Sorafenib (BAY 43-9006)

For research use only. Not for use in humans.

製品コードS7397 別名:NSC-724772

Sorafenib (BAY 43-9006)化学構造

CAS No. 284461-73-0

Sorafenib (BAY 43-9006, NSC-724772) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.

サイズ 価格(税別)  
JPY 26400
JPY 46800
JPY 113200
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バルク問合せ

文献中Selleckの製品使用例(369)

製品安全説明書

Raf阻害剤の選択性比較

生物活性

製品説明 Sorafenib (BAY 43-9006, NSC-724772) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.
ターゲット
Raf-1 [1]
(Cell-free assay)
mVEGFR2(Flk1) [1]
(Cell-free assay)
mVEGFR3 [1]
(Cell-free assay)
B-Raf [1]
(Cell-free assay)
B-Raf (V599E) [1]
(Cell-free assay)
6 nM 15 nM 20 nM 22 nM 38 nM
体外試験

Sorafenib inhibits both wild-type and V599E mutant B-Raf activity with IC50 of 22 nM and 38 nM, respectively. Sorafenib also potently inhibits mVEGFR2 (Flk-1), mVEGFR3, mPDGFRβ, Flt3, and c-Kit with IC50 of 15 nM, 20 nM, 57 nM, 58 nM, and 68 nM, respectively. Sorafenib weakly inhibits FGFR-1 with IC50 of 580 nM. Sorafenib tosylate is not active against ERK-1, MEK-1, EGFR, HER-2, IGFR-1, c-Met, PKB, PKA, cdk1/cyclinB, PKCα, PKCγ, and pim-1. Sorafenib markedly inhibits VEGFR2 phosphorylation in NIH 3T3 cells with IC50 of 30 nM, and Flt-3 phosphorylation in HEK-293 cells with IC50 of 20 nM. Sorafenib potently blocks MEK 1/2 and ERK 1/2 phosphorylation in most cell lines but not in A549 or H460 cells, while having no effect on inhibition of the PKB pathway. Sorafenib inhibits the proliferation of HAoSMC and MDA-MB-231 cells with IC50 of 0.28 μM and 2.6 μM, respectively. [1] In addition to inhibition of the RAF/MEK/ERK signaling pathway, Sorafenib significantly inhibits the phosphorylation of eIF4E and down-regulates Mcl-1 levels in hepatocellular carcinoma (HCC) cells in a MEK/ERK-independent manner. Sorafenib inhibits the proliferation of PLC/PRF/5 and HepG2 cells with IC50 of 6.3 μM and 4.5 μM, respectively, and leads to the significant induction of apoptosis. [2]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MV-4-11 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17aWGlEPTB;MD6wNFAxODNyMzFOwG0> M3mxS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
MONO-MAC-6 MmLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHO0OmlKSzVyPUCuNFA1OThizszN NWfDUXA1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
ALL-PO MlvSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGS1bYFKSzVyPUCuNFMyQDRizszN M3TMR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
NKM-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDoNFRKSzVyPUCuNFc1OTZizszN MmfUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVM{Pi9pPmPBUmdGWjxxYU6=
CGTH-W-1 NUnsT|gxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfsS3NkUUN3ME2wMlI2ODJ{IN88US=> NH\YVVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
BB65-RCC NXLENpdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwNEewO|Mh|ryP M4fEVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
NOS-1 NXu4V4pET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfwfXVIUUN3ME2wMlU3OzZizszN MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
SH-4 Mk\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\pUplKSzVyPUCuOlU3OTNizszN M{XXdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
HOP-62 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTLbWVRUUN3ME2wMlg2ODh6IN88US=> MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
HCC2998 NILzWI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwOEi4NVgh|ryP MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
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KM12 NXzIXYp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PDdmlEPTB;MT6wNlA6QCEQvF2= NHPBSWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
LB2518-MEL MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XQNWlEPTB;MT6yNFgxQSEQvF2= NVrVWGlpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
NCI-H1436 M17P[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHjOVh3UUN3ME2xMlIyPjd6IN88US=> M17DeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
EM-2 NVr0TIl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XtdGlEPTB;MT6zOVU4QCEQvF2= M3PSb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
LAMA-84 MoDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvlS5JKSzVyPUGuN|c3PDhizszN M2fkb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
