Tanespimycin (17-AAG)

製品コードS1141 別名:CP127374,NSC-330507, KOS 953

Tanespimycin (17-AAG)化学構造

分子量(MW):585.69

Tanespimycin (17-AAG) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.

サイズ 価格(税別)  
JPY 32370.00
JPY 24900.00
JPY 61420.00

カスタマーフィードバック(9)

  • (A) Cell lines were seeded in 96-well plates and treated with 10 nM of 17-AAG for 72 h. Cell survival was analyzed using CellTiter-Glo. Both parental H3122 cells (red bar) and H3122 CR cells (blue bar) show sensitivity to 17-AAG. (B) Suppression of ALK signaling by 17-AAG in resistant H3122 CR cells. H3122 parental and resistant cells were exposed to increasing concentrations of 17-AAG for 6 h.

    PNAS, 2011, 108: 7535-40. Tanespimycin (17-AAG) purchased from Selleck.

    (A) Treatment of DIPG cells with an HSP90 inhibitor, 17-AAG, resulted in decreased invasion toward SVZ hNPC CM at high doses. (B) Cell viability of DIPG cells treated with increasing doses of 17-AAG, by the CellTiter-Glo assay.

    Cell, 2017, 170(5):845-859.e19. Tanespimycin (17-AAG) purchased from Selleck.

  • SKBR3 cells were treated with FW-04-806 at 10, 20, 40 uM for 24 h; 17AAG was used as a positive control at 1 and 2 uM. Hsp70, Hsp90, and Cdc37 protein level were analyzed with western blotting using relevant antibodies.

    Mol Cancer 2014 13, 150. Tanespimycin (17-AAG) purchased from Selleck.

    Western blot analysis of immunoprecipitated Hsp90/BIP complexes in MOLT-4 (T-ALL) and RS4;11 (B-ALL) treated for 22 h with CX-4945 (5 μM) and bortezomib (2.5 nM) either alone or in combination. 500 μg of protein lysates were immunoprecipitated with anti-Hsp90 antibody. Relative Induction values (Rel.Ind.) were obtained by normalizing to Hsp90 bands density. 17-AAG: tanespimycin.

    Oncotarget, 2015, 51: S659-S660. Tanespimycin (17-AAG) purchased from Selleck.

  • Co-IP analyses of direct interaction between HSP90 and HIF-1α in 17-AAG (5 μM)-treated HSCs using antibodies against HSP90, HIF-1α or IgG (n = 2).

    Br J Pharmacol, 2017, 174(5):409-423. Tanespimycin (17-AAG) purchased from Selleck.

    Treatment with an Hsp90 inhibitor results in a dose-dependent decrease in complex IV activity. A, because Hsp90 levels were reduced by 80%, in PINK1 null dopaminergic neuronal cells, the effects of specific inhibition of Hsp90 using 17-AAG were analyzed in wild-type neuronal cells. Both complex IV activity and Hsp60 levels were decreased significantly in 17-AAG-treated cells in a dose-dependent manner. B, in contrast, 17-AAG treatment did not affect expression of Hsp90 and LRPPRC.

    J Biol Chem 2012 287, 44109-20. Tanespimycin (17-AAG) purchased from Selleck.

  • UPR modulators destabilize mSmoM2. NIH 3T3 cells expressing mSmoM2 protein were treated with HSP90 inhibitors 17-AAG (50 uM and 100 uM) and SNX-2112 (25 uM and 50 uM) and the proteasome inhibitor bortezomib (25 uM and 50 uM) for 4 h prior to lysis. DMSO was the vehicle control. Western blotting of whole-cell lysates revealed mSmoM2 protein to be destabilized in response to HSP-90 inhibitors but not in response to bortezomib. Tubulin was the loading control. CHOP results indicate ER stress.

    Mol Cell Biol 2013 33(12), 2375-87. Tanespimycin (17-AAG) purchased from Selleck.

    Hsp90 is up-regulated during aging. Whole-cell extracts were prepared from young (PD 20) and old (PD 40) HFSN1 cells. c HFSN1 cells (PD 40) were treated with different concentration of the Hsp90 inhibitor (17-AAG) and then re-incubated for 24 h. Whole-cell extracts were prepared and analyzed by western blot using the indicated antibodies.

    Age 2013 35, 549-62. Tanespimycin (17-AAG) purchased from Selleck.

  • Four types of the colon cancer cells with indicated K-Ras phenotype were incubated with indicated concentration of 17-AAG for 24 h, which were then analyzed for protein expression by WB.

