Luminespib (AUY-922, NVP-AUY922)

製品コードS1069 別名:VER-52296

Luminespib (AUY-922, NVP-AUY922)化学構造

分子量(MW):465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

サイズ 価格(税別)  
JPY 53120.00
JPY 26560.00
JPY 44820.00
JPY 78020.00

カスタマーフィードバック(3)

  • U2OS_exo cells were incubated with AUY922 for 20 h at the indicated concentrations before stimulation with TNFα (30 ng/mL) for 30 min and immunostaining to detect NF-κB (p65). DMSO 1%, cells stimulated by TNFα in the absence of AUY922. Representative pictures used to quantify nuclear and cytoplasmic localization of NF-κB.

    Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

    J Biol Chem 2013 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

  • Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922  (ie, induction of HSP72 and depletion of client proteins such as ERBB2, CRAF and CDK4) in BT474 breast cancer cell line. GAPDH was used as loading control.

     

     

    2011 Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

製品安全説明書

HSP (e.g. HSP90)阻害剤の選択性比較

生物活性

製品説明 Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
ターゲット
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
体外試験

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CMK NH7qXplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHYfYd[UUN3ME2wMlAxODF{NTFOwG0> MoL3V2FPT0WU
MV-4-11 NITYRo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XUXmlEPTB;MD6wNFA2PThizszN MkjnV2FPT0WU
NALM-6 NWqyRZRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPqbY9sUUN3ME2wMlAxODh2MjFOwG0> M3THbXNCVkeHUh?=
HOS NYXGO|luT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXxTWM2OD1yLkCwNVM5KM7:TR?= MWXTRW5ITVJ?
HT-144 NV[2cHFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XTbmlEPTB;MD6wNFE2PSEQvF2= M{ey[3NCVkeHUh?=
SW1710 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\5UGlEPTB;MD6wNFE5PiEQvF2= NHrxUYpUSU6JRWK=
TE-8 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLpXIhKSzVyPUCuNFAzOzdizszN MoHvV2FPT0WU
ES1 NEXQfWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwMECyOlYh|ryP NULveolYW0GQR1XS
CCF-STTG1 M4OzXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M323VGlEPTB;MD6wNFI6PyEQvF2= MV\TRW5ITVJ?
PSN1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjJUJg{UUN3ME2wMlAxOzF6IN88US=> MofDV2FPT0WU
CAL-51 NEDPOYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwMECzNlUh|ryP Mmm0V2FPT0WU
MCF7 Ml3aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrKTWM2OD1yLkCwN|M2KM7:TR?= M17GRnNCVkeHUh?=
SK-HEP-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTjTpZKSzVyPUCuNFA{OzZizszN M{PqU3NCVkeHUh?=
LCLC-103H MlfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\QXmlEPTB;MD6wNFQ{KM7:TR?= M4Doe3NCVkeHUh?=
HMV-II M4jjdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTBwMEC0OFkh|ryP MVrTRW5ITVJ?
MES-SA NIG2WolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3ixS2lEPTB;MD6wNFQ2OiEQvF2= M3TyXHNCVkeHUh?=
SK-LMS-1 MkPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PHZmlEPTB;MD6wNFQ2QCEQvF2= NUHkcFN[W0GQR1XS
639-V NXPOOZBpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHji[WdKSzVyPUCuNFA1QDVizszN NVfvbII2W0GQR1XS
SIG-M5 Mn\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3POHViUUN3ME2wMlAxPDh7IN88US=> M1j6cHNCVkeHUh?=
LOUCY MoTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M136R2lEPTB;MD6wNFUxPSEQvF2= NXzL[4hTW0GQR1XS
HSC-2 NGXKNJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwMEC1NVgh|ryP M1vKTHNCVkeHUh?=
EW-13 NVPqWpFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojKTWM2OD1yLkCwOVE5KM7:TR?= MVnTRW5ITVJ?
RT-112 MoLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1v0NGlEPTB;MD6wNFU{PSEQvF2= NWnTOWY2W0GQR1XS
NKM-1 MoXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{O2UWlEPTB;MD6wNFU1PyEQvF2= MmjyV2FPT0WU
KYSE-180 NGXTUotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPsTWM2OD1yLkCwOVg3KM7:TR?= MUfTRW5ITVJ?
SW1783 NHjsfWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jMTGlEPTB;MD6wNFU6OSEQvF2= NFXnNYZUSU6JRWK=
A431 MmLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M372V2lEPTB;MD6wNFYxPyEQvF2= M1Pw[3NCVkeHUh?=
SK-OV-3 M4X3R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLnTWM2OD1yLkCwOlMh|ryP MYLTRW5ITVJ?
RPMI-7951 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnOe4ZyUUN3ME2wMlAxPjNzIN88US=> M2[xU3NCVkeHUh?=
Capan-2 NXjtW203T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHEOpJKSzVyPUCuNFA3OzhizszN NFniVpVUSU6JRWK=
HSC-3 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3z4NWlEPTB;MD6wNFY1OSEQvF2= M{e2fnNCVkeHUh?=
