Tanespimycin (17-AAG)

製品コードS1141 別名:CP127374,NSC-330507, KOS 953

Tanespimycin (17-AAG)化学構造

分子量(MW):585.69

Tanespimycin (17-AAG) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.

サイズ 価格(税別)  
JPY 32370.00
JPY 24900.00
JPY 61420.00

カスタマーフィードバック(9)

  • (A) Cell lines were seeded in 96-well plates and treated with 10 nM of 17-AAG for 72 h. Cell survival was analyzed using CellTiter-Glo. Both parental H3122 cells (red bar) and H3122 CR cells (blue bar) show sensitivity to 17-AAG. (B) Suppression of ALK signaling by 17-AAG in resistant H3122 CR cells. H3122 parental and resistant cells were exposed to increasing concentrations of 17-AAG for 6 h.

    PNAS, 2011, 108: 7535-40. Tanespimycin (17-AAG) purchased from Selleck.

    (A) Treatment of DIPG cells with an HSP90 inhibitor, 17-AAG, resulted in decreased invasion toward SVZ hNPC CM at high doses. (B) Cell viability of DIPG cells treated with increasing doses of 17-AAG, by the CellTiter-Glo assay.

    Cell, 2017, 170(5):845-859.e19. Tanespimycin (17-AAG) purchased from Selleck.

  • SKBR3 cells were treated with FW-04-806 at 10, 20, 40 uM for 24 h; 17AAG was used as a positive control at 1 and 2 uM. Hsp70, Hsp90, and Cdc37 protein level were analyzed with western blotting using relevant antibodies.

    Mol Cancer 2014 13, 150. Tanespimycin (17-AAG) purchased from Selleck.

    Western blot analysis of immunoprecipitated Hsp90/BIP complexes in MOLT-4 (T-ALL) and RS4;11 (B-ALL) treated for 22 h with CX-4945 (5 μM) and bortezomib (2.5 nM) either alone or in combination. 500 μg of protein lysates were immunoprecipitated with anti-Hsp90 antibody. Relative Induction values (Rel.Ind.) were obtained by normalizing to Hsp90 bands density. 17-AAG: tanespimycin.

    Oncotarget, 2015, 51: S659-S660. Tanespimycin (17-AAG) purchased from Selleck.

  • Co-IP analyses of direct interaction between HSP90 and HIF-1α in 17-AAG (5 μM)-treated HSCs using antibodies against HSP90, HIF-1α or IgG (n = 2).

    Br J Pharmacol, 2017, 174(5):409-423. Tanespimycin (17-AAG) purchased from Selleck.

    Treatment with an Hsp90 inhibitor results in a dose-dependent decrease in complex IV activity. A, because Hsp90 levels were reduced by 80%, in PINK1 null dopaminergic neuronal cells, the effects of specific inhibition of Hsp90 using 17-AAG were analyzed in wild-type neuronal cells. Both complex IV activity and Hsp60 levels were decreased significantly in 17-AAG-treated cells in a dose-dependent manner. B, in contrast, 17-AAG treatment did not affect expression of Hsp90 and LRPPRC.

    J Biol Chem 2012 287, 44109-20. Tanespimycin (17-AAG) purchased from Selleck.

  • UPR modulators destabilize mSmoM2. NIH 3T3 cells expressing mSmoM2 protein were treated with HSP90 inhibitors 17-AAG (50 uM and 100 uM) and SNX-2112 (25 uM and 50 uM) and the proteasome inhibitor bortezomib (25 uM and 50 uM) for 4 h prior to lysis. DMSO was the vehicle control. Western blotting of whole-cell lysates revealed mSmoM2 protein to be destabilized in response to HSP-90 inhibitors but not in response to bortezomib. Tubulin was the loading control. CHOP results indicate ER stress.

    Mol Cell Biol 2013 33(12), 2375-87. Tanespimycin (17-AAG) purchased from Selleck.

    Hsp90 is up-regulated during aging. Whole-cell extracts were prepared from young (PD 20) and old (PD 40) HFSN1 cells. c HFSN1 cells (PD 40) were treated with different concentration of the Hsp90 inhibitor (17-AAG) and then re-incubated for 24 h. Whole-cell extracts were prepared and analyzed by western blot using the indicated antibodies.

    Age 2013 35, 549-62. Tanespimycin (17-AAG) purchased from Selleck.

  • Four types of the colon cancer cells with indicated K-Ras phenotype were incubated with indicated concentration of 17-AAG for 24 h, which were then analyzed for protein expression by WB.

    Oncotarget 2014 5, 4269-82. Tanespimycin (17-AAG) purchased from Selleck.

製品安全説明書

HSP (e.g. HSP90)阻害剤の選択性比較

生物活性

製品説明 Tanespimycin (17-AAG) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.
特性 Displays very low toxicity toward normal cells.
ターゲット
HSP90 [1]
(Cell-free assay)
5 nM
体外試験