    Oncotarget 2014 5, 4269-82. Tanespimycin (17-AAG) purchased from Selleck.

製品安全説明書

HSP (e.g. HSP90)阻害剤の選択性比較

生物活性

製品説明 Tanespimycin (17-AAG) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.
特性 Displays very low toxicity toward normal cells.
ターゲット
HSP90 [1]
(Cell-free assay)
5 nM
体外試験

17-AAG, an analog of geldanamycin, exhibits greater than 100 times higher binding affinity for Hsp90 derived from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells with IC50 values of 5-6 nM. [1] 17-AAG causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells such as LNCaP, LAPC-4, DU-145, and PC-3 with IC50 values of 25-45 nM. [2] In addition to inducing apoptosis of Ba/F3 cells transformed with wild-type BCR-ABL with an IC50 of 5.2 μM, 17-AAG has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively, by inducing the degradation of both wild-type BCR-ABL protein and mutants. [3]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A549 NVn5enl3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml6xTWM2OD1yLkCwNFMxOyEQvF2= MWHTRW5ITVJ?
IST-MEL1 NIPXToRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3hVGtKSzVyPUCuNFAxPDB5IN88US=> M4q4Z3NCVkeHUh?=
NCI-SNU-1 M{HSVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPWTWM2OD1yLkCwNlA4KM7:TR?= M2\XSnNCVkeHUh?=
FADU MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMECyNFkh|ryP MnXFV2FPT0WU
C32 M1;TZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnufG5KSzVyPUCuNFA{ODRizszN MnHvV2FPT0WU
D-566MG Mn;6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkK3TWM2OD1yLkCwN|kh|ryP NH\rfHdUSU6JRWK=
LXF-289 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYi2V495UUN3ME2wMlAxPDF7IN88US=> NIrnfFlUSU6JRWK=
HGC-27 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHqw[Y9KSzVyPUCuNFA2OSEQvF2= M1LwSHNCVkeHUh?=
RPMI-7951 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7SeWVHUUN3ME2wMlAxPzF5IN88US=> NYjzPZdRW0GQR1XS
HSC-3 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUOwU|A4UUN3ME2wMlAxQTJ7IN88US=> MWPTRW5ITVJ?
MIA-PaCa-2 NWjBXHR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnS3TWM2OD1yLkCxNFA6KM7:TR?= NGOwcJlUSU6JRWK=
KS-1 NFnzbHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHmTWM2OD1yLkCxN|U2KM7:TR?= MkXOV2FPT0WU
CAL-51 MkP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwMEG0NFUh|ryP M3:wOHNCVkeHUh?=
MDA-MB-361 MorkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfFTWM2OD1yLkCxOFk2KM7:TR?= MmTHV2FPT0WU
TI-73 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHWxXmdKSzVyPUCuNFE4QTZizszN NWHHVJlbW0GQR1XS
AGS NIKyS3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwMEG5N|gh|ryP NETU[45USU6JRWK=
NCI-H460 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwMEG5O|Qh|ryP M1j4eHNCVkeHUh?=
A204 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlj0TWM2OD1yLkCyNlQ6KM7:TR?= NWnWXYo5W0GQR1XS
CHL-1 NEnFTGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX61V2p7UUN3ME2wMlAzOjVzIN88US=> NGLsdGRUSU6JRWK=
DU-4475 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\WeIhMUUN3ME2wMlAzOjZzIN88US=> MUjTRW5ITVJ?
CGTH-W-1 NV[ydlVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMEKzOFkh|ryP MofRV2FPT0WU
HCC2218 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTBwMEK0PVQh|ryP MkH1V2FPT0WU
A2780 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1z3NGlEPTB;MD6wNlU{OSEQvF2= M1\ib3NCVkeHUh?=
NCI-H720 M375SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMEK1OFYh|ryP NY\o[WU2W0GQR1XS
NCI-N87 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHxTWM2OD1yLkCyOVk{KM7:TR?= MleyV2FPT0WU
