Sorafenib (BAY 43-9006)

For research use only. Not for use in humans.

製品コードS7397 別名:NSC-724772

Sorafenib (BAY 43-9006)化学構造

CAS No. 284461-73-0

Sorafenib (BAY 43-9006, NSC-724772) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.

サイズ 価格(税別)  
JPY 26400
JPY 46800
JPY 113200
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バルク問合せ

文献中Selleckの製品使用例(397)

製品安全説明書

Raf阻害剤の選択性比較

生物活性

製品説明 Sorafenib (BAY 43-9006, NSC-724772) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.
ターゲット
Raf-1 [1]
(Cell-free assay)
mVEGFR2(Flk1) [1]
(Cell-free assay)
mVEGFR3 [1]
(Cell-free assay)
B-Raf [1]
(Cell-free assay)
B-Raf (V599E) [1]
(Cell-free assay)
6 nM 15 nM 20 nM 22 nM 38 nM
体外試験

Sorafenib inhibits both wild-type and V599E mutant B-Raf activity with IC50 of 22 nM and 38 nM, respectively. Sorafenib also potently inhibits mVEGFR2 (Flk-1), mVEGFR3, mPDGFRβ, Flt3, and c-Kit with IC50 of 15 nM, 20 nM, 57 nM, 58 nM, and 68 nM, respectively. Sorafenib weakly inhibits FGFR-1 with IC50 of 580 nM. Sorafenib tosylate is not active against ERK-1, MEK-1, EGFR, HER-2, IGFR-1, c-Met, PKB, PKA, cdk1/cyclinB, PKCα, PKCγ, and pim-1. Sorafenib markedly inhibits VEGFR2 phosphorylation in NIH 3T3 cells with IC50 of 30 nM, and Flt-3 phosphorylation in HEK-293 cells with IC50 of 20 nM. Sorafenib potently blocks MEK 1/2 and ERK 1/2 phosphorylation in most cell lines but not in A549 or H460 cells, while having no effect on inhibition of the PKB pathway. Sorafenib inhibits the proliferation of HAoSMC and MDA-MB-231 cells with IC50 of 0.28 μM and 2.6 μM, respectively. [1] In addition to inhibition of the RAF/MEK/ERK signaling pathway, Sorafenib significantly inhibits the phosphorylation of eIF4E and down-regulates Mcl-1 levels in hepatocellular carcinoma (HCC) cells in a MEK/ERK-independent manner. Sorafenib inhibits the proliferation of PLC/PRF/5 and HepG2 cells with IC50 of 6.3 μM and 4.5 μM, respectively, and leads to the significant induction of apoptosis. [2]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MV-4-11 NGnufJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3LTHRlUUN3ME2wMlAxODByM{CzJO69VQ>? MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
MONO-MAC-6 NEnLd|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TEcGlEPTB;MD6wNFQyQCEQvF2= NETZdpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
ALL-PO M2rwOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fPN2lEPTB;MD6wN|E5PCEQvF2= NIHxTFE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
NKM-1 M{TZXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzvTWM2OD1yLkC3OFE3KM7:TR?= M364[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
CGTH-W-1 NWTlWXdtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLHTWM2OD1yLkK1NFIzKM7:TR?= MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
BB65-RCC NVHFdI9wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13rUGlEPTB;MD60O|A4OyEQvF2= MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
NOS-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwNU[zOkDPxE1? NVLLcFlCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
SH-4 NY\wV|Q6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vDTWlEPTB;MD62OVYyOyEQvF2= NG\aUWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
HOP-62 NF3VSVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfBTWM2OD1yLki1NFg5KM7:TR?= NYPoWnVXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
HCC2998 NVfH[XpCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmf1TWM2OD1yLki4PFE5KM7:TR?= M4jYfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
GDM-1 NIr5doRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwOUC2PVgh|ryP Ml2xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVM{Pi9pPmPBUmdGWjxxYU6=
KM12 NVjMUWlOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETXRm9KSzVyPUGuNFIxQThizszN NGXDbFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
LB2518-MEL NFz3OJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfiZ5VKSzVyPUGuNlA5ODlizszN M3XtVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
NCI-H1436 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXadVRKSzVyPUGuNlE3PzhizszN MoewQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVM{Pi9pPmPBUmdGWjxxYU6=
EM-2 NX;3TnlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTFwM{W1O|gh|ryP NVywSGhORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
LAMA-84 NGKzWFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\GXo1KSzVyPUGuN|c3PDhizszN M1nkSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
KG-1 NIi1VnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfQTWM2OD1zLkS3PVM2KM7:TR?= MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
A388 MonTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLNTWM2OD1zLkW5NVY2KM7:TR?= M3\TTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
no-10 NGDIUm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXBZY45UUN3ME2xMlYyPzJ4IN88US=> NWHTR2xrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
SF126 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfhOZlkUUN3ME2xMlY{QDF{IN88US=> MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
MEG-01 M4DDRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnM[m1KSzVyPUGuPFA6QCEQvF2= NYPPUZd2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
A3-KAW M2jpdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrxPGZDUUN3ME2xMlg5PDJizszN NYi3dVZLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
D-247MG MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUH1RohOUUN3ME2yMlE1PDhizszN NUXwOFY4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
OVCAR-4 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7idnNKSzVyPUKuNlE{QTNizszN MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
NCI-SNU-1 NUXTS5NRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTJwM{G2NkDPxE1? NEDyXnc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
NCI-H2171 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTJwM{m3OlQh|ryP MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
SIG-M5 Mn3lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDpTWM2OD1{LkSyNlQzKM7:TR?= Mk\5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVM{Pi9pPmPBUmdGWjxxYU6=
BE-13 NUW3fnlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DaVmlEPTB;Mj62PVYxQSEQvF2= M3LC[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
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L-540 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFW0PYhKSzVyPUKuO|U4QDlizszN MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
KMOE-2 NGGwN3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnKxTWM2OD1{LkixN|Uh|ryP MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
MFH-ino M3LtdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlT2TWM2OD1{LkmyNVg2KM7:TR?= NGLKfGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
HL-60 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\QTWM2OD1|LkC2Nlk6KM7:TR?= M{PSflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
HCC2218 MkPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rpdmlEPTB;Mz6xNlAxOyEQvF2= MkT1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVM{Pi9pPmPBUmdGWjxxYU6=
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MZ1-PC MnL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTNwNEe1NFkh|ryP M4\QbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
MRK-nu-1 NWrKW4VzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nifWlEPTB;Mz62NVQ3QCEQvF2= NUDhTVlLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
MZ7-mel Mk\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknWTWM2OD1|Lk[2NFk6KM7:TR?= NIXsV|E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
BC-1 MlnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfHV3lyUUN3ME2zMlc1ODJizszN NYC0fHNFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
ST486 NGe3[FlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3OTWM2OD1|LkizOlc{KM7:TR?= NEnL[2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
KS-1 NG[5OnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrKTWM2OD1|Lki4NVk5KM7:TR?= NXL0cJJiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
SK-NEP-1 Mnn0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zxNmlEPTB;ND6xOlgyPSEQvF2= M3;pOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
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SF539 Mn\iS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M37TUWdKPTBiPTCxMlU5KM7:TR?= NGi3NlI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
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HL-60(TB) NVvPWGljS3m2b4TvfIlkcXS7IHHzd4F6 NIDrN2VIUTVyIE2gNU42QCEQvF2= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
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SF539 NXf5SGNLS3m2b4TvfIlkcXS7IHHzd4F6 MonKS2k2OCB;IEGuOVgh|ryP NFrVWY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
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MDA-MB-435 M{\PbGN6fG:2b4jpZ4l1gSCjc4PhfS=> MYnHTVUxKD1iMT61PEDPxE1? Ml3BQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
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UACC62 NVvDOZB6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NILQd3RIUTVyIE2gNU42QCEQvF2= NYX1coxJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
SK-MEL-5 M4TDR2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MnzWS2k2OCB;IEGuOVgh|ryP NXTiUpJyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
