Luminespib (AUY-922, NVP-AUY922)

製品コードS1069 別名:VER-52296

Luminespib (AUY-922, NVP-AUY922)化学構造

分子量(MW):465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

サイズ 価格(税別)  
JPY 53120.00
JPY 26560.00
JPY 44820.00
JPY 78020.00

カスタマーフィードバック(3)

  • U2OS_exo cells were incubated with AUY922 for 20 h at the indicated concentrations before stimulation with TNFα (30 ng/mL) for 30 min and immunostaining to detect NF-κB (p65). DMSO 1%, cells stimulated by TNFα in the absence of AUY922. Representative pictures used to quantify nuclear and cytoplasmic localization of NF-κB.

    Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

    J Biol Chem 2013 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

  • Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922  (ie, induction of HSP72 and depletion of client proteins such as ERBB2, CRAF and CDK4) in BT474 breast cancer cell line. GAPDH was used as loading control.

     

     

    2011 Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

製品安全説明書

HSP (e.g. HSP90)阻害剤の選択性比較

生物活性

製品説明 Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
ターゲット
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
体外試験

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CMK MoG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETobmpKSzVyPUCuNFAxOTJ3IN88US=> MUTTRW5ITVJ?
MV-4-11 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\OXI9KSzVyPUCuNFAxPTV6IN88US=> MoToV2FPT0WU
NALM-6 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHiUZRrUUN3ME2wMlAxODh2MjFOwG0> NWj5Znc2W0GQR1XS
HOS Ml\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfPOolKSzVyPUCuNFAyOzhizszN M1nicHNCVkeHUh?=
HT-144 NGD6O2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjGTWM2OD1yLkCwNVU2KM7:TR?= NFTkWWJUSU6JRWK=
SW1710 M2PhdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;VOnhOUUN3ME2wMlAxOTh4IN88US=> M{DDfXNCVkeHUh?=
TE-8 NHPHellIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\jRWNKSzVyPUCuNFAzOzdizszN MUXTRW5ITVJ?
ES1 M13LWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4njdmlEPTB;MD6wNFI3PiEQvF2= NIX5eYJUSU6JRWK=
CCF-STTG1 NYfX[HNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DjUGlEPTB;MD6wNFI6PyEQvF2= MoG4V2FPT0WU
PSN1 NWL6S|h[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\OeY53UUN3ME2wMlAxOzF6IN88US=> NV\NcGhLW0GQR1XS
CAL-51 M{LwcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\GWHZKSzVyPUCuNFA{OjVizszN NYDBN21JW0GQR1XS
MCF7 M3LSc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILlXFBKSzVyPUCuNFA{OzVizszN MkLaV2FPT0WU
SK-HEP-1 NF72[pdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHjOYpvUUN3ME2wMlAxOzN4IN88US=> MkH2V2FPT0WU
LCLC-103H Mo\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrreIdKSzVyPUCuNFA1OyEQvF2= MXPTRW5ITVJ?
HMV-II NGH1W|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;uNWlEPTB;MD6wNFQ1QSEQvF2= NUnnUIQ5W0GQR1XS
MES-SA MkXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrrWHFWUUN3ME2wMlAxPDV{IN88US=> M2fx[nNCVkeHUh?=
SK-LMS-1 MmnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMEC0OVgh|ryP MX3TRW5ITVJ?
639-V M{PqcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMEC0PFUh|ryP MoXXV2FPT0WU
SIG-M5 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEW0emZKSzVyPUCuNFA1QDlizszN Ml7HV2FPT0WU
LOUCY MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjYRmNKSzVyPUCuNFA2ODVizszN NUS5enU2W0GQR1XS
HSC-2 M2PEdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPu[241UUN3ME2wMlAxPTF6IN88US=> NXHTbnlNW0GQR1XS
EW-13 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDaTWM2OD1yLkCwOVE5KM7:TR?= NV\tNlVsW0GQR1XS
RT-112 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjIRZY2UUN3ME2wMlAxPTN3IN88US=> MXrTRW5ITVJ?
NKM-1 NVvk[o1[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPMOnRYUUN3ME2wMlAxPTR5IN88US=> M{XMXnNCVkeHUh?=
KYSE-180 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HzbmlEPTB;MD6wNFU5PiEQvF2= M1vmc3NCVkeHUh?=
SW1783 NF7WfXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfTeZpxUUN3ME2wMlAxPTlzIN88US=> MnvCV2FPT0WU
A431 NWGwT3NsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4S1dmlEPTB;MD6wNFYxPyEQvF2= NEfwem9USU6JRWK=
SK-OV-3 M1roPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW[wS5dXUUN3ME2wMlAxPjNizszN NIrQTVdUSU6JRWK=
RPMI-7951 M1vTRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnlcld5UUN3ME2wMlAxPjNzIN88US=> NF3ydXBUSU6JRWK=
Capan-2 NFvH[pdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvsTWM2OD1yLkCwOlM5KM7:TR?= NIP1OIFUSU6JRWK=
HSC-3 NXK1fIdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTRTWM2OD1yLkCwOlQyKM7:TR?= NYnKR4t{W0GQR1XS
786-0 M2[xTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwMEC2OlMh|ryP M3v2dHNCVkeHUh?=
Daoy MnLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PrW2lEPTB;MD6wNFY6PSEQvF2= MXzTRW5ITVJ?
KGN NWizd3NET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXndlN2UUN3ME2wMlAxPzB|IN88US=> M3vGdHNCVkeHUh?=
EW-16 NISzcIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LUZ2lEPTB;MD6wNFc1QSEQvF2= NF7nUHlUSU6JRWK=
EW-7 NWjyWmh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwMEC3OVQh|ryP M1y0c3NCVkeHUh?=
IGROV-1 M1jLbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlH6TWM2OD1yLkCwPFE1KM7:TR?= M3TMVHNCVkeHUh?=
8505C MnHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVn0SI5wUUN3ME2wMlAxQDJzIN88US=> M17HTnNCVkeHUh?=