CHP-212 MonCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMEK2Nlgh|ryP M4W1VXNCVkeHUh?=
NCI-H23 NHftSlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzQUIVlUUN3ME2wMlAzPjZ3IN88US=> NYizdmI3W0GQR1XS
D-263MG NHL3U5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkntTWM2OD1yLkCyO|g3KM7:TR?= MUPTRW5ITVJ?
ME-180 Ml3YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfpSpFiUUN3ME2wMlAzQDlzIN88US=> NYrNWGlMW0GQR1XS
SW982 MmPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nKSWlEPTB;MD6wNlk6QSEQvF2= M4fjTnNCVkeHUh?=
OE19 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMEOwO|ch|ryP Mn;zV2FPT0WU
SK-LU-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnKzTWM2OD1yLkCzNFgzKM7:TR?= M3nubXNCVkeHUh?=
H4 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMEOwPUDPxE1? MkHyV2FPT0WU
HT-144 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfkbmQxUUN3ME2wMlA{ODl|IN88US=> M2j5RXNCVkeHUh?=
SK-UT-1 M2nCdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfwWIw3UUN3ME2wMlA{OTd6IN88US=> NEjkNHpUSU6JRWK=
D-336MG MmXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\CTWM2OD1yLkCzN|A6KM7:TR?= MnLPV2FPT0WU
MDA-MB-175-VII MlXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\iTWM2OD1yLkCzN|U1KM7:TR?= MV\TRW5ITVJ?
GAMG M1zKRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nzW2lEPTB;MD6wN|Q{PSEQvF2= M{nMZXNCVkeHUh?=
CP50-MEL-B NWjBblhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjHTWM2OD1yLkCzOFUh|ryP NX3MWnl7W0GQR1XS
OVCAR-5 M3zWPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMEO0PEDPxE1? MWPTRW5ITVJ?
SK-MES-1 MojMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLqXHRKSzVyPUCuNFM3ODZizszN MmCzV2FPT0WU
VM-CUB-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TnS2lEPTB;MD6wN|Y2PyEQvF2= NGP6eplUSU6JRWK=
WM-115 NXX0c4hqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwMEO3OlIh|ryP MlPlV2FPT0WU
DSH1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\we|ZUUUN3ME2wMlA{QDB5IN88US=> NIrzSJZUSU6JRWK=
Becker MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\2TWM2OD1yLkCzPFg2KM7:TR?= MYrTRW5ITVJ?
SW962 M3ra[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwMEO5OFUh|ryP MonXV2FPT0WU
TYK-nu M3K3WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTNc2c5UUN3ME2wMlA{QTh3IN88US=> MXnTRW5ITVJ?
HO-1-N-1 NEfj[3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HLbmlEPTB;MD6wOFAzOSEQvF2= M4HLW3NCVkeHUh?=
T98G NUHWUG45T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLCTWM2OD1yLkC0NVA{KM7:TR?= M1rKdnNCVkeHUh?=
ACN MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMESxOlIh|ryP MX\TRW5ITVJ?
SW780 MoDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVH1XWZvUUN3ME2wMlA1OjB|IN88US=> NHztV3RUSU6JRWK=
Detroit562 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV[1XGdQUUN3ME2wMlA1OjN7IN88US=> M3;sbXNCVkeHUh?=
BB49-HNC NXnRVIlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nqbWlEPTB;MD6wOFI1OyEQvF2= MorBV2FPT0WU
HN M1LNd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYf2[ldnUUN3ME2wMlA1Ojd{IN88US=> M1ruVnNCVkeHUh?=
H9 M{fxU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvSSpFKSzVyPUCuNFQ{PzFizszN MVrTRW5ITVJ?
VA-ES-BJ M{i4NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fw[GlEPTB;MD6wOFQ1PyEQvF2= NXzS[Y5zW0GQR1XS
MEL-JUSO NHrjXYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlG4TWM2OD1yLkC0OFc2KM7:TR?= MUPTRW5ITVJ?
BT-474 M4TkR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkniTWM2OD1yLkC0OUDPxE1? NWDHN|NCW0GQR1XS
CaR-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwMES1OFkh|ryP NXzoSop7W0GQR1XS
PSN1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzpVnJXUUN3ME2wMlA1PjB|IN88US=> NHnqbWlUSU6JRWK=