17-AAG, an analog of geldanamycin, exhibits greater than 100 times higher binding affinity for Hsp90 derived from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells with IC50 values of 5-6 nM. [1] 17-AAG causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells such as LNCaP, LAPC-4, DU-145, and PC-3 with IC50 values of 25-45 nM. [2] In addition to inducing apoptosis of Ba/F3 cells transformed with wild-type BCR-ABL with an IC50 of 5.2 μM, 17-AAG has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively, by inducing the degradation of both wild-type BCR-ABL protein and mutants. [3]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A549 M1LHZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\sd4Z3UUN3ME2wMlAxODNyMzFOwG0> NULUToJjW0GQR1XS
IST-MEL1 NYnVOGt[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYH0[o1pUUN3ME2wMlAxODRyNzFOwG0> MlfNV2FPT0WU
NCI-SNU-1 NHW4fodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvnWlFKSzVyPUCuNFAzODdizszN MUPTRW5ITVJ?
FADU MnXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PxdmlEPTB;MD6wNFIxQSEQvF2= MnvMV2FPT0WU
C32 NYfFeVNyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfCfnpCUUN3ME2wMlAxOzB2IN88US=> NEHNZWJUSU6JRWK=
D-566MG NV7Z[YZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrOT21KSzVyPUCuNFA{QSEQvF2= MULTRW5ITVJ?
LXF-289 NXnGUnlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DTTmlEPTB;MD6wNFQyQSEQvF2= NES1eYlUSU6JRWK=
HGC-27 NF3DZ2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rBVWlEPTB;MD6wNFUyKM7:TR?= MWjTRW5ITVJ?
RPMI-7951 NUDjeVVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXjNldKSzVyPUCuNFA4OTdizszN NVX1dGp3W0GQR1XS
HSC-3 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPsNoNmUUN3ME2wMlAxQTJ7IN88US=> Mlz6V2FPT0WU
MIA-PaCa-2 NIftOodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFGxUolKSzVyPUCuNFExODlizszN MWXTRW5ITVJ?
KS-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XqeWlEPTB;MD6wNVM2PSEQvF2= NIrsfVNUSU6JRWK=
CAL-51 NXHLeWxCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fIfGlEPTB;MD6wNVQxPSEQvF2= M4LwW3NCVkeHUh?=
MDA-MB-361 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHFNGZKSzVyPUCuNFE1QTVizszN NWjBTpBwW0GQR1XS
TI-73 NVL6b25RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPMTWM2OD1yLkCxO|k3KM7:TR?= M{TjS3NCVkeHUh?=
AGS M3q4XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHmTWM2OD1yLkCxPVM5KM7:TR?= NVLITlJ[W0GQR1XS
NCI-H460 M2e0c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rWV2lEPTB;MD6wNVk4PCEQvF2= MkG3V2FPT0WU
A204 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwMEKyOFkh|ryP M1r0cnNCVkeHUh?=
CHL-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTjNWNZUUN3ME2wMlAzOjVzIN88US=> MljVV2FPT0WU
DU-4475 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17UPWlEPTB;MD6wNlI3OSEQvF2= Ml\zV2FPT0WU
CGTH-W-1 NVH3NWtxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PG[mlEPTB;MD6wNlM1QSEQvF2= MU\TRW5ITVJ?
HCC2218 M4fOcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XJSmlEPTB;MD6wNlQ6PCEQvF2= NXzw[IhmW0GQR1XS
A2780 MkDTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE[4b|FKSzVyPUCuNFI2OzFizszN M37Md3NCVkeHUh?=
NCI-H720 NEHOc4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TmfWlEPTB;MD6wNlU1PiEQvF2= NVrw[nlvW0GQR1XS
NCI-N87 NYL5ZYhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwMEK1PVMh|ryP NX\GdIMyW0GQR1XS
CHP-212 NYO4eo12T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjafFl1UUN3ME2wMlAzPjJ6IN88US=> NGrveIRUSU6JRWK=
NCI-H23 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmG3TWM2OD1yLkCyOlY2KM7:TR?= NXnDWWd5W0GQR1XS
D-263MG NYHDV|ZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwMEK3PFYh|ryP M1\Hd3NCVkeHUh?=
ME-180 M3fCeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwMEK4PVEh|ryP Mni3V2FPT0WU
SW982 MmrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwMEK5PVkh|ryP M4H0WnNCVkeHUh?=
OE19 M4[0SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMEOwO|ch|ryP MWrTRW5ITVJ?
SK-LU-1 NH;kN2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1i2Z2lEPTB;MD6wN|A5OiEQvF2= MUTTRW5ITVJ?
H4 NFnyNmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjLTWM2OD1yLkCzNFkh|ryP MXfTRW5ITVJ?
HT-144 NEixb4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTYWJlQUUN3ME2wMlA{ODl|IN88US=> MYXTRW5ITVJ?
SK-UT-1 NI[xNYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwMEOxO|gh|ryP MUHTRW5ITVJ?
D-336MG M2nmS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\nXGlEPTB;MD6wN|MxQSEQvF2= NF3Tb4tUSU6JRWK=
MDA-MB-175-VII NGL3XXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEX0ZmlKSzVyPUCuNFM{PTRizszN MVPTRW5ITVJ?
GAMG MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwMEO0N|Uh|ryP NIniT|RUSU6JRWK=
CP50-MEL-B NXS4[4V3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fCeWlEPTB;MD6wN|Q2KM7:TR?= NEDSTlNUSU6JRWK=
OVCAR-5 M13NVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDPc|FKSzVyPUCuNFM1QCEQvF2= M3S4RXNCVkeHUh?=
SK-MES-1 NYqzNpV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\LVJhFUUN3ME2wMlA{PjB4IN88US=> MVvTRW5ITVJ?
VM-CUB-1 MofaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nnS2lEPTB;MD6wN|Y2PyEQvF2= MV7TRW5ITVJ?
WM-115 NUPhUXhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvZTWM2OD1yLkCzO|YzKM7:TR?= NXPMUIEzW0GQR1XS
DSH1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLBTWM2OD1yLkCzPFA4KM7:TR?= NWPnS|RYW0GQR1XS
Becker M1LVRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMEO4PFUh|ryP NVnKWo5{W0GQR1XS
SW962 NEHDN2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\QZY8{UUN3ME2wMlA{QTR3IN88US=> NF\SPXZUSU6JRWK=
TYK-nu NGXhdJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzqW4RKSzVyPUCuNFM6QDVizszN NWXF[4tCW0GQR1XS
