] Tyr992 (NR6wtEGFR cells) [1] Tyr992 (NR6W cells) [1]
26 nM 37 nM 37 nM 57 nM
体外試験

Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low-EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition. Gefitinib effectively blocks the phosphorylation of PLC-γ, with IC50 of 27nM, in NR6W cells. The NR6wtEGFR and NR6M cell lines has low levels of PLC-γ phosphorylation but the level in the NR6M cell line is more resistant to inhibition by Gefitinib with IC50 of 43 nM and 369 nM, respectively. Gefitinib inhibits Akt phosphorylations, with IC50 of 220 and 263nM, in the low-EGFR- and -EGFRvIII-expressing cell lines, respectively. Gefitinib in the dose range from 0.1 to 0.5μM significantly facilitates, rather than abrogates, colony formation of NR6M cells. However, at a concentration of 2 μM Gefitinib completely blocks NR6M colony formation. Gefitinib rapidly and in a dose-dependent manner inhibits EGFR and ERK phosphorylation up to 72 hours after EGF stimulation in both the high- and low-EGFR-expressing cell lines. [1] Gefitinib is the monolayer growth of these EGF-driven untransformed MCF10A cells with an IC50 of 20 nM. [2] The combination of Gefitinib (0.2 μM and 0.5 μM) with irradiation lead to a significant growth inhibition in LoVo cells, compared with radiation alone.. [3]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KB MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEP1cFRKSzVyPUCuNFU1KM7:TR?= NYjxTpd5OTZ3MU[0O|M>
NIH3T3 MnflSpVv[3Srb36gRZN{[Xl? M3HqUVAvOiEQvF2= M4jWelIhcA>? MkW2SG1UVw>? M{LBOmlvcGmkaYTpc44hd2ZiRVfGJJN1cW23bHH0[YQhcHWvYX6g[ZJjSjFiYYX0c5Bpd3OyaH;yfYxifGmxbjD3bZRpKEmFNUCgc4YhOC5yMUS0JO69VQ>? Mn3qNVY1QDB{OES=
COS7 NIK2dINHfW6ldHnvckBCe3OjeR?= MlS2PVYh|ryP MkHMTY5pcWKrdHnvckBw\iCqdX3hckBLSUt{IG[2NVdHKG23dHHueEBmgHC{ZYPz[YQ> M17UbVE4OTd6N{Ky
A549 NGPE[WNEgXSxdH;4bYMhSXO|YYm= Ml;BPVYhcA>? NHHteW1FVVOR NWrQdY5UUUN3ME2xN{42QSEQvF2= MUKxPFMyOzhyNx?=
K562 MVvDfZRwfG:6aXOgRZN{[Xl? NUTYeGdjQTZiaB?= NUW1SnlsTE2VTx?= Mn;1TWM2OD17LkO2JO69VQ>? NYfMeGR{OTh|MUO4NFc>
MDA-MB-231 MUjDfZRwfG:6aXOgRZN{[Xl? MXG5OkBp NXjCe3J1TE2VTx?= MnTJTWM2OD1|Nj62NUDPxE1? M1WweVE5OzF|OEC3
MOLT4 NXm2dHNKS3m2b4TvfIlkKEG|c3H5 NELlUW06PiCq NEfzfWRFVVOR MnX0TWM2OD1zNT6wNkDPxE1? NX3mbpo{OTh|MUO4NFc>
MCF7 MX3DfZRwfG:6aXOgRZN{[Xl? MmHlOVAh|ryP MkXpO|IhcA>? NHPEZmFKSzVyPUGyMlA2KM7:TR?= Mn33NVg4PzF6MUm=
BT474 NF3GXVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Txc|czKGh? NWPYbmVzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDCWFQ4PCClZXzsd{BwfmW{ZYjwdoV{e2mwZzDFVmJjOiC5aYToJGVEPTBib3[gNE4{KM7:TR?= NXzs[5IxOTlyMki0NlQ>
HN5 NHH6d5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPiO|IhcA>? M{LxWmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSF61JINmdGy|IH;2[ZJmgHC{ZYPzbY5oKEWJRmKge4l1cCCHQ{WwJI9nKDBwMEGg{txO MVuxPVAzQDR{NB?=
BA/F3 M4H4eWN6fG:2b4jpZ{BCe3OjeR?= NFq3U|A4OiCq MnXsR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgRmEwTjNiY3XscJMh\XiycnXzd4lv\yCHR1\SJGw5PTiUIH31eIFvfCC5aYToJGlEPTBib3[gNE4xOTB6IN88US=> MUWxPVI{QTJ{OR?=
NIH3T3 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUK0eYdEPzJiaB?= MXLHdo94fGhiaX7obYJqfGmxbjDv[kBud3W|ZTDOTWgwO1R|IHPlcIx{KGW6cILld5NqdmdiZYLCNkBo\W6nIIfpeIghUUN3MDDv[kAxNjV2IN88US=> M4nZflE6PjZ3M{e3
MCF7 MX MXLGeY5kfGmxbjDBd5NigQ>? NEnLSpM{OCCvaX6= NEj3ZpVKdmirYnn0bY9vKG:oIFLDVnAh\XiycnXzd4VlKHerdHigTWM2OCCxZjCxMlEh|ryP NHniW|UyQTl|Mkm2NC=>
A431 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV2xNEDPxE1? M2mxVlczKGh? MYjHTVUxRTBwNUG0JO69VQ>? MWKxPVk3QTR4NR?=
A431 NGPVfYZMcW6jc3WgRZN{[Xl? NFLGN|cxNjFizszN M1rrZlEhcA>? NFPSO4JKdmirYnn0bY9vKG:oIFXHSk1qdmS3Y3XkJGVITlJicHjvd5Bpd3K7bHH0bY9v NETweHcyQTl4OUS2OS=>
A431 Mn2yT4lv[XOnIFHzd4F6 M3\0O|ExOCEQvF2= MmnjNVAhdWmw M1TtUnBzd2yxbnfl[EBqdmirYnn0c5J6KGGldHn2bZR6KG:oIFXHSk1qdmS3Y3XkJGVITlJicHjvd5Bpd3K7bHH0bY9v MWmxPVk3QTR4NR?=
Sf9 MW\LbY5ie2ViQYPzZZk> MlG2NVAhdWmw MomxSG1UVw>? NV\2b4VTUW6qaXLpeIlwdiCxZjDFS2ZTKGW6cILld5Nm\CCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHKnY3XweI9zKGG3dH;wbI9{eGixconsZZRqd25id3n0bEBKSzVyIH;mJFAvODN|IN88US=> NIf5ZpczODB3NkSyOS=>