RKO MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTDTWM2OD1yLkCwPFI3KM7:TR?= MWXTRW5ITVJ?
GDM-1 NF3OW5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwMEC4OEDPxE1? MmrQV2FPT0WU
IST-MEL1 NUfxNplFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXZWnNvUUN3ME2wMlAxQDV{IN88US=> MknSV2FPT0WU
RPMI-6666 NX3neY92T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XOZ2lEPTB;MD6wNFg2OiEQvF2= NHPHU5lUSU6JRWK=
SNG-M Mny1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMEC4OVYh|ryP NX\6NWM5W0GQR1XS
KS-1 M2TLXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPTUZhqUUN3ME2wMlAxQDV7IN88US=> Mn7KV2FPT0WU
RXF393 MoHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrFNlloUUN3ME2wMlAxQDZizszN NGDnSpNUSU6JRWK=
CAL-12T MnvMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGf3XJhKSzVyPUCuNFA6OjJizszN M1fue3NCVkeHUh?=
BFTC-905 M1HWXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMEC5N|gh|ryP MmjYV2FPT0WU
SK-MES-1 NVK2R5dzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLpTWM2OD1yLkCwPVQ2KM7:TR?= M4\GdHNCVkeHUh?=
BB30-HNC MoLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHvV4drUUN3ME2wMlAxQTV{IN88US=> MXfTRW5ITVJ?
AN3-CA M2HhbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmmyTWM2OD1yLkCxNFE4KM7:TR?= MXjTRW5ITVJ?
EFO-27 NEO3ZYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMEGwNVch|ryP MYDTRW5ITVJ?
G-401 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH:0UHlKSzVyPUCuNFExOjVizszN M4rqWnNCVkeHUh?=
BPH-1 M4rNUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrMWldZUUN3ME2wMlAyODNizszN NIHnRlBUSU6JRWK=
NCI-H727 NGP5PVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUX4OWFGUUN3ME2wMlAyODNizszN M{n3enNCVkeHUh?=
SNU-423 MmX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;jT2lEPTB;MD6wNVA2OyEQvF2= NVKyR|dwW0GQR1XS
KYSE-270 NHqzfVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfLTWM2OD1yLkCxNFU6KM7:TR?= NIXzOmJUSU6JRWK=
AGS NW\MVZlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDCeJlKSzVyPUCuNFExPjFizszN MWLTRW5ITVJ?
NCI-H2228 MnrLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzRTWM2OD1yLkCxNFY1KM7:TR?= NYjLT|FFW0GQR1XS
SW954 NEjFXphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnS2TWM2OD1yLkCxNFcyKM7:TR?= MWLTRW5ITVJ?
769-P MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXSS3pKSzVyPUCuNFExPzNizszN NXW2OZM5W0GQR1XS
BB49-HNC MoX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XtVmlEPTB;MD6wNVA4PyEQvF2= MnPGV2FPT0WU
IA-LM MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwMEGwPFYh|ryP MoPhV2FPT0WU
NB69 M3fH[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PUcmlEPTB;MD6wNVExOiEQvF2= NHXUNFRUSU6JRWK=
C8166 NG\Ce3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2C5R2lEPTB;MD6wNVEzQSEQvF2= Mne5V2FPT0WU
NCI-H1299 NUmxUGxuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwMEGxOVQh|ryP NXPKWHVlW0GQR1XS
YKG-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMEGxOkDPxE1? M1X0d3NCVkeHUh?=
PANC-03-27 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\RTJdKSzVyPUCuNFEyPjJizszN MoKyV2FPT0WU
YT M{[1ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjYXJdKSzVyPUCuNFEyPzlizszN NGfNfnlUSU6JRWK=
CAL-85-1 NWLTWY9jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTHTWM2OD1yLkCxNVkzKM7:TR?= NXu0dnR7W0GQR1XS
GT3TKB M1i2W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwMEGyNFIh|ryP MkHLV2FPT0WU
BB65-RCC MlPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfXTWM2OD1yLkCxNlA1KM7:TR?= NVfPUpprW0GQR1XS
ES6 NV[0dXBTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwMEGyOlEh|ryP MVvTRW5ITVJ?
MHH-ES-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzLfpBKSzVyPUCuNFEzPjNizszN NIXmb3BUSU6JRWK=
QIMR-WIL NH23b4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTMcIpJUUN3ME2wMlAyOjZ7IN88US=> NGjiZXRUSU6JRWK=
SNU-C2B NWjzN2pIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwMEGyO|Ih|ryP MXXTRW5ITVJ?
OCI-AML2 Mn60S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\OXmlEPTB;MD6wNVI5OSEQvF2= MnjXV2FPT0WU
DU-145 NISy[JNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3HN2J{UUN3ME2wMlAyOjlizszN M{fwbXNCVkeHUh?=
SW982 MkDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo[0TWM2OD1yLkCxNlk{KM7:TR?= NEDpNYRUSU6JRWK=
MFH-ino NV\aclNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnEdmluUUN3ME2wMlAyOjl|IN88US=> NIrxTlNUSU6JRWK=
A427 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMEGyPVkh|ryP M1vsfHNCVkeHUh?=
LCLC-97TM1 Mm\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXxTWM2OD1yLkCxN{DPxE1? MV3TRW5ITVJ?
AM-38 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;rTWM2OD1yLkCxN|AzKM7:TR?= MlXtV2FPT0WU
K5 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkT2TWM2OD1yLkCxN|A5KM7:TR?= M3jhT3NCVkeHUh?=
T84 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjKS2FKSzVyPUCuNFE{OzFizszN MYXTRW5ITVJ?
TE-15 MoTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfTfXRKSzVyPUCuNFE{OzZizszN M2S0bnNCVkeHUh?=
NCI-H460 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrrTWM2OD1yLkCxN|M3KM7:TR?= MVfTRW5ITVJ?
NTERA-S-cl-D1 M1mwTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHf2dmNKSzVyPUCuNFE{OzlizszN NHTlTnNUSU6JRWK=
KYSE-450 NWDtfVdjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHUe25YUUN3ME2wMlAyOzR7IN88US=> NUXFZY5VW0GQR1XS
H4 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TMfGlEPTB;MD6wNVM3PiEQvF2= MWnTRW5ITVJ?
LC-2-ad NI[5PVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMEGzO{DPxE1? M{nubnNCVkeHUh?=
