Luminespib (AUY-922, NVP-AUY922)

製品コードS1069 別名:VER-52296

Luminespib (AUY-922, NVP-AUY922)化学構造

分子量(MW):465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

サイズ 価格(税別)  
JPY 53120.00
JPY 26560.00
JPY 44820.00
JPY 78020.00

カスタマーフィードバック(3)

  • U2OS_exo cells were incubated with AUY922 for 20 h at the indicated concentrations before stimulation with TNFα (30 ng/mL) for 30 min and immunostaining to detect NF-κB (p65). DMSO 1%, cells stimulated by TNFα in the absence of AUY922. Representative pictures used to quantify nuclear and cytoplasmic localization of NF-κB.

    Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

    J Biol Chem 2013 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

  • Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922  (ie, induction of HSP72 and depletion of client proteins such as ERBB2, CRAF and CDK4) in BT474 breast cancer cell line. GAPDH was used as loading control.

     

     

    2011 Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

製品安全説明書

HSP (e.g. HSP90)阻害剤の選択性比較

生物活性

製品説明 Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
ターゲット
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
体外試験

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CMK MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXjTWM2OD1yLkCwNFEzPSEQvF2= NEiyeWVUSU6JRWK=
MV-4-11 NVXkSlU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwMECwOVU5KM7:TR?= M3XpXnNCVkeHUh?=
NALM-6 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PsW2lEPTB;MD6wNFA5PDJizszN M4G2U3NCVkeHUh?=
HOS MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXRTWM2OD1yLkCwNVM5KM7:TR?= MXzTRW5ITVJ?
HT-144 NGq1OpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LxXmlEPTB;MD6wNFE2PSEQvF2= NU[yTFd5W0GQR1XS
SW1710 MlnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrSTWM2OD1yLkCwNVg3KM7:TR?= NVy1[nM6W0GQR1XS
TE-8 NH\lN2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnL4TWM2OD1yLkCwNlM4KM7:TR?= MoS2V2FPT0WU
ES1 M4TG[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUH4VXZWUUN3ME2wMlAxOjZ4IN88US=> NHrTeItUSU6JRWK=
CCF-STTG1 Ml7IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTxcIJKSzVyPUCuNFAzQTdizszN NHeyU3dUSU6JRWK=
PSN1 M{XzNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHz[WhKSzVyPUCuNFA{OThizszN M1HxTHNCVkeHUh?=
CAL-51 M1vR[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LpemlEPTB;MD6wNFMzPSEQvF2= NFLqVGxUSU6JRWK=
MCF7 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2WzeGlEPTB;MD6wNFM{PSEQvF2= MYPTRW5ITVJ?
SK-HEP-1 NWS3b|NZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DjcmlEPTB;MD6wNFM{PiEQvF2= NUCzN2FsW0GQR1XS
LCLC-103H Mkm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjGdIdKSzVyPUCuNFA1OyEQvF2= NXH4fVdlW0GQR1XS
HMV-II Mof2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnCcYVKSzVyPUCuNFA1PDlizszN NEHC[5hUSU6JRWK=
MES-SA MorBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknYTWM2OD1yLkCwOFUzKM7:TR?= M{\6XHNCVkeHUh?=
SK-LMS-1 NHjwdVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnoeJhxUUN3ME2wMlAxPDV6IN88US=> MXvTRW5ITVJ?
639-V NUHoRm92T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HO[WlEPTB;MD6wNFQ5PSEQvF2= M3fKcnNCVkeHUh?=
SIG-M5 NGL3W2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPpToxKSzVyPUCuNFA1QDlizszN NUDtSm5xW0GQR1XS
LOUCY M1rjWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1ficWlEPTB;MD6wNFUxPSEQvF2= NWS1XXRGW0GQR1XS
HSC-2 Mnj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PZfGlEPTB;MD6wNFUyQCEQvF2= MWHTRW5ITVJ?
EW-13 NED0RohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPsXmdMUUN3ME2wMlAxPTF6IN88US=> NVHOO3hWW0GQR1XS
RT-112 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\TNFNKSzVyPUCuNFA2OzVizszN MlW3V2FPT0WU
NKM-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV30elBTUUN3ME2wMlAxPTR5IN88US=> NYD6ZopXW0GQR1XS
KYSE-180 NFvwPXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\ZTWM2OD1yLkCwOVg3KM7:TR?= MXTTRW5ITVJ?
SW1783 NI\QRpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMEC1PVEh|ryP MUfTRW5ITVJ?
A431 M4rLbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEO3VlFKSzVyPUCuNFA3ODdizszN MnXXV2FPT0WU
SK-OV-3 NYXROXZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jnSGlEPTB;MD6wNFY{KM7:TR?= MWHTRW5ITVJ?
RPMI-7951 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfyOI9KSzVyPUCuNFA3OzFizszN MkjJV2FPT0WU
Capan-2 MlzKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHrTWM2OD1yLkCwOlM5KM7:TR?= NUHpd|dPW0GQR1XS
HSC-3 NXTNZ5ZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M163XWlEPTB;MD6wNFY1OSEQvF2= NYLlXIt4W0GQR1XS
786-0 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH24b5pKSzVyPUCuNFA3PjNizszN MYrTRW5ITVJ?