786-0 M4Czbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjyXItOUUN3ME2wMlAxPjZ|IN88US=> NEfhTlRUSU6JRWK=
Daoy NHLuSHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jxT2lEPTB;MD6wNFY6PSEQvF2= Mm\xV2FPT0WU
KGN MlLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3:5bWlEPTB;MD6wNFcxOyEQvF2= MVfTRW5ITVJ?
EW-16 MlPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HjdWlEPTB;MD6wNFc1QSEQvF2= NWfqSXVLW0GQR1XS
EW-7 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjqUWhKSzVyPUCuNFA4PTRizszN NI\sb4ZUSU6JRWK=
IGROV-1 M1PPdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUe0bFFQUUN3ME2wMlAxQDF2IN88US=> MUHTRW5ITVJ?
8505C NGLyW|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TrS2lEPTB;MD6wNFgzOSEQvF2= NXv4Z4pGW0GQR1XS
RKO Mn:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwMEC4NlYh|ryP M3[1VnNCVkeHUh?=
GDM-1 NXfDb2M6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMEC4OEDPxE1? NVnOSYt[W0GQR1XS
IST-MEL1 M3;LUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPUWYFKSzVyPUCuNFA5PTJizszN MYfTRW5ITVJ?
RPMI-6666 MorGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3ThdmlEPTB;MD6wNFg2OiEQvF2= M3LmcXNCVkeHUh?=
SNG-M NU[3bYpmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMEC4OVYh|ryP Mn3rV2FPT0WU
KS-1 M17BPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXsPGN7UUN3ME2wMlAxQDV7IN88US=> MnjyV2FPT0WU
RXF393 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfLUldkUUN3ME2wMlAxQDZizszN M4[2eXNCVkeHUh?=
CAL-12T NYexO21rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjpcmxKSzVyPUCuNFA6OjJizszN M4HkZ3NCVkeHUh?=
BFTC-905 NGDEcYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwMEC5N|gh|ryP MX\TRW5ITVJ?
SK-MES-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGO2cWpKSzVyPUCuNFA6PDVizszN M1W2e3NCVkeHUh?=
BB30-HNC M3e4SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TiT2lEPTB;MD6wNFk2OiEQvF2= NUHPUG1YW0GQR1XS
AN3-CA NVv5[|NwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYm3d5NGUUN3ME2wMlAyODF5IN88US=> M2HKcHNCVkeHUh?=
EFO-27 MlHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXwTWM2OD1yLkCxNFE4KM7:TR?= MYTTRW5ITVJ?
G-401 M4\rNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rjUmlEPTB;MD6wNVAzPSEQvF2= NGC1[WtUSU6JRWK=
BPH-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX[3RZhCUUN3ME2wMlAyODNizszN NIP6botUSU6JRWK=
NCI-H727 NGS3UGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwMEGwN{DPxE1? MnnxV2FPT0WU
SNU-423 MmO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXj2ZYRlUUN3ME2wMlAyODV|IN88US=> MUnTRW5ITVJ?
KYSE-270 NUTCe2d2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwMEGwOVkh|ryP NULjW4g1W0GQR1XS
AGS NGXZfFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMEGwOlEh|ryP MU\TRW5ITVJ?
NCI-H2228 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLDWphKSzVyPUCuNFExPjRizszN NXLZfHVLW0GQR1XS
SW954 NUmxNlhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYT1NHU4UUN3ME2wMlAyODdzIN88US=> MnHOV2FPT0WU
769-P M{izZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXTTWM2OD1yLkCxNFc{KM7:TR?= M{fNVXNCVkeHUh?=
BB49-HNC NUTZTWFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLzenhKSzVyPUCuNFExPzdizszN MlHmV2FPT0WU
IA-LM NInISoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnyXGpWUUN3ME2wMlAyODh4IN88US=> NWP4U3Y5W0GQR1XS
NB69 MlXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vSXmlEPTB;MD6wNVExOiEQvF2= M1i5NXNCVkeHUh?=
C8166 NEPsN|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInhWoJKSzVyPUCuNFEyOjlizszN Mny5V2FPT0WU
NCI-H1299 MkTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMEGxOVQh|ryP MWfTRW5ITVJ?
YKG-1 MorES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnCTFVKSzVyPUCuNFEyPiEQvF2= MUPTRW5ITVJ?
PANC-03-27 NW[wRXV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojCTWM2OD1yLkCxNVYzKM7:TR?= MVHTRW5ITVJ?
YT M{j0PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\ZTWM2OD1yLkCxNVc6KM7:TR?= MWfTRW5ITVJ?
CAL-85-1 NXjBeIFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\uPZFKSzVyPUCuNFEyQTJizszN NVmx[21wW0GQR1XS
GT3TKB NXvP[2xST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwMEGyNFIh|ryP MnHyV2FPT0WU
BB65-RCC NHnWN5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXQTWM2OD1yLkCxNlA1KM7:TR?= NIP1O3lUSU6JRWK=
ES6 MkPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMEGyOlEh|ryP NIfadpRUSU6JRWK=
MHH-ES-1 M4D0TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjGcJJjUUN3ME2wMlAyOjZ|IN88US=> NX7VXJlvW0GQR1XS
QIMR-WIL NFqxb3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnnb5pKSzVyPUCuNFEzPjlizszN NHrBe5ZUSU6JRWK=
