Tanespimycin (17-AAG)

製品コードS1141 別名：CP127374,NSC-330507, KOS 953

分子量(MW)：585.69

Tanespimycin (17-AAG) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.

サイズ

価格(税別)

10mM (in 1mL DMSO)	JPY 32370.00
25mg	JPY 24900.00
100mg	JPY 61420.00

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具体的な在庫状況を確認してください。代表番号: 03-5615-9297 | 電子メール：[email protected]

文献中Selleckの製品使用例(20)

カスタマーフィードバック(9)

(A) Cell lines were seeded in 96-well plates and treated with 10 nM of 17-AAG for 72 h. Cell survival was analyzed using CellTiter-Glo. Both parental H3122 cells (red bar) and H3122 CR cells (blue bar) show sensitivity to 17-AAG. (B) Suppression of ALK signaling by 17-AAG in resistant H3122 CR cells. H3122 parental and resistant cells were exposed to increasing concentrations of 17-AAG for 6 h.

PNAS, 2011, 108: 7535-40. Tanespimycin (17-AAG) purchased from Selleck.

(A) Treatment of DIPG cells with an HSP90 inhibitor, 17-AAG, resulted in decreased invasion toward SVZ hNPC CM at high doses. (B) Cell viability of DIPG cells treated with increasing doses of 17-AAG, by the CellTiter-Glo assay.

Cell, 2017, 170(5):845-859.e19. Tanespimycin (17-AAG) purchased from Selleck.
SKBR3 cells were treated with FW-04-806 at 10, 20, 40 uM for 24 h; 17AAG was used as a positive control at 1 and 2 uM. Hsp70, Hsp90, and Cdc37 protein level were analyzed with western blotting using relevant antibodies.

Mol Cancer 2014 13, 150. Tanespimycin (17-AAG) purchased from Selleck.

Western blot analysis of immunoprecipitated Hsp90/BIP complexes in MOLT-4 (T-ALL) and RS4;11 (B-ALL) treated for 22 h with CX-4945 (5 μM) and bortezomib (2.5 nM) either alone or in combination. 500 μg of protein lysates were immunoprecipitated with anti-Hsp90 antibody. Relative Induction values (Rel.Ind.) were obtained by normalizing to Hsp90 bands density. 17-AAG: tanespimycin.

Oncotarget, 2015, 51: S659-S660. Tanespimycin (17-AAG) purchased from Selleck.
Co-IP analyses of direct interaction between HSP90 and HIF-1α in 17-AAG (5 μM)-treated HSCs using antibodies against HSP90, HIF-1α or IgG (n = 2).

Br J Pharmacol, 2017, 174(5):409-423. Tanespimycin (17-AAG) purchased from Selleck.

Treatment with an Hsp90 inhibitor results in a dose-dependent decrease in complex IV activity. A, because Hsp90 levels were reduced by 80%, in PINK1 null dopaminergic neuronal cells, the effects of specific inhibition of Hsp90 using 17-AAG were analyzed in wild-type neuronal cells. Both complex IV activity and Hsp60 levels were decreased significantly in 17-AAG-treated cells in a dose-dependent manner. B, in contrast, 17-AAG treatment did not affect expression of Hsp90 and LRPPRC.

J Biol Chem 2012 287, 44109-20. Tanespimycin (17-AAG) purchased from Selleck.
UPR modulators destabilize mSmoM2. NIH 3T3 cells expressing mSmoM2 protein were treated with HSP90 inhibitors 17-AAG (50 uM and 100 uM) and SNX-2112 (25 uM and 50 uM) and the proteasome inhibitor bortezomib (25 uM and 50 uM) for 4 h prior to lysis. DMSO was the vehicle control. Western blotting of whole-cell lysates revealed mSmoM2 protein to be destabilized in response to HSP-90 inhibitors but not in response to bortezomib. Tubulin was the loading control. CHOP results indicate ER stress.

Mol Cell Biol 2013 33(12), 2375-87. Tanespimycin (17-AAG) purchased from Selleck.

Hsp90 is up-regulated during aging. Whole-cell extracts were prepared from young (PD 20) and old (PD 40) HFSN1 cells. c HFSN1 cells (PD 40) were treated with different concentration of the Hsp90 inhibitor (17-AAG) and then re-incubated for 24 h. Whole-cell extracts were prepared and analyzed by western blot using the indicated antibodies.

Age 2013 35, 549-62. Tanespimycin (17-AAG) purchased from Selleck.
Four types of the colon cancer cells with indicated K-Ras phenotype were incubated with indicated concentration of 17-AAG for 24 h, which were then analyzed for protein expression by WB.

Oncotarget 2014 5, 4269-82. Tanespimycin (17-AAG) purchased from Selleck.

製品安全説明書

HSP (e.g. HSP90)阻害剤の選択性比較

生物活性

製品説明

特性

Displays very low toxicity toward normal cells.

ターゲット

HSP90 ^[1]
(Cell-free assay)

5 nM

体外試験

17-AAG, an analog of geldanamycin, exhibits greater than 100 times higher binding affinity for Hsp90 derived from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells with IC50 values of 5-6 nM. ^[1] 17-AAG causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells such as LNCaP, LAPC-4, DU-145, and PC-3 with IC50 values of 25-45 nM. ^[2] In addition to inducing apoptosis of Ba/F3 cells transformed with wild-type BCR-ABL with an IC50 of 5.2 μM, 17-AAG has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively, by inducing the degradation of both wild-type BCR-ABL protein and mutants. ^[3]

細胞データ

Cell Lines	Assay Type	Activity Description	PMID
A549	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXvJR\|UxRTBwMECwN\|A{KM7:TR?=	MkLMV2FPT0WU
IST-MEL1	NIf3eXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHnNSWJKSzVyPUCuNFAxPDB5IN88US=>	MWLTRW5ITVJ?
NCI-SNU-1	NUHN[Gk3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1fMPGlEPTB;MD6wNFIxPyEQvF2=	NXLXcWc3W0GQR1XS
FADU	MnT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlrHTWM2OD1yLkCwNlA6KM7:TR?=	M{PFfXNCVkeHUh?=
C32	NH\1S3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXO0bnROUUN3ME2wMlAxOzB2IN88US=>	MWDTRW5ITVJ?
D-566MG	NYfscoROT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2HLO2lEPTB;MD6wNFM6KM7:TR?=	Mkn3V2FPT0WU
LXF-289	M2e0PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXTJR\|UxRTBwMEC0NVkh\|ryP	NX;FXJhbW0GQR1XS
HGC-27	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWDJR\|UxRTBwMEC1NUDPxE1?	M2nNe3NCVkeHUh?=
RPMI-7951	NVj2dZJRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mnj6TWM2OD1yLkCwO\|E4KM7:TR?=	MXrTRW5ITVJ?
HSC-3	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NI\IZ4RKSzVyPUCuNFA6OjlizszN	NXPFW4VXW0GQR1XS
MIA-PaCa-2	NVHMdmVGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF;DVYZKSzVyPUCuNFExODlizszN	MUnTRW5ITVJ?
KS-1	NIe4XpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYX3fGNUUUN3ME2wMlAyOzV3IN88US=>	M2n2c3NCVkeHUh?=
CAL-51	NIiy[YFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlLwTWM2OD1yLkCxOFA2KM7:TR?=	NEW2TpVUSU6JRWK=
MDA-MB-361	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIXxXnhKSzVyPUCuNFE1QTVizszN	M17ue3NCVkeHUh?=
TI-73	NGL5fVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoPiTWM2OD1yLkCxO\|k3KM7:TR?=	MX;TRW5ITVJ?
AGS	NH7SeGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXrYUo5tUUN3ME2wMlAyQTN6IN88US=>	NH2xS21USU6JRWK=
NCI-H460	NXjvUIRCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{XPN2lEPTB;MD6wNVk4PCEQvF2=	NWf2OZJTW0GQR1XS
A204	NWO1dGRXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2S5c2lEPTB;MD6wNlI1QSEQvF2=	NVPjblJKW0GQR1XS
CHL-1	NXX1b4hOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWTJR\|UxRTBwMEKyOVEh\|ryP	M17SR3NCVkeHUh?=
DU-4475	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEjxWndKSzVyPUCuNFIzPjFizszN	MYDTRW5ITVJ?
CGTH-W-1	M17mNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{PHPGlEPTB;MD6wNlM1QSEQvF2=	MkTVV2FPT0WU
HCC2218	NVLpSYhKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVXTWmlTUUN3ME2wMlAzPDl2IN88US=>	NYLmVnN[W0GQR1XS
A2780	MlTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXfJR\|UxRTBwMEK1N\|Eh\|ryP	MW\TRW5ITVJ?
NCI-H720	NY\uVnM{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFTweY9KSzVyPUCuNFI2PDZizszN	M37ER3NCVkeHUh?=
NCI-N87	MorsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIHKU5lKSzVyPUCuNFI2QTNizszN	NF;BWmFUSU6JRWK=
CHP-212	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2LD[mlEPTB;MD6wNlYzQCEQvF2=	NEC3cnVUSU6JRWK=
NCI-H23	MlXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVHJR\|UxRTBwMEK2OlUh\|ryP	NI\mOXZUSU6JRWK=
D-263MG	MnK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1z2N2lEPTB;MD6wNlc5PiEQvF2=	MlHJV2FPT0WU
ME-180	MlnTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXfKd5VtUUN3ME2wMlAzQDlzIN88US=>	MXzTRW5ITVJ?
SW982	NU\4emJuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHLoTlBKSzVyPUCuNFI6QTlizszN	NYLIZWRxW0GQR1XS
OE19	NXG3dpFyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoDiTWM2OD1yLkCzNFc4KM7:TR?=	NFOzOmtUSU6JRWK=
SK-LU-1	NULLOGFpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUTJR\|UxRTBwMEOwPFIh\|ryP	M1ruTHNCVkeHUh?=
H4	M3v1WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NETTTJJKSzVyPUCuNFMxQSEQvF2=	M3nqOHNCVkeHUh?=
HT-144	NIrlOohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGq5SmtKSzVyPUCuNFMxQTNizszN	NXnP[oNXW0GQR1XS
SK-UT-1	NEHJ[XNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH\UNGtKSzVyPUCuNFMyPzhizszN	M4\Fd3NCVkeHUh?=
D-336MG	MkKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4f2c2lEPTB;MD6wN\|MxQSEQvF2=	Mo\IV2FPT0WU
MDA-MB-175-VII	M4rOWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFzoZlRKSzVyPUCuNFM{PTRizszN	NFSyZWJUSU6JRWK=
GAMG	M{XJcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmjFTWM2OD1yLkCzOFM2KM7:TR?=	MlPWV2FPT0WU
CP50-MEL-B	M1TqcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFzPWZFKSzVyPUCuNFM1PSEQvF2=	M1PSVXNCVkeHUh?=
OVCAR-5	M{HRWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlL6TWM2OD1yLkCzOFgh\|ryP	NITqb2FUSU6JRWK=
SK-MES-1	MmnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVrJR\|UxRTBwMEO2NFYh\|ryP	NWjvfYw4W0GQR1XS
VM-CUB-1	M4S4Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX7OSHF1UUN3ME2wMlA{PjV5IN88US=>	MUTTRW5ITVJ?
WM-115	NIW2flhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWDJR\|UxRTBwMEO3OlIh\|ryP	MY\TRW5ITVJ?
DSH1	M4PNOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWDJR\|UxRTBwMEO4NFch\|ryP	M{e1NnNCVkeHUh?=
Becker	M3m2SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXjVenZPUUN3ME2wMlA{QDh3IN88US=>	MljrV2FPT0WU
SW962	MoLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoDBTWM2OD1yLkCzPVQ2KM7:TR?=	NEK4cVlUSU6JRWK=
TYK-nu	NFHlSXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MU\JR\|UxRTBwMEO5PFUh\|ryP	NFvNTXhUSU6JRWK=
HO-1-N-1	M4XyWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3ztdGlEPTB;MD6wOFAzOSEQvF2=	M2njOXNCVkeHUh?=
T98G	NGmwTVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NELnV5FKSzVyPUCuNFQyODNizszN	NX:zWnlkW0GQR1XS
ACN	NHu1T41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH\oRVhKSzVyPUCuNFQyPjJizszN	NVe3RpRVW0GQR1XS
SW780	M2ruNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXjJR\|UxRTBwMESyNFMh\|ryP	M3TiT3NCVkeHUh?=
Detroit562	M2DzTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1X3fmlEPTB;MD6wOFI{QSEQvF2=	MV;TRW5ITVJ?
BB49-HNC	NEjqeW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3TyN2lEPTB;MD6wOFI1OyEQvF2=	NHHsPItUSU6JRWK=
HN	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mni1TWM2OD1yLkC0NlczKM7:TR?=	NW[xZnViW0GQR1XS
H9	NUK4R2p3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NITMUWtKSzVyPUCuNFQ{PzFizszN	NF7tNlFUSU6JRWK=
VA-ES-BJ	NGW0boxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXrJR\|UxRTBwMES0OFch\|ryP	M2rEfXNCVkeHUh?=
MEL-JUSO	NGXTSmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUT4VWJKUUN3ME2wMlA1PDd3IN88US=>	M3LZOnNCVkeHUh?=
BT-474	M3LNRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4LlUGlEPTB;MD6wOFUh\|ryP	M3frXnNCVkeHUh?=
CaR-1	NWfjd\|c4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGPRbJFKSzVyPUCuNFQ2PDlizszN	MUDTRW5ITVJ?
PSN1	Mk\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH33OXRKSzVyPUCuNFQ3ODNizszN	NHjiPXVUSU6JRWK=
KYSE-510	NWDUVpVNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVXJR\|UxRTBwMES2OFkh\|ryP	MUjTRW5ITVJ?
KP-4	NHfkU\|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVW1O5NpUUN3ME2wMlA1PzV\|IN88US=>	M{TrPHNCVkeHUh?=
KYSE-410	MofVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NID2dFdKSzVyPUCuNFQ4PzJizszN	NETGTVJUSU6JRWK=
G-402	NGjFN5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MX;JR\|UxRTBwMES3PFkh\|ryP	NF;pW5hUSU6JRWK=
DOK	MlT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYPsOXpSUUN3ME2wMlA1QTB{IN88US=>	NUPSTWxvW0GQR1XS
COR-L88	M{X0TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnXhTWM2OD1yLkC0PVEzKM7:TR?=	MYHTRW5ITVJ?
SKG-IIIa	M37B[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{Hk[GlEPTB;MD6wOFk5PiEQvF2=	NH\jNWpUSU6JRWK=
AN3-CA	NXjDW4ZmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGTiXIJKSzVyPUCuNFUh\|ryP	MV\TRW5ITVJ?
SW48	NWm2fJhCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2\VWWlEPTB;MD6wOVA{QSEQvF2=	Ml7HV2FPT0WU
YKG-1	M{jw[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWXqflNzUUN3ME2wMlA2ODdzIN88US=>	MWrTRW5ITVJ?
KYSE-150	M4\IZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnHhTWM2OD1yLkC1NlM2KM7:TR?=	M3\HXHNCVkeHUh?=
HuO-3N1	NEjTdodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX:yfnpKUUN3ME2wMlA2OjN5IN88US=>	NWH3c2NxW0GQR1XS
LB1047-RCC	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWDJR\|UxRTBwMEWyPVYh\|ryP	M4jPbHNCVkeHUh?=
NCI-H2030	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYnJR\|UxRTBwMEW0NVQh\|ryP	M3O3V3NCVkeHUh?=
YH-13	NE\YSlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2fGVGlEPTB;MD6wOVczOiEQvF2=	MYHTRW5ITVJ?
5637	M2H0S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYjJR\|UxRTBwMEW3OEDPxE1?	M{W0UXNCVkeHUh?=
LOXIMVI	Mo\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3nyeWlEPTB;MD6wOVg4OiEQvF2=	NYfyd4tNW0GQR1XS
GT3TKB	NWjGR\|FET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MorKTWM2OD1yLkC1PVQzKM7:TR?=	NGq3dmFUSU6JRWK=
TCCSUP	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3\LbGlEPTB;MD6wOVk3PCEQvF2=	NYHHZ4ZRW0GQR1XS
EPLC-272H	NI\QNWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWnJR\|UxRTBwME[yNFUh\|ryP	Mlq4V2FPT0WU
LU-99A	M1PvVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXfxRYJpUUN3ME2wMlA3OjN5IN88US=>	MYHTRW5ITVJ?
NCI-H1755	NF7rU5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXG4flh5UUN3ME2wMlA3OzRzIN88US=>	M1TZXXNCVkeHUh?=
KM12	NYj5SmhnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUTkeXdvUUN3ME2wMlA3OzR6IN88US=>	NYO3ZnQ2W0GQR1XS
SF295	M1HVcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUH1UlUyUUN3ME2wMlA3PDV{IN88US=>	NX7OUG9OW0GQR1XS
MZ2-MEL	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3zoVWlEPTB;MD6wOlU2OyEQvF2=	MmnzV2FPT0WU
HEC-1	NFvyTJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVnJR\|UxRTBwME[1PFgh\|ryP	MkDzV2FPT0WU
SW684	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVPCbWZ3UUN3ME2wMlA3PTlzIN88US=>	NIG3[2NUSU6JRWK=
SF539	NUniT24{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUjJR\|UxRTBwME[2PFEh\|ryP	MmXjV2FPT0WU
GMS-10	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWDpNXRZUUN3ME2wMlA3Pjl7IN88US=>	M{DqdnNCVkeHUh?=
MV-4-11	NFfmPJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{fkVWlEPTB;MD6wOlgxOyEQvF2=	M3S1TnNCVkeHUh?=
HT-29	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWqzSoNIUUN3ME2wMlA3QTF7IN88US=>	MkD4V2FPT0WU
23132-87	MkTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mof0TWM2OD1yLkC2PVUh\|ryP	MWDTRW5ITVJ?
SW620	MkDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MojKTWM2OD1yLkC3NFI3KM7:TR?=	NV7Cc\|RyW0GQR1XS
HCC1806	NUnkZpN7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVzJR\|UxRTBwMEexN\|Eh\|ryP	MVjTRW5ITVJ?
Hs-578-T	NVTuWGxKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NISzUlNKSzVyPUCuNFczODhizszN	MkHoV2FPT0WU
A2058	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFvMXlFKSzVyPUCuNFczOjhizszN	NWXXTGVPW0GQR1XS
MEL-HO	NUHJZppqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHT5fIFKSzVyPUCuNFczPTVizszN	MU\TRW5ITVJ?
HCC2998	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4C2fmlEPTB;MD6wO\|M1PyEQvF2=	MmrQV2FPT0WU
HuO9	Mn\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYHQRVdHUUN3ME2wMlA4PTh7IN88US=>	NIrnR5FUSU6JRWK=
CAL-39	M1zMR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVT5Uo45UUN3ME2wMlA4PzZ4IN88US=>	M4\PW3NCVkeHUh?=
M14	Mm\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{TPOmlEPTB;MD6wO\|kyOyEQvF2=	NUX5U2ZEW0GQR1XS
BFTC-909	NUP0Z\|UzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV3ONmpSUUN3ME2wMlA4QTZ7IN88US=>	NG\aOXJUSU6JRWK=
TE-11	NITxbWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NG\UclhKSzVyPUCuNFc6QTZizszN	MoL4V2FPT0WU
TGBC1TKB	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnniTWM2OD1yLkC4NFQ{KM7:TR?=	M{Wwb3NCVkeHUh?=
L-363	NVHaZVI5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHjZN3FKSzVyPUCuNFgzODZizszN	MoO2V2FPT0WU
A431	NEO2R2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXzJR\|UxRTBwMEiyNUDPxE1?	MYnTRW5ITVJ?
MKN45	M1T4UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWO1VHFDUUN3ME2wMlA5OjF7IN88US=>	MkLkV2FPT0WU
HT-1080	NHXKSmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUH5clNYUUN3ME2wMlA5PDN7IN88US=>	Mn\xV2FPT0WU
OVCAR-8	NG\SNo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXL5T\|VyUUN3ME2wMlA5PjJ{IN88US=>	NXn2R2VMW0GQR1XS
LCLC-97TM1	MlXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV72XWtnUUN3ME2wMlA5PzJ6IN88US=>	MkXMV2FPT0WU
M059J	Mn:yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFXHSoVKSzVyPUCuNFkxOjdizszN	MY\TRW5ITVJ?
SK-MEL-2	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3zRPGlEPTB;MD6wPVA3KM7:TR?=	NFTP[FFUSU6JRWK=
TE-1	NXL5fGJLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIDkZY9KSzVyPUCuNFkzODRizszN	MX7TRW5ITVJ?
KYSE-180	NHPvR\|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mlq0TWM2OD1yLkC5NlYzKM7:TR?=	NYnwVXJEW0GQR1XS
D-247MG	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVzJR\|UxRTBwMEm0OVUh\|ryP	MUPTRW5ITVJ?
8-MG-BA	MlPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXnJR\|UxRTBwMEm0O\|Ih\|ryP	MYrTRW5ITVJ?
NCI-H1792	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlXFTWM2OD1yLkC5OlE5KM7:TR?=	NWHxdYZLW0GQR1XS
MCF7	MnXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlfZTWM2OD1yLkC5Olc4KM7:TR?=	NYTxcoczW0GQR1XS
NCI-H2122	NInSWWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlzyTWM2OD1yLkC5O\|Q2KM7:TR?=	NIrvbHlUSU6JRWK=
EFO-27	M{TMcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYPJR\|UxRTBwMEm5PVch\|ryP	MW\TRW5ITVJ?
LB2241-RCC	MoPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVrJR\|UxRTBwMUCwOVQh\|ryP	MkOxV2FPT0WU
SN12C	NUnRSlFIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{fsdGlEPTB;MD6xNFExPyEQvF2=	M4XSV3NCVkeHUh?=
A498	NYjkVVdiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{XRdGlEPTB;MD6xNFE5KM7:TR?=	NXfzemNiW0GQR1XS
PANC-03-27	M{W2cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MV7JR\|UxRTBwMUCyPFYh\|ryP	MV\TRW5ITVJ?
NCI-H1581	M1Ti[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVzJR\|UxRTBwMUCyPUDPxE1?	MXzTRW5ITVJ?
U-87-MG	M{foSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHjnR4dKSzVyPUCuNVA{ODdizszN	MlnjV2FPT0WU
G-401	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnHNTWM2OD1yLkGwN\|U{KM7:TR?=	NGK3XFdUSU6JRWK=
SiHa	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoL3TWM2OD1yLkGwOFg3KM7:TR?=	NXLrTnNwW0GQR1XS
U251	NHnPbmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEW1NJNKSzVyPUCuNVA2OjVizszN	NGrsU4lUSU6JRWK=
MMAC-SF	M3XBW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFPkNIRKSzVyPUCuNVA2OzFizszN	M2fEbXNCVkeHUh?=
BB65-RCC	NW[zN5U4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3mwRWlEPTB;MD6xNFU2PCEQvF2=	NGfsUZdUSU6JRWK=
NKM-1	M4XBOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYHNVphCUUN3ME2wMlExPjZ4IN88US=>	Mn\NV2FPT0WU
HD-MY-Z	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVjJR\|UxRTBwMUC4O\|Mh\|ryP	MoHyV2FPT0WU
TGBC11TKB	MmDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVmzNpJnUUN3ME2wMlExQTB\|IN88US=>	NUXnbHB2W0GQR1XS
COLO-679	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVjhXJBDUUN3ME2wMlEyOjFzIN88US=>	MnXNV2FPT0WU
TE-8	NFjqZW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4rXfWlEPTB;MD6xNVI3PCEQvF2=	MXHTRW5ITVJ?
SK-MEL-28	M{nhO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2npTGlEPTB;MD6xNVMzOSEQvF2=	MV\TRW5ITVJ?
SH-4	M3naW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX3pTVdVUUN3ME2wMlEyOzV4IN88US=>	MnTmV2FPT0WU
KALS-1	NF3OVoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NE\4eZBKSzVyPUCuNVE{QTNizszN	MWrTRW5ITVJ?
RKO	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYnnPVRQUUN3ME2wMlEyPzZ2IN88US=>	MlnyV2FPT0WU
OMC-1	M33ibmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVnsNIdVUUN3ME2wMlEyPzl5IN88US=>	NInidYZUSU6JRWK=
BT-549	NGK4R49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYTJR\|UxRTBwMUG3PVkh\|ryP	Mn61V2FPT0WU
NCI-H28	Mn;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUKx[XU6UUN3ME2wMlEyQDF5IN88US=>	Ml3OV2FPT0WU
RXF393	M33NWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHHZNIZKSzVyPUCuNVE6QDJizszN	MlfPV2FPT0WU
COLO-829	NUn6[XVqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mke2TWM2OD1yLkGyNFA2KM7:TR?=	NYfvU\|JSW0GQR1XS
HMV-II	M3zTXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUDJR\|UxRTBwMUKwNkDPxE1?	Mn2yV2FPT0WU
SW1990	MmPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUK1em97UUN3ME2wMlEzOTV5IN88US=>	NFrscYZUSU6JRWK=
NCI-H1437	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEDvUnFKSzVyPUCuNVIyPTdizszN	MV7TRW5ITVJ?
SNB75	M2PrRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MY\JR\|UxRTBwMUKxOlkh\|ryP	M3O5ZnNCVkeHUh?=
EW-3	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MknTTWM2OD1yLkGyOlYyKM7:TR?=	NV62OWI1W0GQR1XS
SAS	Mny5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1jE[GlEPTB;MD6xNlY6KM7:TR?=	NIXvUpJUSU6JRWK=
NCI-H1666	M17mU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mm\yTWM2OD1yLkGyO\|c1KM7:TR?=	MXzTRW5ITVJ?
A375	NX:1coU6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFu3OZRKSzVyPUCuNVI4PzhizszN	MVHTRW5ITVJ?
CAMA-1	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NF;6[WZKSzVyPUCuNVI6OjRizszN	NX3ES3lHW0GQR1XS
HuP-T4	NITXXVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUHJR\|UxRTBwMUK5OFMh\|ryP	NFS2VZZUSU6JRWK=
NCI-H292	NEXV[W1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV3JR\|UxRTBwMUOxNUDPxE1?	MUTTRW5ITVJ?