HO-1-N-1 NVS2bXo6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPJN4ZKSzVyPUCuNFQxOjFizszN MYnTRW5ITVJ?
T98G NXf0dodCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1Twb2lEPTB;MD6wOFExOyEQvF2= MofOV2FPT0WU
ACN MoXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMESxOlIh|ryP MVLTRW5ITVJ?
SW780 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3zW3pKSzVyPUCuNFQzODNizszN NXrmOFFTW0GQR1XS
Detroit562 NX;nS4E1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYT2VXoyUUN3ME2wMlA1OjN7IN88US=> NYXUboNEW0GQR1XS
BB49-HNC NX7a[2Y{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnO[4NFUUN3ME2wMlA1OjR|IN88US=> M1LwN3NCVkeHUh?=
HN Ml\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\JTWM2OD1yLkC0NlczKM7:TR?= MlHuV2FPT0WU
H9 M2PTOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvVeVJKSzVyPUCuNFQ{PzFizszN MXrTRW5ITVJ?
VA-ES-BJ MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXwTWM2OD1yLkC0OFQ4KM7:TR?= NEXZZWNUSU6JRWK=
MEL-JUSO NX\RVJk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXz5bmNUUUN3ME2wMlA1PDd3IN88US=> MVjTRW5ITVJ?
BT-474 NWDubpVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkmwTWM2OD1yLkC0OUDPxE1? MX;TRW5ITVJ?
CaR-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMES1OFkh|ryP NUTRfYdoW0GQR1XS
PSN1 MkPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;ZSWlEPTB;MD6wOFYxOyEQvF2= M3vDPXNCVkeHUh?=
KYSE-510 NEXCZlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPzOJA1UUN3ME2wMlA1PjR7IN88US=> NUXGNWVMW0GQR1XS
KP-4 MoHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMES3OVMh|ryP NHj4SlZUSU6JRWK=
KYSE-410 MnvwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV64eJBCUUN3ME2wMlA1Pzd{IN88US=> NVzMZmZHW0GQR1XS
G-402 NHTMTZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwMES3PFkh|ryP M1\j[HNCVkeHUh?=
DOK MoDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInIUoZKSzVyPUCuNFQ6ODJizszN M2\pZXNCVkeHUh?=
COR-L88 NWLZXIM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fVR2lEPTB;MD6wOFkyOiEQvF2= NU\MNJJTW0GQR1XS
SKG-IIIa MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPHTWM2OD1yLkC0PVg3KM7:TR?= NXG4NnQxW0GQR1XS
AN3-CA M3u4emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXHSYJ6UUN3ME2wMlA2KM7:TR?= NUjsZpNIW0GQR1XS
SW48 NH6xWXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHpcnVKSzVyPUCuNFUxOzlizszN M2fPZnNCVkeHUh?=
YKG-1 M3;Ib2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLpOm1SUUN3ME2wMlA2ODdzIN88US=> MnjVV2FPT0WU
KYSE-150 M{GyUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXuNHB4UUN3ME2wMlA2OjN3IN88US=> MXHTRW5ITVJ?
HuO-3N1 NH:1d5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\iTWM2OD1yLkC1NlM4KM7:TR?= NFPXR5RUSU6JRWK=
LB1047-RCC NVfmWGN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMEWyPVYh|ryP MVPTRW5ITVJ?
NCI-H2030 NIPq[GhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmG3TWM2OD1yLkC1OFE1KM7:TR?= MXXTRW5ITVJ?
YH-13 NYjmbHFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwMEW3NlIh|ryP NYewfpBWW0GQR1XS
5637 MlWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH:3S5ZKSzVyPUCuNFU4PCEQvF2= M4PKcHNCVkeHUh?=
LOXIMVI NWPhNYpCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;uWFh[UUN3ME2wMlA2QDd{IN88US=> MXLTRW5ITVJ?
GT3TKB MoHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\RboI4UUN3ME2wMlA2QTR{IN88US=> NECyT5FUSU6JRWK=
TCCSUP M{XKVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\mTWM2OD1yLkC1PVY1KM7:TR?= NXf1O5pFW0GQR1XS
EPLC-272H M1TMUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3e5WGlEPTB;MD6wOlIxPSEQvF2= Mlf5V2FPT0WU
LU-99A NV3YSnd6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHmXlZJUUN3ME2wMlA3OjN5IN88US=> MoTRV2FPT0WU
NCI-H1755 NEn0c2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHtOFhKSzVyPUCuNFY{PDFizszN NYLRN|EyW0GQR1XS
KM12 NWfJVo1HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwME[zOFgh|ryP MonEV2FPT0WU
SF295 NH3mTFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTWTWM2OD1yLkC2OFUzKM7:TR?= NFfkelRUSU6JRWK=
MZ2-MEL NH\hdHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwME[1OVMh|ryP Ml\rV2FPT0WU
HEC-1 NH\0O2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwME[1PFgh|ryP M1u0dnNCVkeHUh?=
SW684 NF\GfmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwME[1PVEh|ryP M1vPbXNCVkeHUh?=
SF539 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\Xco5KSzVyPUCuNFY3QDFizszN M3PubXNCVkeHUh?=
GMS-10 NV65bINlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlj2TWM2OD1yLkC2Olk6KM7:TR?= NEXvcJpUSU6JRWK=
MV-4-11 M2m5OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXrOotKSzVyPUCuNFY5ODNizszN NH\Tc5lUSU6JRWK=
HT-29 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwME[5NVkh|ryP M1XOOHNCVkeHUh?=
23132-87 M3\GOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwME[5OUDPxE1? M2L3XHNCVkeHUh?=
SW620 NEHvcVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\3U3FKSzVyPUCuNFcxOjZizszN MnfhV2FPT0WU
HCC1806 MmniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYS0PVhjUUN3ME2wMlA4OTNzIN88US=> MUXTRW5ITVJ?
Hs-578-T NF;iPJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfifmZrUUN3ME2wMlA4OjB6IN88US=> MYPTRW5ITVJ?
A2058 Ml[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvLV2JKSzVyPUCuNFczOjhizszN NF;vem9USU6JRWK=
MEL-HO NFPM[WZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMEeyOVUh|ryP NFvvT|ZUSU6JRWK=
HCC2998 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwMEezOFch|ryP NELZbmpUSU6JRWK=
HuO9 NUPnTnh{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwMEe1PFkh|ryP M2HDcHNCVkeHUh?=
CAL-39 NV32blhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDoT|BKSzVyPUCuNFc4PjZizszN M2HMeXNCVkeHUh?=
M14 Ml3nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzaTWM2OD1yLkC3PVE{KM7:TR?= NWX5OIFVW0GQR1XS
BFTC-909 NGHaOoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMEe5Olkh|ryP MlfnV2FPT0WU