KG-1 NYnFNYw6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfSTlBYUUN3ME2xMlQ4QTN3IN88US=> NHKxV4s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
A388 NHXNR5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHSzVoRKSzVyPUGuOVkyPjVizszN NFvRcnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
no-10 MoTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vDPGlEPTB;MT62NVczPiEQvF2= M1SzOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
SF126 NHjXR2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTFwNkO4NVIh|ryP NFXyT2I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
MEG-01 NI\oVIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlr6TWM2OD1zLkiwPVgh|ryP MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
A3-KAW Mm[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTFwOEi0NkDPxE1? MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
D-247MG MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPNTWM2OD1{LkG0OFgh|ryP NVzRSHVwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
OVCAR-4 M1vXWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TGdGlEPTB;Mj6yNVM6OyEQvF2= MnHBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVM{Pi9pPmPBUmdGWjxxYU6=
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NCI-H2171 NFfJPGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HwTGlEPTB;Mj6zPVc3PCEQvF2= NVLL[VVURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
SIG-M5 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTESGNoUUN3ME2yMlQzOjR{IN88US=> NILGOm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
BE-13 Ml;QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjNTWM2OD1{Lk[5OlA6KM7:TR?= NUP6Z|ZzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
K052 NInyVIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTJwN{S2NVYh|ryP NWPhPZZ1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
L-540 M1rkVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDpVldnUUN3ME2yMlc2Pzh7IN88US=> NFXPd5g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
KMOE-2 NHvzWGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrMZmVmUUN3ME2yMlgyOzVizszN NWH3ZnVzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
MFH-ino NFLHfmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rjZ2lEPTB;Mj65NlE5PSEQvF2= MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
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MRK-nu-1 NXnWSHp7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPlWFh2UUN3ME2zMlYyPDZ6IN88US=> NHHJc4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
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KS-1 NVfC[WN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLzV|h1UUN3ME2zMlg5OTl6IN88US=> MmLiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVM{Pi9pPmPBUmdGWjxxYU6=
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rhabdomyosarcoma NWfUWZlNSW62aY\pdoFtKGGldHn2bZR6KGG|c3H5 Mli2SWM2OCB;IEGuOUDPxE1? NF\SZnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{K4PFE5Pid-MkeyPFgyQDZ:L3G+
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U937 NUnGUIxqS3m2b4TvfIlkcXS7IHHzd4F6 M4OzUmdKPTBiPTCyMlc1KM7:TR?= MmDNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6N{ixPVMoRjJ2OEe4NVk{RC:jPh?=
MCF7 NFztcnZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NILXRm5KSzVyIE2gNk44QCEQvF2= M2LVZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUCyNVc2Lz5{OUGwNlE4PTxxYU6=
MDA-MB-231 MX7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NWrUNYFMUUN3MDC9JFIvQCEQvF2= NIf2VGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUKwNlQxOyd-MkmyNFI1ODN:L3G+
HepG2 NF7pNm5CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MmPwTWM2OCB;IEKuPFQh|ryP MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ2MkW1N{c,Ojh{NEK1OVM9N2F-
U937 MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGTSSFdIUTVyIE2gNk45PSEQvF2= M3XKWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MEG0O|U2Lz5{MkCxOFc2PTxxYU6=
A549 M2fNPGN6fG:2b4jpZ4l1gSCjc4PhfS=> M4rjfWlEPTBiPTCyMlkzKM7:TR?= MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl{N{iwNUc,Ojh7Mke4NFE9N2F-
A549 M1;BT2N6fG:2b4jpZ4l1gSCjc4PhfS=> NGnxcY9KSzVyIE2gNk46OiEQvF2= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd5N{CwPUc,Ojd5N{ewNFk9N2F-
ZR75-30 MlHXS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYjJR|UxKD1iMj65OkDPxE1? MmryQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlzMEKxO|UoRjJ7MUCyNVc2RC:jPh?=
PC3 NGL0[VFEgXSxdH;4bYNqfHliYYPzZZk> MUjJR|UxKD1iMz6wN{DPxE1? M1LodFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{SwPVE{Lz5{OEO0NFkyOzxxYU6=
MDA-MB-231 NHX5T45CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NXvtb5ptUUN3MDC9JFMvODhizszN NWrRfYs1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[5PVE6OzhpPkK2PVkyQTN6PD;hQi=>
A549 M2\RS2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUHJR|UxKD1iMz6xJO69VQ>? NGC3blI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUGwNlE4PSd-MkmxNFIyPzV:L3G+
K562 NF;yVoNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVLHTVUxKD1iMz6xOkDPxE1? MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
MOLT4 Mlq3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{fmdWdKPTBiPTCzMlE3KM7:TR?= M2\FTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
A549/ATCC M{fpZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXvsN20zT0l3MDC9JFMvOTZizszN MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
RPMI8226 MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUnUS2khRSB|LkG2JO69VQ>? NHPi[IU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
SR Mn;4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYHHTVUxKD1iMz6xOkDPxE1? Mn3VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
HOP62 NXS5c2NKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3jQfXRIUSB;IEOuNVYh|ryP NUD0elN2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
NCI-H226 NIH4eFJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUPUS2khRSB|LkG2JO69VQ>? M1jaV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
U251 MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkHOWGdKKD1iMz6xOkDPxE1? NHPITmY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
COLO205 M2rHZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXLUS2khRSB|LkG2JO69VQ>? MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
M14 MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUHUS2khRSB|LkG2JO69VQ>? MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
HCC2998 NYHrZotST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFH1OnRIUTVyIE2gN{4yPiEQvF2= Mk\nQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
SNB75 NETi[FJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXPHTVUxKD1iMz6xOkDPxE1? MnPVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
786-0 M1Syemdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NF;6bGlIUTVyIE2gN{4yPiEQvF2= NWToeJgyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
A498 NV[0OphoT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFTwellVT0liPTCzMlE3KM7:TR?= M{nuT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
HCT15 MoHBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{PLcHRIUSB;IEOuNVYh|ryP MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
OVCAR3 NGry[ZpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWXHTVUxKD1iMz6xOkDPxE1? Ml\YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
OVCAR4 M2nteWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3XKW2dKPTBiPTCzMlE3KM7:TR?= NF22W3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
Caki1 M2rFfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFHJUXpIUTVyIE2gN{4yPiEQvF2= NF\EcJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
SNB19 NWLDS5Z1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHryV2pIUTVyIE2gN{4yPiEQvF2= NX3scVBwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
OVCAR5 NYH6XJIxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGfveZdIUTVyIE2gN{4yPiEQvF2= NX7MdG1URGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
DU145 MmXFS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2\DUWdKPTBiPTCzMlE3KM7:TR?= NIjXWI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
OVCAR8 MkS0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnrUS2k2OCB;IEOuNVYh|ryP M3zzblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
SN12C MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXjUS2khRSB|LkG2JO69VQ>? MmXiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
MDA-MB-231 NIfIW2ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXrifY9CXEeLIE2gN{4yPiEQvF2= NUKwXYFsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
RXF393 M3vGWWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{nUUGdKPTBiPTCzMlE3KM7:TR?= MlvDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