Daoy MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\STWM2OD1yLkCwOlk2KM7:TR?= MkfKV2FPT0WU
KGN NHPxd5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HodWlEPTB;MD6wNFcxOyEQvF2= M1n6fXNCVkeHUh?=
EW-16 NF7D[WtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwMEC3OFkh|ryP NYDkSoZJW0GQR1XS
EW-7 M13ncWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlf5TWM2OD1yLkCwO|U1KM7:TR?= MUfTRW5ITVJ?
IGROV-1 NYTEXZk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M171fmlEPTB;MD6wNFgyPCEQvF2= NWn2R4JYW0GQR1XS
8505C M4\5[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTiSZlkUUN3ME2wMlAxQDJzIN88US=> NYHJWZAzW0GQR1XS
RKO MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjhTWM2OD1yLkCwPFI3KM7:TR?= NF3oPHhUSU6JRWK=
GDM-1 NVvMc41OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHvOm92UUN3ME2wMlAxQDRizszN MYHTRW5ITVJ?
IST-MEL1 NVv2eppiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLCTWM2OD1yLkCwPFUzKM7:TR?= MYjTRW5ITVJ?
RPMI-6666 NILzZ2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXy5VWUyUUN3ME2wMlAxQDV{IN88US=> MmTaV2FPT0WU
SNG-M M3fMZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwMEC4OVYh|ryP NETXVmhUSU6JRWK=
KS-1 MnXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\GNGlEPTB;MD6wNFg2QSEQvF2= NIO0NmhUSU6JRWK=
RXF393 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMEC4OkDPxE1? MmD0V2FPT0WU
CAL-12T NXfhTXViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3X6VWlEPTB;MD6wNFkzOiEQvF2= NU\3ZnpQW0GQR1XS
BFTC-905 NGn4[llIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDDTWM2OD1yLkCwPVM5KM7:TR?= MmnXV2FPT0WU
SK-MES-1 NVjjNHlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVy3Now{UUN3ME2wMlAxQTR3IN88US=> M1LTXXNCVkeHUh?=
BB30-HNC M4LDb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7rd4xKSzVyPUCuNFA6PTJizszN MV\TRW5ITVJ?
AN3-CA MmLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXYfotKSzVyPUCuNFExOTdizszN MnjJV2FPT0WU
EFO-27 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMEGwNVch|ryP MUPTRW5ITVJ?
G-401 MkXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\VRYtKSzVyPUCuNFExOjVizszN M{O2[3NCVkeHUh?=
BPH-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXq0[mFmUUN3ME2wMlAyODNizszN MYXTRW5ITVJ?
NCI-H727 NXXvcnBNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXWTWM2OD1yLkCxNFMh|ryP NUPtbZZCW0GQR1XS
SNU-423 MlroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jHTGlEPTB;MD6wNVA2OyEQvF2= MkfHV2FPT0WU
KYSE-270 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vkT2lEPTB;MD6wNVA2QSEQvF2= M1zpbnNCVkeHUh?=
AGS MlewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwMEGwOlEh|ryP MkPCV2FPT0WU
NCI-H2228 NH\KdGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvDV|lKSzVyPUCuNFExPjRizszN NWfJcWdZW0GQR1XS
SW954 Mn3pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwMEGwO|Eh|ryP NHvmRppUSU6JRWK=
769-P NU[4SGRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXJTYp6UUN3ME2wMlAyODd|IN88US=> M2PLb3NCVkeHUh?=
BB49-HNC NFvuRm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPITWM2OD1yLkCxNFc4KM7:TR?= MY\TRW5ITVJ?
IA-LM NEHReJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofSTWM2OD1yLkCxNFg3KM7:TR?= NFi4XFhUSU6JRWK=
NB69 M1\s[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\XTWM2OD1yLkCxNVAzKM7:TR?= NVLMOmJwW0GQR1XS
C8166 NIn4RWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\vTWM2OD1yLkCxNVI6KM7:TR?= M1rxNXNCVkeHUh?=
NCI-H1299 MofOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3BTWM2OD1yLkCxNVU1KM7:TR?= NWWw[VF[W0GQR1XS
YKG-1 NInadGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELFOVZKSzVyPUCuNFEyPiEQvF2= NIX2bmRUSU6JRWK=
PANC-03-27 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYm5[lFYUUN3ME2wMlAyOTZ{IN88US=> MkXJV2FPT0WU
YT M3:zcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwMEGxO|kh|ryP M2ntUHNCVkeHUh?=
CAL-85-1 M{jLemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofuTWM2OD1yLkCxNVkzKM7:TR?= M3nFbHNCVkeHUh?=
GT3TKB NVPOclFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1X6[GlEPTB;MD6wNVIxOiEQvF2= NGC4NnZUSU6JRWK=
BB65-RCC NUTFeJBCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPwfVRKSzVyPUCuNFEzODRizszN Mn\aV2FPT0WU
ES6 NXXtZpN6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUG4fHdqUUN3ME2wMlAyOjZzIN88US=> NYrVUZNiW0GQR1XS
MHH-ES-1 NYDUR2oyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTZXoZKSzVyPUCuNFEzPjNizszN NYnMWGJxW0GQR1XS
QIMR-WIL NXnuSJF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HnNmlEPTB;MD6wNVI3QSEQvF2= NILOW5NUSU6JRWK=
SNU-C2B NWroeHJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\4TWM2OD1yLkCxNlczKM7:TR?= NYrGN3pZW0GQR1XS
OCI-AML2 MkD6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEOxTmxKSzVyPUCuNFEzQDFizszN MWDTRW5ITVJ?
DU-145 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTBwMEGyPUDPxE1? NWTSbWZRW0GQR1XS
SW982 M{nGV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLMNoZKSzVyPUCuNFEzQTNizszN MXfTRW5ITVJ?
MFH-ino NHfGTZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DHOWlEPTB;MD6wNVI6OyEQvF2= NEfscXNUSU6JRWK=
A427 NGCwWVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzrW5BKSzVyPUCuNFEzQTlizszN M1rIU3NCVkeHUh?=
LCLC-97TM1 NFjONnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvZRVdKSzVyPUCuNFE{KM7:TR?= NXnadFdyW0GQR1XS
AM-38 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3X6UGlEPTB;MD6wNVMxOiEQvF2= MUDTRW5ITVJ?
K5 MmW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLLNnhKSzVyPUCuNFE{ODhizszN Ml[0V2FPT0WU
T84 NIjYdG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1iyUWlEPTB;MD6wNVM{OSEQvF2= MWPTRW5ITVJ?
TE-15 NFjpNGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMEGzN|Yh|ryP NF3WXHpUSU6JRWK=
NCI-H460 MmHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVThZoU3UUN3ME2wMlAyOzN4IN88US=> MoKzV2FPT0WU
NTERA-S-cl-D1 NEnW[pVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHxWWVKSzVyPUCuNFE{OzlizszN M4rKTXNCVkeHUh?=
KYSE-450 M3;oVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMEGzOFkh|ryP MmrYV2FPT0WU
H4 MnzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjKfXFCUUN3ME2wMlAyOzZ4IN88US=> MVzTRW5ITVJ?
LC-2-ad MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWmyRndyUUN3ME2wMlAyOzdizszN MY\TRW5ITVJ?
GAMG NW\mZ5g3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTKRlA1UUN3ME2wMlAyOzdzIN88US=> M33RT3NCVkeHUh?=
TK10 M2\DS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFruOWFKSzVyPUCuNFE{QDJizszN MWDTRW5ITVJ?
NCI-H2122 NELoOVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fmcGlEPTB;MD6wNVM5PCEQvF2= NVTa[JkxW0GQR1XS
KM12 M3:xfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHyTWM2OD1yLkCxN|k6KM7:TR?= NYe1WIVDW0GQR1XS
CAL-39 NUG2doZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkO0TWM2OD1yLkCxOFIh|ryP MmTzV2FPT0WU
RPMI-2650 MmjUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzvTWM2OD1yLkCxOFMzKM7:TR?= MljSV2FPT0WU
KYSE-510 NVnaTWVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHLTWM2OD1yLkCxOFQzKM7:TR?= NH;YTlJUSU6JRWK=
KALS-1 MmDjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1L5R2lEPTB;MD6wNVQ3PiEQvF2= NF7K[YdUSU6JRWK=
NCI-H1648 NUL3SG9vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\KTWM2OD1yLkCxOFk6KM7:TR?= M3[1cXNCVkeHUh?=
ES4 Mlu1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{T3N2lEPTB;MD6wNVUxOiEQvF2= M4TUSXNCVkeHUh?=
C-33-A MnPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjtbHNKSzVyPUCuNFE2ODlizszN NX;PUGNHW0GQR1XS
MIA-PaCa-2 NGn6VnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDNcmVWUUN3ME2wMlAyPTB7IN88US=> Mo\oV2FPT0WU
Becker NFTpOGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3G4WGlEPTB;MD6wNVUyPCEQvF2= MXnTRW5ITVJ?
HOP-62 NWfId4VsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljtTWM2OD1yLkCxOVQzKM7:TR?= M2DIUHNCVkeHUh?=
TE-1 M1vwUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMEG1PFEh|ryP NWTo[5lCW0GQR1XS
KYSE-410 MlvUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTHblVpUUN3ME2wMlAyPTh4IN88US=> MVvTRW5ITVJ?
NOS-1 NX\DUpdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPJdnZZUUN3ME2wMlAyPTl|IN88US=> MYPTRW5ITVJ?
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RS4-11 NYTyW3QxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3WNIVKSzVyPUCuNFM{QDNizszN MmnMV2FPT0WU
JiyoyeP-2003 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLaTWM2OD1yLkCzN|g5KM7:TR?= NFKyR|FUSU6JRWK=
BL-70 M2r6bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMEOzPFkh|ryP MnPDV2FPT0WU
OS-RC-2 NXPSWItCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1Xwe2lEPTB;MD6wN|M6PiEQvF2= NXzhOIRCW0GQR1XS
SF268 NV;sOnNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TXdWlEPTB;MD6wN|QxOSEQvF2= NVLiVGp4W0GQR1XS
BV-173 M3iy[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml[0TWM2OD1yLkCzOFI3KM7:TR?= M4Cy[XNCVkeHUh?=
DMS-273 NVnabGVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzYTWM2OD1yLkCzOFc6KM7:TR?= NXG4PG5KW0GQR1XS
22RV1 NWnyS2ZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmiwTWM2OD1yLkCzOVA4KM7:TR?= Mkm1V2FPT0WU
ES8 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFmwfYxKSzVyPUCuNFM2OzhizszN MW\TRW5ITVJ?
KYSE-150 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vUVmlEPTB;MD6wN|YxQCEQvF2= NILISmNUSU6JRWK=
HCC1569 NInWfnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwMEO2NFgh|ryP MXXTRW5ITVJ?