TE-11 M2X6[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XMR2lEPTB;MD6wO|k6PiEQvF2= MY\TRW5ITVJ?
TGBC1TKB MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3KT405UUN3ME2wMlA5ODR|IN88US=> NHLzPYhUSU6JRWK=
L-363 NGe3c5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUO2TGU4UUN3ME2wMlA5OjB4IN88US=> MVPTRW5ITVJ?
A431 Mn34S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjzWoZKSzVyPUCuNFgzOSEQvF2= NUi5bm94W0GQR1XS
MKN45 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHFTWM2OD1yLkC4NlE6KM7:TR?= NH\Gb25USU6JRWK=
HT-1080 MkjDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU[4XJhqUUN3ME2wMlA5PDN7IN88US=> MYrTRW5ITVJ?
OVCAR-8 MlTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnucpVKSzVyPUCuNFg3OjJizszN NX7qUIp6W0GQR1XS
LCLC-97TM1 M17nOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NImwZ2ZKSzVyPUCuNFg4OjhizszN MXLTRW5ITVJ?
M059J MoizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTBwMEmwNlch|ryP NVfmV5pSW0GQR1XS
SK-MEL-2 NXfzZYtYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwMEmwOkDPxE1? MmjZV2FPT0WU
TE-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTBwMEmyNFQh|ryP MmjhV2FPT0WU
KYSE-180 M4myO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMEmyOlIh|ryP MW\TRW5ITVJ?
D-247MG NXHUVWN6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMEm0OVUh|ryP M4LrTHNCVkeHUh?=
8-MG-BA NFHr[oJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TPdmlEPTB;MD6wPVQ4OiEQvF2= NH7OVG9USU6JRWK=
NCI-H1792 NULaS3hVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\1SGlEPTB;MD6wPVYyQCEQvF2= MULTRW5ITVJ?
MCF7 M1zNRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTYNoxKSzVyPUCuNFk3PzdizszN NH:zWlZUSU6JRWK=
NCI-H2122 NVrq[FdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXWTWM2OD1yLkC5O|Q2KM7:TR?= MXXTRW5ITVJ?
EFO-27 NHuzUXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTkTWM2OD1yLkC5PVk4KM7:TR?= NUnvbXNRW0GQR1XS
LB2241-RCC MnLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwMUCwOVQh|ryP NYPremtpW0GQR1XS
SN12C NYHzWohNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\rTYFKSzVyPUCuNVAyODdizszN MonjV2FPT0WU
A498 NHjWXnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoS0TWM2OD1yLkGwNVgh|ryP MlHkV2FPT0WU
PANC-03-27 NHHNbHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vGNWlEPTB;MD6xNFI5PiEQvF2= MojTV2FPT0WU
NCI-H1581 Mn7wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHm2T|FKSzVyPUCuNVAzQSEQvF2= NEnqOJZUSU6JRWK=
U-87-MG MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXvTWM2OD1yLkGwN|A4KM7:TR?= MXPTRW5ITVJ?
G-401 NHPZSZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPoTWM2OD1yLkGwN|U{KM7:TR?= MWTTRW5ITVJ?
SiHa MkD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\ZTWM2OD1yLkGwOFg3KM7:TR?= NHrYR|hUSU6JRWK=
U251 NX;lfGNtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3foVWlEPTB;MD6xNFUzPSEQvF2= NHGyZnNUSU6JRWK=
MMAC-SF MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXoT4NKSzVyPUCuNVA2OzFizszN MmWyV2FPT0WU
BB65-RCC M{XyNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XtXmlEPTB;MD6xNFU2PCEQvF2= MYPTRW5ITVJ?
NKM-1 MlXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGC5dJFKSzVyPUCuNVA3PjZizszN M1LrRnNCVkeHUh?=
HD-MY-Z MlruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzaVYxKSzVyPUCuNVA5PzNizszN NGHLZpNUSU6JRWK=
TGBC11TKB NX[yUXVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwMUC5NFMh|ryP MlTMV2FPT0WU
COLO-679 MnHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwMUGyNVEh|ryP NFnyeI9USU6JRWK=
TE-8 NFrQWpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;CWmlEPTB;MD6xNVI3PCEQvF2= NXjVOo5HW0GQR1XS
SK-MEL-28 M{fmc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;Je|E3UUN3ME2wMlEyOzJzIN88US=> NUnVRVNzW0GQR1XS
SH-4 MmTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLCWo9WUUN3ME2wMlEyOzV4IN88US=> NGfJVpBUSU6JRWK=
KALS-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMUGzPVMh|ryP M2n3enNCVkeHUh?=
RKO Mlu5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fheWlEPTB;MD6xNVc3PCEQvF2= MXzTRW5ITVJ?
OMC-1 MoXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrwNXRKSzVyPUCuNVE4QTdizszN NYfBXnNLW0GQR1XS
BT-549 NFL5e|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfpTWM2OD1yLkGxO|k6KM7:TR?= NUXEU|lKW0GQR1XS
NCI-H28 NGq3UoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH20dIxKSzVyPUCuNVE5OTdizszN NG\VWFFUSU6JRWK=
RXF393 M3TVfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTBwMUG5PFIh|ryP MYjTRW5ITVJ?
COLO-829 NGXMcoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1uxeGlEPTB;MD6xNlAxPSEQvF2= NX;tNWNJW0GQR1XS
HMV-II MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfVU4hKSzVyPUCuNVIxOiEQvF2= NHTWVI1USU6JRWK=
SW1990 NFfx[FhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwMUKxOVch|ryP NVvGOHREW0GQR1XS
NCI-H1437 NVS2To1xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWC3[YhoUUN3ME2wMlEzOTV5IN88US=> NHXMPJJUSU6JRWK=
SNB75 MlHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DtPGlEPTB;MD6xNlE3QSEQvF2= NFrNc|hUSU6JRWK=
EW-3 NUG5WYVFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4r2[mlEPTB;MD6xNlY3OSEQvF2= NE[y[FBUSU6JRWK=
SAS MmW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYD3O4g2UUN3ME2wMlEzPjlizszN M173R3NCVkeHUh?=
NCI-H1666 M{fPOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml:3TWM2OD1yLkGyO|c1KM7:TR?= MVHTRW5ITVJ?
A375 Mn7XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwMUK3O|gh|ryP NWS2[YdPW0GQR1XS
CAMA-1 MnLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkm2TWM2OD1yLkGyPVI1KM7:TR?= MXHTRW5ITVJ?
HuP-T4 NV35blBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwMUK5OFMh|ryP M3XSNnNCVkeHUh?=
NCI-H292 NGnZZ5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwMUOxNUDPxE1? MWnTRW5ITVJ?