GAMG Mn7CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPsXZkyUUN3ME2wMlAyOzdzIN88US=> M{[4[XNCVkeHUh?=
TK10 NELGXHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwMEGzPFIh|ryP MonQV2FPT0WU
NCI-H2122 NFzxdodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjxTWM2OD1yLkCxN|g1KM7:TR?= NYGyR2FTW0GQR1XS
KM12 NHrnRWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmi4TWM2OD1yLkCxN|k6KM7:TR?= NGXJTlhUSU6JRWK=
CAL-39 NELHNWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjxRnYxUUN3ME2wMlAyPDJizszN NHX1R2NUSU6JRWK=
RPMI-2650 NETPe4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13yUmlEPTB;MD6wNVQ{OiEQvF2= NV:3PHVqW0GQR1XS
KYSE-510 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwMEG0OFIh|ryP M2e5cHNCVkeHUh?=
KALS-1 NXr1ZmtYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33W[2lEPTB;MD6wNVQ3PiEQvF2= MXXTRW5ITVJ?
NCI-H1648 M3fEZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwMEG0PVkh|ryP NVG3[o1jW0GQR1XS
ES4 MknLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVK3UmRvUUN3ME2wMlAyPTB{IN88US=> MmfvV2FPT0WU
C-33-A NEHVRpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMEG1NFkh|ryP MmXpV2FPT0WU
MIA-PaCa-2 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwMEG1NFkh|ryP NULifVlWW0GQR1XS
Becker NWG4eHBYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrYTVZkUUN3ME2wMlAyPTF2IN88US=> M3y5bnNCVkeHUh?=
HOP-62 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2L1WWlEPTB;MD6wNVU1OiEQvF2= NW\vfmY5W0GQR1XS
TE-1 NInyU4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGr5fYtKSzVyPUCuNFE2QDFizszN MlnQV2FPT0WU
KYSE-410 NGPOZoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHLXW9QUUN3ME2wMlAyPTh4IN88US=> NVT2[3ppW0GQR1XS
NOS-1 MlThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fPfWlEPTB;MD6wNVU6OyEQvF2= M{SzSnNCVkeHUh?=
MEL-HO M4S0VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTJTWNvUUN3ME2wMlAyPjR|IN88US=> NEPSOnhUSU6JRWK=
NCI-H1650 NH3CeWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\PTWM2OD1yLkCxOlQ3KM7:TR?= MoHpV2FPT0WU
VMRC-RCZ MlvXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwMEG2OVEh|ryP NVrkeVllW0GQR1XS
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RS4-11 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfuVWJjUUN3ME2wMlA{Ozh|IN88US=> M3XzU3NCVkeHUh?=
JiyoyeP-2003 M4e3fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrTcJlKSzVyPUCuNFM{QDhizszN MVvTRW5ITVJ?
BL-70 NGXZb|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlX6TWM2OD1yLkCzN|g6KM7:TR?= NEHZTXJUSU6JRWK=
OS-RC-2 NHXDOJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwMEOzPVYh|ryP M4q4VHNCVkeHUh?=
SF268 MnPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3YdoFKSzVyPUCuNFM1ODFizszN MUfTRW5ITVJ?
BV-173 NGXQbZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwMEO0NlYh|ryP MVnTRW5ITVJ?
DMS-273 NHTzdGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwMEO0O|kh|ryP MVzTRW5ITVJ?
22RV1 NFrKWGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1T6TWlEPTB;MD6wN|UxPyEQvF2= MUXTRW5ITVJ?
ES8 M{P0bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMEO1N|gh|ryP MlvBV2FPT0WU
KYSE-150 Mkj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHobXlHUUN3ME2wMlA{PjB6IN88US=> MmXZV2FPT0WU
HCC1569 MlfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zHV2lEPTB;MD6wN|YxQCEQvF2= MUTTRW5ITVJ?
NB5 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3n5PWlEPTB;MD6wN|YyOyEQvF2= MonhV2FPT0WU
G-402 NXXmUlU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PlWGlEPTB;MD6wN|YyPCEQvF2= MnjyV2FPT0WU
NCI-H1693 MmW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjlZnFKSzVyPUCuNFM3OTdizszN Mk\GV2FPT0WU
LB2241-RCC MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEn3OodKSzVyPUCuNFM3PDJizszN NV;mdIFuW0GQR1XS
KP-4 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwMEO2OlMh|ryP Mlf2V2FPT0WU
ML-2 M2rHb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjIOIxYUUN3ME2wMlA{PjdzIN88US=> MXjTRW5ITVJ?
KU812 NGjlXGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMEO2PFQh|ryP NIG3dHBUSU6JRWK=
LS-411N NWjGSlJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwMEO3N|Eh|ryP MVnTRW5ITVJ?
OAW-42 M{T1Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMEO3OFch|ryP NYPrUWFxW0GQR1XS
HCC38 NVfscHJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnW0TWM2OD1yLkCzO|cyKM7:TR?= MmnGV2FPT0WU
Ca-Ski Mn7XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnhTWM2OD1yLkCzO|g1KM7:TR?= MlHuV2FPT0WU
Calu-3 NFz6[FhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzMTWM2OD1yLkCzO|g6KM7:TR?= MX;TRW5ITVJ?
KYSE-70 NWnXXHBpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjscnQ4UUN3ME2wMlA{QDF{IN88US=> NITHfGxUSU6JRWK=
D-392MG NYjLRZI1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTBwMEO4OFIh|ryP NWnqVpUzW0GQR1XS
OVCAR-4 NGHG[ZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfSTWM2OD1yLkCzPFU5KM7:TR?= NVPBRnRYW0GQR1XS
Detroit562 NI\rN5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLw[pBUUUN3ME2wMlA{QDd{IN88US=> MnvBV2FPT0WU
HEL M1iwVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7RT3FKSzVyPUCuNFM5QTFizszN NHvodm9USU6JRWK=
MONO-MAC-6 NF\mSIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPqcYZKSzVyPUCuNFM5QTNizszN NUO0N5hVW0GQR1XS
LoVo NEKxO2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTITWM2OD1yLkCzPVM{KM7:TR?= NV;6dGxLW0GQR1XS