KYSE-510 M3HUXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7xTWM2OD1yLkC0OlQ6KM7:TR?= NWTIRW9iW0GQR1XS
KP-4 NU\nfYw3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMES3OVMh|ryP M{LSRnNCVkeHUh?=
KYSE-410 NX\aN2RHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInkOldKSzVyPUCuNFQ4PzJizszN NF\IZZNUSU6JRWK=
G-402 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUG3dWk{UUN3ME2wMlA1Pzh7IN88US=> MXPTRW5ITVJ?
DOK MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jje2lEPTB;MD6wOFkxOiEQvF2= NVXOSoZGW0GQR1XS
COR-L88 NYXBZ5RVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvMdYpxUUN3ME2wMlA1QTF{IN88US=> MnnnV2FPT0WU
SKG-IIIa NF24cmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMES5PFYh|ryP NETQbYJUSU6JRWK=
AN3-CA NHnIfnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzjTWM2OD1yLkC1JO69VQ>? NWnxPZhEW0GQR1XS
SW48 MkCzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTBwMEWwN|kh|ryP MnXQV2FPT0WU
YKG-1 M3m3WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMEWwO|Eh|ryP MlHDV2FPT0WU
KYSE-150 MnLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnziTWM2OD1yLkC1NlM2KM7:TR?= M37KPXNCVkeHUh?=
HuO-3N1 NHPDPGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnvVpFKSzVyPUCuNFUzOzdizszN MomxV2FPT0WU
LB1047-RCC Mn;XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYKyOGdLUUN3ME2wMlA2Ojl4IN88US=> M2D0THNCVkeHUh?=
NCI-H2030 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTmc4ZKSzVyPUCuNFU1OTRizszN M3vuWHNCVkeHUh?=
YH-13 M1r5fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PG[GlEPTB;MD6wOVczOiEQvF2= M3za[HNCVkeHUh?=
5637 NF64cG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MneyTWM2OD1yLkC1O|Qh|ryP MVrTRW5ITVJ?
LOXIMVI NF20T2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwMEW4O|Ih|ryP NYLhZVFGW0GQR1XS
GT3TKB MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIL4PJFKSzVyPUCuNFU6PDJizszN NI\WeFdUSU6JRWK=
TCCSUP M{DNe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjoW21sUUN3ME2wMlA2QTZ2IN88US=> NXXP[Gw2W0GQR1XS
EPLC-272H MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrhTlZ4UUN3ME2wMlA3OjB3IN88US=> NWLxRVVkW0GQR1XS
LU-99A MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\uVnVKSzVyPUCuNFYzOzdizszN MUTTRW5ITVJ?
NCI-H1755 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;DdXo{UUN3ME2wMlA3OzRzIN88US=> NET0TmxUSU6JRWK=
KM12 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\hbIZKSzVyPUCuNFY{PDhizszN M{[4UnNCVkeHUh?=
SF295 NW[5fmhbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwME[0OVIh|ryP NIfIR4FUSU6JRWK=
MZ2-MEL M1;KNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwME[1OVMh|ryP NFr0epRUSU6JRWK=
HEC-1 NXjlcJRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPCcWFKSzVyPUCuNFY2QDhizszN NXrUfmI2W0GQR1XS
SW684 MlL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\kbIhKSzVyPUCuNFY2QTFizszN MoToV2FPT0WU
SF539 NGmydpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfIT5pyUUN3ME2wMlA3PjhzIN88US=> MU\TRW5ITVJ?
GMS-10 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwME[2PVkh|ryP NYnNeGs2W0GQR1XS
MV-4-11 NV3WWJY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHFTWM2OD1yLkC2PFA{KM7:TR?= NHvs[mpUSU6JRWK=
HT-29 M1OwSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTlTWM2OD1yLkC2PVE6KM7:TR?= NIjORoxUSU6JRWK=
23132-87 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTBwME[5OUDPxE1? NULmd5poW0GQR1XS
SW620 M1HQcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwMEewNlYh|ryP NVjubGZSW0GQR1XS
HCC1806 M1XuWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7yUolKSzVyPUCuNFcyOzFizszN NHn2[VJUSU6JRWK=
Hs-578-T NFLNPVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGD3TldKSzVyPUCuNFczODhizszN MVLTRW5ITVJ?
A2058 NW\SfXVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HONWlEPTB;MD6wO|IzQCEQvF2= MnfiV2FPT0WU
MEL-HO NGjrW2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMEeyOVUh|ryP NWH0Z2dIW0GQR1XS
HCC2998 Mo\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPZ[Y9KSzVyPUCuNFc{PDdizszN MX;TRW5ITVJ?
HuO9 MnLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTDTWM2OD1yLkC3OVg6KM7:TR?= NXX2epZ{W0GQR1XS
CAL-39 NITHPYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfpTJk3UUN3ME2wMlA4PzZ4IN88US=> NXHJRpN2W0GQR1XS
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Calu-3 MnzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzIWFhkUUN3ME20Mlc5PTR6IN88US=> MYHTRW5ITVJ?
HT55 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLQXFJKSzVyPUSuPFQ2PDVizszN NV7ocHl1W0GQR1XS
SK-N-FI NVK5b49qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\DXXBGUUN3ME20Mlg2ODB7IN88US=> M1j2fXNCVkeHUh?=
ES1 MlrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rXdmlEPTB;ND64OlA2PyEQvF2= MmHXV2FPT0WU
SF126 M2rEXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;FTWM2OD12LkmzNVg1KM7:TR?= NIG0VXNUSU6JRWK=
ES5 M16xcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULZcoU1UUN3ME21MlEzPDJ5IN88US=> NUPRTHY6W0GQR1XS
LoVo NInTdY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TVXGlEPTB;NT6xOVg4OSEQvF2= NHyzTmhUSU6JRWK=
SNU-387 NGjk[3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\UVGlEPTB;NT6zNlM{QSEQvF2= M1LUXnNCVkeHUh?=
C8166 M33E[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XhZ2lEPTB;NT6zOlM{QSEQvF2= MX;TRW5ITVJ?
LS-1034 NX;XWWZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XyZmlEPTB;NT60NlMxPyEQvF2= MXHTRW5ITVJ?
GR-ST NW\zTo57T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnYc2FtUUN3ME21MlUzOjBzIN88US=> MlPSV2FPT0WU
NCI-H1092 NIfK[I5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHad3lqUUN3ME21MlczQDR|IN88US=> NX;LT|FOW0GQR1XS
647-V M2DhdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXvTopxUUN3ME21Mlc1PzB4IN88US=> M{nLRnNCVkeHUh?=
EW-13 NYftc3JFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\XTWM2OD13Lke2OlI4KM7:TR?= NHPvcmVUSU6JRWK=
KGN MkHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XYfGlEPTB;Nj6wPVkzOSEQvF2= MlzxV2FPT0WU
D-423MG MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoK4TWM2OD14LkSwNlg1KM7:TR?= M3LOd3NCVkeHUh?=
ECC10 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTdwMUCxNFEh|ryP MmHyV2FPT0WU
TE-5 NF:w[FVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXIRXpxUUN3ME23MlQyOjl6IN88US=> MUnTRW5ITVJ?
P12-ICHIKAWA MoryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\iNGlEPTB;Nz60OVUzOyEQvF2= MX\TRW5ITVJ?
NCI-H82 MnXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDrSnpQUUN3ME23MlQ2PzBzIN88US=> MW\TRW5ITVJ?
NCI-H1993 NX7FT29jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljvTWM2OD15LkizNFY{KM7:TR?= NHvxOYNUSU6JRWK=
RH-1 NYjtc|h3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTdwOEWyOFQh|ryP MYXTRW5ITVJ?
SW948 M{i5V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XyXmlEPTB;Nz65OlA1QSEQvF2= MlPGV2FPT0WU
CAL-33 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTdwOUm5N|gh|ryP NV:zV4hFW0GQR1XS
U-266 M3HQfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PMVWlEPTB;OD6xOVc4PyEQvF2= M3fKcHNCVkeHUh?=
CAL-72 Mo\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7tOYloUUN3ME24MlIxOzJizszN MVnTRW5ITVJ?
SNU-423 NHznco5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTrOVl7UUN3ME25MlM3PjZ4IN88US=> M2TmTHNCVkeHUh?=