PC-14 NHj1e3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHMRZJDUUN3ME2wMlE{OjFzIN88US=> M3TDTHNCVkeHUh?=
BPH-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwMUO0NUDPxE1? NHu2VWdUSU6JRWK=
GAK NWXIPFBIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojsTWM2OD1yLkGzOVY4KM7:TR?= NFvIXlNUSU6JRWK=
VMRC-RCZ MlfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTmUohKSzVyPUCuNVM4PjJizszN NUnHN3gyW0GQR1XS
SK-MEL-24 M3rhTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HLb2lEPTB;MD6xN|g4KM7:TR?= MW\TRW5ITVJ?
LB831-BLC M3HENmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwMUO4PFMh|ryP NVrRZ211W0GQR1XS
NCI-H2452 MlvIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mny1TWM2OD1yLkGzPVU3KM7:TR?= MV7TRW5ITVJ?
RT-112 MnfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjSXmpPUUN3ME2wMlE1ODN3IN88US=> M3OwT3NCVkeHUh?=
GP5d NVvvbVd[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMUSxNFQh|ryP NXP3eIxzW0GQR1XS
LC-2-ad MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfHTWM2OD1yLkG0NVIyKM7:TR?= NFnUU3RUSU6JRWK=
MPP-89 NIHXWXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TaNGlEPTB;MD6xOFEzPSEQvF2= NGX4RZdUSU6JRWK=
NUGC-3 NHHycnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHEeW1KSzVyPUCuNVQ1PzhizszN M4L6WXNCVkeHUh?=
GI-1 M1zKe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITDXHFKSzVyPUCuNVQ2PThizszN NIjOVHhUSU6JRWK=
HCC1419 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13ONmlEPTB;MD6xOFU4PiEQvF2= M4\o[HNCVkeHUh?=
SW1573 M3TTU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnywTWM2OD1yLkG0O|U5KM7:TR?= NFrtPG9USU6JRWK=
NCI-H2347 M4D2Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{e5W2lEPTB;MD6xOFg{QSEQvF2= NX2wdGtuW0GQR1XS
Mewo Ml\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLTTWM2OD1yLkG0PFg6KM7:TR?= NFPpZ2hUSU6JRWK=
639-V MlvoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwMUWwNVMh|ryP MlLxV2FPT0WU
AsPC-1 NIXjcXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrMboFsUUN3ME2wMlE2OjJ3IN88US=> M3LvfXNCVkeHUh?=
NCI-H1648 M4rrO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\XWYduUUN3ME2wMlE2OjN{IN88US=> NFzXfnBUSU6JRWK=
786-0 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIH2fY1KSzVyPUCuNVU{QDFizszN M1L2bHNCVkeHUh?=
ETK-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwMUW5JO69VQ>? M4LVcXNCVkeHUh?=
BxPC-3 M{HHO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwMUW5OlYh|ryP NF7rSGNUSU6JRWK=
CAL-62 NYLNV45oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NISxTItKSzVyPUCuNVYyPjlizszN NWi2emE2W0GQR1XS
HCC1937 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3GZYhKSzVyPUCuNVYzPzVizszN NXv6VolQW0GQR1XS
NCI-H1299 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PMRmlEPTB;MD6xOlI5PSEQvF2= NH3TTWpUSU6JRWK=
SW1088 M4nSZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXxSnRKSzVyPUCuNVY1OTNizszN MkLNV2FPT0WU
FTC-133 NUTYfWx5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXS0b4doUUN3ME2wMlE3PTRizszN NY\DTW1PW0GQR1XS
OC-314 M1PD[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TpSWlEPTB;MD6xOlY6KM7:TR?= MVrTRW5ITVJ?
SCC-9 M4T2dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\UdGlEPTB;MD6xOlcyPiEQvF2= MnrZV2FPT0WU
HT-1376 NHzTcZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDMTWM2OD1yLkG2PVM3KM7:TR?= MUDTRW5ITVJ?
U-2-OS M1nsRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWf5SIs3UUN3ME2wMlE4OTd|IN88US=> MYnTRW5ITVJ?
COLO-824 MnX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrrc5ByUUN3ME2wMlE4Ojl2IN88US=> MnzvV2FPT0WU
BB30-HNC M{DndGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwMUezN{DPxE1? MX3TRW5ITVJ?
NCI-H2087 MnjNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnq4TWM2OD1yLkG3N|Y5KM7:TR?= NVnjUVFTW0GQR1XS
NCI-H2170 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HYOWlEPTB;MD6xO|U{PiEQvF2= Ml;kV2FPT0WU
SK-OV-3 NG\TWlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMUe1O|Eh|ryP M1i2SnNCVkeHUh?=
MZ7-mel NUHHSoU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXHVIxQUUN3ME2wMlE4PjR7IN88US=> NETEXpFUSU6JRWK=
NCI-H650 NWPocVhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwMUe2PFIh|ryP NX3NUGtKW0GQR1XS
KOSC-2 Mn;oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwMUe3N|Qh|ryP NIW3O5JUSU6JRWK=
SCC-4 NFfBVFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3IVG9xUUN3ME2wMlE4Pzd5IN88US=> M3\RNnNCVkeHUh?=
MDA-MB-157 MkXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzPcVlHUUN3ME2wMlE5ODh{IN88US=> M37jcXNCVkeHUh?=
KYSE-520 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnGTWM2OD1yLkG4NkDPxE1? M1XncnNCVkeHUh?=
LK-2 NXjqNVlxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LncWlEPTB;MD6xPFMxOyEQvF2= NWXxWlBsW0GQR1XS
KNS-81-FD M1fCOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwMUizPVQh|ryP NES3RZNUSU6JRWK=
IGROV-1 NVq0SmpYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DofGlEPTB;MD6xPFQ1OyEQvF2= NV;MPVJRW0GQR1XS
DEL NXTqbVN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULZfYdMUUN3ME2wMlE5PDVizszN MlHDV2FPT0WU
NCI-H1395 MoW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMUi2PFIh|ryP NF[x[oxUSU6JRWK=
JEG-3 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMUi3NFUh|ryP MVTTRW5ITVJ?
BCPAP MlnCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwMUi4O|Ih|ryP MlXaV2FPT0WU
CAL-27 NHPkVllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Po[WlEPTB;MD6xPVAzOiEQvF2= MkHXV2FPT0WU
RD NXnYfpJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjZTWM2OD1yLkG5NVE{KM7:TR?= M1rpOnNCVkeHUh?=
RVH-421 MmjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LtSmlEPTB;MD6xPVEyPiEQvF2= MnXkV2FPT0WU
Capan-2 NYnqdHNkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PS[GlEPTB;MD6xPVI2PiEQvF2= NEXESlJUSU6JRWK=