NCI-H1975 M1vWUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmL3OUDPxE1? NEXRbVg4OiCq NXjzXW44UUN3ME24MlI3KM7:TR?= NWLK[mV4OjBzNUG2O|A>
NCI-H1975 MmPPT4lv[XOnIFHzd4F6 M{nkVlExKM7:TR?= M1G2[2lvcGmkaYTpc44hd2ZiRVfGVkBifXSxcHjvd5Bpd3K7bHH0bY9v M33NfVIxOTVzNkew
NCI-H1975 MVzGeY5kfGmxbjDBd5NigQ>? MUixNEDPxE1? M37Rc2lvcGmkaYTpc44hd2ZiRWLCRlIh[XW2b4Doc5NxcG:{eXzheIlwdg>? MmjaNlAyPTF4N{C=
NCI-H1975 NXXvZ2NyTnWwY4Tpc44hSXO|YYm= NWG5bowyPSEQvF2= M3nKZ|Q5KGh? MnvWTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCjc4Pld5Nm\CCjczDhZ5RqfmG2aX;uJI9nKGOjc4Dhd4UuOw>? M2DwOlIxOTVzNkew
A375 Mlq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEOzRmw1QCCq NHm5e2pKSzVyPUKwMlU2KM7:TR?= M1jzR|IxOzB2NUO3
SMMC7721 NIe2dYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVm0PEBp MUTJR|UxRTN|LkGyJO69VQ>? M4H2XlIxOzB2NUO3
DU145 NVnGV4J{S3m2b4TvfIlkKEG|c3H5 M4KxVVUh\A>? NWfvXFdjTE2VTx?= M1Xy[GlEPTB;NEKuNVch|ryP MlX4NlA1PjZ3NUW=
MIAPaCa2 MnTvR5l1d3SxeHnjJGF{e2G7 Mn7nOUBl MYfEUXNQ M4[xRmlEPTB;NUCuOlIh|ryP M4DaNFIxPDZ4NUW1
PANC1 MlvBR5l1d3SxeHnjJGF{e2G7 MoLnOUBl NV7HVnVTTE2VTx?= M3:3fmlEPTB;NECuOFIh|ryP NUjEOmFJOjB2Nk[1OVU>
PC9 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLTe3RCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGVITlJvZHXmbYNq\W62IHj1cYFvKFCFOTDj[YxteyC5aYToJGVEPTBib3[gNE4xOTdizszN NWXxWm1TOjF{MEi4NFI>
PC9 NU\RWWs4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnzXZZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIdzd3e2aD3y[ZNqe3SjboSgbJVu[W5iUFO5JINmdGy|IHX4dJJme3OrbnegSWdHWiCHN{S2Y2E4PTBxVEe5NG0hdXW2YX70JJdqfGhiRVO1NEBw\iB5IN88US=> MmjPNlEzODh6MEK=
PC3 NWHN[odZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYGxNEDPxE1? MmrLO|IhcA>? MUHEUXNQ NX3OPFVsUUN3ME23MlQh|ryP MVeyNVM2OzV2Nh?=
MDA-MB-468 NH7TfWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXixNFAh|ryP M3;BdlQ5KGh? MnvqSG1UVw>? Mkn3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdIm= M{LEfVIyPDJ7NkOy
Plasmodium falciparum NEXvfG5yUFSVIIDyc4ZqdGmwZzDmc5IhcW6qaXLpeI9zeyCxZjDQcIF{dW:maYXtJIZidGOrcHHyeY0heHKxbHnm[ZJifGmxbh?= NITDRZYzOThzN{C0OS=>
NCI-H1993 NFnJSnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jDUFczKGh? M13HcmROW09? NVjS[IZXUUN3ME2wMlEh|ryP MmTLNlE6OTZ2M{O=
NCI-H292 Mk\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fPWFczKGh? NWnCXG57TE2VTx?= NWfSdo1kUUN3ME2wMlAzKM7:TR?= NGfkdlgzOTlzNkSzNy=>
A431 MkLHT4lv[XOnIFHzd4F6 NF3wNlQzKGh? NXL3Z3pqTE2VTx?= M3XCfGlvcGmkaYTpc44hd2ZiRVfGVkBxcG:|cHjvdplt[XSrb36gbY4hTUeILYP0bY12dGG2ZXSgbJVu[W5iQUSzNUB4cXSqIFnDOVAhd2ZiMD6wNFEh|ryP MkKzNlIyODFzM{K=
MCF7 NEDVS4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Hx[lExOMLizsznM41N NVLufHRKPDhiaB?= NXLrc3J[TE2VTx?= MYXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNib4\ldoV5eHKnc4PpcochTUeIUjDn[Y5mKHerdHigTWM2OCCxZjCxNk4xPSEQvF2= Mor6NlIyOTlzM{C=
BT474 M1jkUmN6fG:2b4jpZ{BCe3OjeR?= MmDSNVAh|ryP MWK0PEBp M4G0ZmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KHOncoXtMZN1[XK4ZXSgbJVu[W5iQmS0O|Qh[2WubIO= Ml\2NlIyOzh|MEi=
MCF7 MX;DfZRwfG:6aXOgRZN{[Xl? M37IN|ExKM7:TR?= MX60PEBp NWOzOXlsS3m2b4TvfIlkcXS7IHHnZYlve3Ric3XyeY0ue3Sjco\l[EBpfW2jbjDNR2Y4KGOnbHzzJI93\XJvZYjwdoV{e2mwZzDFdoJDOiClZXzsdy=> M2ixVFIzOTN6M{C4
HCC827 NUnofWVXU2mwYYPlJGF{e2G7 M1LHSVAvOTJ3IN88US=> Ml\CNlQhcA>? MVPEUXNQ M3\ObGlvcGmkaYTpc44hd2ZiRVfGVkBl\WxiRUe0Ok1CPzVyIH31eIFvfCC\MUC2PEBifXSxcHjvd5Bpd3K7bHH0bY9v NHi3bHczOjN|OUO0Ni=>
HCC827 NV3peZlmU2mwYYPlJGF{e2G7 NHvJT4YxNjF{NTFOwG0> MmrGNlQhcA>? NH\IdWZFVVOR M1HtemlvcGmkaYTpc44hd2ZiRVfGVkBl\WxiRUe0Ok1CPzVyIH31eIFvfC2vZXTpZZRm\CCHcnugdIhwe3Cqb4L5cIF1cW:w Ml:4NlI{Ozl|NEK=
HCC827 NHe2b4ZMcW6jc3WgRZN{[Xl? MlS1NE4yOjVizszN NYj3e2huOjRiaB?= MYjEUXNQ NH6xOnhKdmirYnn0bY9vKG:oIFXHSnIh\GWuIFW3OFYuSTd3MDDteZRidnRvbXXkbYF1\WRiQXv0JJBpd3OyaH;yfYxifGmxbh?= NHjpdGMzOjN|OUO0Ni=>
A431 M2X2WGtqdmG|ZTDBd5NigQ>? NF7XNI0yODBizszN NYXiVolzOzBibXnu NVuzdVZ5UW6qaXLpeIlwdiCxZjDFS2ZTKGSncnn2[YQh\nKxbTDoeY1idiCDNEOxJINmdGxibXXtZpJidmViYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCyb3z5MWdtfS2WeYKgdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAyNjB6IN88US=> M4XTXFIzPjl6N{iy
H460 M2XqTmN6fG:2b4jpZ{BCe3OjeR?= NH;T[Y04OiCq MnGyTWM2OD13LkW5JO69VQ>? M1;PeVIzPzJ5NES5