PC-14	M4XrTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3PjbmlEPTB;MD6xN\|IyOSEQvF2=	NFHZWGhUSU6JRWK=
BPH-1	NGXMUpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkTjTWM2OD1yLkGzOFEh\|ryP	MlrIV2FPT0WU
GAK	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{\WWWlEPTB;MD6xN\|U3PyEQvF2=	M{Pqe3NCVkeHUh?=
VMRC-RCZ	Mlr1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVTJR\|UxRTBwMUO3OlIh\|ryP	NXXTWmttW0GQR1XS
SK-MEL-24	NE\IPHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXLJR\|UxRTBwMUO4O{DPxE1?	NInuZ2ZUSU6JRWK=
LB831-BLC	NVO5XWZvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1HMZ2lEPTB;MD6xN\|g5OyEQvF2=	NW\TUo1sW0GQR1XS
NCI-H2452	NHfPXXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NITaXIlKSzVyPUCuNVM6PTZizszN	Mnv6V2FPT0WU
RT-112	NFezOZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYrRN5l2UUN3ME2wMlE1ODN3IN88US=>	NHvGO\|VUSU6JRWK=
GP5d	M2THS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGPXTZlKSzVyPUCuNVQyODRizszN	NVf6bpdlW0GQR1XS
LC-2-ad	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M13KO2lEPTB;MD6xOFEzOSEQvF2=	NVHJRWdPW0GQR1XS
MPP-89	NILyU3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlTSTWM2OD1yLkG0NVI2KM7:TR?=	MlzmV2FPT0WU
NUGC-3	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWPaSmxHUUN3ME2wMlE1PDd6IN88US=>	NWDZfHk4W0GQR1XS
GI-1	M3PxOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVzJR\|UxRTBwMUS1OVgh\|ryP	M3\BUXNCVkeHUh?=
HCC1419	MlnYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVTJR\|UxRTBwMUS1O\|Yh\|ryP	Mk\3V2FPT0WU
SW1573	NXy3dYhPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYTGTY9PUUN3ME2wMlE1PzV6IN88US=>	NVjQT2o{W0GQR1XS
NCI-H2347	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{W2cmlEPTB;MD6xOFg{QSEQvF2=	NVGwNFhVW0GQR1XS
Mewo	NUK1[2FmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoG4TWM2OD1yLkG0PFg6KM7:TR?=	MlzXV2FPT0WU
639-V	MlXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1XqUmlEPTB;MD6xOVAyOyEQvF2=	MnmxV2FPT0WU
AsPC-1	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3frW2lEPTB;MD6xOVIzPSEQvF2=	MoWwV2FPT0WU
NCI-H1648	NFXkfIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEjBWnpKSzVyPUCuNVUzOzJizszN	M1;DfXNCVkeHUh?=
786-0	NHzCdZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnrVTWM2OD1yLkG1N\|gyKM7:TR?=	MXLTRW5ITVJ?
ETK-1	MlfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Ml7aTWM2OD1yLkG1PUDPxE1?	NE\MZVdUSU6JRWK=
BxPC-3	M1\3Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnG0TWM2OD1yLkG1PVY3KM7:TR?=	M4fTNXNCVkeHUh?=
CAL-62	Mk[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3;3UGlEPTB;MD6xOlE3QSEQvF2=	NGLDT5JUSU6JRWK=
HCC1937	M4POZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFrEWlRKSzVyPUCuNVYzPzVizszN	NHq3W\|NUSU6JRWK=
NCI-H1299	NWDlcWU4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV\hOpZWUUN3ME2wMlE3Ojh3IN88US=>	M17K[nNCVkeHUh?=
SW1088	M2XRTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUHJR\|UxRTBwMU[0NVMh\|ryP	NEfGeIxUSU6JRWK=
FTC-133	NIDyXVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkK4TWM2OD1yLkG2OVQh\|ryP	M4fUUnNCVkeHUh?=
OC-314	NYjJeoRCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVfkZYw1UUN3ME2wMlE3PjlizszN	NHLmdXlUSU6JRWK=
SCC-9	NEfoSpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFvwcXZKSzVyPUCuNVY4OTZizszN	NGG5NGNUSU6JRWK=
HT-1376	M364R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M33NZmlEPTB;MD6xOlk{PiEQvF2=	NVjsVVhpW0GQR1XS
U-2-OS	M2P6V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVPJR\|UxRTBwMUexO\|Mh\|ryP	NY[4TndzW0GQR1XS
COLO-824	M4T1fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1[2dWlEPTB;MD6xO\|I6PCEQvF2=	NFi2[nJUSU6JRWK=
BB30-HNC	NUn6WGJRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHfmSXNKSzVyPUCuNVc{OyEQvF2=	NYnQ[INVW0GQR1XS
NCI-H2087	Mlf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWKxR3RHUUN3ME2wMlE4OzZ6IN88US=>	MlnUV2FPT0WU
NCI-H2170	MnL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NW\vWmN2UUN3ME2wMlE4PTN4IN88US=>	M{HlTnNCVkeHUh?=
SK-OV-3	NW\NWlN[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIi0eXRKSzVyPUCuNVc2PzFizszN	NHHISoZUSU6JRWK=
MZ7-mel	M3LyNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3j1cmlEPTB;MD6xO\|Y1QSEQvF2=	NWDyc3dSW0GQR1XS
NCI-H650	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFPOZXBKSzVyPUCuNVc3QDJizszN	MornV2FPT0WU
KOSC-2	NWLCeJpGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3O5fWlEPTB;MD6xO\|c{PCEQvF2=	NX;qXJp5W0GQR1XS
SCC-4	MnHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2LtdGlEPTB;MD6xO\|c4PyEQvF2=	NWHxco5sW0GQR1XS
MDA-MB-157	NHLPOmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NV3ENoUzUUN3ME2wMlE5ODh{IN88US=>	M2CzNnNCVkeHUh?=
KYSE-520	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4\SPGlEPTB;MD6xPFIh\|ryP	MmfOV2FPT0WU
LK-2	NVjTbZZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1jmSWlEPTB;MD6xPFMxOyEQvF2=	NVXVSItRW0GQR1XS
KNS-81-FD	NIS2dWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWfJR\|UxRTBwMUizPVQh\|ryP	MWXTRW5ITVJ?
IGROV-1	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{fKd2lEPTB;MD6xPFQ1OyEQvF2=	NYTJbVZUW0GQR1XS
DEL	MoHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVL4TZNEUUN3ME2wMlE5PDVizszN	MUHTRW5ITVJ?
NCI-H1395	M3rtNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVPJR\|UxRTBwMUi2PFIh\|ryP	MXvTRW5ITVJ?
JEG-3	NEG4WI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M17aN2lEPTB;MD6xPFcxPSEQvF2=	MkHGV2FPT0WU
BCPAP	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlPCTWM2OD1yLkG4PFczKM7:TR?=	MnLlV2FPT0WU
CAL-27	M{Phbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3XuZmlEPTB;MD6xPVAzOiEQvF2=	Ml3aV2FPT0WU
RD	M{XSPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVLi[IN1UUN3ME2wMlE6OTF\|IN88US=>	NGPJTYtUSU6JRWK=
RVH-421	NXrpfoQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV:z[HAxUUN3ME2wMlE6OTF4IN88US=>	MWjTRW5ITVJ?
Capan-2	NVTtd5A6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MX7JR\|UxRTBwMUmyOVYh\|ryP	MmC2V2FPT0WU
COLO-680N	M1jrVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHvTdVhKSzVyPUCuNVk{PjRizszN	MY\TRW5ITVJ?
NCI-H1650	M2Llbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkC5TWM2OD1yLkKwNFU4KM7:TR?=	NGn2VoJUSU6JRWK=
SBC-5	NVnUb4ZLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWHJR\|UxRTBwMkCxNVgh\|ryP	NIe3boZUSU6JRWK=
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DoTc2-4510	M4Tp[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVjXd3R4UUN3ME2wMlIxPzZ7IN88US=>	NX3QS\|ZnW0GQR1XS
AM-38	NX;tZZNOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MofETWM2OD1yLkKwPFQ5KM7:TR?=	M33EbHNCVkeHUh?=
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MFE-280	NFPCWWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{jRVmlEPTB;MD6yNVI6QCEQvF2=	MmjOV2FPT0WU
TE-9	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NILjfZFKSzVyPUCuNlE4QDZizszN	M2e3U3NCVkeHUh?=
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EoL-1-cell	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoTVTWM2OD1yLkKyNlA{KM7:TR?=	NYTmNm1XW0GQR1XS
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KYSE-270	NIjjPXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHLYdY5KSzVyPUCuNlMxQDRizszN	NGPMe3BUSU6JRWK=
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NCI-H747	MoLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlHwTWM2OD1yLkK0NVY6KM7:TR?=	NVHoNXB1W0GQR1XS
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CAPAN-1	MnPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NF\LUGxKSzVyPUCuNlQ4QDNizszN	NEPHSotUSU6JRWK=
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NCI-H1355	M4TtZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHS0RYlKSzVyPUCuNlgxPzRizszN	Ml\wV2FPT0WU
NCI-H1048	NXftNG91T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NET0XIhKSzVyPUCuNlg6PTZizszN	MkPNV2FPT0WU
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COLO-792	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUXl[XZDUUN3ME2wMlMyOjVzIN88US=>	Mn20V2FPT0WU
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ChaGo-K-1	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NV3GWYo5UUN3ME2wMlMyPzF3IN88US=>	MW\TRW5ITVJ?
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LB996-RCC	M4rDOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIX4TVFKSzVyPUCuN\|M3OTlizszN	MmfKV2FPT0WU
DMS-273	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUTJR\|UxRTBwM{O5NVYh\|ryP	NYfIOXo4W0GQR1XS
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NCI-H2405	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4LN[mlEPTB;MD6zOFY{OSEQvF2=	M1;SWXNCVkeHUh?=
NCI-H2228	MnP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEP4bZdKSzVyPUCuN\|U{PTdizszN	NUfa[3h3W0GQR1XS