COLO-680N MnfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXPTWM2OD1yLkG5N|Y1KM7:TR?= M2D0fHNCVkeHUh?=
NCI-H1650 Ml3CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTBwMkCwOVch|ryP MV\TRW5ITVJ?
SBC-5 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLpTWM2OD1yLkKwNVE5KM7:TR?= MnLBV2FPT0WU
U031 NUjJbXk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMkC1OFch|ryP NGC4dWJUSU6JRWK=
S-117 M{[0WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NET1R2RKSzVyPUCuNlA2PjRizszN NWTZdJRRW0GQR1XS
DoTc2-4510 MoPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHqOZRKSzVyPUCuNlA4PjlizszN M{TPSHNCVkeHUh?=
AM-38 NIXSTGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rTPGlEPTB;MD6yNFg1QCEQvF2= NGjDZ4VUSU6JRWK=
A172 NH7yOVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX[zfoFoUUN3ME2wMlIyODJ{IN88US=> NUn4SoJuW0GQR1XS
HPAF-II NEDS[|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITDN45KSzVyPUCuNlEzPjRizszN NI\ETnpUSU6JRWK=
769-P MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1j4W2lEPTB;MD6yNVI5KM7:TR?= NX2wZll3W0GQR1XS
MFE-280 M2PwZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4C5PWlEPTB;MD6yNVI6QCEQvF2= MYHTRW5ITVJ?
TE-9 M{HTTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHf1ToNKSzVyPUCuNlE4QDZizszN MWrTRW5ITVJ?
C2BBe1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DobGlEPTB;MD6yNlE6KM7:TR?= NGjHVGJUSU6JRWK=
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NCI-H661 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnFNVlYUUN3ME2wMlYyOTB2IN88US=> MULTRW5ITVJ?
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BV-173 MkX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV[0bYlmUUN3ME2wMlY5Pjd7IN88US=> M{LXRXNCVkeHUh?=
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ES1 NU\pdYRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTRwOE[wOVch|ryP MoO2V2FPT0WU
SF126 MoHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTRwOUOxPFQh|ryP M4LnWXNCVkeHUh?=
ES5 NUDoNHdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTVwMUK0Nlch|ryP M2\xdHNCVkeHUh?=
LoVo M17hcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTVwMUW4O|Eh|ryP MXXTRW5ITVJ?
SNU-387 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvXTWM2OD13LkOyN|M6KM7:TR?= MoDqV2FPT0WU
C8166 M3\S[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnLTWM2OD13LkO2N|M6KM7:TR?= NUnDXJliW0GQR1XS
LS-1034 M{m5Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2m2XGlEPTB;NT60NlMxPyEQvF2= NUXBVpBbW0GQR1XS
GR-ST NVXLXnFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUi0T4FGUUN3ME21MlUzOjBzIN88US=> M{HzOXNCVkeHUh?=
NCI-H1092 NHPNSpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTVwN{K4OFMh|ryP Ml7xV2FPT0WU
647-V MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jBdmlEPTB;NT63OFcxPiEQvF2= MnG3V2FPT0WU
EW-13 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnH[VlKSzVyPUWuO|Y3OjdizszN MXHTRW5ITVJ?
KGN MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXRR4NKSzVyPU[uNFk6OjFizszN NILmWGVUSU6JRWK=
D-423MG NGe1WYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVztSXF7UUN3ME22MlQxOjh2IN88US=> MWjTRW5ITVJ?
ECC10 NUfJZlVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvZPXJKSzVyPUeuNVAyODFizszN MkXnV2FPT0WU
TE-5 NIHw[FRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvLTWM2OD15LkSxNlk5KM7:TR?= M1WzTnNCVkeHUh?=
P12-ICHIKAWA NGC4UI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XFOGlEPTB;Nz60OVUzOyEQvF2= NGDIWIpUSU6JRWK=
NCI-H82 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGntdGJKSzVyPUeuOFU4ODFizszN M{\TXHNCVkeHUh?=
NCI-H1993 NGHkb49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTdwOEOwOlMh|ryP NGjs[VVUSU6JRWK=
RH-1 MkL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTdwOEWyOFQh|ryP MnHIV2FPT0WU
SW948 NH3jXI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\R[XpKSzVyPUeuPVYxPDlizszN MorRV2FPT0WU
CAL-33 NUXuPZc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYf0[HNUUUN3ME23Mlk6QTN6IN88US=> NYjjblNyW0GQR1XS
U-266 NWXIWG04T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4C4WmlEPTB;OD6xOVc4PyEQvF2= MYHTRW5ITVJ?
CAL-72 NYnDTVVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7tTWM2OD16LkKwN|Ih|ryP MoXOV2FPT0WU
SNU-423 NIfLZ4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTlwM{[2OlYh|ryP MULTRW5ITVJ?
KG-1 Ml;mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTlwNUi0OVYh|ryP MYnTRW5ITVJ?
HCC1395 MlK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XxcGlEPTB;OT65NlM2OiEQvF2= NELDS4NUSU6JRWK=
BE-13 NHLvNmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWW4WXlyUUN3ME2xNE45QDl{IN88US=> NITCTW9USU6JRWK=
MKN7 NU\UcJYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DSe2lEPTB;MUCuPVc3PSEQvF2= Ml:3V2FPT0WU
697 NEDtZWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3n6NGlEPTB;MUGuNVQ4OiEQvF2= MVnTRW5ITVJ?
LU-135 M3nYWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4C1XmlEPTB;MUGuNlMxPyEQvF2= M2Wxe3NCVkeHUh?=
ES7 MnXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjDOJFIUUN3ME2xNU4{OzF|IN88US=> NUnVV2NLW0GQR1XS
SK-HEP-1 NELjXpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XzXmlEPTB;MUGuO|Y1PiEQvF2= M3H4OHNCVkeHUh?=
BEN NXzsNo5GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPCTllKSzVyPUGxMlg2OSEQvF2= NIrzPGNUSU6JRWK=
NCI-H1770 NYjydIhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTF{LkGyOkDPxE1? MWjTRW5ITVJ?
SW13 NESxd2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGi2WWVKSzVyPUGyMlE2PDFizszN MXHTRW5ITVJ?
MZ1-PC M3fPRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHuxeohKSzVyPUGyMlU1PTJizszN MoPsV2FPT0WU
Mo-T NX3wTIVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXuTWM2OD1zMj63OFIyKM7:TR?= MXfTRW5ITVJ?
HLE Mo[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTF{LkiyNVUh|ryP NU\wV5FyW0GQR1XS
RCC10RGB NV;BN4Z6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzG[YtrUUN3ME2xN{43PzFizszN NEX6SVNUSU6JRWK=
COLO-320-HSR NWPWZ|JHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLrPG5KUUN3ME2xN{44OzhzIN88US=> M1G5WnNCVkeHUh?=
BHT-101 NYjJOXZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPMTWM2OD1zMz64N|Q2KM7:TR?= NXf4[lRsW0GQR1XS
OCUB-M MkC5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzlTWM2OD1zND6xOlAzKM7:TR?= M{\EOXNCVkeHUh?=
MEG-01 NU\aOGozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPwbI9KSzVyPUG0MlM4ODhizszN M17udXNCVkeHUh?=
RS4-11 NW\XSWdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTF2Lke0NkDPxE1? MV3TRW5ITVJ?
MN-60 MnnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWK1SnRKUUN3ME2xOE44QDl2IN88US=> Mke2V2FPT0WU
NCI-H1304 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDFbo5XUUN3ME2xOU4xPDJ3IN88US=> MXrTRW5ITVJ?
Ramos-2G6-4C10 M{[4S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPORWtKSzVyPUG1MlA2QDFizszN MYXTRW5ITVJ?
NCI-H2342 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTPN2hWUUN3ME2xOU4zODR2IN88US=> M2\T[3NCVkeHUh?=
LAN-6 M1LEPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkflTWM2OD1zNT60OFE1KM7:TR?= M4rUOHNCVkeHUh?=
JVM-2 NILSN|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTF3LkW3OFgh|ryP MnvlV2FPT0WU
P30-OHK NYf3RXMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfUTWM2OD1zNj6wOlE1KM7:TR?= MmPjV2FPT0WU
C-33-A M1fZemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzJWWRXUUN3ME2xOk43OjF2IN88US=> NWTId4g4W0GQR1XS
RPMI-8866 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPTRZBKSzVyPUG2Mlg1QTZizszN NYrwfXlrW0GQR1XS
NCI-H630 Mk\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\vTWM2OD1zNj64OVM4KM7:TR?= M4\xXHNCVkeHUh?=
KYSE-140 M{jYcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETnfXZKSzVyPUG3MlIxOjhizszN MWnTRW5ITVJ?
T84 Mk\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvEb3BtUUN3ME2xPE45Pjl3IN88US=> MV7TRW5ITVJ?
KU-19-19 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVntXIJDUUN3ME2xPE46PjB6IN88US=> NYjKV|ZwW0GQR1XS
BALL-1 M{\nTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTF7LkOzPVkh|ryP MVvTRW5ITVJ?
Calu-6 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTF7LkS5NkDPxE1? NVHrUVFGW0GQR1XS
EGI-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jvb2lEPTB;MUmuOVk5KM7:TR?= NULoN2plW0GQR1XS
MFH-ino MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PDZ2lEPTB;MUmuO|Q2PCEQvF2= MmC2V2FPT0WU
GB-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jNVGlEPTB;MkCuN|U{PSEQvF2= MVLTRW5ITVJ?
NCI-H1693 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTJyLk[1NFUh|ryP M2PGenNCVkeHUh?=
SW1116 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLFd5VGUUN3ME2yNE46OzZ{IN88US=> Ml;1V2FPT0WU
H-EMC-SS MnHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXuTWM2OD1{Mj6wOFUh|ryP M4rETHNCVkeHUh?=
D-502MG NUGyRnRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTJ{LkiyOlEh|ryP NGnyc25USU6JRWK=
IA-LM MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfDeVZKSzVyPUKzMlI1QTNizszN NGHK[HVUSU6JRWK=
SW1463 NXLSPIt2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEL5RZZKSzVyPUKzMlc6KM7:TR?= NHSwVJdUSU6JRWK=
JAR NVvn[GtST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojMTWM2OD1{ND6zNlk{KM7:TR?= NGTK[VJUSU6JRWK=
HT NW\1OppqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTJ2LkS3OVMh|ryP MYLTRW5ITVJ?
LCLC-103H MnnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml73TWM2OD1{ND64OFQ6KM7:TR?= M3;zTnNCVkeHUh?=
SNU-449 NXLNNnFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHnXYhRUUN3ME2yOE45PzRzIN88US=> MnTBV2FPT0WU
KE-37 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;4bnBKSzVyPUK1MlA6OjhizszN NIT1R3BUSU6JRWK=
NCI-H1623 NIH0SFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWqxeXBVUUN3ME2yO{4yOzB|IN88US=> NUf6dlBRW0GQR1XS
MOLT-13 NFLXNYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTJ5LkO1NVYh|ryP M1L4UHNCVkeHUh?=
COLO-741 NFj6cWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPvNIVLUUN3ME2zNU4{OzN|IN88US=> M4HpTHNCVkeHUh?=
NB6 M2XXPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTN{LkK4O|Yh|ryP M{C1ZnNCVkeHUh?=
MOLT-16 NF;l[5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;vTWM2OD1|Mz6wNFU2KM7:TR?= NGjCOnNUSU6JRWK=
IST-MES1 NUjKVZNkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1Lw[GlEPTB;M{SuNFU1OSEQvF2= M4DON3NCVkeHUh?=
A4-Fuk Ml;ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWewWY1mUUN3ME2zOU4xPjZizszN M2\1UHNCVkeHUh?=
CAL-85-1 NGXITphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIiwUIVKSzVyPUO1MlI5OTdizszN M{TBPHNCVkeHUh?=
CCRF-CEM NVHzVW1yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zINmlEPTB;M{euNVU{PiEQvF2= Mn7RV2FPT0WU
HAL-01 NILzbplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jPXGlEPTB;M{iuOFg5QSEQvF2= Ml3mV2FPT0WU
HEL M4T1NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTR|LkO0NFkh|ryP MlfyV2FPT0WU
EW-1 NIe0b4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTR|LkS3Olgh|ryP NIjEfnhUSU6JRWK=
MDA-MB-231 MlL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTR3LkGxPVkh|ryP NYe1VoxyW0GQR1XS
ABC-1 NEXNXZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4ezOGlEPTB;NE[uPFU{QCEQvF2= NI\BeGdUSU6JRWK=
NCI-H446 M2PP[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3q3bGlEPTB;NEiuOVA2QCEQvF2= MmjyV2FPT0WU
MHH-PREB-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7pUmZKSzVyPUS5MlYxODdizszN M4e1TnNCVkeHUh?=
DOHH-2 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nnTmlEPTB;NEmuOlY2PiEQvF2= M2rpW3NCVkeHUh?=
GCT MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFP2[odKSzVyPUS5MlY6PzZizszN M{fj[XNCVkeHUh?=

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

体内試験 17-AAG displays significantly higher binding affinity for Hsp90 from 3T3-src, B16 or CT26 xenografts in nude mice with IC50 values of 8-35 nM as compared with that from the normal tissues with IC50 values of 200-600 nM. [1] Administration of 17-AAG (~50 mg/kg) causes significant decline in AR, HER2, HER3, and Akt expression in a dose-dependent manner with >50% decline at dose of 50 mg/kg, resulting in the dose-dependent inhibition of androgen-dependent (CWR22) and -independent (CWR22R and CWRSA6) prostate cancer xenografts growth by 67%, 80% and 68% at dose of 50 mg/kg, respectively. [2]

お薦めの試験操作(参考用のみ)

キナーゼ試験:[1]
+ 展開

Hsp90 binding assays:

Purified native Hsp90 protein or cell lysates from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells in lysis buffer (20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl2, 100 mM KCl) are incubated with various concentrations of 17-AAG for 30 minutes at 4 °C, and then incubated with biotin-GM linked to BioMag streptavidin magnetic beads for 1 hour at 4 °C. Tubes are placed on a magnetic rack, and the unbound supernatant removed. The magnetic beads are washed three times in lysis buffer and heated for 5 minutes at 95 °C in SDS–PAGE sample buffer. Samples are analysed on SDS protein gels, and western blots done using indicated antibodies. Bands in the western blots are quantified using the Bio-rad Fluor-S MultiImager, and the percentage inhibition of binding of Hsp90 to the biotin-GM is calculated. The IC50 reported is the concentration of 17-AAG needed to cause half-maximal inhibition of binding.
細胞試験: [1]
+ 展開
  • 細胞株: BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, and PBMC cells
  • 濃度: Dissolved in DMSO, final concentrations ~10 μM
  • 反応時間: 5 days
  • 実験の流れ: Cells are seeded in 96-well plates at 2,000 cells per well in a final culture volume of 100 μL for 24 hours before the addition of increasing concentrations of 17-AAG that is incubated for 5 days. Viable cell number is determined using the Celltiter 96 AQueous Nonradioactive Cell Proliferation Assay. The value of the background absorbance at 490 nm (A490) of wells not containing cells is subtracted. Percentage of viable cells = (A490 of 17-AAG treated sample/A490 untreated cells) × 100. The IC50 is defined as the concentration that gave rise to 50% viable cell number.
    (参考用のみ)
動物試験:[2]
+ 展開
  • 動物モデル: Male nu/nu athymic mice inoculated s.c. with androgen-dependent CWR22 xenograft, and female nu/nu athymic mice inoculated s.c. with androgen-independent xenografts CWR22R and CWRSA6
  • 製剤: Dissolved in DMSO, and diluted in egg phospholipids (EPL) vehicle
  • 投薬量: ~50 mg/kg
  • 投与方法: Injection i.p.
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 100 mg/mL (170.73 mM)
Ethanol 5 mg/mL (8.53 mM)
Water Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
5%DMSO+corn oil
混合させたのち直ちに使用することを推奨します。
10mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 585.69
化学式

C31H43N3O8

CAS No. 75747-14-7
保管
in solvent
別名 CP127374,NSC-330507, KOS 953

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00577889 Completed Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage IV Pancreatic Cancer National Cancer Institute (NCI) March 2008 Phase 2
NCT00546780 Completed Multiple Myeloma Bristol-Myers Squibb February 2008 Phase 3
NCT00093496 Completed Primary Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer|Stage III Ovarian Epithelial Cancer|Stage IV Ovarian Epithelial Cancer National Cancer Institute (NCI) October 2007 Phase 2
NCT00514371 Completed Multiple Myeloma Bristol-Myers Squibb August 2007 Phase 2|Phase 3
NCT00779428 Completed Advanced Malignancies Bristol-Myers Squibb July 2006 Phase 2
NCT00354185 Terminated Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Post-transplant Lymphoproliferative Disorder|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Stage III Adult Burkitt Lymphoma|Stage III Adult Diffuse Large Cell Lymphoma|Stage III Adult Diffuse Mixed Cell Lymphoma|Stage III Adult Diffuse Small Cleaved Cell Lymphoma|Stage III Adult Hodgkin Lymphoma|Stage III Adult Immunoblastic Large Cell Lymphoma|Stage III Adult Lymphoblastic Lymphoma|Stage III Adult T-cell Leukemia/Lymphoma|Stage III Cutaneous T-cell Non-Hodgkin Lymphoma|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage III Marginal Zone Lymphoma|Stage III Mycosis Fungoides/Sezary Syndrome|Stage III Small Lymphocytic Lymphoma|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Mixed Cell Lymphoma|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Stage IV Adult Hodgkin Lymphoma|Stage IV Adult Immunoblastic Large Cell Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Adult T-cell Leukemia/Lymphoma|Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Mycosis Fungoides/Sezary Syndrome|Stage IV Small Lymphocytic Lymphoma|Unspecified Adult Solid Tumor Protocol Specific|Waldenström Macroglobulinemia National Cancer Institute (NCI) May 2006 Phase 1

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よくある質問(FAQ)

  • 質問1:

    What kind of subtypes does this compound inhibit? HSP90α or HSP90β ?

  • 回答:

    17-AAG can inhibit both HSP90α and HSP90β, but it is unclear how much are they affected respectively. You should note that Hsp90 derived from tumor cells has a 100-fold higher binding affinity for 17-AAG than that from normal cells according to this paper. http://www.nature.com.ezp-prod1.hul.harvard.edu/nature/journal/v425/n6956/full/nature01913.html

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