HT-29 MnvtR5l1d3SxeHnjJGF{e2G7 MWe3NkBp NYXUO2NDUUN3ME2zMlM3KM7:TR?= NHz4e2kzOjd{N{S0PS=>
SGC7901 NEjqO2dEgXSxdH;4bYMhSXO|YYm= NXrNdHd1PzJiaB?= NF\5fVRKSzVyPUGwMlI3KM7:TR?= NVLsS3hlOjJ5Mke0OFk>
A498 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrIOlJXSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOFk5KGOnbHzzJIV5eHKnc4PpcochTUeIUjDhcoQhW1KFIIfpeIghUUN3MDDv[kA5NjZizszN NXfPfZk3OjJ6MUi4OFg>
Calu3 MVzDfZRwfG:6aXOgRZN{[Xl? NFLURoYyOCEQvHevcWw> Mkm3O|IhcA>? MVXJR|UxRTFwNjFOwG0> NUDYdnNTOjNzMU[xOlg>
FADU NFK0WWJEgXSxdH;4bYMhSXO|YYm= NUe0R2g2OTBizsznM41N NXS0V5E6PzJiaB?= NVLmZ2ZLUUN3ME2wMlA2KM7:TR?= Mlj0NlMyOTZzNki=
HCC827 NVrPXpRWS3m2b4TvfIlkKEG|c3H5 NI[1ZpIyOCEQvHevcWw> M2HZTVczKGh? MVLJR|UxRTBwMECxOUDPxE1? MnrpNlMyOTZzNki=
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IGROV-1 NFLtUJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PQeGlEPTB;Mj6zNVI{PyEQvF2= M3\6fHNCVkeHUh?=
JVM-3 M{LVV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7hNoFuUUN3ME2yMlM1PjR|IN88US=> MoG1V2FPT0WU
NCI-H2170 MnjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPocXJKSzVyPUKuN|Q4QDNizszN NXXEbpBHW0GQR1XS
EW-18 NH\yd3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nXZ2lEPTB;Mj6zOVQ4OSEQvF2= M{i5O3NCVkeHUh?=
KU812 Mn\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\1TWM2OD1{LkO2O|c6KM7:TR?= NV3hR4ZVW0GQR1XS
NY MnPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\DT2lEPTB;Mj6zO|I4KM7:TR?= NX:5VI5xW0GQR1XS
HTC-C3 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LEdGlEPTB;Mj60NlI3PyEQvF2= NVHac2xoW0GQR1XS
CFPAC-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NViyTJRXUUN3ME2yMlQ{QDZ2IN88US=> NEi2OmRUSU6JRWK=
HH MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTDTWM2OD1{LkS5PFU1KM7:TR?= MkjSV2FPT0WU
MKN7 M2DKVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGe1SpNKSzVyPUKuOlI4PDhizszN M4jCNXNCVkeHUh?=
TE-8 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTJwNkO2OVMh|ryP Mn24V2FPT0WU
MC-IXC NEHLUpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXaTWM2OD1{Lk[0OFU{KM7:TR?= NXLoV|BlW0GQR1XS
DMS-79 NUnYOJlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIOzRW5KSzVyPUKuOlkzQDRizszN NFflSnBUSU6JRWK=
Detroit562 NWLBb25{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTjNVdiUUN3ME2yMlY6QDR3IN88US=> MXfTRW5ITVJ?
HuP-T4 M3;Dbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTJwN{K4NVgh|ryP MXTTRW5ITVJ?
QIMR-WIL NXvVcWc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml60TWM2OD1{Lke1PVUzKM7:TR?= NV7BcYtRW0GQR1XS
BB65-RCC MlOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fROmlEPTB;Mj64NFcyOyEQvF2= M374PHNCVkeHUh?=
PC-3 M{LMb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7qTWM2OD1{LkizN|E4KM7:TR?= MofpV2FPT0WU
OVCAR-3 NWm1T3dZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV74Zo1uUUN3ME2yMlg2PTl2IN88US=> MUPTRW5ITVJ?
KYSE-510 M4PkSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoP5TWM2OD1{Lki2O|g3KM7:TR?= M{HvZnNCVkeHUh?=
HC-1 Mnq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITwOmdKSzVyPUKuPVQxOTJizszN NXzndpV{W0GQR1XS
NCI-H1693 NYS1dmZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zZR2lEPTB;Mj65OVg6PyEQvF2= NFnmfIxUSU6JRWK=
DU-4475 NGrrfINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXe1fmlZUUN3ME2yMlk6ODV{IN88US=> M4H3dnNCVkeHUh?=
COLO-680N NEPvd4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHT0fGFKSzVyPUOuNFA1QTVizszN NEHQTnBUSU6JRWK=
MN-60 MkPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHXTWM2OD1|LkC0PVc1KM7:TR?= MX7TRW5ITVJ?
BCPAP NHfSPYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;XNWlEPTB;Mz6wPFI6PSEQvF2= NUHD[JNrW0GQR1XS
647-V NU\IU5l3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDTTWM2OD1|LkG2NlIh|ryP NH7hOHBUSU6JRWK=
HT-1376 M{\keGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LKZ2lEPTB;Mz6yNFUxPiEQvF2= MWLTRW5ITVJ?
NCI-H1793 NGPpe4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYexN2p6UUN3ME2zMlIyODl6IN88US=> NEfYOYNUSU6JRWK=
SW1463 M{XteGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYe4cVFlUUN3ME2zMlI3OTl{IN88US=> MXvTRW5ITVJ?
NCI-H727 Mm\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjsTVBKSzVyPUOuN|g2QDRizszN MlLZV2FPT0WU
LB771-HNC NGWwbZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjmS|VtUUN3ME2zMlM6OTJ4IN88US=> MX3TRW5ITVJ?
D-542MG M37iN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTmTWM2OD1|LkS0NlIzKM7:TR?= NF7UbVFUSU6JRWK=
NTERA-S-cl-D1 Mm\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17jOGlEPTB;Mz60OFk2PyEQvF2= MVPTRW5ITVJ?
C8166 NH3CU29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nrUWlEPTB;Mz60OlUzOSEQvF2= NFPnS|VUSU6JRWK=
639-V MmTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fQXmlEPTB;Mz61O|c6OiEQvF2= MXzTRW5ITVJ?
TE-1 MlKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTNwNUmxOlkh|ryP MVjTRW5ITVJ?
OAW-28 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTQfXN4UUN3ME2zMlU6PDJ4IN88US=> M4rnPXNCVkeHUh?=
SK-LU-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLOTWM2OD1|Lk[wOlQ2KM7:TR?= NXLWWYRiW0GQR1XS
CaR-1 M1S2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTNwNkGwOFgh|ryP M3\ienNCVkeHUh?=
A2780 NUe5PZRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLrPZR1UUN3ME2zMlY1ODh7IN88US=> M3f0[XNCVkeHUh?=
C2BBe1 MlS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3PTWM2OD1|Lk[0OFA4KM7:TR?= M4jaWHNCVkeHUh?=
SK-MES-1 MnTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXryOpJkUUN3ME2zMlY1PjF2IN88US=> MnewV2FPT0WU
PANC-10-05 NIjKdYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzaOVB7UUN3ME2zMlczODd{IN88US=> MX3TRW5ITVJ?
J-RT3-T3-5 NVLlWYNDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIG1TXdKSzVyPUOuO|U1ODZizszN MXnTRW5ITVJ?
ES4 M2PhVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPqe2p3UUN3ME2zMlgzOjh4IN88US=> M1zzN3NCVkeHUh?=
NCI-H28 NInudGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TPfWlEPTB;Mz64Nlk3OSEQvF2= MlKxV2FPT0WU
NCI-H1155 NXP3UXRXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;QXFZ[UUN3ME2zMlg1OTV7IN88US=> MVTTRW5ITVJ?
KURAMOCHI MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTHTWM2OD1|Lki2NFU3KM7:TR?= MonpV2FPT0WU
NCI-H69 NFHqPItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTNwOUCxO|gh|ryP NU\PZYtYW0GQR1XS
IST-MES1 MoX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjYWphKSzVyPUOuPVQxOjlizszN NGXoNnRUSU6JRWK=
NH-12 NFnWdYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzITWM2OD1|Lkm0NVg4KM7:TR?= NXTod445W0GQR1XS
JVM-2 M33FWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfEfnFKSzVyPUOuPVQ4PTJizszN NIDKW3NUSU6JRWK=
EW-16 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfkTWM2OD1|Lkm1OVc4KM7:TR?= M{\5Z3NCVkeHUh?=
NCI-H441 MnfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LUU2lEPTB;Mz65O|AyPCEQvF2= NX6xd5RJW0GQR1XS
RCC10RGB MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPONoFKSzVyPUSuNFEzPDZizszN MkK0V2FPT0WU
TCCSUP MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTRwMUGwOUDPxE1? NYH0boxNW0GQR1XS
HL-60 NXjre5BZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEX2NXlKSzVyPUSuNVIzPDFizszN NWXndId3W0GQR1XS
EW-11 MnfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\WUo9KSzVyPUSuNVMzPjFizszN NGTQUmZUSU6JRWK=
KARPAS-299 NX;6OmhwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFe1RYNKSzVyPUSuN|ExOTNizszN NWTYZ|B7W0GQR1XS
SNU-C2B MlrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXvRWNKSzVyPUSuN|Q3QDZizszN MmO0V2FPT0WU
LU-139 MkXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHaTWM2OD12LkO3NlQ4KM7:TR?= MYLTRW5ITVJ?
HCC1937 MnK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXaO5dKSzVyPUSuN|c6QTNizszN M3K0NnNCVkeHUh?=
GR-ST NFjGU3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTRwNEOxPEDPxE1? MYPTRW5ITVJ?
SK-OV-3 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDTTItKSzVyPUSuOFYxPDJizszN M4D2ZnNCVkeHUh?=
A172 M2Hy[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTRwNUW1NlEh|ryP M1nnenNCVkeHUh?=
NB10 NWe0SY1IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTRwNUm3PFEh|ryP M3P6b3NCVkeHUh?=
P30-OHK NUPicZNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLiTWM2OD12LkixPVI6KM7:TR?= NULzbJF1W0GQR1XS
KYSE-520 MofaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nST2lEPTB;ND64PFAyQCEQvF2= M4TMeHNCVkeHUh?=
KNS-62 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTRwOUC4NFch|ryP NH:5UnRUSU6JRWK=
ES1 MmPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml20TWM2OD12Lkm2NFM2KM7:TR?= MVvTRW5ITVJ?
KOSC-2 NF\k[HlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTRwOUm5OVkh|ryP MYTTRW5ITVJ?
TE-9 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTVwMEG1NlUh|ryP MkPlV2FPT0WU
NCI-H1838 NGPkXmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnniTWM2OD13LkCyNFc3KM7:TR?= MkfrV2FPT0WU
KP-N-YN MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTVwMUK1PVEh|ryP MnXQV2FPT0WU
ALL-PO NGHYTYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV:4d3hiUUN3ME21MlIzPTh5IN88US=> M1LxVHNCVkeHUh?=
NOMO-1 M{fQNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DtTGlEPTB;NT6yN|E4PiEQvF2= MXHTRW5ITVJ?
CGTH-W-1 NYDzNHo3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1uxdmlEPTB;NT6zPFU5PCEQvF2= M{nlRXNCVkeHUh?=
ATN-1 NYOyWZR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXpU45KSzVyPUWuOFEyQDRizszN NXiwW3d7W0GQR1XS
AGS NXPPeXpJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTVwNEm2NVgh|ryP Mn3HV2FPT0WU
SW13 NVTzcmVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;MOmlEPTB;NT61N|I3PSEQvF2= NHvNO5BUSU6JRWK=
SW1990 MkPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDyTFhKSzVyPUWuOlIzQDVizszN MUDTRW5ITVJ?
BFTC-905 M37hNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTVwNkW4O|gh|ryP NF70WVRUSU6JRWK=
RMG-I MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LafGlEPTB;NT62OVk1OiEQvF2= Mmm2V2FPT0WU
HD-MY-Z NGLPVGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHDTWM2OD13Lk[4OVgyKM7:TR?= NXLDR49iW0GQR1XS
HCC1187 NFfZfIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTVwN{GwN|Ih|ryP MkmxV2FPT0WU
HCC2998 NIjVcWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIeyeWdKSzVyPUWuO|E5PzdizszN NH7RPFdUSU6JRWK=
RT-112 M1fIdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTVwOUCyOFUh|ryP M3TkeXNCVkeHUh?=
CAKI-1 NFHLWnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PFPWlEPTB;Nj6wNFk5PSEQvF2= MmLEV2FPT0WU
HDLM-2 Mmf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvsUJFzUUN3ME22MlAyPDh7IN88US=> NX65d2FqW0GQR1XS
TE-10 M{DQfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTZwMES4N|Mh|ryP MV\TRW5ITVJ?
KE-37 M3\1VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrEVXZOUUN3ME22MlA4OjV6IN88US=> MXfTRW5ITVJ?
RCM-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDzTWM2OD14LkC3O|E6KM7:TR?= NWSyV3hTW0GQR1XS
Mewo NV;YU4NYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DJZ2lEPTB;Nj6xNVQ5PyEQvF2= M3nsNHNCVkeHUh?=
L-428 NI\BUoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTYZ3VKSzVyPU[uNVgxOzdizszN Ml7DV2FPT0WU
8-MG-BA NWr3Xpp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTZwMUmzO|kh|ryP Mo\6V2FPT0WU
SK-MEL-28 NGT2VIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTZwMkC5Olch|ryP NVHubGhlW0GQR1XS
VA-ES-BJ NEPyepFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nKPWlEPTB;Nj6zNFQ3OiEQvF2= NYfUW5V5W0GQR1XS
CAL-120 NH;iOFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3:xVGlEPTB;Nj60OVE3OiEQvF2= M1i4b3NCVkeHUh?=
GAMG NEXGZ4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;yTWM2OD14LkWwOlIh|ryP NE[0S2pUSU6JRWK=
MSTO-221H NUnvRo5LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLzbVBKSzVyPU[uOVEyPyEQvF2= MVXTRW5ITVJ?
GCT MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jCOWlEPTB;Nj61N|M5PyEQvF2= NEfN[FJUSU6JRWK=
SH-4 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\2T3dmUUN3ME22MlU5QDR2IN88US=> Ml;IV2FPT0WU
Calu-3 M4rwe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4D2PWlEPTB;Nj62OVU3QCEQvF2= Mn:4V2FPT0WU
SK-HEP-1 M3;afWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33xRWlEPTB;Nj63NVc2OyEQvF2= MVjTRW5ITVJ?
PFSK-1 MkXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojWTWM2OD14LkezOFc5KM7:TR?= NWLaWZdlW0GQR1XS
NB12 NHHtUlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTZwN{i0NFQh|ryP MVHTRW5ITVJ?
A388 NGLnXotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLvTWM2OD14Lki5OVIh|ryP M{e1RXNCVkeHUh?=
KLE NHHqO4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV64SWVUUUN3ME22Mlk3PTF4IN88US=> NETqNpdUSU6JRWK=
TE-11 NVXUO49QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2S0cWlEPTB;Nz6wOFk3PyEQvF2= MXfTRW5ITVJ?
NCI-H2405 Mof2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTdwMEizPVMh|ryP NWjwdYZVW0GQR1XS
OVCAR-4 MmPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rzfGlEPTB;Nz6xOVM2KM7:TR?= NWHQT3pWW0GQR1XS
KP-N-YS M{LhTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTdwMUixOEDPxE1? M2PVSHNCVkeHUh?=
NOS-1 MnKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnT4TWM2OD15LkK1PFI5KM7:TR?= NW\mfXhbW0GQR1XS
DMS-114 NVzyVWpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3xTWM2OD15LkK5OlMyKM7:TR?= MVnTRW5ITVJ?
NCI-H2030 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3W4NGlEPTB;Nz6zN|Y6QCEQvF2= NGToZ4hUSU6JRWK=
HEL MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;tTWM2OD15LkO3OVIyKM7:TR?= NIPmcYdUSU6JRWK=
CAL-62 NFfKe4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTdwM{m4OlYh|ryP MkX0V2FPT0WU
COLO-668 NX;RZ3luT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVSzbYxYUUN3ME23MlQ{QTZ5IN88US=> M4PHfHNCVkeHUh?=
SKG-IIIa MknnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFuz[HBKSzVyPUeuOFU{QDFizszN M3rlN3NCVkeHUh?=
HCC1419 M2XiWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;nXXZmUUN3ME23MlQ3QDN|IN88US=> MUTTRW5ITVJ?
OS-RC-2 M3jzc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTdwNEm4PVQh|ryP Ml75V2FPT0WU
COLO-829 NIPBRlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTdwNk[0OlMh|ryP NX[5WINXW0GQR1XS
NB13 NXjXR4FIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEm0dmFKSzVyPUeuPFI3PjdizszN MnrXV2FPT0WU
DK-MG M2mwNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPWWoRHUUN3ME23Mlg{OjBzIN88US=> MmTmV2FPT0WU
SHP-77 M4DoSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTdwOE[2OVMh|ryP MmLHV2FPT0WU
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AM-38 M1rhd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXRTWM2OD16LkG2Nlgh|ryP MnX5V2FPT0WU
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5637 M4WyW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUP5R3RWUUN3ME24MlMyODV3IN88US=> NEHSNXRUSU6JRWK=
TGBC11TKB MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWW0XHFWUUN3ME24MlQ3OTZ2IN88US=> NFLLcXJUSU6JRWK=
EGI-1 M165NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3ixZmlEPTB;OD62NFA5QCEQvF2= MVnTRW5ITVJ?
D-392MG NGHS[ZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRThwNk[yNVQh|ryP MmrLV2FPT0WU
A673 M3;G[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRThwNke2NVEh|ryP Mkj5V2FPT0WU
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NCI-H1792 NInkOm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlm1TWM2OD16Lki4PVA{KM7:TR?= MX7TRW5ITVJ?
LS-1034 NGLtbFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjadGJJUUN3ME24Mlk1PjV{IN88US=> NYX5SZlbW0GQR1XS
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NCI-H226 NG\veWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXztZ2FiUUN3ME25MlA6KM7:TR?= NYL3NWxEW0GQR1XS
ChaGo-K-1 NGHYRopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDVTWM2OD17LkGwOVc6KM7:TR?= NWLhR4I2W0GQR1XS
NCI-H2228 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzh[GNKSzVyPUmuNVExQDFizszN MWTTRW5ITVJ?
RPMI-8226 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{S3TmlEPTB;OT6xNVMxPCEQvF2= NFjDWXNUSU6JRWK=
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HPAF-II NXexSW0zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\QcFUzUUN3ME25MlIzPTF6IN88US=> NFPIN3BUSU6JRWK=
Capan-2 Mn;NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWSzbnY5UUN3ME25MlQxOTB7IN88US=> Mn;vV2FPT0WU
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KP-4 NH\rc3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn6wTWM2OD17LkS4PFM5KM7:TR?= MnHBV2FPT0WU
A101D MkLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTlwNUG3NVkh|ryP NFLQ[HRUSU6JRWK=
EFO-21 MnjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTlwNUi3N|Uh|ryP MkC5V2FPT0WU
C32 MkXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXYelV6UUN3ME25MlY{OzRizszN MYDTRW5ITVJ?
SW837 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFT0UWNKSzVyPUmuPFQ5OiEQvF2= MWXTRW5ITVJ?
OCI-AML2 MmDTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PTWWlEPTB;OT64Olk3KM7:TR?= MlPBV2FPT0WU
NCI-H1355 Mki2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTlwOUSwPFgh|ryP MnO1V2FPT0WU
NCI-H2342 NFrsOIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nB[mlEPTB;MUCuNFE2PSEQvF2= MkGzV2FPT0WU
A204 M2PtW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXUPGFKSzVyPUGwMlA1PjZizszN NHz6[ItUSU6JRWK=
CAL-51 NFXXfnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHQfXl{UUN3ME2xNE4xQDd5IN88US=> NHXVSXpUSU6JRWK=
HCE-4 M324Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHZUXFjUUN3ME2xNE4yOTJ{IN88US=> NGDjeJNUSU6JRWK=
NCI-H810 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjGU3AyUUN3ME2xNE4yPTl5IN88US=> M4DpfXNCVkeHUh?=
DJM-1 Ml;CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzVRYt[UUN3ME2xNE4yPzN{IN88US=> M4rOV3NCVkeHUh?=
SK-UT-1 NIj4XoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPqXph3UUN3ME2xNE4zPTd2IN88US=> MVTTRW5ITVJ?
U031 NUjiWnFST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTFyLkK2PFYh|ryP MlvWV2FPT0WU
YH-13 M1z0Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnO[25PUUN3ME2xNE4{ODV5IN88US=> NILmVJBUSU6JRWK=
K5 NFLXO3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnDXlNWUUN3ME2xNE4{Ozl3IN88US=> Mn\BV2FPT0WU
HEC-1 M2PIb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUD6enFEUUN3ME2xNE41ODhzIN88US=> M37UNnNCVkeHUh?=
A2058 M13mc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTuSVRHUUN3ME2xNE42PDlzIN88US=> MlPjV2FPT0WU
SW962 M{mze2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFz6TWJKSzVyPUGwMlYzODRizszN Mon3V2FPT0WU
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D-336MG MlXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVKyZWo{UUN3ME2xNE44ODB3IN88US=> MoLpV2FPT0WU
LXF-289 NEDSSYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fWNGlEPTB;MUCuO|k3PyEQvF2= NGKxSo5USU6JRWK=
SW900 NWHONVk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rzfmlEPTB;MUCuPFIzQCEQvF2= NUXH[2gyW0GQR1XS
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SF-295 MkTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTFyLkm5NFIh|ryP M1HtWHNCVkeHUh?=
LB831-BLC NX62elh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHqzTJVKSzVyPUGxMlI2PTZizszN M1nMbXNCVkeHUh?=
FTC-133 NG\0[FJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTFzLkOwPFEh|ryP M4mxU3NCVkeHUh?=
HCC1954 NYfmSmlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3HTWM2OD1zMT60N|Yh|ryP MkC1V2FPT0WU
GOTO MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYD1S414UUN3ME2xNU42OjB4IN88US=> M1HYVnNCVkeHUh?=
LS-411N NGrlcFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTFzLk[xNFEh|ryP NV\PUJg6W0GQR1XS
RPMI-7951 M3\oVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTFzLk[zOFgh|ryP MUXTRW5ITVJ?
NCI-H1299 MmW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTYT|N5UUN3ME2xNU43PjR5IN88US=> M2\GcXNCVkeHUh?=
MLMA MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTFzLk[5PVch|ryP MUfTRW5ITVJ?
MMAC-SF M3PEUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTUOoFKSzVyPUGxMlczPTJizszN NF;5ZnNUSU6JRWK=
UM-UC-3 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknzTWM2OD1zMT63OFIyKM7:TR?= MWLTRW5ITVJ?
SCC-9 NV3U[IRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;mVoJKSzVyPUGxMlgyPTFizszN NUXTcppuW0GQR1XS
HOS Mk\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTFzLki2PFMh|ryP NWnMOXRTW0GQR1XS
OE19 M1;FZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTFzLkmzOlch|ryP MnPZV2FPT0WU
Mo-T NU\ReIpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTFzLkm1OFEh|ryP MWXTRW5ITVJ?
CAMA-1 NHzifJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXqS5dKSzVyPUGyMlE3OzNizszN M4rmUHNCVkeHUh?=
U-118-MG MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrIWVlKSzVyPUGyMlI1PDFizszN M3fRSnNCVkeHUh?=
KS-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPKNoQ2UUN3ME2xNk4zQDN{IN88US=> NWqzcGpvW0GQR1XS
JAR MkfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTF{LkOzOlkh|ryP M3m5cXNCVkeHUh?=
ABC-1 M3zLVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PNVGlEPTB;MUKuN|QyKM7:TR?= M{PINHNCVkeHUh?=
Daoy MlTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LkZ2lEPTB;MUKuOFU1OiEQvF2= Mn;VV2FPT0WU
C3A MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\WSWlEPTB;MUKuOVc5PSEQvF2= NIrJTYtUSU6JRWK=
GT3TKB Mn\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnm0TWM2OD1zMj62N|I4KM7:TR?= NXvYbVZwW0GQR1XS
DMS-273 NEHHeYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jCS2lEPTB;MUKuPFY{OyEQvF2= MYnTRW5ITVJ?
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RH-18 NWHycnp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTF|LkK5OlIh|ryP MoT3V2FPT0WU
SN12C MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7UTWM2OD1zMz6zPFA5KM7:TR?= MV7TRW5ITVJ?
NCI-H1993 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlroTWM2OD1zMz60Nlg2KM7:TR?= MVzTRW5ITVJ?
LOXIMVI M2[xVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PDT2lEPTB;MUOuOlE2OSEQvF2= MUDTRW5ITVJ?
SK-PN-DW NHzocotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn:wTWM2OD1zMz64OFI4KM7:TR?= MXTTRW5ITVJ?
KALS-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIf1SY5KSzVyPUGzMlg2OjVizszN MWLTRW5ITVJ?
LAN-6 NHH6RVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;1TWM2OD1zND6yOVMh|ryP NWPzV5BwW0GQR1XS
A549 NHjmd4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrCfXVKSzVyPUG0MlQ4OTJizszN M1HHd3NCVkeHUh?=
RD MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGraSZZKSzVyPUG0MlQ5OTNizszN NIj4T5dUSU6JRWK=
TGBC1TKB NX;0U3R[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEH5VWFKSzVyPUG0MlY3OTVizszN MVHTRW5ITVJ?
NCI-H630 NIH5RlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInLPXRKSzVyPUG0Mlk1PjdizszN MYrTRW5ITVJ?
MIA-PaCa-2 NEPQdJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\LVWlEPTB;MUSuPVY6KM7:TR?= MYfTRW5ITVJ?
NCI-H1755 M1nhZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XSeWlEPTB;MUSuPVk2OyEQvF2= MUTTRW5ITVJ?
MOLT-4 MoCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkGwTWM2OD1zNT6wOFk4KM7:TR?= MXHTRW5ITVJ?
CW-2 MnXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\jTmlEPTB;MUWuNVQzOSEQvF2= NYL2XnpyW0GQR1XS
COLO-320-HSR M2i0S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXhTWM2OD1zNT61N|A4KM7:TR?= M2WzcHNCVkeHUh?=
UMC-11 MnzrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPmeIR3UUN3ME2xOU44PTJ|IN88US=> Mmf3V2FPT0WU
MCF7 MlPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTF3LkixOFUh|ryP NWDTeWNYW0GQR1XS
NCI-H23 NIjxWpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jPZ2lEPTB;MUWuPFQ{QCEQvF2= MmHmV2FPT0WU
HuCCT1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfrTWM2OD1zNT64O|Qh|ryP NUHzdlVuW0GQR1XS
MPP-89 NXPNe|FPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTF3Lkm0NVch|ryP NVP6SXNSW0GQR1XS
HT55 M4LLVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jIUGlEPTB;MUWuPVQ4QCEQvF2= Mo\LV2FPT0WU
no-11 NYr4V5pRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkX4TWM2OD1zNT65OlY{KM7:TR?= M2TPWnNCVkeHUh?=
GP5d Ml\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXGd3JKSzVyPUG2MlIyQDdizszN M3q0TnNCVkeHUh?=
BHT-101 NYHpcYRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\lOIxKSzVyPUG2MlI1OzlizszN MVXTRW5ITVJ?
M059J M{\SWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnuzTWM2OD1zNj6yPFQh|ryP MoDNV2FPT0WU
D-283MED MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PPV2lEPTB;MU[uOFIxQSEQvF2= NXLHbHVYW0GQR1XS
BEN NX\F[mRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDhO2JKSzVyPUG2MlUyPTVizszN MlnSV2FPT0WU
LB373-MEL-D NIXSWpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzHTphXUUN3ME2xOk44OjN{IN88US=> MX\TRW5ITVJ?
MEL-HO NYjxOnlpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPqTWM2OD1zNj64PFU1KM7:TR?= NXnlcnpoW0GQR1XS
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NCI-H1573 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnqTWM2OD1zNz6yPFI3KM7:TR?= MX3TRW5ITVJ?
NCI-H1581 NHfWTW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4K5VmlEPTB;MUeuOFQyOSEQvF2= M{DUfXNCVkeHUh?=
NCI-H747 NUTue2tqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;xb2lEPTB;MUeuOVI6PyEQvF2= NYr3Z5JWW0GQR1XS
SW1783 NH\VWpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjoTWM2OD1zNz62OFE2KM7:TR?= M2TGbHNCVkeHUh?=
Calu-6 NE\sRpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTTfGxKSzVyPUG3MlY4QDJizszN MXLTRW5ITVJ?
SF268 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnztTWM2OD1zNz62PVY6KM7:TR?= NEThcHVUSU6JRWK=
ES8 NU[xSVA2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLQ[nBKSzVyPUG3Mlg2QTNizszN Ml3sV2FPT0WU
KM-H2 M4Sxcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LvZ2lEPTB;MUeuPVQyOSEQvF2= NVX1enh[W0GQR1XS
D-502MG MnSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVf3UZJSUUN3ME2xO{46QDB6IN88US=> MnryV2FPT0WU
HLE MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkX4TWM2OD1zOD6zNVQ5KM7:TR?= NFHWZXRUSU6JRWK=
SW982 M33ESmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVu1VYZ1UUN3ME2xPE41ODd3IN88US=> M2PXbHNCVkeHUh?=
MDA-MB-361 M4qzPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\T[WlEPTB;MUiuOVU5QCEQvF2= NFTrfVVUSU6JRWK=
NCI-H1563 M{nDNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrRZ5RKSzVyPUG4MlcyOjRizszN MUXTRW5ITVJ?
MFE-280 NVLITlU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXCbYNpUUN3ME2xPE44Ojl|IN88US=> MY\TRW5ITVJ?
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NB14 NWLJdXBYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HlZmlEPTB;M{iuOFU1PCEQvF2= NXryfoNqW0GQR1XS
D-423MG M1fSemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonqTWM2OD1|OD60PFY6KM7:TR?= NEL5fllUSU6JRWK=
NCI-H510A M13LeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rnZmlEPTB;M{iuOlQ2OSEQvF2= MWjTRW5ITVJ?
NMC-G1 NXjSXYZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HJOWlEPTB;M{iuO|IzOiEQvF2= NI\NUodUSU6JRWK=
SW948 MkXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTN6Lki5OFkh|ryP NEjpZnBUSU6JRWK=
MFM-223 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HORmlEPTB;M{iuPVQ{OSEQvF2= NWjWRXBYW0GQR1XS
PAN1 M1LqUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjxZVBUUUN3ME2zPE46QTF7IN88US=> NHTkWFVUSU6JRWK=
MZ7-mel M{i5XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTN7LkGxPVkh|ryP NXjkd5pkW0GQR1XS
COLO-679 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\iPJNKSzVyPUO5Mlk4ODhizszN MkntV2FPT0WU
SW872 NGXCfVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfjTWM2OD12MD6yNFMyKM7:TR?= MVzTRW5ITVJ?
HT-1197 M2iwdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3e1OmlEPTB;NECuNlg3QSEQvF2= MoTqV2FPT0WU
ES6 MmfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvXVVRKSzVyPUSwMlQ2PTJizszN NH[1bXhUSU6JRWK=
SNU-387 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7iTopKSzVyPUSwMlgzOzhizszN MVrTRW5ITVJ?
T47D M{i5XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXWTm5KSzVyPUSxMlAyQTJizszN MXjTRW5ITVJ?
G-402 NUjEZnpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYO4RYNPUUN3ME20NU4xQDB7IN88US=> MXXTRW5ITVJ?
MZ1-PC NIrNVJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1G2emlEPTB;NEGuPFEh|ryP MYrTRW5ITVJ?
SW1417 Mo\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXS2dXp{UUN3ME20Nk4{ODNizszN M2DUR3NCVkeHUh?=
RERF-LC-MS NH3nOo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jH[mlEPTB;NEKuOVA5PyEQvF2= NIfPVXFUSU6JRWK=
SF539 NVntVZhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTR{LkW1Nlkh|ryP NHXySGFUSU6JRWK=
ESS-1 NHntTGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XyNWlEPTB;NEOuOVU2QCEQvF2= MUPTRW5ITVJ?
RO82-W-1 MmqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTR|Lk[xOVMh|ryP MnPnV2FPT0WU
S-117 M2fLdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTR|Lk[5OVgh|ryP MW\TRW5ITVJ?
SW756 MmjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XMeGlEPTB;NEOuPFI1OiEQvF2= MYrTRW5ITVJ?
CP66-MEL M1fReGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjzWGs5UUN3ME20OU44OTR|IN88US=> M{XoZ3NCVkeHUh?=
H-EMC-SS MmjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTR3Lke2PVMh|ryP MVPTRW5ITVJ?
NCI-H2052 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVf0R|BJUUN3ME20OU46ODJ5IN88US=> MXnTRW5ITVJ?
SW684 Mki3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTR5LkCwPFEh|ryP MoHqV2FPT0WU
HCC1569 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXtXmxCUUN3ME20O{4yPjV6IN88US=> MWjTRW5ITVJ?
KGN MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjWWYJVUUN3ME20O{4{OzFzIN88US=> M4D4fHNCVkeHUh?=
LCLC-103H NIHFSHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37oPWlEPTB;NEeuOFQxPCEQvF2= MVTTRW5ITVJ?
SW780 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTR5Lk[zOVEh|ryP M1fGUnNCVkeHUh?=
NCI-H1703 MmTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jlfmlEPTB;NEiuN|M2OiEQvF2= MkP0V2FPT0WU
HCC1395 NXP6d|htT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3udYV4UUN3ME20PE44PDN{IN88US=> MmL2V2FPT0WU

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

体内試験 Gefitinib (100 mg/kg) improves the anti-tumor effect of radiotherapy in LoVo tumor xenografts. [3] Gefitinib treatment of nude mice bearing established human GEO colon cancer xenografts reveals a reversible dose-dependent inhibition of tumor growth because GEO tumors resumes the growth rate of controls at the end of the treatment. [4]

お薦めの試験操作(参考用のみ)

細胞試験: [1]
+ 展開
  • 細胞株: NR6, NR6M and NR6W cells
  • 濃度: 0-2 μM
  • 反応時間: 72 hours
  • 実験の流れ: Exponentially growing cells including NR6, NR6M, NR6M and NR6W cells are seeded in sextuple in 96-well plates at a concentration of 2000 cells/well, allowed to adhere and subsequently washed in PBS and incubated overnight in medium containing 0.5% FCS. Cells are then treated with varying concentrations (0-2 μM) of Gefitinib or the solute control DMSO and EGF. The optimal EGF concentration for inducing proliferation of NR6wtEGFR and NR6W cells has previously been determined and hence NR6wtEGFR and NR6W cells are supplemented with 10 nM and 0.1 nM EGF, respectively. EGF is not added to NR6 and NR6M cells. After 72 hours the amount of cells are measured by performing a MTT proliferation assay.
    (参考用のみ)
動物試験:[3]
+ 展開
  • 動物モデル: Female nude mice (cba nu/nu) aged 8–10 weeks are intra-dermal injected with LoVo cells.
  • 製剤: 0.5% polysorbate
  • 投薬量: 100 mg/kg
  • 投与方法: Once daily by oral administration (0.1 mL/10 g body weight) for 14 days
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 89 mg/mL (199.14 mM)
Ethanol 4 mg/mL (8.95 mM)
Water Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
1% CMC Na
混合させたのち直ちに使用することを推奨します。
30mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 446.90
化学式

C22H24ClFN4O3

CAS No. 184475-35-2
保管
in solvent
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03720873 Recruiting EGFR Gene Mutation Fujian Cancer Hospital October 2018 Phase 2
NCT03599518 Recruiting Non Small Cell Lung Cancer Daiichi Sankyo Co. Ltd.|Daiichi Sankyo Inc. October 10 2018 Phase 1
NCT03653546 Not yet recruiting Non-small Cell Lung Cancer|EGFR Gene Mutation|Brain Metastases Alpha Biopharma (Jiangsu) Co. Ltd. August 31 2018 Phase 2|Phase 3
NCT03602027 Not yet recruiting Non-squamous Non-small Cell Lung Cancer Second Affiliated Hospital of Nanchang University August 1 2018 Not Applicable
NCT03656393 Recruiting NSCLC|EGFR Shenzhen People''s Hospital August 31 2018 Phase 3
NCT03529084 Withdrawn Carcinoma Non-small Cell Lung Novartis Pharmaceuticals|Novartis July 23 2018 Phase 3

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    I try to dissolve Gefitinib (ZD1839) in 0.5% methylcellulose+0.2% Tween 80 for in vivo experiments. However, when I prepare the mixture, it forms precipitates. Exists another way to dissolve completely the compound?

  • 回答:

    S1025 can be dissovled in both 5% DMSO+corn oil and 5% DMSO+30% PEG 300+5% Tween 80+ddH2O at 2.5 mg/ml clearly. It dissolves in DMSO not readily, please sonicate and warm it in water bath at about 45 degree, and dissolve it clearly first. Then add other solvent.

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