U-2-OS NUDKfVdlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1SxPGlEPTB;MD6wN|k{PSEQvF2= MkLHV2FPT0WU
A172 M3:2cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHMTWM2OD1yLkCzPVUh|ryP MmrDV2FPT0WU
OCUB-M NYD2[mlxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorSTWM2OD1yLkCzPVYyKM7:TR?= M4H3[HNCVkeHUh?=
SW48 M1L6dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nme2lEPTB;MD6wOFA{OSEQvF2= MnPWV2FPT0WU
HC-1 NEP1cIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLyTWM2OD1yLkC0NFY6KM7:TR?= MUfTRW5ITVJ?
KOSC-2 M4i5dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDINoVKSzVyPUCuNFQyOSEQvF2= MlPXV2FPT0WU
HDLM-2 NHm3RoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHzRo1KSzVyPUCuNFQyOTRizszN NGrxfIpUSU6JRWK=
CTV-1 M2PBXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMESxNVYh|ryP M1PFTnNCVkeHUh?=
SH-4 NFrEUW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljMTWM2OD1yLkC0NVQyKM7:TR?= M{PxUHNCVkeHUh?=
SW756 M3HvVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPWWGhNUUN3ME2wMlA1OTV5IN88US=> NGDFW5dUSU6JRWK=
GCT MmjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDRbGJjUUN3ME2wMlA1OTZzIN88US=> MmH4V2FPT0WU
CHL-1 Ml;3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFX3OoFKSzVyPUCuNFQyPjlizszN NIrUcoRUSU6JRWK=
LAMA-84 M{m3dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TOXGlEPTB;MD6wOFE4OSEQvF2= NI\GRYNUSU6JRWK=
LS-1034 M3GwN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPwclhKSzVyPUCuNFQyQTFizszN MXHTRW5ITVJ?
NCI-H358 NHvyXYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTBwMESyNVIh|ryP NXfO[JhWW0GQR1XS
NB13 MmrLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\NTJdKSzVyPUCuNFQzOjdizszN M{m4e3NCVkeHUh?=
TE-9 NUf3bFQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofqTWM2OD1yLkC0NlM4KM7:TR?= M{H1RnNCVkeHUh?=
OE33 NWi1Z41RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwMESyOFEh|ryP M4Pnc3NCVkeHUh?=
CAL-120 M3\ucGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfSUWNKSzVyPUCuNFQzPDFizszN M{jEc3NCVkeHUh?=
DJM-1 Ml7NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMESyO|Ih|ryP NVzN[XZmW0GQR1XS
SK-MEL-24 MmTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnX3TWM2OD1yLkC0Nlg{KM7:TR?= M4PvenNCVkeHUh?=
VA-ES-BJ MmO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXFNJdKSzVyPUCuNFQzQTJizszN MVvTRW5ITVJ?
MMAC-SF NV3CS3FHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTBwMESyPVch|ryP MXrTRW5ITVJ?
MZ7-mel MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMESzN{DPxE1? NYTae3JOW0GQR1XS
BxPC-3 NHT2bpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4O3[mlEPTB;MD6wOFM1OSEQvF2= MUXTRW5ITVJ?
HT-29 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHUTWM2OD1yLkC0N|U4KM7:TR?= NH\uclhUSU6JRWK=
SK-MEL-30 NHvTbVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LP[mlEPTB;MD6wOFM3OiEQvF2= MoPWV2FPT0WU
CAL-33 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vXUGlEPTB;MD6wOFM4PSEQvF2= MWHTRW5ITVJ?
COLO-680N NGr5OZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwMES0NFch|ryP MnThV2FPT0WU
NH-12 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMES0OEDPxE1? NIPvT4VUSU6JRWK=
HCC1937 M2\6dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvtTWM2OD1yLkC0OFU3KM7:TR?= MkPuV2FPT0WU
IMR-5 M1\Wbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\PbWlEPTB;MD6wOFQ6KM7:TR?= MmD0V2FPT0WU
MC-CAR MnHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTBwMES1Olkh|ryP MoL5V2FPT0WU
NCI-H747 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DteWlEPTB;MD6wOFU4KM7:TR?= MmiyV2FPT0WU
NCI-H1792 M1Gxemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTBwMES1PFEh|ryP NWXWWGhlW0GQR1XS
SW13 NGfjcmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwMES1PUDPxE1? MkL6V2FPT0WU
MLMA M4DPOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;ZU5lKSzVyPUCuNFQ3ODlizszN NUHMbWR7W0GQR1XS
U251 M1TpPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M163bGlEPTB;MD6wOFc3OyEQvF2= MmHNV2FPT0WU
U031 MmfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LvPGlEPTB;MD6wOFc4OSEQvF2= MmPVV2FPT0WU
ME-180 NXvHd4xyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHsTWM2OD1yLkC0O|gzKM7:TR?= NHfIUm5USU6JRWK=
SK-MEL-3 M33ofmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwMES4NFIh|ryP M3jqSnNCVkeHUh?=
MOLT-4 NImzcXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\OTWM2OD1yLkC0PFA{KM7:TR?= MoPGV2FPT0WU
PF-382 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwMES4NlYh|ryP NWDZfo1jW0GQR1XS
NUGC-3 MlvIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DIUmlEPTB;MD6wOFgzPyEQvF2= MoXQV2FPT0WU
NCI-H1417 NVHZOFdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTBwMES4PUDPxE1? NHzYUGlUSU6JRWK=
COLO-205 NVvqOoVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMES5NVkh|ryP MWXTRW5ITVJ?
TE-441-T MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4ntcGlEPTB;MD6wOFk{KM7:TR?= NGrYV2hUSU6JRWK=
MKN1 NWLVS2ZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jlNGlEPTB;MD6wOFk{KM7:TR?= MXXTRW5ITVJ?
UM-UC-3 NHeycJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnuyTWM2OD1yLkC0PVUh|ryP M4\YUXNCVkeHUh?=
SF126 MlHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMEWwNUDPxE1? NILlS|ZUSU6JRWK=
LB1047-RCC M4TnWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHmTWM2OD1yLkC1NFMyKM7:TR?= MoXoV2FPT0WU
A253 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHqeoZkUUN3ME2wMlA2ODV{IN88US=> NXvGNHY1W0GQR1XS
NCI-H1963 M1rp[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDoemM2UUN3ME2wMlA2OTd4IN88US=> NXryWoV6W0GQR1XS
VM-CUB-1 NXT2OZVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDUTWM2OD1yLkC1N|EyKM7:TR?= MYnTRW5ITVJ?
T-24 M4rWbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\Q[pNVUUN3ME2wMlA2Ozh2IN88US=> NFrDNIFUSU6JRWK=
K-562 M{PCTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXUOmFKSzVyPUCuNFU{QDdizszN MYXTRW5ITVJ?
ARH-77 M1vWUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3HSoJCUUN3ME2wMlA2Ozl3IN88US=> NFv0N2pUSU6JRWK=
CA46 MlrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknLTWM2OD1yLkC1OFMh|ryP NV71fWVqW0GQR1XS
HCC70 M2[wR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHPTWM2OD1yLkC1OFUzKM7:TR?= Ml;IV2FPT0WU
ST486 NWfnNYpxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37aXWlEPTB;MD6wOVUzPSEQvF2= NIqzXmNUSU6JRWK=
COLO-741 NXrBNHliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MluzTWM2OD1yLkC1OVMyKM7:TR?= NHPkbYVUSU6JRWK=
SK-PN-DW M370Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33n[mlEPTB;MD6wOVU5QCEQvF2= M4PY[nNCVkeHUh?=
BL-41 Ml;CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwMEW1PVYh|ryP MVnTRW5ITVJ?
D-263MG NXq1ZlBNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTBwMEW2PFMh|ryP MVLTRW5ITVJ?
KE-37 Mkf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWe5VVk5UUN3ME2wMlA2Pjh|IN88US=> NIH0[llUSU6JRWK=
LU-134-A NITUdHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF30U3VKSzVyPUCuNFU4OTVizszN Ml3VV2FPT0WU
HCC2157 NUnhRm5lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3uySGlEPTB;MD6wOVc{OyEQvF2= MVPTRW5ITVJ?
GAK M1XWbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXMOI1WUUN3ME2wMlA2PzN2IN88US=> NH3LSnhUSU6JRWK=
IST-SL2 M1rxVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mme0TWM2OD1yLkC1O|Q{KM7:TR?= NU[4XJB[W0GQR1XS
KMOE-2 M4r0XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjhW5pKSzVyPUCuNFU4PDlizszN Mn;zV2FPT0WU
SW1573 MlzFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nhb2lEPTB;MD6wOVgxOiEQvF2= MnHMV2FPT0WU
SCC-9 NHOzRllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnKSIxUUUN3ME2wMlA2QDdizszN MkDVV2FPT0WU
MDA-MB-361 MmP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonnTWM2OD1yLkC1PFczKM7:TR?= MY\TRW5ITVJ?
BHT-101 NH3yOGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPQZpBKSzVyPUCuNFU5PzZizszN NWDERYdJW0GQR1XS
NCI-H1770 MoT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzqTWM2OD1yLkC1PFc6KM7:TR?= MW\TRW5ITVJ?
UACC-893 NHX1WW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwMEW4PVYh|ryP MnrPV2FPT0WU
NCI-H226 NHrueWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mki4TWM2OD1yLkC1PVg5KM7:TR?= NHy2eJdUSU6JRWK=
HLE NELOfVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HONGlEPTB;MD6wOlA5OiEQvF2= MVrTRW5ITVJ?
NCI-H1703 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrNRXNJUUN3ME2wMlA3OTd6IN88US=> Mn\aV2FPT0WU
KURAMOCHI MkXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnYOZJbUUN3ME2wMlA3OTh7IN88US=> NX;pV2FqW0GQR1XS
RH-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwME[yN{DPxE1? M2DqPHNCVkeHUh?=
DSH1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwME[yO{DPxE1? NF3PTIZUSU6JRWK=
CAMA-1 MofUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwME[zNFMh|ryP MXLTRW5ITVJ?
NCI-H1437 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwME[zNlgh|ryP MXnTRW5ITVJ?
HuP-T4 NXXQWJl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;1ZWlEPTB;MD6wOlU5PiEQvF2= MmKzV2FPT0WU
HCT-15 NFHXPJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLVTWM2OD1yLkC2OVk4KM7:TR?= NWnh[FYxW0GQR1XS
NCCIT Mn7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwME[2NFQh|ryP NVrKPI85W0GQR1XS
BOKU MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH:2ZW1KSzVyPUCuNFY3PzRizszN NXX2dFhlW0GQR1XS
FADU NFntNYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwME[3OFUh|ryP MVjTRW5ITVJ?
SUP-T1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwME[3OkDPxE1? NETJWWlUSU6JRWK=
L-363 NFLDPWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nZT2lEPTB;MD6wOlkxOSEQvF2= Mnr2V2FPT0WU
KNS-81-FD MljGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwME[5NVgh|ryP NWTuW2pZW0GQR1XS
SU-DHL-1 NHi2N41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3r5SWlEPTB;MD6wOlkzKM7:TR?= NXOzfIZbW0GQR1XS
HuH-7 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjF[Io{UUN3ME2wMlA4ODN3IN88US=> NHK1Z|BUSU6JRWK=
BT-474 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3i0d2lEPTB;MD6wO|A3OSEQvF2= NV[1O4JJW0GQR1XS
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NCI-H69 NHPJc5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DUZmlEPTB;MD6yO|IxOSEQvF2= M3fSeXNCVkeHUh?=
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NCI-H1694 M4X4bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3q4fWlEPTB;MD6yO|c{OyEQvF2= NXnyOW5OW0GQR1XS
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NCI-H510A NVPEbI45T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWWxeGFmUUN3ME2wMlI6OzB2IN88US=> M1vGTHNCVkeHUh?=
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LB373-MEL-D NVHXe|VOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3X3eGlEPTB;MD6yPVQ{OSEQvF2= NXXUNXZlW0GQR1XS
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NCI-H446 NHLmdGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwMkm5NlEh|ryP MX\TRW5ITVJ?