KM12 MXrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NGjLfHpIUTVyIE2gNU42QCEQvF2= NGS5XnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
MDA-MB-435 M4fISGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M2THeGdKPTBiPTCxMlU5KM7:TR?= NVrBXGM4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
SF539 MXfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NGXvPYFIUTVyIE2gNU42QCEQvF2= M3HNSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
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HCT116 MkLRRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NH;rNWtIUTVyIE2gNU42QCEQvF2= NUWyZlJDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
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HL-60(TB) M3;RRWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MkjxS2k2OCB;IEGuOVgh|ryP NFTvNII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
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MCF7 NIDROWRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M3jMSWlEPTBiPTCxMlg5KM7:TR?= NWjl[VZmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2N|cyOjNpPkK1OlM4OTJ|PD;hQi=>
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MDA-MB-231 MXHDfZRwfG:6aXPpeJkh[XO|YYm= M4fTVGlEPTBiPTCyJO69VQ>? NVHTWGp5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0OVQxOTdpPkKzOFU1ODF5PD;hQi=>
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U937 MWDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NWPSV5VbT0l3MDC9JFIvPzRizszN MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjNzOEC2O{c,OjZ|MUiwOlc9N2F-
U937 NV\SWVJpS3m2b4TvfIlkcXS7IHHzd4F6 M1vROGdKPTBiPTCyMlc1KM7:TR?= MnPIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6N{ixPVMoRjJ2OEe4NVk{RC:jPh?=
MCF7 MkS5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NF\EZmhKSzVyIE2gNk44QCEQvF2= NW\zXW5YRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxNFIyPzVpPkK5NVAzOTd3PD;hQi=>
MDA-MB-231 MV;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NYL1WW1lUUN3MDC9JFIvQCEQvF2= NVzEToJ7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmyNFI1ODNpPkK5NlAzPDB|PD;hQi=>
HepG2 M1vMOGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MlvhTWM2OCB;IEKuPFQh|ryP NEnUe3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK0NlU2Oyd-MkiyOFI2PTN:L3G+
U937 NXm5bW82T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWrybZJGT0l3MDC9JFIvQDVizszN M3zoNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MEG0O|U2Lz5{MkCxOFc2PTxxYU6=
A549 MYnDfZRwfG:6aXPpeJkh[XO|YYm= NGG1[pNKSzVyIE2gNk46OiEQvF2= NGT1bHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEmyO|gxOSd-Mki5Nlc5ODF:L3G+
A549 MX3DfZRwfG:6aXPpeJkh[XO|YYm= MkW5TWM2OCB;IEKuPVIh|ryP MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd5N{CwPUc,Ojd5N{ewNFk9N2F-
ZR75-30 M{PHW2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2PRfWlEPTBiPTCyMlk3KM7:TR?= NUXzOW9RRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxNFIyPzVpPkK5NVAzOTd3PD;hQi=>
PC3 M2\mPGN6fG:2b4jpZ4l1gSCjc4PhfS=> M{nsc2lEPTBiPTCzMlA{KM7:TR?= NGHMXGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEO0NFkyOyd-MkizOFA6OTN:L3G+
MDA-MB-231 NEDmbXNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NITGN3lKSzVyIE2gN{4xQCEQvF2= MoDOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ7OUG5N|goRjJ4OUmxPVM5RC:jPh?=
A549 NIi4PY5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYnJR|UxKD1iMz6xJO69VQ>? M1L5XlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUCyNVc2Lz5{OUGwNlE4PTxxYU6=
K562 MoXvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUeybJo3T0l3MDC9JFMvOTZizszN NFzROIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
MOLT4 NW\zSoN7T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXW1UZhQT0l3MDC9JFMvOTZizszN MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
A549/ATCC NUD1THpvT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVrERY5LT0l3MDC9JFMvOTZizszN MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
RPMI8226 MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NX3HbWZ[XEeLIE2gN{4yPiEQvF2= MlvzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
SR MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFX4dFdIUTVyIE2gN{4yPiEQvF2= MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
HOP62 NEfQeFFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHHkUWNVT0liPTCzMlE3KM7:TR?= M4XSTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
NCI-H226 MmOxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnrlWGdKKD1iMz6xOkDPxE1? NXqyNYNxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
U251 MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXXUS2khRSB|LkG2JO69VQ>? MnS5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
COLO205 NWDKT|hDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFXocnRVT0liPTCzMlE3KM7:TR?= M1\DblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
M14 MkT6S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3jmWnRIUSB;IEOuNVYh|ryP MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
HCC2998 M2C3cWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkD2S2k2OCB;IEOuNVYh|ryP M1XWNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
SNB75 MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1rjSWdKPTBiPTCzMlE3KM7:TR?= M4fDfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
786-0 M4jTS2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYmxd4c4T0l3MDC9JFMvOTZizszN M4\zOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
A498 MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXn2e3ZFXEeLIE2gN{4yPiEQvF2= NFyyWYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
HCT15 M{H0OWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVTQPZBiXEeLIE2gN{4yPiEQvF2= MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
OVCAR3 MlTsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NILvSGZIUTVyIE2gN{4yPiEQvF2= NYLEO4hTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
OVCAR4 MnrFS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmXBS2k2OCB;IEOuNVYh|ryP MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
Caki1 NYr6OnpWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWnzN4JUT0l3MDC9JFMvOTZizszN MkfuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
SNB19 M4nJV2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYTHTVUxKD1iMz6xOkDPxE1? MonSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
OVCAR5 MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1W4ZWdKPTBiPTCzMlE3KM7:TR?= MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
DU145 NELqO4VIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWq3fW1yT0l3MDC9JFMvOTZizszN NVLoPXQ1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
OVCAR8 M{TpS2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWPHTVUxKD1iMz6xOkDPxE1? MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
SN12C MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVLUS2khRSB|LkG2JO69VQ>? NUT0cHpYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
MDA-MB-231 Ml7pS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVLEdox{XEeLIE2gN{4yPiEQvF2= MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
RXF393 M{nGOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFvVS45IUTVyIE2gN{4yPiEQvF2= MnLqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
BT549 NYDqVIRMT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnKwS2k2OCB;IEOuNVYh|ryP NVvNNY9IRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
K562 MVvDfZRwfG:6aXPpeJkh[XO|YYm= NFzuPFBIUTVyIE2gN{4yPiEQvF2= NYD2SlRERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1PVA2ODhpPkK2OVkxPTB6PD;hQi=>
MOLT4 NIDVTmhEgXSxdH;4bYNqfHliYYPzZZk> MmjmS2k2OCB;IEOuNVYh|ryP NGPQdJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
SNB19 NUX1eFd5S3m2b4TvfIlkcXS7IHHzd4F6 MXHHTVUxKD1iMz6xOkDPxE1? MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
SR M3TZZWN6fG:2b4jpZ4l1gSCjc4PhfS=> M1XINGdKPTBiPTCzMlE3KM7:TR?= NIqwTXA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
A549 NYfuT5RxS3m2b4TvfIlkcXS7IHHzd4F6 MW\HTVUxKD1iMz6xOkDPxE1? M4LEVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUmwOVA5Lz5{NkW5NFUxQDxxYU6=
OVCAR3 MYTDfZRwfG:6aXPpeJkh[XO|YYm= MUXHTVUxKD1iMz6xOkDPxE1? M3;TNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUmwOVA5Lz5{NkW5NFUxQDxxYU6=
OVCAR4 MoHQR5l1d3SxeHnjbZR6KGG|c3H5 NEHEPYNIUTVyIE2gN{4yPiEQvF2= NV7yXoZRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1PVA2ODhpPkK2OVkxPTB6PD;hQi=>
SNB75 M1PwdWN6fG:2b4jpZ4l1gSCjc4PhfS=> Mmm1S2k2OCB;IEOuNVYh|ryP NYnXeGJORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1PVA2ODhpPkK2OVkxPTB6PD;hQi=>
OVCAR5 Mof6R5l1d3SxeHnjbZR6KGG|c3H5 Mk\hS2k2OCB;IEOuNVYh|ryP M1Lr[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUmwOVA5Lz5{NkW5NFUxQDxxYU6=
DU145 NHPNOXVEgXSxdH;4bYNqfHliYYPzZZk> NV60UXZkT0l3MDC9JFMvOTZizszN MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
786-0 Ml7CR5l1d3SxeHnjbZR6KGG|c3H5 MWDHTVUxKD1iMz6xOkDPxE1? MkPzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
BT549 NUXUSI9YS3m2b4TvfIlkcXS7IHHzd4F6 NVLFO|I4T0l3MDC9JFMvOTZizszN Mn7DQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
ACHN NVrzW29PS3m2b4TvfIlkcXS7IHHzd4F6 MmK1S2k2OCB;IEOuNVYh|ryP NHrQ[lg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
Caki1 Mlz3R5l1d3SxeHnjbZR6KGG|c3H5 M3\HUWdKPTBiPTCzMlE3KM7:TR?= MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
786-0 MVTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MYjHTVUxKD1iMz6xOkDPxE1? MlLMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
LOXIMVI NVrWd4hbSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NIK3bJBVT0liPTCzMlE3KM7:TR?=