CHIR-99021 (CT99021)

For research use only. Not for use in humans.

製品コードS1263

CHIR-99021 (CT99021)化学構造

CAS No. 252917-06-9

CHIR-99021 (CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs. CHIR99021 functions as a Wnt/β-catenin activator and induces autophagy.

サイズ 価格(税別)  
JPY 16900
JPY 30200
JPY 96600
JPY 163000
最寄りの販売代理店を探す

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バルク問合せ

文献中Selleckの製品使用例(519)

製品安全説明書

GSK-3阻害剤の選択性比較

生物活性

製品説明 CHIR-99021 (CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs. CHIR99021 functions as a Wnt/β-catenin activator and induces autophagy.
ターゲット
GSK-3β [1]
(Cell-free assay)
GSK-3α [1]
(Cell-free assay)
6.7 nM 10 nM
体外試験

CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. Furthermore, CHIR-99021 shows only weak binding to a panel of 22 pharmacologically relevant receptors and little inhibitory activity against a panel of 23 nonkinase enzymes. CHIR-99021 induces the activation of glycogen synthase (GS) in insulin receptor-expressing CHO-IR cells with EC50 of 0.763 μM[1].

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
LOUCY MmHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrJTWM2OD1zOEKuOlg5KM7:TR?= MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
SN12C MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTF6Mj64Nlkh|ryP MoHIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
A427 NGfFXoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3JTWM2OD1zOESuOlMyKM7:TR?= M4HsN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
DOK MojCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3q1VWlEPTB;MUi0MlY1OyEQvF2= Mn;IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
MDA-MB-415 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LzemlEPTB;MUi0MlY2OSEQvF2= NFnmVVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
MRK-nu-1 Mn7BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIT1RnNKSzVyPUG4OE46PzJizszN NWGxfY01RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
LB2241-RCC NHPp[IhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfRc5JKSzVyPUG4OU4yPDVizszN M3HMdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
NCI-H1563 NVTLcWg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTF6NT6yNFkh|ryP MnvxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
MDA-MB-453 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\WNWlEPTB;MUi2Mlk1OSEQvF2= MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
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CAPAN-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDJc2tEUUN3ME2xPFcvPDV|IN88US=> NUfIS2FORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
SK-LU-1 NITOW45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1juVGlEPTB;MUi4MlQzQCEQvF2= MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
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KG-1 MkPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDDZYJKSzVyPUG4PU44QThizszN MlrLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
ETK-1 NHK0c3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlyyTWM2OD1zOUCuNVgyKM7:TR?= NIrTVYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
NCI-H838 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LySWlEPTB;MUmwMlM1KM7:TR?= MmKyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
HCE-4 NG\2PYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MluwTWM2OD1zOUCuPVkzKM7:TR?= NX\H[|N4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
A2780 NUPVcJlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoWxTWM2OD1zOUKuPFkyKM7:TR?= M{XIO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
COLO-668 NIrVUmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjqTWM2OD1zOUOuNVU4KM7:TR?= M3qwdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
HGC-27 M{i4dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1y0eWlEPTB;MUm1MlU{QCEQvF2= NEPKRVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
SW1088 M2rlW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\TTI5KSzVyPUG5OU43PzdizszN MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
KOSC-2 NHrsdnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\1TWM2OD1zOUWuPFE5KM7:TR?= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
SW780 NFT5XlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTF7Nj63N|Qh|ryP MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
TE-1 M4PHU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoC3TWM2OD1zOU[uNlYh|ryP Ml;UQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
22RV1 NVqxWJlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHB[ZZKSzVyPUG5O{41OjRizszN NETw[Zo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
IA-LM NXP5V49LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\iPWlEPTB;MUm3MlgzOiEQvF2= MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
TE-5 MmDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTrTWM2OD1zOUiuNFM{KM7:TR?= MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
JVM-3 MkPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHkTWM2OD1zOUiuOFE6KM7:TR?= Mn3lQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
HT55 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXriUW1nUUN3ME2xPVkvOTl{IN88US=> MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
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MFM-223 NH2zS4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{O4TmlEPTB;MkCxMlU5PyEQvF2= M33QSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
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HPAF-II M3W3Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTJyOT62O|Eh|ryP MlP5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
NUGC-3 NXzoeVM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3LTWM2OD1{MEmuOlc5KM7:TR?= MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
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