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NCI-H1573	NILEO\|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYr2W3RoUUN3ME2wMlQ2PTZ7IN88US=>	MkHSV2FPT0WU
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ES3	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1nCZ2lEPTB;MD61PVEzPCEQvF2=	MYDTRW5ITVJ?
OVCAR-3	M{Pubmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2exU2lEPTB;MD61PVM1OSEQvF2=	NXTVXGpuW0GQR1XS
ACHN	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXXJR\|UxRTBwNkC1Olkh\|ryP	NW\oXoZoW0GQR1XS
SW872	NETmOoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVnsVZZvUUN3ME2wMlYxPzZ\|IN88US=>	MknOV2FPT0WU
CP66-MEL	NGC3cW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{HHUGlEPTB;MD62NFk3QSEQvF2=	MnO1V2FPT0WU
NCI-H661	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2\HNmlEPTB;MD62NVExPCEQvF2=	NVXFS3FCW0GQR1XS
UACC-893	NY\xZYVET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX;lb3ZOUUN3ME2wMlY{PjhzIN88US=>	Mn[0V2FPT0WU
JVM-3	NEfBPYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFHaSndKSzVyPUCuOlM5ODRizszN	NHLsd4JUSU6JRWK=
SF268	Mn;US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUHJR\|UxRTBwNkSzOFkh\|ryP	NXnlbnU6W0GQR1XS
OCI-AML2	NYjjTI94T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Ml;oTWM2OD1yLk[1N\|k4KM7:TR?=	M1\HTHNCVkeHUh?=
RPMI-8226	NXnFb3dUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MV;JR\|UxRTBwNk[zNlMh\|ryP	NWf0TmpmW0GQR1XS
MKN28	Ml20S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVHJR\|UxRTBwNk[2NlQh\|ryP	Mn73V2FPT0WU
MDA-MB-453	MljIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmPETWM2OD1yLk[3NVgh\|ryP	MYDTRW5ITVJ?
BV-173	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYruVYpxUUN3ME2wMlY5Pjd7IN88US=>	M1nsNHNCVkeHUh?=
NCI-H358	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV\JR\|UxRTBwNki3NlYh\|ryP	NUjJbGNuW0GQR1XS
NCI-H1651	MlnlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2TB[WlEPTB;MD63JO69VQ>?	NWXLfpZ7W0GQR1XS
MDA-MB-415	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVXSZ4t4UUN3ME2wMlcxQDJ7IN88US=>	MYrTRW5ITVJ?
8305C	NITVTGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYLVRXZyUUN3ME2wMlczPDl6IN88US=>	MWnTRW5ITVJ?
EFM-19	NHe3S3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWXJR\|UxRTBwN{O2O\|Eh\|ryP	NEfwSFBUSU6JRWK=
RERF-LC-MS	NH3zc2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NImwcYlKSzVyPUCuO\|Q3OTNizszN	MWfTRW5ITVJ?
A388	NH3MNFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnL2TWM2OD1yLke2OFY4KM7:TR?=	M3;4UHNCVkeHUh?=
GI-ME-N	M1XIdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGXVWY9KSzVyPUCuO\|czOzVizszN	MnftV2FPT0WU
IGR-1	NGTjfIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIHPZXZKSzVyPUCuO\|kxPDNizszN	NFXDUXZUSU6JRWK=
LNCaP-Clone-FGC	MoXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXrLdnN6UUN3ME2wMlgxODB2IN88US=>	MnrmV2FPT0WU
SK-MEL-3	M4jXUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGH2VolKSzVyPUCuPFE2ODhizszN	NXTVemViW0GQR1XS
UACC-257	M33M[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYDJR\|UxRTBwOEKyN\|Eh\|ryP	NEC0VmxUSU6JRWK=
OE33	M2TWTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlP6TWM2OD1yLki1NVAyKM7:TR?=	Mon0V2FPT0WU
QIMR-WIL	MlzMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4rkUWlEPTB;MD64OVE1OSEQvF2=	NWPvdWtyW0GQR1XS
NCI-H2009	MnTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoL0TWM2OD1yLki1N\|EyKM7:TR?=	M2fa[XNCVkeHUh?=
NCI-H522	NUnROnVHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUjFXlFQUUN3ME2wMlg4Pzh\|IN88US=>	Mkm2V2FPT0WU
Saos-2	NYHEdG1XT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGjBXJhKSzVyPUCuPFc5PzFizszN	NVK3PJV[W0GQR1XS
NB17	NX:3[4pbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWfVXZlkUUN3ME2wMlg5ODJ3IN88US=>	MWHTRW5ITVJ?
D-392MG	MkPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmjFTWM2OD1yLki5N\|U3KM7:TR?=	M2rFOnNCVkeHUh?=
SHP-77	MlS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{\MRmlEPTB;MD65NFQ5PSEQvF2=	MUfTRW5ITVJ?
SK-MEL-30	M2\BW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NV3kPVg4UUN3ME2wMlkyOTh3IN88US=>	NGLhe5pUSU6JRWK=
GCIY	NEnEOnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3vsU2lEPTB;MD65NVg1OyEQvF2=	MXvTRW5ITVJ?
HCC70	MlO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYPRdZZpUUN3ME2wMlkzODV7IN88US=>	MoDxV2FPT0WU
LU-65	M2DhfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVPJR\|UxRTBwOUK1PVEh\|ryP	MnSyV2FPT0WU
NCI-H1563	MonFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUTjfoVnUUN3ME2wMlk1QDZ3IN88US=>	MVPTRW5ITVJ?
KURAMOCHI	NYHtdHo1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M33IbWlEPTB;MD65OVE6OiEQvF2=	NXPLPZBVW0GQR1XS
PA-1	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NX;nPIQyUUN3ME2wMlk2PDJ2IN88US=>	M2TJdXNCVkeHUh?=
NOS-1	M4TLemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGHmUXdKSzVyPUCuPVc1QDlizszN	NGjuUFBUSU6JRWK=
NCI-H69	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWW3TJhPUUN3ME2wMlk4PjN2IN88US=>	NWLESYVmW0GQR1XS
KYSE-450	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoSwTWM2OD1yLkm4OlI3KM7:TR?=	MWPTRW5ITVJ?
8505C	NXmzW\|NNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlWzTWM2OD1yLkm5PVgzKM7:TR?=	MlfuV2FPT0WU
TGBC24TKB	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFXpVmdKSzVyPUGuNFAxQDRizszN	NUjoTIh{W0GQR1XS
PFSK-1	NEfjT2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYPJR\|UxRTFwMEG0Nlgh\|ryP	NFLRVWtUSU6JRWK=
EKVX	NIjUZoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFvJRpFKSzVyPUGuNFMyOjFizszN	NVjS[WRiW0GQR1XS
RCM-1	M4n1Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUfwRYlpUUN3ME2xMlA2PTB5IN88US=>	MmDtV2FPT0WU
SW900	M1TLeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2LqSGlEPTB;MT6wO\|g{KM7:TR?=	MX7TRW5ITVJ?
D-542MG	MlzMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1\W[mlEPTB;MT6wO\|g2PSEQvF2=	M{nWbnNCVkeHUh?=
SK-PN-DW	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIfU[o9KSzVyPUGuNVAxPTZizszN	MWLTRW5ITVJ?
NCI-H727	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlPFTWM2OD1zLkGwNVU1KM7:TR?=	NHnOS5lUSU6JRWK=
SW837	NF;LcnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmXuTWM2OD1zLkGwPVU1KM7:TR?=	MV;TRW5ITVJ?
BT-20	NHS0Xm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXHJR\|UxRTFwMUGyNFQh\|ryP	M1TPNXNCVkeHUh?=
RH-18	NVna[3UxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHO5UYdKSzVyPUGuNVMyODNizszN	MXLTRW5ITVJ?
TE-12	NUj1VXV2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlrFTWM2OD1zLkGzN\|M{KM7:TR?=	NILFZZFUSU6JRWK=
NB10	MkjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIHnSo9KSzVyPUGuNVM{PDRizszN	NITBZnFUSU6JRWK=
AU565	MkKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFzDenNKSzVyPUGuNVU6PzNizszN	M2Swb3NCVkeHUh?=
OAW-42	MkPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmTmTWM2OD1zLkG4N\|A3KM7:TR?=	NGiz[HdUSU6JRWK=
DJM-1	MmGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1fQOGlEPTB;MT6xPVg5OSEQvF2=	NXj4XZhbW0GQR1XS
HH	MliyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3O1cWlEPTB;MT6yN\|g{OSEQvF2=	MorzV2FPT0WU
LAMA-84	M3v5c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NH;3THNKSzVyPUGuNlc{QTRizszN	NF;VcVhUSU6JRWK=
KNS-42	NWrHT\|M2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVzyUJE3UUN3ME2xMlMxOjl4IN88US=>	NV70WIZZW0GQR1XS
NCI-H2052	Ml7ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2K4cGlEPTB;MT6zNFUxPyEQvF2=	MWXTRW5ITVJ?
MLMA	NF:xOFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml\STWM2OD1zLkOyOFA4KM7:TR?=	M2\EenNCVkeHUh?=
NB12	M1LWZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MW\JR\|UxRTFwM{W2N\|Yh\|ryP	NIHBUlFUSU6JRWK=
NCI-H1838	NHHWXGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mkj5TWM2OD1zLkO2N\|A3KM7:TR?=	NUjjZ2xOW0GQR1XS
NCI-H526	NV3M[VA3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUnLTI95UUN3ME2xMlM4QDV\|IN88US=>	MkL0V2FPT0WU
LS-123	M2Dl[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NF\FW3BKSzVyPUGuN\|kxQTRizszN	MkXlV2FPT0WU
HDLM-2	M4e1cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml3zTWM2OD1zLkO5NlcyKM7:TR?=	NWLJbZNyW0GQR1XS
MC-IXC	M3nremdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYjwRpk5UUN3ME2xMlQzOzdzIN88US=>	NVHLRZlwW0GQR1XS
HCT-15	NIDuRXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3TEbGlEPTB;MT60N\|A3QCEQvF2=	Mn\hV2FPT0WU
NCI-H596	NFz6OZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1jsTGlEPTB;MT60OVA3OSEQvF2=	MV;TRW5ITVJ?
ZR-75-30	M1;Fbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkP0TWM2OD1zLkS3NFgzKM7:TR?=	MnPHV2FPT0WU