NB5 NVT4THFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGf6OopKSzVyPUCuNFM3OTNizszN M3PEZXNCVkeHUh?=
G-402 Mm\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HoPWlEPTB;MD6wN|YyPCEQvF2= NHnMT4lUSU6JRWK=
NCI-H1693 M{jyfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\qO5pKSzVyPUCuNFM3OTdizszN NYTiNG5oW0GQR1XS
LB2241-RCC MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzaTWM2OD1yLkCzOlQzKM7:TR?= NV;QXY1CW0GQR1XS
KP-4 MmXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zPPGlEPTB;MD6wN|Y3OyEQvF2= MXLTRW5ITVJ?
ML-2 M1njXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfsWnpKSzVyPUCuNFM3PzFizszN MmLRV2FPT0WU
KU812 NG\xOGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlL3TWM2OD1yLkCzOlg1KM7:TR?= MVTTRW5ITVJ?
LS-411N NUTsTotNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\vTWM2OD1yLkCzO|MyKM7:TR?= NX3DdmN7W0GQR1XS
OAW-42 NUfDPWxiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jmPWlEPTB;MD6wN|c1PyEQvF2= NYrhWldXW0GQR1XS
HCC38 MkLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPrcVRKSzVyPUCuNFM4PzFizszN MknFV2FPT0WU
Ca-Ski NXzGNZhyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XpZ2lEPTB;MD6wN|c5PCEQvF2= M{nWNXNCVkeHUh?=
Calu-3 MnO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zNOGlEPTB;MD6wN|c5QSEQvF2= MWLTRW5ITVJ?
KYSE-70 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LXbmlEPTB;MD6wN|gyOiEQvF2= M2jheXNCVkeHUh?=
D-392MG M1zVTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mor2TWM2OD1yLkCzPFQzKM7:TR?= Mlj6V2FPT0WU
OVCAR-4 M3G2Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fMRWlEPTB;MD6wN|g2QCEQvF2= NYHrNlRLW0GQR1XS
Detroit562 NWPVeI9DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwMEO4O|Ih|ryP M4W5WXNCVkeHUh?=
HEL MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwMEO4PVEh|ryP NV\3OHdoW0GQR1XS
MONO-MAC-6 MluwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYm2bIlWUUN3ME2wMlA{QDl|IN88US=> Mk[xV2FPT0WU
LoVo NFfrPWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMEO5N|Mh|ryP M{W5SXNCVkeHUh?=
U-2-OS MnfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMEO5N|Uh|ryP NX74Z5llW0GQR1XS
A172 M2S0VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\WWVdUUUN3ME2wMlA{QTVizszN M1TPeXNCVkeHUh?=
OCUB-M M3vvcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXWflVKSzVyPUCuNFM6PjFizszN Mnr3V2FPT0WU
SW48 MofzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnPSXYxUUN3ME2wMlA1ODNzIN88US=> NH3mfJlUSU6JRWK=
HC-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{D4UmlEPTB;MD6wOFA3QSEQvF2= NG[3VYhUSU6JRWK=
KOSC-2 NW\JWHFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\aSHZKSzVyPUCuNFQyOSEQvF2= MnvVV2FPT0WU
HDLM-2 NVLqeJdPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HDNmlEPTB;MD6wOFEyPCEQvF2= Mlf5V2FPT0WU
CTV-1 NUW3Zok2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;UOG1YUUN3ME2wMlA1OTF4IN88US=> NFW2b2hUSU6JRWK=
SH-4 MnToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;nNnVKSzVyPUCuNFQyPDFizszN MWLTRW5ITVJ?
SW756 MlnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLYOotKSzVyPUCuNFQyPTdizszN NVTSUoZIW0GQR1XS
GCT NGDKUopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFX3botKSzVyPUCuNFQyPjFizszN MYjTRW5ITVJ?
CHL-1 NIX4cWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmCwTWM2OD1yLkC0NVY6KM7:TR?= MWDTRW5ITVJ?
LAMA-84 NX;FR45CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1z2d2lEPTB;MD6wOFE4OSEQvF2= NFPLd3NUSU6JRWK=
LS-1034 M2jyeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3z4U2lEPTB;MD6wOFE6OSEQvF2= NV;NNHVUW0GQR1XS
NCI-H358 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYmzb|l6UUN3ME2wMlA1OjF{IN88US=> MXHTRW5ITVJ?
NB13 M{LRXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7DTWM2OD1yLkC0NlI4KM7:TR?= Ml\rV2FPT0WU
TE-9 NV;WbXBFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHIbGJ{UUN3ME2wMlA1OjN5IN88US=> MlHNV2FPT0WU
OE33 M{DRU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\2bIdMUUN3ME2wMlA1OjRzIN88US=> MmPXV2FPT0WU
CAL-120 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwMESyOFEh|ryP NFrjeYZUSU6JRWK=
DJM-1 M1f2eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;rb3E2UUN3ME2wMlA1Ojd{IN88US=> MUTTRW5ITVJ?
SK-MEL-24 MmHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLLTWM2OD1yLkC0Nlg{KM7:TR?= NEDzVZhUSU6JRWK=
VA-ES-BJ NUezRYNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrIUYJuUUN3ME2wMlA1Ojl{IN88US=> NUjiVphwW0GQR1XS
MMAC-SF MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwMESyPVch|ryP NHTkO2tUSU6JRWK=
MZ7-mel Mk\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzvTWM2OD1yLkC0N|Mh|ryP M37NenNCVkeHUh?=
BxPC-3 M3u0UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfXfmY4UUN3ME2wMlA1OzRzIN88US=> NH;WSohUSU6JRWK=
HT-29 MnPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrSWZJvUUN3ME2wMlA1OzV5IN88US=> MY\TRW5ITVJ?
SK-MEL-30 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PM[mlEPTB;MD6wOFM3OiEQvF2= MYfTRW5ITVJ?
CAL-33 M33PWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHXTWM2OD1yLkC0N|c2KM7:TR?= MnnGV2FPT0WU
COLO-680N MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zHSmlEPTB;MD6wOFQxPyEQvF2= M1PzbnNCVkeHUh?=
NH-12 NFK1bmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjr[3RKSzVyPUCuNFQ1PCEQvF2= M3XFbXNCVkeHUh?=
HCC1937 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXDUZJOUUN3ME2wMlA1PDV4IN88US=> MmTVV2FPT0WU
IMR-5 NGD4cGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHJTWM2OD1yLkC0OFkh|ryP M1joWXNCVkeHUh?=
MC-CAR NWXMdox4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPhSnhKSzVyPUCuNFQ2PjlizszN MlXFV2FPT0WU
NCI-H747 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\UUnhKSzVyPUCuNFQ2PyEQvF2= M1fyeXNCVkeHUh?=
NCI-H1792 NVzBSFY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrid5FKUUN3ME2wMlA1PThzIN88US=> NFjuSllUSU6JRWK=
SW13 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3xV4VKSzVyPUCuNFQ2QSEQvF2= MVnTRW5ITVJ?
MLMA Ml7nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTXXWhsUUN3ME2wMlA1PjB7IN88US=> MnrqV2FPT0WU
U251 NHfRenZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;VTWM2OD1yLkC0O|Y{KM7:TR?= MVTTRW5ITVJ?
U031 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1v2[2lEPTB;MD6wOFc4OSEQvF2= NX32XIkzW0GQR1XS
ME-180 NHT2cpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DuUWlEPTB;MD6wOFc5OiEQvF2= NUCxbph1W0GQR1XS
SK-MEL-3 M1nDemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwMES4NFIh|ryP NV\tWmNlW0GQR1XS
MOLT-4 NIfBXYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3v5bWlEPTB;MD6wOFgxOyEQvF2= M4XmSHNCVkeHUh?=
PF-382 NGTLWodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmL2TWM2OD1yLkC0PFI3KM7:TR?= MWrTRW5ITVJ?
NUGC-3 M1XxR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3znPGlEPTB;MD6wOFgzPyEQvF2= MknMV2FPT0WU
NCI-H1417 NXryWlU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwMES4PUDPxE1? NGDEbGRUSU6JRWK=
COLO-205 NWWwbJc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvPTWM2OD1yLkC0PVE6KM7:TR?= NF;RbpFUSU6JRWK=
TE-441-T NES1UGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1z5OWlEPTB;MD6wOFk{KM7:TR?= M4TUZnNCVkeHUh?=
MKN1 NXLmdIZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwMES5N{DPxE1? Mn\4V2FPT0WU
UM-UC-3 M2nJ[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrXe49KSzVyPUCuNFQ6PSEQvF2= NVKxSmgxW0GQR1XS
SF126 MkDyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\ndolKSzVyPUCuNFUxOSEQvF2= NWP3XmJrW0GQR1XS
LB1047-RCC NYPYR3h6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwMEWwN|Eh|ryP NUjjXGRVW0GQR1XS
A253 MnLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwMEWwOVIh|ryP MmDxV2FPT0WU
NCI-H1963 M1\icWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwMEWxO|Yh|ryP NVKzflJ2W0GQR1XS
VM-CUB-1 NIKxVpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMEWzNVEh|ryP MmHYV2FPT0WU
T-24 NHLicXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHF[IlKSzVyPUCuNFU{QDRizszN MofqV2FPT0WU
K-562 M3jMR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMEWzPFch|ryP MVHTRW5ITVJ?
ARH-77 M1;rbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\1fWlEPTB;MD6wOVM6PSEQvF2= M4rQ[HNCVkeHUh?=
CA46 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjKTWM2OD1yLkC1OFMh|ryP M3\LT3NCVkeHUh?=
HCC70 M2m4UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoH2TWM2OD1yLkC1OFUzKM7:TR?= NH3VflFUSU6JRWK=
ST486 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPYTWM2OD1yLkC1OVI2KM7:TR?= NHn0SY5USU6JRWK=
COLO-741 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DhUGlEPTB;MD6wOVU{OSEQvF2= MVfTRW5ITVJ?
SK-PN-DW NF3Ec3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rwOWlEPTB;MD6wOVU5QCEQvF2= M3rwXHNCVkeHUh?=
BL-41 NHvGSVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXVTWM2OD1yLkC1OVk3KM7:TR?= NUHWWZZpW0GQR1XS
D-263MG NIf2c|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmL6TWM2OD1yLkC1Olg{KM7:TR?= M3zLUHNCVkeHUh?=
KE-37 Ml;kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwMEW2PFMh|ryP NV3KZVd6W0GQR1XS
LU-134-A MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGW4VZlKSzVyPUCuNFU4OTVizszN MWnTRW5ITVJ?
HCC2157 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\uR2dKSzVyPUCuNFU4OzNizszN M2\q[nNCVkeHUh?=
GAK NVrwTolMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LkdmlEPTB;MD6wOVc{PCEQvF2= NYXPNYlJW0GQR1XS
IST-SL2 MoD6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvzTWM2OD1yLkC1O|Q{KM7:TR?= MUnTRW5ITVJ?
KMOE-2 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XZSmlEPTB;MD6wOVc1QSEQvF2= NV\nTYdJW0GQR1XS
SW1573 NEnBV2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7qTWM2OD1yLkC1PFAzKM7:TR?= NGDGWmRUSU6JRWK=
SCC-9 NF7ZVnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHjcmlKSzVyPUCuNFU5PyEQvF2= M3;5fHNCVkeHUh?=
MDA-MB-361 M3HUbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfEXYJKSzVyPUCuNFU5PzJizszN NFnFd3VUSU6JRWK=
BHT-101 NUnUPGJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYX5UYt4UUN3ME2wMlA2QDd4IN88US=> NHflT21USU6JRWK=
NCI-H1770 M1uwcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMEW4O|kh|ryP NGPZUHRUSU6JRWK=
UACC-893 MljTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwMEW4PVYh|ryP NF30ZlFUSU6JRWK=
NCI-H226 Mnj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHl[Y5KSzVyPUCuNFU6QDhizszN NUHMepJnW0GQR1XS
HLE NGPEb|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwME[wPFIh|ryP MXvTRW5ITVJ?
NCI-H1703 MmXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHf5cIVKSzVyPUCuNFYyPzhizszN MWLTRW5ITVJ?
KURAMOCHI NXPmbI9FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;GTWM2OD1yLkC2NVg6KM7:TR?= MlvuV2FPT0WU
RH-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEK3TGJKSzVyPUCuNFYzOyEQvF2= MVLTRW5ITVJ?
DSH1 M1HYbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vXW2lEPTB;MD6wOlI4KM7:TR?= Ml\1V2FPT0WU
CAMA-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\lWplKSzVyPUCuNFY{ODNizszN NEC3TZNUSU6JRWK=
NCI-H1437 M1vJ[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHsTWM2OD1yLkC2N|I5KM7:TR?= NXLvT25RW0GQR1XS
HuP-T4 NE\qc|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDENZJ1UUN3ME2wMlA3PTh4IN88US=> MWLTRW5ITVJ?
HCT-15 NUO3eJVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFX3NWNKSzVyPUCuNFY2QTdizszN NIq2NHFUSU6JRWK=
NCCIT NXvKZ2E4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLuU|JEUUN3ME2wMlA3PjB2IN88US=> M2njOnNCVkeHUh?=
BOKU NXPWfppDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTjTWM2OD1yLkC2Olc1KM7:TR?= MlXlV2FPT0WU
FADU NIXCV25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XFe2lEPTB;MD6wOlc1PSEQvF2= MUXTRW5ITVJ?
SUP-T1 MofOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTBwME[3OkDPxE1? MX\TRW5ITVJ?
L-363 M4f5Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\YdWlEPTB;MD6wOlkxOSEQvF2= M1vzTXNCVkeHUh?=
KNS-81-FD MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjsZ2hzUUN3ME2wMlA3QTF6IN88US=> M3;qe3NCVkeHUh?=
SU-DHL-1 NFvLO3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwME[5NkDPxE1? MWLTRW5ITVJ?
HuH-7 M{P1WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfUR4RwUUN3ME2wMlA4ODN3IN88US=> NGTUN2ZUSU6JRWK=
BT-474 NHT1RWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwMEewOlEh|ryP NF7Hd5ZUSU6JRWK=
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TALL-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHiSnpMUUN3ME2xMlI2OTZ3IN88US=> NYXOTYx3W0GQR1XS
RO82-W-1 MlHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\OTWM2OD1zLkOzN|M6KM7:TR?= MofXV2FPT0WU
NCI-H1581 NFLPW2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUexOI02UUN3ME2xMlM2Pjh5IN88US=> NETuR|dUSU6JRWK=
NCI-H748 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTFwM{W3N|gh|ryP NUTleWw3W0GQR1XS
HCC1187 NEHCdGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XJeWlEPTB;MT61OVUzOiEQvF2= M3Pp[XNCVkeHUh?=
EoL-1-cell NVTpS|BlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTFwNUi4PFkh|ryP MVzTRW5ITVJ?
HuO-3N1 M130d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTPTWM2OD1zLkizOFEzKM7:TR?= M2\vN3NCVkeHUh?=
NCI-H1793 M4rLbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjHZXdKSzVyPUGuPFc2QTNizszN M4W4fXNCVkeHUh?=
Caov-3 MnnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3KySGlEPTB;Mj6wNFYzPSEQvF2= NICxSYRUSU6JRWK=
JAR MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTJwMEe5NkDPxE1? NF3ubFVUSU6JRWK=
SK-MEL-28 NHXmZVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3ThZ2lEPTB;Mj6xPFA6QCEQvF2= M3iyW3NCVkeHUh?=
EM-2 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTJwMkCyPVMh|ryP MkGyV2FPT0WU
Mewo M13FT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknyTWM2OD1{LkKyNlY2KM7:TR?= NVLQSIZ5W0GQR1XS
NCI-H720 NFv0V29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXDTWM2OD1{LkK2OVg2KM7:TR?= MYDTRW5ITVJ?
CAL-54 NIrSZY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXPTWM2OD1{LkK2O|k2KM7:TR?= MV\TRW5ITVJ?
MC116 MoTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7pNYpKSzVyPUKuN|Y{QTdizszN MYDTRW5ITVJ?
DG-75 NWnyPHhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDLTWM2OD1{LkS4OVc3KM7:TR?= MVvTRW5ITVJ?
HCC1143 M{e1UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7iTWM2OD1{LkWwOlU5KM7:TR?= NHPDc2FUSU6JRWK=
FTC-133 MnHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvkTWM2OD1{LkWzOlg6KM7:TR?= MWDTRW5ITVJ?
AsPC-1 NIHrOppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETyWWtKSzVyPUKuOVM6OjlizszN NYLsfG9WW0GQR1XS
NCI-H889 NXrxfY84T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDaTWM2OD1{LkW2O|A3KM7:TR?= Ml:2V2FPT0WU
HT55 M{nPV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTJwNkKwNVkh|ryP NGP4UZZUSU6JRWK=
UMC-11 NWXBOHhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fPWmlEPTB;Mj63PFcyPSEQvF2= NVi5R2FiW0GQR1XS
P12-ICHIKAWA MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIX5WllKSzVyPUKuPFIxPDZizszN M{W2SHNCVkeHUh?=
HCC1395 M4LvTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHOU29KSzVyPUKuPVg3ODJizszN M1f6TnNCVkeHUh?=
D-283MED M3Lmdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTNwMUi5N|ch|ryP M4L3bnNCVkeHUh?=
COLO-800 NEXEbmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml[wTWM2OD1|LkOzPFk4KM7:TR?= M{X2WnNCVkeHUh?=
MFM-223 NXj3XlVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rWemlEPTB;Mz6zOlA6PyEQvF2= NVTseIg2W0GQR1XS
TE-5 M4KyV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTRwNU[xOFch|ryP NYntNI9wW0GQR1XS
NCI-H209 MlTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTRwN{i1O|Ih|ryP Mn3jV2FPT0WU
SiHa NGXW[4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\BbXFDUUN3ME20Mlk2OjB|IN88US=> M3T0dHNCVkeHUh?=
NCI-H1395 NHPzUFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7ZXYFIUUN3ME21MlExPjN|IN88US=> NGHueFZUSU6JRWK=
A498 M3\pUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHUcodKSzVyPUWuNlEzPTFizszN NISyTWdUSU6JRWK=
ES5 M1v6VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTVwNkGxO|gh|ryP MVPTRW5ITVJ?
MDA-MB-157 M{TLRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\nTmlEPTB;NT62OlQ1OyEQvF2= Mk[yV2FPT0WU
NCI-H1623 Mk[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jSdGlEPTB;NT64N|U2PiEQvF2= MXXTRW5ITVJ?
RPMI-8866 NIjwfZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4f3WmlEPTB;NT64OFc6OiEQvF2= NX\wR|JyW0GQR1XS
LC-1F MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDPTWM2OD14LkC5NlkyKM7:TR?= NUHSVHFRW0GQR1XS
TCCSUP MnToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HmZmlEPTB;Nj62NFM1QSEQvF2= NEHwR2tUSU6JRWK=
TT M1zY[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfG[3ZKSzVyPUiuN|MxODlizszN MmDoV2FPT0WU
NCI-H1838 Mkf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\BNmlEPTB;OD61NVc{OSEQvF2= NHu3OVRUSU6JRWK=
NCI-H322M M4SzR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGj1fnVKSzVyPUmuNVYzQDFizszN MWrTRW5ITVJ?
NCI-H187 M{L4dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlL3TWM2OD17LkWxPFM2KM7:TR?= M2HxNHNCVkeHUh?=
SBC-1 M{jFVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fmNmlEPTB;OT65N|Y2PiEQvF2= MWLTRW5ITVJ?
SCC-3 NV7RZlVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\HUIRKSzVyPUGwMlU3PzlizszN MX\TRW5ITVJ?
SW948 NFnWUnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHVbHBqUUN3ME2xNE44PTFzIN88US=> M3HuPHNCVkeHUh?=
CPC-N NVHke3VkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGe2OVZKSzVyPUGxMlAxPyEQvF2= MVfTRW5ITVJ?
TGBC24TKB NYXlSlJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXHTWM2OD1zMz61Nlkh|ryP NUDtOo5QW0GQR1XS
NCI-H2452 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjwcXNKSzVyPUG0Mlc{KM7:TR?= Mn7GV2FPT0WU
Hs-578-T M3;XUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HUUmlEPTB;MUiuOVc2QSEQvF2= NWLFPZo{W0GQR1XS
DV-90 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfidmFKSzVyPUG4Mlk6PDVizszN NWjURYxwW0GQR1XS
NCI-H1563 NFfzfmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTF7Lke4PFgh|ryP NFnkOHVUSU6JRWK=
SW780 MoDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTJzLkGzNVgh|ryP NGTYcJFUSU6JRWK=
NCI-H345 M{LMUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfqR5NKSzVyPUKxMlg4PzlizszN NVfhXXcyW0GQR1XS
LB771-HNC NVnId5oyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTJ{LkS4NVMh|ryP MkKxV2FPT0WU
RT4 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTJ|LkOyPFIh|ryP NYrYRXZ6W0GQR1XS
NCI-H82 M3nUSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTpZppjUUN3ME2yN{42PTJ4IN88US=> M1vCO3NCVkeHUh?=
NCI-H524 M1;y[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTJ2LkO4NVIh|ryP NGWzd2FUSU6JRWK=
SNU-C1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXj3b|l7UUN3ME2yOE46OTB3IN88US=> MXHTRW5ITVJ?
NCI-SNU-16 NGnuXZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rFUmlEPTB;NEiuN|E1OiEQvF2= NWq5foVXW0GQR1XS

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

体内試験 Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]

お薦めの試験操作(参考用のみ)

キナーゼ試験:[3]
+ 展開

Kinase assay:

NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
細胞試験: [1]
+ 展開
  • 細胞株: Human gastric cancer cells NCI-N87
  • 濃度: 1 μM
  • 反応時間: 3 days
  • 実験の流れ: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.
    (参考用のみ)
動物試験:[3]
+ 展開
  • 動物モデル: Female NCr athymic mice bearing WM266.4 human melanoma xenografts
  • 製剤: In DMSO and diluted in sterile saline/Tween 20
  • 投薬量: 50 mg/kg
  • 投与方法: Administered via i.v. or i.p.
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 93 mg/mL (199.76 mM) warming
Ethanol 31 mg/mL (66.58 mM)
Water Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
1% DMSO+30% polyethylene glycol+1% Tween 80
混合させたのち直ちに使用することを推奨します。
30 mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 465.54
化学式

C26H31N3O5

CAS No. 747412-49-3
保管
in solvent
別名 VER-52296

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01922583 Completed Non-small Cell Lung Cancer (NSCLC) National Taiwan University Hospital January 2014 Phase 2
NCT01784640 Active not recruiting Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) January 31 2014 Phase 1
NCT01854034 Completed Non Small Cell Lung Cancer Massachusetts General Hospital July 2013 Phase 2
NCT01772797 Completed Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis June 2013 Phase 1
NCT01752400 Completed Non Small Cell Lung Cancer Massachusetts General Hospital January 2013 Phase 2
NCT01613950 Completed Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein Novartis Pharmaceuticals|Novartis December 2012 Phase 1

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

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Tags: Luminespib (AUY-922, NVP-AUY922)を買う | Luminespib (AUY-922, NVP-AUY922) ic50 | Luminespib (AUY-922, NVP-AUY922)供給者 | Luminespib (AUY-922, NVP-AUY922)を購入する | Luminespib (AUY-922, NVP-AUY922)費用 | Luminespib (AUY-922, NVP-AUY922)生産者 | オーダーLuminespib (AUY-922, NVP-AUY922) | Luminespib (AUY-922, NVP-AUY922)化学構造 | Luminespib (AUY-922, NVP-AUY922)分子量 | Luminespib (AUY-922, NVP-AUY922)代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID