Dactolisib (BEZ235)

For research use only. Not for use in humans.

製品コードS1009 別名:NVP-BEZ235

Dactolisib (BEZ235)化学構造

CAS No. 915019-65-7

Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell. Dactolisib induces autophagy and suppresses HIV-1 replication. Phase 2.

サイズ 価格(税別)  
JPY 20200
JPY 46400
最寄りの販売代理店を探す

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バルク問合せ

文献中Selleckの製品使用例(408)

製品安全説明書

PI3K阻害剤の選択性比較

生物活性

製品説明 Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell. Dactolisib induces autophagy and suppresses HIV-1 replication. Phase 2.
ターゲット
p110α [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR (p70S6K) [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
ATR [8]
(3T3TopBP1-ER cells)
4 nM 5 nM 6 nM 7 nM 21 nM
体外試験

BEZ235 significantly reduces the phosphorylation levels of the mTOR activated kinase p70S6K. BEZ235 results in a reduction of S235/S236P-RPS6 levels with IC50 of 6.5 nM. The activity of BEZ235 against mTOR is determined using a biochemical mTOR K-LISA assay with IC50 of 20.7 nM. BEZ235 shows slightly lower activity against its β paralogue with IC50 of 75 nM. The PI3K/Akt/mTOR pathway is often constitutively activated in human tumor cells. BEZ235 blocks PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Both PTEN-null cell lines PC3M and U87MG show a dose-dependent reduction in cell proliferation when treated with increasing concentrations of BEZ235 with an average GI50 of 10-12 nM. [1] BEZ235 is an mTORC1/2 catalytic inhibitor. [2]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Trypanosoma brucei brucei M1HVfWFvfGmvaXPyc4Jq[WxiQYPzZZk> NFHxeHYyQCCq NWS4empnTE2VTx?= MUTBcpRqfHK7cHHuc5NwdWGuIHHjeIl3cXS7IIfpeIghTUN3MDDv[kAxNjByMkWg{txO NGnMeoU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEiwOVk1Pid-MkS4NFU6PDZ:L3G+
MCF7 NVzG[GxVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NES4d5kxNjBzLUGwNEDPxE1? NX;hfnlMPDhiaB?= MYLEUXNQ NIjTZ5hKSzVyPUCuO|Mh|ryP MlfDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6N{G5NFQoRjJ|OEexPVA1RC:jPh?=
HCT116 NXG2dmp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWewMlAyNTFyMDFOwG0> NXH0fG5WPDhiaB?= NGTRS4pFVVOR MULJR|UxRTFwMU[g{txO NXH0VYJLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4O|E6ODRpPkKzPFcyQTB2PD;hQi=>
U87MG M4mzZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYC3R2hZOC5yMT2xNFAh|ryP MlXVOFghcA>? MVvEUXNQ M1HTV2lEPTB;MT6zNkDPxE1? NH;xUYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i3NVkxPCd-MkO4O|E6ODR:L3G+
HBC4 NWnsXmpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEKwVXIxNjBzLUGwNEDPxE1? M4nKfVQ5KGh? M1ryc2xw\yCJSUWwQU05NjZzIF2= MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
BSY1 M2PocGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3PNE4xOS1zMECg{txO M1fqdVQ5KGh? NUfUbW5OVG:pIFfJOVA:NThwNEigUS=> NVPCbYp2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
HBC5 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3TdXQxNjBzLUGwNEDPxE1? M3Pi[VQ5KGh? Ml;WUI9oKEeLNUC9MVcvQDdiTR?= NYHwfIl4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
MCF7 NIHEWVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jFTlAvODFvMUCwJO69VQ>? MWO0PEBp NFW2dnRNd2diR1m1NF0uQC5zNjDN MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
MDA-MB-231 M3jFd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVSwMlAyNTFyMDFOwG0> Ml3HOFghcA>? NYPLXXFzVG:pIFfJOVA:NThwMEmgUS=> NVLpfFQxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
U251 NYnhN|Z[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDLR2F1OC5yMT2xNFAh|ryP NUCzS3hIPDhiaB?= M{m5fWxw\yCJSUWwQU04NjZ4IF2= NGf2UYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
SF268 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmruNE4xOS1zMECg{txO NVPNNWtuPDhiaB?= M1u4SWxw\yCJSUWwQU04Njl{IF2= MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
SF295 NWXBN3BvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{n1NlAvODFvMUCwJO69VQ>? MkPmOFghcA>? M{W4cGxw\yCJSUWwQU05NjNzIF2= NGXMfXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
SF539 NFPxNnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2q2T|AvODFvMUCwJO69VQ>? M4jNclQ5KGh? Ml3iUI9oKEeLNUC9MVgvPTliTR?= MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
SNB75 MmS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLIWGd7OC5yMT2xNFAh|ryP MoWwOFghcA>? MmLhUI9oKEeLNUC9MVgvPThiTR?= M1HDd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
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HCC2998 NFXoN|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTST3VmOC5yMT2xNFAh|ryP M2q5XFQ5KGh? MXTMc4chT0l3ME2tPE4xPSCP NFnsSm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
KM12 NELyflZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfQeXRLOC5yMT2xNFAh|ryP NFjkR5c1QCCq M2LEXGxw\yCJSUWwQU04NjV2IF2= MkOyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
HT-29 M37rWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mof1NE4xOS1zMECg{txO MYG0PEBp NGnXPFFNd2diR1m1NF0uPy55NTDN MkXNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
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HCT116 NHPpb|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV6wMlAyNTFyMDFOwG0> NVvjfYZPPDhiaB?= MnTtUI9oKEeLNUC9MVcvPjFiTR?= NHH4fG49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
NCI-H23 NXvVSmpRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXkSWtiOC5yMT2xNFAh|ryP MYm0PEBp MUXMc4chT0l3ME2tO{43PCCP NUfQfm1oRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
NCI-H226 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LyW|AvODFvMUCwJO69VQ>? NUXpNIs6PDhiaB?= NXPsXlNtVG:pIFfJOVA:NThwNESgUS=> NXrxeHNZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
NCI-H522 MkjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULWSolVOC5yMT2xNFAh|ryP MYi0PEBp MWDMc4chT0l3ME2tPE41PSCP NUnOfol2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
NCI-H438 NYLUVI9YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVWwMlAyNTFyMDFOwG0> Mn;6OFghcA>? NX60[YZ3VG:pIFfJOVA:NThwMUGgUS=> M2m2WVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
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DMS273 NVvGUoVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX:wMlAyNTFyMDFOwG0> MUS0PEBp MUDMc4chT0l3ME2tO{45OCCP NX35[Ww6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
DMS114 NWr2bJJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjINE4xOS1zMECg{txO MYK0PEBp M4fh[Gxw\yCJSUWwQU05NjN7IF2= M1XnOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
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OVCAR3 MlfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUOwMlAyNTFyMDFOwG0> MoG3OFghcA>? NW\zeHNjVG:pIFfJOVA:NThwMUegUS=> NGq0ZYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
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OVCAR5 M{f6cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzpNE4xOS1zMECg{txO M1jI[lQ5KGh? M1XLN2xw\yCJSUWwQU04NjV5IF2= M1PZdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
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SKOV3 NGLtcJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXKV4IxNjBzLUGwNEDPxE1? M1\3clQ5KGh? M3X6Nmxw\yCJSUWwQU05NjRzIF2= M3jySFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
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ACHN NU\QUmF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NES0PZcxNjBzLUGwNEDPxE1? MV[0PEBp M{\v[2xw\yCJSUWwQU04Njl3IF2= MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
St-4 NGLrOlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYKwMlAyNTFyMDFOwG0> M3XwdVQ5KGh? NEiyTlZNd2diR1m1NF0uPy52NzDN MmXMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
MKN1 NGrRRm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUSwMlAyNTFyMDFOwG0> NYDH[GpKPDhiaB?= MXHMc4chT0l3ME2tPE41OSCP NVOyc5M1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
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MKN28 NGLEbHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHONE4xOS1zMECg{txO NEXRcoc1QCCq M{ixbGxw\yCJSUWwQU04NjB5IF2= NF;X[JY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
MKN45 M1P3cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXiVZExNjBzLUGwNEDPxE1? NXnVXVRDPDhiaB?= NHH1eGxNd2diR1m1NF0uQC5|NDDN M4rJRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
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LU-139 NIL6TYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWH1SVVMUUN3ME23Mlc4KG6P NIK1Row9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
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A549 NGfJV3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{THfWlEPTB;MUCuNVQhdk1? NVvRV3pJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
769-P M4PKPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmWzTWM2OD1zMD60OEBvVQ>? NFvhS289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
L-363 M1SzbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrnVJNKSzVyPUGwMlY6KG6P M{\meVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
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PA-1 NFPBXY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLEe|k6UUN3ME2xNU45OiCwTR?= NF\TbXE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
Mewo NGrDdGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7jTWM2OD1zMT65PUBvVQ>? NIDTfIk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
HSC-3 NEnFSWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\hTWM2OD1zMj6yNUBvVQ>? MmDJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
H4 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;IZZN5UUN3ME2xNk43PyCwTR?= NFvYVXA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
BB65-RCC M{HydGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTF{LkeyJI5O MojZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
NCI-H1793 NH;DdWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorlTWM2OD1zMj64NkBvVQ>? NWH2cFdzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
KARPAS-45 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTF|LkWxJI5O NVfhbXVGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
GCT MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUGzNVRxUUN3ME2xN{43QCCwTR?= MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
EoL-1 MnvaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvMTWM2OD1zMz65N{BvVQ>? Mn7DQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
LB2241-RCC M1voTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3GOIU3UUN3ME2xOE4xOSCwTR?= NF;HWGU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
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COR-L105 NVjlVXY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTD[oc3UUN3ME2xOU4xPCCwTR?= NF7LelQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
P12-ICHIKAWA NITSTXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPESYRbUUN3ME2xOU4yKG6P NEnPfFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
CHL-1 Mn\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYSzRXB6UUN3ME2xOU41PSCwTR?= M1;HXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
VMRC-RCZ MkTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHOWItKSzVyPUG1MlY{KG6P MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
HH MmjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnuTG1QUUN3ME2xOU44KG6P MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
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