L-540 M2T4T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwM{CwPFkh|ryP NF\2bYlUSU6JRWK=
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BT-20 MkXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1L3dGlEPTB;MD6zNVA6QSEQvF2= NUPtVW5iW0GQR1XS
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MDA-MB-175-VII NE\PdJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwM{KzOFgh|ryP MXPTRW5ITVJ?
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COLO-829 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7rTWM2OD1yLkO0OFUzKM7:TR?= MoK1V2FPT0WU
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NCI-H719 NG[0XYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HTfWlEPTB;MD6zOVEzPCEQvF2= Mk\tV2FPT0WU
MFE-280 NHf2em5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwM{W3NVUh|ryP NVnrfpNWW0GQR1XS
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LB2518-MEL MmHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXNemxKSzVyPUCuOFA5PzJizszN NWDGSmJJW0GQR1XS
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NCI-H1882 MlviS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jwTmlEPTB;MD60NVc5PCEQvF2= M4CwO3NCVkeHUh?=
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UACC-812 M2XMe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnXTWM2OD1yLkS2O|c3KM7:TR?= NXnS[mo{W0GQR1XS
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RPMI-8402 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInydlFKSzVyPUCuOVIzODdizszN MW\TRW5ITVJ?
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KG-1 MmfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwNUW5PFQh|ryP NH3HXVFUSU6JRWK=
C32 NXrXSGJnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLSSIVKSzVyPUCuOVc{OTNizszN MVLTRW5ITVJ?
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NCI-H2126 MojQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwNkOxOVIh|ryP NWDO[oQ5W0GQR1XS
HCC1954 NYrmW3pKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnDTWM2OD1yLk[0O|I3KM7:TR?= MX\TRW5ITVJ?
WM-115 NVy4XpE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTBwNkWwPVIh|ryP M1z2TnNCVkeHUh?=
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KY821 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTBwN{CyNlkh|ryP NFr2dW5USU6JRWK=
SIMA MoXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwN{G3NVkh|ryP NFfiXVZUSU6JRWK=
RCC10RGB Ml3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XzNGlEPTB;MD63NVkyQCEQvF2= NUDLZWNPW0GQR1XS
LN-405 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPGT5dKSzVyPUCuO|Q{PiEQvF2= M{\IXnNCVkeHUh?=
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SCLC-21H MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TnRWlEPTB;MD63OlkxOyEQvF2= MWDTRW5ITVJ?
DMS-79 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGq2Z4NKSzVyPUCuO|c5PDVizszN MlX4V2FPT0WU
EC-GI-10 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwN{e5O|Uh|ryP MmH5V2FPT0WU
KNS-42 M2nDSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7JWZpHUUN3ME2wMlc5QDNzIN88US=> MUPTRW5ITVJ?
SNU-475 NW\XXZJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHUXnF5UUN3ME2wMlc6OjB{IN88US=> MYPTRW5ITVJ?
SF539 NEPkdmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1P5UGlEPTB;MD63PVkzPSEQvF2= NUf2cXlNW0GQR1XS
SW1417 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfVRmNxUUN3ME2wMlgyOzN7IN88US=> NH:1Vm5USU6JRWK=
ATN-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwOEWxNVUh|ryP MnzSV2FPT0WU
PLC-PRF-5 NE\TZ2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwOEi0O|Uh|ryP NIflVIdUSU6JRWK=
HT-3 M1r6cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwOEm0NkDPxE1? NFvXWGJUSU6JRWK=
MDA-MB-453 MnrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XBfGlEPTB;MD65NFMxPCEQvF2= MW\TRW5ITVJ?
HAL-01 M3niTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTZTWM2OD1yLkm5N|c6KM7:TR?= MVzTRW5ITVJ?
NCI-H1993 NF3EZ3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTFwMES2OVch|ryP NW\0WoVGW0GQR1XS
NCI-H2227 NGfHOlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7TemtOUUN3ME2xMlA1QThzIN88US=> NXzxUFFEW0GQR1XS
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NCI-H64 NU\sTYJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvsblVKSzVyPUGuNVU1OiEQvF2= MlfhV2FPT0WU
SW1463 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;zWZJKSzVyPUGuNVg{PDlizszN NFHZfVlUSU6JRWK=
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TALL-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTFwMkWxOlUh|ryP Ml71V2FPT0WU
RO82-W-1 NXrnZlRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTFwM{OzN|kh|ryP M3TQRXNCVkeHUh?=
NCI-H1581 MmnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rwemlEPTB;MT6zOVY5PyEQvF2= M3K0T3NCVkeHUh?=
NCI-H748 NVjQU3g3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nMUmlEPTB;MT6zOVc{QCEQvF2= MnmyV2FPT0WU
HCC1187 NX72T3pqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXtTWM2OD1zLkW1OVIzKM7:TR?= MVPTRW5ITVJ?
EoL-1-cell NFfxe3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknMTWM2OD1zLkW4PFg6KM7:TR?= MmXaV2FPT0WU
HuO-3N1 NXuwWnlOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTFwOEO0NVIh|ryP NWnhPII1W0GQR1XS
NCI-H1793 NV;SRmZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkT1TWM2OD1zLki3OVk{KM7:TR?= MWHTRW5ITVJ?
Caov-3 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGn1OXRKSzVyPUKuNFA3OjVizszN MX3TRW5ITVJ?
JAR MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUP3UYtxUUN3ME2yMlA4QTJizszN MUDTRW5ITVJ?
SK-MEL-28 Mmj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmH6TWM2OD1{LkG4NFk5KM7:TR?= MXXTRW5ITVJ?
EM-2 NX7uWmg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTJwMkCyPVMh|ryP MnvYV2FPT0WU
Mewo M{LmWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTJwMkKyOlUh|ryP MVjTRW5ITVJ?
NCI-H720 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTJwMk[1PFUh|ryP MnT6V2FPT0WU
CAL-54 M4\Pemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTJwMk[3PVUh|ryP M2nKenNCVkeHUh?=
MC116 NVy2V4NtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4myZ2lEPTB;Mj6zOlM6PyEQvF2= NV3DXHdyW0GQR1XS
DG-75 NXe5[llLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGqwc45KSzVyPUKuOFg2PzZizszN MXjTRW5ITVJ?
HCC1143 NGjpXoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfzeZNKSzVyPUKuOVA3PThizszN NIjpSZRUSU6JRWK=
FTC-133 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPqTWM2OD1{LkWzOlg6KM7:TR?= NUjsPWpQW0GQR1XS
AsPC-1 NXvJ[m9OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvKdmdDUUN3ME2yMlU{QTJ7IN88US=> MYLTRW5ITVJ?
NCI-H889 M4\BZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnOcVZKSzVyPUKuOVY4ODZizszN M13CNHNCVkeHUh?=
HT55 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF70dY9KSzVyPUKuOlIxOTlizszN M{[2bXNCVkeHUh?=
UMC-11 NVjmeJhKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnrTWM2OD1{Lke4O|E2KM7:TR?= NGDjR|NUSU6JRWK=
P12-ICHIKAWA M2T6Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HNO2lEPTB;Mj64NlA1PiEQvF2= M{PmbnNCVkeHUh?=
HCC1395 Mlm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHMclBKSzVyPUKuPVg3ODJizszN NEXZN2hUSU6JRWK=
D-283MED MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXzVHp5UUN3ME2zMlE5QTN5IN88US=> NGjK[5FUSU6JRWK=
COLO-800 NXLjOml4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLBPI9KSzVyPUOuN|M5QTdizszN NUXMfIMyW0GQR1XS
MFM-223 NGr2[5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPLVHk2UUN3ME2zMlM3ODl5IN88US=> M{XRbHNCVkeHUh?=
TE-5 NY\lWVdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoS3TWM2OD12LkW2NVQ4KM7:TR?= M2DmZXNCVkeHUh?=
NCI-H209 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTRwN{i1O|Ih|ryP MV3TRW5ITVJ?
SiHa MoL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\qbGlEPTB;ND65OVIxOyEQvF2= NV3XbmpyW0GQR1XS
NCI-H1395 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDJeXVKSzVyPUWuNVA3OzNizszN NYHnVWpRW0GQR1XS
A498 NWn2U2tlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorGTWM2OD13LkKxNlUyKM7:TR?= NUW5VYNzW0GQR1XS
ES5 NYjSe5k1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTVwNkGxO|gh|ryP NWPJTHZJW0GQR1XS
MDA-MB-157 NFPGOIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TyWmlEPTB;NT62OlQ1OyEQvF2= MnvVV2FPT0WU
NCI-H1623 NFHxVWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTVwOEO1OVYh|ryP M4LQVnNCVkeHUh?=
RPMI-8866 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrEZ5d2UUN3ME21Mlg1Pzl{IN88US=> MUfTRW5ITVJ?
LC-1F NUPqelFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HLNGlEPTB;Nj6wPVI6OSEQvF2= NVPCR2o5W0GQR1XS
TCCSUP NGPTZ2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTZwNkCzOFkh|ryP NEXHXoZUSU6JRWK=
TT NXyw[G96T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPYTWM2OD16LkOzNFA6KM7:TR?= M3GxWnNCVkeHUh?=
NCI-H1838 Ml3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkixTWM2OD16LkWxO|MyKM7:TR?= M1Tzc3NCVkeHUh?=
NCI-H322M MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7YXmFKSzVyPUmuNVYzQDFizszN MkHCV2FPT0WU
NCI-H187 NVjNcmJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\4dWlEPTB;OT61NVg{PSEQvF2= NVj2endmW0GQR1XS
SBC-1 M2Padmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjmcZk2UUN3ME25Mlk{PjV4IN88US=> MXnTRW5ITVJ?
SCC-3 NXz4RphWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TNTWlEPTB;MUCuOVY4QSEQvF2= M{[4U3NCVkeHUh?=
SW948 NUfI[217T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXMUmRJUUN3ME2xNE44PTFzIN88US=> MoC2V2FPT0WU
CPC-N MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XTcmlEPTB;MUGuNFA4KM7:TR?= MoraV2FPT0WU
TGBC24TKB MmPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTF|LkWyPUDPxE1? M1Tve3NCVkeHUh?=
NCI-H2452 M3P0XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnLOmxKSzVyPUG0Mlc{KM7:TR?= M1LSdXNCVkeHUh?=
Hs-578-T NX7PWZFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWf0[oRXUUN3ME2xPE42PzV7IN88US=> NEjLTmhUSU6JRWK=
DV-90 Ml\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3tV5Y3UUN3ME2xPE46QTR3IN88US=> NWjmXYx7W0GQR1XS
NCI-H1563 NYHNclZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHZTWM2OD1zOT63PFg5KM7:TR?= MnG5V2FPT0WU
SW780 MlXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH2zT|FKSzVyPUKxMlE{OThizszN MoTOV2FPT0WU
NCI-H345 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTJzLki3O|kh|ryP M2XzWXNCVkeHUh?=
LB771-HNC NWn1[FJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPlVZhQUUN3ME2yNk41QDF|IN88US=> MWPTRW5ITVJ?
RT4 NGLLVnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfiTWM2OD1{Mz6zNlgzKM7:TR?= MVfTRW5ITVJ?
NCI-H82 M3LESGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzHbGxVUUN3ME2yN{42PTJ4IN88US=> M3P2NnNCVkeHUh?=
NCI-H524 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn:wTWM2OD1{ND6zPFEzKM7:TR?= NULiS48zW0GQR1XS
SNU-C1 M3;MSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrMTWM2OD1{ND65NVA2KM7:TR?= MUfTRW5ITVJ?
NCI-SNU-16 M4HCW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTR6LkOxOFIh|ryP NV\ZOGU1W0GQR1XS

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

体内試験 Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]

お薦めの試験操作(参考用のみ)

キナーゼ試験:[3]
+ 展開

Kinase assay:

NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
細胞試験: [1]
+ 展開
  • 細胞株: Human gastric cancer cells NCI-N87
  • 濃度: 1 μM
  • 反応時間: 3 days
  • 実験の流れ: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.
    (参考用のみ)
動物試験:[3]
+ 展開
  • 動物モデル: Female NCr athymic mice bearing WM266.4 human melanoma xenografts
  • 製剤: In DMSO and diluted in sterile saline/Tween 20
  • 投薬量: 50 mg/kg
  • 投与方法: Administered via i.v. or i.p.
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 93 mg/mL (199.76 mM) warming
Ethanol 31 mg/mL (66.58 mM)
Water Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
1% DMSO+30% polyethylene glycol+1% Tween 80
混合させたのち直ちに使用することを推奨します。
30 mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 465.54
化学式

C26H31N3O5

CAS No. 747412-49-3
保管
in solvent
別名 VER-52296

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01922583 Completed Non-small Cell Lung Cancer (NSCLC) National Taiwan University Hospital January 2014 Phase 2
NCT01784640 Active not recruiting Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) January 31 2014 Phase 1
NCT01922583 Completed Non-small Cell Lung Cancer (NSCLC) National Taiwan University Hospital January 2014 Phase 2
NCT01784640 Active not recruiting Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) January 31 2014 Phase 1
NCT01854034 Completed Non Small Cell Lung Cancer Massachusetts General Hospital July 2013 Phase 2
NCT01854034 Completed Non Small Cell Lung Cancer Massachusetts General Hospital July 2013 Phase 2

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

HSP (e.g. HSP90)シグナル伝達経路

HSP (e.g. HSP90) Inhibitors with Unique Features

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Tags: Luminespib (AUY-922, NVP-AUY922)を買う | Luminespib (AUY-922, NVP-AUY922) ic50 | Luminespib (AUY-922, NVP-AUY922)供給者 | Luminespib (AUY-922, NVP-AUY922)を購入する | Luminespib (AUY-922, NVP-AUY922)費用 | Luminespib (AUY-922, NVP-AUY922)生産者 | オーダーLuminespib (AUY-922, NVP-AUY922) | Luminespib (AUY-922, NVP-AUY922)化学構造 | Luminespib (AUY-922, NVP-AUY922)分子量 | Luminespib (AUY-922, NVP-AUY922)代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID