CHIR-99021 (CT99021)

For research use only. Not for use in humans.

製品コードS1263

CHIR-99021 (CT99021)化学構造

CAS No. 252917-06-9

CHIR-99021 (CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs. CHIR99021 functions as a Wnt/β-catenin activator and induces autophagy.

サイズ 価格(税別)  
JPY 16900
JPY 30200
JPY 96600
JPY 163000
最寄りの販売代理店を探す

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バルク問合せ

文献中Selleckの製品使用例(555)

製品安全説明書

GSK-3阻害剤の選択性比較

生物活性

製品説明 CHIR-99021 (CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs. CHIR99021 functions as a Wnt/β-catenin activator and induces autophagy.
ターゲット
GSK-3β [1]
(Cell-free assay)
GSK-3α [1]
(Cell-free assay)
6.7 nM 10 nM
体外試験

CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. Furthermore, CHIR-99021 shows only weak binding to a panel of 22 pharmacologically relevant receptors and little inhibitory activity against a panel of 23 nonkinase enzymes. CHIR-99021 induces the activation of glycogen synthase (GS) in insulin receptor-expressing CHO-IR cells with EC50 of 0.763 μM[1].

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
LOUCY MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTF6Mj62PFgh|ryP M1vpUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
SN12C Mm[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrmWGRKSzVyPUG4Nk45OjlizszN MkTMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
A427 NWr1PFJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml20TWM2OD1zOESuOlMyKM7:TR?= M1fBZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
DOK NXXXW2hOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnPO3B3UUN3ME2xPFQvPjR|IN88US=> MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
MDA-MB-415 MlPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4X1XWlEPTB;MUi0MlY2OSEQvF2= NHTVdos9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
MRK-nu-1 MkW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7TdphkUUN3ME2xPFQvQTd{IN88US=> NUTJXG5tRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
LB2241-RCC NUTwc5JKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPXUYg2UUN3ME2xPFUvOTR3IN88US=> MkHFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
NCI-H1563 MkDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXLbIJKSzVyPUG4OU4zODlizszN NYTJR2hnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
MDA-MB-453 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTF6Nj65OFEh|ryP NUjHZ5E1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
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HCE-4 M3rGZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3H3ZmlEPTB;MUmwMlk6OiEQvF2= NYSyc5RMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
A2780 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTF7Mj64PVEh|ryP M3vPfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
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KOSC-2 NH3kXIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXwTWM2OD1zOUWuPFE5KM7:TR?= MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
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22RV1 MoDCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;Fb2lEPTB;MUm3MlQzPCEQvF2= NYjJ[JFNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
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JVM-3 Mk\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LLUGlEPTB;MUm4MlQyQSEQvF2= MkDpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
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