KG-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV2w[oxKUUN3ME25MlU5PDV4IN88US=> M2L6SXNCVkeHUh?=
HCC1395 Mk\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVmwV2xsUUN3ME25MlkzOzV{IN88US=> NWLh[WFQW0GQR1XS
BE-13 NIS4VXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDPTWM2OD1zMD64PFkzKM7:TR?= MonwV2FPT0WU
MKN7 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXn2S2dIUUN3ME2xNE46PzZ3IN88US=> MVzTRW5ITVJ?
697 NYrsSpZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVKzXXU1UUN3ME2xNU4yPDd{IN88US=> NHfFVIZUSU6JRWK=
LU-135 NU\6SJQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\ONIRrUUN3ME2xNU4zOzB5IN88US=> NYHje5o4W0GQR1XS
ES7 MnjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmT3TWM2OD1zMT6zN|E{KM7:TR?= NGjqPZlUSU6JRWK=
SK-HEP-1 M1y2PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\1eWlEPTB;MUGuO|Y1PiEQvF2= NYnoSINiW0GQR1XS
BEN NVLNZYNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml:5TWM2OD1zMT64OVEh|ryP MYTTRW5ITVJ?
NCI-H1770 NUXkbG1XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTF{LkGyOkDPxE1? MXzTRW5ITVJ?
SW13 M1\mcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7ZR3VKUUN3ME2xNk4yPTRzIN88US=> Mly0V2FPT0WU
MZ1-PC NFv6fGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17GR2lEPTB;MUKuOVQ2OiEQvF2= MnPFV2FPT0WU
Mo-T Mlr1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILZWW1KSzVyPUGyMlc1OjFizszN M3X4c3NCVkeHUh?=
HLE NX7hUmluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rUeWlEPTB;MUKuPFIyPSEQvF2= M1LXPXNCVkeHUh?=
RCC10RGB MnXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTF|Lk[3NUDPxE1? MXPTRW5ITVJ?
COLO-320-HSR MnnuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rmemlEPTB;MUOuO|M5OSEQvF2= MnTlV2FPT0WU
BHT-101 MljhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDVNo1tUUN3ME2xN{45OzR3IN88US=> NYLhUJg1W0GQR1XS
OCUB-M MnnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTF2LkG2NFIh|ryP MmT6V2FPT0WU
MEG-01 NGnmRYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTF2LkO3NFgh|ryP M3XGUnNCVkeHUh?=
RS4-11 Mn7IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TOemlEPTB;MUSuO|QzKM7:TR?= MnXPV2FPT0WU
MN-60 M2L1OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13zbWlEPTB;MUSuO|g6PCEQvF2= NVLqdHY3W0GQR1XS
NCI-H1304 MmnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTF3LkC0NlUh|ryP NILGXXhUSU6JRWK=
Ramos-2G6-4C10 MkOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPZfG9OUUN3ME2xOU4xPThzIN88US=> NFvSboJUSU6JRWK=
NCI-H2342 M3jrZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPwTWM2OD1zNT6yNFQ1KM7:TR?= MXTTRW5ITVJ?
LAN-6 NFHKWm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\6dlBKSzVyPUG1MlQ1OTRizszN NWPzWVlFW0GQR1XS
JVM-2 NWHLNXl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDBTWM2OD1zNT61O|Q5KM7:TR?= MYDTRW5ITVJ?
P30-OHK MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nsXWlEPTB;MU[uNFYyPCEQvF2= MXLTRW5ITVJ?
C-33-A MkH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHDfppKSzVyPUG2MlYzOTRizszN NYq0c5g4W0GQR1XS
RPMI-8866 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTF4Lki0PVYh|ryP NHHPNppUSU6JRWK=
NCI-H630 Mn;JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPrTWM2OD1zNj64OVM4KM7:TR?= NInaZYtUSU6JRWK=
KYSE-140 M4nRfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;MTGlEPTB;MUeuNlAzQCEQvF2= NVW5W3lWW0GQR1XS
T84 Ml;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{n1fWlEPTB;MUiuPFY6PSEQvF2= M2\kWnNCVkeHUh?=
KU-19-19 MmXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofKTWM2OD1zOD65OlA5KM7:TR?= NHnQZ5hUSU6JRWK=
BALL-1 NEPxU21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4e3[mlEPTB;MUmuN|M6QSEQvF2= M{fmfnNCVkeHUh?=
Calu-6 M4Lpfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYe0[ZkzUUN3ME2xPU41QTJizszN NYH4WlNQW0GQR1XS
EGI-1 NYK1bmVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XEOWlEPTB;MUmuOVk5KM7:TR?= NUHCc3FiW0GQR1XS
MFH-ino MmLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\hUXdjUUN3ME2xPU44PDV2IN88US=> NWf3WZNqW0GQR1XS
GB-1 NVTtNIF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTJyLkO1N|Uh|ryP NYH1XVZKW0GQR1XS
NCI-H1693 NXTMVYJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTJyLk[1NFUh|ryP MV\TRW5ITVJ?
SW1116 M2PPN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjFN4pKSzVyPUKwMlk{PjJizszN NIP4VG9USU6JRWK=
H-EMC-SS MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTJ{LkC0OUDPxE1? NW\Vfo9KW0GQR1XS
D-502MG Ml3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXNcFhKSzVyPUKyMlgzPjFizszN MXfTRW5ITVJ?
IA-LM NUnhdY9GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzQPJpKSzVyPUKzMlI1QTNizszN M3;6W3NCVkeHUh?=
SW1463 M{DXVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjtO4FKSzVyPUKzMlc6KM7:TR?= MYrTRW5ITVJ?
JAR MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDaTWM2OD1{ND6zNlk{KM7:TR?= NYew[VNXW0GQR1XS
HT M2j5Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nOZmlEPTB;MkSuOFc2OyEQvF2= M1;NXnNCVkeHUh?=
LCLC-103H NFXnOHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vWfGlEPTB;MkSuPFQ1QSEQvF2= M3fjc3NCVkeHUh?=
SNU-449 MkHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3T4S2lEPTB;MkSuPFc1OSEQvF2= NVr1NoJbW0GQR1XS
KE-37 Mo[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTJ3LkC5Nlgh|ryP MmnJV2FPT0WU
NCI-H1623 Mn22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTJ5LkGzNFMh|ryP NIfVdZNUSU6JRWK=
MOLT-13 NXnseVVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PCR2lEPTB;MkeuN|UyPiEQvF2= NX3kU3dkW0GQR1XS
COLO-741 NIXxNm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHoWnROUUN3ME2zNU4{OzN|IN88US=> MXvTRW5ITVJ?
NB6 NV3wVnhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;DXGlEPTB;M{KuNlg4PiEQvF2= NXLQNG9lW0GQR1XS
MOLT-16 NVHid21JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHtTWM2OD1|Mz6wNFU2KM7:TR?= M4O0d3NCVkeHUh?=
IST-MES1 NITTeWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDoSIVFUUN3ME2zOE4xPTRzIN88US=> NHvjZpBUSU6JRWK=
A4-Fuk MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTN3LkC2OkDPxE1? MkX2V2FPT0WU
CAL-85-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjJeIlKSzVyPUO1MlI5OTdizszN MVTTRW5ITVJ?
CCRF-CEM NVjJ[|BGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\qTWM2OD1|Nz6xOVM3KM7:TR?= MnK5V2FPT0WU
HAL-01 M17ZOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfHTWM2OD1|OD60PFg6KM7:TR?= NXPZVFBQW0GQR1XS
HEL NEDkV21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTR|LkO0NFkh|ryP NUHtUYVtW0GQR1XS
EW-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTR|LkS3Olgh|ryP M37HUXNCVkeHUh?=
MDA-MB-231 NXfvS|ZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{D5N2lEPTB;NEWuNVE6QSEQvF2= NU\xSJdPW0GQR1XS
ABC-1 M4\jSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jPT2lEPTB;NE[uPFU{QCEQvF2= M1PqPHNCVkeHUh?=
NCI-H446 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\PXGlEPTB;NEiuOVA2QCEQvF2= M2izdHNCVkeHUh?=
MHH-PREB-1 MnvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHxNoVXUUN3ME20PU43ODB5IN88US=> M2CwRXNCVkeHUh?=
DOHH-2 M4nXcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTR7Lk[2OVYh|ryP NHfuVlFUSU6JRWK=
GCT MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLLTWM2OD12OT62PVc3KM7:TR?= MXXTRW5ITVJ?

