Sorafenib

For research use only. Not for use in humans.

製品コードS7397 別名:BAY 43-9006

Sorafenib化学構造

CAS No. 284461-73-0

Sorafenib (BAY 43-9006) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.

サイズ 価格(税別) 在庫  
JPY 26400 あり
JPY 46800 あり
JPY 113200 あり
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文献中Selleckの製品使用例(326)

製品安全説明書

Raf阻害剤の選択性比較

生物活性

製品説明 Sorafenib (BAY 43-9006) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.
ターゲット
Raf-1 [1]
(Cell-free assay)
mVEGFR2(Flk1) [1]
(Cell-free assay)
mVEGFR3 [1]
(Cell-free assay)
B-Raf [1]
(Cell-free assay)
B-Raf (V599E) [1]
(Cell-free assay)
6 nM 15 nM 20 nM 22 nM 38 nM
体外試験

Sorafenib inhibits both wild-type and V599E mutant B-Raf activity with IC50 of 22 nM and 38 nM, respectively. Sorafenib also potently inhibits mVEGFR2 (Flk-1), mVEGFR3, mPDGFRβ, Flt3, and c-Kit with IC50 of 15 nM, 20 nM, 57 nM, 58 nM, and 68 nM, respectively. Sorafenib weakly inhibits FGFR-1 with IC50 of 580 nM. Sorafenib tosylate is not active against ERK-1, MEK-1, EGFR, HER-2, IGFR-1, c-Met, PKB, PKA, cdk1/cyclinB, PKCα, PKCγ, and pim-1. Sorafenib markedly inhibits VEGFR2 phosphorylation in NIH 3T3 cells with IC50 of 30 nM, and Flt-3 phosphorylation in HEK-293 cells with IC50 of 20 nM. Sorafenib potently blocks MEK 1/2 and ERK 1/2 phosphorylation in most cell lines but not in A549 or H460 cells, while having no effect on inhibition of the PKB pathway. Sorafenib inhibits the proliferation of HAoSMC and MDA-MB-231 cells with IC50 of 0.28 μM and 2.6 μM, respectively. [1] In addition to inhibition of the RAF/MEK/ERK signaling pathway, Sorafenib significantly inhibits the phosphorylation of eIF4E and down-regulates Mcl-1 levels in hepatocellular carcinoma (HCC) cells in a MEK/ERK-independent manner. Sorafenib inhibits the proliferation of PLC/PRF/5 and HepG2 cells with IC50 of 6.3 μM and 4.5 μM, respectively, and leads to the significant induction of apoptosis. [2]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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MONO-MAC-6 MmnQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwMEC0NVgh|ryP MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
ALL-PO MlzlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;oZZlKSzVyPUCuNFMyQDRizszN NUG4WGVjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
NKM-1 NV\Td4R{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LRO2lEPTB;MD6wO|QyPiEQvF2= NHjQXnA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
CGTH-W-1 NHXYbWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwMkWwNlIh|ryP MonIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVM{Pi9pPmPBUmdGWjxxYU6=
BB65-RCC MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;IfWlEPTB;MD60O|A4OyEQvF2= MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
NOS-1 NUPTUWRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETmfW5KSzVyPUCuOVY{PiEQvF2= MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
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rhabdomyosarcoma NXPUUJlzSW62aY\pdoFtKGGldHn2bZR6KGG|c3H5 MmS1SWM2OCB;IEGuOUDPxE1? MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzJ6OEG4Okc,Ojd{OEixPFY9N2F-
HL-60(TB) M2jyV2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2\wfmdKPTBiPTCxMlU5KM7:TR?= MoqwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
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HL-60(TB) NWf1PIl5S3m2b4TvfIlkcXS7IHHzd4F6 MkW2S2k2OCB;IEGuOVgh|ryP MmLGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
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HCT116 MkHvRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M2XFdmdKPTBiPTCxMlU5KM7:TR?= MkfqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
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U937 MYPDfZRwfG:6aXPpeJkh[XO|YYm= NUXDSm1UT0l3MDC9JFIvPzRizszN M3jyNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEe4NVk{Lz5{NEi3PFE6OzxxYU6=
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MDA-MB-231 NHHXS49CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MmXITWM2OCB;IEKuPEDPxE1? NUK3Z3B4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmyNFI1ODNpPkK5NlAzPDB|PD;hQi=>
HepG2 NXvHPXF5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M1jwZ2lEPTBiPTCyMlg1KM7:TR?= MofGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{NEK1OVMoRjJ6MkSyOVU{RC:jPh?=
U937 NHXmdWlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3LDUmdKPTBiPTCyMlg2KM7:TR?= MkDoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyMUS3OVUoRjJ{MEG0O|U2RC:jPh?=
A549 NUXUXWtDS3m2b4TvfIlkcXS7IHHzd4F6 NX3qSmdkUUN3MDC9JFIvQTJizszN MojxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7Mke4NFEoRjJ6OUK3PFAyRC:jPh?=
A549 MoDMR5l1d3SxeHnjbZR6KGG|c3H5 Mn\jTWM2OCB;IEKuPVIh|ryP MlnJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5N{ewNFkoRjJ5N{e3NFA6RC:jPh?=
ZR75-30 M1mzd2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NX3tbFNOUUN3MDC9JFIvQTZizszN MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTFyMkG3OUc,OjlzMEKxO|U9N2F-
PC3 NG\yU3lEgXSxdH;4bYNqfHliYYPzZZk> NYPueJFbUUN3MDC9JFMvODNizszN NGXoUGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEO0NFkyOyd-MkizOFA6OTN:L3G+
MDA-MB-231 NXXRS2VvSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MYDJR|UxKD1iMz6wPEDPxE1? NHnYRpI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nkm5NVk{QCd-Mk[5PVE6Ozh:L3G+
A549 MnW5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmjsTWM2OCB;IEOuNUDPxE1? MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTFyMkG3OUc,OjlzMEKxO|U9N2F-
K562 M37RV2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mk\LS2k2OCB;IEOuNVYh|ryP NGKzR5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
MOLT4 MojBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYnHTVUxKD1iMz6xOkDPxE1? MmP4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
A549/ATCC M{DMdGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUTHTVUxKD1iMz6xOkDPxE1? MlTGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
RPMI8226 NYrKSlJ{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYewXHhbXEeLIE2gN{4yPiEQvF2= M4DVdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
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HOP62 MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkfMWGdKKD1iMz6xOkDPxE1? NUKzd5Q1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
NCI-H226 MlrYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWTUS2khRSB|LkG2JO69VQ>? NV\VdW4yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
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COLO205 M1jLV2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NW\v[VRTXEeLIE2gN{4yPiEQvF2= M{[wV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
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HCC2998 NXTufGhXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVPHTVUxKD1iMz6xOkDPxE1? MomxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
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786-0 MkPJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEn0eIlIUTVyIE2gN{4yPiEQvF2= NEPr[Vg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
A498 NHPZWppIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlnPWGdKKD1iMz6xOkDPxE1? NGSzSHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
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OVCAR3 M{ftWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVfHTVUxKD1iMz6xOkDPxE1? M1XxdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
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Caki1 NWnYNGQ3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUnHTVUxKD1iMz6xOkDPxE1? MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
SNB19 MmrrS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{XRWWdKPTBiPTCzMlE3KM7:TR?= NXPaW3F5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
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DU145 MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYLHTVUxKD1iMz6xOkDPxE1? MnqwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
OVCAR8 NH\QRYhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVTHTVUxKD1iMz6xOkDPxE1? NXTHRZJ7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
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MDA-MB-231 NXL3bVlXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mo\OWGdKKD1iMz6xOkDPxE1? NWDme|dQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
RXF393 M37Lb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2\UZ2dKPTBiPTCzMlE3KM7:TR?= MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
BT549 M2r5Smdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYTHTVUxKD1iMz6xOkDPxE1? M3zFT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
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DU145 MXPDfZRwfG:6aXPpeJkh[XO|YYm= M4nZU2dKPTBiPTCzMlE3KM7:TR?= Mn\zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
786-0 M4LVNGN6fG:2b4jpZ4l1gSCjc4PhfS=> MUnHTVUxKD1iMz6xOkDPxE1? MoPJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
BT549 M3n3[2N6fG:2b4jpZ4l1gSCjc4PhfS=> M1y1dGdKPTBiPTCzMlE3KM7:TR?= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
ACHN M{HjNmN6fG:2b4jpZ4l1gSCjc4PhfS=> M1LzPWdKPTBiPTCzMlE3KM7:TR?= MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
Caki1 NULMOGNDS3m2b4TvfIlkcXS7IHHzd4F6 M1\1bGdKPTBiPTCzMlE3KM7:TR?= NFXJR2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
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OVCAR5 MoXxRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MUTHTVUxKD1iMz6xOkDPxE1? NVfpUYR3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
RXF393 Mkj1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M2noUGdKPTBiPTCzMlE3KM7:TR?= MnLFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
SNB75 M4PBdWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MXPHTVUxKD1iMz6xOkDPxE1? NWTVV4tnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
OVCAR3 NXnac2ZpSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NIjDfIFIUTVyIE2gN{4yPiEQvF2= NWXXW|dJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
SNB19 MW\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NHnSN2ZIUTVyIE2gN{4yPiEQvF2= MmnrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
SK-MEL-5 M2jlcmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M37henRIUSB;IEOuNVYh|ryP NHnqWZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
OVCAR4 NFnabpZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MXzHTVUxKD1iMz6xOkDPxE1? MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
SK-MEL-2 NEDNZWZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NUS5fJY1XEeLIE2gN{4yPiEQvF2= NHzseG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
BT549 NF3nWJdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= Mny3S2k2OCB;IEOuNVYh|ryP MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
MOLT4 M3;ENmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NEfX[XFIUTVyIE2gN{4yPiEQvF2= M{TPWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
K562 NEDiTmRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NVzpXotYT0l3MDC9JFMvOTZizszN NIH1fmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
HCC2998 MWrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MV;HTVUxKD1iMz6xOkDPxE1? M365ZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
HCC2998 MnnIRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MXTUS2khRSB|LkG2JO69VQ>? MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
A549/ATCC MkX6RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NX3EO|BkT0l3MDC9JFMvOTZizszN NIC4OHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
DU145 MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MlyzS2k2OCB;IEOuNVYh|ryP MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
SR Mnq0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NVfzS2dxT0l3MDC9JFMvOTZizszN MnLWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
MCF7 NY[3Z2w2S3m2b4TvfIlkcXS7IHHzd4F6 M3PpbWlEPTBiPTCzMlE5KM7:TR?= NEftVZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEmyO|gxOSd-Mki5Nlc5ODF:L3G+
PC3 M3HBeGN6fG:2b4jpZ4l1gSCjc4PhfS=> MlXPTWM2OCB;IEOuNVgh|ryP NX;JN2hjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5Nlc5ODFpPkK4PVI4QDBzPD;hQi=>
MCF7 NG\qemFEgXSxdH;4bYNqfHliYYPzZZk> NETrbGJKSzVyIE2gN{4yQCEQvF2= NFW2XWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e3O|AxQSd-Mke3O|cxODl:L3G+
A549 Mo\yRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NWe0SXFCUUN3MDC9JFMvOTlizszN NHm5RZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe3PFk6PSd-MkW3O|g6QTV:L3G+
PC3 MWPDfZRwfG:6aXPpeJkh[XO|YYm= NYH4O3p[UUN3MDC9JFMvOjRizszN NVXEUm1xRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3O|cxODlpPkK3O|c4ODB7PD;hQi=>
HeLa NXnDfoIxTnWwY4Tpc44h[XO|YYm= MnnHTWM2OCB;IEOuN{DPxE1? MnP1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV{MkW3NFYoRjF3MkK1O|A3RC:jPh?=
HeLa MW\GeY5kfGmxbjDhd5NigQ>? MVXJR|UxKD1iMz6zJO69VQ>? M3nMOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MkK1O|A3Lz5zNUKyOVcxPjxxYU6=
LoVo NXHyT3ZwS3m2b4TvfIlkcXS7IHHzd4F6 NFrQXY1KSzVyIE2gN{4{KM7:TR?= NGGxcGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S1OFAyPyd-MkO0OVQxOTd:L3G+
A375 M1z5UWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M3;aW2lEPTBiPTCzMlM3KM7:TR?= MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZyMk[3OEc,Ojl4MEK2O|Q9N2F-
HT-29 MlH1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NXHafFVSUUN3MDC9JFMvOzdizszN Mo\hQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ7OUG5N|goRjJ4OUmxPVM5RC:jPh?=
FLT3 gene-deficient U937 NFnJbGtCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NWna[WhkT0l3MDC9JFMvPCEQvF2= M{TVbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{C4OFY5Lz5{MUewPFQ3QDxxYU6=
FLT3 negative U937 M2fUbmN6fG:2b4jpZ4l1gSCjc4PhfS=> NGDRbZBIUTVyIE2gN{41KM7:TR?= NHP4ZYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[xPFcxQSd-MkO2NVg4ODl:L3G+
U937 MmXqR5l1d3SxeHnjbZR6KGG|c3H5 M3Xi[GdKPTBiPTCzMlQh|ryP M3PPPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MEixNFI{Lz5{NkC4NVAzOzxxYU6=
A375P M33MdWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NFnwOlVIUTVyIE2gN{41KM7:TR?= NFHocYI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUS1PVE1PCd-Mkm0OVkyPDR:L3G+
ACHN MYnDfZRwfG:6aXPpeJkh[XO|YYm= NWGyUpY3UUN3MDC9JFMvPCEQvF2= NGL3cII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUWxO|kxQCd-Mkm1NVc6ODh:L3G+
ACHN M4HNUWN6fG:2b4jpZ4l1gSCjc4PhfS=> MlHITWM2OCB;IEOuOEDPxE1? MoPFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl{OUe2PFgoRjJ7Mkm3Olg5RC:jPh?=
HepG2 M4DubGZ2dmO2aX;uJIF{e2G7 NXzyeWI{UUN3MDC9JFMvPCEQvF2= NXmwWZFJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[wO|E5PjFpPkK2NFcyQDZzPD;hQi=>
A375P NF\BeJNEgXSxdH;4bYNqfHliYYPzZZk> NELYPIZIUTVyIE2gN{41KM7:TR?= NHT6OFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi3PFE6Oyd-MkS4O|gyQTN:L3G+
HepG2 M2XSSWN6fG:2b4jpZ4l1gSCjc4PhfS=> NFOxTWRKSzVyIE2gN{41PCEQvF2= M4XNR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUK3PFAyLz5{OEmyO|gxOTxxYU6=
HepG2 NXjzSndlS3m2b4TvfIlkcXS7IHHzd4F6 NGPvS2VKSzVyIE2gN{41PCEQvF2= NEf1bII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e3O|AxQSd-Mke3O|cxODl:L3G+
ACHN MknqR5l1d3SxeHnjbZR6KGG|c3H5 MoL1TWM2OCB;IEOuOUDPxE1? MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTd6NkSzOkc,Ojl5OE[0N|Y9N2F-
HepG2 NWnYVnlzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M33yd2lEPTBiPTCzMlUh|ryP MnfNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2NkKyOlUoRjJ3NE[yNlY2RC:jPh?=
HT-29 NG\tRpFEgXSxdH;4bYNqfHliYYPzZZk> NFrqUVJKSzVyIE2gN{43OSEQvF2= NHr4[nU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEiyOlgyPSd-MkS4NlY5OTV:L3G+
HT-29 M{Xmc2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NHy4e4JKSzVyIE2gN{43OSEQvF2= MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJzNki0PUc,OzB{MU[4OFk9N2F-
HT-29 NI\hNmJEgXSxdH;4bYNqfHliYYPzZZk> M1PUbWlEPTBiPTCzMlYyKM7:TR?= NIrySVA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC4OlI{QCd-MkWwPFYzOzh:L3G+
HT-29 MV7DfZRwfG:6aXPpeJkh[XO|YYm= MVrJR|UxKD1iMz62NUDPxE1? NWj0[XJ{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0OFA5PzlpPkK1OFQxQDd7PD;hQi=>
MCF7 NUOyfZZYSW62aXPhcoNmeiCjY4Tpeol1gSCjc4PhfS=> NUTpSI14UUN3MDC9JFMvPjRizszN MknJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NEm4OFEoRjJ7NUS5PFQyRC:jPh?=
Sf9 MkXOSpVv[3Srb36gZZN{[Xl? NXy2OIZzUUN3MDC9JFMvQCEQvF2= M2\nbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{C4OFY5Lz5{MUewPFQ3QDxxYU6=
Sf9 NIjmV4hHfW6ldHnvckBie3OjeR?= M4jj[GlEPTBiPTCzMlgh|ryP M{XFO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkG4O|A6Lz5{M{[xPFcxQTxxYU6=
Sf9 MlzFSpVv[3Srb36gZZN{[Xl? MYrJR|UxKD1iMz64JO69VQ>? NF\JS|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkC4NVAzOyd-Mk[wPFExOjN:L3G+
A2058 NVLPOYFKS3m2b4TvfIlkcXS7IHHzd4F6 MUfJR|UxKD1iMz64JO69VQ>? MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjdyOEm4O{c,OjJ5MEi5PFc9N2F-
NCI-H460 M{H4NGN6fG:2b4jpZ4l1gSCjc4PhfS=> NVGxVWZOUUN3MDC9JFMvQSEQvF2= NFW3e3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S1OFAyPyd-MkO0OVQxOTd:L3G+
SK-MEL-30 NUjXTFdES3m2b4TvfIlkcXS7IHHzd4F6 NFn4XWJKSzVyIE2gN{46KM7:TR?= MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR4MUiyO{c,Ojl2NkG4Nlc9N2F-
HT-29 MoDyRY51cWOjbnPldkBi[3Srdnn0fUBie3OjeR?= NVXGcJZuUUN3MDC9JFMvQTdizszN NH7qZ4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUW0PVg1OSd-Mkm1OFk5PDF:L3G+
SF268 Mn;2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlnGWGdKKD1iMz65PEDPxE1? NInKV5M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
SNB75 NVL6cm85T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV3xbGFZXEeLIE2gN{46QCEQvF2= M1nrNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
OVCAR3 MkHzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUHkS|FQXEeLIE2gN{46QCEQvF2= NVm5WmVFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
SNB19 NWDBNpZTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2G3[nRIUSB;IEOuPVgh|ryP M4\EN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
Hs 578T NX3GeIxiT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFzyZ|VVT0liPTCzMlk5KM7:TR?= NGP2bow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
TK10 M1HqZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUHHTVUxKD1iMz65PEDPxE1? MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
BT549 M1PzSGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4X2dHRIUSB;IEOuPVgh|ryP M1G5flxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
Caki1 NVHMfodISW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MYjUS2khRSB|Lkm4JO69VQ>? NFruWYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
TK10 M{\ZOGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MXXHTVUxKD1iMz65PEDPxE1? M{n6flxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
MDA-MB-435 NXPYSXZDSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NG\BZnhVT0liPTCzMlk5KM7:TR?= MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
HCT116 NUjTNZhVSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MlrHWGdKKD1iMz65PEDPxE1? MnL6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
MDA-MB-231 NVniS|NiSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NITaNXRVT0liPTCzMlk5KM7:TR?= MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
HepG2 MV;DfZRwfG:6aXPpeJkh[XO|YYm= NEX2eHZKSzVyIE2gOEDPxE1? MmexQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2NUSwNVcoRjJ|NEW0NFE4RC:jPh?=
HT-29 MV;DfZRwfG:6aXPpeJkh[XO|YYm= NHfZPW9KSzVyIE2gOEDPxE1? MnfxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2NUSwNVcoRjJ|NEW0NFE4RC:jPh?=
A549 NWnrVGlVS3m2b4TvfIlkcXS7IHHzd4F6 NGPSc3JKSzVyIE2gOEDPxE1? NUnwU3pxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0OVQxOTdpPkKzOFU1ODF5PD;hQi=>
HuH7 NWPucm1OS3m2b4TvfIlkcXS7IHHzd4F6 MlfSS2k2OCB;IESg{txO MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd{NkCyPEc,OjN5Mk[wNlg9N2F-
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MDA-MB-436 M1HwUGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 Mnz0TWM2OCB;IESuNkDPxE1? NI\QXFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUKwNlQxOyd-MkmyNFI1ODN:L3G+
MCF7 NWHkNmJZS3m2b4TvfIlkcXS7IHHzd4F6 MnT2TWM2OCB;IESuNlEh|ryP Mo[4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyNEOyOlgoRjJ5MESzNlY5RC:jPh?=
MCF7 M3\BcWN6fG:2b4jpZ4l1gSCjc4PhfS=> NYHV[HV{UUN3MDC9JFQvOjFizszN NF\RU3I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEO0NFkyOyd-MkizOFA6OTN:L3G+
LOXIMVI M4\uZmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NWG4RodtUUN3MDC9JFQvOjVizszN MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd5OEm5OUc,OjV5N{i5PVU9N2F-
OVCAR4 MV3DfZRwfG:6aXPpeJkh[XO|YYm= M{\zZnRIUSB;IESuN|Eh|ryP MonmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
WM1361 M2fVd2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MV7HTVUxKD1iND6zOFUh|ryP M3K1UlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUS4OVY{Lz5{MEG0PFU3OzxxYU6=
WM266.4 Mmq0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYHsdZZzT0l3MDC9JFQvPSEQvF2= MmnoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzOUmwPFcoRjJyMUm5NFg4RC:jPh?=
HepG2 NG\zWIVEgXSxdH;4bYNqfHliYYPzZZk> NUjZOnNIT0l3MDC9JFQvPSEQvF2= M2TMVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|N{K2NFI5Lz5{M{eyOlAzQDxxYU6=
A549 MWjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MnjUTWM2OCB;IESuOUDPxE1? MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ4MEW3PEc,OjN{NkC1O|g9N2F-
LS174T M4fPR2Z2dmO2aX;uJIF{e2G7 NWn6W3RKUUN3MDC9JFQvPTJizszN NX\BZ4JbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmyOlY6OzdpPkK5NlY3QTN5PD;hQi=>
8505C NXnmcpZzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MXzJR|UxKD1iND63JO69VQ>? NGW3Tnc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUCzNlA{OSd-MkmwN|IxOzF:L3G+
OVCAR8 M3P5fGN6fG:2b4jpZ4l1gSCjc4PhfS=> NET3cJNVT0liPTC0Mlc{KM7:TR?= NVHScWhxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1PVA2ODhpPkK2OVkxPTB6PD;hQi=>
MDA-MB-231 MWDDfZRwfG:6aXPpeJkh[XO|YYm= Mnf2TWM2OCB;IESuO|ch|ryP M1zQ[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNEO1OFc6Lz5{MESzOVQ4QTxxYU6=
B16-F1 M{L5NGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 Mo\OTWM2OCB;IESuPUDPxE1? NHTHS5A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOES3O|UxPSd-MUi0O|c2ODV:L3G+
WM164 NGPVTIxCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MkPTTWM2OCB;IESuPUDPxE1? NIfGU4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W2NVM6Oid-MUe1OlE{QTJ:L3G+
B16-F1 MoTIRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M4T2VmlEPTBiPTC0Mlkh|ryP NUnQZodpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwOVY2PDhpPkKwNFU3PTR6PD;hQi=>
MDA-MB-468 M3zJbWN6fG:2b4jpZ4l1gSCjc4PhfS=> MkP4TWM2OCB;IESuPUDPxE1? NWjxNG1pRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xOVk1QDNpPkK2NVU6PDh|PD;hQi=>
786-O M4X2dGN6fG:2b4jpZ4l1gSCjc4PhfS=> M1HrUmlEPTBiPTC0Mlkh|ryP M4XKVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUG3PVA5Lz5{OUWxO|kxQDxxYU6=
786-O MWrDfZRwfG:6aXPpeJkh[XO|YYm= NH;ldGhKSzVyIE2gOE46KM7:TR?= M2\pSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7Mkm3Olg5Lz5{OUK5O|Y5QDxxYU6=
WM266.4 NV7vcJl1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NY\0SWRCT0l3MDC9JFQvQTN|IN88US=> NFq5cnM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG0PFU3Oyd-MkCxOFg2PjN:L3G+
WM266.4 NXzsOHlpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHS5TJpKSzVyIE2gOUDPxE1? NVzqTIRURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNlM2PjBpPkG5N|I{PTZyPD;hQi=>
WM164 M4js[GFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MV;JR|UxKD1iNTFOwG0> NGCwTJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEC1OlU1QCd-MkCwOVY2PDh:L3G+
HepG2 M3zDd2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M2DvemlEPTBiPTC1JO69VQ>? NHTIeVU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K2NFU4QCd-MkOyOlA2Pzh:L3G+
HepG2 MUXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MYfJR|UxKD1iNTFOwG0> NITnTmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{mzNlA4OSd-MkO5N|IxPzF:L3G+
NCI-H23 MmXMS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M17PfXRIUSB;IEWuNFEh|ryP M1rTOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
NCI-H322M Mn;6S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWXUS2khRSB3LkCxJO69VQ>? MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
NCI-H460 NXztXI1RT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXnUS2khRSB3LkCxJO69VQ>? NX3ObWo3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
NCI-H522 NGL4XXJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYTUS2khRSB3LkCxJO69VQ>? MlXZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
HT-29 NIf0eXhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2Lke3RIUSB;IEWuNFEh|ryP MlG5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
CCRF-CEM MoexS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmLqWGdKKD1iNT6wNUDPxE1? NHz0Wnc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
SW620 M2XWc2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoHkWGdKKD1iNT6wNUDPxE1? Mm\uQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
HOP92 MoPlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NImyTIlVT0liPTC1MlAyKM7:TR?= NUDkcnZMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
786-0 Mlf0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M36wZ3RIUSB;IEWuNFEh|ryP NIHyR2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
MDA-MB-435 NXX2ZXl{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MorvWGdKKD1iNT6wNUDPxE1? Mnu4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
PC3 MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3LSVHRIUSB;IEWuNFEh|ryP M{L2[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
UACC257 M4\0eGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHfhVmZVT0liPTC1MlAyKM7:TR?= NEjSd3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
SKOV3 MlTHS5Jwf3SqIHnubIljcXSr