Etoposide (VP-16)

For research use only. Not for use in humans.

製品コードS1225 別名:VP-16213

Etoposide (VP-16)化学構造

CAS No. 33419-42-0

Etoposide (VP-16, VP-16213) is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. Etoposide induces autophagy, mitophagy and apoptosis.

サイズ 価格(税別)  
10mM (1mL in DMSO) JPY 17100
JPY 13600
JPY 48400
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バルク問合せ

文献中Selleckの製品使用例(190)

製品安全説明書

Antineoplastic and Immunosuppressive Antibiotics阻害剤の選択性比較

生物活性

製品説明 Etoposide (VP-16, VP-16213) is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. Etoposide induces autophagy, mitophagy and apoptosis.
ターゲット
Topo II [2]
(Cell-free assay)
体外試験

Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA, which induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. [1] Etoposide inhibits the growth of murine angiosarcoma cell line (ISOS-1) in a 5 days-period with IC50 of 0.25 μg/mL. Cell growth of normal murine microvascular endothelial cells (mECs) is less sensitive to Etoposide with IC50 of 10 μg/mL). [2] Etoposide treated for 6 hr inhibits colonies of tetraploid variant of the human leukemic lymphoblast line CCRF-CEM with IC50 of 0.6 μM. [3] Etoposide treated for 2 hr inhibits growth of human pancreatic cancer cell line Y1, Y3, Y5, Y19, YM. YS, and YT with IC50s of 300 μg/mL, 300 μg/mL, 300 μg/mL, 91 μg/mL, 0.68 μg/mL, 300 μg/mL, 300 μg/mL, and 260 μg/mL, respectively. [4] Etoposide exposed for 1 hr inhibits growth of human glioma cell lines CL5, G142, G152, G111, and G5 with IC50 of 8, 9, 9.8, 10, and 15.8 μg/mL respectively for 12 days. Under same condition, the IC90 value is attained in cell lines CL5, G152, G142, and G111 at 26, 27, 32, and 33 μg/mL. Etoposide inhibition of topoisomerase II is homogeneous for each cell. The average inhibition rates are 15%, 21.8%, 31.8%, 41.5%, and 49.5% for 1, 2, 4, 8, and 16 μg Etoposide, respectively. [5]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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HT-29 M{nEUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fsdlAvPS1{LkWg{txO NVPoVGxQPDkEoHlCpC=> NVjnOmNHUUN3ME23MlLDqMLzwrCxMlA1yqEQvF2= MmPqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5NE[3OlMoRjJ3N{S2O|Y{RC:jPh?=
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SMMC-7721 MX;GeY5kfGmxbjDBd5NigQ>? NVixVWxDPDBizszN MlLXOFghcA>? MmfVSG1UVw>? MnLIbY5lfWOnczFOt2gzSVhiZn;jbUBnd3KvYYTpc44> M123NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NUS0N|YyLz5{NUW0OFM3OTxxYU6=
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MCF-7 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX63NuKhcA>? MW\JR|UxRTFyLkpCpOKyyqB{LkJCpO69VQ>? MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR6NkKxPUc,OjV2OE[yNVk9N2F-
Jurkat MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3ON3U4OsLiaB?= NIrUc4RKSzVyPUGuNuKhyrIEoEGuOeKh|ryP Moq4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2OE[yNVkoRjJ3NEi2NlE6RC:jPh?=
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MCF7  M122Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDnT4k2NTFyMDFOwG0> MYC3JIQ> MUTpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> NUnjRZhERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0O|I3OTlpPkK1OFczPjF7PD;hQi=>
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K/VP.5 NIfHOnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\H[GU4OsLiaB?= NE\oN4NKSzVyPUSuPeKh|ryP NWLMVYZkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyPFI3PTNpPkK1NlgzPjV|PD;hQi=>
SH-EP  M3nwO2Z2dmO2aX;uJGF{e2G7 NGXCdWMzOMLizsznM41t MWSyOOKhcA>? NX\wXVhCcW6lcnXhd4V{KHSqZTDlfJBz\XO|aX;uJI9nKGWwZH;n[Y5wfXNiRFXQVC=> NWXmZYViRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyOlE6QDFpPkK1NlYyQThzPD;hQi=>
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CAL27 MoTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHYflkzPMLiaB?= NV;YZ3VYUUN3ME21Nk4yyqEEsdMgNU4xQcLizszN MonMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{MkC3NlkoRjJ3MkKwO|I6RC:jPh?=
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HT1080 NXm2VnpLTnWwY4Tpc44hSXO|YYm= M4mxfVAvODByMT2xNFAh|ryP M160blEuOjRiaB?= M4nJO2ROW00EoB?= MnnwbY5lfWOnczDwMZA2Oyi|ZYKxOUkhcW5iYn;0bEB1cW2nLTDhcoQh[2:wY3XueJJifGmxbj3k[ZBmdmSnboSgcYFvdmW{ NHq3UmI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC3PFA3PCd-MkWwO|gxPjR:L3G+
HT1080 NYDLSWx[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LnUlAvODByMT2xNFAh|ryP Mm\ENlQhcA>? NYTFbXhrTE2VT9Mg MUPjZZV{\XNiYX6gbY5kemWjc3WgbY4hfGinIH71cYJmeiCxZjDj[YxteyCrbjDHNk9ONCC5aHns[UBl\WO{ZXHzbY5oKFNiYX7kJGcyKHCqYYPlJINmdGy| M2XZdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEe4NFY1Lz5{NUC3PFA3PDxxYU6=
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DOHH-2 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3ybGozPCCq MkjtTWM2OO,:nkGwNEDPxE1? NVfT[IV5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwOFgzOzZpPkK1NFQ5OjN4PD;hQi=>
DOHH-2 Mn3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzyNI41QCCq MY\JR|UxRTF7LkpCpO69VQ>? NGrDVmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC0PFI{Pid-MkWwOFgzOzZ:L3G+
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HuT-78 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13DWFI1KGh? NEK3[2tKSzVyPUmuN:Kh|ryP Ml[1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyNEiyN|YoRjJ3MES4NlM3RC:jPh?=
HuT-78 NFvEXJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDwOFghcA>? NYfZN213UUN3ME20MlPDqM7:TR?= M{TSNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MES4NlM3Lz5{NUC0PFI{PjxxYU6=
HuT-78 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PyVVczKGh? MkHYTWM2OD12LkNCpO69VQ>? MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTB2OEKzOkc,OjVyNEiyN|Y9N2F-
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RPMI-8226 M3LIeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrUWXVJPDhiaB?= MVPJR|UxRTlzLkJCpO69VQ>? NFfKdpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC0PFI{Pid-MkWwOFgzOzZ:L3G+
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U-266 NV;ZRppmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXG4Umt{OjRiaB?= M2jCVWlEPTB;OE[uNuKh|ryP MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTB2OEKzOkc,OjVyNEiyN|Y9N2F-
U-266 NVzmfWJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;LbVU1QCCq NFzjUpZKSzVyPU[4MlTDqM7:TR?= NEDPZVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC0PFI{Pid-MkWwOFgzOzZ:L3G+
U-266 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWWxSI1TPzJiaB?= MUPJR|UxRTJ5LkVCpO69VQ>? MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTB2OEKzOkc,OjVyNEiyN|Y9N2F-
Kelly NFTmSoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DmS|AuOTBizszN MkLLO|LDqGh? MWTJR|UxRTFwNUG4xsDPxE1? Mn22QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyMEi5NFAoRjJ3MEC4PVAxRC:jPh?=
SH-SY5Y  NHLnSpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWqwMVExKM7:TR?= MXS3NuKhcA>? M2PEOmlEPTB;MD63OVTDqM7:TdMg MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTByOEmwNEc,OjVyMEi5NFA9N2F-
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SK-N-DZ MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTmNE0yOCEQvF2= M1\ybFczyqCq MX\JR|UxRTVwNEi1xsDPxE1? NHe0OVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUCwPFkxOCd-MkWwNFg6ODB:L3G+
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HL-60  MoK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF74W5M4OsLiaB?= MVrJR|UxRTBwMUNihKXPxE1? NXPVeGxYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5PVMxOTRpPkK0PVk{ODF2PD;hQi=>
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HL60/MX2 M2HCfmN6fG:2b4jpZ4l1gSCjc4PhfS=> MkDvO|IhcHK| MWnDfZRwfG:6aXPpeJkh[WejaX7zeEBucXSxeHHueJJwdmVvcnXzbZN1[W62IHj1cYFvKEiONkCvUXgzKGOnbHzzJIFnfGW{IEeyJIhzeyxiSVO1NEA:KDR6LkWg{txONg>? NEHDbWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEWwO|M3QCd-MUi1NFc{Pjh:L3G+
HL60 MVLDfZRwfG:6aXPpeJkh[XO|YYm= M{nEd|czKGi{cx?= MmP0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGw3OCClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNE4zKM7:TT6= NEiybpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEWwO|Q4Oid-MUi1NFc1PzJ:L3G+
HL60 MoO5RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NU\WZ|lzPDhiaILz NH:yOpVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjMOlAh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuN|E2KM7:TT6= MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDVzM{m3OEc,OTh3MUO5O|Q9N2F-
K562 MYTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M3jVZVQ5KGi{cx?= Mn7pRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCNNU[yJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzLkK3JO69VS5? NFG5[YM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEWxOFk4Oid-MUi1NVQ6PzJ:L3G+
KB NVqxbYNoSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NFPsSGE1QCCqcoO= MVfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEuEIHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjR{IN88UU4> MoLFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3MUS5O|IoRjF6NUG0PVczRC:jPh?=
L02 NHfsfndCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= Mm\GOFghcHK| NFXiSGFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFywNkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUOg{txONg>? NYPyZoc4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1NVQ6PzJpPkG4OVE1QTd{PD;hQi=>
DU145 ATCC HTB 81 Mkm5R5l1d3SxeHnjbZR6KGG|c3H5 MXG3NkBpenN? NV;NWZZJS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTFVzNEWgRXRESyCKVFKgPFEh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGuOUDPxE1w NXrRR4hmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1OVg1QTBpPkG4OVU5PDlyPD;hQi=>
K562 ATCC CCL 243 MXHDfZRwfG:6aXPpeJkh[XO|YYm= NWjmeWlxPzJiaILz MVTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKEGWQ1OgR2NNKDJ2MzDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPC57IN88UU4> M1r3XVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NUW4OFkxLz5zOEW1PFQ6ODxxYU6=
MCF7 ATCC HTB 22 NXjnXYVkS3m2b4TvfIlkcXS7IHHzd4F6 MVK3NkBpenN? M3jGVWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiQWTDR{BJXEJiMkKgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF{LkKg{txONg>? M{DaPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NUW4OFkxLz5zOEW1PFQ6ODxxYU6=
U251 RCB 0641 MmTER5l1d3SxeHnjbZR6KGG|c3H5 M4nLXlczKGi{cx?= NYe3Nmg2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXTJ3MTDSR2IhODZ2MTDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC53IN88UU4> NUTxdmJZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1OVg1QTBpPkG4OVU5PDlyPD;hQi=>
3LL CRL 1642 MlHFR5l1d3SxeHnjbZR6KGG|c3H5 NVWwfItUPDhiaILz NH;qV5JEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UA{VExiQ2LMJFE3PDJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFQh|ryPLh?= NEm5S4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW1PFQ6OCd-MUi1OVg1QTB:L3G+
L1210 ATCC CCL 219 M4XnZWN6fG:2b4jpZ4l1gSCjc4PhfS=> MUW0PEBpenN? NVfuRW9RS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhVDF{MUCgRXRESyCFQ1ygNlE6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlUh|ryPLh?= NIW1XGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW1PFQ6OCd-MUi1OVg1QTB:L3G+
SK-Hep1 Ml7ZR5l1d3SxeHnjbZR6KGG|c3H5 MoP1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2suUGWyMTDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0PU43KM7:TT6= NXjGO5ZTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi2N|c3QDhpPkG4OlM4Pjh6PD;hQi=>
HL60 NV21ZZBRS3m2b4TvfIlkcXS7IHHzd4F6 Mlz1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGw3OCClZXzsd{BjgSCVUlKgZZN{[XluIFnDOVAhRSByLkKg{txONg>? NWHZcFlrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi2OVE4PzFpPkG4OlUyPzdzPD;hQi=>
A549 MnnYR5l1d3SxeHnjbZR6KGG|c3H5 M3\mOWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJINmdGxiZ4Lve5RpKGK7IGPSRkBu\XSqb3SsJGlEPTBiPTC5Mlk5KM7:TT6= NX71bVhWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi3PFI3PjhpPkG4O|gzPjZ6PD;hQi=>
KB NInwWotEgXSxdH;4bYNqfHliYYPzZZk> NH;NZVBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMSiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[gZ4VtdCCpcn;3eIgh[nliU2LCJI1mfGixZDygTWM2OCB;IEG0MlIh|ryPLh?= NUHuXlIyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi3PFI3PjhpPkG4O|gzPjZ6PD;hQi=>
A549 MWLDfZRwfG:6aXPpeJkh[XO|YYm= M{\MOlczKGi{cx?= M1LoOGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFgvOzdizszNMi=> NXPWPW9SRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi4OFQ1OjJpPkG4PFQ1PDJ{PD;hQi=>
KB NVzQOmNoS3m2b4TvfIlkcXS7IHHzd4F6 NYjhTW9yPzJiaILz MXHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLRkBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMT6yOUDPxE1w NVnJWJFURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi4OFQ1OjJpPkG4PFQ1PDJ{PD;hQi=>
AGS NHLJO|dEgXSxdH;4bYNqfHliYYPzZZk> MUCzJIRigXN? NVf0VWxKS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSUeVIHPlcIx{KGGodHXyJFMh\GG7czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjN4IN88UU4> MlPQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyMUOwO|QoRjF7MEGzNFc1RC:jPh?=
HL-60 NV7CVVdiS3m2b4TvfIlkcXS7IHHzd4F6 NUT2c4tSOyCmYYnz NXXoSYhQS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUExvNkCgZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwODFOwG0v MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTBzM{C3OEc,OTlyMUOwO|Q9N2F-
J82 MWrDfZRwfG:6aXPpeJkh[XO|YYm= NXHuOoZ[OyCmYYnz NYTibI5vS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUjh{IHPlcIx{KGGodHXyJFMh\GG7czDifUBOXFRiYYPzZZktKEmFNUCgQUAzNjhizszNMi=> MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTBzM{C3OEc,OTlyMUOwO|Q9N2F-
MRC5 M1r2UGN6fG:2b4jpZ4l1gSCjc4PhfS=> NIrvW|Q{KGSjeYO= MXrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNVmM2KGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzMlkh|ryPLh?= MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTBzM{C3OEc,OTlyMUOwO|Q9N2F-
SK-MES-1 MlLUR5l1d3SxeHnjbZR6KGG|c3H5 MXyzJIRigXN? NIOxOYREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUUy2PRWOtNUBk\WyuczDh[pRmeiB|IHThfZMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMj61JO69VS5? MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTBzM{C3OEc,OTlyMUOwO|Q9N2F-
A375 MnvwR5l1d3SxeHnjbZR6KGG|c3H5 MXfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBN|c2KGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDNwOUKg{txONg>? M{DNdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEO2OVg1Lz5zOUCzOlU5PDxxYU6=
A549 MkTRR5l1d3SxeHnjbZR6KGG|c3H5 MX;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDlwNUGg{txONg>? M{nRPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEO2OVg1Lz5zOUCzOlU5PDxxYU6=
HL60 M4foeGN6fG:2b4jpZ4l1gSCjc4PhfS=> MmXRR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGw3OCClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzLkizJO69VS5? NV7IcJhyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwN|Y2QDRpPkG5NFM3PTh2PD;hQi=>
THP1 NV\WOnUxS3m2b4TvfIlkcXS7IHHzd4F6 NYLrcFZwS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXEiSMTDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyMlE3KM7:TT6= MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB|NkW4OEc,OTlyM{[1PFQ9N2F-
A549 NVzYdpRYS3m2b4TvfIlkcXS7IHHzd4F6 MnPPO|IhcHK| MWnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC1Mlkh|ryPLh?= MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB3M{WxOEc,OTlyNUO1NVQ9N2F-
HL-60 M4LDUWN6fG:2b4jpZ4l1gSCjc4PhfS=> MkiyO|IhcHK| MX3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIUE03OCClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNE4zPSEQvF2u MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB3M{WxOEc,OTlyNUO1NVQ9N2F-
U937 NEnmfIxEgXSxdH;4bYNqfHliYYPzZZk> NHSxeHU4OiCqcoO= NYTDUW5[S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXTl|NzDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC57MjFOwG0v MkfFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyNUO1NVQoRjF7MEWzOVE1RC:jPh?=
ACHN M13MWmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NHTLb5I6PiCqcoO= MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEGFSF6gZ4VtdHNiYX\0[ZIhQTZiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJwMUWg{txONg>? NWrPVXF5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwOVM4PjdpPkG5NFU{PzZ5PD;hQi=>
CCRF-CEM MWHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NHW4VYQ6PiCqcoO= MnT3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCFQ2LGMWNGVSClZXzsd{Bi\nSncjC5OkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNU4zKM7:TT6= MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB3M{e2O{c,OTlyNUO3Olc9N2F-
CCRF-SB MVXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MlH3PVYhcHK| NWnob4NlSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDDR3JHNVOEIHPlcIx{KGGodHXyJFk3KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjFizszNMi=> NVfHTnUxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwOVM4PjdpPkG5NFU{PzZ5PD;hQi=>
HeLa M334WWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NXHLNo1tQTZiaILz NEPyS3lCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjlUIEh[2WubIOgZYZ1\XJiOU[gbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOg{txONg>? M2HxO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEWzO|Y4Lz5zOUC1N|c3PzxxYU6=
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lung cancer cells MoqyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NH\0eWU4OiCqcoO= Mn;CS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gcJVv\yClYX7j[ZIh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IIP1cIZwemixZHHtbY5mKEJiYYPzZZktKEeLNUCgQUAyNjNizszNMi=> NH;5NnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi4OFA5QSd-MkC4PFQxQDl:L3G+
HCT15 NV7Od256SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MoO0OFghcHK| NHLib4lCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFE2KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHHzd4F6NCCLQ{WwJF0hOS54IN88UU4> MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODl|OUWxOkc,OjB7M{m1NVY9N2F-
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HL60 M2\YUGN6fG:2b4jpZ4l1gSCjc4PhfS=> MUi3NkBpenN? MWTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIFnfGW{IEeyJIhzeyxiSVO1NEA:KDBwNEi2JO69VS5? NGPLcIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEm2NVc3Pyd-MkC5OlE4Pjd:L3G+
HL60/MX2 M2nN[GN6fG:2b4jpZ4l1gSCjc4PhfS=> NULrOHgzPzJiaILz NWfuW5o6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEx4MD;NXFIh[2WubIOgZYZ1\XJiN{KgbJJ{NCCLQ{WwJF0hPDhwNTFOwG0v NGXGNZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEm2NVc3Pyd-MkC5OlE4Pjd:L3G+
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NCI60 NILJZ3BIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnfLS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUmNKPjBiY3XscJMh[nliU1LSJIF{e2G7LDDHTVUxKD1iM{iuPVA1PSEQvF2u NXjnTm5HRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwN|U{OzRpPkKxNFM2OzN2PD;hQi=>
502713 MWfBcpRq[2GwY3XyJIF{e2G7 NV7lenVLPDhiaILz MXHBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iNUCyO|E{KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCwMlEh|ryPLh?= MmrBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyN{S0OFQoRjJzMEe0OFQ1RC:jPh?=
A549 NEXxSlhCdnSrY3HuZ4VzKGG|c3H5 NX7WPVlKPDhiaILz M4Xie2FvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCzMlA5KM7:TT6= Mn\hQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyN{S0OFQoRjJzMEe0OFQ1RC:jPh?=
DU145 NVSzbph{SW62aXPhcoNmeiCjc4PhfS=> NELQe|Q1QCCqcoO= MVvBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iRGWxOFUh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygTWM2OCB;IEOuO{DPxE1w MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB5NES0OEc,OjFyN{S0OFQ9N2F-
HCT15 NHe2TGNCdnSrY3HuZ4VzKGG|c3H5 M3PPNlQ5KGi{cx?= MYHBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVUh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygTWM2OCB;IECuPUDPxE1w NX\XN2VDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwO|Q1PDRpPkKxNFc1PDR2PD;hQi=>
Hep2 MlnYRY51cWOjbnPldkBie3OjeR?= NUDPRpBqPDhiaILz NWn5dGg1SW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJGhmeDJiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFAvQSEQvF2u MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB5NES0OEc,OjFyN{S0OFQ9N2F-
IMR32 NIrHbIlCdnSrY3HuZ4VzKGG|c3H5 M1;aZlQ5KGi{cx?= M4jtN2FvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDJUXI{OiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gOk4{KM7:TT6= M{K0[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMEe0OFQ1Lz5{MUC3OFQ1PDxxYU6=
PC3 NFjWe4hCdnSrY3HuZ4VzKGG|c3H5 MkjYOFghcHK| NEHRfGZCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gVGM{KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCyMlYh|ryPLh?= NXzSPW9lRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwO|Q1PDRpPkKxNFc1PDR2PD;hQi=>
HT-29 Ml;yR5l1d3SxeHnjbZR6KGG|c3H5 MmLqO|IhcHK| MWjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBIUTVyIE2gN|EvPjJizszNMi=> NEGzeYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUGxOVIyOCd-MkGxNVUzOTB:L3G+
K562 NHPMU2NEgXSxdH;4bYNqfHliYYPzZZk> Mmf0O|IhcHK| NWXYS|NwS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCJSUWwJF0hOTJwNUmg{txONg>? MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTFzNUKxNEc,OjFzMUWyNVA9N2F-
MCF7 M4fydGN6fG:2b4jpZ4l1gSCjc4PhfS=> M1LIXFczKGi{cx?= MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGdKPTBiPTCxPU46PSEQvF2u NVLMUJdwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGxNVUzOTBpPkKxNVE2OjFyPD;hQi=>
PC3 MVzDfZRwfG:6aXPpeJkh[XO|YYm= NGnoSmk4OiCqcoO= MVPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygS2k2OCB;IECuOlMh|ryPLh?= MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTFzNUKxNEc,OjFzMUWyNVA9N2F-
PC3 MknaR5l1d3SxeHnjbZR6KGG|c3H5 MWq3NkBpenN? NFqyNllEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhXEeLIE2gN{46QCEQvF2u NVnH[HFsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGxNVUzOTBpPkKxNVE2OjFyPD;hQi=>
DU145 M1HwSWN6fG:2b4jpZ4l1gSCjc4PhfS=> MVvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzLkS0JO69VS5? MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTFzNUK0Okc,OjFzMUWyOFY9N2F-
HCT15 Ml\0R5l1d3SxeHnjbZR6KGG|c3H5 NHLCUnNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzNTDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyMlA{KM7:TT6= NVz6OWx4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGxNVUzPDZpPkKxNVE2OjR4PD;hQi=>
K562 MVTDfZRwfG:6aXPpeJkh[XO|YYm= NIHwW4NEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGuNlEh|ryPLh?= M2fXXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMUG1NlQ3Lz5{MUGxOVI1PjxxYU6=
MCF7 M1LxNGN6fG:2b4jpZ4l1gSCjc4PhfS=> MnnpR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzLkm4JO69VS5? NHPuO|E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUGxOVI1Pid-MkGxNVUzPDZ:L3G+
95-D MoDOR5l1d3SxeHnjbZR6KGG|c3H5 M2W4W|czKGi{cx?= NYLyTZBpS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hQTVvRDDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5yMkCyJO69VS5? MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTF2NUGzPUc,OjFzNEWxN|k9N2F-
A549 Mn;jR5l1d3SxeHnjbZR6KGG|c3H5 NVrkeHN5PzJiaILz NUP0dpdVS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5yMEK1OkDPxE1w NUDwZ5lKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGxOFUyOzlpPkKxNVQ2OTN7PD;hQi=>
KB NUnrRZNGS3m2b4TvfIlkcXS7IHHzd4F6 MmjxO|IhcHK| M{jIemN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGtDKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlAxPDZzIN88UU4> MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTF2NUGzPUc,OjFzNEWxN|k9N2F-
KB/VCR NUTVSplFS3m2b4TvfIlkcXS7IHHzd4F6 Mn3MO|IhcHK| M2L5UWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGtDN1[FUjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5yOEO0JO69VS5? M4\lV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMUS1NVM6Lz5{MUG0OVE{QTxxYU6=
HepG2 NGrk[3NEgXSxdH;4bYNqfHliYYPzZZk> MXXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzNT64JO69VS5? M4r2WVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMUe0OFA5Lz5{MUG3OFQxQDxxYU6=
MOLT3 NVzTV4FiS3m2b4TvfIlkcXS7IHHzd4F6 MnfUR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUW9NXDNiY3XscJMh[nliWGTUJIF{e2G7LDDJR|UxKD1iMD6wN{DPxE1w M3ewUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMUe0OFA5Lz5{MUG3OFQxQDxxYU6=
A549 NVnQcFlXS3m2b4TvfIlkcXS7IHHzd4F6 MUnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIJ6KFOUQjDhd5NigSxiSVO1NEA:KDFwOEWg{txONg>? NUDNR49MRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGxPFIzPThpPkKxNVgzOjV6PD;hQi=>
SK-MEL-2 NGjqZ4hEgXSxdH;4bYNqfHliYYPzZZk> MUjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT{1OTUxvMjDj[YxteyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCxMlE4KM7:TT6= MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTF6MkK1PEc,OjFzOEKyOVg9N2F-
SKOV3 NFi3emREgXSxdH;4bYNqfHliYYPzZZk> MWrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT29XOyClZXzsd{BjgSCVUlKgZZN{[XluIFnDOVAhRSBzLkixJO69VS5? NXHscXBYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGxPFIzPThpPkKxNVgzOjV6PD;hQi=>
XF498 NILHZYJEgXSxdH;4bYNqfHliYYPzZZk> M4HkVGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHhHPDl6IHPlcIx{KGK7IGPSRkBie3OjeTygTWM2OCB;IEGuO|Ih|ryPLh?= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTF6MkK1PEc,OjFzOEKyOVg9N2F-
A549 NIHMcVhEgXSxdH;4bYNqfHliYYPzZZk> NH:2[oI{KGSjeYO= MkfLR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEOg[IF6eyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyNU41KM7:TT6= MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTJ5N{[1OUc,OjF{N{e2OVU9N2F-
HCT116 M2XuU2N6fG:2b4jpZ4l1gSCjc4PhfS=> NHroWoc{KGSjeYO= MXrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjCzJIRigXNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVMvPSEQvF2u MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTJ5N{[1OUc,OjF{N{e2OVU9N2F-
HepG2 Mn;hR5l1d3SxeHnjbZR6KGG|c3H5 MnK0N{Bl[Xm| NYq4eIN1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA{KGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPC57IN88UU4> MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTJ5N{[1OUc,OjF{N{e2OVU9N2F-
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HepG2 NGW2S5NEgXSxdH;4bYNqfHliYYPzZZk> MUW5OkBpenN? NHfwTmREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA6PiCqcoOsJGlEPTBiPTC0JO69VS5? MnXnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{N{[3O|UoRjJ{Mke2O|c2RC:jPh?=
MT4 M3rYU2N6fG:2b4jpZ4l1gSCjc4PhfS=> NWjvfZAyQTZiaILz MWrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNWFQh[2WubIOgZYZ1\XJiOU[gbJJ{NCCLQ{WwJF0hOC5yOTFOwG0v MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ5Nke3OUc,OjJ{N{[3O|U9N2F-
DU145 M1e5SmN6fG:2b4jpZ4l1gSCjc4PhfS=> Mn;3NkBl[Xm| MWHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bi\nSncjCyJIRigXNuIFnDOVAhRSB{Lkm0JO69VS5? NFzFXZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOxPFE3PCd-MkKzNVgyPjR:L3G+
HCT15 M3Sxe2N6fG:2b4jpZ4l1gSCjc4PhfS=> MYiyJIRigXN? NHjGPZBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzNTDj[YxteyCjZoTldkAzKGSjeYOsJGlEPTBiPTCxMlM{KM7:TT6= MnX5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|MUixOlQoRjJ{M{G4NVY1RC:jPh?=
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K562 NVXSUWJLS3m2b4TvfIlkcXS7IHHzd4F6 NH\6NHczKGSjeYO= M2[xd2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgNkBl[Xm|LDDJR|UxKD1iMj6wPUDPxE1w MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjNzOEG2OEc,OjJ|MUixOlQ9N2F-
MCF7 Mmr5R5l1d3SxeHnjbZR6KGG|c3H5 MX6yJIRigXN? NV3OdVZlS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkAzKGSjeYOsJGlEPTBiPTCzMlI2KM7:TT6= NUjoTWJURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzNVgyPjRpPkKyN|E5OTZ2PD;hQi=>
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HL60 M1LkUmN6fG:2b4jpZ4l1gSCjc4PhfS=> MknINkBl[Xm| MYDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIFnfGW{IEKg[IF6eyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxMlg{KM7:TT6= MmHWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|MkW4PVcoRjJ{M{K1PFk4RC:jPh?=
Jurkat NVr4fFhzS3m2b4TvfIlkcXS7IHHzd4F6 MYCyJIRigXN? MlnKR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTpVzc2G2IHPlcIx{KGGodHXyJFIh\GG7czDifUBOXFRiYYPzZZktKEmFNUCgQUA2NjN3IN88UU4> M1fBfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{K1PFk4Lz5{MkOyOVg6PzxxYU6=
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Hep3B M3;OWWN6fG:2b4jpZ4l1gSCjc4PhfS=> NIXYclI4OiCqcoO= MUjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZA{SiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOk44KM7:TT6= MnnLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|NEKxNFEoRjJ{M{SyNVAyRC:jPh?=
U87 MVPDfZRwfG:6aXPpeJkh[XO|YYm= NUT0elM1PzJiaILz MUfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDVPFch[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGyMlQh|ryPLh?= MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN2MkGwNUc,OjJ|NEKxNFE9N2F-
A2780 NFzvdmhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGLPWGs1QCCqcoO= NEDwRZJIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBCOjd6MDDj[YxteyCjZoTldkA1QCCqcoOgZpkhe3WuZn;ybI9l[W2rbnWgRkBie3OjeTygS2k2OCB;IEGuN|Eh|ryPLh?= NFLBXFY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkO2OFc1Pid-MkKzOlQ4PDZ:L3G+
A549 MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4PGUlQ5KGi{cx?= NHXZO|dIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFQ5KGi{czDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7LDDHTVUxKD1iMz6wPEDPxE1w MonzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|NkS3OFYoRjJ{M{[0O|Q3RC:jPh?=
COLO205 NULyNYJnT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlXUOFghcHK| NGfleJhIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBEV0yRMkC1JINmdGy|IHHmeIVzKDR6IHjyd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGG|c3H5MEBIUTVyIE2gNE4yOyEQvF2u MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN4NEe0Okc,OjJ|NkS3OFY9N2F-
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HOP62 M1LXbGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mn7xOFghcHK| NX75eZBPT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUE:SNkKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO|YYmsJGdKPTBiPTCwMlgh|ryPLh?= MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN4NEe0Okc,OjJ|NkS3OFY9N2F-
KB MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2Szb|Q5KGi{cx?= NYXKWJVlT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hU0JiY3XscJMh[W[2ZYKgOFghcHK|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XluIFfJOVAhRSByLkOxJO69VS5? NY\KUlZTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzOlQ4PDZpPkKyN|Y1PzR4PD;hQi=>
MCF7 MXrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHn2PYU1QCCqcoO= NHXmSYRIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFQ5KGi{czDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7LDDHTVUxKD1iMj6xNUDPxE1w MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN4NEe0Okc,OjJ|NkS3OFY9N2F-
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DU145 M37zZ2N6fG:2b4jpZ4l1gSCjc4PhfS=> NGLCUlIzKGSjeYO= M{focWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGRWOTR3IHPlcIx{KGGodHXyJFIh\GG7czDifUBk\WyuIHPveY51cW6pIHvpeE05KGGwYXz5d4l{NCCLQ{WwJF0hOS5{MTFOwG0v NUnxXFZwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1NFM3PTZpPkKyOVA{PjV4PD;hQi=>
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HEK293 M131[mN6fG:2b4jpZ4l1gSCjc4PhfS=> MoHLNkBl[Xm| NF;pW|hEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJTUt{OUOgZ4VtdHNiYX\0[ZIhOiCmYYnzJIJ6KGOnbHygZ492dnSrbnegb4l1NThiYX7hcJl{cXNuIFnDOVAhRSBzLkKxJO69VS5? NES2bm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkWwN|Y2Pid-MkK1NFM3PTZ:L3G+
T47D NHH1WmtEgXSxdH;4bYNqfHliYYPzZZk> MoXlNkBl[Xm| M3\UZWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHQ1P0RiY3XscJMh[W[2ZYKgNkBl[Xm|IHL5JINmdGxiY3;1cpRqdmdia3n0MVgh[W6jbInzbZMtKEmFNUCgQUAzNjN7IN88UU4> NGXXUYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkWwN|Y2Pid-MkK1NFM3PTZ:L3G+
MCF7 MWrDfZRwfG:6aXPpeJkh[XO|YYm= NFq4NYo1QCCqcoO= MmriR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNE41QCEQvF2u M3vUSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NU[0N|g{Lz5{MkW2OFM5OzxxYU6=
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U87 MVnDfZRwfG:6aXPpeJkh[XO|YYm= MX[0PEBpenN? MYPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDVPFch[2WubIOg[ZhxemW|c3nu[{B4cWymLYT5dIUheDV|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLk[yJO69VS5? NYW5bmNiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1OlQ{QDNpPkKyOVY1Ozh|PD;hQi=>
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