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

体内試験 17-AAG displays significantly higher binding affinity for Hsp90 from 3T3-src, B16 or CT26 xenografts in nude mice with IC50 values of 8-35 nM as compared with that from the normal tissues with IC50 values of 200-600 nM. [1] Administration of 17-AAG (~50 mg/kg) causes significant decline in AR, HER2, HER3, and Akt expression in a dose-dependent manner with >50% decline at dose of 50 mg/kg, resulting in the dose-dependent inhibition of androgen-dependent (CWR22) and -independent (CWR22R and CWRSA6) prostate cancer xenografts growth by 67%, 80% and 68% at dose of 50 mg/kg, respectively. [2]

お薦めの試験操作(参考用のみ)

キナーゼ試験:[1]
+ 展開

Hsp90 binding assays:

Purified native Hsp90 protein or cell lysates from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells in lysis buffer (20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl2, 100 mM KCl) are incubated with various concentrations of 17-AAG for 30 minutes at 4 °C, and then incubated with biotin-GM linked to BioMag streptavidin magnetic beads for 1 hour at 4 °C. Tubes are placed on a magnetic rack, and the unbound supernatant removed. The magnetic beads are washed three times in lysis buffer and heated for 5 minutes at 95 °C in SDS–PAGE sample buffer. Samples are analysed on SDS protein gels, and western blots done using indicated antibodies. Bands in the western blots are quantified using the Bio-rad Fluor-S MultiImager, and the percentage inhibition of binding of Hsp90 to the biotin-GM is calculated. The IC50 reported is the concentration of 17-AAG needed to cause half-maximal inhibition of binding.
細胞試験: [1]
+ 展開
  • 細胞株: BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, and PBMC cells
  • 濃度: Dissolved in DMSO, final concentrations ~10 μM
  • 反応時間: 5 days
  • 実験の流れ: Cells are seeded in 96-well plates at 2,000 cells per well in a final culture volume of 100 μL for 24 hours before the addition of increasing concentrations of 17-AAG that is incubated for 5 days. Viable cell number is determined using the Celltiter 96 AQueous Nonradioactive Cell Proliferation Assay. The value of the background absorbance at 490 nm (A490) of wells not containing cells is subtracted. Percentage of viable cells = (A490 of 17-AAG treated sample/A490 untreated cells) × 100. The IC50 is defined as the concentration that gave rise to 50% viable cell number.
    (参考用のみ)
動物試験:[2]
+ 展開
  • 動物モデル: Male nu/nu athymic mice inoculated s.c. with androgen-dependent CWR22 xenograft, and female nu/nu athymic mice inoculated s.c. with androgen-independent xenografts CWR22R and CWRSA6
  • 製剤: Dissolved in DMSO, and diluted in egg phospholipids (EPL) vehicle
  • 投薬量: ~50 mg/kg
  • 投与方法: Injection i.p.
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 100 mg/mL (170.73 mM)
Ethanol 5 mg/mL (8.53 mM)
Water Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
5%DMSO+corn oil
混合させたのち直ちに使用することを推奨します。
10mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 585.69
化学式

C31H43N3O8

CAS No. 75747-14-7
保管
in solvent
別名 CP127374,NSC-330507, KOS 953

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00577889 Completed Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage IV Pancreatic Cancer National Cancer Institute (NCI) March 2008 Phase 2
NCT00546780 Completed Multiple Myeloma Bristol-Myers Squibb February 2008 Phase 3
NCT00093496 Completed Primary Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer|Stage III Ovarian Epithelial Cancer|Stage IV Ovarian Epithelial Cancer National Cancer Institute (NCI) October 2007 Phase 2
NCT00514371 Completed Multiple Myeloma Bristol-Myers Squibb August 2007 Phase 2|Phase 3
NCT00779428 Completed Advanced Malignancies Bristol-Myers Squibb July 2006 Phase 2
NCT00354185 Terminated Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Post-transplant Lymphoproliferative Disorder|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Stage III Adult Burkitt Lymphoma|Stage III Adult Diffuse Large Cell Lymphoma|Stage III Adult Diffuse Mixed Cell Lymphoma|Stage III Adult Diffuse Small Cleaved Cell Lymphoma|Stage III Adult Hodgkin Lymphoma|Stage III Adult Immunoblastic Large Cell Lymphoma|Stage III Adult Lymphoblastic Lymphoma|Stage III Adult T-cell Leukemia/Lymphoma|Stage III Cutaneous T-cell Non-Hodgkin Lymphoma|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage III Marginal Zone Lymphoma|Stage III Mycosis Fungoides/Sezary Syndrome|Stage III Small Lymphocytic Lymphoma|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Mixed Cell Lymphoma|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Stage IV Adult Hodgkin Lymphoma|Stage IV Adult Immunoblastic Large Cell Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Adult T-cell Leukemia/Lymphoma|Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Mycosis Fungoides/Sezary Syndrome|Stage IV Small Lymphocytic Lymphoma|Unspecified Adult Solid Tumor Protocol Specific|Waldenström Macroglobulinemia National Cancer Institute (NCI) May 2006 Phase 1

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よくある質問(FAQ)

  • 質問1:

    What kind of subtypes does this compound inhibit? HSP90α or HSP90β ?

  • 回答:

    17-AAG can inhibit both HSP90α and HSP90β, but it is unclear how much are they affected respectively. You should note that Hsp90 derived from tumor cells has a 100-fold higher binding affinity for 17-AAG than that from normal cells according to this paper. http://www.nature.com.ezp-prod1.hul.harvard.edu/nature/journal/v425/n6956/full/nature01913.html

HSP (e.g. HSP90)シグナル伝達経路

HSP (e.g. HSP90) Inhibitors with Unique Features

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