SNU-C2B NXjXWHd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrWXZpKSzVyPUCuNFEzPzJizszN M3mx[3NCVkeHUh?=
OCI-AML2 MnrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwMEGyPFEh|ryP NX;tV|VzW0GQR1XS
DU-145 NEGzbnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TGXWlEPTB;MD6wNVI6KM7:TR?= NWnQcohFW0GQR1XS
SW982 M1vxdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PWdGlEPTB;MD6wNVI6OyEQvF2= NFXkZmtUSU6JRWK=
MFH-ino MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFSyN41KSzVyPUCuNFEzQTNizszN Mn3NV2FPT0WU
A427 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HrUWlEPTB;MD6wNVI6QSEQvF2= MXjTRW5ITVJ?
LCLC-97TM1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HwV2lEPTB;MD6wNVMh|ryP MUXTRW5ITVJ?
AM-38 NVf2RlZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLoSHJlUUN3ME2wMlAyOzB{IN88US=> M3HpNHNCVkeHUh?=
K5 M4ez[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwMEGzNFgh|ryP Mn7rV2FPT0WU
T84 NH\5dZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnLdWFlUUN3ME2wMlAyOzNzIN88US=> M1PEXXNCVkeHUh?=
TE-15 M3TiW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHmeld6UUN3ME2wMlAyOzN4IN88US=> M1jhW3NCVkeHUh?=
NCI-H460 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7mZ4hNUUN3ME2wMlAyOzN4IN88US=> MV3TRW5ITVJ?
NTERA-S-cl-D1 NULwfVNRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPpU3pKSzVyPUCuNFE{OzlizszN M{jxcHNCVkeHUh?=
KYSE-450 NXXaNZVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TLOGlEPTB;MD6wNVM1QSEQvF2= NFPJNY1USU6JRWK=
H4 MnXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXNTWM2OD1yLkCxN|Y3KM7:TR?= M3zpVHNCVkeHUh?=
LC-2-ad NYHYWGZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfqT5pKSzVyPUCuNFE{PyEQvF2= NF;lNWNUSU6JRWK=
GAMG MoO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMEGzO|Eh|ryP NFfTWIpUSU6JRWK=
TK10 MmLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXiyW3RIUUN3ME2wMlAyOzh{IN88US=> MXfTRW5ITVJ?
NCI-H2122 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwMEGzPFQh|ryP NFXqdWVUSU6JRWK=
KM12 NYT0Wm46T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPOT|J[UUN3ME2wMlAyOzl7IN88US=> MmXyV2FPT0WU
CAL-39 MkHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnpWlk6UUN3ME2wMlAyPDJizszN NV3jNFNiW0GQR1XS
RPMI-2650 NXX1N24yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmj5TWM2OD1yLkCxOFMzKM7:TR?= M37hNHNCVkeHUh?=
KYSE-510 M{fqdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnr3TWM2OD1yLkCxOFQzKM7:TR?= Mn[yV2FPT0WU
KALS-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwMEG0OlYh|ryP MnH5V2FPT0WU
NCI-H1648 NXTib3RzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHENIlKSzVyPUCuNFE1QTlizszN M1[yTHNCVkeHUh?=
ES4 NXXk[JAyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVmyfGt2UUN3ME2wMlAyPTB{IN88US=> NXXGUXBmW0GQR1XS
C-33-A Ml62S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLITWM2OD1yLkCxOVA6KM7:TR?= NIf2dHJUSU6JRWK=
MIA-PaCa-2 NHP5OWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWWybWV[UUN3ME2wMlAyPTB7IN88US=> NH3mXGpUSU6JRWK=
Becker NU\ONYVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPuSoM4UUN3ME2wMlAyPTF2IN88US=> MYfTRW5ITVJ?
HOP-62 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFuxd5dKSzVyPUCuNFE2PDJizszN MVvTRW5ITVJ?
TE-1 NFraWFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMEG1PFEh|ryP MVPTRW5ITVJ?
KYSE-410 NXvNUpRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7KTWM2OD1yLkCxOVg3KM7:TR?= M4rHWnNCVkeHUh?=
NOS-1 MmXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjMe5FKSzVyPUCuNFE2QTNizszN MorYV2FPT0WU
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NCI-H1650 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\WcpRKSzVyPUCuNFE3PDZizszN M2[y[nNCVkeHUh?=
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OS-RC-2 M1rvdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXOTG1KSzVyPUCuNFM{QTZizszN NWTOdVk6W0GQR1XS
SF268 MoO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEGyfFBKSzVyPUCuNFM1ODFizszN M4n1d3NCVkeHUh?=
BV-173 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXTWlFKSzVyPUCuNFM1OjZizszN MXrTRW5ITVJ?
DMS-273 M3rQVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfQT|JzUUN3ME2wMlA{PDd7IN88US=> MVrTRW5ITVJ?
22RV1 NE\RVZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTtWVFtUUN3ME2wMlA{PTB5IN88US=> M1rZWnNCVkeHUh?=
ES8 Mn;WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlT5TWM2OD1yLkCzOVM5KM7:TR?= NHrpb4pUSU6JRWK=
KYSE-150 MkPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mny1TWM2OD1yLkCzOlA5KM7:TR?= MVrTRW5ITVJ?
HCC1569 M3Xs[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXJTWM2OD1yLkCzOlA5KM7:TR?= M1O5PHNCVkeHUh?=
NB5 M1;EfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLHUZZKSzVyPUCuNFM3OTNizszN MmC3V2FPT0WU
G-402 NYfUe5JuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjNPI1KSzVyPUCuNFM3OTRizszN NUPXeodkW0GQR1XS
NCI-H1693 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHXUYh{UUN3ME2wMlA{PjF5IN88US=> MYnTRW5ITVJ?
LB2241-RCC MnKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYL0d3ROUUN3ME2wMlA{PjR{IN88US=> NX;jWodIW0GQR1XS
KP-4 MnznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml[2TWM2OD1yLkCzOlY{KM7:TR?= MW\TRW5ITVJ?
ML-2 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDsTnRKSzVyPUCuNFM3PzFizszN NYO2[nV3W0GQR1XS
KU812 NVu3ZZl6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwMEO2PFQh|ryP MlTVV2FPT0WU
LS-411N MlHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrOdVNKSzVyPUCuNFM4OzFizszN MkLSV2FPT0WU
OAW-42 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHtTWM2OD1yLkCzO|Q4KM7:TR?= MmSzV2FPT0WU
HCC38 NYTrOY5PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\5S|BXUUN3ME2wMlA{PzdzIN88US=> NHTnWW1USU6JRWK=
Ca-Ski M2\EW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3HTWM2OD1yLkCzO|g1KM7:TR?= MnTqV2FPT0WU
Calu-3 M2[0fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PzN2lEPTB;MD6wN|c5QSEQvF2= MnvpV2FPT0WU
KYSE-70 M3XaUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PwTmlEPTB;MD6wN|gyOiEQvF2= M3LrRXNCVkeHUh?=
D-392MG M3LBSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NES0dG5KSzVyPUCuNFM5PDJizszN MUTTRW5ITVJ?
OVCAR-4 NGSxSpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHObYVKSzVyPUCuNFM5PThizszN NVS4dGVTW0GQR1XS
Detroit562 MmjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\WTWM2OD1yLkCzPFczKM7:TR?= M3S3ZXNCVkeHUh?=
HEL NVn2[25VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrYeJBFUUN3ME2wMlA{QDlzIN88US=> NELnco9USU6JRWK=
MONO-MAC-6 NIHnfINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwMEO4PVMh|ryP MULTRW5ITVJ?
LoVo NWDFV|ZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV:5WnEyUUN3ME2wMlA{QTN|IN88US=> M4qy[3NCVkeHUh?=
U-2-OS MlW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XMc2lEPTB;MD6wN|k{PSEQvF2= Mn73V2FPT0WU
A172 NX;USYxrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYC2V4JlUUN3ME2wMlA{QTVizszN MoPHV2FPT0WU
OCUB-M M3zwO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4qwW2lEPTB;MD6wN|k3OSEQvF2= NXe2fXlmW0GQR1XS
SW48 MkLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMESwN|Eh|ryP MYHTRW5ITVJ?
HC-1 M2LHe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMESwOlkh|ryP Mo\RV2FPT0WU
KOSC-2 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUn1UmJHUUN3ME2wMlA1OTFizszN MorzV2FPT0WU
HDLM-2 Mlq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4T0XmlEPTB;MD6wOFEyPCEQvF2= NIn0fZNUSU6JRWK=
CTV-1 NUDycYZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\6TWM2OD1yLkC0NVE3KM7:TR?= NWPkRmY4W0GQR1XS
SH-4 NH7qd2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mny1TWM2OD1yLkC0NVQyKM7:TR?= NIP1UmhUSU6JRWK=
SW756 NGfJSGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwMESxOVch|ryP MmDsV2FPT0WU
GCT NGXiUnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzuUnVKSzVyPUCuNFQyPjFizszN NGDYTYNUSU6JRWK=
CHL-1 MnfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTZXJNKSzVyPUCuNFQyPjlizszN MW\TRW5ITVJ?
LAMA-84 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn6xTWM2OD1yLkC0NVcyKM7:TR?= MknSV2FPT0WU
LS-1034 M2LRTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrxTWM2OD1yLkC0NVkyKM7:TR?= MUfTRW5ITVJ?
NCI-H358 NW\m[ohpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrZTWM2OD1yLkC0NlEzKM7:TR?= NE\6U4JUSU6JRWK=
NB13 MlznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7mbGROUUN3ME2wMlA1OjJ5IN88US=> MX3TRW5ITVJ?
TE-9 NVf2dZJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPyTWM2OD1yLkC0NlM4KM7:TR?= M3HQ[3NCVkeHUh?=
OE33 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPPTFJKSzVyPUCuNFQzPDFizszN NXnsVYtiW0GQR1XS
CAL-120 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMESyOFEh|ryP NWDVb2FpW0GQR1XS
DJM-1 NVzod4hxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMESyO|Ih|ryP M1vXS3NCVkeHUh?=
SK-MEL-24 NUHpOotpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjnTWM2OD1yLkC0Nlg{KM7:TR?= NFPsc4FUSU6JRWK=
VA-ES-BJ NXzXS5RWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMESyPVIh|ryP NUjpc2x6W0GQR1XS
MMAC-SF MmrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwMESyPVch|ryP NXfJR5VLW0GQR1XS
MZ7-mel M4HuVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjYVllKSzVyPUCuNFQ{OyEQvF2= MUPTRW5ITVJ?
BxPC-3 NFrKWZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLj[XhDUUN3ME2wMlA1OzRzIN88US=> M{\mdXNCVkeHUh?=
HT-29 NXTi[|V6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjwbJNKSzVyPUCuNFQ{PTdizszN NH[wdVZUSU6JRWK=
SK-MEL-30 NUHtbZJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3Y[Y9KSzVyPUCuNFQ{PjJizszN MmTqV2FPT0WU
CAL-33 NEP3UnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXnSJRKSzVyPUCuNFQ{PzVizszN NU\PeHZyW0GQR1XS
COLO-680N MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvtTWM2OD1yLkC0OFA4KM7:TR?= M4TYNXNCVkeHUh?=
NH-12 NV7RdJVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PaXGlEPTB;MD6wOFQ1KM7:TR?= NILmflhUSU6JRWK=
HCC1937 NF3uR2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwMES0OVYh|ryP MULTRW5ITVJ?
IMR-5 M3W0e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\C[4JKSzVyPUCuNFQ1QSEQvF2= MnfWV2FPT0WU
MC-CAR NEPadVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTKeJVKSzVyPUCuNFQ2PjlizszN Mnf3V2FPT0WU
NCI-H747 NH[z[YlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFW3cG5KSzVyPUCuNFQ2PyEQvF2= M4LaTXNCVkeHUh?=
NCI-H1792 M2Xuemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwMES1PFEh|ryP MVfTRW5ITVJ?
SW13 MmGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\6bWZKSzVyPUCuNFQ2QSEQvF2= Mn\IV2FPT0WU
MLMA NHjRcXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XY[GlEPTB;MD6wOFYxQSEQvF2= MmmxV2FPT0WU
U251 MlTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwMES3OlMh|ryP MWXTRW5ITVJ?
U031 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwMES3O|Eh|ryP NV7vTY5vW0GQR1XS
ME-180 M{L6dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMES3PFIh|ryP NIDWcZVUSU6JRWK=
SK-MEL-3 NULXSpVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;GTWM2OD1yLkC0PFAzKM7:TR?= NG[0RpVUSU6JRWK=
MOLT-4 NHXUOllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwMES4NFMh|ryP M1fPSXNCVkeHUh?=
PF-382 NIK4[HNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwMES4NlYh|ryP MUHTRW5ITVJ?
NUGC-3 NIPrOnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF[wfXBKSzVyPUCuNFQ5OjdizszN MU\TRW5ITVJ?
NCI-H1417 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLlS4l7UUN3ME2wMlA1QDlizszN M2\HcHNCVkeHUh?=
COLO-205 NGmySIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfwcHhKSzVyPUCuNFQ6OTlizszN MnXqV2FPT0WU
TE-441-T NF\YXlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYOzRWdyUUN3ME2wMlA1QTNizszN MXXTRW5ITVJ?
MKN1 NEi1fW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMES5N{DPxE1? NH3rRm1USU6JRWK=
UM-UC-3 MkfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwMES5OUDPxE1? MmPSV2FPT0WU
SF126 MnjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HlUWlEPTB;MD6wOVAyKM7:TR?= NInZOWZUSU6JRWK=
LB1047-RCC NVTVcJRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTBwMEWwN|Eh|ryP NVm4eXczW0GQR1XS
A253 MkPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYL0N3REUUN3ME2wMlA2ODV{IN88US=> M3f5WXNCVkeHUh?=
NCI-H1963 NYnLeJo3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnGbVZjUUN3ME2wMlA2OTd4IN88US=> MV3TRW5ITVJ?
VM-CUB-1 NG\zZmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfMTWhMUUN3ME2wMlA2OzFzIN88US=> M3G0fXNCVkeHUh?=
T-24 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnsTWM2OD1yLkC1N|g1KM7:TR?= Mlv0V2FPT0WU
K-562 M2nKdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjFXHJKSzVyPUCuNFU{QDdizszN M1niNHNCVkeHUh?=
ARH-77 Ml7NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMEWzPVUh|ryP MnXiV2FPT0WU
CA46 NVrMUWRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwMEW0N{DPxE1? NFK3dVZUSU6JRWK=
HCC70 M2TMNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PTOmlEPTB;MD6wOVQ2OiEQvF2= MX7TRW5ITVJ?
ST486 NWW1UJJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TwdGlEPTB;MD6wOVUzPSEQvF2= MnLyV2FPT0WU
COLO-741 NYPzSVJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwMEW1N|Eh|ryP MVjTRW5ITVJ?
SK-PN-DW MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTOd3huUUN3ME2wMlA2PTh6IN88US=> MVjTRW5ITVJ?
BL-41 MmDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjSTWM2OD1yLkC1OVk3KM7:TR?= MYjTRW5ITVJ?
D-263MG NHmyVlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2G2VmlEPTB;MD6wOVY5OyEQvF2= NXzVVJY{W0GQR1XS
KE-37 NV;EOVNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTBwMEW2PFMh|ryP MlHaV2FPT0WU
LU-134-A MmPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfHbYFsUUN3ME2wMlA2PzF3IN88US=> NGniSHlUSU6JRWK=
HCC2157 M17lUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwMEW3N|Mh|ryP M1LCUHNCVkeHUh?=
GAK Mn64S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\D[WlEPTB;MD6wOVc{PCEQvF2= M{nmN3NCVkeHUh?=
IST-SL2 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLtOXJEUUN3ME2wMlA2PzR|IN88US=> MlW1V2FPT0WU
KMOE-2 NXi1[ZNLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTYV2xKSzVyPUCuNFU4PDlizszN M4fLVXNCVkeHUh?=
SW1573 NU\SSmF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\DTWM2OD1yLkC1PFAzKM7:TR?= M1L5RnNCVkeHUh?=
SCC-9 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXXNJpKSzVyPUCuNFU5PyEQvF2= M4f5b3NCVkeHUh?=
MDA-MB-361 Mlf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\1TWM2OD1yLkC1PFczKM7:TR?= M{HHdXNCVkeHUh?=
BHT-101 NHTMSJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwMEW4O|Yh|ryP MlzzV2FPT0WU
NCI-H1770 M3X6fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTBwMEW4O|kh|ryP MWjTRW5ITVJ?
UACC-893 NYfOdHhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjXe5lqUUN3ME2wMlA2QDl4IN88US=> MWjTRW5ITVJ?
NCI-H226 NGHJTldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfJ[5hqUUN3ME2wMlA2QTh6IN88US=> M1HRPXNCVkeHUh?=
HLE NF\5RmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwME[wPFIh|ryP NULsc4hVW0GQR1XS
NCI-H1703 MlrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;5TWM2OD1yLkC2NVc5KM7:TR?= Mn3oV2FPT0WU
KURAMOCHI M4fWOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jWUWlEPTB;MD6wOlE5QSEQvF2= Mk[2V2FPT0WU
RH-1 M{O0PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwME[yN{DPxE1? NF;uc3NUSU6JRWK=
DSH1 M2jIOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzvTWM2OD1yLkC2Nlch|ryP MlzRV2FPT0WU
CAMA-1 NFHydJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mof4TWM2OD1yLkC2N|A{KM7:TR?= NH\zXmxUSU6JRWK=
NCI-H1437 NHrPWWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLaTWM2OD1yLkC2N|I5KM7:TR?= NXy2blB1W0GQR1XS
HuP-T4 NVP4fmxUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknoTWM2OD1yLkC2OVg3KM7:TR?= NFrKO|RUSU6JRWK=
HCT-15 NFTGcWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwME[1PVch|ryP NXP6VZZWW0GQR1XS
NCCIT NWDFeVRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLMSXd1UUN3ME2wMlA3PjB2IN88US=> NHvRdmJUSU6JRWK=
BOKU NWnUdo82T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XOTmlEPTB;MD6wOlY4PCEQvF2= M2ftc3NCVkeHUh?=
FADU NET1OnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnP2TWM2OD1yLkC2O|Q2KM7:TR?= NY\sdHdDW0GQR1XS
SUP-T1 NHe4d3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjrTWM2OD1yLkC2O|Yh|ryP MYTTRW5ITVJ?
L-363 Mlm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwME[5NFEh|ryP NULTO5Y2W0GQR1XS
KNS-81-FD MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfaTWM2OD1yLkC2PVE5KM7:TR?= M2\oUnNCVkeHUh?=
SU-DHL-1 MnjKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTid4JzUUN3ME2wMlA3QTJizszN M3y3PXNCVkeHUh?=
HuH-7 M3nu[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwMEewN|Uh|ryP MWPTRW5ITVJ?
BT-474 Moq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPkR3htUUN3ME2wMlA4ODZzIN88US=> MkPnV2FPT0WU
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NCI-H1581 NETSbXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrUcXdKSzVyPUGuN|U3QDdizszN M2nISnNCVkeHUh?=
NCI-H748 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTFwM{W3N|gh|ryP M1LEfnNCVkeHUh?=
HCC1187 Mmr2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnT3TWM2OD1zLkW1OVIzKM7:TR?= M4HyZnNCVkeHUh?=
EoL-1-cell Mn\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTFwNUi4PFkh|ryP NGLR[2NUSU6JRWK=
HuO-3N1 M1rCOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfHTWM2OD1zLkizOFEzKM7:TR?= M1fkXXNCVkeHUh?=
NCI-H1793 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFH2[IZKSzVyPUGuPFc2QTNizszN MkfNV2FPT0WU
Caov-3 MnThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nGbWlEPTB;Mj6wNFYzPSEQvF2= M2nNdnNCVkeHUh?=
JAR NEj0bHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\IUJgyUUN3ME2yMlA4QTJizszN MoqzV2FPT0WU
SK-MEL-28 M3Ty[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rCXmlEPTB;Mj6xPFA6QCEQvF2= NHTYV5RUSU6JRWK=
EM-2 NILhXnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkX4TWM2OD1{LkKwNlk{KM7:TR?= MX;TRW5ITVJ?
Mewo MlPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH6xNlFKSzVyPUKuNlIzPjVizszN Mn;qV2FPT0WU
NCI-H720 NHf1c|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkm5TWM2OD1{LkK2OVg2KM7:TR?= MljVV2FPT0WU
CAL-54 NUfmPGs6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTJwMk[3PVUh|ryP MX7TRW5ITVJ?
MC116 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;FNXQxUUN3ME2yMlM3Ozl5IN88US=> MkTSV2FPT0WU
DG-75 NF3PR2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXkU45zUUN3ME2yMlQ5PTd4IN88US=> M3e2[nNCVkeHUh?=
HCC1143 M1rjOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XzdGlEPTB;Mj61NFY2QCEQvF2= NHToSZJUSU6JRWK=
FTC-133 MlO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTJwNUO2PFkh|ryP NYrEdnU3W0GQR1XS
AsPC-1 Mn;BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrMXZNKSzVyPUKuOVM6OjlizszN NELBUWJUSU6JRWK=
NCI-H889 M4LMOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Pmd2lEPTB;Mj61OlcxPiEQvF2= MkPlV2FPT0WU
HT55 M4C0Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjLTYF5UUN3ME2yMlYzODF7IN88US=> M4PmXHNCVkeHUh?=
UMC-11 NIrFSo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGT4SGJKSzVyPUKuO|g4OTVizszN M3fyT3NCVkeHUh?=
P12-ICHIKAWA NGXYN5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHsWYNUUUN3ME2yMlgzODR4IN88US=> NXnzUIREW0GQR1XS
HCC1395 M3:zRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV72VXRsUUN3ME2yMlk5PjB{IN88US=> MUHTRW5ITVJ?
D-283MED MnvSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfTTWM2OD1|LkG4PVM4KM7:TR?= MWXTRW5ITVJ?
COLO-800 M{mwfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTNwM{O4PVch|ryP NIC5N4xUSU6JRWK=
MFM-223 NED6RZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHUWlZGUUN3ME2zMlM3ODl5IN88US=> Mnu2V2FPT0WU
TE-5 M4m3cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHYRZpKSzVyPUSuOVYyPDdizszN M2PBeXNCVkeHUh?=
NCI-H209 MnfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfyd5RKSzVyPUSuO|g2PzJizszN NUTmUFIxW0GQR1XS
SiHa M{W1emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHm4NWZKSzVyPUSuPVUzODNizszN M1O3Z3NCVkeHUh?=
NCI-H1395 NF3DRXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2f2N2lEPTB;NT6xNFY{OyEQvF2= NVLrUpJXW0GQR1XS
A498 NYnae|YyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1mwVWlEPTB;NT6yNVI2OSEQvF2= M2rBRXNCVkeHUh?=
ES5 MoLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTVwNkGxO|gh|ryP MnLXV2FPT0WU
MDA-MB-157 M2D5bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjKbFJKSzVyPUWuOlY1PDNizszN MV7TRW5ITVJ?
NCI-H1623 NXO2c3VVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHWyWFNKSzVyPUWuPFM2PTZizszN MWjTRW5ITVJ?
RPMI-8866 NHHaTI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3J[XVKSzVyPUWuPFQ4QTJizszN NILidXBUSU6JRWK=
LC-1F MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTZwMEmyPVEh|ryP MVvTRW5ITVJ?
TCCSUP MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zjNWlEPTB;Nj62NFM1QSEQvF2= MV;TRW5ITVJ?
TT NGPUVmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PKVWlEPTB;OD6zN|AxQSEQvF2= NEe2dHdUSU6JRWK=
NCI-H1838 M1HITmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\ETWM2OD16LkWxO|MyKM7:TR?= M3O0e3NCVkeHUh?=
NCI-H322M M37ySGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTlwMU[yPFEh|ryP MXvTRW5ITVJ?
NCI-H187 MnHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTlwNUG4N|Uh|ryP MnzHV2FPT0WU
SBC-1 NVLrfVNrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkj2TWM2OD17LkmzOlU3KM7:TR?= M3nFT3NCVkeHUh?=
SCC-3 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDLTWM2OD1zMD61Olc6KM7:TR?= NXfxco9rW0GQR1XS
SW948 M2PxSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13oUWlEPTB;MUCuO|UyOSEQvF2= MU\TRW5ITVJ?
CPC-N Mmm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3ySZpKSzVyPUGxMlAxPyEQvF2= NXX2XlI{W0GQR1XS
TGBC24TKB Ml6yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTF|LkWyPUDPxE1? NGK1cVVUSU6JRWK=
NCI-H2452 M4\HVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPITWM2OD1zND63N{DPxE1? NIHVNI1USU6JRWK=
Hs-578-T NF7BO3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTF6LkW3OVkh|ryP NX\zfZBEW0GQR1XS
DV-90 M3TEbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTF6Lkm5OFUh|ryP NXLPRXdXW0GQR1XS
NCI-H1563 NH7YVYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;MTWM2OD1zOT63PFg5KM7:TR?= NXnxRotuW0GQR1XS
SW780 NIP0dmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTJzLkGzNVgh|ryP M3TFXnNCVkeHUh?=
NCI-H345 MoXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULvZnJJUUN3ME2yNU45Pzd7IN88US=> NIXnemRUSU6JRWK=
LB771-HNC Mnu1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDjXG5GUUN3ME2yNk41QDF|IN88US=> MYnTRW5ITVJ?
RT4 M1;Yd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7nbYhKSzVyPUKzMlMzQDJizszN MoHyV2FPT0WU
NCI-H82 MmXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTJ|LkW1NlYh|ryP M3PsVXNCVkeHUh?=
NCI-H524 NGDEe5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTJ2LkO4NVIh|ryP MnSwV2FPT0WU
SNU-C1 MkL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXrdYF{UUN3ME2yOE46OTB3IN88US=> NUfJcVFQW0GQR1XS
NCI-SNU-16 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TyXmlEPTB;NEiuN|E1OiEQvF2= NX3B[oVOW0GQR1XS

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

体内試験 Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]

お薦めの試験操作(参考用のみ)

キナーゼ試験:[3]
+ 展開

Kinase assay:

NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
細胞試験: [1]
+ 展開
  • 細胞株: Human gastric cancer cells NCI-N87
  • 濃度: 1 μM
  • 反応時間: 3 days
  • 実験の流れ: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.
    (参考用のみ)
動物試験:[3]
+ 展開
  • 動物モデル: Female NCr athymic mice bearing WM266.4 human melanoma xenografts
  • 製剤: In DMSO and diluted in sterile saline/Tween 20
  • 投薬量: 50 mg/kg
  • 投与方法: Administered via i.v. or i.p.
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 93 mg/mL (199.76 mM) warming
Ethanol 31 mg/mL (66.58 mM)
Water Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
1% DMSO+30% polyethylene glycol+1% Tween 80
混合させたのち直ちに使用することを推奨します。
30 mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 465.54
化学式

C26H31N3O5

CAS No. 747412-49-3
保管
in solvent
別名 VER-52296

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01922583 Completed Non-small Cell Lung Cancer (NSCLC) National Taiwan University Hospital January 2014 Phase 2
NCT01784640 Active not recruiting Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) January 31 2014 Phase 1
NCT01854034 Completed Non Small Cell Lung Cancer Massachusetts General Hospital July 2013 Phase 2
NCT01772797 Completed Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis June 2013 Phase 1
NCT01752400 Completed Non Small Cell Lung Cancer Massachusetts General Hospital January 2013 Phase 2
NCT01613950 Completed Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein Novartis Pharmaceuticals|Novartis December 2012 Phase 1

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

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Tags: Luminespib (AUY-922, NVP-AUY922)を買う | Luminespib (AUY-922, NVP-AUY922) ic50 | Luminespib (AUY-922, NVP-AUY922)供給者 | Luminespib (AUY-922, NVP-AUY922)を購入する | Luminespib (AUY-922, NVP-AUY922)費用 | Luminespib (AUY-922, NVP-AUY922)生産者 | オーダーLuminespib (AUY-922, NVP-AUY922) | Luminespib (AUY-922, NVP-AUY922)化学構造 | Luminespib (AUY-922, NVP-AUY922)分子量 | Luminespib (AUY-922, NVP-AUY922)代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID