Gefitinib (ZD1839)

製品コードS1025

Gefitinib (ZD1839)化学構造

分子量(MW):446.90

Gefitinib (ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.

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JPY 31706.00
JPY 24402.00
JPY 44820.00

文献中Selleckの製品使用例(95)

カスタマーフィードバック(14)

  • c, HCC4006 lung cancer cells that have acquired a high-mesenchymal state concomitant with becoming resistant to gefitinib (red curve) exhibit increased sensitivity to GPX4 inhibition.

    Nature, 2017, 547(7664):453-457. Gefitinib (ZD1839) purchased from Selleck.

    Perturbation of EGFR by its ligand EGF and gefitinib (ZD-1839 Iressat; inhibits EGFR) produces opposite responses in the predicted EGFR target genes SOCS2 and NR2E1.

    Mol Syst Biol 2011 7, 486. Gefitinib (ZD1839) purchased from Selleck.

  • Effects of shRNA-mediated RECK depletion on EGFR signaling in MEFs. (a) Immunoblotting (IB) of the indicated proteins in wild-type MEFs transduced with the indicated shRNAs and cultured for 48 h in the presence of 0.1% dimethyl sulfoxide (DMSO; vehicle) or 1 mM gefitinib (S1025, Selleck Chemicals,Houston, TX, USA). (b) Immunoprecipitation from whole lysates of cells from panel a with an anti-phosphorylated tyrosine (pTyr) antibody. Precipitates from 500 mg protein in whole cell lysates (upper) or 20 mg protein in whole cell lysates (lower) were analyzed by IB with anti-EGFR antibody.

    Oncogene 2010 30, 737-750. Gefitinib (ZD1839) purchased from Selleck.

    (B–C) LNCaP (B) and LNCaP-AI (C) cells were transiently transfected with sPLA2-IIa(-800)-Luc (0.5 μg). The cells were then treated with Erlotinib (20 μM), Gefitinib (20 μM), Lapatinib (20 μM), CI-1033 (8 μM), LY294002 (20 lM) and Bortezomib (20 μM) without or with EGF (100 ng/ml) for 24 h. Luciferase assay was performed according to a standard protocol with Renilla luciferase as an internal control. Data are presented as the mean (±SD) of duplicate values of a representative experiment that was independently repeated for five times.

    Carcinogenesis 2010 31, 1948–1955 . Gefitinib (ZD1839) purchased from Selleck.

  • LNCaP-AI cells were starved in 1% stripped medium for 24 h. The cells were then treated with Erlotinib (20 μM), Gefitinib (20 μM), Lapatinib (20 μM), CI-1033 (8 μM), LY294002 (20 μM) and Bortezomib (20 μM) for 24 h. Cell culture medium was collected from each sample and subjected to ELISA for sPLA2-IIa. The condition medium samples were diluted 10 times for ELISA. Average of duplicate samples was converted to nanogram per milliliter against standard curve. The data represent one of five repeated experiments.

     

     

    Carcinogenesis 2010 31, 1948–1955. Gefitinib (ZD1839) purchased from Selleck.

    Suppression of EGFR signaling by Gefitinib is dose dependent and non- toxic at millimolar concentrations.Results from plaque reduction tests of Hep2 cells infected with VACV(12.5pfu/well) treated with a serial dilution of Gefitinib (1000-0.01 m) and analyzed for (A)proliferation as indicator of cytotoxicity,(B) IC50 of plaque size inhibition, (C)dose dependent inhibition of EGFR-ERK1/2signaling and VACV proteins by Western blot analysis (pEGFR detection was obtained from a different experiment with identicals ettings) and (D)dose dependent inhibition of orthopoxvirus genome replication by real-time PCR.Untreated VACV infectedcells and uninfected cells are shown as controls in the right panel.

    Antiviral Res 2010 89, 64-70. Gefitinib (ZD1839) purchased from Selleck.

  • A circular zone of EGFR activated but uninfected cells facilitate virus induced plaque development , efficiently blocked by Gefitinib. (A)Immun of luorescent staining of aplaque reduction tests with Hep2 cells 24,48,72 and 96 h after VACV infection (6.25pfu/chamber). VACV infected cells(green) were visualized by human IgG directed to orthopoxviruses (VIG) detected with a secondary FITC labelled antibody. Uninfected cells with activated EGFR signaling(red) are detected with a secondary Cy3labelled antibody. Positive cells for both , VACV and phosphorylated EGFR are shown in yellow(merge). Cellular nuclei are counterstained with DAPI. (B)Immunofluorescent staining of a plaque reduction test as described for (A) and treated with three different Gefitinib concentrations (1000 nM, 1 nM, and 0.01 nM) . The test was analyzed 96h afterVACV infection.Uninfected cells are shown as controls. Magnification100×.(For interpretation of the references to color in this figure legend , the reader is referred to the web version of the article.)

     

     

    Antiviral Res 2010 89, 64-70. Gefitinib (ZD1839) purchased from Selleck.

    Susceptibility of lung cancer cells to cytolytic activity of NK-92 cells after treatment with EGFR inhibitors. Three lung cancer cells were untreated (open circle) or treated with 10 μM erlotinib or gefitinib (black filled square or black filled triangle) for 24 hours. The lung cancer cells were cocultured with NK-92 cells at indicated effector to target ratio (E:T ratio). To determine the specificity of NKG2D-mediated cytolysis of lung cancer cells, NK-92 cells were preincubated with blocking mAb against NKG2D before the assay (gray filled square and triangle) and correspond-ing isotype mAb (open square and triangle).

    J Immunother 2011 34(4), 372-81. Gefitinib (ZD1839) purchased from Selleck.

  • Inhibition of 5-HT-induced 5-HT3A and 5-HT3AB receptor currents.

    Eur J Pharmacol, 2017, 821:21-28. Gefitinib (ZD1839) purchased from Selleck.

    The EGF-dependent increased association of PCM1 and AZI1 requires EGFR kinase activity. ZD1839 (Iressa)—EGFR tyrosine kinase inhibitor.

    Mol Biosyst 2011 7, 3223-33. Gefitinib (ZD1839) purchased from Selleck.

  • Reduction of GPER expression in HCC1806 cells after treatment with gefitinib. (A) Concentration dependence. HCC1806 cells were treated with 50-500 nM gefitinib for 48 h. GPER was detected by western blotting. (B) Time dependence. HCC1806 cells were treated with 200 nM gefitinib for 24-96 h. ap<0.05 vs. control; bp<0.001 vs. control. Mean values and SE of three independent experiments are shown. (C) Representative western blotting of concentration dependence. (D) Representative western blotting of time dependence

    Oncol Rep, 2017, 37(2):1212-1218. Gefitinib (ZD1839) purchased from Selleck.

    Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 215496. Gefitinib (ZD1839) purchased from Selleck.

  • Breast cancer cells were pretreated with 100ng/ml EGF for 15 min and then treated with the indicated concentrations of  Gefitinib for 24 hours.

     

     

    2010 Dr. Zhang of Tianjin Medical University. Gefitinib (ZD1839) purchased from Selleck.

    MTT assay result. 0-500nM Gefitinib treated with H1299, H358, H25 and HCC827 cell lines by 72h, Proliferation rate was tested.

     

     

    2010 Dr. Vicky Tin from University of Hong Kong. Gefitinib (ZD1839) purchased from Selleck.

製品安全説明書

EGFR阻害剤の選択性比較

生物活性

製品説明 Gefitinib (ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.
特性 A potent EGFR tyrosine kinase inhibitor.
ターゲット
Tyr1173 (NR6W cells) [1] Tyr1173 (NR6wtEGFR cells) [1] Tyr992 (NR6wtEGFR cells) [1] Tyr992 (NR6W cells) [1]
26 nM 37 nM 37 nM 57 nM
体外試験

Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low-EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition. Gefitinib effectively blocks the phosphorylation of PLC-γ, with IC50 of 27nM, in NR6W cells. The NR6wtEGFR and NR6M cell lines has low levels of PLC-γ phosphorylation but the level in the NR6M cell line is more resistant to inhibition by Gefitinib with IC50 of 43 nM and 369 nM, respectively. Gefitinib inhibits Akt phosphorylations, with IC50 of 220 and 263nM, in the low-EGFR- and -EGFRvIII-expressing cell lines, respectively. Gefitinib in the dose range from 0.1 to 0.5μM significantly facilitates, rather than abrogates, colony formation of NR6M cells. However, at a concentration of 2 μM Gefitinib completely blocks NR6M colony formation. Gefitinib rapidly and in a dose-dependent manner inhibits EGFR and ERK phosphorylation up to 72 hours after EGF stimulation in both the high- and low-EGFR-expressing cell lines. [1] Gefitinib is the monolayer growth of these EGF-driven untransformed MCF10A cells with an IC50 of 20 nM. [2] The combination of Gefitinib (0.2 μM and 0.5 μM) with irradiation lead to a significant growth inhibition in LoVo cells, compared with radiation alone.. [3]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KB NXvWR5o3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInSbmdKSzVyPUCuNFU1KM7:TR?= M4PzUFE3PTF4NEez
NIH3T3 NHXyUZlHfW6ldHnvckBCe3OjeR?= MY[wMlIh|ryP Mm\UNkBp MV3EUXNQ MXLJcohq[mm2aX;uJI9nKEWJRjDzeIlufWyjdHXkJIh2dWGwIHXyZmIyKGG3dH;wbI9{eGixconsZZRqd25id3n0bEBKSzVyIH;mJFAvODF2NDFOwG0> MX[xOlQ5ODJ6NB?=
COS7 NITkSIpHfW6ldHnvckBCe3OjeR?= NETt[I46PiEQvF2= NVP6WpNsUW6qaXLpeIlwdiCxZjDoeY1idiCMQVuyJHY3OTeIIH31eIFvfCCneIDy[ZN{\WR? NHvvOHAyPzF5OEeyNi=>
A549 MnfKR5l1d3SxeHnjJGF{e2G7 M2TkfVk3KGh? MWPEUXNQ NXftRod{UUN3ME2xN{42QSEQvF2= NXrIRVViOTh|MUO4NFc>
K562 M4TyfWN6fG:2b4jpZ{BCe3OjeR?= NW\iNo96QTZiaB?= NIjvR2VFVVOR Mm[3TWM2OD17LkO2JO69VQ>? M{[4b|E5OzF|OEC3
MDA-MB-231 NIW1[HFEgXSxdH;4bYMhSXO|YYm= Mon2PVYhcA>? NHn6W4hFVVOR MnHyTWM2OD1|Nj62NUDPxE1? M37QZ|E5OzF|OEC3
MOLT4 NIXkSmtEgXSxdH;4bYMhSXO|YYm= M3nGT|k3KGh? M{ewcGROW09? MmLFTWM2OD1zNT6wNkDPxE1? NH;rVIIyQDNzM{iwOy=>
MCF7 Ml\BR5l1d3SxeHnjJGF{e2G7 NXTwUXR1PTBizszN NHLxZnA4OiCq MkLzTWM2OD1zMj6wOUDPxE1? MlGwNVg4PzF6MUm=
BT474 M1HD[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7TVm5YPzJiaB?= NETl[ZRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFLUOFc1KGOnbHzzJI93\XKneIDy[ZN{cW6pIFXSRoIzKHerdHigSWM2OCCxZjCwMlMh|ryP NWrXUYV[OTlyMki0NlQ>
HN5 MnLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF23WIg4OiCq NGnHco1CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjOOUBk\WyuczDveoVz\XiycnXzd4lv\yCHR1\SJJdqfGhiRVO1NEBw\iByLkCxJO69VQ>? M2H4XlE6ODJ6NEK0
BA/F3 NFHYZ4pEgXSxdH;4bYMhSXO|YYm= Mn;nO|IhcA>? MXvDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEWJRmKgUFg2QFJibYX0ZY51KHerdHigTWM2OCCxZjCwMlAyODhizszN M4OzNVE6OjN7MkK5
NIH3T3 M1XscWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HGOFczKGh? NG[xT4VIem:5dHigbY5pcWKrdHnvckBw\iCvb4Xz[UBPUUhxM2SzJINmdGy|IHX4dJJme3Orbneg[ZJDOiCpZX7lJJdqfGhiSVO1NEBw\iByLkW0JO69VQ>? M1XrUFE6PjZ3M{e3
MCF7 MX NITKVFlHfW6ldHnvckBCe3OjeR?= NGfyZlU{OCCvaX6= MUPJcohq[mm2aX;uJI9nKEKFUmCg[ZhxemW|c3XkJJdqfGhiSVO1NEBw\iBzLkGg{txO MYGxPVk{Ojl4MB?=
A431 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVOxNEDPxE1? MXO3NkBp NFmyfXVIUTVyPUCuOVE1KM7:TR?= NF\ZSmgyQTl4OUS2OS=>
A431 NHPMUHlMcW6jc3WgRZN{[Xl? MmP0NE4yKM7:TR?= M4LxclEhcA>? NXfhZVM1UW6qaXLpeIlwdiCxZjDFS2YucW6mdXPl[EBGT0[UIIDoc5NxcG:{eXzheIlwdg>? NGrYfJcyQTl4OUS2OS=>
A431 NX7KWWtJU2mwYYPlJGF{e2G7 MWOxNFAh|ryP MnHXNVAhdWmw M1rKcHBzd2yxbnfl[EBqdmirYnn0c5J6KGGldHn2bZR6KG:oIFXHSk1qdmS3Y3XkJGVITlJicHjvd5Bpd3K7bHH0bY9v NUPI[oM2OTl7Nkm0OlU>
Sf9 NYDFNWxnU2mwYYPlJGF{e2G7 MVuxNEBucW5? M1raVWROW09? Mlm3TY5pcWKrdHnvckBw\iCHR1\SJIV5eHKnc4Pl[EBie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJJm[2WydH;yJIF2fG:yaH;zdIhwenmuYYTpc44hf2m2aDDJR|UxKG:oIECuNFM{KM7:TR?= M17wb|IxODV4NEK1
NCI-H1975 NGH2eJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEX2VFg2KM7:TR?= M{P4TlczKGh? MmPQTWM2OD16LkK2JO69VQ>? M4DuclIxOTVzNkew
NCI-H1975 MojmT4lv[XOnIFHzd4F6 M1m5TVExKM7:TR?= MlWzTY5pcWKrdHnvckBw\iCHR1\SJIF2fG:yaH;zdIhwenmuYYTpc44> Ml76NlAyPTF4N{C=
NCI-H1975 M4T0OmZ2dmO2aX;uJGF{e2G7 MmSzNVAh|ryP NX7LVY5KUW6qaXLpeIlwdiCxZjDFVmJDOiCjdYTvdIhwe3Cqb4L5cIF1cW:w MXqyNFE2OTZ5MB?=
NCI-H1975 NGfjNItHfW6ldHnvckBCe3OjeR?= NIXyXlE2KM7:TR?= NIGyNog1QCCq MmK2TY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCjc4Pld5Nm\CCjczDhZ5RqfmG2aX;uJI9nKGOjc4Dhd4UuOw>? Mn;RNlAyPTF4N{C=
A375 NVnhbYVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDoWnUzPDhiaB?= NFHtNYZKSzVyPUKwMlU2KM7:TR?= MnjLNlA{ODR3M{e=
SMMC7721 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\oS3dpPDhiaB?= M{jDS2lEPTB;M{OuNVIh|ryP Mmq3NlA{ODR3M{e=
DU145 Mm\SR5l1d3SxeHnjJGF{e2G7 MkKzOUBl Ml7ISG1UVw>? NH\nPXBKSzVyPUSyMlE4KM7:TR?= Ml3rNlA1PjZ3NUW=
MIAPaCa2 NGfOc2dEgXSxdH;4bYMhSXO|YYm= MXS1JIQ> MWjEUXNQ MmC5TWM2OD13MD62NkDPxE1? NV3PUZhlOjB2Nk[1OVU>
PANC1 Mn3lR5l1d3SxeHnjJGF{e2G7 MontOUBl MXjEUXNQ NH3ze|VKSzVyPUSwMlQzKM7:TR?= MmXUNlA1PjZ3NUW=
PC9 NWnrV5hmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfQRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDFS2ZTNWSnZnnjbYVvfCCqdX3hckBRSzliY3XscJMhf2m2aDDFR|UxKG:oIECuNFE4KM7:TR?= NHy2U2MzOTJyOEiwNi=>
PC9 NHzzRYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm[zRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDndo94fGhvcnXzbZN1[W62IHj1cYFvKFCFOTDj[YxteyCneIDy[ZN{cW6pIFXHSnIhTTd2Nm;BO|UxN1R5OUDNJI12fGGwdDD3bZRpKEWFNUCgc4YhPyEQvF2= MVyyNVIxQDhyMh?=
PC3 M2LUdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLZfm1KOTBizszN MoKzO|IhcA>? MnfBSG1UVw>? NXKxdXBWUUN3ME23MlQh|ryP NFXO[nEzOTN3M{W0Oi=>
MDA-MB-468 MoPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrzNVAxKM7:TR?= MYC0PEBp MlnqSG1UVw>? M3;3PGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5 MWGyNVQzQTZ|Mh?=
Plasmodium falciparum NVzNbpJGeUiWUzDwdo9ncWyrbneg[o9zKGmwaHnibZRwenNib3[gVIxie22xZHn1cUBn[WylaYDhdpVuKHC{b3zp[oVz[XSrb36= MnTyNlE5OTdyNEW=
NCI-H1993 NYDPcpZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjOfHd6PzJiaB?= MXLEUXNQ NFvxNYJKSzVyPUCuNUDPxE1? NYXzbZpTOjF7MU[0N|M>
NCI-H292 NGjHTIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{O2ZVczKGh? M1\5[mROW09? MXvJR|UxRTBwMEKg{txO M1;PSlIyQTF4NEOz
A431 MYLLbY5ie2ViQYPzZZk> MXWyJIg> MlrpSG1UVw>? MX\Jcohq[mm2aX;uJI9nKEWJRmKgdIhwe3Cqb4L5cIF1cW:wIHnuJGVITi2|dHnteYxifGWmIHj1cYFvKEF2M{Gge4l1cCCLQ{WwJI9nKDBwMECxJO69VQ>? NHO5WWczOjFyMUGzNi=>
MCF7 MlP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LkdFExOMLizsznM41N MkPWOFghcA>? M1W5OWROW09? MnrWRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IH;2[ZJmgHC{ZYPzbY5oKEWJRmKg[4Vv\SC5aYToJGlEPTBib3[gNVIvODVizszN MWGyNlEyQTF|MB?=
BT474 NI\sW45EgXSxdH;4bYMhSXO|YYm= M13ZdVExKM7:TR?= MYW0PEBp M33FR2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KHOncoXtMZN1[XK4ZXSgbJVu[W5iQmS0O|Qh[2WubIO= MmGyNlIyOzh|MEi=
MCF7 NWHHOFVSS3m2b4TvfIlkKEG|c3H5 MVGxNEDPxE1? M13tfVQ5KGh? NYDJSFN7S3m2b4TvfIlkcXS7IHHnZYlve3Ric3XyeY0ue3Sjco\l[EBpfW2jbjDNR2Y4KGOnbHzzJI93\XJvZYjwdoV{e2mwZzDFdoJDOiClZXzsdy=> NXzKVXA5OjJzM{izNFg>
HCC827 NX\hRXZqU2mwYYPlJGF{e2G7 M3XQU|AvOTJ3IN88US=> NYXHfolROjRiaB?= M{LKRmROW09? NYHKOmtYUW6qaXLpeIlwdiCxZjDFS2ZTKGSnbDDFO|Q3NUF5NUCgcZV1[W62IGmxNFY5KGG3dH;wbI9{eGixconsZZRqd25? M3zlUVIzOzN7M{Sy
HCC827 NHHvd3hMcW6jc3WgRZN{[Xl? MX6wMlEzPSEQvF2= NHLjVFMzPCCq M{Pod2ROW09? Mn\WTY5pcWKrdHnvckBw\iCHR1\SJIRmdCCHN{S2MWE4PTBibYX0ZY51NW2nZHnheIVlKEW{azDwbI9{eGixconsZZRqd25? MoPzNlI{Ozl|NEK=
HCC827 NWj2NXJQU2mwYYPlJGF{e2G7 NXzpN|dMOC5zMkWg{txO M3PndlI1KGh? M3yze2ROW09? NF7rcGdKdmirYnn0bY9vKG:oIFXHSnIh\GWuIFW3OFYuSTd3MDDteZRidnRvbXXkbYF1\WRiQXv0JJBpd3OyaH;yfYxifGmxbh?= NVO2TYxbOjJ|M{mzOFI>
A431 M4rRVmtqdmG|ZTDBd5NigQ>? MmO3NVAxKM7:TR?= M2\xTVMxKG2rbh?= MVnJcohq[mm2aX;uJI9nKEWJRmKg[IVzcX[nZDDmdo9uKGi3bXHuJGE1OzFiY3XscEBu\W2kcnHu[UBie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJBwdHlvR3z1MXR6eiCyaH;zdIhwenmuYYTpc44hf2m2aDDJR|UxKG:oIEGuNFgh|ryP MorHNlI3QTh5OEK=
H460 NVm4PIZwS3m2b4TvfIlkKEG|c3H5 NHv1[XI4OiCq M4TyTGlEPTB;NT61PUDPxE1? NH62SGgzOjd{N{S0PS=>
HT-29 NXWwZYk6S3m2b4TvfIlkKEG|c3H5 MWW3NkBp NXu0XYVmUUN3ME2zMlM3KM7:TR?= NHzDRVQzOjd{N{S0PS=>
SGC7901 MXTDfZRwfG:6aXOgRZN{[Xl? MVK3NkBp NVPxV2RXUUN3ME2xNE4zPiEQvF2= MVqyNlczPzR2OR?=
A498 M4XO[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXQRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNEm4JINmdGy|IHX4dJJme3OrbnegSWdHWiCjbnSgV3JEKHerdHigTWM2OCCxZjC4MlYh|ryP M3\IUlIzQDF6OES4
Calu3 NHLBTVFEgXSxdH;4bYMhSXO|YYm= NHHGTmUyOCEQvHevcWw> NHrLU4U4OiCq MlXHTWM2OD1zLk[g{txO Mk\ONlMyOTZzNki=
FADU MYXDfZRwfG:6aXOgRZN{[Xl? MWqxNEDPxGdxbVy= MmnYO|IhcA>? MmDkTWM2OD1yLkC1JO69VQ>? NHTJXoUzOzFzNkG2PC=>
HCC827 NVPadI5tS3m2b4TvfIlkKEG|c3H5 MX2xNEDPxGdxbVy= M2HIW|czKGh? MmizTWM2OD1yLkCwNVUh|ryP NGHSRm0zOzFzNkG2PC=>
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IGROV-1 M3nxN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTJwM{GyN|ch|ryP MXvTRW5ITVJ?
JVM-3 NFTHfFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13T[GlEPTB;Mj6zOFY1OyEQvF2= M1TQ[nNCVkeHUh?=
NCI-H2170 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVWxeXJxUUN3ME2yMlM1Pzh|IN88US=> M3SwPHNCVkeHUh?=
EW-18 NV;SO5E5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHMcpZiUUN3ME2yMlM2PDdzIN88US=> NFWzO3ZUSU6JRWK=
KU812 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTJwM{[3O|kh|ryP NYjvOVVlW0GQR1XS
NY NX3OWmloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTJwM{eyO{DPxE1? Mmq4V2FPT0WU
HTC-C3 NHS3cWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFuzOpVKSzVyPUKuOFIzPjdizszN MXTTRW5ITVJ?
CFPAC-1 NHPxdJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTJwNEO4OlQh|ryP NE\qNY5USU6JRWK=
HH M3Xub2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3z4SGlEPTB;Mj60PVg2PCEQvF2= MmO0V2FPT0WU
MKN7 MlexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3q1emlEPTB;Mj62Nlc1QCEQvF2= MV3TRW5ITVJ?
TE-8 M3Lre2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HPXWlEPTB;Mj62N|Y2OyEQvF2= NVnTXJBSW0GQR1XS
MC-IXC M{nIR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUe0PFhHUUN3ME2yMlY1PDV|IN88US=> NUHV[mZHW0GQR1XS
DMS-79 MkLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfCTWM2OD1{Lk[5Nlg1KM7:TR?= MVfTRW5ITVJ?
Detroit562 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fNbGlEPTB;Mj62PVg1PSEQvF2= NHvZSWZUSU6JRWK=
HuP-T4 MnXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHu1W4FKSzVyPUKuO|I5OThizszN MXPTRW5ITVJ?
QIMR-WIL MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3S5T2lEPTB;Mj63OVk2OiEQvF2= NWLK[JoxW0GQR1XS
BB65-RCC M2O5TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LkbGlEPTB;Mj64NFcyOyEQvF2= MYTTRW5ITVJ?
PC-3 MlvvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTJwOEOzNVch|ryP MXfTRW5ITVJ?
OVCAR-3 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo[xTWM2OD1{Lki1OVk1KM7:TR?= NH\2XJZUSU6JRWK=
KYSE-510 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfXbJV5UUN3ME2yMlg3Pzh4IN88US=> NVzj[WJkW0GQR1XS
HC-1 MlXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrPVGx1UUN3ME2yMlk1ODF{IN88US=> MVLTRW5ITVJ?
NCI-H1693 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH70cYpKSzVyPUKuPVU5QTdizszN MonlV2FPT0WU
DU-4475 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2q2XGlEPTB;Mj65PVA2OiEQvF2= MYjTRW5ITVJ?
COLO-680N MlHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXkbZR3UUN3ME2zMlAxPDl3IN88US=> NGrDbWpUSU6JRWK=
MN-60 NUjRT4I6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvyVYJKSzVyPUOuNFQ6PzRizszN NUfZdGV1W0GQR1XS
BCPAP MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTnR2RKSzVyPUOuNFgzQTVizszN MUDTRW5ITVJ?
647-V NUm5Z3p3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjPd2dKSzVyPUOuNVYzOiEQvF2= NFr6bppUSU6JRWK=
HT-1376 NV\XdIQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjNN5dYUUN3ME2zMlIxPTB4IN88US=> MWnTRW5ITVJ?
NCI-H1793 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\QTo9oUUN3ME2zMlIyODl6IN88US=> MkLsV2FPT0WU
SW1463 M3PKTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXpPYJKSzVyPUOuNlYyQTJizszN M1XCd3NCVkeHUh?=
NCI-H727 NX[1eYw5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTNwM{i1PFQh|ryP M1PNV3NCVkeHUh?=
LB771-HNC NGHCZWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmK1TWM2OD1|LkO5NVI3KM7:TR?= M2q1cHNCVkeHUh?=
D-542MG MmjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmqwTWM2OD1|LkS0NlIzKM7:TR?= NGjkOZlUSU6JRWK=
NTERA-S-cl-D1 MluyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTNwNES5OVch|ryP NXH4VpEzW0GQR1XS
C8166 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVz2PJoxUUN3ME2zMlQ3PTJzIN88US=> NVi0eXVYW0GQR1XS
639-V MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PXOGlEPTB;Mz61O|c6OiEQvF2= M2XZV3NCVkeHUh?=
TE-1 NUDBbFZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXEe|lKSzVyPUOuOVkyPjlizszN MmK5V2FPT0WU
OAW-28 NFexT|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnTTWM2OD1|LkW5OFI3KM7:TR?= M{\leXNCVkeHUh?=
SK-LU-1 Ml\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkS2TWM2OD1|Lk[wOlQ2KM7:TR?= MUfTRW5ITVJ?
CaR-1 NHzBXnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTNwNkGwOFgh|ryP Mk[wV2FPT0WU
A2780 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTNwNkSwPFkh|ryP NUDOfoJjW0GQR1XS
C2BBe1 MnvuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnZTWM2OD1|Lk[0OFA4KM7:TR?= MnThV2FPT0WU
SK-MES-1 NEPXeW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETr[pRKSzVyPUOuOlQ3OTRizszN NXHsfWN1W0GQR1XS
PANC-10-05 MlW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jJPWlEPTB;Mz63NlA4OiEQvF2= M1HoRnNCVkeHUh?=
J-RT3-T3-5 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml63TWM2OD1|Lke1OFA3KM7:TR?= NEXVNXJUSU6JRWK=
ES4 NELBZmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvrUWxKSzVyPUOuPFIzQDZizszN NX3B[I0yW0GQR1XS
NCI-H28 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTNwOEK5OlEh|ryP M3XXfnNCVkeHUh?=
NCI-H1155 NF7Qe3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXr4NW9OUUN3ME2zMlg1OTV7IN88US=> NVX4W3N2W0GQR1XS
KURAMOCHI MmT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXSPGlKSzVyPUOuPFYxPTZizszN NImybJlUSU6JRWK=
NCI-H69 M1HIeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrPfVJKSzVyPUOuPVAyPzhizszN MmC2V2FPT0WU
IST-MES1 M4H4cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTNwOUSwNlkh|ryP MXnTRW5ITVJ?
NH-12 MkfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnK0TWM2OD1|Lkm0NVg4KM7:TR?= MXjTRW5ITVJ?
JVM-2 MnTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGO3PVBKSzVyPUOuPVQ4PTJizszN MkXHV2FPT0WU
EW-16 NVvZVIdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTNwOUW1O|ch|ryP Ml;wV2FPT0WU
NCI-H441 NVHMSXRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTNwOUewNVQh|ryP MUPTRW5ITVJ?
RCC10RGB M1n4O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjrTWM2OD12LkCxNlQ3KM7:TR?= NXfNWIlzW0GQR1XS
TCCSUP NU\sWnZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTRwMUGwOUDPxE1? NX7UPFE6W0GQR1XS
HL-60 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrGTWM2OD12LkGyNlQyKM7:TR?= M1zHfXNCVkeHUh?=
EW-11 NWj1enF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYixXVdzUUN3ME20MlE{OjZzIN88US=> NX;TUGdXW0GQR1XS
KARPAS-299 NXnydYN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\1TWM2OD12LkOxNFE{KM7:TR?= NXz0[HU4W0GQR1XS
SNU-C2B MoLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFuyPGFKSzVyPUSuN|Q3QDZizszN NG\KcnJUSU6JRWK=
LU-139 NY\KcGMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPtSoZSUUN3ME20MlM4OjR5IN88US=> NYrxSFJbW0GQR1XS
HCC1937 MnXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnjXJJKSzVyPUSuN|c6QTNizszN NHq4dZJUSU6JRWK=
GR-ST NUHzTW5KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jJXGlEPTB;ND60N|E5KM7:TR?= MkPFV2FPT0WU
SK-OV-3 NX;j[Jp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkKyTWM2OD12LkS2NFQzKM7:TR?= NHX3bGRUSU6JRWK=
A172 NHm4U4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPJd5RKSzVyPUSuOVU2OjFizszN MkfKV2FPT0WU
NB10 NV[1NVBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfu[XpKSzVyPUSuOVk4QDFizszN NEP5UpVUSU6JRWK=
P30-OHK M1;Kbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXyUG1NUUN3ME20MlgyQTJ7IN88US=> NFPlfYpUSU6JRWK=
KYSE-520 NXnIb2V5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTRwOEiwNVgh|ryP MVnTRW5ITVJ?
KNS-62 MlfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37IXGlEPTB;ND65NFgxPyEQvF2= M4TGSHNCVkeHUh?=
ES1 M4S2cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfyOJhyUUN3ME20Mlk3ODN3IN88US=> NYHwVG9LW0GQR1XS
KOSC-2 M1j4dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTRwOUm5OVkh|ryP MWXTRW5ITVJ?
TE-9 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUiwWoNbUUN3ME21MlAyPTJ3IN88US=> M334UXNCVkeHUh?=
NCI-H1838 NVfDO29OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTVwMEKwO|Yh|ryP NX:0OpJWW0GQR1XS
KP-N-YN NFrUcnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXoTWM2OD13LkGyOVkyKM7:TR?= MoTCV2FPT0WU
ALL-PO MnOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvqWHp1UUN3ME21MlIzPTh5IN88US=> M2TNZ3NCVkeHUh?=
NOMO-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnGTWM2OD13LkKzNVc3KM7:TR?= Mnf4V2FPT0WU
CGTH-W-1 NV[3bVBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGf4No9KSzVyPUWuN|g2QDRizszN M1z1SXNCVkeHUh?=
ATN-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXmZolGUUN3ME21MlQyOTh2IN88US=> NV\zNWFNW0GQR1XS
AGS M4DkV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTVwNEm2NVgh|ryP MXrTRW5ITVJ?
SW13 M{LHSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LVdWlEPTB;NT61N|I3PSEQvF2= NV3K[2RxW0GQR1XS
SW1990 MnzwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHwO5NKSzVyPUWuOlIzQDVizszN NEi1bZRUSU6JRWK=
BFTC-905 NGLLUodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWD4SZg1UUN3ME21MlY2QDd6IN88US=> NWTlfYluW0GQR1XS
RMG-I NWLVdVRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTVwNkW5OFIh|ryP MnzVV2FPT0WU
HD-MY-Z NIHrdGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fOSmlEPTB;NT62PFU5OSEQvF2= NYnHPW1mW0GQR1XS
HCC1187 MnXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTVwN{GwN|Ih|ryP NWLFR|RxW0GQR1XS
HCC2998 NHX0[FBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDO[WRYUUN3ME21MlcyQDd5IN88US=> MnLuV2FPT0WU
RT-112 MoPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jjcWlEPTB;NT65NFI1PSEQvF2= M4npWnNCVkeHUh?=
CAKI-1 MlLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\P[ldKSzVyPU[uNFA6QDVizszN MlTBV2FPT0WU
HDLM-2 MnTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDOTWM2OD14LkCxOFg6KM7:TR?= NHXK[IhUSU6JRWK=
TE-10 NEDnXIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PY[2lEPTB;Nj6wOFg{OyEQvF2= NF7UTYtUSU6JRWK=
KE-37 MnL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfCTWM2OD14LkC3NlU5KM7:TR?= NFHsVlNUSU6JRWK=
RCM-1 NXn0[3g5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzIW21KSzVyPU[uNFc4OTlizszN MX3TRW5ITVJ?
Mewo MmPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mon6TWM2OD14LkGxOFg4KM7:TR?= MVPTRW5ITVJ?
L-428 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fCVWlEPTB;Nj6xPFA{PyEQvF2= MXTTRW5ITVJ?
8-MG-BA M1LZe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrITWM2OD14LkG5N|c6KM7:TR?= M3TmNnNCVkeHUh?=
SK-MEL-28 NVXEZ2hmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXqwSHpNUUN3ME22MlIxQTZ5IN88US=> NHfRdWFUSU6JRWK=
VA-ES-BJ NI\3VY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTZwM{C0OlIh|ryP NGDrcVJUSU6JRWK=
CAL-120 M13aXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzBeG14UUN3ME22MlQ2OTZ{IN88US=> NIXFT2JUSU6JRWK=
GAMG MlHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHZfYVvUUN3ME22MlUxPjJizszN M4DkdnNCVkeHUh?=
MSTO-221H M3zoSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LtV2lEPTB;Nj61NVE4KM7:TR?= Mkm0V2FPT0WU
GCT NUS4cXBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjBV3RlUUN3ME22MlU{Ozh5IN88US=> MUnTRW5ITVJ?
SH-4 MlnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzKTWM2OD14LkW4PFQ1KM7:TR?= NFvsWlZUSU6JRWK=
Calu-3 M1\4cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTZwNkW1Olgh|ryP NFnRZlVUSU6JRWK=
SK-HEP-1 Mo\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXsU45KSzVyPU[uO|E4PTNizszN NGHnUm9USU6JRWK=
PFSK-1 MoXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUD6N3hZUUN3ME22Mlc{PDd6IN88US=> NIPhXIRUSU6JRWK=
NB12 NHvIZYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\qTWM2OD14Lke4OFA1KM7:TR?= NFvkeXZUSU6JRWK=
A388 M2j0UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\OdmJCUUN3ME22Mlg6PTJizszN M3HCeXNCVkeHUh?=
KLE MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDPbFNuUUN3ME22Mlk3PTF4IN88US=> M3LYTHNCVkeHUh?=
TE-11 NEC4ZVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3kTWM2OD15LkC0PVY4KM7:TR?= MWjTRW5ITVJ?
NCI-H2405 NWrHU441T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTdwMEizPVMh|ryP MV\TRW5ITVJ?
OVCAR-4 M4PwVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPGXIdTUUN3ME23MlE2OzVizszN NXTmbZJWW0GQR1XS
KP-N-YS NITUeJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTdwMUixOEDPxE1? NXjiNYhqW0GQR1XS
NOS-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjNZ2VKSzVyPUeuNlU5OjhizszN NFX0ZXNUSU6JRWK=
DMS-114 M2ftXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInnVIJKSzVyPUeuNlk3OzFizszN M2TYUHNCVkeHUh?=
NCI-H2030 NV:yRY9xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4C3[mlEPTB;Nz6zN|Y6QCEQvF2= M1PTcnNCVkeHUh?=
HEL NYj2dVJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{mzdGlEPTB;Nz6zO|UzOSEQvF2= M1zXdXNCVkeHUh?=
CAL-62 NUnKRnhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvQNGc6UUN3ME23MlM6QDZ4IN88US=> MXPTRW5ITVJ?
COLO-668 M2D2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTdwNEO5Olch|ryP MmC0V2FPT0WU
SKG-IIIa MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7QTWM2OD15LkS1N|gyKM7:TR?= NGG0bnNUSU6JRWK=
HCC1419 NEnIXpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\GVmpKSzVyPUeuOFY5OzNizszN MYXTRW5ITVJ?
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ONS-76 NUP6TGc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\STWM2OD1|Nz6xN|A6KM7:TR?= M3n3NHNCVkeHUh?=
T98G M2fRTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnrVoM3UUN3ME2zO{45PjN3IN88US=> M2n5eHNCVkeHUh?=
NB14 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrRPYUyUUN3ME2zPE41PTR2IN88US=> MUTTRW5ITVJ?
D-423MG NH3uNJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TWbGlEPTB;M{iuOFg3QSEQvF2= MYfTRW5ITVJ?
NCI-H510A MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PKWWlEPTB;M{iuOlQ2OSEQvF2= M1nlfnNCVkeHUh?=
NMC-G1 NXS2T2pGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\xeoNKSzVyPUO4MlczOjJizszN MmD6V2FPT0WU
SW948 NULGUol6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHoXHJKSzVyPUO4Mlg6PDlizszN NYLENItIW0GQR1XS
MFM-223 NF;3cGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nVUWlEPTB;M{iuPVQ{OSEQvF2= NX;ZUnlVW0GQR1XS
PAN1 NHWyfWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLGW3RpUUN3ME2zPE46QTF7IN88US=> NGe0bnRUSU6JRWK=
MZ7-mel MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULoSG9qUUN3ME2zPU4yOTl7IN88US=> MlzpV2FPT0WU
COLO-679 NHnSVHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUmwbZRHUUN3ME2zPU46PzB6IN88US=> Ml\jV2FPT0WU
SW872 NHr4fYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2ToXmlEPTB;NECuNlA{OSEQvF2= MVHTRW5ITVJ?
HT-1197 MnHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnOxTWM2OD12MD6yPFY6KM7:TR?= NHvBO2lUSU6JRWK=
ES6 MoP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1z0TWlEPTB;NECuOFU2OiEQvF2= MojRV2FPT0WU
SNU-387 NFLXendIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXZS49KSzVyPUSwMlgzOzhizszN NXHodZU{W0GQR1XS
T47D Mny0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4faNmlEPTB;NEGuNFE6OiEQvF2= MlW3V2FPT0WU
G-402 Mki4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\MRWdMUUN3ME20NU4xQDB7IN88US=> NXfYbYh7W0GQR1XS
MZ1-PC MnPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWftXnd2UUN3ME20NU45OSEQvF2= Mkm2V2FPT0WU
SW1417 MlOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\yTWM2OD12Mj6zNFMh|ryP Mn[5V2FPT0WU
RERF-LC-MS MlLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rw[GlEPTB;NEKuOVA5PyEQvF2= M1:4V3NCVkeHUh?=
SF539 NXXxeFV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTR{LkW1Nlkh|ryP NVSweGdWW0GQR1XS
ESS-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;MW4hKSzVyPUSzMlU2PThizszN M13Cb3NCVkeHUh?=
RO82-W-1 M1;1R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLIUHJKSzVyPUSzMlYyPTNizszN MYrTRW5ITVJ?
S-117 NEXhNYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrMd5BUUUN3ME20N{43QTV6IN88US=> MnyyV2FPT0WU
SW756 NFzGeJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\j[GZsUUN3ME20N{45OjR{IN88US=> Mn:0V2FPT0WU
CP66-MEL Mn;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;TO3lKSzVyPUS1MlcyPDNizszN M3\Z[nNCVkeHUh?=
H-EMC-SS MlXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mke4TWM2OD12NT63Olk{KM7:TR?= MmrXV2FPT0WU
NCI-H2052 Mn;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXrTWM2OD12NT65NFI4KM7:TR?= MofiV2FPT0WU
SW684 MmfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTaTlhrUUN3ME20O{4xODhzIN88US=> MUTTRW5ITVJ?
HCC1569 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\3c41KSzVyPUS3MlE3PThizszN MkH0V2FPT0WU
KGN MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTR5LkOzNVEh|ryP M1fXUXNCVkeHUh?=
LCLC-103H M{TjT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTR5LkS0NFQh|ryP MXfTRW5ITVJ?
SW780 M{fh[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTSOoE{UUN3ME20O{43OzVzIN88US=> M1HOcnNCVkeHUh?=
NCI-H1703 NHO2RnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\VXmFKSzVyPUS4MlM{PTJizszN MYHTRW5ITVJ?
HCC1395 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjJNFJKSzVyPUS4Mlc1OzJizszN MVzTRW5ITVJ?

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

体内試験 Gefitinib (100 mg/kg) improves the anti-tumor effect of radiotherapy in LoVo tumor xenografts. [3] Gefitinib treatment of nude mice bearing established human GEO colon cancer xenografts reveals a reversible dose-dependent inhibition of tumor growth because GEO tumors resumes the growth rate of controls at the end of the treatment. [4]

お薦めの試験操作(参考用のみ)

細胞試験: [1]
+ 展開
  • 細胞株: NR6, NR6M and NR6W cells
  • 濃度: 0-2 μM
  • 反応時間: 72 hours
  • 実験の流れ: Exponentially growing cells including NR6, NR6M, NR6M and NR6W cells are seeded in sextuple in 96-well plates at a concentration of 2000 cells/well, allowed to adhere and subsequently washed in PBS and incubated overnight in medium containing 0.5% FCS. Cells are then treated with varying concentrations (0-2 μM) of Gefitinib or the solute control DMSO and EGF. The optimal EGF concentration for inducing proliferation of NR6wtEGFR and NR6W cells has previously been determined and hence NR6wtEGFR and NR6W cells are supplemented with 10 nM and 0.1 nM EGF, respectively. EGF is not added to NR6 and NR6M cells. After 72 hours the amount of cells are measured by performing a MTT proliferation assay.
    (参考用のみ)
動物試験:[3]
+ 展開
  • 動物モデル: Female nude mice (cba nu/nu) aged 8–10 weeks are intra-dermal injected with LoVo cells.
  • 製剤: 0.5% polysorbate
  • 投薬量: 100 mg/kg
  • 投与方法: Once daily by oral administration (0.1 mL/10 g body weight) for 14 days
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 89 mg/mL (199.14 mM)
Ethanol 4 mg/mL (8.95 mM)
Water Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
1% CMC Na
混合させたのち直ちに使用することを推奨します。
30mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 446.90
化学式

C22H24ClFN4O3

CAS No. 184475-35-2
保管
in solvent
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03866499 Not yet recruiting NSCLC Beta Pharma Inc. May 2019 Phase 3
NCT03866499 Not yet recruiting NSCLC Beta Pharma Inc. May 2019 Phase 3
NCT03787992 Not yet recruiting Locally Advanced or Metastatic EGFR Sensitising Mutation Positive Non-small Cell Lung Cancer Allist Pharmaceuticals Inc. April 1 2019 Phase 3
NCT03787992 Not yet recruiting Locally Advanced or Metastatic EGFR Sensitising Mutation Positive Non-small Cell Lung Cancer Allist Pharmaceuticals Inc. April 1 2019 Phase 3
NCT03766490 Not yet recruiting Non-Small-Cell Lung The First Affiliated Hospital of Soochow University|The First People''s Hospital of Changzhou|Second Affiliated Hospital of Soochow University|Nantong University|Affiliated Hospital of Jiangnan University|Jiangyin People''s Hospital|Changzhou No.2 People''s Hospital|Chia Tai Tianqing Pharmaceutical Group Co. Ltd. March 30 2019 Not Applicable
NCT03856697 Not yet recruiting Advanced Non-small Cell Lung Cancer Hangzhou ACEA Pharmaceutical Research Co. Ltd.|Guangdong Provincial People''s Hospital March 2019 Phase 3

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    I try to dissolve Gefitinib (ZD1839) in 0.5% methylcellulose+0.2% Tween 80 for in vivo experiments. However, when I prepare the mixture, it forms precipitates. Exists another way to dissolve completely the compound?

  • 回答:

    S1025 can be dissovled in both 5% DMSO+corn oil and 5% DMSO+30% PEG 300+5% Tween 80+ddH2O at 2.5 mg/ml clearly. It dissolves in DMSO not readily, please sonicate and warm it in water bath at about 45 degree, and dissolve it clearly first. Then add other solvent.

EGFRシグナル伝達経路

EGFR Inhibitors with Unique Features

相関EGFR製品

Tags: Gefitinib (ZD1839)を買う | Gefitinib (ZD1839) ic50 | Gefitinib (ZD1839)供給者 | Gefitinib (ZD1839)を購入する | Gefitinib (ZD1839)費用 | Gefitinib (ZD1839)生産者 | オーダーGefitinib (ZD1839) | Gefitinib (ZD1839)化学構造 | Gefitinib (ZD1839)分子量 | Gefitinib (ZD1839)代理店
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