BT549 MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXHHTVUxKD1iMz6xOkDPxE1? NXvCW4xPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
K562 MmPUR5l1d3SxeHnjbZR6KGG|c3H5 NHHmfJdIUTVyIE2gN{4yPiEQvF2= NE[0e2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
MOLT4 M3zsVmN6fG:2b4jpZ4l1gSCjc4PhfS=> M1O4e2dKPTBiPTCzMlE3KM7:TR?= NIfsZ4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
SNB19 NVnyW5h7S3m2b4TvfIlkcXS7IHHzd4F6 NEjEcZJIUTVyIE2gN{4yPiEQvF2= NVTrbWQ5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1PVA2ODhpPkK2OVkxPTB6PD;hQi=>
SR M3XBRmN6fG:2b4jpZ4l1gSCjc4PhfS=> MnHXS2k2OCB;IEOuNVYh|ryP NELzb5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
A549 NH7RNVdEgXSxdH;4bYNqfHliYYPzZZk> NXjyTo85T0l3MDC9JFMvOTZizszN MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
OVCAR3 M3;lNWN6fG:2b4jpZ4l1gSCjc4PhfS=> NF3JSY1IUTVyIE2gN{4yPiEQvF2= NV\NcZhZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1PVA2ODhpPkK2OVkxPTB6PD;hQi=>
OVCAR4 Ml3lR5l1d3SxeHnjbZR6KGG|c3H5 MVvHTVUxKD1iMz6xOkDPxE1? NHvNcoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
SNB75 NX7VbVh1S3m2b4TvfIlkcXS7IHHzd4F6 Mli0S2k2OCB;IEOuNVYh|ryP MmK2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
OVCAR5 M2LtO2N6fG:2b4jpZ4l1gSCjc4PhfS=> MlOxS2k2OCB;IEOuNVYh|ryP NVfaVW1VRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1PVA2ODhpPkK2OVkxPTB6PD;hQi=>
DU145 Ml6xR5l1d3SxeHnjbZR6KGG|c3H5 NXfN[Ic1T0l3MDC9JFMvOTZizszN NHj1WYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
786-0 NVvWS3I{S3m2b4TvfIlkcXS7IHHzd4F6 NVLlS|R[T0l3MDC9JFMvOTZizszN NIHVWm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
BT549 MmTKR5l1d3SxeHnjbZR6KGG|c3H5 NVywSpZZT0l3MDC9JFMvOTZizszN NEHWVnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
ACHN NWL5NYVoS3m2b4TvfIlkcXS7IHHzd4F6 NX62Z29YT0l3MDC9JFMvOTZizszN NHLOXFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
Caki1 NWLtTlBpS3m2b4TvfIlkcXS7IHHzd4F6 M1rne2dKPTBiPTCzMlE3KM7:TR?= M2Hld|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUmwOVA5Lz5{NkW5NFUxQDxxYU6=
786-0 NH\yNpJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MmX4S2k2OCB;IEOuNVYh|ryP M1j2PVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
LOXIMVI NELBVI9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MYrUS2khRSB|LkG2JO69VQ>? Mlz0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
Caki1 M2K5fWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MkXBS2k2OCB;IEOuNVYh|ryP NGX4eHc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
OVCAR5 NHXMZ3ZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M{LOOGdKPTBiPTCzMlE3KM7:TR?= NXTaOJgxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
RXF393 MUDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MmP4S2k2OCB;IEOuNVYh|ryP MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
SNB75 MWDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NWDYPXhIT0l3MDC9JFMvOTZizszN NHnnWoE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
OVCAR3 NETTU|hCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NWHPSlR4T0l3MDC9JFMvOTZizszN M37MclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
SNB19 MkfPRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M4LCdmdKPTBiPTCzMlE3KM7:TR?= NUP4eY1mRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
SK-MEL-5 NEnpWItCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M4fmO3RIUSB;IEOuNVYh|ryP M3n4eVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
OVCAR4 MoO3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MUXHTVUxKD1iMz6xOkDPxE1? NIK5XmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
SK-MEL-2 NVv4Znc{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M376WXRIUSB;IEOuNVYh|ryP NELvOGY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
BT549 NUjHeY1ISW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MmGxS2k2OCB;IEOuNVYh|ryP NYTV[|RyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
MOLT4 NX3qTJdLSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NYGyVIJ5T0l3MDC9JFMvOTZizszN NUi3cFFkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
K562 MlrpRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NYjJ[FluT0l3MDC9JFMvOTZizszN MknPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
HCC2998 MWHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NYm1Z29IT0l3MDC9JFMvOTZizszN M3zwXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
HCC2998 M4jifWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NYjvTFllXEeLIE2gN{4yPiEQvF2= MoPTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
A549/ATCC MUTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NWHRc5ZkT0l3MDC9JFMvOTZizszN MlLPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
DU145 MVnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NXzOe4loT0l3MDC9JFMvOTZizszN MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
SR MYjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NWnHOmd5T0l3MDC9JFMvOTZizszN MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
MCF7 NEPoeFJEgXSxdH;4bYNqfHliYYPzZZk> NWXENlFOUUN3MDC9JFMvOThizszN NUPkWIl{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5Nlc5ODFpPkK4PVI4QDBzPD;hQi=>
PC3 M{XSeGN6fG:2b4jpZ4l1gSCjc4PhfS=> NVH3d5ZwUUN3MDC9JFMvOThizszN NUW0dZhsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5Nlc5ODFpPkK4PVI4QDBzPD;hQi=>
MCF7 MonmR5l1d3SxeHnjbZR6KGG|c3H5 NGmwNnVKSzVyIE2gN{4yQCEQvF2= Mn21QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5N{ewNFkoRjJ5N{e3NFA6RC:jPh?=
A549 NEPIboVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NIiybphKSzVyIE2gN{4yQSEQvF2= MnzRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5N{i5PVUoRjJ3N{e4PVk2RC:jPh?=
PC3 MUDDfZRwfG:6aXPpeJkh[XO|YYm= M16zd2lEPTBiPTCzMlI1KM7:TR?= NGDwNJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e3O|AxQSd-Mke3O|cxODl:L3G+
HeLa NVjMS|FqTnWwY4Tpc44h[XO|YYm= MWPJR|UxKD1iMz6zJO69VQ>? NH3TVFI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUKyOVcxPid-MUWyNlU4ODZ:L3G+
HeLa M1Pi[2Z2dmO2aX;uJIF{e2G7 M4DBfGlEPTBiPTCzMlMh|ryP MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTJ{NUewOkc,OTV{MkW3NFY9N2F-
LoVo MXTDfZRwfG:6aXPpeJkh[XO|YYm= MoW0TWM2OCB;IEOuN{DPxE1? MmX1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2NUSwNVcoRjJ|NEW0NFE4RC:jPh?=
A375 NFnlZZFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NFXaWHRKSzVyIE2gN{4{PiEQvF2= NFrmN489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[wNlY4PCd-Mkm2NFI3PzR:L3G+
HT-29 NFrKWW1CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M2e3fGlEPTBiPTCzMlM4KM7:TR?= M1;xflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OUmxPVM5Lz5{Nkm5NVk{QDxxYU6=
FLT3 gene-deficient U937 NH\zTXhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MYHHTVUxKD1iMz60JO69VQ>? MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTdyOES2PEc,OjF5MEi0Olg9N2F-
FLT3 negative U937 NH;ZO2NEgXSxdH;4bYNqfHliYYPzZZk> NUHIO2pLT0l3MDC9JFMvPCEQvF2= MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZzOEewPUc,OjN4MUi3NFk9N2F-
U937 NXm1N5hxS3m2b4TvfIlkcXS7IHHzd4F6 NWf5U5gzT0l3MDC9JFMvPCEQvF2= M4XLd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MEixNFI{Lz5{NkC4NVAzOzxxYU6=
A375P NXe5S5c5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M4[4cmdKPTBiPTCzMlQh|ryP M4\NUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEW5NVQ1Lz5{OUS1PVE1PDxxYU6=
ACHN M1XUXmN6fG:2b4jpZ4l1gSCjc4PhfS=> MWPJR|UxKD1iMz60JO69VQ>? NUXFRVVORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1NVc6ODhpPkK5OVE4QTB6PD;hQi=>
ACHN M3zWSWN6fG:2b4jpZ4l1gSCjc4PhfS=> M3jYcWlEPTBiPTCzMlQh|ryP NX7iOpFKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmyPVc3QDhpPkK5Nlk4Pjh6PD;hQi=>
HepG2 NVvYNnh6TnWwY4Tpc44h[XO|YYm= NHzWcoxKSzVyIE2gN{41KM7:TR?= M3LnWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MEexPFYyLz5{NkC3NVg3OTxxYU6=
A375P MWLDfZRwfG:6aXPpeJkh[XO|YYm= MVXHTVUxKD1iMz60JO69VQ>? M2jhUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEe4NVk{Lz5{NEi3PFE6OzxxYU6=
HepG2 NHzGWGpEgXSxdH;4bYNqfHliYYPzZZk> NEfPR2tKSzVyIE2gN{41PCEQvF2= MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl{N{iwNUc,Ojh7Mke4NFE9N2F-
HepG2 MYDDfZRwfG:6aXPpeJkh[XO|YYm= M37Yc2lEPTBiPTCzMlQ1KM7:TR?= NUDid|d4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3O|cxODlpPkK3O|c4ODB7PD;hQi=>
ACHN NX6wR5QzS3m2b4TvfIlkcXS7IHHzd4F6 M1zTZmlEPTBiPTCzMlUh|ryP M3zESVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7N{i2OFM3Lz5{OUe4OlQ{PjxxYU6=
HepG2 MYPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NFnPSmVKSzVyIE2gN{42KM7:TR?= NHvLSI89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS2NlI3PSd-MkW0OlIzPjV:L3G+
HT-29 MUHDfZRwfG:6aXPpeJkh[XO|YYm= NV\yVJhrUUN3MDC9JFMvPjFizszN NX\XSJZvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4NlY5OTVpPkK0PFI3QDF3PD;hQi=>
HT-29 NITMNWRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NGnJfVdKSzVyIE2gN{43OSEQvF2= MlnOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MU[4OFkoRjNyMkG2PFQ6RC:jPh?=