Sorafenib

For research use only. Not for use in humans.

製品コードS7397 別名:BAY 43-9006

Sorafenib化学構造

CAS No. 284461-73-0

Sorafenib (BAY 43-9006) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.

サイズ 価格(税別)  
JPY 26400
JPY 46800
JPY 113200
最寄りの販売代理店を探す

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バルク問合せ

文献中Selleckの製品使用例(347)

製品安全説明書

Raf阻害剤の選択性比較

生物活性

製品説明 Sorafenib (BAY 43-9006) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.
ターゲット
Raf-1 [1]
(Cell-free assay)
mVEGFR2(Flk1) [1]
(Cell-free assay)
mVEGFR3 [1]
(Cell-free assay)
B-Raf [1]
(Cell-free assay)
B-Raf (V599E) [1]
(Cell-free assay)
6 nM 15 nM 20 nM 22 nM 38 nM
体外試験

Sorafenib inhibits both wild-type and V599E mutant B-Raf activity with IC50 of 22 nM and 38 nM, respectively. Sorafenib also potently inhibits mVEGFR2 (Flk-1), mVEGFR3, mPDGFRβ, Flt3, and c-Kit with IC50 of 15 nM, 20 nM, 57 nM, 58 nM, and 68 nM, respectively. Sorafenib weakly inhibits FGFR-1 with IC50 of 580 nM. Sorafenib tosylate is not active against ERK-1, MEK-1, EGFR, HER-2, IGFR-1, c-Met, PKB, PKA, cdk1/cyclinB, PKCα, PKCγ, and pim-1. Sorafenib markedly inhibits VEGFR2 phosphorylation in NIH 3T3 cells with IC50 of 30 nM, and Flt-3 phosphorylation in HEK-293 cells with IC50 of 20 nM. Sorafenib potently blocks MEK 1/2 and ERK 1/2 phosphorylation in most cell lines but not in A549 or H460 cells, while having no effect on inhibition of the PKB pathway. Sorafenib inhibits the proliferation of HAoSMC and MDA-MB-231 cells with IC50 of 0.28 μM and 2.6 μM, respectively. [1] In addition to inhibition of the RAF/MEK/ERK signaling pathway, Sorafenib significantly inhibits the phosphorylation of eIF4E and down-regulates Mcl-1 levels in hepatocellular carcinoma (HCC) cells in a MEK/ERK-independent manner. Sorafenib inhibits the proliferation of PLC/PRF/5 and HepG2 cells with IC50 of 6.3 μM and 4.5 μM, respectively, and leads to the significant induction of apoptosis. [2]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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MONO-MAC-6 NV7MT|d5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13ESWlEPTB;MD6wNFQyQCEQvF2= M1Hs[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
ALL-PO MnnwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMEOxPFQh|ryP M1X0SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
NKM-1 NVLuSW5bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;RVoZKSzVyPUCuNFc1OTZizszN NIrUR5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
CGTH-W-1 NEPPXY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIL3cGpKSzVyPUCuNlUxOjJizszN NHzpRmw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
BB65-RCC NV7SfWU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzxc2RKSzVyPUCuOFcxPzNizszN NI\NO5g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
NOS-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3ThT2lEPTB;MD61OlM3KM7:TR?= NWPMcY5SRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
SH-4 NYLwRW42T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHL3TXlKSzVyPUCuOlU3OTNizszN M2[1bFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
HOP-62 NVm0c|QzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHudmxKSzVyPUCuPFUxQDhizszN Moi3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVM{Pi9pPmPBUmdGWjxxYU6=
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LB2518-MEL NFzGPXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXNfGdKSzVyPUGuNlA5ODlizszN MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
NCI-H1436 NILuU3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTFwMkG2O|gh|ryP M1jydlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
EM-2 NEizXlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfSRlJpUUN3ME2xMlM2PTd6IN88US=> NXrRdWMyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
LAMA-84 NGDJUXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nROWlEPTB;MT6zO|Y1QCEQvF2= NFKwemo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
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rhabdomyosarcoma NVXkPVZ[SW62aY\pdoFtKGGldHn2bZR6KGG|c3H5 NFe2cVFGSzVyIE2gNU42KM7:TR?= NXn3foZMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkeyPFgyQDZpPkK3Nlg5OTh4PD;hQi=>
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KM12 M2nScWN6fG:2b4jpZ4l1gSCjc4PhfS=> Ml3HS2k2OCB;IEGuOVgh|ryP NWPpPGlzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1PVA2ODhpPkK2OVkxPTB6PD;hQi=>
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MDA-MB-435 M2ToZmN6fG:2b4jpZ4l1gSCjc4PhfS=> M3iwPWdKPTBiPTCxMlU5KM7:TR?= MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
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KM12 NEPlc25CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NFv4NnpIUTVyIE2gNU42QCEQvF2= M1PzU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
MDA-MB-435 NFLK[2xCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MXnHTVUxKD1iMT61PEDPxE1? NFLHfZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
SF539 NXTu[Wc{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MnzES2k2OCB;IEGuOVgh|ryP Mon2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
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HCT116 NUHxe4loSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NXzRS3NwT0l3MDC9JFEvPThizszN NV\ybGFqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
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MDA-MB-435 Mn;2RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NUP1UW5rUUN3MDC9JFEvPjdizszN NWjKV|UzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3O|g6QTVpPkK1O|c5QTl3PD;hQi=>
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MDA-MB-231 M3m1[mN6fG:2b4jpZ4l1gSCjc4PhfS=> M4HiNWlEPTBiPTCyJO69VQ>? NWezfZlCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0OVQxOTdpPkKzOFU1ODF5PD;hQi=>
NCI-H23 MkLHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4PZTmdKPTBiPTCyJO69VQ>? NYXrZ5NqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
NCI-H522 NVjjfopIT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkD1S2k2OCB;IEKg{txO NUnXcJl[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
HOP62 MmXRS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlTOS2k2OCB;IEKg{txO NWTGXJIzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
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U251 NGCyepVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH70VmdIUTVyIE2gNkDPxE1? MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
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A549/ATCC MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Ml\pS2k2OCB;IEOuNVYh|ryP NX7JVIw{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
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A498 NF3iUllIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHf2U21VT0liPTCzMlE3KM7:TR?= M2XmUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
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DU145 Mn7jS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVnHTVUxKD1iMz6xOkDPxE1? NH\aNVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
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MDA-MB-231 Moq2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVqwZm5ZXEeLIE2gN{4yPiEQvF2= NECxcJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
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RXF393 Mn7iRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? Mn3ZS2k2OCB;IEOuNVYh|ryP MnHOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
SNB75 NVnre4tRSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M{DhZ2dKPTBiPTCzMlE3KM7:TR?= NFWxU5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
OVCAR3 MW\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MkTqS2k2OCB;IEOuNVYh|ryP MmO2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
SNB19 NUPhS3A{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= Mnn1S2k2OCB;IEOuNVYh|ryP M3XlT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
SK-MEL-5 NF7xfppCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MXLUS2khRSB|LkG2JO69VQ>? M1Tkd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
OVCAR4 M1fUcGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 Mo\rS2k2OCB;IEOuNVYh|ryP Ml;rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
SK-MEL-2 MnjzRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MXHUS2khRSB|LkG2JO69VQ>? NW\HXIJpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
BT549 MXXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? Mmj2S2k2OCB;IEOuNVYh|ryP M17UUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
MOLT4 NHfXe|VCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MVvHTVUxKD1iMz6xOkDPxE1? NYPqVmFnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
K562 NV3yO4ZlSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MVTHTVUxKD1iMz6xOkDPxE1? MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
HCC2998 M3TDRmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M4rqUmdKPTBiPTCzMlE3KM7:TR?= NGnxeGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
HCC2998 NXXZPHpVSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NV34bFlRXEeLIE2gN{4yPiEQvF2= MnjpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
A549/ATCC MVjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MVTHTVUxKD1iMz6xOkDPxE1? MnzVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
DU145 NHPobmJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M1vkVmdKPTBiPTCzMlE3KM7:TR?= Ml\2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
SR M1nV[WFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MXfHTVUxKD1iMz6xOkDPxE1? NXntUlJtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
MCF7 MnrZR5l1d3SxeHnjbZR6KGG|c3H5 MXjJR|UxKD1iMz6xPEDPxE1? MlfsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7Mke4NFEoRjJ6OUK3PFAyRC:jPh?=
PC3 MW\DfZRwfG:6aXPpeJkh[XO|YYm= NXfhcZBpUUN3MDC9JFMvOThizszN M{TNU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUK3PFAyLz5{OEmyO|gxOTxxYU6=
MCF7 MYXDfZRwfG:6aXPpeJkh[XO|YYm= MnjaTWM2OCB;IEOuNVgh|ryP NHvjTow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e3O|AxQSd-Mke3O|cxODl:L3G+
A549 NEXrdpdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MX3JR|UxKD1iMz6xPUDPxE1? NEXUcGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe3PFk6PSd-MkW3O|g6QTV:L3G+
PC3 NFjoR25EgXSxdH;4bYNqfHliYYPzZZk> NWDIXIhzUUN3MDC9JFMvOjRizszN MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd5N{CwPUc,Ojd5N{ewNFk9N2F-
HeLa NFi3VYZHfW6ldHnvckBie3OjeR?= MXrJR|UxKD1iMz6zJO69VQ>? NGjkcoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUKyOVcxPid-MUWyNlU4ODZ:L3G+
HeLa NHvBcXhHfW6ldHnvckBie3OjeR?= MX3JR|UxKD1iMz6zJO69VQ>? M1v0ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MkK1O|A3Lz5zNUKyOVcxPjxxYU6=
LoVo NFT5RXFEgXSxdH;4bYNqfHliYYPzZZk> NInDdFBKSzVyIE2gN{4{KM7:TR?= NGO2[ZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S1OFAyPyd-MkO0OVQxOTd:L3G+
A375 NG\xdHlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MmHQTWM2OCB;IEOuN|Yh|ryP Ml7kQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4MEK2O|QoRjJ7NkCyOlc1RC:jPh?=
HT-29 M2S4XGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MnnuTWM2OCB;IEOuN|ch|ryP MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjl7MUmzPEc,OjZ7OUG5N|g9N2F-
FLT3 gene-deficient U937 M4fafmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MlPpS2k2OCB;IEOuOEDPxE1? MmjuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF5MEi0OlgoRjJzN{C4OFY5RC:jPh?=
FLT3 negative U937 Mn7OR5l1d3SxeHnjbZR6KGG|c3H5 M4DvemdKPTBiPTCzMlQh|ryP NYHXNHdjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NVg4ODlpPkKzOlE5PzB7PD;hQi=>
U937 MYHDfZRwfG:6aXPpeJkh[XO|YYm= Ml;3S2k2OCB;IEOuOEDPxE1? MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjB6MUCyN{c,OjZyOEGwNlM9N2F-
A375P NYXDbZg4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MkHpS2k2OCB;IEOuOEDPxE1? NHLQXXU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUS1PVE1PCd-Mkm0OVkyPDR:L3G+
ACHN NV7WeWEzS3m2b4TvfIlkcXS7IHHzd4F6 M4rWSWlEPTBiPTCzMlQh|ryP NHvXd3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUWxO|kxQCd-Mkm1NVc6ODh:L3G+
ACHN MYrDfZRwfG:6aXPpeJkh[XO|YYm= MnexTWM2OCB;IEOuOEDPxE1? NIPSNIQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUK5O|Y5QCd-MkmyPVc3QDh:L3G+
HepG2 NVvUNIN6TnWwY4Tpc44h[XO|YYm= NXLvPGVIUUN3MDC9JFMvPCEQvF2= MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjB5MUi2NUc,OjZyN{G4OlE9N2F-
A375P NXLR[FByS3m2b4TvfIlkcXS7IHHzd4F6 MVvHTVUxKD1iMz60JO69VQ>? MkKzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6N{ixPVMoRjJ2OEe4NVk{RC:jPh?=
HepG2 MYfDfZRwfG:6aXPpeJkh[XO|YYm= MoXtTWM2OCB;IEOuOFQh|ryP NH[w[pc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEmyO|gxOSd-Mki5Nlc5ODF:L3G+
HepG2 MkHQR5l1d3SxeHnjbZR6KGG|c3H5 MVPJR|UxKD1iMz60OEDPxE1? NYHhSHd5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3O|cxODlpPkK3O|c4ODB7PD;hQi=>
ACHN MV7DfZRwfG:6aXPpeJkh[XO|YYm= MVPJR|UxKD1iMz61JO69VQ>? MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTd6NkSzOkc,Ojl5OE[0N|Y9N2F-
HepG2 MmLuRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NV;JbZExUUN3MDC9JFMvPSEQvF2= NWPaWWk6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0OlIzPjVpPkK1OFYzOjZ3PD;hQi=>
HT-29 NFvZZpVEgXSxdH;4bYNqfHliYYPzZZk> MnzjTWM2OCB;IEOuOlEh|ryP MnrGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6Mk[4NVUoRjJ2OEK2PFE2RC:jPh?=
HT-29 MV7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MUfJR|UxKD1iMz62NUDPxE1? MoPnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MU[4OFkoRjNyMkG2PFQ6RC:jPh?=
HT-29 MUjDfZRwfG:6aXPpeJkh[XO|YYm= NEnVZpZKSzVyIE2gN{43OSEQvF2= MmDrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyOE[yN|goRjJ3MEi2NlM5RC:jPh?=
HT-29 MXXDfZRwfG:6aXPpeJkh[XO|YYm= NGjwWmZKSzVyIE2gN{43OSEQvF2= NES4N249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS0NFg4QSd-MkW0OFA5Pzl:L3G+
MCF7 NEe3c2NCdnSrY3HuZ4VzKGGldHn2bZR6KGG|c3H5 NVXYUnh{UUN3MDC9JFMvPjRizszN NUPrR2RMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OFk5PDFpPkK5OVQ6QDRzPD;hQi=>
Sf9 MlL2SpVv[3Srb36gZZN{[Xl? M3nWUmlEPTBiPTCzMlgh|ryP M3;VPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{C4OFY5Lz5{MUewPFQ3QDxxYU6=
Sf9 NUL4NoZkTnWwY4Tpc44h[XO|YYm= NHe0enhKSzVyIE2gN{45KM7:TR?= NFO1WVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[xPFcxQSd-MkO2NVg4ODl:L3G+
Sf9 NW\OTlBSTnWwY4Tpc44h[XO|YYm= MYPJR|UxKD1iMz64JO69VQ>? Ml3xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyOEGwNlMoRjJ4MEixNFI{RC:jPh?=
A2058 MkmxR5l1d3SxeHnjbZR6KGG|c3H5 NHe0SolKSzVyIE2gN{45KM7:TR?= NWTQT4RoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK3NFg6QDdpPkKyO|A5QTh5PD;hQi=>
NCI-H460 NWrPPVJES3m2b4TvfIlkcXS7IHHzd4F6 M37V[mlEPTBiPTCzMlkh|ryP NWTL[VBMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0OVQxOTdpPkKzOFU1ODF5PD;hQi=>
SK-MEL-30 NGD1UFREgXSxdH;4bYNqfHliYYPzZZk> M3;mcWlEPTBiPTCzMlkh|ryP M2np[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NE[xPFI4Lz5{OUS2NVgzPzxxYU6=
HT-29 Mnf0RY51cWOjbnPldkBi[3Srdnn0fUBie3OjeR?= Ml3iTWM2OCB;IEOuPVch|ryP MnfrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NEm4OFEoRjJ7NUS5PFQyRC:jPh?=
SF268 M1\tVWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFrOVJlVT0liPTCzMlk5KM7:TR?= NFXNN4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
SNB75 MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFHH[YlVT0liPTCzMlk5KM7:TR?= NGnCWoE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
OVCAR3 M3nKVGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWT1cY55XEeLIE2gN{46QCEQvF2= Ml7CQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
SNB19 MorZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXX1WY9QXEeLIE2gN{46QCEQvF2= NIr0eIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
Hs 578T NHfkT4NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWnUS2khRSB|Lkm4JO69VQ>? NIPWUIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
TK10 MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NU[0PZBCT0l3MDC9JFMvQThizszN M1rWVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
BT549 MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHuye4NVT0liPTCzMlk5KM7:TR?= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
Caki1 M{HQeWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NVPN[op4XEeLIE2gN{46QCEQvF2= NWDMNoVkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
TK10 Mli1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NXe3XmJ[T0l3MDC9JFMvQThizszN MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
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