A704	NXm0e4dmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYHJR\|UxRTFwNk[1OlMh\|ryP	NW\tPY5rW0GQR1XS
OVCAR-4	MojqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2GyZmlEPTB;MT62PVYxPyEQvF2=	M1TjTXNCVkeHUh?=
SW1417	M1G5SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mn\ETWM2OD1zLkeyPFQ6KM7:TR?=	NUK4VngyW0GQR1XS
CAS-1	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUTJR\|UxRTFwN{O5N\|Yh\|ryP	Ml;2V2FPT0WU
IST-SL1	M1zvcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEOySXpKSzVyPUGuO\|k4PTlizszN	MlrwV2FPT0WU
A253	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYPJR\|UxRTFwOEKyN\|kh\|ryP	NF7SUHlUSU6JRWK=
EW-16	NIjscVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFXa[pRKSzVyPUGuPFI5PzVizszN	NWS5cHAyW0GQR1XS
SK-NEP-1	NYnq[YxYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MW\JR\|UxRTFwOE[5PFgh\|ryP	NUDXZoF{W0GQR1XS
NCI-H226	NUHxPYhVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NH7afWlKSzVyPUGuPFk{PTlizszN	MlzzV2FPT0WU
HOP-92	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEDlV3FKSzVyPUGuPVYxQTlizszN	NVj3WnloW0GQR1XS
NCI-H441	MkLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGjzUGNKSzVyPUKuNFI{OzdizszN	MlfJV2FPT0WU
LU-139	NEDyUFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXO0OnRQUUN3ME2yMlA{OTF2IN88US=>	NIfPeoxUSU6JRWK=
SJRH30	NFzZNo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{L3ZWlEPTB;Mj6wOFI2OyEQvF2=	NFj6TmJUSU6JRWK=
MG-63	NW\YO45TT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4rIbmlEPTB;Mj6xOFEyOSEQvF2=	NXvvdXNLW0GQR1XS
NH-12	NFfiWXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHmyNI5KSzVyPUKuNVUxODZizszN	NI\kb\|ZUSU6JRWK=
NB7	NUWyVJUxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkCwTWM2OD1{LkG5Olc{KM7:TR?=	NYi3cFFOW0GQR1XS
LB771-HNC	MoOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWe3cFh7UUN3ME2yMlIxPTl3IN88US=>	MVrTRW5ITVJ?
HCC1569	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXjXXolXUUN3ME2yMlI1PTh\|IN88US=>	MWXTRW5ITVJ?
D-283MED	NUPYZo9NT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFvIPXZKSzVyPUKuNlQ4QDJizszN	MmX4V2FPT0WU
J-RT3-T3-5	NXjwV4F{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M37uSGlEPTB;Mj6yOVM2OSEQvF2=	NH7vR\|VUSU6JRWK=
ATN-1	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFrDb2xKSzVyPUKuN\|MxQDJizszN	MkjLV2FPT0WU
HCC1954	M1\EPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MofvTWM2OD1{LkO0OFA5KM7:TR?=	M1P6cXNCVkeHUh?=
SCC-15	NX;3XmFrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4f1N2lEPTB;Mj6zPVMyOiEQvF2=	MWPTRW5ITVJ?
COLO-668	MnPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHO4WFlKSzVyPUKuOFMzKM7:TR?=	M3\ofHNCVkeHUh?=
LB373-MEL-D	NEj0XGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGHZcnFKSzVyPUKuOVQ3PzdizszN	NWfCdFZQW0GQR1XS
no-10	Mne2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXXtdHE3UUN3ME2yMlU1QTR5IN88US=>	NUTZNG1bW0GQR1XS
HT-1197	M2rqbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIr5cHVKSzVyPUKuOlMyQDhizszN	M3zveXNCVkeHUh?=
DU-145	NXXXU253T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MULJR\|UxRTJwN{mxOlIh\|ryP	NYS5OlF[W0GQR1XS
SK-N-AS	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1fpN2lEPTB;Mj64OFY6OiEQvF2=	MlLCV2FPT0WU
MOLT-4	M1W4Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVTNSoVvUUN3ME2yMlg2OzJ{IN88US=>	NH3nNHFUSU6JRWK=
EW-22	MlniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH;oeIVKSzVyPUKuPVI5PDFizszN	MYLTRW5ITVJ?
DB	MmnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWnJR\|UxRTJwOUe3OVkh\|ryP	M1;TdHNCVkeHUh?=
HL-60	M3rxeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWLJR\|UxRTNwMESzO\|Yh\|ryP	M{WxZXNCVkeHUh?=
SK-N-DZ	NY\EbmdET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXfJR\|UxRTNwMEWwO\|Uh\|ryP	NYGwNmwyW0GQR1XS
NY	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVfJR\|UxRTNwMEi1OFIh\|ryP	MmX5V2FPT0WU
T47D	NITX[3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWHJR\|UxRTNwMUC1OVgh\|ryP	Mni1V2FPT0WU
NCI-H2029	M4q1Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmS2TWM2OD1\|LkKyOFc4KM7:TR?=	M{TldHNCVkeHUh?=
KARPAS-299	NHH2UWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoW5TWM2OD1\|LkK2NFI4KM7:TR?=	NX;Ye2puW0GQR1XS
KM-H2	MnuxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGLXOZpKSzVyPUOuN\|A3QCEQvF2=	MX3TRW5ITVJ?
CHP-134	M{Pafmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUTJR\|UxRTNwNEezPUDPxE1?	M1rIS3NCVkeHUh?=
22RV1	M{POdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3rBOGlEPTB;Mz60PVE3QCEQvF2=	MlvMV2FPT0WU
NB5	NX;GeZpsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mo[zTWM2OD1\|LkWwOlg6KM7:TR?=	MVPTRW5ITVJ?
CW-2	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NELNZZdKSzVyPUOuOVU{OTRizszN	NFXnR49USU6JRWK=
EFO-21	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NX\VR3U5UUN3ME2zMlU3QTRizszN	NX\KSGs3W0GQR1XS
HuH-7	NGq3XnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWLRPI9KUUN3ME2zMlU5PDF2IN88US=>	M{\DNHNCVkeHUh?=
ALL-PO	NVjxNW9KT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUnJR\|UxRTNwNkKzN\|Uh\|ryP	NXPvfHlyW0GQR1XS
EM-2	NVHQR\|hTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFzqSJZKSzVyPUOuOlkxOTFizszN	NHj6TlZUSU6JRWK=
KLE	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV7JR\|UxRTNwN{OwNlkh\|ryP	NUDJUmlvW0GQR1XS
NEC8	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnrnTWM2OD1\|LkmxPFA5KM7:TR?=	NUnYNYlTW0GQR1XS
KP-N-YN	M3rwXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUHJR\|UxRTNwOUO0O\|Yh\|ryP	M{DLNHNCVkeHUh?=
SK-MEL-1	NXqybY1UT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{m3OmlEPTB;ND6wN\|UyQCEQvF2=	M3y2Z3NCVkeHUh?=
CAL-54	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1TvRWlEPTB;ND6wOVkyKM7:TR?=	M3zWZnNCVkeHUh?=
MS-1	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHjOcJZKSzVyPUSuNVYyPTVizszN	MW\TRW5ITVJ?
NCI-H209	MnzpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXfJR\|UxRTRwMkm5PVkh\|ryP	Ml;iV2FPT0WU
NOMO-1	NFq0RVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV;JR\|UxRTRwM{KxN\|Eh\|ryP	NY\BVoxyW0GQR1XS
RPMI-2650	M1HUOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVvaNmloUUN3ME20MlM3OzJ5IN88US=>	MX\TRW5ITVJ?
NCI-H810	M3OxPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4DvTmlEPTB;ND6zPVc{PiEQvF2=	M2fsfnNCVkeHUh?=
Ca9-22	NF7FPIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MX;JR\|UxRTRwNEW2PVEh\|ryP	NX\YWHU{W0GQR1XS
ES4	MnqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV\JR\|UxRTRwNEewPVUh\|ryP	NUTqcYZDW0GQR1XS
ES6	Mn73S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIriS3pKSzVyPUSuOFk3PTdizszN	M3TIZXNCVkeHUh?=
DMS-114	M17PW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXHFXlRbUUN3ME20MlU1PjlzIN88US=>	NIjIOoJUSU6JRWK=
ONS-76	MoS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NG\v[HBKSzVyPUSuOVc6PSEQvF2=	NF;2SppUSU6JRWK=
K-562	NEDP[WRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEnWcJRKSzVyPUSuO\|M5OTRizszN	M3L6bnNCVkeHUh?=
MHH-NB-11	NIPC[2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXTJR\|UxRTRwN{W0OlEh\|ryP	M3W0enNCVkeHUh?=
Calu-3	NVHvTppqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mmr4TWM2OD12Lke4OVQ5KM7:TR?=	M1jwSHNCVkeHUh?=
HT55	Ml3nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1jWcGlEPTB;ND64OFU1PSEQvF2=	M4f4fnNCVkeHUh?=
SK-N-FI	M{HRO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NH7I[HVKSzVyPUSuPFUxODlizszN	M1GzN3NCVkeHUh?=
ES1	MniyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4DT[2lEPTB;ND64OlA2PyEQvF2=	M4myRXNCVkeHUh?=
SF126	MofVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUPzSpViUUN3ME20Mlk{OTh2IN88US=>	MmexV2FPT0WU
ES5	NGnaS5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEjuSoRKSzVyPUWuNVI1OjdizszN	MU\TRW5ITVJ?
LoVo	NEm0ToRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{nGNGlEPTB;NT6xOVg4OSEQvF2=	MmnQV2FPT0WU
SNU-387	NGKzXJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGrTOZNKSzVyPUWuN\|I{OzlizszN	NWHUdYt{W0GQR1XS
C8166	NE\hUJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1G1WmlEPTB;NT6zOlM{QSEQvF2=	NFLoUmVUSU6JRWK=
LS-1034	NULRVFZDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXrkXYJbUUN3ME21MlQzOzB5IN88US=>	MX\TRW5ITVJ?
GR-ST	MlH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHzEWopKSzVyPUWuOVIzODFizszN	M{XObnNCVkeHUh?=
NCI-H1092	M1qzTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX\4Z2JWUUN3ME21MlczQDR\|IN88US=>	Mn3SV2FPT0WU
647-V	Ml\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGnrT4ZKSzVyPUWuO\|Q4ODZizszN	MoizV2FPT0WU
EW-13	NYPhdIJGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV3BVHZtUUN3ME21Mlc3PjJ5IN88US=>	NIPSNVBUSU6JRWK=
KGN	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2jQN2lEPTB;Nj6wPVkzOSEQvF2=	M{jmXXNCVkeHUh?=
D-423MG	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFnsZXdKSzVyPU[uOFAzQDRizszN	NWraUZFMW0GQR1XS
ECC10	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUnJR\|UxRTdwMUCxNFEh\|ryP	MmHtV2FPT0WU
TE-5	MkjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUfJR\|UxRTdwNEGyPVgh\|ryP	MX\TRW5ITVJ?
P12-ICHIKAWA	M{W3Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml\hTWM2OD15LkS1OVI{KM7:TR?=	NVT5SHQ4W0GQR1XS
NCI-H82	MnL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MU\JR\|UxRTdwNEW3NFEh\|ryP	MYLTRW5ITVJ?
NCI-H1993	NF;NZYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXXJR\|UxRTdwOEOwOlMh\|ryP	M3zVW3NCVkeHUh?=
RH-1	MojOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHT4UIFKSzVyPUeuPFUzPDRizszN	MXHTRW5ITVJ?
SW948	MmPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVvJR\|UxRTdwOU[wOFkh\|ryP	Mn\vV2FPT0WU
CAL-33	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYfJR\|UxRTdwOUm5N\|gh\|ryP	NHHyZotUSU6JRWK=
U-266	M1:5SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUDJR\|UxRThwMUW3O\|ch\|ryP	MmnhV2FPT0WU
CAL-72	NWq5[GFWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmDCTWM2OD16LkKwN\|Ih\|ryP	NHG1TXhUSU6JRWK=
SNU-423	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVn5OoVLUUN3ME25MlM3PjZ4IN88US=>	NHqyNoZUSU6JRWK=
KG-1	Mlq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIi0d5VKSzVyPUmuOVg1PTZizszN	MUXTRW5ITVJ?
HCC1395	NFvTWohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkTMTWM2OD17LkmyN\|UzKM7:TR?=	NH;OeI9USU6JRWK=
BE-13	NITVbJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnHqTWM2OD1zMD64PFkzKM7:TR?=	MlnhV2FPT0WU
MKN7	M1jLVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnPwTWM2OD1zMD65O\|Y2KM7:TR?=	MYHTRW5ITVJ?
697	M4rLVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWHNNWlHUUN3ME2xNU4yPDd{IN88US=>	MYnTRW5ITVJ?
LU-135	MoDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1\sRWlEPTB;MUGuNlMxPyEQvF2=	NV;NeWlnW0GQR1XS
ES7	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIXzfYVKSzVyPUGxMlM{OTNizszN	M2T1PHNCVkeHUh?=
SK-HEP-1	NH;zdndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUXJR\|UxRTFzLke2OFYh\|ryP	MVnTRW5ITVJ?
BEN	NXvGbGhrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mo\UTWM2OD1zMT64OVEh\|ryP	NUTabFF6W0GQR1XS
NCI-H1770	NVvaZXR2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnjBTWM2OD1zMj6xNlYh\|ryP	MXrTRW5ITVJ?
SW13	MkjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlnUTWM2OD1zMj6xOVQyKM7:TR?=	MYfTRW5ITVJ?
MZ1-PC	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4myVGlEPTB;MUKuOVQ2OiEQvF2=	MnroV2FPT0WU
Mo-T	Mk\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHyxd5RKSzVyPUGyMlc1OjFizszN	NYfaSZZnW0GQR1XS
HLE	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXjSTot{UUN3ME2xNk45OjF3IN88US=>	MnzHV2FPT0WU
RCC10RGB	M1fmb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUDJR\|UxRTF\|Lk[3NUDPxE1?	NWHJdng3W0GQR1XS
COLO-320-HSR	NUfUUlR[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlHaTWM2OD1zMz63N\|gyKM7:TR?=	Ml;qV2FPT0WU
BHT-101	NYPuW4RlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVPJR\|UxRTF\|LkizOFUh\|ryP	NF3JWolUSU6JRWK=
OCUB-M	M{LkW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmT6TWM2OD1zND6xOlAzKM7:TR?=	M4TyUHNCVkeHUh?=
MEG-01	MlPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlnETWM2OD1zND6zO\|A5KM7:TR?=	NFS0WI9USU6JRWK=
RS4-11	NFvY[oNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmqzTWM2OD1zND63OFIh\|ryP	NXH0VG5xW0GQR1XS
MN-60	M17icGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXPJR\|UxRTF2Lke4PVQh\|ryP	Ml7jV2FPT0WU
NCI-H1304	NU[4TG5WT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX:5T2dvUUN3ME2xOU4xPDJ3IN88US=>	NIfYNGZUSU6JRWK=
Ramos-2G6-4C10	Mn3LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MY\JR\|UxRTF3LkC1PFEh\|ryP	MkT6V2FPT0WU
NCI-H2342	M3LzVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWjJR\|UxRTF3LkKwOFQh\|ryP	MorNV2FPT0WU
LAN-6	MlLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWjyeXFrUUN3ME2xOU41PDF2IN88US=>	MVzTRW5ITVJ?
JVM-2	M4SwNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3XNXGlEPTB;MUWuOVc1QCEQvF2=	NInzRmxUSU6JRWK=
P30-OHK	MoGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH\BVXFKSzVyPUG2MlA3OTRizszN	MmDyV2FPT0WU
C-33-A	NVfi[pFqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYXJR\|UxRTF4Lk[yNVQh\|ryP	MmPnV2FPT0WU
RPMI-8866	Mn3SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV3JR\|UxRTF4Lki0PVYh\|ryP	M4LqVXNCVkeHUh?=
NCI-H630	MkK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2Ky[mlEPTB;MU[uPFU{PyEQvF2=	MnzBV2FPT0WU
KYSE-140	NX3rUpJTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUTJR\|UxRTF5LkKwNlgh\|ryP	M1XiWHNCVkeHUh?=
T84	MoriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnvJTWM2OD1zOD64Olk2KM7:TR?=	NH60NVNUSU6JRWK=
KU-19-19	MmjtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUi5UGlHUUN3ME2xPE46PjB6IN88US=>	MlLKV2FPT0WU
BALL-1	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYXJR\|UxRTF7LkOzPVkh\|ryP	NFfaR3dUSU6JRWK=
Calu-6	NV[zW2dlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGTtWY1KSzVyPUG5MlQ6OiEQvF2=	NWLWbYFpW0GQR1XS
EGI-1	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXTJR\|UxRTF7LkW5PEDPxE1?	MnvIV2FPT0WU
MFH-ino	NGftcHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUXJR\|UxRTF7Lke0OVQh\|ryP	Mn71V2FPT0WU
GB-1	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUHnO2dnUUN3ME2yNE4{PTN3IN88US=>	NFPHPVFUSU6JRWK=
NCI-H1693	NY\INHNIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoDaTWM2OD1{MD62OVA2KM7:TR?=	NU\RdY0{W0GQR1XS
SW1116	NITibZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFrlN49KSzVyPUKwMlk{PjJizszN	M4jERnNCVkeHUh?=
H-EMC-SS	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEPLSVRKSzVyPUKyMlA1PSEQvF2=	MmrjV2FPT0WU
D-502MG	M2DmVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHTUUlZKSzVyPUKyMlgzPjFizszN	NI\1[JZUSU6JRWK=
IA-LM	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3rnXmlEPTB;MkOuNlQ6OyEQvF2=	M4XBNXNCVkeHUh?=
SW1463	MkT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn7RTWM2OD1{Mz63PUDPxE1?	M4XOW3NCVkeHUh?=
JAR	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIf5eI5KSzVyPUK0MlMzQTNizszN	MVrTRW5ITVJ?
HT	MmPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUDJR\|UxRTJ2LkS3OVMh\|ryP	M2jBfXNCVkeHUh?=
LCLC-103H	M{Oxfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXnJR\|UxRTJ2Lki0OFkh\|ryP	Mo\lV2FPT0WU
SNU-449	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NE\mT3lKSzVyPUK0Mlg4PDFizszN	M3PWOHNCVkeHUh?=
KE-37	Mn[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUnXWHYyUUN3ME2yOU4xQTJ6IN88US=>	M1\kUnNCVkeHUh?=
NCI-H1623	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXXJR\|UxRTJ5LkGzNFMh\|ryP	M{XYRnNCVkeHUh?=
MOLT-13	MmHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYHESYhpUUN3ME2yO{4{PTF4IN88US=>	NGnSbGRUSU6JRWK=
COLO-741	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUHJR\|UxRTNzLkOzN\|Mh\|ryP	MXzTRW5ITVJ?
NB6	M4LEUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXXJR\|UxRTN{LkK4O\|Yh\|ryP	NGDTcm1USU6JRWK=
MOLT-16	MnTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NF7QTpNKSzVyPUOzMlAxPTVizszN	MXrTRW5ITVJ?
IST-MES1	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXHJR\|UxRTN2LkC1OFEh\|ryP	M3\FVXNCVkeHUh?=
A4-Fuk	NH6x[mxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYLJR\|UxRTN3LkC2OkDPxE1?	MmTuV2FPT0WU
CAL-85-1	M4fEVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NF3rNm5KSzVyPUO1MlI5OTdizszN	NIPQfIlUSU6JRWK=
CCRF-CEM	NEXxOYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3TMXmlEPTB;M{euNVU{PiEQvF2=	MXLTRW5ITVJ?
HAL-01	MlLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MX3JR\|UxRTN6LkS4PFkh\|ryP	MlixV2FPT0WU
HEL	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NG\6eWlKSzVyPUSzMlM1ODlizszN	NUHycW94W0GQR1XS
EW-1	NHX4NIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWLJflBXUUN3ME20N{41PzZ6IN88US=>	MXLTRW5ITVJ?
MDA-MB-231	NFnvfJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkCyTWM2OD12NT6xNVk6KM7:TR?=	M{TYN3NCVkeHUh?=
ABC-1	M1vvd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGn2W4pKSzVyPUS2Mlg2OzhizszN	NEXDc5RUSU6JRWK=
NCI-H446	Ml\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH;UcGlKSzVyPUS4MlUxPThizszN	NGHtPVNUSU6JRWK=
MHH-PREB-1	NFPVUGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2L4b2lEPTB;NEmuOlAxPyEQvF2=	NH;hdXdUSU6JRWK=
DOHH-2	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEPt[IxKSzVyPUS5MlY3PTZizszN	NELYOm1USU6JRWK=
GCT	NUjFT4dIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1rSfmlEPTB;NEmuOlk4PiEQvF2=	MoHHV2FPT0WU

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体内試験

17-AAG displays significantly higher binding affinity for Hsp90 from 3T3-src, B16 or CT26 xenografts in nude mice with IC50 values of 8-35 nM as compared with that from the normal tissues with IC50 values of 200-600 nM. ^[1] Administration of 17-AAG (~50 mg/kg) causes significant decline in AR, HER2, HER3, and Akt expression in a dose-dependent manner with >50% decline at dose of 50 mg/kg, resulting in the dose-dependent inhibition of androgen-dependent (CWR22) and -independent (CWR22R and CWRSA6) prostate cancer xenografts growth by 67%, 80% and 68% at dose of 50 mg/kg, respectively. ^[2]

お薦めの試験操作（参考用のみ）

キナーゼ試験：^[1]	+ 展開 Hsp90 binding assays: Purified native Hsp90 protein or cell lysates from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells in lysis buffer (20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl₂, 100 mM KCl) are incubated with various concentrations of 17-AAG for 30 minutes at 4 °C, and then incubated with biotin-GM linked to BioMag streptavidin magnetic beads for 1 hour at 4 °C. Tubes are placed on a magnetic rack, and the unbound supernatant removed. The magnetic beads are washed three times in lysis buffer and heated for 5 minutes at 95 °C in SDS–PAGE sample buffer. Samples are analysed on SDS protein gels, and western blots done using indicated antibodies. Bands in the western blots are quantified using the Bio-rad Fluor-S MultiImager, and the percentage inhibition of binding of Hsp90 to the biotin-GM is calculated. The IC50 reported is the concentration of 17-AAG needed to cause half-maximal inhibition of binding.
細胞試験： ^[1]	+ 展開細胞株： BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, and PBMC cells 濃度： Dissolved in DMSO, final concentrations ~10 μM 反応時間： 5 days 実験の流れ： Cells are seeded in 96-well plates at 2,000 cells per well in a final culture volume of 100 μL for 24 hours before the addition of increasing concentrations of 17-AAG that is incubated for 5 days. Viable cell number is determined using the Celltiter 96 AQueous Nonradioactive Cell Proliferation Assay. The value of the background absorbance at 490 nm (A₄₉₀) of wells not containing cells is subtracted. Percentage of viable cells = (A₄₉₀ of 17-AAG treated sample/A₄₉₀ untreated cells) × 100. The IC50 is defined as the concentration that gave rise to 50% viable cell number. (参考用のみ)
動物試験：^[2]	+ 展開動物モデル： Male nu/nu athymic mice inoculated s.c. with androgen-dependent CWR22 xenograft, and female nu/nu athymic mice inoculated s.c. with androgen-independent xenografts CWR22R and CWRSA6 製剤： Dissolved in DMSO, and diluted in egg phospholipids (EPL) vehicle 投薬量： ~50 mg/kg 投与方法： Injection i.p. (参考用のみ)

参考

溶解度 (25°C)

体外	DMSO	100 mg/mL (170.73 mM)
	Ethanol	5 mg/mL (8.53 mM)
	Water	Insoluble
体内	左から（NMPから）右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ): 5%DMSO+corn oil 混合させたのち直ちに使用することを推奨します。	10mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報 Tanespimycin (17-AAG) SDFをダウンロードする

分子量	585.69
化学式	C₃₁H₄₃N₃O₈
CAS No.	75747-14-7
保管	3年 -20°C 粉
保管	2年 -80°C in solvent
別名	CP127374,NSC-330507, KOS 953

便利ツール

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

質量

濃度

体積

分子量
=

×

×

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA（製品ページで利用可能な）。

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます：

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます：C1V1 = C2V2 ( 入力出力 )

C1

V1

C2

V2
×

=

×

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA（オンラインで利用できる）で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

連続希釈剤
初めの濃度：
稀釈倍数：

計算結果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください：

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量	濃度	体積	分子量
=	×	×

臨床試験 (data from https://clinicaltrials.gov, updated on 2019-03-27)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT00577889	Completed	Adenocarcinoma of the Pancreas\|Recurrent Pancreatic Cancer\|Stage IV Pancreatic Cancer	National Cancer Institute (NCI)	March 2008	Phase 2
NCT00577889	Completed	Adenocarcinoma of the Pancreas\|Recurrent Pancreatic Cancer\|Stage IV Pancreatic Cancer	National Cancer Institute (NCI)	March 2008	Phase 2
NCT00546780	Completed	Multiple Myeloma	Bristol-Myers Squibb	February 2008	Phase 3
NCT00546780	Completed	Multiple Myeloma	Bristol-Myers Squibb	February 2008	Phase 3
NCT00093496	Completed	Primary Peritoneal Cavity Cancer\|Recurrent Ovarian Epithelial Cancer\|Stage III Ovarian Epithelial Cancer\|Stage IV Ovarian Epithelial Cancer	National Cancer Institute (NCI)	October 2007	Phase 2
NCT00093496	Completed	Primary Peritoneal Cavity Cancer\|Recurrent Ovarian Epithelial Cancer\|Stage III Ovarian Epithelial Cancer\|Stage IV Ovarian Epithelial Cancer	National Cancer Institute (NCI)	October 2007	Phase 2

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

よくある質問（FAQ）

質問1：
What kind of subtypes does this compound inhibit? HSP90α or HSP90β ?
回答：
17-AAG can inhibit both HSP90α and HSP90β, but it is unclear how much are they affected respectively. You should note that Hsp90 derived from tumor cells has a 100-fold higher binding affinity for 17-AAG than that from normal cells according to this paper. http://www.nature.com.ezp-prod1.hul.harvard.edu/nature/journal/v425/n6956/full/nature01913.html

HSP (e.g. HSP90)シグナル伝達経路

HSP (e.g. HSP90) Inhibitors with Unique Features

Selective HSP90 Inhibitor

NVP-BEP800 : HSP90β-selective, IC50=58 nM.
Most Potent HSP90 Inhibitor

KW-2478 : HSP90, IC50=3.8 nM.
HSP90 Inhibitor in Clinical Trial

17-DMAG (Alvespimycin) HCl : Phase II for Kidney Cancer.
Newest HSP90 Inhibitor

XL888 : ATP-competitive inhibitor of HSP90 with IC50 of 24 nM.

相関HSP (e.g. HSP90)製品

PU-H71

PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM. Phase 1.
KNK437

KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.
FRAX597

FRAX597 is a potent, ATP-competitive inhibitor of group I PAKs with IC50 of 8 nM, 13 nM, and 19 nM for PAK1, PAK2, and PAK3, respectively.
Luminespib (AUY-922, NVP-AUY922)

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
Ganetespib (STA-9090)

Ganetespib (STA-9090) is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells, induces apoptosis of OSA cells while normal osteoblasts are not affected; active metabolite of STA-1474. Phase 3.
Alvespimycin (17-DMAG) HCl

Alvespimycin (17-DMAG) HCl is a potent HSP90 inhibitor with IC50 of 62 nM in a cell-free assay. Phase 2.

Features:A synthetic derivative Geldanamycin, with lower hepatotoxicity than parent antibiotic & higher potency and bioavailability than the similar derivative 17-AAG.
Geldanamycin

Geldanamycin is a natural existing HSP90 inhibitor with K_d of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association.

研究分野別

製品類型

Tanespimycin (17-AAG)

文献中Selleckの製品使用例(20)

カスタマーフィードバック(9)

製品安全説明書

HSP (e.g. HSP90)阻害剤の選択性比較

生物活性

お薦めの試験操作（参考用のみ）

参考

溶解度 (25°C)

化学情報 Tanespimycin (17-AAG) SDFをダウンロードする

便利ツール

モル濃度計算器

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

希釈計算器

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

連続希釈計算器方程式

連続希釈剤

計算結果

分子量计算器

総分子量：g/mol

モル濃度計算器

臨床試験 (data from https://clinicaltrials.gov, updated on 2019-03-27)

技術サポート

よくある質問（FAQ）

HSP (e.g. HSP90)シグナル伝達経路

HSP (e.g. HSP90) Inhibitors with Unique Features

相関HSP (e.g. HSP90)製品